|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
WO2010138263A2
(en)
|
2009-05-28 |
2010-12-02 |
University Of Massachusetts |
Novel aav 's and uses thereof
|
|
EP2517557B2
(en)
|
2009-07-08 |
2023-08-02 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
WO2011133901A2
(en)
|
2010-04-23 |
2011-10-27 |
University Of Massachusetts |
Aav-based treatment of cholesterol-related disorders
|
|
WO2011140441A2
(en)
|
2010-05-06 |
2011-11-10 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
EP2569430B1
(en)
|
2010-05-12 |
2018-10-17 |
The Trustees of Columbia University in the City of New York |
Methods for producing enteroendocrine cells that make and secrete insulin
|
|
EA201391373A1
(ru)
|
2011-03-23 |
2014-07-30 |
Пайонир Хай-Бред Интернэшнл, Инк. |
Способы получения сложного локуса трансгенных признаков
|
|
DE12722942T1
(de)
|
2011-03-31 |
2021-09-30 |
Modernatx, Inc. |
Freisetzung und formulierung von manipulierten nukleinsäuren
|
|
ES2661680T3
(es)
|
2011-04-21 |
2018-04-03 |
University Of Massachusetts |
Composiciones basadas en VAAr y métodos para tratar deficiencias de alfa-1 anti-tripsina
|
|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
BR112014006394A2
(pt)
|
2011-09-19 |
2017-03-28 |
Kymab Ltd |
manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
|
|
WO2013045916A1
(en)
|
2011-09-26 |
2013-04-04 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
GB201117313D0
(en)
|
2011-10-07 |
2011-11-16 |
Gt Biolog Ltd |
Bacterium for use in medicine
|
|
JP2014531908A
(ja)
|
2011-10-14 |
2014-12-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
構造アッセンブリによる配列決定
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9458450B2
(en)
|
2012-03-15 |
2016-10-04 |
Flodesign Sonics, Inc. |
Acoustophoretic separation technology using multi-dimensional standing waves
|
|
US10322949B2
(en)
|
2012-03-15 |
2019-06-18 |
Flodesign Sonics, Inc. |
Transducer and reflector configurations for an acoustophoretic device
|
|
US9745548B2
(en)
|
2012-03-15 |
2017-08-29 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9950282B2
(en)
|
2012-03-15 |
2018-04-24 |
Flodesign Sonics, Inc. |
Electronic configuration and control for acoustic standing wave generation
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US10967298B2
(en)
|
2012-03-15 |
2021-04-06 |
Flodesign Sonics, Inc. |
Driver and control for variable impedence load
|
|
US10689609B2
(en)
|
2012-03-15 |
2020-06-23 |
Flodesign Sonics, Inc. |
Acoustic bioreactor processes
|
|
US9752113B2
(en)
|
2012-03-15 |
2017-09-05 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9637739B2
(en)
*
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
US10039777B2
(en)
|
2012-03-20 |
2018-08-07 |
Neuro-Lm Sas |
Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
US10737953B2
(en)
|
2012-04-20 |
2020-08-11 |
Flodesign Sonics, Inc. |
Acoustophoretic method for use in bioreactors
|
|
EP2847335B1
(en)
|
2012-04-25 |
2018-06-27 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated targeting with large targeting vectors
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
US20130297023A1
(en)
*
|
2012-05-07 |
2013-11-07 |
Hee-Jeong Im Sampen |
Methods and Devices For Treating Intervertebral Disc Disease
|
|
NZ714353A
(en)
|
2012-05-25 |
2017-05-26 |
Univ California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
JP6225182B2
(ja)
|
2012-07-11 |
2017-11-01 |
サンガモ セラピューティクス, インコーポレイテッド |
リソソーム貯蔵疾患の処置のための方法および組成物
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
DE202013012597U1
(de)
|
2012-10-23 |
2017-11-21 |
Toolgen, Inc. |
Zusammensetzung zum Spalten einer Ziel-DNA, umfassend eine für die Ziel-DNA spezifische guide-RNA und eine Cas-Protein-codierende Nukleinsäure oder ein Cas-Protein, sowie deren Verwendung
|
|
AU2013355214B2
(en)
|
2012-12-06 |
2017-06-15 |
Sigma-Aldrich Co. Llc |
Crispr-based genome modification and regulation
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
EP2940140B1
(en)
|
2012-12-12 |
2019-03-27 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
PL2931898T3
(pl)
|
2012-12-12 |
2016-09-30 |
Le Cong |
Projektowanie i optymalizacja systemów, sposoby i kompozycje do manipulacji sekwencją z domenami funkcjonalnymi
|
|
EP2898075B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
|
EP4286403A3
(en)
|
2012-12-12 |
2024-02-14 |
The Broad Institute Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
SG11201504523UA
(en)
|
2012-12-12 |
2015-07-30 |
Broad Inst Inc |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
KR20220139433A
(ko)
*
|
2012-12-17 |
2022-10-14 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Rna-가이드된 인간 게놈 조작
|
|
AU2014207618A1
(en)
*
|
2013-01-16 |
2015-08-06 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
|
EP2971184B1
(en)
|
2013-03-12 |
2019-04-17 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
CA2905432C
(en)
|
2013-03-14 |
2021-09-14 |
Caribou Biosciences, Inc. |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US11332719B2
(en)
*
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
EP2971165A4
(en)
|
2013-03-15 |
2016-11-23 |
Moderna Therapeutics Inc |
DISSOLUTION OF DNA FRAGMENTS IN MRNA MANUFACTURING METHODS
|
|
EP2970208A4
(en)
*
|
2013-03-15 |
2016-11-30 |
Gen Hospital Corp |
SPECIFICITY INCREASES FOR RNA-MEDIATED CHANGES
|
|
EP2971161B1
(en)
|
2013-03-15 |
2018-12-26 |
ModernaTX, Inc. |
Ribonucleic acid purification
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
CN105518146B
(zh)
|
2013-04-04 |
2022-07-15 |
哈佛学院校长同事会 |
利用CRISPR/Cas系统的基因组编辑的治疗性用途
|
|
JP6576904B2
(ja)
*
|
2013-04-04 |
2019-09-18 |
トラスティーズ・オブ・ダートマス・カレッジ |
HIV−1プロウイルスDNAのinvivo切除のための組成物及び方法
|
|
GB201306536D0
(en)
|
2013-04-10 |
2013-05-22 |
Gt Biolog Ltd |
Polypeptide and immune modulation
|
|
BR112015026197B1
(pt)
|
2013-04-16 |
2022-12-06 |
Regeneron Pharmaceuticals, Inc |
Método para modificação marcada de um lócus genômico de interesse em uma célula de rato pluripotente
|
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
|
HK1223401A1
(zh)
*
|
2013-05-15 |
2017-07-28 |
桑格摩生物科学股份有限公司 |
用於治疗遗传病状的方法和组合物
|
|
US20160122774A1
(en)
*
|
2013-05-29 |
2016-05-05 |
Cellectis |
A method for producing precise dna cleavage using cas9 nickase activity
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
MY177814A
(en)
*
|
2013-06-04 |
2020-09-23 |
Harvard College |
Rna-guided transcriptional regulation
|
|
EP3011031B1
(en)
|
2013-06-17 |
2020-09-30 |
The Broad Institute Inc. |
Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたCRISPR−Cas二重ニッカーゼ系、方法および組成物
|
|
EP3011029B1
(en)
|
2013-06-17 |
2019-12-11 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
WO2014204729A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
WO2015006498A2
(en)
*
|
2013-07-09 |
2015-01-15 |
President And Fellows Of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
SG11201600060VA
(en)
*
|
2013-07-10 |
2016-02-26 |
Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
HUE056760T2
(hu)
|
2013-07-11 |
2022-03-28 |
Modernatx Inc |
A CRISPR-hez kapcsolódó fehérjéket és a szintetikus SGRNS-ket kódoló szintetikus polinukleotidokat tartalmazó készítmények és felhasználási módjaik
|
|
EP3022304B1
(en)
*
|
2013-07-19 |
2018-12-26 |
Larix Biosciences LLC |
Methods and compositions for producing double allele knock outs
|
|
US11306328B2
(en)
*
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CA2922089C
(en)
|
2013-08-22 |
2022-07-05 |
E. I. Du Pont De Nemours And Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
KR20160060659A
(ko)
|
2013-08-29 |
2016-05-30 |
템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 |
Hiv 감염증의 rna-유도 치료를 위한 방법 및 조성물
|
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9745569B2
(en)
|
2013-09-13 |
2017-08-29 |
Flodesign Sonics, Inc. |
System for generating high concentration factors for low cell density suspensions
|
|
CN105637087A
(zh)
*
|
2013-09-18 |
2016-06-01 |
科马布有限公司 |
方法、细胞与生物体
|
|
JP7133902B2
(ja)
|
2013-10-01 |
2022-09-09 |
カイマブ・リミテッド |
動物モデル及び治療用分子
|
|
WO2015051169A2
(en)
|
2013-10-02 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
EP4372090A3
(en)
|
2013-11-07 |
2024-08-07 |
Editas Medicine, Inc. |
Crispr-related methods and compositions with governing grnas
|
|
EP3375877A1
(en)
*
|
2013-11-18 |
2018-09-19 |
Crispr Therapeutics AG |
Crispr-cas system materials and methods
|
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
SI3080279T1
(sl)
|
2013-12-11 |
2019-01-31 |
Regeneron Pharmaceuticals, Inc. |
Postopki in sestavki za ciljano spremembo genoma
|
|
KR102170502B1
(ko)
|
2013-12-11 |
2020-10-28 |
리제너론 파마슈티칼스 인코포레이티드 |
게놈의 표적화된 변형을 위한 방법 및 조성물
|
|
EP4219699A1
(en)
|
2013-12-12 |
2023-08-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
BR112016013213A2
(pt)
|
2013-12-12 |
2017-12-05 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas
|
|
KR20160097327A
(ko)
|
2013-12-12 |
2016-08-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유전자 산물, 구조 정보 및 유도성 모듈형 cas 효소의 발현의 변경을 위한 crispr-cas 시스템 및 방법
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
EP3080261B1
(en)
|
2013-12-12 |
2019-05-22 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
EP3079725B1
(en)
|
2013-12-12 |
2019-10-16 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
|
EP3092049A1
(en)
|
2014-01-08 |
2016-11-16 |
Flodesign Sonics Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
|
EP4249036A3
(en)
*
|
2014-01-31 |
2023-10-25 |
Factor Bioscience Inc. |
Methods and products for nucleic acid production and delivery
|
|
RS60492B1
(sr)
|
2014-02-11 |
2020-08-31 |
Univ Colorado Regents |
Multipleksirani genomski inženjering omogućen pomoću crispr
|
|
KR20160130392A
(ko)
|
2014-02-18 |
2016-11-11 |
듀크 유니버시티 |
바이러스 복제의 불활성화를 위한 조성물 및 그의 제조 및 사용 방법
|
|
WO2015127128A2
(en)
|
2014-02-19 |
2015-08-27 |
University Of Massachusetts |
Recombinant aavs having useful transcytosis properties
|
|
CN106817904A
(zh)
|
2014-02-27 |
2017-06-09 |
博德研究所 |
T细胞平衡基因表达、物质组合物及其使用方法
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
DK3116997T3
(da)
|
2014-03-10 |
2019-08-19 |
Editas Medicine Inc |
Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10)
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3750907A3
(en)
|
2014-03-18 |
2021-04-28 |
University of Massachusetts |
Raav-based compositions and methods for treating amyotrophic lateral sclerosis
|
|
US11242525B2
(en)
|
2014-03-26 |
2022-02-08 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating sickle cell disease
|
|
WO2015153780A1
(en)
|
2014-04-02 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
US10975391B2
(en)
|
2014-04-25 |
2021-04-13 |
University Of Massachusetts |
Recombinant AAV vectors useful for reducing immunity against transgene products
|
|
CA2947270A1
(en)
*
|
2014-04-28 |
2015-11-05 |
Rxi Pharmaceuticals Corporation |
Methods for treating cancer using nucleic acids targeting mdm2 or mycn
|
|
WO2015168800A1
(en)
*
|
2014-05-09 |
2015-11-12 |
UNIVERSITé LAVAL |
Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system
|
|
JP6570188B2
(ja)
*
|
2014-05-20 |
2019-09-04 |
国立大学法人北海道大学 |
siRNA細胞内送達のための脂質膜構造体
|
|
EP3712254A1
(en)
|
2014-05-28 |
2020-09-23 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into gastric tissues through directed differentiation
|
|
EP3149171A1
(en)
*
|
2014-05-30 |
2017-04-05 |
The Board of Trustees of The Leland Stanford Junior University |
Compositions and methods of delivering treatments for latent viral infections
|
|
WO2015187825A2
(en)
|
2014-06-03 |
2015-12-10 |
University Of Massachusetts |
Compositions and methods for modulating dysferlin expression
|
|
ES3019688T3
(en)
|
2014-06-06 |
2025-05-21 |
Regeneron Pharma |
Methods and compositions for modifying a targeted locus
|
|
WO2015196128A2
(en)
|
2014-06-19 |
2015-12-23 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
KR102425438B1
(ko)
|
2014-06-23 |
2022-07-27 |
더 제너럴 하스피탈 코포레이션 |
서열결정에 의해 평가된 DSB의 게놈 전체에 걸친 비편향된 확인 (GUIDE-Seq)
|
|
AU2015280120B2
(en)
|
2014-06-23 |
2017-05-25 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated DNA assembly
|
|
WO2015200901A1
(en)
|
2014-06-26 |
2015-12-30 |
The Trustees Of Columbia University In The City Of New York |
Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
|
|
RU2771532C2
(ru)
|
2014-06-26 |
2022-05-05 |
Регенерон Фармасьютикалз, Инк. |
Способы и композиции для нацеленных генетических модификаций и способы их применения
|
|
US9744483B2
(en)
|
2014-07-02 |
2017-08-29 |
Flodesign Sonics, Inc. |
Large scale acoustic separation device
|
|
US10760040B1
(en)
|
2014-07-03 |
2020-09-01 |
NanoCav, LLC |
Mechanical transfection devices and methods
|
|
US10081816B1
(en)
*
|
2014-07-03 |
2018-09-25 |
Nant Holdings Ip, Llc |
Mechanical transfection devices and methods
|
|
EP2966170A1
(en)
*
|
2014-07-10 |
2016-01-13 |
Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - |
HBV inactivation
|
|
BR122023024818A2
(pt)
*
|
2014-07-11 |
2023-12-26 |
Pioneer Hi-Bred International, Inc. |
Rna guia, polinucleotídeo e complexo de ribonucleoproteínas
|
|
BR112017000482A2
(pt)
|
2014-07-11 |
2017-11-07 |
Du Pont |
métodos para produzir uma planta mutante e para gerar uma planta, planta, semente, rna, métodos para produzir uma célula, para duplicar um fragmento gênico, para substituir uma primeira sequência promotora, para inserir um elemento regulador em uma sequência de nucleotídeos e para inserir um íntron em uma sequência de nucleotídeos, planta de milho e célula vegetal
|
|
US10179932B2
(en)
|
2014-07-11 |
2019-01-15 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
US10407683B2
(en)
|
2014-07-16 |
2019-09-10 |
Modernatx, Inc. |
Circular polynucleotides
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
US9850521B2
(en)
*
|
2014-08-01 |
2017-12-26 |
Agilent Technologies, Inc. |
In vitro assay buffer for Cas9
|
|
EP3180034B1
(en)
*
|
2014-08-11 |
2022-04-20 |
The Board of Regents of The University of Texas System |
Prevention of muscular dystrophy by crispr/cas9-mediated gene editing
|
|
US11071289B2
(en)
|
2014-08-14 |
2021-07-27 |
Biocytogen Boston Corp |
DNA knock-in system
|
|
ES2780904T3
(es)
|
2014-08-17 |
2020-08-27 |
Broad Inst Inc |
Edición genómica usando nickasas Cas9
|
|
AU2015308910B2
(en)
*
|
2014-08-27 |
2017-12-07 |
Caribou Biosciences, Inc. |
Methods for increasing Cas9-mediated engineering efficiency
|
|
EP3188763B1
(en)
|
2014-09-02 |
2020-05-13 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification
|
|
WO2016040030A1
(en)
|
2014-09-12 |
2016-03-17 |
E. I. Du Pont De Nemours And Company |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016049024A2
(en)
*
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
CN104293831A
(zh)
*
|
2014-09-28 |
2015-01-21 |
上海云舜生物技术有限公司 |
建立高血压小鼠模型的方法及其用途
|
|
WO2016054554A1
(en)
|
2014-10-03 |
2016-04-07 |
University Of Massachusetts |
Heterologous targeting peptide grafted aavs
|
|
JP6842410B2
(ja)
|
2014-10-03 |
2021-03-17 |
ユニバーシティ オブ マサチューセッツ |
新規の高効率ライブラリーにより同定されるaavベクター
|
|
WO2016057850A1
(en)
*
|
2014-10-09 |
2016-04-14 |
Seattle Children' S Hospital (Dba Seattle Children' S Research Institute) |
Long poly (a) plasmids and methods for introduction of long poly (a) sequences into the plasmid
|
|
CA2964114A1
(en)
|
2014-10-09 |
2016-04-14 |
Anthrogenesis Corporation |
Placenta-derived adherent cell exosomes and uses thereof
|
|
JP6723230B2
(ja)
*
|
2014-10-09 |
2020-07-15 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
神経障害性疼痛を治療するためのcsf1−dap12経路のメンバー遺伝子の標的破壊
|
|
US20180250424A1
(en)
|
2014-10-10 |
2018-09-06 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
KR20170070136A
(ko)
|
2014-10-15 |
2017-06-21 |
리제너론 파마슈티칼스 인코포레이티드 |
만능성 세포를 생성하거나 유지하는 방법 및 조성물
|
|
EP3207131B1
(en)
*
|
2014-10-17 |
2022-09-28 |
Howard Hughes Medical Institute |
Genomic probes
|
|
EP3207123A1
(en)
|
2014-10-17 |
2017-08-23 |
Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center |
In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
|
|
JP7023108B2
(ja)
|
2014-10-21 |
2022-02-21 |
ユニバーシティ オブ マサチューセッツ |
組み換えaavバリアントおよびその使用
|
|
WO2016069591A2
(en)
|
2014-10-27 |
2016-05-06 |
The Broad Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
WO2016069912A1
(en)
|
2014-10-29 |
2016-05-06 |
Massachusetts Eye And Ear Infirmary |
Efficient delivery of therapeutic molecules in vitro and in vivo
|
|
CN107429246B
(zh)
*
|
2014-10-31 |
2021-06-01 |
麻省理工学院 |
用于crispr的大规模并行组合遗传学
|
|
BR112017009497A2
(pt)
|
2014-11-05 |
2018-02-06 |
Voyager Therapeutics, Inc. |
polinucleotídeos de aadc para o tratamento da doença de parkinson
|
|
WO2016073955A2
(en)
|
2014-11-06 |
2016-05-12 |
President And Fellows Of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
EP4464338A3
(en)
|
2014-11-07 |
2025-02-12 |
Editas Medicine, Inc. |
Systems for improving crispr/cas-mediated genome-editing
|
|
US10570395B2
(en)
|
2014-11-14 |
2020-02-25 |
Voyager Therapeutics, Inc. |
Modulatory polynucleotides
|
|
CA2967367C
(en)
|
2014-11-14 |
2023-05-16 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
CN113444747B
(zh)
|
2014-11-21 |
2025-02-11 |
瑞泽恩制药公司 |
使用成对向导rna进行靶向遗传修饰的方法和组合物
|
|
US11168369B2
(en)
|
2014-11-25 |
2021-11-09 |
The Brigham And Women's Hospital, Inc. |
Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
EP3224362B1
(en)
|
2014-11-26 |
2024-09-25 |
The Regents of The University of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
KR102763527B1
(ko)
|
2014-12-03 |
2025-02-05 |
애질런트 테크놀로지스, 인크. |
화학적 변형을 갖는 가이드 rna
|
|
US9888673B2
(en)
|
2014-12-10 |
2018-02-13 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
WO2016094880A1
(en)
*
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
EP3985115A1
(en)
|
2014-12-12 |
2022-04-20 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
US10196613B2
(en)
|
2014-12-19 |
2019-02-05 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
CN107208113A
(zh)
|
2014-12-19 |
2017-09-26 |
瑞泽恩制药公司 |
用于通过单步多重靶向进行靶向遗传修饰的方法和组合物
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
ES2658310T3
(es)
|
2014-12-23 |
2018-03-09 |
4D Pharma Research Limited |
Una cepa de bacteroides thetaiotaomicron y su uso en la reducción de la inflamación
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
PL3193901T3
(pl)
|
2014-12-23 |
2018-10-31 |
4D Pharma Research Limited |
Polipeptyd pyrynowy i immunomodulacja
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
US11339399B2
(en)
|
2014-12-31 |
2022-05-24 |
Viridos, Inc. |
Compositions and methods for high efficiency in vivo genome editing
|
|
WO2016114972A1
(en)
|
2015-01-12 |
2016-07-21 |
The Regents Of The University Of California |
Heterodimeric cas9 and methods of use thereof
|
|
US10059940B2
(en)
*
|
2015-01-27 |
2018-08-28 |
Minghong Zhong |
Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
|
|
WO2016123243A1
(en)
|
2015-01-28 |
2016-08-04 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
JP6835726B2
(ja)
|
2015-01-28 |
2021-02-24 |
パイオニア ハイ−ブレッド インターナショナル, インコーポレイテッド |
Crisprハイブリッドdna/rnaポリヌクレオチドおよび使用方法
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
WO2016131009A1
(en)
*
|
2015-02-13 |
2016-08-18 |
University Of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
WO2016138488A2
(en)
|
2015-02-26 |
2016-09-01 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
US11261466B2
(en)
|
2015-03-02 |
2022-03-01 |
Sinai Health System |
Homologous recombination factors
|
|
CN107532161A
(zh)
|
2015-03-03 |
2018-01-02 |
通用医疗公司 |
具有改变的PAM特异性的工程化CRISPR‑Cas9核酸酶
|
|
CN104673816A
(zh)
*
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
|
CN106032540B
(zh)
*
|
2015-03-16 |
2019-10-25 |
中国科学院上海生命科学研究院 |
CRISPR/Cas9核酸内切酶体系的腺相关病毒载体构建及其用途
|
|
GB2536650A
(en)
|
2015-03-24 |
2016-09-28 |
Augmedics Ltd |
Method and system for combining video-based and optic-based augmented reality in a near eye display
|
|
WO2016154176A1
(en)
*
|
2015-03-26 |
2016-09-29 |
Yale University |
Methods and compositions for modifying endothelial cells
|
|
WO2016160389A1
(en)
|
2015-03-27 |
2016-10-06 |
E I Du Pont De Nemours And Company |
Soybean u6 small nuclear rna gene promoters and their use in constitutive expression of small rna genes in plants
|
|
CA3000187A1
(en)
*
|
2015-04-02 |
2016-10-06 |
Agenovir Corporation |
Gene delivery methods and compositions
|
|
WO2016161446A1
(en)
*
|
2015-04-03 |
2016-10-06 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
|
JP6873911B2
(ja)
|
2015-04-06 |
2021-05-19 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
初代細胞において標的核酸の遺伝子調節を誘導するためにインビトロで行う方法
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
EP4019975A1
(en)
|
2015-04-24 |
2022-06-29 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
US11046955B2
(en)
|
2015-04-24 |
2021-06-29 |
University Of Massachusetts |
Modified AAV constructs and uses thereof
|
|
US11420136B2
(en)
|
2016-10-19 |
2022-08-23 |
Flodesign Sonics, Inc. |
Affinity cell extraction by acoustics
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
US11021699B2
(en)
|
2015-04-29 |
2021-06-01 |
FioDesign Sonics, Inc. |
Separation using angled acoustic waves
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
HK1254190A1
(zh)
|
2015-05-08 |
2019-07-12 |
President And Fellows Of Harvard College |
通用供体干细胞和相关方法
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
JP7030522B2
(ja)
|
2015-05-11 |
2022-03-07 |
エディタス・メディシン、インコーポレイテッド |
幹細胞における遺伝子編集のための最適化crispr/cas9システムおよび方法
|
|
WO2016187717A1
(en)
*
|
2015-05-26 |
2016-12-01 |
Exerkine Corporation |
Exosomes useful for genome editing
|
|
WO2016196282A1
(en)
*
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Compositions and methods for cell targeted hpv treatment
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
EA037359B1
(ru)
|
2015-06-01 |
2021-03-17 |
Тэмпл Юниверсити - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн |
Способы и композиции для рнк-направляемого лечения инфекции, вызываемой вич
|
|
US10883103B2
(en)
|
2015-06-02 |
2021-01-05 |
Monsanto Technology Llc |
Compositions and methods for delivery of a polynucleotide into a plant
|
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
|
GB201509578D0
(en)
*
|
2015-06-03 |
2015-07-15 |
Univ Singapore |
Vectors
|
|
US10392607B2
(en)
|
2015-06-03 |
2019-08-27 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
|
JP7396783B2
(ja)
|
2015-06-09 |
2023-12-12 |
エディタス・メディシン、インコーポレイテッド |
移植を改善するためのcrispr/cas関連方法および組成物
|
|
PE20180243A1
(es)
|
2015-06-15 |
2018-01-31 |
4D Pharma Res Ltd |
Composiciones que comprenden cepas bacterianas
|
|
MA41060B1
(fr)
|
2015-06-15 |
2019-11-29 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
CN114984057A
(zh)
|
2015-06-15 |
2022-09-02 |
4D制药研究有限公司 |
包含细菌菌株的组合物
|
|
MA41010B1
(fr)
|
2015-06-15 |
2020-01-31 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
HUE058252T2
(hu)
|
2015-06-15 |
2022-07-28 |
4D Pharma Res Ltd |
Baktériumtörzseket tartalmazó készítmények
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
RU2752834C2
(ru)
|
2015-06-18 |
2021-08-09 |
Те Брод Инститьют, Инк. |
Мутации фермента crispr, уменьшающие нецелевые эффекты
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
CA3012607A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Crispr enzymes and systems
|
|
FI3430134T3
(fi)
|
2015-06-18 |
2023-01-13 |
|
Uusia CRISPR-entsyymejä ja järjestelmiä
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
WO2016205688A2
(en)
*
|
2015-06-18 |
2016-12-22 |
Bowles Robert D |
Rna-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
EP3316159A4
(en)
|
2015-06-25 |
2019-08-14 |
Advanced Telecommunications Research Institute International |
PREDICTIVE EQUIPMENT BASED ON A SYSTEM ASSOCIATED WITH SEVERAL INSTITUTIONS AND PREDICTION PROGRAM
|
|
WO2016210416A2
(en)
*
|
2015-06-26 |
2016-12-29 |
The Trustees Of Columbia University In The City Of New York |
Genetically modified ips cells that carry a marker to report expression of neurogenin3, tph2, foxo1 and/or insulin genes
|
|
JP2018519811A
(ja)
|
2015-06-29 |
2018-07-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
修飾crispr rna及び修飾単一crispr rnaならびにその使用
|
|
US10456452B2
(en)
|
2015-07-02 |
2019-10-29 |
Poseida Therapeutics, Inc. |
Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles
|
|
US20170000743A1
(en)
*
|
2015-07-02 |
2017-01-05 |
Vindico NanoBio Technology Inc. |
Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles
|
|
WO2017007825A1
(en)
*
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
CN116212052A
(zh)
*
|
2015-07-25 |
2023-06-06 |
哈比卜·弗罗斯特 |
用于为癌症和其他病理状态提供治疗或治愈的系统、装置和方法
|
|
US11474085B2
(en)
|
2015-07-28 |
2022-10-18 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
US11459540B2
(en)
|
2015-07-28 |
2022-10-04 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
US20180208945A1
(en)
*
|
2015-07-28 |
2018-07-26 |
Danisco Us Inc. |
Genome editing systems and methods of use
|
|
GB2595063B
(en)
*
|
2015-07-31 |
2022-03-09 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
EP4512819A3
(en)
|
2015-08-12 |
2025-08-06 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
|
EP3334746B1
(en)
|
2015-08-14 |
2021-11-24 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
EP3337908A4
(en)
|
2015-08-18 |
2019-01-23 |
The Broad Institute, Inc. |
METHOD AND COMPOSITIONS FOR CHANGING THE FUNCTION AND STRUCTURE OF CHROMATIN GRINDING AND / OR DOMAINS
|
|
CN108351350B
(zh)
*
|
2015-08-25 |
2022-02-18 |
杜克大学 |
使用rna指导型内切核酸酶改善基因组工程特异性的组合物和方法
|
|
HK1257676A1
(zh)
|
2015-08-28 |
2019-10-25 |
The General Hospital Corporation |
工程化 crispr-cas 9 核酸酶
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
IL241462A0
(en)
|
2015-09-10 |
2015-11-30 |
Yeda Res & Dev |
Heterologous engineering of betalain pigments in plants
|
|
EP3347467B1
(en)
|
2015-09-11 |
2021-06-23 |
The General Hospital Corporation |
Full interrogation of nuclease dsbs and sequencing (find-seq)
|
|
WO2017049275A2
(en)
|
2015-09-17 |
2017-03-23 |
Moderna Therapeutics, Inc. |
Polynucleotides containing a stabilizing tail region
|
|
EP3786294A1
(en)
|
2015-09-24 |
2021-03-03 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
KR20180053748A
(ko)
|
2015-09-30 |
2018-05-23 |
더 제너럴 하스피탈 코포레이션 |
시퀀싱(circle-seq)에 의한 절단 반응의 포괄적인 시험관내 보고
|
|
US10760081B2
(en)
|
2015-10-07 |
2020-09-01 |
New York University |
Compositions and methods for enhancing CRISPR activity by POLQ inhibition
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
EP3362571A4
(en)
|
2015-10-13 |
2019-07-10 |
Duke University |
GENOM ENGINEERING WITH TYPE I CRISPR SYSTEMS IN EUKARYOTIC CELLS
|
|
EP3365441A1
(en)
|
2015-10-22 |
2018-08-29 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
|
EP3364997B1
(en)
|
2015-10-22 |
2024-01-17 |
University of Massachusetts |
Aspartoacylase gene therapy in the treatment of canavan disease
|
|
EP3364996B1
(en)
|
2015-10-22 |
2021-08-25 |
University of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
US12043852B2
(en)
|
2015-10-23 |
2024-07-23 |
President And Fellows Of Harvard College |
Evolved Cas9 proteins for gene editing
|
|
WO2017074788A1
(en)
|
2015-10-27 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
EP3368054A4
(en)
|
2015-10-28 |
2019-07-03 |
Voyager Therapeutics, Inc. |
REGULATORY EXPRESSION USING THE ADENO-ASSOCIATED VIRUS (AAV)
|
|
WO2017075265A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute, Inc. |
Multiplex analysis of single cell constituents
|
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
HK1252878A1
(zh)
|
2015-11-03 |
2019-06-06 |
President And Fellows Of Harvard College |
用於含有基质的三维核酸的体积成像的方法和设备
|
|
WO2017083274A1
(en)
*
|
2015-11-09 |
2017-05-18 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Novel rna-based vector system for transient and stable gene expression
|
|
EP3374494A4
(en)
*
|
2015-11-11 |
2019-05-01 |
Coda Biotherapeutics, Inc. |
CRISPR COMPOSITIONS AND METHODS OF USE FOR GENE THERAPY
|
|
WO2017083852A1
(en)
|
2015-11-13 |
2017-05-18 |
MOORE, Tara |
Methods for the treatment of corneal dystrophies
|
|
SG11201804166YA
(en)
|
2015-11-16 |
2018-06-28 |
Res Inst Nationwide Childrens Hospital |
Materials and methods for treatment of titin-based myopathies and other titinopaties
|
|
CN106893739A
(zh)
|
2015-11-17 |
2017-06-27 |
香港中文大学 |
用于靶向基因操作的新方法和系统
|
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
|
GB201520497D0
(en)
|
2015-11-20 |
2016-01-06 |
4D Pharma Res Ltd |
Compositions comprising bacterial strains
|
|
EP3363446A1
(en)
|
2015-11-20 |
2018-08-22 |
4D Pharma Research Limited |
Compositions comprising bacterial strains
|
|
EP3380613B1
(en)
|
2015-11-23 |
2022-10-26 |
The Regents of the University of California |
Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9
|
|
US20210395799A1
(en)
*
|
2015-11-25 |
2021-12-23 |
Integrated Dna Technologies, Inc. |
Methods for variant detection
|
|
EP3380635A2
(en)
*
|
2015-11-25 |
2018-10-03 |
Integrated DNA Technologies Inc. |
Methods for variant detection
|
|
KR20250044471A
(ko)
|
2015-11-30 |
2025-03-31 |
듀크 유니버시티 |
유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
|
|
CN121294437A
(zh)
|
2015-12-04 |
2026-01-09 |
诺华股份有限公司 |
用于免疫肿瘤学的组合物和方法
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
CN105624191A
(zh)
*
|
2015-12-24 |
2016-06-01 |
江苏大学 |
一种建立cyp2d1基因敲除大鼠模型的方法
|
|
CN105624196A
(zh)
*
|
2015-12-24 |
2016-06-01 |
江苏大学 |
一种建立cyp2c11基因敲除大鼠模型的方法
|
|
WO2017114497A1
(en)
|
2015-12-30 |
2017-07-06 |
Novartis Ag |
Immune effector cell therapies with enhanced efficacy
|
|
CN105548420B
(zh)
*
|
2015-12-30 |
2019-08-02 |
上海泽润生物科技有限公司 |
Mops残留量的检测方法
|
|
MY194127A
(en)
|
2016-01-11 |
2022-11-14 |
Univ Leland Stanford Junior |
Chimeric proteins and methods of immunotherapy
|
|
EA201891619A1
(ru)
*
|
2016-01-11 |
2019-02-28 |
Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити |
Химерные белки и способы регулирования экспрессии генов
|
|
US10053693B2
(en)
|
2016-01-19 |
2018-08-21 |
Mubin I. Syed |
Method for controlling obesity using minimally invasive means
|
|
US20190264186A1
(en)
|
2016-01-22 |
2019-08-29 |
The Broad Institute Inc. |
Crystal structure of crispr cpf1
|
|
US11826433B2
(en)
|
2016-02-02 |
2023-11-28 |
University Of Massachusetts |
Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system
|
|
CA3012344A1
(en)
|
2016-02-12 |
2017-08-17 |
University Of Massachusetts |
Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
|
|
MX2018009904A
(es)
|
2016-02-15 |
2019-07-08 |
Univ Temple |
Escision de secuencias de acido nucleico retrovirales.
|
|
WO2017143071A1
(en)
|
2016-02-18 |
2017-08-24 |
The Regents Of The University Of California |
Methods and compositions for gene editing in stem cells
|
|
CN116763942A
(zh)
|
2016-02-18 |
2023-09-19 |
宾州研究基金会 |
脑内生成gaba能神经元
|
|
WO2017147196A1
(en)
|
2016-02-22 |
2017-08-31 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating immune phenotypes
|
|
US10286073B2
(en)
*
|
2016-02-23 |
2019-05-14 |
Ilisa Tech, Inc. |
Magnetic control of gene delivery in vivo
|
|
CN114908093A
(zh)
*
|
2016-02-26 |
2022-08-16 |
朗泽科技新西兰有限公司 |
用于c1固定菌的crispr/cas系统
|
|
CA3016571A1
(en)
|
2016-03-04 |
2017-09-08 |
Indoor Biotechnologies Inc. |
Fel d 1 knockouts and associated compositions and methods based on crispr-cas9 genomic editing
|
|
SG10201913557TA
(en)
|
2016-03-04 |
2020-02-27 |
4D Pharma Plc |
Compositions comprising bacterial blautia strains for treating visceral hypersensitivity
|
|
GB201612191D0
(en)
|
2016-07-13 |
2016-08-24 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
WO2017161043A1
(en)
|
2016-03-16 |
2017-09-21 |
The J. David Gladstone Institutes |
Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
WO2017161325A1
(en)
|
2016-03-17 |
2017-09-21 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
CN109196119A
(zh)
|
2016-03-29 |
2019-01-11 |
株式会社国际电气通信基础技术研究所 |
用以预防或治疗选自由肾功能减退、慢性肾病和肾衰竭组成的组中的至少一种疾病的活性组分的候选物质的筛选方法
|
|
CN114778845A
(zh)
|
2016-03-29 |
2022-07-22 |
无限生物制药公司 |
药物组合物或食品组合物及评价活性成分体内效果的方法
|
|
AU2017244143B2
(en)
*
|
2016-03-30 |
2024-06-20 |
Intellia Therapeutics, Inc. |
Lipid nanoparticle formulations for CRISPR/Cas components
|
|
WO2017176929A1
(en)
|
2016-04-05 |
2017-10-12 |
University Of Massachusetts |
Compositions and methods for selective inhibition of grainyhead-like protein expression
|
|
EP4047092B1
(en)
|
2016-04-13 |
2025-07-30 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
WO2017181105A1
(en)
|
2016-04-15 |
2017-10-19 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance
|
|
US11286478B2
(en)
|
2016-04-19 |
2022-03-29 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
WO2017189308A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
AU2017253089B2
(en)
|
2016-04-19 |
2023-07-20 |
Massachusetts Institute Of Technology |
Novel CRISPR enzymes and systems
|
|
CN116200465A
(zh)
|
2016-04-25 |
2023-06-02 |
哈佛学院董事及会员团体 |
用于原位分子检测的杂交链反应方法
|
|
WO2017189542A1
(en)
*
|
2016-04-26 |
2017-11-02 |
University Of Georgia Research Foundation, Inc. |
Plants having reduced methylation of cytosine nucleotides and methods of use
|
|
US11213594B2
(en)
|
2016-04-29 |
2022-01-04 |
Poseida Therapeutics, Inc. |
Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
US11085035B2
(en)
|
2016-05-03 |
2021-08-10 |
Flodesign Sonics, Inc. |
Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
|
|
WO2017192997A1
(en)
|
2016-05-05 |
2017-11-09 |
Children's Hospital Medical Center |
Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
|
|
JP7066635B2
(ja)
|
2016-05-18 |
2022-05-13 |
ボイジャー セラピューティクス インコーポレイテッド |
調節性ポリヌクレオチド
|
|
CN109475109B
(zh)
*
|
2016-05-20 |
2021-10-29 |
瑞泽恩制药公司 |
用于使用多个引导rna来破坏免疫耐受性的方法
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
WO2017218852A1
(en)
|
2016-06-15 |
2017-12-21 |
University Of Massachusetts |
Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
|
|
AU2017283713B2
(en)
|
2016-06-17 |
2021-04-08 |
Massachusetts Institute Of Technology |
Type VI CRISPR orthologs and systems
|
|
AU2017280353B2
(en)
|
2016-06-24 |
2021-11-11 |
Inscripta, Inc. |
Methods for generating barcoded combinatorial libraries
|
|
US11471462B2
(en)
|
2016-06-27 |
2022-10-18 |
The Broad Institute, Inc. |
Compositions and methods for detecting and treating diabetes
|
|
WO2018005873A1
(en)
|
2016-06-29 |
2018-01-04 |
The Broad Institute Inc. |
Crispr-cas systems having destabilization domain
|
|
ES2938210T3
(es)
|
2016-07-13 |
2023-04-05 |
Vertex Pharma |
Métodos, composiciones y kits para aumentar la eficiencia de edición del genoma
|
|
TWI802545B
(zh)
|
2016-07-13 |
2023-05-21 |
英商4D製藥有限公司 |
包含細菌菌株之組合物
|
|
US12214056B2
(en)
|
2016-07-19 |
2025-02-04 |
Duke University |
Therapeutic applications of CPF1-based genome editing
|
|
US11123409B2
(en)
*
|
2016-07-28 |
2021-09-21 |
Institute For Basic Science |
Method of treating or preventing eye disease using Cas9 protein and guide RNA
|
|
WO2018023014A1
(en)
|
2016-07-29 |
2018-02-01 |
Regeneron Pharmaceuticals, Inc. |
Mice comprising mutations resulting in expression of c-truncated fibrillin-1
|
|
US11566263B2
(en)
|
2016-08-02 |
2023-01-31 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290 associated disease
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
CA3032699A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harvard College |
Adenosine nucleobase editors and uses thereof
|
|
CA3033327A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
RU2767206C2
(ru)
*
|
2016-08-12 |
2022-03-16 |
Тулджен Инкорпорейтед |
Модифицированный иммунорегуляторный элемент и изменение иммунитета посредством этого элемента
|
|
US11630103B2
(en)
|
2016-08-17 |
2023-04-18 |
The Broad Institute, Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
US20200283743A1
(en)
*
|
2016-08-17 |
2020-09-10 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
EP4485466A3
(en)
|
2016-08-17 |
2025-04-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
WO2018035250A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
CA3034089A1
(en)
*
|
2016-08-18 |
2018-02-22 |
The Regents Of The University Of California |
Crispr-cas genome engineering via a modular aav delivery system
|
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
|
US20220056440A1
(en)
*
|
2016-08-20 |
2022-02-24 |
Tara Moore |
Crispr gene editing for autosomal dominant diseases
|
|
KR20230155013A
(ko)
|
2016-08-20 |
2023-11-09 |
아벨리노 랩 유에스에이, 인크. |
단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
EP3510145A4
(en)
|
2016-09-06 |
2020-03-25 |
The Children's Medical Center Corporation |
IMMUNCELLS FROM INDUCED PLURIPOTENT STEM CELLS
|
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
IL247752A0
(en)
|
2016-09-11 |
2016-11-30 |
Yeda Res & Dev |
Compositions and methods for modulating gene expression for site-directed mutagenesis
|
|
US12188059B2
(en)
|
2016-09-13 |
2025-01-07 |
The Broad Institute, Inc. |
Proximity-dependent biotinylation and uses thereof
|
|
US10457940B2
(en)
|
2016-09-22 |
2019-10-29 |
University Of Massachusetts |
AAV treatment of Huntington's disease
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
EP3516056B1
(en)
*
|
2016-09-23 |
2024-11-27 |
DSM IP Assets B.V. |
A guide-rna expression system for a host cell
|
|
WO2018064208A1
(en)
|
2016-09-28 |
2018-04-05 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
EP3523426A4
(en)
|
2016-09-30 |
2020-01-22 |
The Regents of The University of California |
RNA GUIDED NUCLEIC ACID MODIFYING ENZYMES AND METHOD FOR USE THEREOF
|
|
WO2018064352A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
CA3039409A1
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
JP7577291B6
(ja)
|
2016-10-13 |
2024-11-26 |
ユニバーシティ オブ マサチューセッツ |
Aavカプシド設計
|
|
US11306324B2
(en)
|
2016-10-14 |
2022-04-19 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
GB2604416B
(en)
|
2016-10-18 |
2023-03-15 |
Univ Minnesota |
Tumor infiltating lymphocytes and methods of therapy
|
|
WO2018083606A1
(en)
|
2016-11-01 |
2018-05-11 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
|
EP3534919A4
(en)
|
2016-11-04 |
2020-11-11 |
Children's Hospital Medical Center |
Liver organoid compositions and methods of making and using same
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
RU2022105597A
(ru)
|
2016-11-14 |
2022-04-04 |
Тулджен Инкорпорейтед |
Искусственно созданная система управления функцией шк
|
|
KR102807995B1
(ko)
|
2016-12-05 |
2025-05-16 |
칠드런즈 호스피탈 메디칼 센터 |
결장 유사장기 및 이를 제조 및 사용하는 방법
|
|
WO2018107103A1
(en)
|
2016-12-09 |
2018-06-14 |
The Broad Institute, Inc. |
Crispr-systems for modifying a trait of interest in a plant
|
|
SI3551753T1
(sl)
|
2016-12-09 |
2022-09-30 |
The Broad Institute, Inc. |
Diagnostika, temelječa na sistemu CRISPR EFFECTOR
|
|
GB201621123D0
(en)
|
2016-12-12 |
2017-01-25 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
KR20210035022A
(ko)
|
2016-12-14 |
2021-03-31 |
리간달 인코포레이티드 |
핵산 및/또는 단백질 적재물 전달을 위한 조성물 및 방법
|
|
US12286727B2
(en)
|
2016-12-19 |
2025-04-29 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
JP7456605B2
(ja)
*
|
2016-12-23 |
2024-03-27 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
Pcsk9の遺伝子編集
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
WO2018124005A1
(ja)
|
2016-12-27 |
2018-07-05 |
中外製薬株式会社 |
被験物質の免疫原性を評価する方法
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
CN106632693B
(zh)
*
|
2017-01-19 |
2021-05-25 |
上海科技大学 |
具有多个核定位序列的SpyCas9蛋白及其应用
|
|
JP7094963B2
(ja)
|
2017-01-23 |
2022-07-04 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Hsd17b13バリアントおよびその使用
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018147343A1
(en)
*
|
2017-02-07 |
2018-08-16 |
Edigene Corporation |
Method of treating diseases associated with elevated kras expression using crispr-gndm system
|
|
US20190367924A1
(en)
*
|
2017-02-17 |
2019-12-05 |
Temple University - Of The Commonwealth System Of Higher Education |
Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5
|
|
JP2020508685A
(ja)
*
|
2017-03-03 |
2020-03-26 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
サプレッサーtRNA及びデアミナーゼによる変異のRNAターゲティング
|
|
US10687520B2
(en)
|
2017-03-07 |
2020-06-23 |
The Board Of Regents Of The University Of Texas System |
Generation and correction of a humanized mouse model with a deletion of dystrophin exon 44
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
JP2020510038A
(ja)
|
2017-03-09 |
2020-04-02 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
がんワクチン
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
BR112019019087A2
(pt)
|
2017-03-15 |
2020-05-12 |
The Broad Institute, Inc. |
Diagnóstico baseado em sistema efetor de crispr para detecção de vírus
|
|
KR102454284B1
(ko)
|
2017-03-15 |
2022-10-12 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규 cas13b 오르소로그 crispr 효소 및 시스템
|
|
US11174515B2
(en)
|
2017-03-15 |
2021-11-16 |
The Broad Institute, Inc. |
CRISPR effector system based diagnostics
|
|
US11104937B2
(en)
|
2017-03-15 |
2021-08-31 |
The Broad Institute, Inc. |
CRISPR effector system based diagnostics
|
|
WO2018170515A1
(en)
|
2017-03-17 |
2018-09-20 |
The Broad Institute, Inc. |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
WO2018175502A2
(en)
*
|
2017-03-21 |
2018-09-27 |
Shuber Anthony P |
Treating cancer with cas endonuclease complexes
|
|
AU2018237159A1
(en)
*
|
2017-03-22 |
2019-09-05 |
Intellia Therapeutics, Inc. |
Compositions and methods for immunooncology
|
|
EP3601562A1
(en)
|
2017-03-23 |
2020-02-05 |
President and Fellows of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
US11913075B2
(en)
|
2017-04-01 |
2024-02-27 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
WO2018191520A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
BR112019021378A2
(pt)
|
2017-04-12 |
2020-05-05 |
Massachusetts Inst Technology |
ortólogos de crispr tipo vi inovadores e sistemas
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
US11618928B2
(en)
|
2017-04-12 |
2023-04-04 |
The Broad Institute, Inc. |
CRISPR effector system based diagnostics for malaria detection
|
|
US12350368B2
(en)
|
2017-04-14 |
2025-07-08 |
The Broad Institute, Inc. |
Delivery of large payloads
|
|
US12281334B2
(en)
|
2017-04-14 |
2025-04-22 |
Children's Hospital Medical Center |
Multi donor stem cell compositions and methods of making same
|
|
WO2018195129A1
(en)
|
2017-04-17 |
2018-10-25 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
|
WO2018195019A1
(en)
|
2017-04-18 |
2018-10-25 |
The Broad Institute Inc. |
Compositions for detecting secretion and methods of use
|
|
SG11201909797QA
(en)
|
2017-04-20 |
2019-11-28 |
Egenesis Inc |
Methods for generating genetically modified animals
|
|
WO2018195486A1
(en)
|
2017-04-21 |
2018-10-25 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
WO2018195545A2
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US11696954B2
(en)
*
|
2017-04-28 |
2023-07-11 |
Exicure Operating Company |
Synthesis of spherical nucleic acids using lipophilic moieties
|
|
EP3615672A1
(en)
|
2017-04-28 |
2020-03-04 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
|
US11072816B2
(en)
|
2017-05-03 |
2021-07-27 |
The Broad Institute, Inc. |
Single-cell proteomic assay using aptamers
|
|
EP3618839A4
(en)
|
2017-05-05 |
2021-06-09 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
KR102338993B1
(ko)
|
2017-05-08 |
2021-12-14 |
주식회사 툴젠 |
인위적으로 조작된 조작면역세포
|
|
US11859179B2
(en)
|
2017-05-09 |
2024-01-02 |
University Of Massachusetts |
Methods of treating amyotrophic lateral sclerosis (ALS)
|
|
WO2018208910A1
(en)
|
2017-05-09 |
2018-11-15 |
The Broad Institute Inc. |
Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
CA3062595A1
(en)
|
2017-05-10 |
2018-11-15 |
The Regents Of The University Of California |
Directed editing of cellular rna via nuclear delivery of crispr/cas9
|
|
US12226479B2
(en)
|
2017-05-11 |
2025-02-18 |
The General Hospital Corporation |
Methods and compositions of use of CD8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
EP3622091A4
(en)
*
|
2017-05-12 |
2021-02-17 |
President and Fellows of Harvard College |
UNIVERSAL EARLY CANCER DIAGNOSIS
|
|
WO2018213459A1
(en)
*
|
2017-05-16 |
2018-11-22 |
Wisconsin Alumni Research Foundation |
System and method for en masse patterning of molecule structures
|
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
EP3625343B1
(en)
|
2017-05-18 |
2025-09-10 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
MA48941A
(fr)
|
2017-05-22 |
2020-04-08 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
TW201907931A
(zh)
|
2017-05-24 |
2019-03-01 |
英商4D製藥研究有限公司 |
包含細菌菌株之組合物
|
|
AU2018273986A1
(en)
|
2017-05-25 |
2019-12-12 |
The General Hospital Corporation |
Bipartite base editor (BBE) architectures and type-II-C-Cas9 zinc finger editing
|
|
CA3102054A1
(en)
|
2017-06-05 |
2018-12-13 |
Fred Hutchinson Cancer Research Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
|
WO2018227114A1
(en)
|
2017-06-09 |
2018-12-13 |
Editas Medicine, Inc. |
Engineered cas9 nucleases
|
|
US11897953B2
(en)
|
2017-06-14 |
2024-02-13 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
SMT202200272T1
(it)
|
2017-06-14 |
2022-07-21 |
4D Pharma Res Limited |
Composizioni comprendenti ceppi batterici
|
|
RS61210B1
(sr)
|
2017-06-14 |
2021-01-29 |
4D Pharma Res Ltd |
Kompozicije koje sadrže bakterijske sojeve
|
|
BR112019026477A2
(pt)
|
2017-06-14 |
2020-07-14 |
4D Pharma Research Limited |
composições compreendendo cepas bacterianas
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
IL271516B2
(en)
|
2017-06-23 |
2024-10-01 |
Univ Kentucky Res Found |
A method for modulating the alkaloid content of a plant, a method for producing a plant and a modified plant
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
CA3064601A1
(en)
|
2017-06-26 |
2019-01-03 |
The Broad Institute, Inc. |
Crispr/cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
BR112019027692A2
(pt)
*
|
2017-06-28 |
2020-11-24 |
University Of South Florida |
gene ube3a modificado para uma abordagem terapêutica genética para a síndrome de angelman
|
|
JP2020530307A
(ja)
|
2017-06-30 |
2020-10-22 |
インティマ・バイオサイエンス,インコーポレーテッド |
遺伝子治療のためのアデノ随伴ウイルスベクター
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
WO2019003193A1
(en)
|
2017-06-30 |
2019-01-03 |
Novartis Ag |
METHODS FOR TREATING DISEASES USING GENE EDITING SYSTEMS
|
|
WO2019010422A1
(en)
|
2017-07-07 |
2019-01-10 |
The Broad Institute, Inc. |
ANTIVIRAL THERAPY BASED ON THE CRISPR SYSTEM
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
WO2019018440A1
(en)
|
2017-07-17 |
2019-01-24 |
The Broad Institute, Inc. |
HUMAN COLON CELL ATLAS IN GOOD HEALTH AND WITH HEMORRHAGIC RECTO-COLITIS
|
|
JP7210028B2
(ja)
*
|
2017-07-18 |
2023-01-23 |
国立大学法人京都大学 |
遺伝子変異導入方法
|
|
WO2019018694A1
(en)
|
2017-07-19 |
2019-01-24 |
Dana-Farber Cancer Institute, Inc. |
DIAGNOSIS AND TREATMENT OF CANCER
|
|
JP2020534795A
(ja)
|
2017-07-28 |
2020-12-03 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
|
|
JP2020533957A
(ja)
|
2017-07-31 |
2020-11-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
Crisprリポーター非ヒト動物およびその使用
|
|
EP3585159B1
(en)
*
|
2017-07-31 |
2025-05-14 |
Regeneron Pharmaceuticals, Inc. |
Method of testing the ability of a crispr/cas9 nuclease to modify a target genomic locus in vivo, by making use of a cas-transgenic mouse or rat which comprises a cas9 expression cassette in its genome
|
|
KR20200032117A
(ko)
|
2017-07-31 |
2020-03-25 |
리제너론 파마슈티칼스 인코포레이티드 |
생체 내에서 외인성 공여체 핵산과의 CRISPR/Cas-유도된 재조합의 평가
|
|
BR102017016440A2
(pt)
|
2017-07-31 |
2019-03-19 |
Universidade Federal Do Rio Grande Do Sul |
Composição para terapia gênica do sistema nervoso central, processo de obtenção e uso da mesma
|
|
WO2019040650A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES HAVING MODIFIED PAM SPECIFICITY
|
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
|
US20190083457A1
(en)
*
|
2017-09-15 |
2019-03-21 |
The Borad Of Trustees Of The Leland Stanford Junior University |
Mitochondrial aldehyde dehydrogenase-2 modulators for protecting, expanding and increasing the potency of hematopoietic stem cells
|
|
AU2018338318B2
(en)
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11739330B2
(en)
|
2017-09-22 |
2023-08-29 |
University Of Massachusetts |
SOD1 dual expression vectors and uses thereof
|
|
AU2018341349A1
(en)
*
|
2017-09-27 |
2020-04-09 |
E. I. Du Pont De Nemours And Company |
Soil application of crop protection agents
|
|
US12295978B2
(en)
*
|
2017-09-28 |
2025-05-13 |
Shiftbio Inc. |
Recombinant plasma membrane-based vesicle, for treating cancer
|
|
KR102544051B1
(ko)
|
2017-09-29 |
2023-06-16 |
리제너론 파마슈티칼스 인코포레이티드 |
인간화된 ttr 유전자좌를 포함하는 비인간 동물 및 사용 방법
|
|
IL311170A
(en)
|
2017-09-29 |
2024-04-01 |
Intellia Therapeutics Inc |
Compositions and methods for ttr gene editing and treating attr amyloidosis
|
|
EP3695408A4
(en)
|
2017-10-02 |
2021-12-15 |
The Broad Institute, Inc. |
PROCEDURES AND COMPOSITIONS FOR DETECTION AND MODULATION OF IMMUNOTHERAPY RESISTANT GENE SIGNATURE IN CANCER
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
JP2020537516A
(ja)
|
2017-10-04 |
2020-12-24 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
標的化された核酸編集のためのシステム、方法、及び組成物
|
|
KR102628577B1
(ko)
|
2017-10-04 |
2024-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
Crispr 이펙터 시스템 기반 진단법
|
|
CA3077442A1
(en)
|
2017-10-10 |
2019-04-18 |
Children's Hospital Medical Center |
Esophageal tissue and/or organoid compositions and methods of making same
|
|
US11725228B2
(en)
|
2017-10-11 |
2023-08-15 |
The General Hospital Corporation |
Methods for detecting site-specific and spurious genomic deamination induced by base editing technologies
|
|
JP2021500036A
(ja)
|
2017-10-16 |
2021-01-07 |
ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. |
アデノシン塩基編集因子の使用
|
|
WO2019079362A1
(en)
|
2017-10-16 |
2019-04-25 |
Massachusetts Institute Of Technology |
HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS
|
|
WO2019079772A1
(en)
|
2017-10-20 |
2019-04-25 |
Fred Hutchinson Cancer Research Center |
SYSTEMS AND METHODS FOR GENETICALLY MODIFIED B-LYMPHOCYTES FOR EXPRESSING SELECTED ANTIBODIES
|
|
US12227742B2
(en)
|
2017-10-23 |
2025-02-18 |
The Broad Institute, Inc. |
Nucleic acid modifiers
|
|
US11547614B2
(en)
|
2017-10-31 |
2023-01-10 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
US12227753B2
(en)
|
2017-11-01 |
2025-02-18 |
The Regents Of The University Of California |
CasY compositions and methods of use
|
|
US20210180053A1
(en)
|
2017-11-01 |
2021-06-17 |
Novartis Ag |
Synthetic rnas and methods of use
|
|
WO2019090174A1
(en)
|
2017-11-02 |
2019-05-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
WO2019094984A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
US12018080B2
(en)
|
2017-11-13 |
2024-06-25 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway
|
|
EP3710583A1
(en)
|
2017-11-16 |
2020-09-23 |
Astrazeneca AB |
Compositions and methods for improving the efficacy of cas9-based knock-in strategies
|
|
US12458411B2
(en)
|
2017-12-07 |
2025-11-04 |
Augmedics Ltd. |
Spinous process clamp
|
|
US11332736B2
(en)
|
2017-12-07 |
2022-05-17 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
BR112020009889A2
(pt)
|
2017-12-14 |
2020-11-03 |
Flodesign Sonics, Inc. |
acionador e controlador de transdutor acústico
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019126626A1
(en)
|
2017-12-21 |
2019-06-27 |
Children's Hospital Medical Center |
Digitalized human organoids and methods of using same
|
|
EP3728575A4
(en)
|
2017-12-22 |
2021-11-24 |
The Broad Institute, Inc. |
CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF DNA BASES
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
EP3737690A1
(en)
|
2018-01-12 |
2020-11-18 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
WO2019143675A1
(en)
|
2018-01-17 |
2019-07-25 |
Vertex Pharmaceuticals Incorporated |
Dna-pk inhibitors
|
|
JP7483612B2
(ja)
|
2018-01-17 |
2024-05-15 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ゲノム編集効率を増加するためのキノキサリノン化合物、組成物、方法、およびキット
|
|
US12005127B2
(en)
|
2018-01-17 |
2024-06-11 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
|
EP3740580A4
(en)
|
2018-01-19 |
2021-10-20 |
Duke University |
GENOMIC ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYOTES
|
|
KR102857066B1
(ko)
|
2018-01-29 |
2025-09-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
Crispr 이펙터 시스템 기반 진단
|
|
SG11202006722RA
(en)
|
2018-01-31 |
2020-08-28 |
Res Inst Nationwide Childrens Hospital |
Gene therapy for limb-girdle muscular dystrophy type 2c
|
|
CA3087869A1
(en)
*
|
2018-02-02 |
2019-08-08 |
The Penn State Research Foundation |
Methods and materials for treating brain injuries
|
|
WO2019157304A1
(en)
*
|
2018-02-09 |
2019-08-15 |
Empirico Inc. |
Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions
|
|
US20210032612A1
(en)
*
|
2018-02-22 |
2021-02-04 |
Avellino Lab Usa, Inc. |
CRISPR/Cas9 Systems, and Methods of Use Thereof
|
|
WO2019165168A1
(en)
|
2018-02-23 |
2019-08-29 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 orthologs
|
|
EP3758714A4
(en)
*
|
2018-02-27 |
2021-12-01 |
The University of North Carolina at Chapel Hill |
METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN'S SYNDROME
|
|
EP3765616B1
(en)
|
2018-03-14 |
2023-07-19 |
Arbor Biotechnologies, Inc. |
Novel crispr dna and rna targeting enzymes and systems
|
|
CN112041444A
(zh)
|
2018-03-14 |
2020-12-04 |
阿伯生物技术公司 |
新型crispr dna靶向酶及系统
|
|
SG11202008956XA
(en)
|
2018-03-14 |
2020-10-29 |
Editas Medicine Inc |
Systems and methods for the treatment of hemoglobinopathies
|
|
KR101889683B1
(ko)
*
|
2018-03-14 |
2018-08-17 |
유병탁 |
철골 구조 시공 방법
|
|
BR112020018658A2
(pt)
|
2018-03-15 |
2020-12-29 |
KSQ Therapeutics, Inc. |
Composições de regulação gênica e métodos para imu-noterapia aprimorada
|
|
EP3592140A1
(en)
|
2018-03-19 |
2020-01-15 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems
|
|
EP3768327A4
(en)
*
|
2018-03-23 |
2022-04-13 |
The Trustees of Columbia University in the City of New York |
GENE EDITING FOR AUTOSOMAL DOMINANT DISEASES
|
|
CA3096274A1
(en)
|
2018-04-06 |
2019-10-10 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
|
US11898203B2
(en)
|
2018-04-17 |
2024-02-13 |
The General Hospital Corporation |
Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents
|
|
WO2019204585A1
(en)
|
2018-04-19 |
2019-10-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
|
ES2922902T3
(es)
|
2018-04-24 |
2022-09-21 |
Kws Saat Se & Co Kgaa |
Plantas con digestibilidad mejorada y haplotipos marcadores
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
WO2019213065A1
(en)
*
|
2018-04-30 |
2019-11-07 |
Oregon Health & Science University |
Methods of gene therapy
|
|
EP3787543A4
(en)
|
2018-05-02 |
2022-01-19 |
Augmedics Ltd. |
REGISTRATION OF A FIDUCIAL MARKER FOR AN AUGMENTED REALITY SYSTEM
|
|
CN112512595A
(zh)
*
|
2018-05-03 |
2021-03-16 |
哈佛学院校长同事会 |
心脏、骨骼肌和肌肉干细胞中的体内同源性定向修复
|
|
WO2019213660A2
(en)
|
2018-05-04 |
2019-11-07 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
CA3100019A1
(en)
|
2018-05-11 |
2019-11-14 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
JP2021523914A
(ja)
|
2018-05-15 |
2021-09-09 |
ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. |
パーキンソン病を治療するための組成物および方法
|
|
KR20210045360A
(ko)
|
2018-05-16 |
2021-04-26 |
신테고 코포레이션 |
가이드 rna 설계 및 사용을 위한 방법 및 시스템
|
|
WO2019222555A1
(en)
|
2018-05-16 |
2019-11-21 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated systems and components
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CN108707628B
(zh)
*
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
|
US20210371932A1
(en)
|
2018-06-01 |
2021-12-02 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US12163129B2
(en)
|
2018-06-08 |
2024-12-10 |
University Of Massachusetts |
Antisense oligonucleotides to restore dysferlin protein expression in dysferlinopathy patient cells
|
|
GB201809588D0
(en)
*
|
2018-06-12 |
2018-07-25 |
Univ Bristol |
Materials and methods for modulating intraocular and intracranial pressure
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
CN112368396A
(zh)
|
2018-06-26 |
2021-02-12 |
博德研究所 |
基于crispr/cas和转座酶的扩增组合物、系统和方法
|
|
BR112020026246A2
(pt)
|
2018-06-26 |
2021-04-20 |
The Broad Institute Inc. |
composições, sistemas e métodos de amplificação com base em nickase dupla crispr
|
|
KR20210040943A
(ko)
|
2018-06-26 |
2021-04-14 |
매사추세츠 인스티튜트 오브 테크놀로지 |
Crispr 이펙터 시스템 기반 증폭 방법, 시스템, 및 진단
|
|
US11629179B2
(en)
|
2018-06-29 |
2023-04-18 |
Stichting Het Nederlands Kanker Instituut—Antoni van Leeuwenhoek Ziekenhuis |
TWEAK-receptor agonists for use in combination with immunotherapy of a cancer
|
|
CA3104856A1
(en)
|
2018-06-29 |
2020-01-02 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
EP3814514A1
(en)
|
2018-06-29 |
2021-05-05 |
Research Institute at Nationwide Children's Hospital |
Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2a
|
|
CN112513270B
(zh)
|
2018-07-13 |
2025-02-25 |
加利福尼亚大学董事会 |
基于逆转录转座子的递送媒介物及其使用方法
|
|
US20210284981A1
(en)
*
|
2018-07-24 |
2021-09-16 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
SG11202100533VA
(en)
|
2018-07-26 |
2021-02-25 |
Childrens Hospital Med Ct |
Hepato-biliary-pancreatic tissues and methods of making same
|
|
AU2019314433A1
(en)
|
2018-07-31 |
2021-03-25 |
Massachusetts Institute Of Technology |
Novel CRISPR enzymes and systems
|
|
GB201812603D0
(en)
|
2018-08-02 |
2018-09-19 |
British American Tobacco Investments Ltd |
Method
|
|
JP2021532815A
(ja)
|
2018-08-07 |
2021-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新規Cas12b酵素およびシステム
|
|
KR102158428B1
(ko)
*
|
2018-08-16 |
2020-09-22 |
(주)라트바이오 |
인위적 뉴클레아제를 생산하는 형질전환 배아 및 형질전환 동물의 제작 방법
|
|
US12486519B2
(en)
|
2018-08-18 |
2025-12-02 |
President And Fellows Of Harvard College |
In situ gene editing
|
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
|
WO2020041387A1
(en)
|
2018-08-20 |
2020-02-27 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
US12460244B2
(en)
|
2018-08-20 |
2025-11-04 |
The Broad Institute, Inc. |
Inhibitors of RNA-guided nuclease activity and uses thereof
|
|
US12391685B2
(en)
|
2018-08-20 |
2025-08-19 |
The Broad Institute, Inc. |
Inhibitors of RNA-guided nuclease target binding and uses thereof
|
|
EP3841205A4
(en)
|
2018-08-22 |
2022-08-17 |
The Regents of The University of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
EP3847650A1
(en)
|
2018-09-06 |
2021-07-14 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
WO2020056158A1
(en)
|
2018-09-12 |
2020-03-19 |
Children's Hospital Medical Center |
Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
|
|
EP4268831A3
(en)
|
2018-09-12 |
2024-05-22 |
Fred Hutchinson Cancer Center |
Reducing cd33 expression to selectively protect therapeutic cells
|
|
EP3852813A4
(en)
|
2018-09-18 |
2022-06-22 |
VNV Newco Inc. |
ARC-BASED CAPSIDS AND THEIR USES
|
|
WO2020072816A1
(en)
|
2018-10-03 |
2020-04-09 |
The Broad Institute, Inc. |
Crispr effector system based diagnostics for hemorrhagic fever detection
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
WO2020077135A1
(en)
|
2018-10-10 |
2020-04-16 |
Dana-Farber Cancer Institute, Inc. |
Modulating resistance to bcl-2 inhibitors
|
|
WO2020077236A1
(en)
|
2018-10-12 |
2020-04-16 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
|
CN109295081B
(zh)
*
|
2018-10-17 |
2020-06-12 |
中国人民解放军第四军医大学 |
一种LDLR-Lamp2b融合基因、表达载体及其应用
|
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
WO2020092057A1
(en)
|
2018-10-30 |
2020-05-07 |
Yale University |
Compositions and methods for rapid and modular generation of chimeric antigen receptor t cells
|
|
WO2020092163A1
(en)
|
2018-11-01 |
2020-05-07 |
E. I. Du Pont De Nemours And Company |
Systems and methods for manufacture of controlled release of agricultural cores
|
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
GB201817971D0
(en)
|
2018-11-02 |
2018-12-19 |
British American Tobacco Investments Ltd |
Method
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
US12460189B2
(en)
|
2018-11-09 |
2025-11-04 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
CN111172194B
(zh)
*
|
2018-11-13 |
2024-04-19 |
四川横竖生物科技股份有限公司 |
基于hNPY与hAgRP基因过表达嵌合动物模型构建方法及应用
|
|
US20220073987A1
(en)
|
2018-11-14 |
2022-03-10 |
The Broad Institute, Inc. |
Crispr system based droplet diagnostic systems and methods
|
|
CN113302312A
(zh)
|
2018-11-14 |
2021-08-24 |
博德研究所 |
使用sherlock检测方法对高度进化的病毒变体进行多重化
|
|
GB201818715D0
(en)
|
2018-11-16 |
2019-01-02 |
British American Tobacco Investments Ltd |
Method
|
|
US11766296B2
(en)
|
2018-11-26 |
2023-09-26 |
Augmedics Ltd. |
Tracking system for image-guided surgery
|
|
US12258594B2
(en)
|
2018-12-05 |
2025-03-25 |
The Broad Institute, Inc. |
Cas proteins with reduced immunogenicity and methods of screening thereof
|
|
CN119193710A
(zh)
*
|
2018-12-05 |
2024-12-27 |
弗莱德哈钦森癌症中心 |
遗传修饰细胞的减少和最少的操作制造
|
|
IL314386A
(en)
*
|
2018-12-05 |
2024-09-01 |
Intellia Therapeutics Inc |
amine modified lipids
|
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
|
US20250043366A1
(en)
|
2018-12-13 |
2025-02-06 |
The Broad Institute, Inc. |
Tiled assays using crispr-cas based detection
|
|
BR112021011372A2
(pt)
|
2018-12-14 |
2021-08-31 |
Pioneer Hi-Bred International, Inc. |
Novos sistemas crispr-cas para edição de genoma
|
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
US12264323B2
(en)
|
2018-12-17 |
2025-04-01 |
The Broad Institute, Inc. |
CRISPR CPF1 direct repeat variants
|
|
CN113544266A
(zh)
|
2018-12-17 |
2021-10-22 |
博德研究所 |
Crispr相关转座酶系统和其使用方法
|
|
CN113423831B
(zh)
|
2018-12-20 |
2023-03-10 |
瑞泽恩制药公司 |
核酸酶介导的重复扩增
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
WO2020146276A2
(en)
*
|
2019-01-07 |
2020-07-16 |
Emendobio Inc. |
Crispr compostions and methods for promoting gene editing of adenosine deaminase 2 (ada2)
|
|
EP3911632A1
(en)
|
2019-01-15 |
2021-11-24 |
Empirico Inc. |
Prodrugs of alox-15 inhibitors and methods of using the same
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
GB201900940D0
(en)
|
2019-01-23 |
2019-03-13 |
British American Tobacco Investments Ltd |
Method
|
|
US20220119871A1
(en)
|
2019-01-28 |
2022-04-21 |
The Broad Institute, Inc. |
In-situ spatial transcriptomics
|
|
US11965159B2
(en)
|
2019-01-29 |
2024-04-23 |
The Broad Institute, Inc. |
Compositions and methods for regulating proteins and nucleic acids activities
|
|
EP3921417A4
(en)
|
2019-02-04 |
2022-11-09 |
The General Hospital Corporation |
VARIANTS OF ADENINE DNA BASES WITH REDUCED OFF-TARGET RNA EDIT
|
|
WO2020163856A1
(en)
|
2019-02-10 |
2020-08-13 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Modified mitochondrion and methods of use thereof
|
|
CA3128881A1
(en)
*
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Splice acceptor site disruption of a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
CA3236512A1
(en)
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Compositions and methods for treating hemoglobinopathies
|
|
US20230053540A1
(en)
|
2019-02-19 |
2023-02-23 |
Massachusetts Institute Of Technology |
Treatment of liver injury
|
|
US12377170B2
(en)
|
2019-02-26 |
2025-08-05 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of β-sarcoglycan and the treatment of muscular dystrophy
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
WO2020181101A1
(en)
|
2019-03-07 |
2020-09-10 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
WO2020186101A1
(en)
|
2019-03-12 |
2020-09-17 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
US20220154158A1
(en)
|
2019-03-12 |
2022-05-19 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Cas9 variants with enhanced specificity
|
|
US12419915B2
(en)
|
2019-03-13 |
2025-09-23 |
The Broad Institute, Inc. |
Microglial progenitors for regeneration of functional microglia in the central nervous system and therapeutics uses thereof
|
|
WO2020186231A2
(en)
|
2019-03-14 |
2020-09-17 |
The Broad Institute, Inc. |
Crispr effector system based multiplex diagnostics
|
|
US20220143148A1
(en)
|
2019-03-14 |
2022-05-12 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells
|
|
WO2020186223A1
(en)
|
2019-03-14 |
2020-09-17 |
The Broad Institute, Inc. |
Sherlock assays for tick-borne diseases
|
|
WO2020186213A1
(en)
|
2019-03-14 |
2020-09-17 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US20220177863A1
(en)
|
2019-03-18 |
2022-06-09 |
The Broad Institute, Inc. |
Type vii crispr proteins and systems
|
|
EP3942023A1
(en)
|
2019-03-18 |
2022-01-26 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
|
CN113711046B
(zh)
|
2019-03-18 |
2023-08-29 |
瑞泽恩制药公司 |
用于揭示与Tau聚集相关的基因脆弱性的CRISPR/Cas脱落筛选平台
|
|
US11845931B2
(en)
|
2019-03-18 |
2023-12-19 |
Regeneron Pharmaceuticals, Inc. |
CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
|
US20220152148A1
(en)
|
2019-03-18 |
2022-05-19 |
The Broad Institute, Inc. |
Modulation of type 2 immunity by targeting clec-2 signaling
|
|
KR20210143230A
(ko)
|
2019-03-19 |
2021-11-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
뉴클레오티드 서열을 편집하기 위한 방법 및 조성물
|
|
CN111733225A
(zh)
*
|
2019-03-25 |
2020-10-02 |
北京大学第一医院 |
一种可用于辅助氯吡格雷精准用药的prkg1基因snp标志物
|
|
EP3947687A1
(en)
|
2019-03-29 |
2022-02-09 |
Massachusetts Institute of Technology |
Constructs for continuous monitoring of live cells
|
|
US20220162649A1
(en)
|
2019-04-01 |
2022-05-26 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
WO2020206046A1
(en)
|
2019-04-01 |
2020-10-08 |
The Broad Institute, Inc. |
Methods and compositions for cell therapy
|
|
MX2021011956A
(es)
|
2019-04-03 |
2021-12-15 |
Regeneron Pharma |
Metodos y composiciones para la insercion de secuencias codificantes de anticuerpos en un locus de puerto seguro.
|
|
IL286917B
(en)
|
2019-04-04 |
2022-09-01 |
Regeneron Pharma |
Methods for scar-free insertion of targeted modifications into targeted vectors
|
|
IL286905B2
(en)
|
2019-04-04 |
2024-06-01 |
Regeneron Pharma |
Non-human animals containing the human coagulation factor 12 locus
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2020223539A1
(en)
|
2019-04-30 |
2020-11-05 |
The Broad Institute, Inc. |
Methods and compositions for barcoding nucleic acid libraries and cell populations
|
|
CA3139581A1
(en)
*
|
2019-05-03 |
2020-11-12 |
Specific Biologics Inc. |
Lipid-encapsulated dual-cleaving endonuclease for dna and gene editing
|
|
WO2020231702A1
(en)
*
|
2019-05-11 |
2020-11-19 |
Youngsuk Yi |
Compositions and methods containing exosomes
|
|
CN114096684B
(zh)
|
2019-05-13 |
2024-11-19 |
科沃施种子欧洲股份两合公司 |
玉米的耐旱性
|
|
GB201906768D0
(en)
|
2019-05-14 |
2019-06-26 |
British American Tobacco Investments Ltd |
Method
|
|
US20220249701A1
(en)
|
2019-05-14 |
2022-08-11 |
The Broad Institute, Inc. |
Compositions and methods for targeting multinucleated cells
|
|
WO2020236967A1
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Random crispr-cas deletion mutant
|
|
US20220220469A1
(en)
|
2019-05-20 |
2022-07-14 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
US20220233654A1
(en)
*
|
2019-05-21 |
2022-07-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Expression vector for cholesterol 24-hydrolase in therapy of rett syndrome
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
WO2020243371A1
(en)
|
2019-05-28 |
2020-12-03 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
US20220243178A1
(en)
|
2019-05-31 |
2022-08-04 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
CA3141807A1
(en)
|
2019-05-31 |
2020-12-03 |
Children's Hospital Medical Center |
Methods of generating and expanding hematopoietic stem cells
|
|
AU2020286382A1
(en)
|
2019-06-04 |
2021-11-04 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized TTR locus with a beta-slip mutation and methods of use
|
|
TW202112229A
(zh)
|
2019-06-07 |
2021-04-01 |
美商雷傑納榮製藥公司 |
包含人化白蛋白基因座之非人的動物
|
|
US12188045B2
(en)
|
2019-06-07 |
2025-01-07 |
KSQ Therapeutics, Inc. |
Guide RNA combinations and methods of use
|
|
JP7664854B2
(ja)
|
2019-06-14 |
2025-04-18 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
タウオパチーのモデル
|
|
WO2020257514A1
(en)
*
|
2019-06-21 |
2020-12-24 |
Children's Medical Center Corporation |
Methods and compositions for allele specific gene editing
|
|
BR112021026832A2
(pt)
|
2019-07-02 |
2022-05-10 |
Hutchinson Fred Cancer Res |
Vetores ad35 recombinantes e aprimoramentos da terapia gênica relacionada
|
|
GB201909563D0
(en)
|
2019-07-03 |
2019-08-14 |
British American Tobacco Investments Ltd |
Method
|
|
GB201909562D0
(en)
|
2019-07-03 |
2019-08-14 |
British American Tobacco Investments Ltd |
Method
|
|
US11980506B2
(en)
|
2019-07-29 |
2024-05-14 |
Augmedics Ltd. |
Fiducial marker
|
|
US12178666B2
(en)
|
2019-07-29 |
2024-12-31 |
Augmedics Ltd. |
Fiducial marker
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
US20220282333A1
(en)
|
2019-08-13 |
2022-09-08 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
DK4017871T5
(da)
|
2019-08-21 |
2024-08-05 |
Res Inst Nationwide Childrens Hospital |
Adenoassocieret virusvektoradministration af alfa-sarcoglycan og behandling af muskeldystrofi
|
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
WO2021046257A1
(en)
|
2019-09-03 |
2021-03-11 |
The Broad Institute, Inc. |
Crispr effector system based multiplex cancer diagnostics
|
|
US20220325296A1
(en)
|
2019-09-12 |
2022-10-13 |
The Broad Institute, Inc. |
Engineered adeno-associated virus capsids
|
|
KR20220062079A
(ko)
|
2019-09-13 |
2022-05-13 |
리제너론 파마슈티칼스 인코포레이티드 |
지질 나노입자에 의해 전달되는 CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
|
|
US12264367B2
(en)
|
2019-09-19 |
2025-04-01 |
The Broad Institute, Inc. |
Methods of in vivo evaluation of gene function
|
|
AU2020348872A1
(en)
|
2019-09-20 |
2022-04-14 |
Massachusetts Institute Of Technology |
Compositions and methods for delivering cargo to a target cell
|
|
US20230025039A1
(en)
|
2019-09-20 |
2023-01-26 |
The Broad Institute, Inc. |
Novel type vi crispr enzymes and systems
|
|
GB201913974D0
(en)
*
|
2019-09-27 |
2019-11-13 |
King S College London |
Vector
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CN115175991A
(zh)
|
2019-10-16 |
2022-10-11 |
博德研究所 |
工程化肌肉靶向组合物
|
|
AU2020366566A1
(en)
|
2019-10-17 |
2022-04-21 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
BR112022008861A2
(pt)
|
2019-11-08 |
2022-08-23 |
Regeneron Pharma |
Construto de ácido nucleico, vetor, nanopartícula lipídica, célula, composição para uso na expressão de retinosquisina, método para integrar uma sequência de codificação, e, método para modificar um gene rs1
|
|
US12195723B2
(en)
|
2019-11-08 |
2025-01-14 |
The Broad Institute, Inc. |
Engineered antigen presenting cells and uses thereof
|
|
CN110684801A
(zh)
*
|
2019-11-13 |
2020-01-14 |
武汉华美生物工程有限公司 |
转导cas9基因到哺乳动物细胞进行基因编辑的方法
|
|
AU2020388387A1
(en)
|
2019-11-22 |
2022-06-02 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
US12241830B2
(en)
|
2019-12-06 |
2025-03-04 |
Broad Institute, Inc. |
Living biosensors
|
|
EP3835309A1
(en)
|
2019-12-13 |
2021-06-16 |
KWS SAAT SE & Co. KGaA |
Method for increasing cold or frost tolerance in a plant
|
|
US11382712B2
(en)
|
2019-12-22 |
2022-07-12 |
Augmedics Ltd. |
Mirroring in image guided surgery
|
|
EP4081533A4
(en)
*
|
2019-12-23 |
2024-03-20 |
The Regents of The University of California |
CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHOD OF USE THEREOF
|
|
US20230340537A1
(en)
|
2020-01-17 |
2023-10-26 |
The Broad Institute, Inc. |
Small type ii-d cas proteins and methods of use thereof
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
US20230073449A1
(en)
|
2020-01-23 |
2023-03-09 |
The Children's Medical Center Corporation |
Stroma-free t cell differentiation from human pluripotent stem cells
|
|
EP4093864A4
(en)
|
2020-01-24 |
2024-04-10 |
The General Hospital Corporation |
Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants
|
|
EP4093863A4
(en)
|
2020-01-24 |
2024-04-10 |
The General Hospital Corporation |
CRISPR-CAS ENZYMES WITH ENHANCED ON-TARGET ACTIVITY
|
|
CN113281130B
(zh)
*
|
2020-02-20 |
2024-08-23 |
中国科学院上海高等研究院 |
一种用于大尺寸脑组织的高效的高尔基染色方法
|
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
|
MX2022010666A
(es)
|
2020-02-28 |
2023-01-30 |
Huigene Therapeutics Co Ltd |
Sistema crispr-cas de tipo vi-e y de tipo vi-f y usos del mismo.
|
|
CN115485385A
(zh)
|
2020-03-04 |
2022-12-16 |
瑞泽恩制药公司 |
用于使肿瘤细胞对免疫疗法敏感的方法和组合物
|
|
CN111321150B
(zh)
*
|
2020-03-13 |
2020-12-04 |
广西壮族自治区水产科学研究院 |
一种LvCTL4基因及编码的蛋白质、蛋白质的获取方法、表达载体、重组菌和应用
|
|
US20220228150A1
(en)
|
2020-03-17 |
2022-07-21 |
Gowtham THAKKU |
Crispr system high throughput diagnostic systems and methods
|
|
US11453907B2
(en)
|
2020-03-23 |
2022-09-27 |
The Broad Institute, Inc. |
Crispr effector system based coronavirus diagnostics
|
|
EP4125348A1
(en)
|
2020-03-23 |
2023-02-08 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
CA3177749A1
(en)
|
2020-03-31 |
2021-10-07 |
Arbor Biotechnologies, Inc. |
Compositions comprising a cas12i2 variant polypeptide and uses thereof
|
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
JP2023521055A
(ja)
|
2020-04-09 |
2023-05-23 |
アール・ジエイ・レイノルズ・タバコ・カンパニー |
ニコチアナ・タバカムにおけるニコチンレベルの調整方法
|
|
US20230121577A1
(en)
*
|
2020-04-15 |
2023-04-20 |
The Regents Of The University Of California |
Compositions and Methods for Treatment
|
|
US20230165909A1
(en)
|
2020-04-21 |
2023-06-01 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
|
US20250263752A1
(en)
|
2020-04-21 |
2025-08-21 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
|
EP4146797A1
(en)
|
2020-05-06 |
2023-03-15 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
|
BR112022022603A2
(pt)
|
2020-05-08 |
2023-01-17 |
Broad Inst Inc |
Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla
|
|
CA3178591A1
(en)
*
|
2020-05-12 |
2021-11-18 |
Courtney Young |
Immunosuppressive agents and viral delivery re-dosing methods for gene therapy
|
|
CN111521826A
(zh)
*
|
2020-05-21 |
2020-08-11 |
江海松 |
外周血外泌体中Notch3蛋白作为分子标记的应用及一种检测试剂盒
|
|
WO2021243289A1
(en)
*
|
2020-05-29 |
2021-12-02 |
The General Hospital Corporation |
Systems and methods for stable and heritable alteration by precision editing (shape)
|
|
CN116782762B
(zh)
|
2020-05-29 |
2024-11-19 |
科沃施种子欧洲股份两合公司 |
植物单倍体诱导
|
|
US11389252B2
(en)
|
2020-06-15 |
2022-07-19 |
Augmedics Ltd. |
Rotating marker for image guided surgery
|
|
WO2022010286A1
(ko)
*
|
2020-07-08 |
2022-01-13 |
경상국립대학교산학협력단 |
미세상동성 기반 말단 결합을 통한 유전자 교정에 이용되는 공여자 핵산 및 이의 용도
|
|
WO2022011356A2
(en)
*
|
2020-07-10 |
2022-01-13 |
President And Fellows Of Harvard College |
Aav vector delivery systems
|
|
CN111979241B
(zh)
*
|
2020-07-23 |
2021-10-01 |
上海市第一人民医院 |
制备视网膜色素变性非人哺乳动物模型的方法
|
|
WO2022018667A1
(en)
|
2020-07-24 |
2022-01-27 |
Pfizer Inc. |
Combination therapies using cdk2 and cdc25a inhibitors
|
|
WO2022032228A1
(en)
|
2020-08-07 |
2022-02-10 |
The Broad Institute, Inc. |
Therapeutic targeting of phosphate dysregulation in cancer via the xpr1:kidins220 protein complex
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
US12239385B2
(en)
|
2020-09-09 |
2025-03-04 |
Augmedics Ltd. |
Universal tool adapter
|
|
WO2022056139A1
(en)
|
2020-09-10 |
2022-03-17 |
Monsanto Technology Llc |
Increasing gene editing and site-directed integration events utilizing meiotic and germline promoters
|
|
CN114250228A
(zh)
*
|
2020-09-22 |
2022-03-29 |
广州瑞风生物科技有限公司 |
靶向CTGF基因的gRNA及其应用
|
|
WO2022068912A1
(en)
|
2020-09-30 |
2022-04-07 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
WO2022188039A1
(en)
|
2021-03-09 |
2022-09-15 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
PL4229205T3
(pl)
|
2020-10-15 |
2025-08-18 |
F. Hoffmann-La Roche Ag |
Konstrukty kwasów nukleinowych do transkrypcji VA RNA
|
|
RU2749307C1
(ru)
*
|
2020-10-30 |
2021-06-08 |
Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт сельскохозяйственной биотехнологии" (ФГБНУ ВНИИСБ) |
Новая компактная нуклеаза CAS9 II типа из Anoxybacillus flavithermus
|
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
|
EP4256052A1
(en)
|
2020-12-02 |
2023-10-11 |
Decibel Therapeutics, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
CN114796493A
(zh)
*
|
2021-01-28 |
2022-07-29 |
中国科学技术大学 |
血管源性bace1作为脑小血管损伤相关疾病的治疗靶点的用途
|
|
MX2023009399A
(es)
|
2021-02-11 |
2023-09-05 |
Arbor Biotechnologies Inc |
Composiciones que comprenden un polipéptido cas12i4 variante y usos de las mismas.
|
|
CN112997966A
(zh)
*
|
2021-03-08 |
2021-06-22 |
国家卫生健康委科学技术研究所 |
一种基于CRISPR/Cas9技术敲入miRNA-125a的小鼠模型及构建方法
|
|
CN115427561B
(zh)
|
2021-03-09 |
2024-06-04 |
辉大(上海)生物科技有限公司 |
工程化CRISPR/Cas13系统及其用途
|
|
WO2022204543A1
(en)
*
|
2021-03-25 |
2022-09-29 |
The Regents Of The University Of California |
Methods and materials for treating huntington's disease
|
|
WO2022240846A1
(en)
|
2021-05-10 |
2022-11-17 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
|
CN113180015A
(zh)
*
|
2021-05-25 |
2021-07-30 |
四川省农业机械研究设计院 |
一种蚕房及三段式流水线养蚕方法
|
|
US20240425830A1
(en)
|
2021-05-27 |
2024-12-26 |
Institute Of Zoology, Chinese Academy Of Sciences |
Engineered cas12i nuclease, effector protein and use thereof
|
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
EP4347826A1
(en)
|
2021-06-02 |
2024-04-10 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
US20240307442A1
(en)
*
|
2021-06-18 |
2024-09-19 |
Innovative Cellular Therapeutics Holdings, Ltd. |
Modified Cell Targeting Tumor ECM and Cellular Therapy thereof
|
|
US11896445B2
(en)
|
2021-07-07 |
2024-02-13 |
Augmedics Ltd. |
Iliac pin and adapter
|
|
WO2023004367A2
(en)
|
2021-07-20 |
2023-01-26 |
The Broad Institute, Inc. |
Engineered targeting compositions for endothelial cells of the central nervous system vasculature and methods of use thereof
|
|
US20230048564A1
(en)
|
2021-07-22 |
2023-02-16 |
Arbor Biotechnologies, Inc. |
Crispr-associated transposon systems and methods of using same
|
|
US12150821B2
(en)
|
2021-07-29 |
2024-11-26 |
Augmedics Ltd. |
Rotating marker and adapter for image-guided surgery
|
|
CN118368974A
(zh)
|
2021-07-30 |
2024-07-19 |
科沃施种子欧洲股份两合公司 |
具有提高的消化率和标记单倍型的植物
|
|
CN113607963B
(zh)
*
|
2021-08-11 |
2024-05-24 |
河南省人民医院 |
一种预测视网膜衰老进程的蛋白标志物、筛选方法及其应用
|
|
EP4384608A1
(en)
|
2021-08-12 |
2024-06-19 |
Arbor Biotechnologies, Inc. |
Compositions comprising a variant cas12i3 polypeptide and uses thereof
|
|
CN113373178A
(zh)
*
|
2021-08-13 |
2021-09-10 |
上海南方模式生物科技股份有限公司 |
一种tlr8基因人源化动物模型的构建方法及应用
|
|
EP4388734A4
(en)
|
2021-08-18 |
2025-05-07 |
Augmedics Ltd. |
Stereoscopic display and digital magnifier for close-up augmented reality viewing
|
|
JP7125727B1
(ja)
|
2021-09-07 |
2022-08-25 |
国立大学法人千葉大学 |
核酸配列改変用組成物および核酸配列の標的部位を改変する方法
|
|
JP2024534945A
(ja)
|
2021-09-10 |
2024-09-26 |
アジレント・テクノロジーズ・インク |
化学修飾を有するプライム編集のためのガイドrna
|
|
US20240392272A1
(en)
|
2021-09-28 |
2024-11-28 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
WO2023059846A1
(en)
|
2021-10-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
|
CN118119702A
(zh)
|
2021-10-14 |
2024-05-31 |
隆萨销售股份有限公司 |
用于细胞外囊泡产生的经修饰的生产者细胞
|
|
CN113913428A
(zh)
*
|
2021-10-14 |
2022-01-11 |
南通大学 |
靶向Tfap2a基因的小干扰RNA及其在制备治疗慢性疼痛药物方面的应用
|
|
US12285497B2
(en)
|
2021-10-15 |
2025-04-29 |
Research Institute At Nationwide Children's Hospital |
Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy
|
|
CN118251491A
(zh)
|
2021-10-28 |
2024-06-25 |
瑞泽恩制药公司 |
用于敲除C5的CRISPR/Cas相关方法及组合物
|
|
WO2023077148A1
(en)
|
2021-11-01 |
2023-05-04 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
CN119120424A
(zh)
|
2021-11-02 |
2024-12-13 |
辉大(上海)生物科技有限公司 |
一种CRISPR-Cas12i系统
|
|
US20250043269A1
(en)
|
2021-11-03 |
2025-02-06 |
The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad |
Precise Genome Editing Using Retrons
|
|
US20240408236A1
(en)
|
2021-11-26 |
2024-12-12 |
Epigenic Therapeutics, Inc. |
Method of modulating pcsk9 and uses thereof
|
|
AU2022408167A1
(en)
|
2021-12-08 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Mutant myocilin disease model and uses thereof
|
|
CN114107231B
(zh)
*
|
2021-12-13 |
2023-08-18 |
重庆大学 |
实现全脑突触后神经元胞体标记的重组腺相关病毒及其应用
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
CN115843318B
(zh)
*
|
2021-12-14 |
2023-07-18 |
中国医学科学院药用植物研究所 |
基于全基因组分析与基因组编辑的植物物种鉴定方法与应用
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
EP4448775A1
(en)
|
2021-12-17 |
2024-10-23 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
WO2023122764A1
(en)
|
2021-12-22 |
2023-06-29 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
EP4457342A1
(en)
|
2021-12-29 |
2024-11-06 |
Bristol-Myers Squibb Company |
Generation of landing pad cell lines
|
|
US20250082777A1
(en)
|
2022-01-10 |
2025-03-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
US20250230412A1
(en)
|
2022-02-01 |
2025-07-17 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2023150518A1
(en)
|
2022-02-01 |
2023-08-10 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023150620A1
(en)
|
2022-02-02 |
2023-08-10 |
Regeneron Pharmaceuticals, Inc. |
Crispr-mediated transgene insertion in neonatal cells
|
|
AU2023216314A1
(en)
|
2022-02-02 |
2024-08-22 |
Inscripta, Inc. |
Nucleic acid-guided nickase fusion proteins
|
|
EP4472407A1
(en)
|
2022-02-03 |
2024-12-11 |
Nicoventures Trading Limited |
Method of modulating alkaloid content in tobacco plants
|
|
JP2025505601A
(ja)
|
2022-02-03 |
2025-02-28 |
ニコベンチャーズ トレーディング リミテッド |
タバコ植物のアルカロイド含有量を調節する方法
|
|
CA3243712A1
(en)
|
2022-02-04 |
2023-08-10 |
Nicoventures Trading Limited |
METHOD FOR MODULATING THE ALKALID CONTENT IN TOBACCO PLANTS
|
|
CN114480497B
(zh)
*
|
2022-02-28 |
2023-09-15 |
湖南师范大学 |
一种ep400基因敲除斑马鱼心力衰竭模型的构建及其应用的方法
|
|
EP4487875A4
(en)
|
2022-02-28 |
2025-07-30 |
National Univ Corporation Tokai National Higher Education And Research System |
MEDICINE FOR A DISEASE CAUSED BY A FRAME-SHIFT MUTATION
|
|
AU2023250649A1
(en)
|
2022-04-04 |
2024-11-14 |
The Regents Of The University Of California |
Genetic complementation compositions and methods
|
|
GB202205148D0
(en)
|
2022-04-07 |
2022-05-25 |
Nicoventures Trading Ltd |
Method
|
|
GB202205149D0
(en)
|
2022-04-07 |
2022-05-25 |
Nicoventures Trading Ltd |
Method
|
|
GB202205561D0
(en)
|
2022-04-14 |
2022-06-01 |
Nicoventures Trading Ltd |
Method
|
|
GB202205562D0
(en)
|
2022-04-14 |
2022-06-01 |
Nicoventures Trading Ltd |
Method
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023203521A1
(en)
|
2022-04-21 |
2023-10-26 |
Augmedics Ltd. |
Systems and methods for medical image visualization
|
|
GB202206109D0
(en)
|
2022-04-27 |
2022-06-08 |
Nicoventures Trading Ltd |
Method
|
|
GB202206107D0
(en)
|
2022-04-27 |
2022-06-08 |
Nicoventures Trading Ltd |
Method
|
|
WO2023212677A2
(en)
|
2022-04-29 |
2023-11-02 |
Regeneron Pharmaceuticals, Inc. |
Identification of tissue-specific extragenic safe harbors for gene therapy approaches
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
US20250302998A1
(en)
|
2022-05-09 |
2025-10-02 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
|
EP4526324A1
(en)
|
2022-05-18 |
2025-03-26 |
The Broad Institute, Inc. |
Engineered viral capsids with increased stability and methods of use thereof
|
|
EP4525892A1
(en)
|
2022-05-19 |
2025-03-26 |
Lyell Immunopharma, Inc. |
Polynucleotides targeting nr4a3 and uses thereof
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
JP2025521154A
(ja)
|
2022-05-31 |
2025-07-08 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
C9orf72反復伸長疾患のためのcrispr干渉療法
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
|
CN115053861A
(zh)
*
|
2022-06-30 |
2022-09-16 |
南方医科大学南方医院 |
一种基于免疫激活的精神分裂症动物模型的构建方法和应用
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
CN120225541A
(zh)
|
2022-07-14 |
2025-06-27 |
博德研究所 |
通过与转铁蛋白受体的相互作用实现cns范围的基因递送的aav衣壳
|
|
CA3262406A1
(en)
|
2022-07-18 |
2024-01-25 |
Renagade Therapeutics Management Inc. |
Gene editing components, systems and methods of use
|
|
EP4558625A1
(en)
|
2022-07-22 |
2025-05-28 |
Arbor Biotechnologies, Inc. |
Compositions comprising a variant nuclease and uses thereof
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
US20240035010A1
(en)
|
2022-07-22 |
2024-02-01 |
Arbor Biotechnologies, Inc. |
Compositions comprising a variant polypeptide and uses thereof
|
|
CN115109799A
(zh)
*
|
2022-07-26 |
2022-09-27 |
华中科技大学同济医学院附属协和医院 |
一种小分子肽的融合质粒及其在抗肿瘤药物中的应用
|
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
|
JP2025525745A
(ja)
|
2022-08-05 |
2025-08-07 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Tdp-43の凝集耐性バリアント
|
|
CN115247149B
(zh)
*
|
2022-08-22 |
2023-06-16 |
华域生物科技(天津)有限公司 |
适用于nk细胞的培养基组合物及培养方法
|
|
WO2024044655A1
(en)
|
2022-08-24 |
2024-02-29 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
US20250386788A1
(en)
|
2022-08-26 |
2025-12-25 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
|
JP2025531829A
(ja)
|
2022-09-13 |
2025-09-25 |
オーグメディックス リミテッド |
画像誘導医療介入のための拡張現実アイウェア
|
|
WO2024064838A1
(en)
|
2022-09-21 |
2024-03-28 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
|
IL319122A
(en)
|
2022-09-28 |
2025-04-01 |
Regeneron Pharma |
Different antibody-resistant receptors improve cell-based therapies
|
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
IL320016A
(en)
|
2022-11-04 |
2025-06-01 |
Regeneron Pharma |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
|
WO2024107765A2
(en)
|
2022-11-14 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
WO2024124044A1
(en)
|
2022-12-07 |
2024-06-13 |
The Brigham And Women’S Hospital, Inc. |
Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
|
|
EP4638766A1
(en)
|
2022-12-20 |
2025-10-29 |
NanoCell Therapeutics Holdings B.V. |
Integrating and self-inactivating viral vectors and constructs and uses thereof
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
WO2024155597A1
(en)
|
2023-01-17 |
2024-07-25 |
Inscripta, Inc. |
Methods and compositions of co-expression of t7rna polymerase and inhibitory rna aptamers
|
|
EP4652288A2
(en)
*
|
2023-01-18 |
2025-11-26 |
Fred Hutchinson Cancer Center |
Viral particle producer cells with landing pad-integrated viral vectors
|
|
GB202300905D0
(en)
|
2023-01-20 |
2023-03-08 |
Nicoventures Trading Ltd |
Method
|
|
KR20250160369A
(ko)
|
2023-01-27 |
2025-11-12 |
리제너론 파마슈티칼스 인코포레이티드 |
변형된 랩도바이러스 당단백질 및 이의 용도
|
|
WO2024163842A2
(en)
|
2023-02-03 |
2024-08-08 |
The Broad Institute, Inc. |
Delivering genes to the brain endothelium to treat lysosomal storage disorder-derived neuropathology
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
GB202303077D0
(en)
|
2023-03-02 |
2023-04-19 |
Univ Oslo |
Brassica plants with improved seed retention
|
|
WO2024192141A1
(en)
|
2023-03-13 |
2024-09-19 |
Dana-Farber Cancer Institute, Inc. |
Treatment of cancers having a drug-resistant mesenchymal cell state
|
|
WO2024197065A2
(en)
*
|
2023-03-20 |
2024-09-26 |
Verve Therapeutics, Inc. |
In vivo nickase-based editing of the lpa gene for treatment of cardiovascular disease
|
|
WO2024197185A1
(en)
|
2023-03-21 |
2024-09-26 |
The Broad Institute, Inc. |
Methods and compositions for dissecting organelle physiology
|
|
KR20250165651A
(ko)
|
2023-03-30 |
2025-11-26 |
칠드런즈 호스피탈 메디칼 센터 |
임상 등급 오가노이드
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
WO2024220574A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
WO2024220741A1
(en)
|
2023-04-19 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for the production of libraries
|
|
WO2024226838A2
(en)
|
2023-04-25 |
2024-10-31 |
The Brigham And Women's Hospital, Inc. |
Treatment of autoimmune diseases having a pathogenic t cell state
|
|
WO2024227131A1
(en)
*
|
2023-04-27 |
2024-10-31 |
Rensselaer Polytechnic Institute |
Recombinant enzyme for the accurate insertion of dna sequences in eukaryotic cells
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024238817A2
(en)
*
|
2023-05-16 |
2024-11-21 |
Fallon Jim Deceased |
Systems and methods for an intranasal drug delivery system
|
|
WO2024238977A2
(en)
|
2023-05-18 |
2024-11-21 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
AU2024274792A1
(en)
|
2023-05-23 |
2025-10-23 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
|
WO2024259309A1
(en)
|
2023-06-15 |
2024-12-19 |
Regeneron Pharmaceuticals, Inc. |
Gene therapy for hearing disorders
|
|
TW202503061A
(zh)
|
2023-06-16 |
2025-01-16 |
大陸商益杰立科(上海)生物科技有限公司 |
靶向b型肝炎病毒基因的表觀編輯工具
|
|
WO2024263961A2
(en)
|
2023-06-23 |
2024-12-26 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
|
TW202509220A
(zh)
|
2023-06-26 |
2025-03-01 |
美商旗艦先鋒創新有限責任(Vii)公司 |
經工程化之瘧原蟲及相關方法
|
|
US20250002946A1
(en)
|
2023-06-30 |
2025-01-02 |
Regeneron Pharmaceuticals, Inc. |
Methods And Compositions For Increasing Homology-Directed Repair
|
|
TW202513801A
(zh)
|
2023-07-28 |
2025-04-01 |
美商雷傑納榮製藥公司 |
用於治療龐貝氏症之抗TfR:GAA及抗CD63:GAA插入
|
|
AR133384A1
(es)
|
2023-07-28 |
2025-09-24 |
Regeneron Pharma |
Anti-tfr:esfingomielinasa ácida para el tratamiento de la deficiencia de esfingomielinasa ácida
|
|
WO2025029654A2
(en)
|
2023-07-28 |
2025-02-06 |
Regeneron Pharmaceuticals, Inc. |
Use of bgh-sv40l tandem polya to enhance transgene expression during unidirectional gene insertion
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2025049524A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
|
WO2025049788A1
(en)
|
2023-08-29 |
2025-03-06 |
The Broad Institute, Inc. |
Optical genetic screens of intracellular and intercellular transcriptional circuits with perturb-fish
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025049959A2
(en)
|
2023-09-01 |
2025-03-06 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025059533A1
(en)
|
2023-09-13 |
2025-03-20 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2025064408A1
(en)
|
2023-09-18 |
2025-03-27 |
The Broad Institute, Inc. |
Compositions and methods for treating cardiovascular disease
|
|
WO2025064591A1
(en)
*
|
2023-09-19 |
2025-03-27 |
The Regents Of The University Of California |
In vivo gene editing of tau locus via liponanoparticle delivery
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025072383A1
(en)
|
2023-09-25 |
2025-04-03 |
The Broad Institute, Inc. |
Viral open reading frames, uses thereof, and methods of detecting the same
|
|
WO2025072803A1
(en)
|
2023-09-29 |
2025-04-03 |
Children's Hospital Medical Center |
Ntrk2 signaling-mediated alveolar capillary injury and repair
|
|
WO2025075911A1
(en)
|
2023-10-02 |
2025-04-10 |
Inscripta, Inc. |
Engineered gpp synthases
|
|
WO2025081042A1
(en)
|
2023-10-12 |
2025-04-17 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
WO2025085423A1
(en)
|
2023-10-19 |
2025-04-24 |
The Broad Institute, Inc. |
Method of multi-locus crispri targeting with a single truncated guide
|
|
WO2025097055A2
(en)
|
2023-11-02 |
2025-05-08 |
The Broad Institute, Inc. |
Compositions and methods of use of t cells in immunotherapy
|
|
WO2025096916A1
(en)
|
2023-11-03 |
2025-05-08 |
The Broad Institute, Inc. |
Multi-site editing in living cells
|
|
WO2025117544A1
(en)
|
2023-11-29 |
2025-06-05 |
The Broad Institute, Inc. |
Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof
|
|
WO2025129158A1
(en)
|
2023-12-15 |
2025-06-19 |
The Broad Institute, Inc. |
Engineered arc delivery vesicles and uses thereof
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025155753A2
(en)
|
2024-01-17 |
2025-07-24 |
Renagade Therapeutics Management Inc. |
Improved gene editing system, guides, and methods
|
|
WO2025155923A1
(en)
|
2024-01-17 |
2025-07-24 |
The Broad Institute, Inc. |
Aav capsid modifications that enable improved cns-wide gene delivery through interactions with the transferrin receptor
|
|
WO2025160155A1
(en)
|
2024-01-22 |
2025-07-31 |
The Broad Institute, Inc. |
Epigenetic targeting of prion diseases
|
|
WO2025166152A1
(en)
|
2024-02-02 |
2025-08-07 |
The Broad Institute, Inc. |
Multiplexed perturbation and decoding in pooled genetic screens
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025184567A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
WO2025212920A1
(en)
|
2024-04-03 |
2025-10-09 |
Children's Hospital Medical Center |
Multi-zonal liver organoids
|
|
WO2025217174A1
(en)
|
2024-04-08 |
2025-10-16 |
The Broad Institute, Inc. |
Aav capsid modifications that enable improved cns-wide gene delivery through interactions with carbonic anhydrase iv
|
|
WO2025217163A2
(en)
|
2024-04-08 |
2025-10-16 |
The Broad Institute, Inc. |
Novel aav capsids binding to human cd59
|
|
WO2025217202A1
(en)
|
2024-04-08 |
2025-10-16 |
Children's Hospital Medical Center |
Bile duct organoid
|
|
WO2025217398A1
(en)
|
2024-04-10 |
2025-10-16 |
Lyell Immunopharma, Inc. |
Methods for culturing cells with improved culture medium
|
|
WO2025224107A1
(en)
|
2024-04-22 |
2025-10-30 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
CN118376795B
(zh)
*
|
2024-05-10 |
2025-10-31 |
厦门大学 |
尿液中n-糖基化蛋白组合作为靶标在早期诊断阿尔茨海默病中的应用
|
|
WO2025244671A1
(en)
|
2024-05-22 |
2025-11-27 |
The Scripps Research Institute |
Compositions for use in treating haploinsufficiency diseases
|
|
WO2025250808A1
(en)
|
2024-05-29 |
2025-12-04 |
The Brigham And Women’S Hospital, Inc. |
Anti-crispr delivery compositions and methods
|
|
WO2025259669A1
(en)
|
2024-06-10 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for characterizing modified oligonucleotides
|
|
US20250388890A1
(en)
|
2024-06-20 |
2025-12-25 |
Regeneron Pharmaceuticals, Inc. |
ASS1 Gene Insertion For The Treatment Of Citrullinemia Type I
|
|
WO2026006542A2
(en)
|
2024-06-26 |
2026-01-02 |
Yale University |
Compositions and methods for crispr/cas9 based reactivation of human angelman syndrome
|