JP2005518215A5 - - Google Patents
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- JP2005518215A5 JP2005518215A5 JP2003571485A JP2003571485A JP2005518215A5 JP 2005518215 A5 JP2005518215 A5 JP 2005518215A5 JP 2003571485 A JP2003571485 A JP 2003571485A JP 2003571485 A JP2003571485 A JP 2003571485A JP 2005518215 A5 JP2005518215 A5 JP 2005518215A5
- Authority
- JP
- Japan
- Prior art keywords
- primer
- strand
- nucleic acid
- coli
- rpa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 99
- 150000007523 nucleic acids Chemical class 0.000 claims 28
- 108020004707 nucleic acids Proteins 0.000 claims 26
- 102000039446 nucleic acids Human genes 0.000 claims 26
- 241000588724 Escherichia coli Species 0.000 claims 21
- 102000011931 Nucleoproteins Human genes 0.000 claims 16
- 108010061100 Nucleoproteins Proteins 0.000 claims 16
- 230000000295 complement effect Effects 0.000 claims 10
- 230000003321 amplification Effects 0.000 claims 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims 9
- 239000007850 fluorescent dye Substances 0.000 claims 8
- 102000016559 DNA Primase Human genes 0.000 claims 6
- 108010092681 DNA Primase Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 108700020796 Oncogene Proteins 0.000 claims 6
- 108010091086 Recombinases Proteins 0.000 claims 6
- 102000018120 Recombinases Human genes 0.000 claims 6
- 102000001218 Rec A Recombinases Human genes 0.000 claims 5
- 108010055016 Rec A Recombinases Proteins 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 108010025076 Holoenzymes Proteins 0.000 claims 4
- 108060004795 Methyltransferase Proteins 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 229940125532 enzyme inhibitor Drugs 0.000 claims 4
- 239000002532 enzyme inhibitor Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 102000007528 DNA Polymerase III Human genes 0.000 claims 3
- 108010071146 DNA Polymerase III Proteins 0.000 claims 3
- 241000549435 Pria Species 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 239000000539 dimer Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108050006400 Cyclin Proteins 0.000 claims 2
- 108010017826 DNA Polymerase I Proteins 0.000 claims 2
- 102000004594 DNA Polymerase I Human genes 0.000 claims 2
- 230000004544 DNA amplification Effects 0.000 claims 2
- 230000006820 DNA synthesis Effects 0.000 claims 2
- 101000990000 Enterobacteria phage T4 Sliding clamp Proteins 0.000 claims 2
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 2
- 102100036691 Proliferating cell nuclear antigen Human genes 0.000 claims 2
- 230000027455 binding Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000016361 genetic disease Diseases 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- OAKPWEUQDVLTCN-NKWVEPMBSA-N 2',3'-Dideoxyadenosine-5-triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO[P@@](O)(=O)O[P@](O)(=O)OP(O)(O)=O)O1 OAKPWEUQDVLTCN-NKWVEPMBSA-N 0.000 claims 1
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims 1
- 101710117642 Beta sliding clamp Proteins 0.000 claims 1
- 101000909256 Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) DNA polymerase I Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 102000012410 DNA Ligases Human genes 0.000 claims 1
- 108010061982 DNA Ligases Proteins 0.000 claims 1
- 101710177611 DNA polymerase II large subunit Proteins 0.000 claims 1
- 101710184669 DNA polymerase II small subunit Proteins 0.000 claims 1
- 101710159156 DNA polymerase IV Proteins 0.000 claims 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims 1
- 101710116602 DNA-Binding protein G5P Proteins 0.000 claims 1
- 108010006296 DnaB Helicases Proteins 0.000 claims 1
- 101100300807 Drosophila melanogaster spn-A gene Proteins 0.000 claims 1
- 108010014594 Heterogeneous Nuclear Ribonucleoprotein A1 Proteins 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 101000902592 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) DNA polymerase Proteins 0.000 claims 1
- 108091028733 RNTP Proteins 0.000 claims 1
- 101710162453 Replication factor A Proteins 0.000 claims 1
- 101710176758 Replication protein A 70 kDa DNA-binding subunit Proteins 0.000 claims 1
- 101710176276 SSB protein Proteins 0.000 claims 1
- 101710126859 Single-stranded DNA-binding protein Proteins 0.000 claims 1
- 101710142606 Sliding clamp Proteins 0.000 claims 1
- 101100117496 Sulfurisphaera ohwakuensis pol-alpha gene Proteins 0.000 claims 1
- NLTUCYMLOPLUHL-KQYNXXCUSA-N adenosine 5'-[gamma-thio]triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O NLTUCYMLOPLUHL-KQYNXXCUSA-N 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 claims 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35856302P | 2002-02-21 | 2002-02-21 | |
| PCT/US2003/005492 WO2003072805A2 (en) | 2002-02-21 | 2003-02-21 | Recombinase polymerase amplification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009026788A Division JP4448188B2 (ja) | 2002-02-21 | 2009-02-06 | リコンビナーゼポリメラーゼ増幅 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005518215A JP2005518215A (ja) | 2005-06-23 |
| JP2005518215A5 true JP2005518215A5 (enExample) | 2008-03-27 |
| JP4340543B2 JP4340543B2 (ja) | 2009-10-07 |
Family
ID=27765964
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571485A Expired - Lifetime JP4340543B2 (ja) | 2002-02-21 | 2003-02-21 | リコンビナーゼポリメラーゼ増幅 |
| JP2009026788A Expired - Lifetime JP4448188B2 (ja) | 2002-02-21 | 2009-02-06 | リコンビナーゼポリメラーゼ増幅 |
| JP2009278020A Expired - Lifetime JP5271244B2 (ja) | 2002-02-21 | 2009-12-07 | リコンビナーゼポリメラーゼ増幅 |
| JP2012203178A Withdrawn JP2012249637A (ja) | 2002-02-21 | 2012-09-14 | リコンビナーゼポリメラーゼ増幅 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009026788A Expired - Lifetime JP4448188B2 (ja) | 2002-02-21 | 2009-02-06 | リコンビナーゼポリメラーゼ増幅 |
| JP2009278020A Expired - Lifetime JP5271244B2 (ja) | 2002-02-21 | 2009-12-07 | リコンビナーゼポリメラーゼ増幅 |
| JP2012203178A Withdrawn JP2012249637A (ja) | 2002-02-21 | 2012-09-14 | リコンビナーゼポリメラーゼ増幅 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US7270981B2 (enExample) |
| EP (4) | EP2428588B1 (enExample) |
| JP (4) | JP4340543B2 (enExample) |
| AT (1) | ATE400663T1 (enExample) |
| AU (1) | AU2003215391B2 (enExample) |
| CA (1) | CA2476481C (enExample) |
| DE (1) | DE60322044D1 (enExample) |
| DK (1) | DK1499738T3 (enExample) |
| ES (1) | ES2310237T3 (enExample) |
| PT (1) | PT1499738E (enExample) |
| WO (1) | WO2003072805A2 (enExample) |
Families Citing this family (176)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6929915B2 (en) | 2001-04-20 | 2005-08-16 | The Penn State Research Foundation | Methods for nucleic acid manipulation |
| WO2005118853A2 (en) * | 2004-06-01 | 2005-12-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| DK1499738T3 (da) * | 2002-02-21 | 2008-11-17 | Asm Scient Inc | Recombinase-polymerease-amplifikation |
| AU2003272438B2 (en) * | 2002-09-20 | 2009-04-02 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| WO2004092330A2 (en) * | 2003-04-11 | 2004-10-28 | Applera Corporation | Method of generating long nucleic acid molecules of defined sequence |
| JP2005110621A (ja) * | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| AU2011202896B2 (en) * | 2004-06-01 | 2012-12-06 | Abbott Diagnostics Scarborough, Inc. | Recombinase Polymerase Amplification |
| WO2005118608A2 (en) | 2004-06-02 | 2005-12-15 | Asm Scientific, Inc. | 2’-nitrobenzyl-modified ribonucleotides |
| JP4534138B2 (ja) * | 2004-12-21 | 2010-09-01 | アイシン精機株式会社 | 核酸増幅反応における高度好熱菌由来タンパク質の活性化方法およびその利用 |
| US7579153B2 (en) * | 2005-01-25 | 2009-08-25 | Population Genetics Technologies, Ltd. | Isothermal DNA amplification |
| EP2829615B1 (en) | 2005-07-25 | 2018-05-09 | Alere San Diego, Inc. | Kit for multiplexing recombinase polymerase amplification |
| US7368265B2 (en) * | 2006-01-23 | 2008-05-06 | Compass Genetics, Llc | Selective genome amplification |
| EP2029782B1 (en) * | 2006-05-04 | 2014-11-26 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| AU2007338862B2 (en) | 2006-07-19 | 2014-02-06 | Bionano Genomics, Inc. | Nanonozzle device arrays: their preparation and use for macromolecular analysis |
| KR101522741B1 (ko) | 2007-03-28 | 2015-05-26 | 바이오나노 제노믹스, 인크. | 나노채널 어레이를 사용하는 거대분자 분석 방법 |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| US20090215050A1 (en) | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| US8628919B2 (en) | 2008-06-30 | 2014-01-14 | Bionano Genomics, Inc. | Methods and devices for single-molecule whole genome analysis |
| US8198028B2 (en) | 2008-07-02 | 2012-06-12 | Illumina Cambridge Limited | Using populations of beads for the fabrication of arrays on surfaces |
| WO2010059731A2 (en) | 2008-11-18 | 2010-05-27 | Bionanomatrix, Inc. | Polynucleotide mapping and sequencing |
| SG172965A1 (en) | 2009-01-13 | 2011-08-29 | Fluidigm Corp | Single-cell nucleic acid analysis |
| US8685648B2 (en) | 2009-02-03 | 2014-04-01 | Biohelix Corporation | Endonuclease-enhanced helicase-dependent amplification |
| US9309566B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
| US20120156728A1 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
| US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
| US9334531B2 (en) | 2010-12-17 | 2016-05-10 | Life Technologies Corporation | Nucleic acid amplification |
| US20100299773A1 (en) * | 2009-05-20 | 2010-11-25 | Monsanto Technology Llc | Methods and compositions for selecting an improved plant |
| JP5847076B2 (ja) | 2009-05-20 | 2016-01-20 | バイオサイト インコーポレイテッド | Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質 |
| WO2010141940A1 (en) * | 2009-06-05 | 2010-12-09 | Alere San Diego, Inc. | Recombinase polymerase amplification reagents and kits |
| WO2010147804A1 (en) * | 2009-06-10 | 2010-12-23 | Wisconsin Alumni Research Foundation | Method for dna double-strand break repair in vitro and applications thereof |
| NO329699B1 (no) * | 2009-06-16 | 2010-12-06 | Agr Cannseal As | Brønnverktøy og fremgangsmåte for in situ innføring av et behandlingsfluid i et ringrom i en brønn |
| WO2011047223A1 (en) | 2009-10-16 | 2011-04-21 | Monsanto Technology Llc | Methods of polynucleotide detection |
| GB0922097D0 (en) | 2009-12-17 | 2010-02-03 | Atlas Genetics Ltd | Microbial assay |
| WO2011106368A2 (en) | 2010-02-23 | 2011-09-01 | Illumina, Inc. | Amplification methods to minimise sequence specific bias |
| US9184099B2 (en) | 2010-10-04 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biosensor devices, systems and methods therefor |
| EP2625526B1 (en) | 2010-10-04 | 2017-03-15 | Genapsys Inc. | Systems and methods for automated reusable parallel biological reactions |
| US9399217B2 (en) | 2010-10-04 | 2016-07-26 | Genapsys, Inc. | Chamber free nanoreactor system |
| CA2814532C (en) | 2010-10-12 | 2021-07-27 | Monsanto Technology Llc | Soybean plant and seed corresponding to transgenic event mon87712 and methods for detection thereof |
| BR122021012776B1 (pt) | 2010-12-17 | 2022-08-16 | Monsanto Technology Llc | Método para melhorar a competência de uma célula de planta para transformação mediada por bactérias |
| EP3978620A1 (en) | 2011-04-07 | 2022-04-06 | Abbott Diagnostics Scarborough, Inc. | Monitoring recombinase polymerase amplification mixtures |
| US10172305B2 (en) | 2011-04-29 | 2019-01-08 | Monsanto Technology Llc | Diagnostic molecular markers for seed lot purity traits in soybeans |
| CA2834679C (en) | 2011-05-02 | 2021-12-28 | Board Of Regents Of The University Of Nebraska | Method for producing a plant with useful traits by suppressing msh1 gene |
| KR101940833B1 (ko) | 2011-05-27 | 2019-01-21 | 제납시스 인크. | 유전자 및 생물학적 분석을 위한 시스템 및 방법 |
| US8585973B2 (en) | 2011-05-27 | 2013-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Nano-sensor array |
| US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
| US9701976B2 (en) | 2011-06-30 | 2017-07-11 | Monsanto Technology Llc | Alfalfa plant and seed corresponding to transgenic event KK 179-2 and methods for detection thereof |
| US9670540B2 (en) | 2011-07-21 | 2017-06-06 | Cornell University | Methods and devices for DNA sequencing and molecular diagnostics |
| HUE059863T2 (hu) | 2011-08-31 | 2023-01-28 | Seminis Vegetable Seeds Inc | Eljárás és készítmények görögdinnye keménységhez |
| US9352312B2 (en) | 2011-09-23 | 2016-05-31 | Alere Switzerland Gmbh | System and apparatus for reactions |
| CN104105797B (zh) | 2011-12-01 | 2016-08-31 | 吉纳普赛斯股份有限公司 | 用于高效电子测序与检测的系统和方法 |
| JP5958034B2 (ja) * | 2012-04-11 | 2016-07-27 | 富士レビオ株式会社 | 分子ビーコン型プローブを用いた標的核酸の検出方法 |
| SG10201802883UA (en) | 2012-04-19 | 2018-05-30 | Life Technologies Corp | Nucleic acid amplification |
| EP3095879B1 (en) | 2012-04-19 | 2018-09-19 | Life Technologies Corporation | Nucleic acid amplification |
| CA3096342C (en) | 2012-06-08 | 2023-04-04 | Ionian Technologies, Llc | Nucleic acid amplifications |
| DE102012014981B3 (de) * | 2012-07-26 | 2013-07-18 | Sartorius Stedim Biotech Gmbh | Verfahren zur Differenzierung zwischen lebenden und toten Zellen |
| JP2015526092A (ja) | 2012-08-24 | 2015-09-10 | ライフ テクノロジーズ コーポレーション | 核酸ペアエンド配列決定のための方法、組成物、システム、装置、およびキット |
| WO2014043143A1 (en) | 2012-09-11 | 2014-03-20 | Life Technologies Corporation | Nucleic acid amplification |
| EP3257952B1 (en) | 2012-09-11 | 2020-02-12 | Life Technologies Corporation | Nucleic acid amplification |
| US10314253B2 (en) | 2012-12-04 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and compositions for watermelon sex expression |
| EP2971141B1 (en) | 2013-03-15 | 2018-11-28 | Genapsys, Inc. | Systems for biological analysis |
| SG11201507261WA (en) | 2013-03-15 | 2015-10-29 | Theranos Inc | Nucleic acid amplification |
| US10450595B2 (en) | 2013-03-15 | 2019-10-22 | Theranos Ip Company, Llc | Nucleic acid amplification |
| WO2014145296A2 (en) | 2013-03-15 | 2014-09-18 | Theranos, Inc. | Nuclei acid amplification |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| AU2014233145A1 (en) | 2013-03-15 | 2015-09-17 | Theranos Ip Company, Llc | Nucleic acid amplification |
| US10294489B2 (en) | 2013-03-15 | 2019-05-21 | Board Of Trustees Of Southern Illinois University | Soybean resistant to cyst nematodes |
| US10059999B2 (en) | 2013-06-10 | 2018-08-28 | Monsanto Technology Llc | Molecular markers associated with soybean tolerance to low iron growth conditions |
| US20150132743A1 (en) | 2013-09-04 | 2015-05-14 | Fluidigm Corporation | Proximity assays for detecting nucleic acids and proteins in a single cell |
| CN103421777B (zh) * | 2013-09-11 | 2015-05-13 | 北京市农林科学院林业果树研究所 | 无需pcr仪的侧翼核酸序列快速准确扩增方法及应用 |
| US10767188B2 (en) | 2013-09-25 | 2020-09-08 | Nutech Ventures | Methods and compositions for obtaining useful plant traits |
| NZ630628A (en) | 2013-10-08 | 2015-04-24 | Seminis Vegetable Seeds Inc | Methods and compositions for peronospora resistance in spinach |
| WO2015053998A1 (en) | 2013-10-09 | 2015-04-16 | Monsanto Technology Llc | Transgenic corn event mon87403 and methods for detection thereof |
| CN105722977A (zh) | 2013-10-30 | 2016-06-29 | 绿色生活生物技术有限责任公司 | 用于柑橘绿化枯萎病的发病定量系统和治疗方法 |
| NZ718164A (en) | 2013-11-27 | 2017-04-28 | Seminis Vegetable Seeds Inc | Disease resistance loci in onion |
| EP3080300B1 (en) | 2013-12-11 | 2020-09-02 | Genapsys Inc. | Systems and methods for biological analysis and computation |
| WO2015113725A1 (en) | 2014-02-03 | 2015-08-06 | Thermo Fisher Scientific Baltics Uab | Method for controlled dna fragmentation |
| EP3107373A4 (en) | 2014-02-21 | 2017-11-08 | Syngenta Participations AG | Genetic loci associated with increased fertility in maize |
| NZ630710A (en) | 2014-02-27 | 2016-03-31 | Seminis Vegetable Seeds Inc | Compositions and methods for peronospora resistance in spinach |
| EP3132060B1 (en) | 2014-04-18 | 2019-03-13 | Genapsys Inc. | Methods and systems for nucleic acid amplification |
| GB201410022D0 (en) * | 2014-06-05 | 2014-07-16 | Orion Diagnostica Oy | Method |
| EP3155127B1 (en) | 2014-06-13 | 2020-07-22 | Life Technologies Corporation | Multiplex nucleic acid amplification |
| US10316369B2 (en) | 2014-06-27 | 2019-06-11 | Seminis Vegetable Seeds, Inc. | Methods and assays for male sterile watermelon |
| WO2016011280A1 (en) | 2014-07-16 | 2016-01-21 | Tangen Biosciences, Inc. | Isothermal methods for amplifying nucleic acid samples |
| JP2017529093A (ja) | 2014-09-29 | 2017-10-05 | イルミナ ケンブリッジ リミテッド | リコンビナーゼ変異体 |
| EP3005862A1 (en) | 2014-10-10 | 2016-04-13 | Seminis Vegetable Seeds, Inc. | Melon plants with improved disease tolerance |
| US11559801B2 (en) | 2014-11-03 | 2023-01-24 | Tangen Biosciences, Inc. | Apparatus and method for cell, spore, or virus capture and disruption |
| WO2016176286A1 (en) | 2015-04-28 | 2016-11-03 | Monsanto Technology Llc | Methods and compositions for producing brachytic corn plants |
| US10415101B2 (en) | 2015-04-30 | 2019-09-17 | Monsanto Technology Llc | Methods for producing canola plants with clubroot resistance and compositions thereof |
| ES2759477T3 (es) | 2015-05-29 | 2020-05-11 | Hoffmann La Roche | Un procedimiento de inactivación de microbios por anhídrido citracónico |
| WO2016201142A1 (en) | 2015-06-09 | 2016-12-15 | Life Technologies Corporation | Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging |
| CR20180164A (es) | 2015-08-18 | 2018-09-04 | Monsanto Technology Llc | Métodos para producir plantas de algodón con tolerancia mejorada a la sequía y composiciones de estas |
| US10448595B2 (en) | 2015-09-03 | 2019-10-22 | Seminis Vegetable Seeds, Inc. | Downy mildew resistant lettuce plants |
| WO2017044744A2 (en) | 2015-09-10 | 2017-03-16 | Monsanto Technology Llc | Methods for producing corn plants with downy mildew resistance and compositions thereof |
| GB201519565D0 (en) | 2015-11-05 | 2015-12-23 | Alere San Diego Inc | Sample preparation device |
| EP3368654B1 (en) | 2015-10-30 | 2025-11-19 | Abbott Diagnostics Scarborough, Inc. | Determination of polymorphisms using isothermal nucleic acid amplification |
| HK1258716A1 (zh) | 2015-12-09 | 2019-11-15 | Life Technologies Corporation | 与表面结合的核酸分子的检测和量化 |
| CA3006080A1 (en) | 2015-12-18 | 2017-06-22 | Monsanto Technology Llc | Methods for producing corn plants with northern leaf blight resistance and compositions thereof |
| US10329601B2 (en) | 2015-12-28 | 2019-06-25 | Ionian Technologies, Inc. | Nicking and extension amplification reaction (NEAR) of Streptococcus species |
| LT3402880T (lt) | 2016-01-15 | 2024-03-12 | Thermo Fisher Scientific Baltics Uab | Termofiliniai dnr polimerazės mutantai |
| ES3032616T3 (en) | 2016-02-26 | 2025-07-22 | Abbott Diagnostics Scarborough Inc | Redox labeled oligonucleotide probes and their use |
| KR20220167397A (ko) | 2016-03-04 | 2022-12-20 | 애보트 다이어그노스틱스 스카보로, 인크. | 자동화된 네스티드 재조합효소 중합효소 증폭 |
| WO2017172699A1 (en) | 2016-03-28 | 2017-10-05 | Illumina, Inc. | Recombinase mutants |
| US11299777B2 (en) | 2016-04-04 | 2022-04-12 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| US9617587B1 (en) | 2016-04-04 | 2017-04-11 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| EP3469078B1 (en) | 2016-06-10 | 2024-03-27 | Life Technologies Corporation | Methods and compositions for nucleic acid amplification |
| EP3488017A4 (en) | 2016-07-20 | 2020-02-26 | Genapsys Inc. | SYSTEMS AND METHODS FOR SEQUENCING NUCLEIC ACIDS |
| WO2018031874A1 (en) | 2016-08-11 | 2018-02-15 | Monsanto Technology Llc | Methods and compositions for producing corn plants with resistance to late wilt |
| EP4417691A3 (en) | 2016-09-15 | 2024-11-13 | Abbott Laboratories | Devices and methods for sample analysis |
| AU2017232187B2 (en) | 2016-09-30 | 2023-11-09 | Seminis Vegetable Seeds, Inc. | Xanthomonas resistant brassica oleracea plants |
| WO2018071522A1 (en) | 2016-10-11 | 2018-04-19 | Life Technologies Corporation | Rapid amplification of nucleic acids |
| CN106701738B (zh) * | 2016-11-10 | 2020-05-08 | 中国科学院成都生物研究所 | 一种等温解开双链dna及制备单链dna的方法 |
| US10632464B2 (en) | 2017-02-28 | 2020-04-28 | Alere San Diego, Inc. | Microfluidic devices and related methods |
| US11542540B2 (en) | 2017-06-16 | 2023-01-03 | Life Technologies Corporation | Control nucleic acids, and compositions, kits, and uses thereof |
| US11618891B2 (en) | 2017-06-26 | 2023-04-04 | Thermo Fisher Scientific Baltics Uab | Thermophilic DNA polymerase mutants |
| EP3676394A4 (en) | 2017-08-31 | 2021-06-02 | Ionian Technologies, LLC | SYNCYTIAL SYNCHRONIZATION AND EXTENSION AMPLIFICATION REACTION (NEAR) OF RESPIRATORY VIRUS SPECIES |
| KR102800957B1 (ko) | 2017-09-14 | 2025-04-30 | 애보트 다이어그노스틱스 스카보로, 인크. | 이중-합텐 프로브를 이용한 재조합효소 폴리머라제 증폭의 검출 |
| EP3684951A4 (en) | 2017-09-21 | 2021-06-16 | Genapsys, Inc. | NUCLEIC ACID SEQUENCING SYSTEMS AND METHODS |
| US12226745B2 (en) | 2017-11-07 | 2025-02-18 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| WO2019094524A1 (en) | 2017-11-07 | 2019-05-16 | Life Technologies Corporation | Methods and compositions for manipulating nucleic acids |
| CN108034763B (zh) * | 2017-12-21 | 2021-10-22 | 北京卓诚惠生生物科技股份有限公司 | 检测甲型肝炎和戊型肝炎病毒的引物、探针及试剂盒 |
| US10101328B1 (en) | 2017-12-29 | 2018-10-16 | Clear Labs, Inc. | Detection of microorganisms in food samples and food processing facilities |
| EP3731959B1 (en) | 2017-12-29 | 2025-10-08 | Clear Labs, Inc. | Automated priming and library loading device |
| US11268102B2 (en) | 2018-05-16 | 2022-03-08 | University Of Florida Research Foundation, Incorporated | Compositions and methods for identifying and selecting brachytic locus in solanaceae |
| AU2019287163B2 (en) | 2018-06-12 | 2025-08-21 | Keygene N.V. | Nucleic acid amplification method |
| CN108410954A (zh) * | 2018-07-10 | 2018-08-17 | 默禾医疗科技（上海）有限公司 | 一种室温扩增反应体系中反应缓冲液的制配方法 |
| WO2020018824A1 (en) | 2018-07-19 | 2020-01-23 | Ultima Genomics, Inc. | Nucleic acid clonal amplification and sequencing methods, systems, and kits |
| US20210388431A1 (en) * | 2018-10-29 | 2021-12-16 | Igor V. Kutyavin | Thermokinetically balanced isothermal amplification of nucleic acid sequences |
| EP3894598B1 (en) | 2018-12-14 | 2024-01-03 | Illumina Cambridge Limited | Decreasing phasing with unlabeled nucleotides during sequencing |
| WO2020126593A1 (en) | 2018-12-17 | 2020-06-25 | Illumina Cambridge Limited | Compositions for use in polyunucleotide sequencing |
| EP3899036A1 (en) | 2018-12-17 | 2021-10-27 | Illumina Cambridge Limited | Primer oligonucleotide for sequencing |
| CA3126761C (en) | 2019-01-15 | 2023-01-10 | Seminis Vegetable Seeds, Inc. | Green bean plants with improved disease resistance |
| CN113906148B (zh) | 2019-05-03 | 2024-12-31 | 生命技术公司 | 用于操纵核酸的方法和组合物 |
| WO2021011850A2 (en) * | 2019-07-17 | 2021-01-21 | Chao Chien Chung | Amplification assay for the detection of anaplasma phagocytophilum |
| CN114514328A (zh) | 2019-08-21 | 2022-05-17 | 生命技术公司 | 用于测序的系统和方法 |
| US11542513B2 (en) | 2019-09-26 | 2023-01-03 | Seminis Vegetable Seeds, Inc. | Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1 |
| GB201916379D0 (en) | 2019-11-11 | 2019-12-25 | Biocrucible Ltd | Biochemical reaction methods and reagents |
| WO2021226754A1 (zh) * | 2020-05-09 | 2021-11-18 | 杭州梓晶生物有限公司 | 一种病毒重组酶-聚合酶扩增检测方法 |
| WO2021228839A1 (en) | 2020-05-11 | 2021-11-18 | Deutsches Krebsforschungszentrum | Polynucleotide detection by cas nucleases |
| AU2021204717B2 (en) | 2020-07-15 | 2026-05-28 | Seminis Vegetable Seeds, Inc. | Green Bean Plants with Improved Disease Resistance |
| EP4243986A1 (en) | 2020-11-16 | 2023-09-20 | Life Technologies Corporation | System and method for sequencing |
| WO2022189819A1 (en) | 2021-03-09 | 2022-09-15 | Etablissement Francais Du Sang | Detection of infectious agent based on recombinase polymerase amplification combined with a magnetic field-enhanced agglutination |
| JP2024518331A (ja) | 2021-04-29 | 2024-05-01 | アボット・ラボラトリーズ | 生体試料のハイスループット核酸検査 |
| US12668836B2 (en) | 2021-05-21 | 2026-06-30 | Tetracore, Inc. | Detection of recombinase polymerase amplification (RPA) amplicons via FEN1 cleavage |
| WO2022266946A1 (zh) * | 2021-06-24 | 2022-12-29 | 黄婉秋 | 检测病原体rna、及动物或人类基因rna的试剂盒及其应用 |
| GB202110479D0 (en) | 2021-07-21 | 2021-09-01 | Dnae Diagnostics Ltd | Compositions, kits and methods for sequencing target polynucleotides |
| US20250269368A1 (en) | 2021-07-21 | 2025-08-28 | Dnae Group Holdings Limited | Method and system comprising a cartridge for sequencing target polynucleotides |
| GB202110485D0 (en) | 2021-07-21 | 2021-09-01 | Dnae Diagnostics Ltd | Compositions, kits and methods for sequencing target polynucleotides |
| EP4381094B1 (en) | 2021-08-03 | 2025-07-02 | Wageningen Universiteit | Argonaute-based nucleic acid detection system |
| US12480157B2 (en) | 2021-09-30 | 2025-11-25 | Illumina, Inc. | Polynucleotide sequencing |
| CN114237548B (zh) * | 2021-11-22 | 2023-07-18 | 南京大学 | 基于非易失性存储器阵列的复数点乘运算的方法及系统 |
| CN113981045B (zh) | 2021-11-23 | 2025-09-16 | 广州达安基因股份有限公司 | 制备恒温扩增混合酶系的方法 |
| CN114085891A (zh) | 2021-11-23 | 2022-02-25 | 广州达安基因股份有限公司 | 基于重组酶聚合酶扩增技术的逆转录扩增系统和方法 |
| US20230193310A1 (en) | 2021-12-10 | 2023-06-22 | Seminis Vegetabe Seeds, Inc. | Lettuce plants having resistance to downy mildew |
| US20230404003A1 (en) | 2022-06-21 | 2023-12-21 | Seminis Vegetable Seeds, Inc. | Novel qtls conferring resistance to cucumber mosaic virus |
| EP4565720A1 (en) | 2022-08-04 | 2025-06-11 | Abbott Laboratories | Assays for detecting monkeypox virus |
| TWI909224B (zh) | 2022-09-29 | 2025-12-21 | 美商宜曼達股份有限公司 | 動態光學校準設備及動態校準光學系統組件之方法 |
| MX2024004405A (es) | 2023-04-14 | 2024-11-08 | Seminis Vegetable Seeds Inc | Métodos y composiciones de resistencia a peronospora en la espinaca |
| WO2025049450A1 (en) | 2023-08-28 | 2025-03-06 | Abbott Molecular, Inc. | Assays for detecting bk virus (bkv) |
| EP4771172A1 (en) | 2023-08-28 | 2026-07-08 | Abbott Molecular Inc. | Assays for detecting cytomegalovirus (cmv) or epstein-bar virus (ebv) |
| KR20260115973A (ko) | 2023-11-21 | 2026-07-27 | 애벗트 라보라토리이즈 | 2차원 매트릭스 액적 어레이 |
| WO2025144626A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Sequencing with single-stranded binding proteins |
| WO2025144744A1 (en) | 2023-12-29 | 2025-07-03 | Life Technologies Corporation | Enrichment of clonal substrates |
| WO2025188823A1 (en) | 2024-03-07 | 2025-09-12 | Illumina, Inc. | Immersion microscopy arrangement for sequencing system with rapid scanning |
| WO2025244815A1 (en) | 2024-05-21 | 2025-11-27 | Illumina, Inc. | Flow cell assemblies and related systems and methods |
| WO2026050593A2 (en) | 2024-08-30 | 2026-03-05 | Illumina, Inc. | Apparatus and method to mitigate thermally induced aberrations in immersion optical system |
| WO2026059922A1 (en) | 2024-09-10 | 2026-03-19 | Illumina, Inc. | Molecular deduplication analysis methods |
| WO2026059956A1 (en) | 2024-09-11 | 2026-03-19 | Seminis Vegetable Seeds, Inc. | Qtls conferring resistance to cucurbit aphid-borne yellow virus |
| WO2026073129A1 (en) | 2024-09-30 | 2026-04-02 | Illumina, Inc. | Targeted variant calling using target enrichment sequencing data |
| WO2026076044A1 (en) | 2024-10-03 | 2026-04-09 | Illumina, Inc. | Read-level methylation detection |
| WO2026096670A1 (en) | 2024-10-30 | 2026-05-07 | Illumina, Inc. | Precision, recall, and f-score for continuous distributions |
| WO2026102281A1 (en) | 2024-11-08 | 2026-05-15 | Illumina, Inc. | On-flow cell library preparation for single-cell rna analysis |
| WO2026148239A1 (en) | 2025-01-06 | 2026-07-09 | Illumina, Inc. | Association mapping on single-cell rna sequencing data |
| GB202500508D0 (en) | 2025-01-15 | 2025-02-26 | Biocrucible Ltd | Molecular diagnostic device |
| WO2026161559A1 (en) | 2025-01-22 | 2026-07-30 | Illumina, Inc. | Methylated region wide association studies |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US603585A (en) | 1898-05-03 | cbowell | ||
| US5430136A (en) | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5635347A (en) * | 1986-04-30 | 1997-06-03 | Igen, Inc. | Rapid assays for amplification products |
| US5858652A (en) * | 1988-08-30 | 1999-01-12 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
| GB8903627D0 (en) | 1989-02-17 | 1989-04-05 | Unilever Plc | Assays |
| KR950013953B1 (ko) * | 1990-01-26 | 1995-11-18 | 애보트 래보라토리즈 | 리가제 연쇄 반응에 적용가능한 표적 핵산의 증폭 방법 |
| US5326692B1 (en) | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
| KR100245284B1 (ko) * | 1990-05-07 | 2000-03-02 | 이노우에 노리유끼 | 이중 d-루프 형성의 진단학적 응용 |
| US5273881A (en) * | 1990-05-07 | 1993-12-28 | Daikin Industries, Ltd. | Diagnostic applications of double D-loop formation |
| US5223414A (en) | 1990-05-07 | 1993-06-29 | Sri International | Process for nucleic acid hybridization and amplification |
| EP0540693B1 (en) | 1990-07-24 | 1999-01-20 | F. Hoffmann-La Roche Ag | THE REDUCTION OF NON-SPECIFIC AMPLIFICATION DURING $i(IN VITRO) NUCLEIC ACID AMPLIFICATION USING MODIFIED NUCLEIC ACID BASES |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5556751A (en) | 1991-04-25 | 1996-09-17 | Amoco Corporation | Selective amplification system using Q-β replicase |
| EP0524349A1 (en) * | 1991-07-08 | 1993-01-27 | Opticon Sensors Europe B.V. | Dual-focus scanner and such a scanner used as wandtype symbol code reader |
| CA2077135A1 (en) * | 1991-08-30 | 1993-03-01 | Joh-E Ikeda | A method of dna amplification |
| US5614389A (en) | 1992-08-04 | 1997-03-25 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| US5733733A (en) | 1992-08-04 | 1998-03-31 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| US5834202A (en) | 1992-08-04 | 1998-11-10 | Replicon, Inc. | Methods for the isothermal amplification of nucleic acid molecules |
| WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| CA2122203C (en) | 1993-05-11 | 2001-12-18 | Melinda S. Fraiser | Decontamination of nucleic acid amplification reactions |
| FR2708288B1 (fr) * | 1993-07-26 | 1995-09-01 | Bio Merieux | Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé. |
| US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| US5705366A (en) | 1994-09-15 | 1998-01-06 | Johnson & Johnson Clinical Diagnostics, Inc. | Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor |
| US5656430A (en) | 1995-06-07 | 1997-08-12 | Trevigen, Inc. | Oscillating signal amplifier for nucleic acid detection |
| US5916779A (en) | 1995-09-21 | 1999-06-29 | Becton, Dickinson And Company | Strand displacement amplification of RNA targets |
| US5731150A (en) | 1995-11-01 | 1998-03-24 | Chiron Diagnostic Corporation | IS6110 based molecular detection of mycobacterium tuberculosis |
| WO1997046715A1 (en) * | 1996-06-03 | 1997-12-11 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Fc receptor polymorphism |
| US5853990A (en) * | 1996-07-26 | 1998-12-29 | Edward E. Winger | Real time homogeneous nucleotide assay |
| DE69730145T2 (de) * | 1996-08-29 | 2005-07-14 | Tapestry Pharmaceuticals, Inc., Boulder | VERFAHREN ZUM AUFFINDEN, NACHWEISEN, ANREICHERN UND/ODER ISOLIEREN VON ZIEL-NUcLEINSÄURESEQUENZEN UNTER VERWENDUNG VON VON RECA ÄHNLICHER REKOMBINASE |
| CA2256563A1 (en) | 1997-04-04 | 1998-10-15 | Innogenetics N.V. | Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions |
| US6245506B1 (en) | 1997-07-30 | 2001-06-12 | Bbi Bioseq, Inc. | Integrated sequencing device |
| DK1071811T3 (da) | 1998-04-22 | 2002-06-17 | Entpr Ie Trd As Bioresearch Ie | Fremgangsmåde til karakterisering af nukleinsyremolekyler, hvilken fremgangsmåde involverer generering af forlængelige opstrøms-DNA-fragmenter, som er et resultat af spaltningen af nukleinsyre i et abasisk sted |
| WO1999060158A1 (en) | 1998-05-19 | 1999-11-25 | Laboratory Of Molecular Biophotonics | Solid phase for detecting nucleic acid and method for detecting nucleic acid |
| US6140054A (en) * | 1998-09-30 | 2000-10-31 | University Of Utah Research Foundation | Multiplex genotyping using fluorescent hybridization probes |
| US6087112A (en) * | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
| JP2003526328A (ja) | 1999-01-11 | 2003-09-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Ｄｎａの等温増幅 |
| WO2000046408A1 (en) | 1999-02-04 | 2000-08-10 | Sloan-Kettering Institute For Cancer Research | Process for dna replication |
| US6699693B1 (en) * | 1999-02-04 | 2004-03-02 | Sloan-Kettering Institute For Cancer Research | Process for DNA replication |
| US6387621B1 (en) | 1999-04-27 | 2002-05-14 | University Of Utah Research Foundation | Automated analysis of real-time nucleic acid amplification |
| US6509157B1 (en) * | 1999-11-05 | 2003-01-21 | Roche Molecular Systems, Inc | 3 blocked nucleic acid amplification primers |
| NO314091B1 (no) * | 2000-01-12 | 2003-01-27 | Biotec Pharmacon Asa | Varmelabil uracil-DNA-glykosylase, DNA-sekvens som koder for enzymet, mikroorganisme som inneholder DNA-sekvensen, samt anvendelse av enzymet |
| US20010044111A1 (en) | 2000-03-20 | 2001-11-22 | Brian Carr | Method for generating recombinant DNA molecules in complex mixtures |
| EP1278889B1 (en) | 2000-03-29 | 2006-07-26 | LGC Limited | Hybridisation beacon and method of rapid sequence detection and discrimination |
| US20020061530A1 (en) | 2000-07-31 | 2002-05-23 | Belotserkovskii Boris P. | Enhanced targeting of DNA sequences by recombinase protein and single-stranded homologous DNA probes using DNA analog activation |
| IE20000887A1 (en) | 2000-11-03 | 2002-12-11 | Univ College Cork Nat Univ Ie | Method for the amplification and optional characterisation of nucleic acids |
| US6379899B1 (en) * | 2001-03-13 | 2002-04-30 | Discoverx | Isothermal exponential RNA amplification in complex mixtures |
| US6929915B2 (en) * | 2001-04-20 | 2005-08-16 | The Penn State Research Foundation | Methods for nucleic acid manipulation |
| EP1275735A1 (en) | 2001-07-11 | 2003-01-15 | Roche Diagnostics GmbH | Composition and method for hot start nucleic acid amplification |
| WO2003008624A2 (en) | 2001-07-15 | 2003-01-30 | Keck Graduate Institute | Nucleic acid amplification using nicking agents |
| EP1470250A2 (en) | 2001-07-15 | 2004-10-27 | Keck Graduate Institute | Gene expression analysis using nicking agents |
| US7056671B2 (en) | 2001-08-20 | 2006-06-06 | Takara Bio Inc. | Isothermal chimeric primer nucleic acid amplification methods using blocking oglionucleotide |
| EP1446502A4 (en) | 2001-09-28 | 2005-02-09 | Univ Delaware | DETECTION AND SEPARATION OF POLYMORPHISMS |
| KR100445560B1 (ko) | 2001-10-31 | 2004-08-21 | (주)바이오넥스 | 핵산 또는 생물학적 물질을 분리하기 위한 키트의 제조방법과, 그 방법에 의해 제조된 키트와, 그 키트를사용하는 장치 |
| US7244562B2 (en) * | 2001-11-01 | 2007-07-17 | Gene Check, Inc. | RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US8030000B2 (en) | 2002-02-21 | 2011-10-04 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| DK1499738T3 (da) | 2002-02-21 | 2008-11-17 | Asm Scient Inc | Recombinase-polymerease-amplifikation |
| WO2005118853A2 (en) * | 2004-06-01 | 2005-12-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US20040137456A1 (en) * | 2002-04-04 | 2004-07-15 | Hiroki Yokota | Method for identifying and characterizing individual dna molecules |
| US20030228611A1 (en) | 2002-05-01 | 2003-12-11 | President And Fellows Of Harvard College | Nucleic acid memory device |
| US6713262B2 (en) | 2002-06-25 | 2004-03-30 | Agilent Technologies, Inc. | Methods and compositions for high throughput identification of protein/nucleic acid binding pairs |
| EP1525055A1 (en) | 2002-07-12 | 2005-04-27 | British Biocell International Limited | Lateral flow assay device and method |
| US20040038213A1 (en) | 2002-08-06 | 2004-02-26 | Kwon Jai W. | Genotyping by in situ PCR amplification of a polynucleotide in a tissue biopsy |
| CA2494993A1 (en) | 2002-08-21 | 2004-03-04 | Epoch Biosciences, Inc. | Abasic site endonuclease assay |
| AU2003272438B2 (en) * | 2002-09-20 | 2009-04-02 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| US20040224336A1 (en) * | 2003-03-11 | 2004-11-11 | Gene Check, Inc. | RecA-assisted specific oligonucleotide extension method for detecting mutations, SNPs and specific sequences |
| DE10315640A1 (de) | 2003-04-04 | 2004-10-14 | Ignatov, Konstantin | Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung |
| JP2005110621A (ja) * | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| US20050191682A1 (en) | 2004-02-17 | 2005-09-01 | Affymetrix, Inc. | Methods for fragmenting DNA |
| US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| WO2006040187A2 (en) | 2004-10-11 | 2006-04-20 | Epigenomics Ag | A method for the carry-over protection in dna amplification systems targeting methylation analysis achieved by a modified pre-treatment of nucleic acids |
| CA2588865A1 (en) | 2004-11-23 | 2006-06-01 | Xiao Bing Wang | Detection of nucleic acid variation by cleavage-amplification method |
| WO2006119280A2 (en) | 2005-05-03 | 2006-11-09 | Handylab, Inc. | Lyophilized pellets |
| US20070042427A1 (en) | 2005-05-03 | 2007-02-22 | Micronics, Inc. | Microfluidic laminar flow detection strip |
| EP1883707B1 (en) | 2005-05-26 | 2014-04-09 | Human Genetic Signatures PTY Ltd | Isothermal strand displacement amplification using primers containing a non-regular base |
| WO2007008997A2 (en) | 2005-07-12 | 2007-01-18 | The Board Of Trustees Of The Leland Stanford Junior University | Template specific inhibition of pcr |
| EP2829615B1 (en) | 2005-07-25 | 2018-05-09 | Alere San Diego, Inc. | Kit for multiplexing recombinase polymerase amplification |
| EP2029782B1 (en) * | 2006-05-04 | 2014-11-26 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| CA2687375C (en) | 2007-05-18 | 2017-08-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Primers and probes for the detection of streptococcus pneumoniae |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| ES2320840B1 (es) | 2007-11-27 | 2010-07-01 | Nelson Alfonso Egued | Tubo humectador de doble camara. |
| JP2009139487A (ja) | 2007-12-04 | 2009-06-25 | Nippon Sheet Glass Co Ltd | 正立等倍レンズアレイプレート |
| JP5847076B2 (ja) | 2009-05-20 | 2016-01-20 | バイオサイト インコーポレイテッド | Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質 |
| WO2010141940A1 (en) | 2009-06-05 | 2010-12-09 | Alere San Diego, Inc. | Recombinase polymerase amplification reagents and kits |
| CA3096342C (en) | 2012-06-08 | 2023-04-04 | Ionian Technologies, Llc | Nucleic acid amplifications |
-
2003
- 2003-02-21 DK DK03711216T patent/DK1499738T3/da active
- 2003-02-21 ES ES03711216T patent/ES2310237T3/es not_active Expired - Lifetime
- 2003-02-21 EP EP11184367.8A patent/EP2428588B1/en not_active Expired - Lifetime
- 2003-02-21 AU AU2003215391A patent/AU2003215391B2/en not_active Expired
- 2003-02-21 JP JP2003571485A patent/JP4340543B2/ja not_active Expired - Lifetime
- 2003-02-21 PT PT03711216T patent/PT1499738E/pt unknown
- 2003-02-21 CA CA2476481A patent/CA2476481C/en not_active Expired - Lifetime
- 2003-02-21 EP EP10180775.8A patent/EP2290096B1/en not_active Expired - Lifetime
- 2003-02-21 EP EP08012222.9A patent/EP1992706B1/en not_active Expired - Lifetime
- 2003-02-21 WO PCT/US2003/005492 patent/WO2003072805A2/en not_active Ceased
- 2003-02-21 DE DE60322044T patent/DE60322044D1/de not_active Expired - Lifetime
- 2003-02-21 US US10/371,641 patent/US7270981B2/en not_active Expired - Lifetime
- 2003-02-21 EP EP03711216A patent/EP1499738B1/en not_active Expired - Lifetime
- 2003-02-21 AT AT03711216T patent/ATE400663T1/de active
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2007
- 2007-08-13 US US11/893,113 patent/US7485428B2/en not_active Expired - Lifetime
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2009
- 2009-01-30 US US12/322,354 patent/US20090325165A1/en not_active Abandoned
- 2009-02-06 JP JP2009026788A patent/JP4448188B2/ja not_active Expired - Lifetime
- 2009-12-07 JP JP2009278020A patent/JP5271244B2/ja not_active Expired - Lifetime
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2010
- 2010-04-30 US US12/799,786 patent/US20110065106A1/en not_active Abandoned
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2011
- 2011-07-28 US US13/192,806 patent/US8460875B2/en not_active Expired - Fee Related
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2012
- 2012-09-14 JP JP2012203178A patent/JP2012249637A/ja not_active Withdrawn
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2013
- 2013-06-06 US US13/911,268 patent/US9340825B2/en not_active Expired - Fee Related
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2016
- 2016-04-15 US US15/099,754 patent/US20170044598A1/en not_active Abandoned
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