DK0852587T3 - Syntetiske peptider der inhiberer IL-6-aktivitet - Google Patents

Syntetiske peptider der inhiberer IL-6-aktivitet

Info

Publication number
DK0852587T3
DK0852587T3 DK96931220T DK96931220T DK0852587T3 DK 0852587 T3 DK0852587 T3 DK 0852587T3 DK 96931220 T DK96931220 T DK 96931220T DK 96931220 T DK96931220 T DK 96931220T DK 0852587 T3 DK0852587 T3 DK 0852587T3
Authority
DK
Denmark
Prior art keywords
inhibit
activity
synthetic peptides
subunit
peptides derived
Prior art date
Application number
DK96931220T
Other languages
English (en)
Inventor
Judith Chebath
Hubert Halimi
Michel Revel
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11545395A external-priority patent/IL115453A0/xx
Priority claimed from IL11809796A external-priority patent/IL118097A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of DK0852587T3 publication Critical patent/DK0852587T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK96931220T 1995-09-28 1996-09-26 Syntetiske peptider der inhiberer IL-6-aktivitet DK0852587T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11545395A IL115453A0 (en) 1995-09-28 1995-09-28 Synthetic peptides that inhibit il-6 activity
IL11809796A IL118097A0 (en) 1996-05-01 1996-05-01 Synthetic peptides that inhibit IL-6 activity
PCT/IL1996/000119 WO1997013781A2 (en) 1995-09-28 1996-09-26 Synthetic peptides that inhibit il-6 activity

Publications (1)

Publication Number Publication Date
DK0852587T3 true DK0852587T3 (da) 2009-06-08

Family

ID=26323140

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96931220T DK0852587T3 (da) 1995-09-28 1996-09-26 Syntetiske peptider der inhiberer IL-6-aktivitet

Country Status (12)

Country Link
US (1) US6172042B1 (da)
EP (1) EP0852587B1 (da)
JP (1) JP3913273B2 (da)
AT (1) ATE423790T1 (da)
AU (1) AU709585B2 (da)
CA (1) CA2230949C (da)
DE (1) DE69637845D1 (da)
DK (1) DK0852587T3 (da)
ES (1) ES2319340T3 (da)
IL (1) IL123815A (da)
PT (1) PT852587E (da)
WO (1) WO1997013781A2 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
EP0972780A1 (en) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides
WO2001016166A2 (en) 1999-08-27 2001-03-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
FR2828104B1 (fr) * 2001-08-01 2005-06-24 Chu Montpellier Utilisation d'inhibiteurs du facteur de croissance epidermique liant l'heparine ou d'inhibiteurs de ses recepteurs pour la preparation de medicaments utiles pour traiter le myelome
US8629244B2 (en) 2006-08-18 2014-01-14 Ablynx N.V. Interleukin-6 receptor binding polypeptides
WO2008113597A1 (en) * 2007-03-22 2008-09-25 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh Peptides for treating multiple myeloma
CA2724279C (en) * 2008-05-13 2017-03-07 Novimmune S.A. Anti-il-6/il-6r antibodies and methods of use thereof
KR20110091780A (ko) 2008-11-25 2011-08-12 앨더 바이오파마슈티컬즈, 인코포레이티드 악액질, 쇠약, 피로 및／또는 발열을 예방하거나 치료하는 ｉｌ­６의 길항제
US10618964B2 (en) 2009-04-10 2020-04-14 Ablynx N.V. Nanobody against IL-6R
CN105399828B (zh) 2009-04-10 2021-01-15 埃博灵克斯股份有限公司 用于治疗il-6r相关疾病和病症的改进的针对il-6r的氨基酸序列和包含其的多肽
AU2011332817A1 (en) 2010-11-23 2013-06-13 Alder Biopharmaceuticals, Inc. Anti-IL-6 antibodies for the treatment of anemia
AU2012311443B2 (en) 2011-09-23 2016-12-01 Ablynx Nv Prolonged inhibition of interleukin-6 mediated signaling
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
US10633423B2 (en) 2014-06-13 2020-04-28 Affibody Ab IL-6-binding polypeptide complex
CN106488930B (zh) * 2014-06-13 2021-11-02 阿菲博迪公司 新型多肽
JP2017534617A (ja) 2014-10-21 2017-11-24 アブリンクス エン．ヴェー． Ｉｌ−６ｒ関連疾患の処置
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
CN116715735B (zh) * 2023-05-24 2024-05-10 湖南中晟全肽生物科技股份有限公司 抑制il-6与il-6r结合的多肽及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2026881A1 (en) * 1989-02-08 1990-08-09 Masao Tanihara Peptide and adsorbent thereof immobilized on carrier
US5210075A (en) * 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
IT1274350B (it) * 1994-12-06 1997-07-17 Angeletti P Ist Richerche Bio Antagonisti di interleuchina-6(il-6) che consistono di forme solubili del ricettore alfa di il-6, mutate nell'interfaccia che si lega a gp 130

Also Published As

Publication number Publication date
EP0852587A2 (en) 1998-07-15
EP0852587B1 (en) 2009-02-25
US6172042B1 (en) 2001-01-09
IL123815A0 (en) 1998-10-30
WO1997013781A3 (en) 1997-05-15
JP3913273B2 (ja) 2007-05-09
AU709585B2 (en) 1999-09-02
ATE423790T1 (de) 2009-03-15
DE69637845D1 (de) 2009-04-09
WO1997013781A2 (en) 1997-04-17
PT852587E (pt) 2009-03-10
CA2230949A1 (en) 1997-04-17
AU6999396A (en) 1997-04-30
IL123815A (en) 2007-05-15
JP2000500644A (ja) 2000-01-25
CA2230949C (en) 2009-11-17
ES2319340T3 (es) 2009-05-06

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