GB0024550D0 - - Google Patents
Info
- Publication number
- GB0024550D0 GB0024550D0 GBGB0024550.6A GB0024550A GB0024550D0 GB 0024550 D0 GB0024550 D0 GB 0024550D0 GB 0024550 A GB0024550 A GB 0024550A GB 0024550 D0 GB0024550 D0 GB 0024550D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- vector genome
- genomes
- relates
- present
- nois
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
- C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Molds, Cores, And Manufacturing Methods Thereof (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0024550.6A GB0024550D0 (enExample) | 2000-10-06 | 2000-10-06 | |
| EP09014156A EP2180057A1 (en) | 2000-10-06 | 2001-10-05 | Vector system |
| ES01972317T ES2348277T3 (es) | 2000-10-06 | 2001-10-05 | Vectores lentivíricos para el tratamiento de las enfermedades neurodegenerativas. |
| DK01972317.0T DK1337655T3 (da) | 2000-10-06 | 2001-10-05 | Lentivirusvektorer til behandling af neurodegenerative sygdomme |
| PCT/GB2001/004433 WO2002029065A2 (en) | 2000-10-06 | 2001-10-05 | Retroviral vectors containing internal ribosomal entry sites |
| AU2001292093A AU2001292093A1 (en) | 2000-10-06 | 2001-10-05 | Retroviral vectors containing internal ribosomal entry sites |
| EP01972317A EP1337655B1 (en) | 2000-10-06 | 2001-10-05 | Lentiviral vectors for the treatment of neurodegenerative diseases |
| AT01972317T ATE474058T1 (de) | 2000-10-06 | 2001-10-05 | Lentivirale vektoren zur behandlung neurodegenerativer krankheiten |
| PT01972317T PT1337655E (pt) | 2000-10-06 | 2001-10-05 | Vectores lentivirais para o tratamento de doenças neurodegenerativas |
| JP2002532634A JP4224295B2 (ja) | 2000-10-06 | 2001-10-05 | ベクターシステム |
| CA002424738A CA2424738A1 (en) | 2000-10-06 | 2001-10-05 | Retroviral vectors containing internal ribosomal entry sites |
| DE60142576T DE60142576D1 (de) | 2000-10-06 | 2001-10-05 | Lentivirale vektoren zur behandlung neurodegenerativer krankheiten |
| US10/408,456 US7259015B2 (en) | 2000-10-06 | 2003-04-07 | Vector system |
| US10/873,573 US7419829B2 (en) | 2000-10-06 | 2004-06-21 | Vector system |
| US11/486,914 US20070025970A1 (en) | 2000-10-06 | 2006-07-14 | Vector system |
| US12/168,563 US20090111106A1 (en) | 2000-10-06 | 2008-07-07 | Vector System |
| CY20101100888T CY1110817T1 (el) | 2000-10-06 | 2010-10-06 | Βραδεων ιων φορεις για τη θεραπεια νευροεκφυλιστικων ασθενειων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0024550.6A GB0024550D0 (enExample) | 2000-10-06 | 2000-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB0024550D0 true GB0024550D0 (enExample) | 2000-11-22 |
Family
ID=9900826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB0024550.6A Ceased GB0024550D0 (enExample) | 2000-10-06 | 2000-10-06 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7259015B2 (enExample) |
| EP (2) | EP2180057A1 (enExample) |
| JP (1) | JP4224295B2 (enExample) |
| AT (1) | ATE474058T1 (enExample) |
| AU (1) | AU2001292093A1 (enExample) |
| CA (1) | CA2424738A1 (enExample) |
| CY (1) | CY1110817T1 (enExample) |
| DE (1) | DE60142576D1 (enExample) |
| DK (1) | DK1337655T3 (enExample) |
| ES (1) | ES2348277T3 (enExample) |
| GB (1) | GB0024550D0 (enExample) |
| PT (1) | PT1337655E (enExample) |
| WO (1) | WO2002029065A2 (enExample) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7588757B2 (en) * | 2001-03-14 | 2009-09-15 | Genzyme Corporation | Methods of treating Parkinson's disease using recombinant adeno-associated virus virions |
| JP4598398B2 (ja) * | 2002-02-01 | 2010-12-15 | オックスフォード バイオメディカ (ユーケー) リミテッド | ウイルスベクター |
| US20080254512A1 (en) | 2006-11-02 | 2008-10-16 | Capon Daniel J | Hybrid immunoglobulins with moving parts |
| WO2009153563A1 (en) | 2008-06-18 | 2009-12-23 | Oxford Biomedica (Uk) Limited | Virus purification |
| US8829173B2 (en) * | 2008-09-26 | 2014-09-09 | Tocagen Inc. | Recombinant vectors |
| JP5559185B2 (ja) * | 2008-11-11 | 2014-07-23 | オックスフォード バイオメディカ(ユーケー)リミテッド | 方法 |
| US20120309816A1 (en) * | 2009-11-09 | 2012-12-06 | Genepod Therapeutics Ab | Novel viral vector construct for neuron specific optimized continuous DOPA synthesis in vivo |
| WO2011148194A1 (en) | 2010-05-28 | 2011-12-01 | Oxford Biomedica (Uk) Ltd | Delivery of lentiviral vectors to the brain |
| WO2012135389A2 (en) * | 2011-03-28 | 2012-10-04 | The Regents Of The University Of California | Host cells and methods for oxidizing aromatic amino acids |
| AU2012216792A1 (en) | 2011-09-12 | 2013-03-28 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies |
| EP2586461A1 (en) | 2011-10-27 | 2013-05-01 | Christopher L. Parks | Viral particles derived from an enveloped virus |
| JP6698114B2 (ja) * | 2011-10-28 | 2020-05-27 | オックスフォード バイオメディカ (ユーケー) リミテッド | 構築物 |
| US10400252B2 (en) | 2011-10-28 | 2019-09-03 | Oxford Biomedica (Uk) Ltd. | Catecholamine enzyme fusions |
| GB201118636D0 (en) | 2011-10-28 | 2011-12-07 | Oxford Biomedica Ltd | Nucleotide sequence |
| US9347065B2 (en) | 2012-03-29 | 2016-05-24 | International Aids Vaccine Initiative | Methods to improve vector expression and genetic stability |
| JP6279466B2 (ja) | 2012-04-27 | 2018-02-14 | Jcrファーマ株式会社 | 新規な発現ベクター |
| JP2015529466A (ja) * | 2012-09-14 | 2015-10-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 鎌状赤血球症の幹細胞遺伝子治療のためのレンチウイルスベクター |
| WO2014066700A1 (en) | 2012-10-25 | 2014-05-01 | Tocagen Inc. | Retroviral vector with mini-promoter cassette |
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| BR112015013784A2 (pt) | 2012-12-12 | 2017-07-11 | Massachusetts Inst Technology | aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas |
| US10106816B2 (en) | 2012-12-14 | 2018-10-23 | Case Western Reserve University | Genomic RNA packaging enhancer element |
| CN105683379A (zh) | 2013-06-17 | 2016-06-15 | 布罗德研究所有限公司 | 用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化 |
| DK3011031T3 (da) | 2013-06-17 | 2020-12-21 | Broad Inst Inc | Fremføring og anvendelse af crispr-cas-systemerne, vektorer og sammensætninger til levermålretning og -terapi |
| KR20250012194A (ko) | 2013-06-17 | 2025-01-23 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용 |
| WO2015048690A1 (en) * | 2013-09-27 | 2015-04-02 | The Regents Of The University Of California | Optimized small guide rnas and methods of use |
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| WO2015089351A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
| KR20160089530A (ko) | 2013-12-12 | 2016-07-27 | 더 브로드 인스티튜트, 인코퍼레이티드 | Hbv 및 바이러스 질병 및 질환을 위한 crisprcas 시스템 및 조성물의 전달,용도 및 치료적 적용 |
| IL289736B2 (en) | 2013-12-12 | 2025-09-01 | Massachusetts Inst Technology | Administration, use and therapeutic applications of CRISPR–Cas gene editing systems and gene editing preparations |
| WO2015089486A2 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| WO2015089473A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| EP3082853A2 (en) | 2013-12-20 | 2016-10-26 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
| WO2016028682A1 (en) | 2014-08-17 | 2016-02-25 | The Broad Institute Inc. | Genome editing using cas9 nickases |
| WO2016049163A2 (en) | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder |
| WO2016049258A2 (en) | 2014-09-25 | 2016-03-31 | The Broad Institute Inc. | Functional screening with optimized functional crispr-cas systems |
| EP3212788A2 (en) | 2014-10-27 | 2017-09-06 | The Broad Institute, Inc. | Compositions, methods and use of synthetic lethal screening |
| KR20170096998A (ko) | 2014-11-05 | 2017-08-25 | 보이저 테라퓨틱스, 인크. | 파킨슨병의 치료를 위한 aadc 폴리뉴클레오티드 |
| WO2016077689A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| WO2016094880A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs) |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| EP3230452B1 (en) | 2014-12-12 | 2025-06-11 | The Broad Institute, Inc. | Dead guides for crispr transcription factors |
| EP3985115A1 (en) | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| EP3234193B1 (en) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molecular biomarkers for cancer immunotherapy |
| US10993997B2 (en) | 2014-12-19 | 2021-05-04 | The Broad Institute, Inc. | Methods for profiling the t cell repertoire |
| EP3234192B1 (en) | 2014-12-19 | 2021-07-14 | The Broad Institute, Inc. | Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing |
| WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
| EP3702456A1 (en) | 2014-12-24 | 2020-09-02 | The Broad Institute, Inc. | Crispr having or associated with destabilization domains |
| ES2578903B1 (es) * | 2015-01-02 | 2017-07-07 | Instituto De Salud Carlos Iii | Vector lentiviral de expresión autolimitada |
| EP3268044A2 (en) | 2015-03-11 | 2018-01-17 | The Broad Institute Inc. | Prmt5 inhibitors for the treatment of cancer with reduced mtap activty |
| WO2016187508A2 (en) | 2015-05-20 | 2016-11-24 | The Broad Institute Inc. | Shared neoantigens |
| WO2016201368A1 (en) | 2015-06-10 | 2016-12-15 | The Broad Institute Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
| EP3666895A1 (en) | 2015-06-18 | 2020-06-17 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| WO2016205745A2 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Cell sorting |
| TWI813532B (zh) | 2015-06-18 | 2023-09-01 | 美商博得學院股份有限公司 | 降低脱靶效應的crispr酶突變 |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| WO2016205749A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| EP3331570A1 (en) * | 2015-08-03 | 2018-06-13 | Myodopa Limited | Systemic synthesis and regulation of l-dopa |
| EP3337908A4 (en) | 2015-08-18 | 2019-01-23 | The Broad Institute, Inc. | METHOD AND COMPOSITIONS FOR CHANGING THE FUNCTION AND STRUCTURE OF CHROMATIN GRINDING AND / OR DOMAINS |
| WO2017069958A2 (en) | 2015-10-09 | 2017-04-27 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| US12234454B2 (en) | 2015-10-22 | 2025-02-25 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2017074788A1 (en) | 2015-10-27 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for targeting cancer-specific sequence variations |
| WO2017075465A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3 |
| EP3368689B1 (en) | 2015-10-28 | 2020-06-17 | The Broad Institute, Inc. | Composition for modulating immune responses by use of immune cell gene signature |
| WO2017075451A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
| US12110490B2 (en) | 2015-12-18 | 2024-10-08 | The Broad Institute, Inc. | CRISPR enzymes and systems |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| EP3446119A1 (en) | 2016-04-18 | 2019-02-27 | The Broad Institute Inc. | Improved hla epitope prediction |
| US11286478B2 (en) | 2016-04-19 | 2022-03-29 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
| KR102424476B1 (ko) | 2016-04-19 | 2022-07-25 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신규한 crispr 효소 및 시스템 |
| CA3026110A1 (en) | 2016-04-19 | 2017-11-02 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| JP7045362B2 (ja) * | 2016-04-20 | 2022-03-31 | セントロ デ インベスティガシオンス エネルジェチカス メディオアンビエンタゥス イェ テクノロジカス オー.エイ. エム.ピー. | Pklrの遺伝子発現増強のための組成物および方法 |
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| WO2018005873A1 (en) | 2016-06-29 | 2018-01-04 | The Broad Institute Inc. | Crispr-cas systems having destabilization domain |
| DK3491384T3 (da) | 2016-08-01 | 2021-06-28 | Health Research Inc | Sammensætninger og fremgangsmåder til hurtig kloning af t-celle-receptorer |
| WO2018035388A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| CN110312799A (zh) | 2016-08-17 | 2019-10-08 | 博德研究所 | 新型crispr酶和系统 |
| WO2018049025A2 (en) | 2016-09-07 | 2018-03-15 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses |
| EP3510162A4 (en) * | 2016-09-08 | 2020-02-19 | Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A., M.P. | GENE THERAPY FOR PATIENTS WITH FANCONI ANEMIA |
| US12499971B2 (en) | 2016-09-28 | 2025-12-16 | The Broad Institute, Inc. | Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof |
| WO2018067991A1 (en) | 2016-10-07 | 2018-04-12 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| US11219695B2 (en) | 2016-10-20 | 2022-01-11 | Sangamo Therapeutics, Inc. | Methods and compositions for the treatment of Fabry disease |
| US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| EA201991809A1 (ru) | 2017-01-30 | 2020-02-05 | КВС ЗААТ СЕ & КО. КГаА | Сцепление матрицы для репарации с эндонуклеазами для геномной инженерии |
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- 2001-10-05 EP EP09014156A patent/EP2180057A1/en not_active Withdrawn
- 2001-10-05 AU AU2001292093A patent/AU2001292093A1/en not_active Abandoned
- 2001-10-05 PT PT01972317T patent/PT1337655E/pt unknown
- 2001-10-05 AT AT01972317T patent/ATE474058T1/de active
- 2001-10-05 WO PCT/GB2001/004433 patent/WO2002029065A2/en not_active Ceased
- 2001-10-05 JP JP2002532634A patent/JP4224295B2/ja not_active Expired - Lifetime
- 2001-10-05 EP EP01972317A patent/EP1337655B1/en not_active Expired - Lifetime
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- 2001-10-05 DK DK01972317.0T patent/DK1337655T3/da active
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| JP2004520016A (ja) | 2004-07-08 |
| WO2002029065A3 (en) | 2002-12-27 |
| PT1337655E (pt) | 2010-08-25 |
| JP4224295B2 (ja) | 2009-02-12 |
| DK1337655T3 (da) | 2010-09-20 |
| US7259015B2 (en) | 2007-08-21 |
| US20040013648A1 (en) | 2004-01-22 |
| ATE474058T1 (de) | 2010-07-15 |
| AU2001292093A1 (en) | 2002-04-15 |
| DE60142576D1 (de) | 2010-08-26 |
| US20090111106A1 (en) | 2009-04-30 |
| CY1110817T1 (el) | 2015-06-10 |
| CA2424738A1 (en) | 2002-04-11 |
| US20070025970A1 (en) | 2007-02-01 |
| EP1337655B1 (en) | 2010-07-14 |
| ES2348277T3 (es) | 2010-12-02 |
| EP2180057A1 (en) | 2010-04-28 |
| EP1337655A2 (en) | 2003-08-27 |
| WO2002029065A2 (en) | 2002-04-11 |
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