JP2017509350A - ガイドrnaの生成のための方法および組成物 - Google Patents
ガイドrnaの生成のための方法および組成物 Download PDFInfo
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- JP2017509350A JP2017509350A JP2016560684A JP2016560684A JP2017509350A JP 2017509350 A JP2017509350 A JP 2017509350A JP 2016560684 A JP2016560684 A JP 2016560684A JP 2016560684 A JP2016560684 A JP 2016560684A JP 2017509350 A JP2017509350 A JP 2017509350A
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2330/00—Production
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- C12N2330/51—Specially adapted vectors
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- C12N2830/00—Vector systems having a special element relevant for transcription
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461974672P | 2014-04-03 | 2014-04-03 | |
| US61/974,672 | 2014-04-03 | ||
| PCT/US2015/024196 WO2015153940A1 (en) | 2014-04-03 | 2015-04-03 | Methods and compositions for the production of guide rna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017509350A true JP2017509350A (ja) | 2017-04-06 |
| JP2017509350A5 JP2017509350A5 (enExample) | 2018-05-31 |
Family
ID=52997563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016560684A Pending JP2017509350A (ja) | 2014-04-03 | 2015-04-03 | ガイドrnaの生成のための方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170022499A1 (enExample) |
| EP (1) | EP3126503A1 (enExample) |
| JP (1) | JP2017509350A (enExample) |
| CN (1) | CN106170550A (enExample) |
| WO (1) | WO2015153940A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017502683A (ja) * | 2014-01-14 | 2017-01-26 | ラム セラピューティクス, インコーポレイテッド | 変異誘発方法 |
| JP2023532864A (ja) * | 2020-06-30 | 2023-08-01 | ザ ユニバーシティー コート オブ ザ ユニバーシティー オブ エジンバラ | 導入遺伝子発現系 |
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| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| WO2014204578A1 (en) | 2013-06-21 | 2014-12-24 | The General Hospital Corporation | Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing |
| WO2015099850A1 (en) * | 2013-12-26 | 2015-07-02 | The General Hospital Corporation | Multiplex guide rnas |
| KR102405549B1 (ko) | 2013-03-15 | 2022-06-08 | 더 제너럴 하스피탈 코포레이션 | Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용 |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US10584358B2 (en) | 2013-10-30 | 2020-03-10 | North Carolina State University | Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri |
| ES2670983T3 (es) | 2013-11-07 | 2018-06-04 | Editas Medicine, Inc. | Métodos y composiciones relacionados con CRISPR con ARNg rectores |
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| WO2016070037A2 (en) * | 2014-10-31 | 2016-05-06 | Massachusetts Institute Of Technology | Massively parallel combinatorial genetics for crispr |
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| KR102902492B1 (ko) | 2015-06-15 | 2025-12-18 | 노쓰 캐롤라이나 스테이트 유니버시티 | 핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물 |
| US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
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| EP3219799A1 (en) | 2016-03-17 | 2017-09-20 | IMBA-Institut für Molekulare Biotechnologie GmbH | Conditional crispr sgrna expression |
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| EP3126503A1 (en) | 2017-02-08 |
| WO2015153940A1 (en) | 2015-10-08 |
| CN106170550A (zh) | 2016-11-30 |
| US20170022499A1 (en) | 2017-01-26 |
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