JP2005518215A5 - - Google Patents
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- JP2005518215A5 JP2005518215A5 JP2003571485A JP2003571485A JP2005518215A5 JP 2005518215 A5 JP2005518215 A5 JP 2005518215A5 JP 2003571485 A JP2003571485 A JP 2003571485A JP 2003571485 A JP2003571485 A JP 2003571485A JP 2005518215 A5 JP2005518215 A5 JP 2005518215A5
- Authority
- JP
- Japan
- Prior art keywords
- primer
- strand
- nucleic acid
- coli
- rpa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 99
- 150000007523 nucleic acids Chemical class 0.000 claims 28
- 108020004707 nucleic acids Proteins 0.000 claims 26
- 102000039446 nucleic acids Human genes 0.000 claims 26
- 241000588724 Escherichia coli Species 0.000 claims 21
- 102000011931 Nucleoproteins Human genes 0.000 claims 16
- 108010061100 Nucleoproteins Proteins 0.000 claims 16
- 230000000295 complement effect Effects 0.000 claims 10
- 230000003321 amplification Effects 0.000 claims 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims 9
- 239000007850 fluorescent dye Substances 0.000 claims 8
- 102000016559 DNA Primase Human genes 0.000 claims 6
- 108010092681 DNA Primase Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 108700020796 Oncogene Proteins 0.000 claims 6
- 108010091086 Recombinases Proteins 0.000 claims 6
- 102000018120 Recombinases Human genes 0.000 claims 6
- 102000001218 Rec A Recombinases Human genes 0.000 claims 5
- 108010055016 Rec A Recombinases Proteins 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 108010025076 Holoenzymes Proteins 0.000 claims 4
- 108060004795 Methyltransferase Proteins 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 229940125532 enzyme inhibitor Drugs 0.000 claims 4
- 239000002532 enzyme inhibitor Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 102000007528 DNA Polymerase III Human genes 0.000 claims 3
- 108010071146 DNA Polymerase III Proteins 0.000 claims 3
- 241000549435 Pria Species 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 239000000539 dimer Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108050006400 Cyclin Proteins 0.000 claims 2
- 108010017826 DNA Polymerase I Proteins 0.000 claims 2
- 102000004594 DNA Polymerase I Human genes 0.000 claims 2
- 230000004544 DNA amplification Effects 0.000 claims 2
- 230000006820 DNA synthesis Effects 0.000 claims 2
- 101000990000 Enterobacteria phage T4 Sliding clamp Proteins 0.000 claims 2
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 2
- 102100036691 Proliferating cell nuclear antigen Human genes 0.000 claims 2
- 230000027455 binding Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000016361 genetic disease Diseases 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- OAKPWEUQDVLTCN-NKWVEPMBSA-N 2',3'-Dideoxyadenosine-5-triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO[P@@](O)(=O)O[P@](O)(=O)OP(O)(O)=O)O1 OAKPWEUQDVLTCN-NKWVEPMBSA-N 0.000 claims 1
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims 1
- 101710117642 Beta sliding clamp Proteins 0.000 claims 1
- 101000909256 Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) DNA polymerase I Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 102000012410 DNA Ligases Human genes 0.000 claims 1
- 108010061982 DNA Ligases Proteins 0.000 claims 1
- 101710177611 DNA polymerase II large subunit Proteins 0.000 claims 1
- 101710184669 DNA polymerase II small subunit Proteins 0.000 claims 1
- 101710159156 DNA polymerase IV Proteins 0.000 claims 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims 1
- 101710116602 DNA-Binding protein G5P Proteins 0.000 claims 1
- 108010006296 DnaB Helicases Proteins 0.000 claims 1
- 101100300807 Drosophila melanogaster spn-A gene Proteins 0.000 claims 1
- 108010014594 Heterogeneous Nuclear Ribonucleoprotein A1 Proteins 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 101000902592 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) DNA polymerase Proteins 0.000 claims 1
- 108091028733 RNTP Proteins 0.000 claims 1
- 101710162453 Replication factor A Proteins 0.000 claims 1
- 101710176758 Replication protein A 70 kDa DNA-binding subunit Proteins 0.000 claims 1
- 101710176276 SSB protein Proteins 0.000 claims 1
- 101710126859 Single-stranded DNA-binding protein Proteins 0.000 claims 1
- 101710142606 Sliding clamp Proteins 0.000 claims 1
- 101100117496 Sulfurisphaera ohwakuensis pol-alpha gene Proteins 0.000 claims 1
- NLTUCYMLOPLUHL-KQYNXXCUSA-N adenosine 5'-[gamma-thio]triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O NLTUCYMLOPLUHL-KQYNXXCUSA-N 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 claims 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35856302P | 2002-02-21 | 2002-02-21 | |
| PCT/US2003/005492 WO2003072805A2 (en) | 2002-02-21 | 2003-02-21 | Recombinase polymerase amplification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009026788A Division JP4448188B2 (ja) | 2002-02-21 | 2009-02-06 | リコンビナーゼポリメラーゼ増幅 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005518215A JP2005518215A (ja) | 2005-06-23 |
| JP2005518215A5 true JP2005518215A5 (enExample) | 2008-03-27 |
| JP4340543B2 JP4340543B2 (ja) | 2009-10-07 |
Family
ID=27765964
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571485A Expired - Lifetime JP4340543B2 (ja) | 2002-02-21 | 2003-02-21 | リコンビナーゼポリメラーゼ増幅 |
| JP2009026788A Expired - Lifetime JP4448188B2 (ja) | 2002-02-21 | 2009-02-06 | リコンビナーゼポリメラーゼ増幅 |
| JP2009278020A Expired - Lifetime JP5271244B2 (ja) | 2002-02-21 | 2009-12-07 | リコンビナーゼポリメラーゼ増幅 |
| JP2012203178A Withdrawn JP2012249637A (ja) | 2002-02-21 | 2012-09-14 | リコンビナーゼポリメラーゼ増幅 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009026788A Expired - Lifetime JP4448188B2 (ja) | 2002-02-21 | 2009-02-06 | リコンビナーゼポリメラーゼ増幅 |
| JP2009278020A Expired - Lifetime JP5271244B2 (ja) | 2002-02-21 | 2009-12-07 | リコンビナーゼポリメラーゼ増幅 |
| JP2012203178A Withdrawn JP2012249637A (ja) | 2002-02-21 | 2012-09-14 | リコンビナーゼポリメラーゼ増幅 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US7270981B2 (enExample) |
| EP (4) | EP1992706B1 (enExample) |
| JP (4) | JP4340543B2 (enExample) |
| AT (1) | ATE400663T1 (enExample) |
| AU (1) | AU2003215391B2 (enExample) |
| CA (1) | CA2476481C (enExample) |
| DE (1) | DE60322044D1 (enExample) |
| DK (1) | DK1499738T3 (enExample) |
| ES (1) | ES2310237T3 (enExample) |
| PT (1) | PT1499738E (enExample) |
| WO (1) | WO2003072805A2 (enExample) |
Families Citing this family (165)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2305289T3 (es) | 2001-04-20 | 2008-11-01 | The Penn State Research Foundation | Metodo de manipulacion de acidos nucleicos. |
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| DK1499738T3 (da) * | 2002-02-21 | 2008-11-17 | Asm Scient Inc | Recombinase-polymerease-amplifikation |
| DE60324810D1 (de) * | 2002-09-20 | 2009-01-02 | New England Biolabs Inc | HELICASE-ABHuNGIGE AMPLIFIKATION VON NUKLEINSUREN |
| US20040241732A1 (en) * | 2003-04-11 | 2004-12-02 | Chu-An Chang | Method of generating long nucleic acid molecules of defined sequence |
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| EP1759012B1 (en) * | 2004-06-01 | 2013-05-22 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| AU2011202896B2 (en) * | 2004-06-01 | 2012-12-06 | Abbott Diagnostics Scarborough, Inc. | Recombinase Polymerase Amplification |
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| JP4534138B2 (ja) * | 2004-12-21 | 2010-09-01 | アイシン精機株式会社 | 核酸増幅反応における高度好熱菌由来タンパク質の活性化方法およびその利用 |
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| ES2420831T3 (es) * | 2005-07-25 | 2013-08-27 | Alere San Diego, Inc. | Procedimientos para multiplexar la ampliación de la recombinasa polimerasa |
| US7368265B2 (en) * | 2006-01-23 | 2008-05-06 | Compass Genetics, Llc | Selective genome amplification |
| US8071308B2 (en) * | 2006-05-04 | 2011-12-06 | Alere San Diego, Inc. | Recombinase polymerase amplification |
| CN103203256B (zh) | 2006-07-19 | 2015-09-23 | 博纳基因技术有限公司 | 纳米口装置阵列:它们的制备以及在大分子分析中的应用 |
| AU2008232616B2 (en) | 2007-03-28 | 2014-08-07 | Bionano Genomics, Inc. | Methods of macromolecular analysis using nanochannel arrays |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| CA2729159C (en) | 2008-06-30 | 2020-01-14 | Bionanomatrix, Inc. | Methods and devices for single-molecule whole genome analysis |
| EP2291533B2 (en) | 2008-07-02 | 2020-09-30 | Illumina Cambridge Limited | Using populations of beads for the fabrication of arrays on surfaces |
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-
2011
- 2011-07-28 US US13/192,806 patent/US8460875B2/en not_active Expired - Fee Related
-
2012
- 2012-09-14 JP JP2012203178A patent/JP2012249637A/ja not_active Withdrawn
-
2013
- 2013-06-06 US US13/911,268 patent/US9340825B2/en not_active Expired - Fee Related
-
2016
- 2016-04-15 US US15/099,754 patent/US20170044598A1/en not_active Abandoned
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