JP2010512747A5 - - Google Patents

Info

Publication number

JP2010512747A5

JP2010512747A5 JP2009541384A JP2009541384A JP2010512747A5 JP 2010512747 A5 JP2010512747 A5 JP 2010512747A5 JP 2009541384 A JP2009541384 A JP 2009541384A JP 2009541384 A JP2009541384 A JP 2009541384A JP 2010512747 A5 JP2010512747 A5 JP 2010512747A5

Authority

JP

Japan

Prior art keywords

nucleic acid

acid molecule

isolated nucleic

seq

molecule according

Prior art date

2007-12-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000007523 nucleic acids Chemical class 0.000 claims 32
• 108020004707 nucleic acids Proteins 0.000 claims 29
• 102000039446 nucleic acids Human genes 0.000 claims 29
• 239000000203 mixture Substances 0.000 claims 5
• 239000002773 nucleotide Substances 0.000 claims 5
• 125000003729 nucleotide group Chemical group 0.000 claims 5
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
• 208000024172 Cardiovascular disease Diseases 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 208000021642 Muscular disease Diseases 0.000 claims 2
• 238000007385 chemical modification Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 235000000346 sugar Nutrition 0.000 claims 2
• 150000008163 sugars Chemical group 0.000 claims 2
• 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
• 108091027075 5S-rRNA precursor Proteins 0.000 claims 1
• 239000012445 acidic reagent Substances 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
• 238000012986 modification Methods 0.000 claims 1
• 229940046166 oligodeoxynucleotide Drugs 0.000 claims 1
• 230000004962 physiological condition Effects 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 238000011282 treatment Methods 0.000 claims 1
• 238000011269 treatment regimen Methods 0.000 claims 1