JP2010539978A5 - - Google Patents

Info

Publication number

JP2010539978A5

JP2010539978A5 JP2010527987A JP2010527987A JP2010539978A5 JP 2010539978 A5 JP2010539978 A5 JP 2010539978A5 JP 2010527987 A JP2010527987 A JP 2010527987A JP 2010527987 A JP2010527987 A JP 2010527987A JP 2010539978 A5 JP2010539978 A5 JP 2010539978A5

Authority

JP

Japan

Prior art keywords

seq

mir

nucleic acid

acid unit

pharmaceutical composition

Prior art date

2008-10-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000007523 nucleic acids Chemical class 0.000 claims 18
• 108020004707 nucleic acids Proteins 0.000 claims 12
• 102000039446 nucleic acids Human genes 0.000 claims 12
• -1 2 (SEQ ID NO: 40) Proteins 0.000 claims 10
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 108091007773 MIR100 Proteins 0.000 claims 3
• 108091080995 Mir-9/mir-79 microRNA precursor family Proteins 0.000 claims 3
• 239000002253 acid Substances 0.000 claims 3
• 108091045440 let-7a-1 stem-loop Proteins 0.000 claims 3
• 108091050724 let-7b stem-loop Proteins 0.000 claims 3
• 108091030917 let-7b-1 stem-loop Proteins 0.000 claims 3
• 108091082924 let-7b-2 stem-loop Proteins 0.000 claims 3
• 108091050170 miR-103-1 stem-loop Proteins 0.000 claims 3
• 108091057431 miR-30d stem-loop Proteins 0.000 claims 3
• 108091090692 miR-337 stem-loop Proteins 0.000 claims 3
• 108091079013 miR-34b Proteins 0.000 claims 3
• 108091084018 miR-34b stem-loop Proteins 0.000 claims 3
• 108091063470 miR-34b-1 stem-loop Proteins 0.000 claims 3
• 108091049916 miR-34b-2 stem-loop Proteins 0.000 claims 3
• 108091057222 miR-34b-3 stem-loop Proteins 0.000 claims 3
• 108091092639 miR-34b-4 stem-loop Proteins 0.000 claims 3
• 108091042838 miR-524 stem-loop Proteins 0.000 claims 3
• 108091037014 miR-7-1 stem-loop Proteins 0.000 claims 3
• 108091047084 miR-9 stem-loop Proteins 0.000 claims 3
• 239000002243 precursor Substances 0.000 claims 3
• 229920002477 rna polymer Polymers 0.000 claims 3
• 108091007774 MIR107 Proteins 0.000 claims 2
• 108091028080 MiR-132 Proteins 0.000 claims 2
• 108091033433 MiR-191 Proteins 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 108091077112 miR-128a stem-loop Proteins 0.000 claims 2
• 108091079012 miR-133a Proteins 0.000 claims 2
• 108091024038 miR-133a stem-loop Proteins 0.000 claims 2
• 108091079658 miR-142-1 stem-loop Proteins 0.000 claims 2
• 108091071830 miR-142-2 stem-loop Proteins 0.000 claims 2
• 108091039097 miR-193b stem-loop Proteins 0.000 claims 2
• 108091046261 miR-198 stem-loop Proteins 0.000 claims 2
• 108091059105 miR-216-1 stem-loop Proteins 0.000 claims 2
• 108091045470 miR-216-2 stem-loop Proteins 0.000 claims 2
• 108091062761 miR-448 stem-loop Proteins 0.000 claims 2
• 108091069917 miR-491 stem-loop Proteins 0.000 claims 2
• 108091063340 miR-497 stem-loop Proteins 0.000 claims 2
• 108091049470 miR-498 stem-loop Proteins 0.000 claims 2
• 108091057331 miR-509 stem-loop Proteins 0.000 claims 2
• 108091077027 miR-518b stem-loop Proteins 0.000 claims 2
• 108091065658 miR-518b-1 stem-loop Proteins 0.000 claims 2
• 108091053758 miR-518b-2 stem-loop Proteins 0.000 claims 2
• 108091028859 miR-518b-3 stem-loop Proteins 0.000 claims 2
• 108091083761 miR-518b-4 stem-loop Proteins 0.000 claims 2
• 108091044445 miR-518f stem-loop Proteins 0.000 claims 2
• 108091036604 miR-518f-1 stem-loop Proteins 0.000 claims 2
• 108091080798 miR-518f-2 stem-loop Proteins 0.000 claims 2
• 108091052995 miR-520f stem-loop Proteins 0.000 claims 2
• 108091025782 miR-520g stem-loop Proteins 0.000 claims 2
• 108091051536 miR-523 stem-loop Proteins 0.000 claims 2
• 108091043186 miR-526a stem-loop Proteins 0.000 claims 2
• 102000003951 Erythropoietin Human genes 0.000 claims 1
• 108090000394 Erythropoietin Proteins 0.000 claims 1
• 208000031220 Hemophilia Diseases 0.000 claims 1
• 208000009292 Hemophilia A Diseases 0.000 claims 1
• 108091093037 Peptide nucleic acid Proteins 0.000 claims 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 1
• 125000005600 alkyl phosphonate group Chemical group 0.000 claims 1
• 150000001412 amines Chemical class 0.000 claims 1
• 208000007502 anemia Diseases 0.000 claims 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 1
• 229940105423 erythropoietin Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 108091050539 miR-107 stem-loop Proteins 0.000 claims 1
• 108091059056 miR-452 stem-loop Proteins 0.000 claims 1
• 108091024613 miR-520b stem-loop Proteins 0.000 claims 1
• 108091027598 miR-525 stem-loop Proteins 0.000 claims 1
• 108091032786 miR-552 stem-loop Proteins 0.000 claims 1
• 108091007422 miR-98 Proteins 0.000 claims 1
• 108091070501 miRNA Proteins 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 1
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
• 208000007056 sickle cell anemia Diseases 0.000 claims 1