DK0598029T3 - Retrovirale vektorer indeholdende interne ribosome indgangssteder - Google Patents

Retrovirale vektorer indeholdende interne ribosome indgangssteder

Info

Publication number
DK0598029T3
DK0598029T3 DK92917724T DK92917724T DK0598029T3 DK 0598029 T3 DK0598029 T3 DK 0598029T3 DK 92917724 T DK92917724 T DK 92917724T DK 92917724 T DK92917724 T DK 92917724T DK 0598029 T3 DK0598029 T3 DK 0598029T3
Authority
DK
Denmark
Prior art keywords
ribosome entry
internal ribosome
entry sites
vectors containing
retroviral vectors
Prior art date
Application number
DK92917724T
Other languages
English (en)
Inventor
W French Anderson
Richard A Morgan
Larry Couture
Original Assignee
W French Anderson
Richard A Morgan
Larry Couture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24981978&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0598029(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by W French Anderson, Richard A Morgan, Larry Couture filed Critical W French Anderson
Application granted granted Critical
Publication of DK0598029T3 publication Critical patent/DK0598029T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32211—Cardiovirus, e.g. encephalomyocarditis virus
    • C12N2770/32222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Traffic Control Systems (AREA)
  • Fittings On The Vehicle Exterior For Carrying Loads, And Devices For Holding Or Mounting Articles (AREA)
  • Optical Radar Systems And Details Thereof (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
  • Road Signs Or Road Markings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK92917724T 1991-08-07 1992-08-06 Retrovirale vektorer indeholdende interne ribosome indgangssteder DK0598029T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74174091A 1991-08-07 1991-08-07
PCT/US1992/006572 WO1993003143A1 (en) 1991-08-07 1992-08-06 Retroviral vectors containing internal ribosome entry sites

Publications (1)

Publication Number Publication Date
DK0598029T3 true DK0598029T3 (da) 2002-05-27

Family

ID=24981978

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92917724T DK0598029T3 (da) 1991-08-07 1992-08-06 Retrovirale vektorer indeholdende interne ribosome indgangssteder

Country Status (8)

Country Link
EP (1) EP0598029B1 (da)
JP (1) JP3378962B2 (da)
AT (1) ATE213779T1 (da)
CA (1) CA2114416C (da)
DE (1) DE69232438T2 (da)
DK (1) DK0598029T3 (da)
ES (1) ES2173082T3 (da)
WO (1) WO1993003143A1 (da)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
DE4228457A1 (de) * 1992-08-27 1994-04-28 Beiersdorf Ag Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen
US5589582A (en) * 1992-10-27 1996-12-31 Biotransplant, Inc. Polynucleotides en coding porcine cytokines
BE1006437A3 (fr) * 1992-12-10 1994-08-30 Company S A Z Sequence nucleotidique destinee au traitement du cancer et des infections.
CA2162056A1 (en) * 1993-01-20 1994-11-10 Christian A. Le Guern Retroviral vectors capable of expressing multimeric proteins from multiple translational initiation sites
US5738985A (en) * 1993-04-02 1998-04-14 Ribogene, Inc. Method for selective inactivation of viral replication
US6824976B1 (en) 1993-04-02 2004-11-30 Rigel Pharmaceuticals, Inc. Method for selective inactivation of viral replication
CA2161095A1 (en) * 1993-04-20 1994-10-27 Solis Therapeutics, Inc. Methods and materials for treatment of individuals infected with intracellular infectious agents
GB9320548D0 (en) * 1993-10-06 1993-11-24 Sandoz Ltd Improvements in or relating to organic compounds
JPH09505474A (ja) * 1993-11-26 1997-06-03 ブリテイツシユ・テクノロジー・グループ・リミテツド 翻訳エンハンサーｄｎａ
US6995008B1 (en) 1994-03-07 2006-02-07 Merck & Co., Inc. Coordinate in vivo gene expression
FR2722208B1 (fr) * 1994-07-05 1996-10-04 Inst Nat Sante Rech Med Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
AU780164B2 (en) * 1994-09-13 2005-03-03 Transgene S.A. Novel implant and novel vector for the treatment of acquired diseases
FR2724320B1 (fr) * 1994-09-13 1996-12-20 Transgene Sa Nouvel implant pour le traitement des maladies acquises
US5518042A (en) * 1994-09-16 1996-05-21 Huyck Licensco, Inc. Papermaker's forming fabric with additional cross machine direction locator and fiber supporting yarns
AT403167B (de) * 1994-11-14 1997-11-25 Immuno Ag Selektion und expression von fremdproteinen mittels eines selektions-amplifikations-systems
DE19514310A1 (de) * 1995-04-18 1996-10-24 Univ Ludwigs Albert Vektoren zur Transfektion von eukaryotischen Zellen, deren Verwendung und damit transfizierte Zielzellen
DK0832207T3 (da) * 1995-06-02 2000-11-06 M & E Biotech As Fremgangsmåde til identifikation af biologisk aktive peptider og nukleinsyrer
GB9517263D0 (en) * 1995-08-23 1995-10-25 Cancer Res Campaign Tech Expression systems
EP0857217B1 (en) * 1995-10-16 2005-04-13 Dana-Farber Cancer Institute Novel expression vectors and methods of use
GB9524973D0 (en) * 1995-12-06 1996-02-07 Lynxvale Ltd Viral vectors
EP1295952A3 (en) 1996-01-23 2003-07-09 The Board of Trustees of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
US6365344B1 (en) 1996-01-23 2002-04-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
FR2751345B1 (fr) * 1996-07-16 1998-09-18 Univ Paris Curie Lignees d'encapsidation hautement productrices
FR2755975B1 (fr) * 1996-11-15 1999-05-07 Rhone Poulenc Rorer Sa Virus recombinants bicistroniques utiles pour le traitement de pathologies liees aux dyslipoproteinemies
FR2762615B1 (fr) 1997-04-28 1999-07-16 Inst Nat Sante Rech Med Nouveau site interne d'entree des ribosomes et vecteur le contenant
EP0938904A1 (en) * 1998-02-09 1999-09-01 Leuven Research & Development vzw Mammalian cell transduction for use in gene therapy
CA2289918A1 (en) * 1997-05-16 1998-11-26 Leuven Research & Development Vzw Mammalian cell transduction for use in gene therapy
FI110323B (fi) * 1997-06-02 2002-12-31 Timo Korpela Rekombinanttikonstrukti geenin ilmentämisen lisäämiseksi kasveissa
DK1115290T3 (da) 1998-10-01 2009-06-22 Univ Southern California Retroviralt gentilförselssystem og fremgangsmåder til anvendelse heraf
JP2002542834A (ja) * 1999-04-29 2002-12-17 アールフス・ユニバーシティー レトロウイルスベクターでのｉｒｅｓ転写カセットからの異種遺伝子群の発現
WO2002002783A2 (en) 2000-07-03 2002-01-10 Gala Design, Inc. Expression vectors
US6852510B2 (en) 2000-07-03 2005-02-08 Gala Design Inc Host cells containing multiple integrating vectors
US6677500B2 (en) 2000-08-15 2004-01-13 Board Of Trustees Of The University Of Illinois Ungulates expressing exogenous IGF-I in their milk
US7419829B2 (en) 2000-10-06 2008-09-02 Oxford Biomedica (Uk) Limited Vector system
GB0024550D0 (da) 2000-10-06 2000-11-22 Oxford Biomedica Ltd
DE60044301D1 (de) 2000-12-22 2010-06-10 Agronomique Inst Nat Rech Positionsunabhängige und gewebespezifische Expression eines Transgens in der Milch eines Transgen-Tieres
US20040038304A1 (en) 2002-03-28 2004-02-26 Gala Design, Inc. Antibody libraries
US20050014932A1 (en) 2003-05-15 2005-01-20 Iogenetics, Llc Targeted biocides
CA2615983A1 (en) 2005-07-21 2007-02-01 Abbott Laboratories Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis
WO2008066658A2 (en) 2006-11-03 2008-06-05 The Trustees Of Princeton University Engineered cellular pathways for programmed autoregulation of differentiation
WO2013078433A1 (en) 2011-11-23 2013-05-30 University Of Hawaii Auto-processing domains for polypeptide expression
JP6279466B2 (ja) 2012-04-27 2018-02-14 Ｊｃｒファーマ株式会社 新規な発現ベクター
CN104884627A (zh) 2012-10-25 2015-09-02 托卡根公司 具有小型启动子盒的逆转录病毒载体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04500004A (ja) * 1988-07-29 1992-01-09 ザイモジェネティクス，インコーポレイティド 真核細胞におけるポリシストロン性メッセージの高率翻訳

Also Published As

Publication number Publication date
ATE213779T1 (de) 2002-03-15
EP0598029A4 (en) 1996-04-17
CA2114416A1 (en) 1993-02-18
EP0598029B1 (en) 2002-02-27
WO1993003143A1 (en) 1993-02-18
DE69232438T2 (de) 2002-10-10
JP3378962B2 (ja) 2003-02-17
JPH06509713A (ja) 1994-11-02
EP0598029A1 (en) 1994-05-25
CA2114416C (en) 1998-07-07
DE69232438D1 (de) 2002-04-04
ES2173082T3 (es) 2002-10-16

Similar Documents

Publication Publication Date Title
DK0598029T3 (da) Retrovirale vektorer indeholdende interne ribosome indgangssteder
WO1991018047A3 (en) Mammalian expression of the bmp-2 family
IE44226L (en) Hentriakontapeptides
EA200501444A1 (ru) Экспрессирующие векторы, содержащие ie2-промотор mcmv
FI923280A0 (fi) Aminosubstituerade piperazinderivat.
DE69429631T2 (de) Conotoxinpeptide
ES2044950T3 (es) Un procedimiento para producir una proteina.
ATE133183T1 (de) Peptide, die von der faktor viii-bindungsdomäne des von willebrand-faktors abgeleitet sind
DE69327443T2 (de) Multiplexer, an dessen Eingang mehrere identische Signale verschiedener Phasenlage anliegen
MX18879A (es) Analogos de la prostaglandina de amida heterociclica substituida con 7-oxabicicloheptilo.
DK0852587T3 (da) Syntetiske peptider der inhiberer IL-6-aktivitet
BR9407693A (pt) Sequência nucleotídica vetor composiçao farmacêutica utilizaçao do vetor e de um composto
NZ224677A (en) Anticoagulant peptides
ES2060689T3 (es) Alcoholes peptidicos anticoagulantes.
DE68902556D1 (de) Bogenzufuehrung.
GR3021660T3 (en) Anticoagulant peptides
ES2131041T3 (es) Peptidos anticoagulantes.
IT8322114A0 (it) Composti di peptidi sostituiti.
EP0127727A3 (en) Substituted n-(omega-(1h-imidazol-1-yl)alkyl)) amides
EP0179412A3 (en) Antigenic peptide compounds
IT8722485A0 (it) Preparazione di composti epossidici a configurazione cis e trans apartire da miscele degli stereoisomeri olefinici corrispondenti.
SE9500901D0 (sv) Miljövänlig tyngd för sportfiske
MX9202871A (es) 5-(amino substituidas)-8-(fenil substituidas)-3h,6h-1,4,5a,8a-tetraazaacenaf-tilen-3-onas.
DE3484304D1 (de) Streptokinase kodierende rekombinante vektoren.
JPS6416792A (en) Guanidine related compound containing tetraphenylborate ion, its production and use thereof in peptide synthesis