ATE423790T1 - Synthetische peptide mit il-6 aktivitäthemmung - Google Patents

Synthetische peptide mit il-6 aktivitäthemmung

Info

Publication number
ATE423790T1
ATE423790T1 AT96931220T AT96931220T ATE423790T1 AT E423790 T1 ATE423790 T1 AT E423790T1 AT 96931220 T AT96931220 T AT 96931220T AT 96931220 T AT96931220 T AT 96931220T AT E423790 T1 ATE423790 T1 AT E423790T1
Authority
AT
Austria
Prior art keywords
synthetic peptides
activity inhibition
activity
inhibition
subunit
Prior art date
Application number
AT96931220T
Other languages
English (en)
Inventor
Judith Chebath
Hubert Halimi
Michel Revel
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11545395A external-priority patent/IL115453A0/xx
Priority claimed from IL11809796A external-priority patent/IL118097A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE423790T1 publication Critical patent/ATE423790T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96931220T 1995-09-28 1996-09-26 Synthetische peptide mit il-6 aktivitäthemmung ATE423790T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11545395A IL115453A0 (en) 1995-09-28 1995-09-28 Synthetic peptides that inhibit il-6 activity
IL11809796A IL118097A0 (en) 1996-05-01 1996-05-01 Synthetic peptides that inhibit IL-6 activity

Publications (1)

Publication Number Publication Date
ATE423790T1 true ATE423790T1 (de) 2009-03-15

Family

ID=26323140

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96931220T ATE423790T1 (de) 1995-09-28 1996-09-26 Synthetische peptide mit il-6 aktivitäthemmung

Country Status (12)

Country Link
US (1) US6172042B1 (de)
EP (1) EP0852587B1 (de)
JP (1) JP3913273B2 (de)
AT (1) ATE423790T1 (de)
AU (1) AU709585B2 (de)
CA (1) CA2230949C (de)
DE (1) DE69637845D1 (de)
DK (1) DK0852587T3 (de)
ES (1) ES2319340T3 (de)
IL (1) IL123815A (de)
PT (1) PT852587E (de)
WO (1) WO1997013781A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
EP0972780A1 (de) * 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6-Antagonistische Peptide
AU7078200A (en) * 1999-08-27 2001-03-26 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Polypeptides, comprising il-6 ligand-binding receptor domains and related nucleic acids, antibodies, compositions, and methods of use
FR2828104B1 (fr) * 2001-08-01 2005-06-24 Chu Montpellier Utilisation d'inhibiteurs du facteur de croissance epidermique liant l'heparine ou d'inhibiteurs de ses recepteurs pour la preparation de medicaments utiles pour traiter le myelome
AU2007285695B2 (en) 2006-08-18 2012-05-24 Ablynx N.V. Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling
WO2008113597A1 (en) * 2007-03-22 2008-09-25 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh Peptides for treating multiple myeloma
MX2010012031A (es) * 2008-05-13 2011-01-20 Novimmune Sa Anticuerpos anti-il-6/il-6r y metodos de uso de los mismos.
WO2010065079A2 (en) 2008-11-25 2010-06-10 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
EP2417162A2 (de) 2009-04-10 2012-02-15 Ablynx N.V. Verbesserte, gegen il-6r gerichtete amiinosäuresequenzen und polypeptide, die diese enthalten, zur behandlung von krankheiten und erkrankungen, die mit il-6r in zusammenhang stehen
BRPI1013877A2 (pt) 2009-04-10 2017-08-15 Ablynx Nv Sequências de aminoácidos melhoradas contra il-6r e polipeptídeos que compreendem os mesmos para o tratamento de doenças e distúrbios relacionados com il-6r
DK2643018T3 (da) 2010-11-23 2021-01-18 Vitaeris Inc Anti-il-6-antistoffer til behandling af oral mucositis
EP2747782B1 (de) 2011-09-23 2018-01-17 Ablynx NV Verlängerte inhibition der interleukin-6-vermittelten signalisierung
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
WO2015189431A1 (en) * 2014-06-13 2015-12-17 Affibody Ab New polypeptide
CN106488930B (zh) * 2014-06-13 2021-11-02 阿菲博迪公司 新型多肽
EP3209327A1 (de) 2014-10-21 2017-08-30 Ablynx N.V. Behandlung von il-6r-bedingten erkrankungen
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
CN116715735B (zh) * 2023-05-24 2024-05-10 湖南中晟全肽生物科技股份有限公司 抑制il-6与il-6r结合的多肽及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426857A4 (en) * 1989-02-08 1991-10-16 Kuraray Co. Ltd. Peptide and adsorbent comprising same immobilized on carrier
US5210075A (en) * 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
IT1274350B (it) * 1994-12-06 1997-07-17 Angeletti P Ist Richerche Bio Antagonisti di interleuchina-6(il-6) che consistono di forme solubili del ricettore alfa di il-6, mutate nell'interfaccia che si lega a gp 130

Also Published As

Publication number Publication date
JP2000500644A (ja) 2000-01-25
DE69637845D1 (de) 2009-04-09
ES2319340T3 (es) 2009-05-06
PT852587E (pt) 2009-03-10
WO1997013781A3 (en) 1997-05-15
CA2230949C (en) 2009-11-17
WO1997013781A2 (en) 1997-04-17
EP0852587A2 (de) 1998-07-15
CA2230949A1 (en) 1997-04-17
AU709585B2 (en) 1999-09-02
IL123815A0 (en) 1998-10-30
EP0852587B1 (de) 2009-02-25
US6172042B1 (en) 2001-01-09
JP3913273B2 (ja) 2007-05-09
DK0852587T3 (da) 2009-06-08
AU6999396A (en) 1997-04-30
IL123815A (en) 2007-05-15

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