|
WO2011140441A2
(en)
|
2010-05-06 |
2011-11-10 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US10039777B2
(en)
|
2012-03-20 |
2018-08-07 |
Neuro-Lm Sas |
Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
|
|
EP4570908A3
(en)
|
2012-05-25 |
2025-10-22 |
The Regents of the University of California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
CN116064532A
(zh)
|
2012-10-23 |
2023-05-05 |
基因工具股份有限公司 |
用于切割靶dna的组合物及其用途
|
|
SG11201503824SA
(en)
|
2012-12-06 |
2015-06-29 |
Sigma Aldrich Co Llc |
Crispr-based genome modification and regulation
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
EP2931892B1
(en)
|
2012-12-12 |
2018-09-12 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
WO2014093622A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
WO2014093595A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
|
SMT202100516T1
(it)
|
2013-04-16 |
2021-11-12 |
Regeneron Pharma |
Modificazione mirata del genoma di ratto
|
|
WO2014204725A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
WO2014204729A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
AU2014281026B2
(en)
|
2013-06-17 |
2020-05-28 |
Massachusetts Institute Of Technology |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
RU2716420C2
(ru)
|
2013-06-17 |
2020-03-11 |
Те Брод Инститьют Инк. |
Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
TW201542816A
(zh)
|
2013-09-18 |
2015-11-16 |
Kymab Ltd |
方法、細胞與生物體
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
ES2670983T3
(es)
|
2013-11-07 |
2018-06-04 |
Editas Medicine, Inc. |
Métodos y composiciones relacionados con CRISPR con ARNg rectores
|
|
BR112016013400B1
(pt)
|
2013-12-11 |
2023-02-14 |
Regeneron Pharmaceuticals, Inc. |
Método in vitro para modificar um genoma em um lócus genômico de interesse em uma célula pluripotente
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
CA2932439A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
WO2015089465A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders
|
|
CA2932478A1
(en)
*
|
2013-12-12 |
2015-06-18 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
US11053481B2
(en)
|
2013-12-12 |
2021-07-06 |
President And Fellows Of Harvard College |
Fusions of Cas9 domains and nucleic acid-editing domains
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
AU2015222944A1
(en)
|
2014-02-27 |
2016-09-08 |
Massachusetts Institute Of Technology |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
EP3149156B1
(en)
|
2014-05-28 |
2021-02-17 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into gastric tissues through directed differentiation
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
EP3686279B1
(en)
|
2014-08-17 |
2023-01-04 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
CN107002042A
(zh)
|
2014-10-15 |
2017-08-01 |
瑞泽恩制药公司 |
用于产生或维持多能细胞的方法和组合物
|
|
EP3212788A2
(en)
|
2014-10-27 |
2017-09-06 |
The Broad Institute, Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
CA2963820A1
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
MX389266B
(es)
|
2014-11-21 |
2025-03-20 |
Regeneron Pharma |
Metodos y composiciones para la modificacion genetica dirigida mediante el uso de arn guia combinados.
|
|
WO2016086197A1
(en)
|
2014-11-25 |
2016-06-02 |
The Brigham And Women's Hospital, Inc. |
Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
JP6830437B2
(ja)
|
2014-12-10 |
2021-02-17 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
疾患を処置するための遺伝子改変された細胞、組織および臓器
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3230451B1
(en)
|
2014-12-12 |
2021-04-07 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016100974A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
EP3702456A1
(en)
|
2014-12-24 |
2020-09-02 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
CN104611368B
(zh)
*
|
2015-01-15 |
2018-05-25 |
中国科学院广州生物医药与健康研究院 |
重组后不产生移码突变的载体、在爪蛙基因组中进行基因定点敲入的方法及应用
|
|
EP3262193A2
(en)
|
2015-02-26 |
2018-01-03 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
US10900036B2
(en)
*
|
2015-03-17 |
2021-01-26 |
The General Hospital Corporation |
RNA interactome of polycomb repressive complex 1 (PRC1)
|
|
GB2536650A
(en)
|
2015-03-24 |
2016-09-28 |
Augmedics Ltd |
Method and system for combining video-based and optic-based augmented reality in a near eye display
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
EP3288594B1
(en)
*
|
2015-04-27 |
2022-06-29 |
The Trustees of The University of Pennsylvania |
Dual aav vector system for crispr/cas9 mediated correction of human disease
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
US11390884B2
(en)
|
2015-05-11 |
2022-07-19 |
Editas Medicine, Inc. |
Optimized CRISPR/cas9 systems and methods for gene editing in stem cells
|
|
CA2986021A1
(en)
*
|
2015-05-16 |
2016-11-24 |
Genzyme Corporation |
Gene editing of deep intronic mutations
|
|
CA2987927C
(en)
|
2015-06-01 |
2024-03-19 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions for rna-guided treatment of hiv infection
|
|
CN116334142A
(zh)
|
2015-06-09 |
2023-06-27 |
爱迪塔斯医药公司 |
用于改善移植的crispr/cas相关方法和组合物
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
CA2989830A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute, Inc. |
Crispr enzyme mutations reducing off-target effects
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
CA3012607A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Crispr enzymes and systems
|
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
EP3430134B1
(en)
|
2015-06-18 |
2022-09-21 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
AU2016285724A1
(en)
|
2015-06-29 |
2017-11-16 |
Ionis Pharmaceuticals, Inc. |
Modified CRISPR RNA and modified single CRISPR RNA and uses thereof
|
|
IL257105B
(en)
|
2015-07-31 |
2022-09-01 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
CA2994969A1
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
|
|
EP4512819A3
(en)
|
2015-08-12 |
2025-08-06 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
|
WO2017031370A1
(en)
|
2015-08-18 |
2017-02-23 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
US20180346531A1
(en)
*
|
2015-09-15 |
2018-12-06 |
Regents Of The University Of California |
Compositions and methods for delivering biotherapeutics
|
|
WO2017053879A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
WO2017070605A1
(en)
|
2015-10-22 |
2017-04-27 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
|
IL294014B2
(en)
|
2015-10-23 |
2024-07-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
US11492670B2
(en)
|
2015-10-27 |
2022-11-08 |
The Broad Institute Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
WO2017075265A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute, Inc. |
Multiplex analysis of single cell constituents
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017087708A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
|
MX2018008106A
(es)
|
2015-12-30 |
2019-03-14 |
Novartis Ag |
Terapias con celulas inmunoefectoras de una eficacia mejorada.
|
|
BR112018013679A2
(pt)
|
2016-01-11 |
2019-01-22 |
Univ Leland Stanford Junior |
proteínas quiméricas e métodos de regulação de expressão gênica
|
|
JP7012645B2
(ja)
|
2016-01-11 |
2022-01-28 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
キメラタンパク質および免疫治療の方法
|
|
RU2749050C2
(ru)
|
2016-01-27 |
2021-06-03 |
Онкорус, Инк. |
Онколитические вирусные векторы и их применение
|
|
EP3413925A1
(en)
*
|
2016-02-12 |
2018-12-19 |
Combigene AB |
Vector
|
|
US20190144942A1
(en)
|
2016-02-22 |
2019-05-16 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating immune phenotypes
|
|
US11427861B2
(en)
|
2016-03-17 |
2022-08-30 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
|
WO2017201476A1
(en)
|
2016-05-20 |
2017-11-23 |
Regeneron Pharmaceuticals, Inc. |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
BR112018076190A2
(pt)
|
2016-06-17 |
2019-06-18 |
Massachusetts Inst Technology |
ortólogos e sistemas crispr tipo vi
|
|
EP4282478A3
(en)
|
2016-06-21 |
2024-03-06 |
The Curators of the University of Missouri |
Modified dystrophin proteins
|
|
US20200069818A1
(en)
*
|
2016-07-05 |
2020-03-05 |
The Johns Hopkins University |
Crispr/cas9-based compositions and methods for treating cancer
|
|
JP7033583B2
(ja)
|
2016-07-13 |
2022-03-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ゲノム編集効率を高めるための方法、組成物及びキット
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
CN109804066A
(zh)
|
2016-08-09 |
2019-05-24 |
哈佛大学的校长及成员们 |
可编程cas9-重组酶融合蛋白及其用途
|
|
WO2018035364A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
EP3500671B1
(en)
*
|
2016-08-17 |
2024-07-10 |
The Broad Institute, Inc. |
Method of selecting target sequences for the design of guide rnas
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
EP3500670B1
(en)
|
2016-08-17 |
2024-07-10 |
The Broad Institute, Inc. |
Method for selecting target sequences for guide rna of crispr systems
|
|
SG11201901306XA
(en)
*
|
2016-08-19 |
2019-03-28 |
Toolgen Inc |
Artificially engineered angiogenesis regulatory system
|
|
CA3034369A1
(en)
*
|
2016-08-19 |
2018-02-22 |
Whitehead Institute For Biomedical Research |
Methods of editing dna methylation
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
WO2018053053A1
(en)
|
2016-09-13 |
2018-03-22 |
The Broad Institute, Inc. |
Proximity-dependent biotinylation and uses thereof
|
|
US12499971B2
(en)
|
2016-09-28 |
2025-12-16 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
CN110214180A
(zh)
|
2016-10-14 |
2019-09-06 |
哈佛大学的校长及成员们 |
核碱基编辑器的aav递送
|
|
CN110520530A
(zh)
|
2016-10-18 |
2019-11-29 |
明尼苏达大学董事会 |
肿瘤浸润性淋巴细胞和治疗方法
|
|
EP3535396A1
(en)
|
2016-11-01 |
2019-09-11 |
Novartis AG |
Methods and compositions for enhancing gene editing
|
|
SG11201903697WA
(en)
|
2016-11-04 |
2019-05-30 |
Childrens Hospital Med Ct |
Liver organoid compositions and methods of making and using same
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
WO2018107103A1
(en)
|
2016-12-09 |
2018-06-14 |
The Broad Institute, Inc. |
Crispr-systems for modifying a trait of interest in a plant
|
|
EP3555297A1
(en)
|
2016-12-19 |
2019-10-23 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
WO2018129203A2
(en)
*
|
2017-01-06 |
2018-07-12 |
The Regents Of The University Of California |
Method for temporal and tissue-specific drug delivery and induced nucleic acid recombination
|
|
WO2018129368A2
(en)
|
2017-01-06 |
2018-07-12 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
WO2018131551A1
(ja)
*
|
2017-01-13 |
2018-07-19 |
学校法人自治医科大学 |
肝臓ゲノム上の凝固関連因子遺伝子を破壊するためのａａｖベクター
|
|
WO2018140644A1
(en)
*
|
2017-01-25 |
2018-08-02 |
Musc Foundation For Research Development |
Modified t cells and uses thereof
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
EP3579858A4
(en)
*
|
2017-02-07 |
2020-12-23 |
The Regents of The University of California |
GENE THERAPY AGAINST HAPLOINSUFFICIENCY
|
|
WO2018148440A1
(en)
|
2017-02-08 |
2018-08-16 |
Dana-Farber Cancer Institute, Inc. |
Regulating chimeric antigen receptors
|
|
AU2018224387B2
(en)
*
|
2017-02-22 |
2024-08-08 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
GB2574769A
(en)
*
|
2017-03-03 |
2019-12-18 |
Univ California |
RNA Targeting of mutations via suppressor tRNAs and deaminases
|
|
WO2018165631A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
US11332727B2
(en)
*
|
2017-03-14 |
2022-05-17 |
The Regents Of The University Of California |
Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector
|
|
EP3596207B1
(en)
|
2017-03-15 |
2023-12-20 |
The Broad Institute, Inc. |
Novel cas13b orthologues crispr enzymes and systems
|
|
EP3596218B1
(en)
|
2017-03-15 |
2023-08-23 |
The Broad Institute, Inc. |
Crispr effector system based diagnostics for virus detection
|
|
US12180546B2
(en)
|
2017-03-17 |
2024-12-31 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
JP2020511521A
(ja)
*
|
2017-03-23 |
2020-04-16 |
ディーエヌエーアールエックス |
ｉｎ ｖｉｖｏでの核酸発現のためのシステム及び方法
|
|
US12161694B2
(en)
|
2017-03-24 |
2024-12-10 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
WO2018183921A1
(en)
|
2017-04-01 |
2018-10-04 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
WO2018191520A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
EP3610009A1
(en)
|
2017-04-12 |
2020-02-19 |
The Broad Institute, Inc. |
Novel type vi crispr orthologs and systems
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
WO2018191673A1
(en)
|
2017-04-14 |
2018-10-18 |
Children's Hospital Medical Center |
Multi donor stem cell compositions and methods of making same
|
|
US12350368B2
(en)
|
2017-04-14 |
2025-07-08 |
The Broad Institute, Inc. |
Delivery of large payloads
|
|
EP3612629A1
(en)
|
2017-04-18 |
2020-02-26 |
The Broad Institute, Inc. |
Compositions for detecting secretion and methods of use
|
|
US12208140B2
(en)
|
2017-04-21 |
2025-01-28 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
WO2018201086A1
(en)
|
2017-04-28 |
2018-11-01 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
|
WO2018204777A2
(en)
|
2017-05-05 |
2018-11-08 |
The Broad Institute, Inc. |
Methods for identification and modification of lncrna associated with target genotypes and phenotypes
|
|
WO2018209324A2
(en)
|
2017-05-11 |
2018-11-15 |
The Broad Institute, Inc. |
Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
US20200172927A1
(en)
*
|
2017-05-15 |
2020-06-04 |
The Trustees Of Columbia University In The City Of New York |
Reprogramming metabolism by inhibiting vhl for treatment of neurodegeneration
|
|
KR102678809B1
(ko)
|
2017-05-18 |
2024-06-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 시스템, 방법 및 조성물
|
|
US12297436B2
(en)
|
2017-05-18 |
2025-05-13 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
EP3406139A1
(en)
*
|
2017-05-26 |
2018-11-28 |
Medizinische Hochschule Hannover |
Method for genetically modifying a vascularised tissue
|
|
EP3635113A4
(en)
|
2017-06-05 |
2021-03-17 |
Fred Hutchinson Cancer Research Center |
SAFE GENOMIC HAVERS FOR GENETIC THERAPIES IN HUMAN STEM CELLS AND NANOPARTICLES MODIFIED TO ENABLE TARGETED GENETIC THERAPIES
|
|
KR102746733B1
(ko)
|
2017-06-09 |
2024-12-24 |
에디타스 메디신, 인코포레이티드 |
조작된 cas9 뉴클레아제
|
|
EP3638218A4
(en)
|
2017-06-14 |
2021-06-09 |
The Broad Institute, Inc. |
COMPOSITIONS AND METHOD OF TARGETING COMPLEMENTING COMPONENT 3 FOR INHIBITION OF TUMOR GROWTH
|
|
WO2018232382A1
(en)
*
|
2017-06-16 |
2018-12-20 |
Applied Stemcell, Inc. |
Gene editing methods with increased knock-in efficiency
|
|
WO2019005884A1
(en)
|
2017-06-26 |
2019-01-03 |
The Broad Institute, Inc. |
CRISPR / CAS-ADENINE DEAMINASE COMPOSITIONS, SYSTEMS AND METHODS FOR TARGETED NUCLEIC ACID EDITION
|
|
KR102007457B1
(ko)
*
|
2017-06-30 |
2019-08-05 |
동국대학교 산학협력단 |
Cas9 단백질, 가이드 RNA 및 양친매성 펩타이드를 포함하는 나노복합체 및 이의 용도
|
|
JP2020530307A
(ja)
|
2017-06-30 |
2020-10-22 |
インティマ・バイオサイエンス，インコーポレーテッド |
遺伝子治療のためのアデノ随伴ウイルスベクター
|
|
AU2018292181B2
(en)
|
2017-06-30 |
2025-04-10 |
Cellectis |
Cellular immunotherapy for repetitive administration
|
|
US20200140896A1
(en)
|
2017-06-30 |
2020-05-07 |
Novartis Ag |
Methods for the treatment of disease with gene editing systems
|
|
WO2019014581A1
(en)
|
2017-07-14 |
2019-01-17 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE
|
|
WO2019014564A1
(en)
|
2017-07-14 |
2019-01-17 |
Editas Medicine, Inc. |
SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
|
|
WO2019018440A1
(en)
|
2017-07-17 |
2019-01-24 |
The Broad Institute, Inc. |
HUMAN COLON CELL ATLAS IN GOOD HEALTH AND WITH HEMORRHAGIC RECTO-COLITIS
|
|
US12239646B2
(en)
|
2017-07-19 |
2025-03-04 |
Dana-Farber Cancer Institute, Inc. |
Cancer diagnostic and treatment
|
|
CN109295054B
(zh)
*
|
2017-07-25 |
2024-02-06 |
广州普世利华科技有限公司 |
用于靶向病原体基因RNA的gRNA及基于C2c2的病原体基因的检测方法及试剂盒
|
|
BR112020001559A2
(pt)
|
2017-07-26 |
2020-08-11 |
Oncorus, Inc. |
vetores virais oncolíticos e usos dos mesmos
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
|
WO2019060746A1
(en)
|
2017-09-21 |
2019-03-28 |
The Broad Institute, Inc. |
SYSTEMS, METHODS, AND COMPOSITIONS FOR THE TARGETED EDITING OF NUCLEIC ACIDS
|
|
WO2019067875A1
(en)
|
2017-09-29 |
2019-04-04 |
Regeneron Pharmaceuticals, Inc. |
NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE
|
|
EP3695408B1
(en)
|
2017-10-02 |
2026-01-21 |
The Broad Institute, Inc. |
Medical use of cdk4/6- and checkpoint-inhibitors in phased combination, in treatment of cancer
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
WO2019074793A1
(en)
|
2017-10-10 |
2019-04-18 |
Children's Hospital Medical Center |
OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME
|
|
CN109646678A
(zh)
*
|
2017-10-12 |
2019-04-19 |
中国科学院上海生命科学研究院 |
Sun2蛋白、其制药用途及药物
|
|
US11680296B2
(en)
|
2017-10-16 |
2023-06-20 |
Massachusetts Institute Of Technology |
Mycobacterium tuberculosis host-pathogen interaction
|
|
CN111757937A
(zh)
|
2017-10-16 |
2020-10-09 |
布罗德研究所股份有限公司 |
腺苷碱基编辑器的用途
|
|
BR112020007823A2
(pt)
|
2017-10-20 |
2020-10-27 |
Fred Hutchinson Cancer Research Center |
sistemas e métodos para produzir células b geneticamente modificadas para expressar anticorpos selecionados
|
|
WO2019135816A2
(en)
|
2017-10-23 |
2019-07-11 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US11547614B2
(en)
|
2017-10-31 |
2023-01-10 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
CN109536494A
(zh)
*
|
2017-10-31 |
2019-03-29 |
广东赤萌医疗科技有限公司 |
一种用于修复HBB1基因点突变的gRNA、基因编辑系统、表达载体和基因编辑试剂盒
|
|
WO2019087113A1
(en)
|
2017-11-01 |
2019-05-09 |
Novartis Ag |
Synthetic rnas and methods of use
|
|
US12171783B2
(en)
|
2017-11-13 |
2024-12-24 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas
|
|
US12221720B2
(en)
|
2017-11-13 |
2025-02-11 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
JP7522656B2
(ja)
|
2017-11-21 |
2024-07-25 |
クリスパー セラピューティクス アーゲー |
常染色体優性網膜色素変性の処置のための材料および方法
|
|
US12521201B2
(en)
|
2017-12-07 |
2026-01-13 |
Augmedics Ltd. |
Spinous process clamp
|
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
US12458411B2
(en)
|
2017-12-07 |
2025-11-04 |
Augmedics Ltd. |
Spinous process clamp
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
US12379372B2
(en)
|
2017-12-21 |
2025-08-05 |
Children's Hospital Medical Center |
Digitalized human organoids and methods of using same
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
IL276081B2
(en)
|
2018-01-17 |
2023-10-01 |
Vertex Pharma |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
|
CN111757876B
(zh)
|
2018-01-17 |
2024-03-22 |
沃泰克斯药物股份有限公司 |
Dna-pk抑制剂
|
|
KR20200109358A
(ko)
|
2018-01-17 |
2020-09-22 |
버텍스 파마슈티칼스 인코포레이티드 |
Dna-pk 억제제
|
|
US11173216B2
(en)
*
|
2018-01-18 |
2021-11-16 |
Wisconsin Alumni Research Foundation |
Gene editing-based method of attenuating the beta-amyloid pathway
|
|
EP3765094A4
(en)
|
2018-03-15 |
2021-12-22 |
KSQ Therapeutics, Inc. |
GENE REGULATORY COMPOSITIONS AND PROCEDURES FOR IMPROVED IMMUNOTHERAPY
|
|
EP3781711B1
(en)
|
2018-04-19 |
2024-11-20 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
|
JP2021523696A
(ja)
*
|
2018-04-23 |
2021-09-09 |
デューク ユニバーシティ |
Ｄｎａメチル化の標的化された編集によるｓｎｃａ発現の下方調節
|
|
SI3560330T1
(sl)
|
2018-04-24 |
2022-08-31 |
KWS SAAT SE & Co. KGaA |
Rastline z izboljšano prebavljivostjo in markerskimi haplotipi
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
EP3787543A4
(en)
|
2018-05-02 |
2022-01-19 |
Augmedics Ltd. |
REGISTRATION OF A FIDUCIAL MARKER FOR AN AUGMENTED REALITY SYSTEM
|
|
US20210386829A1
(en)
|
2018-05-04 |
2021-12-16 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
GB2589246A
(en)
|
2018-05-16 |
2021-05-26 |
Synthego Corp |
Methods and systems for guide RNA design and use
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
US20210147915A1
(en)
|
2018-06-26 |
2021-05-20 |
The Broad Institute, Inc. |
Crispr/cas and transposase based amplification compositions, systems and methods
|
|
MX2020013836A
(es)
|
2018-06-26 |
2021-05-27 |
Massachusetts Inst Technology |
Métodos, sistemas y diagnósticos de amplificación basados en el sistema efector crispr.
|
|
US12338436B2
(en)
|
2018-06-29 |
2025-06-24 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
IL260445B
(en)
*
|
2018-07-05 |
2019-08-29 |
Lempo Therapeutics Ltd |
Methods and compositions for modulating myeloperoxidase (mpo) expression
|
|
US20210214699A1
(en)
*
|
2018-07-05 |
2021-07-15 |
Lempo Therapeutics Ltd |
Methods and compositions for modulating myeloperoxidase (mpo) expression
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
CN112533619A
(zh)
|
2018-07-26 |
2021-03-19 |
儿童医院医学中心 |
肝-胆-胰组织和其制备方法
|
|
EP3830256A2
(en)
|
2018-07-31 |
2021-06-09 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2020033601A1
(en)
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Novel cas12b enzymes and systems
|
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
|
WO2020051507A1
(en)
|
2018-09-06 |
2020-03-12 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
US10724052B2
(en)
|
2018-09-07 |
2020-07-28 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
KR20210057781A
(ko)
|
2018-09-12 |
2021-05-21 |
칠드런즈 호스피탈 메디칼 센터 |
조혈 줄기세포 및 이의 파생체의 생산을 위한 오르가노이드 조성물
|
|
EP3849565A4
(en)
|
2018-09-12 |
2022-12-28 |
Fred Hutchinson Cancer Research Center |
REDUCTION OF CD33 EXPRESSION TO SELECTIVELY PROTECT THERAPEUTIC CELLS
|
|
JP7344300B2
(ja)
|
2018-09-18 |
2023-09-13 |
ブイエヌブイ ニューコ インク． |
Ａｒｃベースのカプシドおよびその使用
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
WO2020077236A1
(en)
|
2018-10-12 |
2020-04-16 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
WO2020103013A1
(en)
*
|
2018-11-21 |
2020-05-28 |
Nanjing Bioheng Biotech Co., Ltd |
Modified t cells and uses thereof
|
|
US11766296B2
(en)
|
2018-11-26 |
2023-09-26 |
Augmedics Ltd. |
Tracking system for image-guided surgery
|
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
WO2020131862A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
|
CN113518825A
(zh)
*
|
2018-12-23 |
2021-10-19 |
美国杰特贝林生物制品有限公司 |
Wiskott-aldrich综合征的造血干细胞基因疗法
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020191102A1
(en)
|
2019-03-18 |
2020-09-24 |
The Broad Institute, Inc. |
Type vii crispr proteins and systems
|
|
CA3130488A1
(en)
|
2019-03-19 |
2020-09-24 |
David R. Liu |
Methods and compositions for editing nucleotide sequences
|
|
EP3941523A4
(en)
*
|
2019-03-22 |
2022-12-28 |
Mayo Foundation for Medical Education and Research |
MATERIALS AND METHODS FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE
|
|
US20220162649A1
(en)
|
2019-04-01 |
2022-05-26 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US20220243287A1
(en)
|
2019-05-13 |
2022-08-04 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
|
US20220220469A1
(en)
|
2019-05-20 |
2022-07-14 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
WO2020236936A1
(en)
*
|
2019-05-21 |
2020-11-26 |
Beam Therapeutics Inc. |
Methods of editing a single nucleotide polymorphism using programmable base editor systems
|
|
JP7624410B2
(ja)
*
|
2019-05-21 |
2025-01-30 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
レット症候群の治療におけるコレステロール ２４－ヒドロラーゼのための発現ベクター
|
|
JP7616668B2
(ja)
*
|
2019-05-22 |
2025-01-17 |
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
Ｕｂｅ３ａ遺伝子および発現カセットならびにそれらの使用
|
|
KR20220012266A
(ko)
*
|
2019-05-23 |
2022-02-03 |
스페이스크래프트 세븐, 엘엘씨 |
영아 악성 골화석증을 위한 유전자 요법 벡터
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
CN114269361A
(zh)
|
2019-05-31 |
2022-04-01 |
儿童医院医学中心 |
成形类器官组合物及其制备方法
|
|
WO2020243613A1
(en)
|
2019-05-31 |
2020-12-03 |
Children's Hospital Medical Center |
Methods of generating and expanding hematopoietic stem cells
|
|
WO2020243661A1
(en)
|
2019-05-31 |
2020-12-03 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
JP7610339B2
(ja)
|
2019-06-04 |
2025-01-08 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
|
|
US20220236255A1
(en)
*
|
2019-06-28 |
2022-07-28 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Self-Contained Responsive Biological Systems and Methods
|
|
EP3994270A1
(en)
|
2019-07-02 |
2022-05-11 |
Fred Hutchinson Cancer Research Center |
Recombinant ad35 vectors and related gene therapy improvements
|
|
CN112168808B
(zh)
*
|
2019-07-02 |
2023-01-24 |
深圳市第二人民医院 |
一种基于crispr的细胞核靶向药物递送系统
|
|
CN114402071A
(zh)
*
|
2019-07-15 |
2022-04-26 |
新加坡国立大学 |
用于基因特异性脱甲基和激活的方法和组合物
|
|
US11980506B2
(en)
|
2019-07-29 |
2024-05-14 |
Augmedics Ltd. |
Fiducial marker
|
|
US12178666B2
(en)
|
2019-07-29 |
2024-12-31 |
Augmedics Ltd. |
Fiducial marker
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
US11116797B2
(en)
|
2019-09-05 |
2021-09-14 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
US11118196B2
(en)
*
|
2019-09-05 |
2021-09-14 |
Crispr Therapeutics Ag |
Universal donor cells
|
|
CA3151563A1
(en)
|
2019-09-20 |
2021-03-25 |
Feng Zhang |
Novel type vi crispr enzymes and systems
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN114846022B
(zh)
|
2019-10-17 |
2025-06-27 |
科沃施种子欧洲股份两合公司 |
通过阻抑基因的下调增强作物的疾病抗性
|
|
CN112690409A
(zh)
*
|
2019-10-23 |
2021-04-23 |
冯生财 |
一种香辣肉条、肉片的配方及其制作方法
|
|
IL293145A
(en)
|
2019-11-22 |
2022-07-01 |
Harvard College |
Ionic liquids for drug delivery
|
|
WO2021113270A1
(en)
|
2019-12-02 |
2021-06-10 |
Shape Therapeutics Inc. |
Therapeutic editing
|
|
WO2021113634A1
(en)
*
|
2019-12-05 |
2021-06-10 |
The Board Of Regents Of The University Of Texas |
Transgene cassettes designed to express a human mecp2 gene
|
|
US11382712B2
(en)
|
2019-12-22 |
2022-07-12 |
Augmedics Ltd. |
Mirroring in image guided surgery
|
|
WO2021146601A1
(en)
*
|
2020-01-17 |
2021-07-22 |
Jumpcode Genomics, Inc. |
Methods of sample normalization
|
|
WO2021226558A1
(en)
|
2020-05-08 |
2021-11-11 |
The Broad Institute, Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
EP4156913A1
(en)
|
2020-05-29 |
2023-04-05 |
KWS SAAT SE & Co. KGaA |
Plant haploid induction
|
|
US11389252B2
(en)
|
2020-06-15 |
2022-07-19 |
Augmedics Ltd. |
Rotating marker for image guided surgery
|
|
US12239385B2
(en)
|
2020-09-09 |
2025-03-04 |
Augmedics Ltd. |
Universal tool adapter
|
|
US12502163B2
(en)
|
2020-09-09 |
2025-12-23 |
Augmedics Ltd. |
Universal tool adapter for image-guided surgery
|
|
KR102424351B1
(ko)
*
|
2020-09-21 |
2022-08-05 |
한국과학기술원 |
파브알부민 유전자 발현 억제용 CRISPR/Cas9 시스템 및 이의 용도
|
|
CN114250228A
(zh)
*
|
2020-09-22 |
2022-03-29 |
广州瑞风生物科技有限公司 |
靶向CTGF基因的gRNA及其应用
|
|
EP4221761A4
(en)
*
|
2020-09-29 |
2025-02-26 |
Neuexcell Therapeutics Inc. |
Neurod1 combination vector
|
|
CA3203707A1
(en)
|
2020-12-31 |
2022-07-07 |
Alireza Rezania |
Universal donor cells
|
|
CN113355360A
(zh)
*
|
2021-05-28 |
2021-09-07 |
上海碧博生物医药科技有限公司 |
一种gs基因敲除cho-k1细胞株的构建方法及悬浮细胞单克隆化
|
|
US11896445B2
(en)
|
2021-07-07 |
2024-02-13 |
Augmedics Ltd. |
Iliac pin and adapter
|
|
EP4370679A4
(en)
*
|
2021-07-16 |
2025-11-12 |
Harvard College |
ACTIVATORS DIRECTING THE EXPRESSION OF MOTOR NEURONS
|
|
US12150821B2
(en)
|
2021-07-29 |
2024-11-26 |
Augmedics Ltd. |
Rotating marker and adapter for image-guided surgery
|
|
US20250179591A1
(en)
|
2021-07-30 |
2025-06-05 |
KWS SAAT SE & Co. KGaA |
Plants with improved digestibility and marker haplotypes
|
|
US20240382283A1
(en)
|
2021-08-18 |
2024-11-21 |
Augmedics Ltd. |
Augmented reality assistance for osteotomy and discectomy
|
|
IL311885A
(en)
|
2021-10-08 |
2024-06-01 |
Harvard College |
Ionic liquids for drug delivery
|
|
IL312452A
(en)
|
2021-11-01 |
2024-06-01 |
Tome Biosciences Inc |
A transformant has a single structure for the simultaneous transfer of a gene editing mechanism and a nucleic acid cargo
|
|
US20240408236A1
(en)
|
2021-11-26 |
2024-12-12 |
Epigenic Therapeutics, Inc. |
Method of modulating pcsk9 and uses thereof
|
|
US11845079B2
(en)
|
2021-12-08 |
2023-12-19 |
International Business Machines Corporation |
Integrated silicon platform for electronic biosensors
|
|
US20250057980A1
(en)
|
2021-12-22 |
2025-02-20 |
Tome Biosciences, Inc. |
Co-Delivery of a Gene Editor Construct and a Donor Template
|
|
EP4486890A1
(en)
|
2022-03-01 |
2025-01-08 |
CRISPR Therapeutics AG |
Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023203521A1
(en)
|
2022-04-21 |
2023-10-26 |
Augmedics Ltd. |
Systems and methods for medical image visualization
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
AU2023329149A1
(en)
|
2022-08-26 |
2025-02-20 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
|
EP4587881A1
(en)
|
2022-09-13 |
2025-07-23 |
Augmedics Ltd. |
Augmented reality eyewear for image-guided medical intervention
|
|
AU2023382738A1
(en)
|
2022-11-15 |
2025-05-29 |
Abbvie Inc. |
Anti-papp-a antibodies and methods of use thereof
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
WO2024193704A1
(en)
*
|
2023-03-22 |
2024-09-26 |
Huidagene Therapeutics Co., Ltd. |
Guide nucleic acids targeting dmd and uses thereof
|
|
CN121013904A
(zh)
|
2023-03-30 |
2025-11-25 |
儿童医院医学中心 |
临床级类器官
|
|
WO2024220741A1
(en)
|
2023-04-19 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for the production of libraries
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
AU2024270764A1
(en)
|
2023-05-15 |
2025-12-04 |
Nchroma Bio, Inc. |
Compositions and methods for epigenetic regulation of hbv gene expression
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
WO2024238977A2
(en)
|
2023-05-18 |
2024-11-21 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
|
WO2024263961A2
(en)
|
2023-06-23 |
2024-12-26 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
|
US20240425868A1
(en)
|
2023-06-26 |
2024-12-26 |
Flagship Pioneering Innovations Vii, Llc |
Engineered plasmodia and related methods
|
|
CN116790603B
(zh)
*
|
2023-08-18 |
2023-10-31 |
成都中科奥格生物科技有限公司 |
一种sgRNA、CRISPR/Cas9载体及其构建方法和用途
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025072803A1
(en)
|
2023-09-29 |
2025-04-03 |
Children's Hospital Medical Center |
Ntrk2 signaling-mediated alveolar capillary injury and repair
|
|
WO2025212920A1
(en)
|
2024-04-03 |
2025-10-09 |
Children's Hospital Medical Center |
Multi-zonal liver organoids
|
|
WO2025217202A1
(en)
|
2024-04-08 |
2025-10-16 |
Children's Hospital Medical Center |
Bile duct organoid
|
|
WO2025224107A1
(en)
|
2024-04-22 |
2025-10-30 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|