EP0706319A4 - Retroviral vectors capable of expressing multimeric proteins from multiple translational initiation sites - Google Patents
Retroviral vectors capable of expressing multimeric proteins from multiple translational initiation sitesInfo
- Publication number
- EP0706319A4 EP0706319A4 EP94909464A EP94909464A EP0706319A4 EP 0706319 A4 EP0706319 A4 EP 0706319A4 EP 94909464 A EP94909464 A EP 94909464A EP 94909464 A EP94909464 A EP 94909464A EP 0706319 A4 EP0706319 A4 EP 0706319A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- retroviral vectors
- translational initiation
- vectors capable
- initiation sites
- multimeric proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
- C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/80—Vectors comprising a special translation-regulating system from vertebrates
- C12N2840/85—Vectors comprising a special translation-regulating system from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US647893A | 1993-01-20 | 1993-01-20 | |
US6478 | 1993-05-05 | ||
PCT/US1994/000650 WO1994024870A1 (en) | 1993-01-20 | 1994-01-17 | Retroviral vectors capable of expressing multimeric proteins from multiple translational initiation sites |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0706319A1 EP0706319A1 (en) | 1996-04-17 |
EP0706319A4 true EP0706319A4 (en) | 1998-04-22 |
Family
ID=21721102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94909464A Withdrawn EP0706319A4 (en) | 1993-01-20 | 1994-01-17 | Retroviral vectors capable of expressing multimeric proteins from multiple translational initiation sites |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0706319A4 (en) |
JP (1) | JPH08510636A (en) |
AU (1) | AU6230394A (en) |
CA (1) | CA2162056A1 (en) |
IL (1) | IL108383A0 (en) |
WO (1) | WO1994024870A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT403167B (en) * | 1994-11-14 | 1997-11-25 | Immuno Ag | SELECTION AND EXPRESSION OF FOREIGN PROTEINS BY MEANS OF A SELECTION-AMPLIFICATION SYSTEM |
DE19514310A1 (en) * | 1995-04-18 | 1996-10-24 | Univ Ludwigs Albert | Vectors for the transfection of eukaryotic cells, their use and thus transfected target cells |
GB9517263D0 (en) * | 1995-08-23 | 1995-10-25 | Cancer Res Campaign Tech | Expression systems |
WO1997029201A2 (en) * | 1996-02-07 | 1997-08-14 | Max-Delbrück-Centrum für Molekulare Medizin | Retroviral vector for the gene transfer of an il6 antagonist in human haematopoietic stem cells |
US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
WO1998011241A1 (en) * | 1996-09-16 | 1998-03-19 | Merck Patent Gmbh | Oligocistronic expression system for the production of heteromeric proteins |
AU1387299A (en) * | 1997-11-12 | 1999-05-31 | Valentis, Inc. | Expression plasmids for multiepitope nucleic acid-based vaccines |
US6610508B1 (en) | 1999-03-08 | 2003-08-26 | Anadys Pharmaceuticals, Inc. | Translation driver system and methods for use thereof |
BR0107943A (en) * | 2000-01-28 | 2003-01-28 | Scripps Research Inst | Synthetic Internal Ribosome Entry Sites and Methods of Identifying Them |
US7468275B2 (en) * | 2000-01-28 | 2008-12-23 | The Scripps Research Institute | Synthetic internal ribosome entry sites and methods of identifying same |
EP1299556A2 (en) * | 2000-07-03 | 2003-04-09 | Gala Design, Inc. | Host cells containing multiple integrating vectors |
US6852510B2 (en) | 2000-07-03 | 2005-02-08 | Gala Design Inc | Host cells containing multiple integrating vectors |
AU2001270252B2 (en) * | 2000-07-03 | 2007-02-08 | Catalent Pharma Solutions, Llc | Expression vectors |
US7419829B2 (en) | 2000-10-06 | 2008-09-02 | Oxford Biomedica (Uk) Limited | Vector system |
GB0024550D0 (en) * | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
US20040038304A1 (en) | 2002-03-28 | 2004-02-26 | Gala Design, Inc. | Antibody libraries |
PT1534819E (en) | 2002-08-21 | 2010-03-11 | Revivicor Inc | Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase |
CA2548080A1 (en) | 2003-11-05 | 2005-05-26 | University Of Pittsburgh | Porcine isogloboside 3 synthase protein, cdna, genomic organization, and regulatory region |
CA2559720A1 (en) | 2004-03-17 | 2005-09-29 | Revivicor, Inc. | Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990001550A1 (en) * | 1988-07-29 | 1990-02-22 | Zymogenetics, Inc. | High efficiency translation of polycistronic messages in eucaryotic cells |
WO1993003143A1 (en) * | 1991-08-07 | 1993-02-18 | Anderson W French | Retroviral vectors containing internal ribosome entry sites |
EP0585983A2 (en) * | 1992-07-03 | 1994-03-09 | Q.B.I. Enterprises Limited | Nucleotide vector comprising a translation inhibition factor gene, and IRES region and a desired gene |
-
1994
- 1994-01-17 EP EP94909464A patent/EP0706319A4/en not_active Withdrawn
- 1994-01-17 JP JP6512538A patent/JPH08510636A/en active Pending
- 1994-01-17 AU AU62303/94A patent/AU6230394A/en not_active Abandoned
- 1994-01-17 WO PCT/US1994/000650 patent/WO1994024870A1/en not_active Application Discontinuation
- 1994-01-17 CA CA002162056A patent/CA2162056A1/en not_active Abandoned
- 1994-01-20 IL IL10838394A patent/IL108383A0/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990001550A1 (en) * | 1988-07-29 | 1990-02-22 | Zymogenetics, Inc. | High efficiency translation of polycistronic messages in eucaryotic cells |
WO1993003143A1 (en) * | 1991-08-07 | 1993-02-18 | Anderson W French | Retroviral vectors containing internal ribosome entry sites |
EP0585983A2 (en) * | 1992-07-03 | 1994-03-09 | Q.B.I. Enterprises Limited | Nucleotide vector comprising a translation inhibition factor gene, and IRES region and a desired gene |
Non-Patent Citations (1)
Title |
---|
See also references of WO9424870A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1994024870A1 (en) | 1994-11-10 |
EP0706319A1 (en) | 1996-04-17 |
CA2162056A1 (en) | 1994-11-10 |
AU6230394A (en) | 1994-11-21 |
IL108383A0 (en) | 1994-04-12 |
JPH08510636A (en) | 1996-11-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19951114 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): CH DE FR GB GR IE IT LI SE |
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RHK1 | Main classification (correction) |
Ipc: C12N 15/86 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19980306 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): CH DE FR GB GR IE IT LI SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 19980520 |