JP2010512747A - 筋疾患および心臓血管障害を処置するための組成物および方法 - Google Patents

筋疾患および心臓血管障害を処置するための組成物および方法 Download PDF

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JP2010512747A
JP2010512747A JP2009541384A JP2009541384A JP2010512747A JP 2010512747 A JP2010512747 A JP 2010512747A JP 2009541384 A JP2009541384 A JP 2009541384A JP 2009541384 A JP2009541384 A JP 2009541384A JP 2010512747 A JP2010512747 A JP 2010512747A
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nucleic acid
mir
seq
acid molecule
isolated nucleic
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JP2010512747A5 (enExample
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イワン・ブーフィンク
ジョナサン・ホール
ヤン・ヴァイラー
クリスチャン・シュネル
マティアス・ミューラー
マルティナ・シンケ−ブラウン
ファブリツィオ・セルルカ
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ノバルティス アーゲー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs

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  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2009541384A 2006-12-14 2007-12-13 筋疾患および心臓血管障害を処置するための組成物および方法 Withdrawn JP2010512747A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86993706P 2006-12-14 2006-12-14
PCT/US2007/025535 WO2008076324A2 (en) 2006-12-14 2007-12-13 Compositions and methods to treat muscular & cardiovascular disorders

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011178297A Division JP2012019789A (ja) 2006-12-14 2011-08-17 筋疾患および心臓血管障害を処置するための組成物および方法
JP2012034691A Division JP2012131812A (ja) 2006-12-14 2012-02-21 筋疾患および心臓血管障害を処置するための組成物および方法

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JP2010512747A5 JP2010512747A5 (enExample) 2011-02-03

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JP2009541384A Withdrawn JP2010512747A (ja) 2006-12-14 2007-12-13 筋疾患および心臓血管障害を処置するための組成物および方法
JP2011178297A Withdrawn JP2012019789A (ja) 2006-12-14 2011-08-17 筋疾患および心臓血管障害を処置するための組成物および方法
JP2012034691A Withdrawn JP2012131812A (ja) 2006-12-14 2012-02-21 筋疾患および心臓血管障害を処置するための組成物および方法

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JP2011178297A Withdrawn JP2012019789A (ja) 2006-12-14 2011-08-17 筋疾患および心臓血管障害を処置するための組成物および方法
JP2012034691A Withdrawn JP2012131812A (ja) 2006-12-14 2012-02-21 筋疾患および心臓血管障害を処置するための組成物および方法

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US (3) US20100280094A1 (enExample)
EP (1) EP2104733A2 (enExample)
JP (3) JP2010512747A (enExample)
KR (1) KR20090098818A (enExample)
CN (2) CN101563458A (enExample)
AU (1) AU2007334502B2 (enExample)
BR (1) BRPI0719995A2 (enExample)
CA (1) CA2672606A1 (enExample)
EA (2) EA200900782A1 (enExample)
MX (1) MX2009006310A (enExample)
WO (1) WO2008076324A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516856A (ja) * 2009-02-04 2012-07-26 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 心臓障害の治療におけるmir−208およびmir−499の二重ターゲティング
JP2015536132A (ja) * 2012-10-15 2015-12-21 アイシス ファーマシューティカルズ, インコーポレーテッド C9orf72発現を調節するための組成物

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JP5718570B2 (ja) 2006-08-01 2015-05-13 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム ベータミオシン重鎖の発現を活性化するマイクロrnaの同定
AU2008283794B2 (en) 2007-07-31 2014-03-20 Board Of Regents, The University Of Texas System Micro-RNAs that control myosin expression and myofiber identity
IE20090047A1 (en) * 2009-02-26 2010-09-29 Nat Univ Ireland Protein targets in disease
CA2755207A1 (en) * 2009-03-12 2010-09-16 Brandeis University Reagents and methods for pcr
MX2013005875A (es) 2010-12-15 2014-04-30 Miragen Therapeutics Inhibidores de microarn que comprenden nucleotidos bloqueados.
AU2013201303C1 (en) 2011-10-06 2016-06-23 MiRagen Therapeutics, Inc. Control of whole body energy homeostasis by microRNA regulation
KR101928418B1 (ko) 2012-06-21 2018-12-12 미라젠 세러퓨틱스 인코포레이티드 잠금 핵산 모티프를 포함하는 올리고뉴클레오티드-기반 억제제
WO2014062736A1 (en) 2012-10-15 2014-04-24 Isis Pharmaceuticals, Inc. Methods for monitoring c9orf72 expression
WO2014169126A1 (en) * 2013-04-10 2014-10-16 Reveragen Biopharma, Inc. Methods and agents to increase therapeutic dystrophin expression in muscle
SG11201602597YA (en) 2013-10-11 2016-05-30 Ionis Pharmaceuticals Inc Compositions for modulating c9orf72 expression
JP6637961B2 (ja) * 2014-08-04 2020-01-29 ミラゲン セラピューティクス, インコーポレイテッド Myh7bの阻害剤およびその使用
MX2017009427A (es) 2015-01-20 2017-10-02 Miragen Therapeutics Inc Inhibidores de mir-92 y usos de los mismos.
SG11201708468YA (en) 2015-04-16 2017-11-29 Ionis Pharmaceuticals Inc Compositions for modulating c9orf72 expression
WO2017079291A1 (en) 2015-11-02 2017-05-11 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating c90rf72
CN106148519A (zh) * 2016-07-05 2016-11-23 无锡市第二人民医院 一种microRNA‑499的快速检测方法
US12054711B2 (en) 2017-07-14 2024-08-06 City Of Hope Meta-stable oligonucleotides junctions for delivery of therapeutics
WO2019033079A1 (en) * 2017-08-10 2019-02-14 City Of Hope CONDITIONAL RNAIDS AND THEIR USES IN THE TREATMENT OF CARDIAC HYPERTROPHY
KR102281710B1 (ko) 2021-02-19 2021-07-28 조기정 에어튜브를 이용한 선박 안전장치
CN119246849B (zh) * 2024-12-09 2025-03-14 上海基灵生物科技有限公司 一种检测犬心脏损伤的试剂盒及应用

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US5489677A (en) * 1990-07-27 1996-02-06 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
IL99066A (en) * 1990-08-03 1996-01-31 Sterling Winthrop Inc Nuclease resistant compounds comprising an oligonucleotide sequence having a diol at either or both termini and compositions containing them
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
JP3516167B2 (ja) * 1992-12-08 2004-04-05 ローム株式会社 タンタルコンデンサチップの製造方法
US6271359B1 (en) * 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
CZ302719B6 (cs) * 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
EP2567693B1 (en) * 2003-07-16 2015-10-21 Protiva Biotherapeutics Inc. Lipid encapsulated interfering RNA
WO2005021800A2 (en) * 2003-08-22 2005-03-10 Sirna Therapeutics, Inc. Detection and quantitation of nucleic acid molecules in biological samples
EP2322650A1 (en) * 2004-05-14 2011-05-18 Rosetta Genomics Ltd MicroRNAs and uses thereof
WO2006107826A2 (en) * 2005-04-04 2006-10-12 The Board Of Regents Of The University Of Texas System Micro-rna's that regulate muscle cells
US20070092882A1 (en) * 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
ES2612903T3 (es) * 2006-01-10 2017-05-19 Koninklijke Nederlandse Akademie Van Wetenschappen Moléculas de ácido nucleico y colecciones de las mismas, su aplicación e identificación
JP5718570B2 (ja) * 2006-08-01 2015-05-13 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム ベータミオシン重鎖の発現を活性化するマイクロrnaの同定
AU2008283794B2 (en) * 2007-07-31 2014-03-20 Board Of Regents, The University Of Texas System Micro-RNAs that control myosin expression and myofiber identity

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516856A (ja) * 2009-02-04 2012-07-26 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 心臓障害の治療におけるmir−208およびmir−499の二重ターゲティング
JP2015536132A (ja) * 2012-10-15 2015-12-21 アイシス ファーマシューティカルズ, インコーポレーテッド C9orf72発現を調節するための組成物
JP2019141075A (ja) * 2012-10-15 2019-08-29 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. C9orf72発現を調節するための組成物
JP2021176329A (ja) * 2012-10-15 2021-11-11 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals, Inc. C9orf72発現を調節するための組成物

Also Published As

Publication number Publication date
US20100280094A1 (en) 2010-11-04
US20120041052A1 (en) 2012-02-16
JP2012131812A (ja) 2012-07-12
AU2007334502A1 (en) 2008-06-26
CN102604951A (zh) 2012-07-25
CN101563458A (zh) 2009-10-21
EA201101361A1 (ru) 2012-11-30
US20120114744A1 (en) 2012-05-10
WO2008076324A2 (en) 2008-06-26
EA200900782A1 (ru) 2009-12-30
MX2009006310A (es) 2009-07-22
JP2012019789A (ja) 2012-02-02
KR20090098818A (ko) 2009-09-17
CA2672606A1 (en) 2008-06-26
EP2104733A2 (en) 2009-09-30
BRPI0719995A2 (pt) 2014-03-18
WO2008076324A3 (en) 2009-04-09
AU2007334502B2 (en) 2011-12-15

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