WO2004003170A3 - Agents capable of inhibiting ras and uses thereof - Google Patents

Agents capable of inhibiting ras and uses thereof Download PDF

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Publication number
WO2004003170A3
WO2004003170A3 PCT/US2003/020684 US0320684W WO2004003170A3 WO 2004003170 A3 WO2004003170 A3 WO 2004003170A3 US 0320684 W US0320684 W US 0320684W WO 2004003170 A3 WO2004003170 A3 WO 2004003170A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
eri1
agents capable
provides
inhibiting ras
Prior art date
Application number
PCT/US2003/020684
Other languages
French (fr)
Other versions
WO2004003170A2 (en
Inventor
David E Levin
Andrew K Sobering
Original Assignee
Univ Johns Hopkins
David E Levin
Andrew K Sobering
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, David E Levin, Andrew K Sobering filed Critical Univ Johns Hopkins
Priority to AU2003251751A priority Critical patent/AU2003251751A1/en
Publication of WO2004003170A2 publication Critical patent/WO2004003170A2/en
Publication of WO2004003170A3 publication Critical patent/WO2004003170A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention provides an agent capable of blocking the interaction between GTP-Ras and ERI1, wherein ERI1 is a protein comprising amino acids, the sequence of which amino acids is set forth in SEQ ID NO:7. In one embodiment, the agent comprises at least a portion of the ERI1 sequence. This invention provides a nucleic acid which encodes such agent. This invention also provides uses of the agent for treating cancer.
PCT/US2003/020684 2002-06-28 2003-06-30 Agents capable of inhibiting ras and uses thereof WO2004003170A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003251751A AU2003251751A1 (en) 2002-06-28 2003-06-30 Agents capable of inhibiting ras and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39235502P 2002-06-28 2002-06-28
US60/392,355 2002-06-28

Publications (2)

Publication Number Publication Date
WO2004003170A2 WO2004003170A2 (en) 2004-01-08
WO2004003170A3 true WO2004003170A3 (en) 2004-07-08

Family

ID=30000854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020684 WO2004003170A2 (en) 2002-06-28 2003-06-30 Agents capable of inhibiting ras and uses thereof

Country Status (2)

Country Link
AU (1) AU2003251751A1 (en)
WO (1) WO2004003170A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11235062B2 (en) * 2009-03-06 2022-02-01 Metaqor Llc Dynamic bio-nanoparticle elements
US9328142B2 (en) 2011-05-25 2016-05-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of RAS oncoproteins
CN118221770A (en) * 2017-07-10 2024-06-21 斯坦福国际研究院 Molecular targeting system peptides and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391580B1 (en) * 1996-12-12 2002-05-21 Incyte Genomics, Inc. Ras proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391580B1 (en) * 1996-12-12 2002-05-21 Incyte Genomics, Inc. Ras proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] March 2003 (2003-03-01), ROMEO ET AL: "Rin1, a novel ras inhibitor, engages yeast Ras at the endoplasmi reticulum", XP002977052, accession no. STN Database accession no. 2003:410882 *
FASEB J., vol. 17, no. 4-5 *
SOBERING ET AL: "A Novel Ras inhibitor, Eril, engages yeast ras at the endoplasmic reticulum", MOLECULAR & CELLULAR BIOLOGY, vol. 23, no. 14, 3 July 2003 (2003-07-03), pages 4983 - 4990, XP002977053 *

Also Published As

Publication number Publication date
AU2003251751A1 (en) 2004-01-19
AU2003251751A8 (en) 2004-01-19
WO2004003170A2 (en) 2004-01-08

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