JP2004536162A5 - - Google Patents
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- JP2004536162A5 JP2004536162A5 JP2002574322A JP2002574322A JP2004536162A5 JP 2004536162 A5 JP2004536162 A5 JP 2004536162A5 JP 2002574322 A JP2002574322 A JP 2002574322A JP 2002574322 A JP2002574322 A JP 2002574322A JP 2004536162 A5 JP2004536162 A5 JP 2004536162A5
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- Prior art keywords
- template
- oligonucleotide
- reactive unit
- reactive
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 94
- 108091034117 Oligonucleotide Proteins 0.000 claims 45
- 108020004705 Codon Proteins 0.000 claims 29
- 239000007795 chemical reaction product Substances 0.000 claims 29
- 108020005098 Anticodon Proteins 0.000 claims 16
- 108020004566 Transfer RNA Proteins 0.000 claims 16
- 238000000137 annealing Methods 0.000 claims 10
- 230000001939 inductive effect Effects 0.000 claims 8
- 230000000295 complement effect Effects 0.000 claims 7
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 230000009257 reactivity Effects 0.000 claims 4
- 238000003786 synthesis reaction Methods 0.000 claims 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 3
- 238000006664 bond formation reaction Methods 0.000 claims 2
- 239000000376 reactant Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27708101P | 2001-03-19 | 2001-03-19 | |
| US27709401P | 2001-03-19 | 2001-03-19 | |
| US30669101P | 2001-07-20 | 2001-07-20 | |
| PCT/US2002/008546 WO2002074929A2 (en) | 2001-03-19 | 2002-03-19 | Evolving new molecular function |
| US10/101,030 US7070928B2 (en) | 2001-03-19 | 2002-03-19 | Evolving new molecular function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008042250A Division JP4384229B2 (ja) | 2001-03-19 | 2008-02-22 | 新規分子機能の進化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536162A JP2004536162A (ja) | 2004-12-02 |
| JP2004536162A5 true JP2004536162A5 (enExample) | 2006-01-12 |
| JP4128453B2 JP4128453B2 (ja) | 2008-07-30 |
Family
ID=27493169
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002574322A Expired - Fee Related JP4128453B2 (ja) | 2001-03-19 | 2002-03-19 | 新規分子機能の進化 |
| JP2008042250A Expired - Fee Related JP4384229B2 (ja) | 2001-03-19 | 2008-02-22 | 新規分子機能の進化 |
| JP2009169425A Withdrawn JP2009232869A (ja) | 2001-03-19 | 2009-07-17 | 新規分子機能の進化 |
| JP2012165977A Expired - Fee Related JP5509270B2 (ja) | 2001-03-19 | 2012-07-26 | 新規分子機能の進化 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008042250A Expired - Fee Related JP4384229B2 (ja) | 2001-03-19 | 2008-02-22 | 新規分子機能の進化 |
| JP2009169425A Withdrawn JP2009232869A (ja) | 2001-03-19 | 2009-07-17 | 新規分子機能の進化 |
| JP2012165977A Expired - Fee Related JP5509270B2 (ja) | 2001-03-19 | 2012-07-26 | 新規分子機能の進化 |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US7070928B2 (enExample) |
| EP (3) | EP2332896A3 (enExample) |
| JP (4) | JP4128453B2 (enExample) |
| AT (1) | ATE335754T1 (enExample) |
| AU (2) | AU2002306777C1 (enExample) |
| CA (1) | CA2441820C (enExample) |
| DE (1) | DE60213826T3 (enExample) |
| DK (1) | DK1423400T4 (enExample) |
| ES (1) | ES2271306T5 (enExample) |
| IL (4) | IL158000A0 (enExample) |
| PT (1) | PT1423400E (enExample) |
| WO (1) | WO2002074929A2 (enExample) |
Families Citing this family (129)
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