GB0024550D0 - - Google Patents
Info
- Publication number
- GB0024550D0 GB0024550D0 GBGB0024550.6A GB0024550A GB0024550D0 GB 0024550 D0 GB0024550 D0 GB 0024550D0 GB 0024550 A GB0024550 A GB 0024550A GB 0024550 D0 GB0024550 D0 GB 0024550D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- vector genome
- genomes
- relates
- present
- nois
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
- C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Molds, Cores, And Manufacturing Methods Thereof (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0024550.6A GB0024550D0 (enExample) | 2000-10-06 | 2000-10-06 | |
| ES01972317T ES2348277T3 (es) | 2000-10-06 | 2001-10-05 | Vectores lentivíricos para el tratamiento de las enfermedades neurodegenerativas. |
| AT01972317T ATE474058T1 (de) | 2000-10-06 | 2001-10-05 | Lentivirale vektoren zur behandlung neurodegenerativer krankheiten |
| EP01972317A EP1337655B1 (en) | 2000-10-06 | 2001-10-05 | Lentiviral vectors for the treatment of neurodegenerative diseases |
| PT01972317T PT1337655E (pt) | 2000-10-06 | 2001-10-05 | Vectores lentivirais para o tratamento de doenças neurodegenerativas |
| DE60142576T DE60142576D1 (de) | 2000-10-06 | 2001-10-05 | Lentivirale vektoren zur behandlung neurodegenerativer krankheiten |
| CA002424738A CA2424738A1 (en) | 2000-10-06 | 2001-10-05 | Retroviral vectors containing internal ribosomal entry sites |
| DK01972317.0T DK1337655T3 (da) | 2000-10-06 | 2001-10-05 | Lentivirusvektorer til behandling af neurodegenerative sygdomme |
| PCT/GB2001/004433 WO2002029065A2 (en) | 2000-10-06 | 2001-10-05 | Retroviral vectors containing internal ribosomal entry sites |
| AU2001292093A AU2001292093A1 (en) | 2000-10-06 | 2001-10-05 | Retroviral vectors containing internal ribosomal entry sites |
| JP2002532634A JP4224295B2 (ja) | 2000-10-06 | 2001-10-05 | ベクターシステム |
| EP09014156A EP2180057A1 (en) | 2000-10-06 | 2001-10-05 | Vector system |
| US10/408,456 US7259015B2 (en) | 2000-10-06 | 2003-04-07 | Vector system |
| US10/873,573 US7419829B2 (en) | 2000-10-06 | 2004-06-21 | Vector system |
| US11/486,914 US20070025970A1 (en) | 2000-10-06 | 2006-07-14 | Vector system |
| US12/168,563 US20090111106A1 (en) | 2000-10-06 | 2008-07-07 | Vector System |
| CY20101100888T CY1110817T1 (el) | 2000-10-06 | 2010-10-06 | Βραδεων ιων φορεις για τη θεραπεια νευροεκφυλιστικων ασθενειων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0024550.6A GB0024550D0 (enExample) | 2000-10-06 | 2000-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB0024550D0 true GB0024550D0 (enExample) | 2000-11-22 |
Family
ID=9900826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB0024550.6A Ceased GB0024550D0 (enExample) | 2000-10-06 | 2000-10-06 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7259015B2 (enExample) |
| EP (2) | EP2180057A1 (enExample) |
| JP (1) | JP4224295B2 (enExample) |
| AT (1) | ATE474058T1 (enExample) |
| AU (1) | AU2001292093A1 (enExample) |
| CA (1) | CA2424738A1 (enExample) |
| CY (1) | CY1110817T1 (enExample) |
| DE (1) | DE60142576D1 (enExample) |
| DK (1) | DK1337655T3 (enExample) |
| ES (1) | ES2348277T3 (enExample) |
| GB (1) | GB0024550D0 (enExample) |
| PT (1) | PT1337655E (enExample) |
| WO (1) | WO2002029065A2 (enExample) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7588757B2 (en) * | 2001-03-14 | 2009-09-15 | Genzyme Corporation | Methods of treating Parkinson's disease using recombinant adeno-associated virus virions |
| ES2634424T3 (es) * | 2002-02-01 | 2017-09-27 | Oxford Biomedica (Uk) Limited | Vector multicistrónico lentivírico |
| NZ576445A (en) * | 2006-11-02 | 2012-03-30 | Daniel J Capon | Hybrid immunoglobulins with moving parts |
| DK3192874T3 (da) | 2008-06-18 | 2019-12-16 | Oxford Biomedica Ltd | Virusoprensning |
| US8829173B2 (en) * | 2008-09-26 | 2014-09-09 | Tocagen Inc. | Recombinant vectors |
| WO2010055290A1 (en) * | 2008-11-11 | 2010-05-20 | Oxford Biomedica (Uk) Limited | Method |
| RU2606012C2 (ru) * | 2009-11-09 | 2017-01-10 | Дженепод Терапевтикс Аб | Новая вирусная векторная конструкция для нейронспецифического оптимизированного непрерывного синтеза dopa in vivo |
| EP2575894B1 (en) | 2010-05-28 | 2015-02-25 | Oxford Biomedica (UK) Ltd | Delivery of lentiviral vectors to the brain |
| WO2012135389A2 (en) * | 2011-03-28 | 2012-10-04 | The Regents Of The University Of California | Host cells and methods for oxidizing aromatic amino acids |
| EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| US10400252B2 (en) | 2011-10-28 | 2019-09-03 | Oxford Biomedica (Uk) Ltd. | Catecholamine enzyme fusions |
| GB201118636D0 (en) * | 2011-10-28 | 2011-12-07 | Oxford Biomedica Ltd | Nucleotide sequence |
| JP6698114B2 (ja) * | 2011-10-28 | 2020-05-27 | オックスフォード バイオメディカ (ユーケー) リミテッド | 構築物 |
| US9347065B2 (en) | 2012-03-29 | 2016-05-24 | International Aids Vaccine Initiative | Methods to improve vector expression and genetic stability |
| EP2848687B1 (en) | 2012-04-27 | 2017-09-13 | JCR Pharmaceuticals Co., Ltd. | Novel expression vector |
| JP2015529466A (ja) * | 2012-09-14 | 2015-10-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 鎌状赤血球症の幹細胞遺伝子治療のためのレンチウイルスベクター |
| JP6419706B2 (ja) | 2012-10-25 | 2018-11-07 | トカジェン インコーポレーテッド | ミニプロモーターカセットを含むレトロウイルスベクター |
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| WO2014093622A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| US10106816B2 (en) | 2012-12-14 | 2018-10-23 | Case Western Reserve University | Genomic RNA packaging enhancer element |
| EP3597755A1 (en) | 2013-06-17 | 2020-01-22 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components |
| SG11201510327TA (en) | 2013-06-17 | 2016-01-28 | Broad Inst Inc | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| KR20240172759A (ko) | 2013-06-17 | 2024-12-10 | 더 브로드 인스티튜트, 인코퍼레이티드 | 간의 표적화 및 치료를 위한 CRISPRCas 시스템, 벡터 및 조성물의 전달 및 용도 |
| US10822606B2 (en) | 2013-09-27 | 2020-11-03 | The Regents Of The University Of California | Optimized small guide RNAs and methods of use |
| US10801070B2 (en) | 2013-11-25 | 2020-10-13 | The Broad Institute, Inc. | Compositions and methods for diagnosing, evaluating and treating cancer |
| US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP3653229A1 (en) | 2013-12-12 | 2020-05-20 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing |
| CN105899658B (zh) | 2013-12-12 | 2020-02-18 | 布罗德研究所有限公司 | 针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用 |
| EP3080271B1 (en) | 2013-12-12 | 2020-02-12 | The Broad Institute, Inc. | Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems |
| WO2015089354A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders |
| EP3080259B1 (en) | 2013-12-12 | 2023-02-01 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation |
| JP7060324B2 (ja) | 2013-12-20 | 2022-04-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | ネオ抗原ワクチンによる併用療法 |
| EP3686279B1 (en) | 2014-08-17 | 2023-01-04 | The Broad Institute, Inc. | Genome editing using cas9 nickases |
| WO2016049163A2 (en) | 2014-09-24 | 2016-03-31 | The Broad Institute Inc. | Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder |
| WO2016049258A2 (en) | 2014-09-25 | 2016-03-31 | The Broad Institute Inc. | Functional screening with optimized functional crispr-cas systems |
| EP3212788A2 (en) | 2014-10-27 | 2017-09-06 | The Broad Institute, Inc. | Compositions, methods and use of synthetic lethal screening |
| CN112553229A (zh) | 2014-11-05 | 2021-03-26 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
| MX2017006217A (es) | 2014-11-14 | 2018-05-02 | Voyager Therapeutics Inc | Polinucleotidos moduladores. |
| EP3230452B1 (en) | 2014-12-12 | 2025-06-11 | The Broad Institute, Inc. | Dead guides for crispr transcription factors |
| WO2016094880A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs) |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| WO2016100974A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute Inc. | Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing |
| WO2016100975A1 (en) | 2014-12-19 | 2016-06-23 | Massachsetts Institute Ot Technology | Molecular biomarkers for cancer immunotherapy |
| EP4636401A2 (en) | 2014-12-19 | 2025-10-22 | The Broad Institute, Inc. | Methods for profiling the t-cell-receptor repertoire |
| WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
| CA2970370A1 (en) | 2014-12-24 | 2016-06-30 | Massachusetts Institute Of Technology | Crispr having or associated with destabilization domains |
| ES2578903B1 (es) * | 2015-01-02 | 2017-07-07 | Instituto De Salud Carlos Iii | Vector lentiviral de expresión autolimitada |
| US20180271891A1 (en) | 2015-03-11 | 2018-09-27 | The Broad Institute Inc. | Selective treatment of prmt5 dependent cancer |
| MX2017014700A (es) | 2015-05-20 | 2018-08-15 | Broad Inst Inc | Neoantigenos compartidos. |
| WO2016201368A1 (en) | 2015-06-10 | 2016-12-15 | The Broad Institute Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
| WO2016205749A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| MX392008B (es) | 2015-06-18 | 2025-03-21 | Broad Inst Inc | Mutaciones de la enzima crispr que reducen los efectos fuera del blanco |
| EP4159856A1 (en) | 2015-06-18 | 2023-04-05 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| WO2016205745A2 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Cell sorting |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| CN108136048A (zh) * | 2015-08-03 | 2018-06-08 | 米奥多巴有限公司 | 左旋多巴的系统合成和调节 |
| AU2016308339A1 (en) | 2015-08-18 | 2018-04-12 | Baylor College Of Medicine | Methods and compositions for altering function and structure of chromatin loops and/or domains |
| WO2017069958A2 (en) | 2015-10-09 | 2017-04-27 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| WO2017070605A1 (en) | 2015-10-22 | 2017-04-27 | The Broad Institute Inc. | Type vi-b crispr enzymes and systems |
| WO2017074788A1 (en) | 2015-10-27 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for targeting cancer-specific sequence variations |
| WO2017075465A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3 |
| WO2017075451A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
| WO2017075478A2 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures |
| US12110490B2 (en) | 2015-12-18 | 2024-10-08 | The Broad Institute, Inc. | CRISPR enzymes and systems |
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| EP3446119A1 (en) | 2016-04-18 | 2019-02-27 | The Broad Institute Inc. | Improved hla epitope prediction |
| WO2017189308A1 (en) | 2016-04-19 | 2017-11-02 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| EP3445853A1 (en) | 2016-04-19 | 2019-02-27 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
| KR20260004568A (ko) | 2016-04-19 | 2026-01-08 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신규한 crispr 효소 및 시스템 |
| CN109641063B (zh) * | 2016-04-20 | 2022-11-15 | 能源环境和技术研究中心O.A., M.P. | 用于增强pklr的基因表达的组合物和方法 |
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| US20210222164A1 (en) | 2016-06-29 | 2021-07-22 | The Broad Institute, Inc. | Crispr-cas systems having destabilization domain |
| CN109804246B (zh) * | 2016-08-01 | 2022-05-17 | 健康研究公司 | 用于快速克隆t细胞受体的组合物和方法 |
| WO2018035388A1 (en) | 2016-08-17 | 2018-02-22 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| CN110312799A (zh) | 2016-08-17 | 2019-10-08 | 博德研究所 | 新型crispr酶和系统 |
| WO2018049025A2 (en) | 2016-09-07 | 2018-03-15 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses |
| CN110536966A (zh) * | 2016-09-08 | 2019-12-03 | 能源环境和技术研究中心O.A.,M.P. | 用于范可尼贫血患者的基因疗法 |
| WO2018064208A1 (en) | 2016-09-28 | 2018-04-05 | The Broad Institute, Inc. | Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof |
| WO2018067991A1 (en) | 2016-10-07 | 2018-04-12 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| JP7042263B2 (ja) | 2016-10-20 | 2022-03-25 | サンガモ セラピューティクス, インコーポレイテッド | ファブリー病の治療のための方法および組成物 |
| WO2018140391A1 (en) | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| DK3574101T5 (da) | 2017-01-30 | 2024-09-02 | Kws Saat Se & Co Kgaa | Reparationsskabelonbinding til endonukleaser til genommodifikation |
| SI3580561T1 (sl) | 2017-02-12 | 2024-04-30 | Biontech Us Inc. | Metode, osnovane na hla, in njihove sestave ter uporabe |
| CN120330163A (zh) | 2017-03-15 | 2025-07-18 | 博德研究所 | 新型cas13b直向同源物crispr酶和系统 |
| CA3059757A1 (en) | 2017-04-12 | 2018-10-18 | Massachusetts Institute Of Technology | Novel type vi crispr orthologs and systems |
| WO2018191750A2 (en) | 2017-04-14 | 2018-10-18 | The Broad Institute Inc. | Novel delivery of large payloads |
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- 2000-10-06 GB GBGB0024550.6A patent/GB0024550D0/en not_active Ceased
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2001
- 2001-10-05 EP EP09014156A patent/EP2180057A1/en not_active Withdrawn
- 2001-10-05 EP EP01972317A patent/EP1337655B1/en not_active Expired - Lifetime
- 2001-10-05 DE DE60142576T patent/DE60142576D1/de not_active Expired - Lifetime
- 2001-10-05 ES ES01972317T patent/ES2348277T3/es not_active Expired - Lifetime
- 2001-10-05 AU AU2001292093A patent/AU2001292093A1/en not_active Abandoned
- 2001-10-05 PT PT01972317T patent/PT1337655E/pt unknown
- 2001-10-05 WO PCT/GB2001/004433 patent/WO2002029065A2/en not_active Ceased
- 2001-10-05 AT AT01972317T patent/ATE474058T1/de active
- 2001-10-05 CA CA002424738A patent/CA2424738A1/en not_active Abandoned
- 2001-10-05 DK DK01972317.0T patent/DK1337655T3/da active
- 2001-10-05 JP JP2002532634A patent/JP4224295B2/ja not_active Expired - Lifetime
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2003
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2006
- 2006-07-14 US US11/486,914 patent/US20070025970A1/en not_active Abandoned
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2008
- 2008-07-07 US US12/168,563 patent/US20090111106A1/en not_active Abandoned
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- 2010-10-06 CY CY20101100888T patent/CY1110817T1/el unknown
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| JP2004520016A (ja) | 2004-07-08 |
| CA2424738A1 (en) | 2002-04-11 |
| ATE474058T1 (de) | 2010-07-15 |
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| EP1337655B1 (en) | 2010-07-14 |
| US7259015B2 (en) | 2007-08-21 |
| US20040013648A1 (en) | 2004-01-22 |
| EP2180057A1 (en) | 2010-04-28 |
| US20090111106A1 (en) | 2009-04-30 |
| CY1110817T1 (el) | 2015-06-10 |
| JP4224295B2 (ja) | 2009-02-12 |
| EP1337655A2 (en) | 2003-08-27 |
| ES2348277T3 (es) | 2010-12-02 |
| US20070025970A1 (en) | 2007-02-01 |
| AU2001292093A1 (en) | 2002-04-15 |
| PT1337655E (pt) | 2010-08-25 |
| DK1337655T3 (da) | 2010-09-20 |
| WO2002029065A2 (en) | 2002-04-11 |
| DE60142576D1 (de) | 2010-08-26 |
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