JP2005503802A5 - - Google Patents
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- Publication number
- JP2005503802A5 JP2005503802A5 JP2003529974A JP2003529974A JP2005503802A5 JP 2005503802 A5 JP2005503802 A5 JP 2005503802A5 JP 2003529974 A JP2003529974 A JP 2003529974A JP 2003529974 A JP2003529974 A JP 2003529974A JP 2005503802 A5 JP2005503802 A5 JP 2005503802A5
- Authority
- JP
- Japan
- Prior art keywords
- template
- polynucleotide
- primer
- predetermined sequence
- oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims 55
- 102000040430 polynucleotide Human genes 0.000 claims 55
- 239000002157 polynucleotide Substances 0.000 claims 55
- 238000000034 method Methods 0.000 claims 32
- 108091034117 Oligonucleotide Proteins 0.000 claims 29
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 238000000137 annealing Methods 0.000 claims 17
- 230000000295 complement effect Effects 0.000 claims 16
- 108091008146 restriction endonucleases Proteins 0.000 claims 6
- 230000002194 synthesizing effect Effects 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 4
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32345501P | 2001-09-19 | 2001-09-19 | |
| PCT/US2002/029889 WO2003025202A2 (en) | 2001-09-19 | 2002-09-19 | Engineered templates and their use in single primer amplification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009016031A Division JP5107274B2 (ja) | 2001-09-19 | 2009-01-27 | 操作されたテンプレートおよび単一プライマー増幅におけるそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503802A JP2005503802A (ja) | 2005-02-10 |
| JP2005503802A5 true JP2005503802A5 (enExample) | 2006-01-05 |
| JP4439262B2 JP4439262B2 (ja) | 2010-03-24 |
Family
ID=23259271
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003529974A Expired - Fee Related JP4439262B2 (ja) | 2001-09-19 | 2002-09-19 | 操作されたテンプレートおよび単一プライマー増幅におけるそれらの使用 |
| JP2009016031A Expired - Fee Related JP5107274B2 (ja) | 2001-09-19 | 2009-01-27 | 操作されたテンプレートおよび単一プライマー増幅におけるそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009016031A Expired - Fee Related JP5107274B2 (ja) | 2001-09-19 | 2009-01-27 | 操作されたテンプレートおよび単一プライマー増幅におけるそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7306906B2 (enExample) |
| EP (1) | EP1436404B1 (enExample) |
| JP (2) | JP4439262B2 (enExample) |
| AT (1) | ATE448320T1 (enExample) |
| AU (1) | AU2002341752B2 (enExample) |
| CA (1) | CA2460639C (enExample) |
| CY (1) | CY1109828T1 (enExample) |
| DE (1) | DE60234369D1 (enExample) |
| DK (1) | DK1436404T3 (enExample) |
| ES (1) | ES2336433T3 (enExample) |
| PT (1) | PT1436404E (enExample) |
| WO (1) | WO2003025202A2 (enExample) |
Families Citing this family (76)
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| US7408041B2 (en) | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US20060057651A1 (en) | 2000-12-08 | 2006-03-16 | Bowdish Katherine S | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| WO2002048401A2 (en) | 2000-12-11 | 2002-06-20 | Alexion Pharmaceuticals, Inc. | Nested oligonucleotides containing hairpin for nucleic acid amplification |
| US7393656B2 (en) | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
| US7414111B2 (en) * | 2001-09-19 | 2008-08-19 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
| US7593483B2 (en) * | 2004-05-07 | 2009-09-22 | Broadcom Corporation | Nonlinear mapping in digital-to-analog and analog-to-digital converters |
| EP2290068A3 (en) * | 2004-05-28 | 2012-01-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
| US20060078894A1 (en) * | 2004-10-12 | 2006-04-13 | Winkler Matthew M | Methods and compositions for analyzing nucleic acids |
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| WO2007130967A2 (en) | 2006-05-01 | 2007-11-15 | Siemens Healthcare Diagnostics Inc. | Novel oligonucleotide primers and methods for dna replication |
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| CN101627121A (zh) * | 2006-12-08 | 2010-01-13 | 奥斯瑞根公司 | 作为治疗干预的靶标的miRNA调控基因和路径 |
| AU2007333106A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-20 regulated genes and pathways as targets for therapeutic intervention |
| CN101675165A (zh) * | 2006-12-08 | 2010-03-17 | 奥斯瑞根公司 | Let-7微小rna的功能和靶标 |
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| CN101801419A (zh) * | 2007-06-08 | 2010-08-11 | 米尔纳疗法公司 | 作为治疗干预的靶标的miR-34调控的基因和路径 |
| US8986684B2 (en) | 2007-07-25 | 2015-03-24 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating autoimmune disease |
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| US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| US20090192114A1 (en) * | 2007-12-21 | 2009-07-30 | Dmitriy Ovcharenko | miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
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| AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| US8748103B2 (en) * | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
| EP3699296A1 (en) | 2008-11-07 | 2020-08-26 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
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| WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
| AU2012325791B2 (en) | 2011-10-21 | 2018-04-05 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP2788509B1 (en) | 2011-12-09 | 2018-07-11 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| ES2662128T3 (es) | 2012-03-05 | 2018-04-05 | Adaptive Biotechnologies Corporation | Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes |
| PT2831276T (pt) | 2012-05-08 | 2016-07-26 | Adaptive Biotechnologies Corp | Composições e método para medição e calibração do viés de amplificação em reações pcr multiplex |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
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| EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP3715455A1 (en) | 2014-10-29 | 2020-09-30 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| US11066705B2 (en) | 2014-11-25 | 2021-07-20 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| US11041202B2 (en) | 2015-04-01 | 2021-06-22 | Adaptive Biotechnologies Corporation | Method of identifying human compatible T cell receptors specific for an antigenic target |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CN118356488A (zh) | 2017-05-30 | 2024-07-19 | 百时美施贵宝公司 | 包含抗lag-3抗体或抗lag-3抗体和抗pd-1或抗pd-l1抗体的组合物 |
| CN110720039A (zh) | 2017-05-30 | 2020-01-21 | 百时美施贵宝公司 | Lag-3阳性肿瘤的治疗 |
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| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
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-
2002
- 2002-09-19 EP EP02775901A patent/EP1436404B1/en not_active Expired - Lifetime
- 2002-09-19 WO PCT/US2002/029889 patent/WO2003025202A2/en not_active Ceased
- 2002-09-19 AU AU2002341752A patent/AU2002341752B2/en not_active Ceased
- 2002-09-19 DE DE60234369T patent/DE60234369D1/de not_active Expired - Lifetime
- 2002-09-19 PT PT02775901T patent/PT1436404E/pt unknown
- 2002-09-19 CA CA2460639A patent/CA2460639C/en not_active Expired - Fee Related
- 2002-09-19 ES ES02775901T patent/ES2336433T3/es not_active Expired - Lifetime
- 2002-09-19 US US10/251,085 patent/US7306906B2/en not_active Expired - Fee Related
- 2002-09-19 DK DK02775901.8T patent/DK1436404T3/da active
- 2002-09-19 AT AT02775901T patent/ATE448320T1/de active
- 2002-09-19 JP JP2003529974A patent/JP4439262B2/ja not_active Expired - Fee Related
-
2009
- 2009-01-27 JP JP2009016031A patent/JP5107274B2/ja not_active Expired - Fee Related
-
2010
- 2010-01-18 CY CY20101100051T patent/CY1109828T1/el unknown
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