|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
WO2010138263A2
(en)
|
2009-05-28 |
2010-12-02 |
University Of Massachusetts |
Novel aav 's and uses thereof
|
|
CN102638971B
(zh)
|
2009-07-08 |
2015-10-07 |
科马布有限公司 |
动物模型及治疗分子
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9272053B2
(en)
|
2010-04-23 |
2016-03-01 |
University Of Massachusetts |
AAV-based treatment of cholesterol-related disorders
|
|
WO2011140441A2
(en)
|
2010-05-06 |
2011-11-10 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
CN109593814A
(zh)
|
2010-05-12 |
2019-04-09 |
哥伦比亚大学纽约管理委员会 |
筛选分析、鉴别药剂的方法及药物组合物
|
|
EP2689019A2
(en)
|
2011-03-23 |
2014-01-29 |
Pioneer Hi-Bred International Inc. |
Methods for producing a complex transgenic trait locus
|
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
|
US9226976B2
(en)
|
2011-04-21 |
2016-01-05 |
University Of Massachusetts |
RAAV-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
|
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
AU2012311286B2
(en)
|
2011-09-19 |
2018-07-26 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
WO2013045916A1
(en)
|
2011-09-26 |
2013-04-04 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
GB201117313D0
(en)
|
2011-10-07 |
2011-11-16 |
Gt Biolog Ltd |
Bacterium for use in medicine
|
|
EP3604555B1
(en)
|
2011-10-14 |
2024-12-25 |
President and Fellows of Harvard College |
Sequencing by structure assembly
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
WO2014163886A1
(en)
|
2013-03-12 |
2014-10-09 |
President And Fellows Of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9745548B2
(en)
|
2012-03-15 |
2017-08-29 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US10322949B2
(en)
|
2012-03-15 |
2019-06-18 |
Flodesign Sonics, Inc. |
Transducer and reflector configurations for an acoustophoretic device
|
|
US10689609B2
(en)
|
2012-03-15 |
2020-06-23 |
Flodesign Sonics, Inc. |
Acoustic bioreactor processes
|
|
US9458450B2
(en)
|
2012-03-15 |
2016-10-04 |
Flodesign Sonics, Inc. |
Acoustophoretic separation technology using multi-dimensional standing waves
|
|
US9752113B2
(en)
|
2012-03-15 |
2017-09-05 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9950282B2
(en)
|
2012-03-15 |
2018-04-24 |
Flodesign Sonics, Inc. |
Electronic configuration and control for acoustic standing wave generation
|
|
US10967298B2
(en)
|
2012-03-15 |
2021-04-06 |
Flodesign Sonics, Inc. |
Driver and control for variable impedence load
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9637739B2
(en)
*
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
US10039777B2
(en)
|
2012-03-20 |
2018-08-07 |
Neuro-Lm Sas |
Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
US10737953B2
(en)
|
2012-04-20 |
2020-08-11 |
Flodesign Sonics, Inc. |
Acoustophoretic method for use in bioreactors
|
|
RU2645475C2
(ru)
|
2012-04-25 |
2018-02-21 |
Регенерон Фармасьютикалз, Инк. |
Опосредованное нуклеазой нацеливание с большими нацеливающими векторами
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
EP2847215A1
(en)
*
|
2012-05-07 |
2015-03-18 |
Synthes GmbH |
Methods and devices for treating intervertebral disc disease
|
|
LT3401400T
(lt)
|
2012-05-25 |
2019-06-10 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui
|
|
CA2875618C
(en)
|
2012-07-11 |
2021-04-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for the treatment of lysosomal storage diseases
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
PL4397760T3
(pl)
|
2012-10-23 |
2026-03-30 |
Toolgen Incorporated |
Kompozycja do rozszczepiania docelowego dna zawierająca prowadzące rna specyficzne dla docelowego dna i kwas nukleinowy kodujący białko cas lub białko cas oraz jej zastosowanie
|
|
EP3135765A1
(en)
|
2012-12-06 |
2017-03-01 |
Sigma-Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
CN114634950A
(zh)
|
2012-12-12 |
2022-06-17 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
IL239317B
(en)
|
2012-12-12 |
2022-07-01 |
Broad Inst Inc |
Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2896697B1
(en)
|
2012-12-12 |
2015-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
SG10201912991WA
(en)
*
|
2012-12-17 |
2020-03-30 |
Harvard College |
Rna-guided human genome engineering
|
|
EP3919505B1
(en)
|
2013-01-16 |
2023-08-30 |
Emory University |
Uses of cas9-nucleic acid complexes
|
|
SG11201507378UA
(en)
|
2013-03-14 |
2015-10-29 |
Caribou Biosciences Inc |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US10378027B2
(en)
*
|
2013-03-15 |
2019-08-13 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US10077439B2
(en)
|
2013-03-15 |
2018-09-18 |
Modernatx, Inc. |
Removal of DNA fragments in mRNA production process
|
|
US11332719B2
(en)
*
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
EP2971161B1
(en)
|
2013-03-15 |
2018-12-26 |
ModernaTX, Inc. |
Ribonucleic acid purification
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
JP6576904B2
(ja)
*
|
2013-04-04 |
2019-09-18 |
トラスティーズ・オブ・ダートマス・カレッジ |
ＨＩＶ−１プロウイルスＤＮＡのｉｎｖｉｖｏ切除のための組成物及び方法
|
|
JP2016522679A
(ja)
*
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用
|
|
GB201306536D0
(en)
|
2013-04-10 |
2013-05-22 |
Gt Biolog Ltd |
Polypeptide and immune modulation
|
|
DK2986729T3
(en)
|
2013-04-16 |
2018-10-29 |
Regeneron Pharma |
TARGETED MODIFICATION OF ROOT THROUGH
|
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
|
EP3730615A3
(en)
*
|
2013-05-15 |
2020-12-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
ES2670531T3
(es)
*
|
2013-05-29 |
2018-05-30 |
Cellectis S.A. |
Un método para producir una escisión de ADN precisa utilizando la actividad nickasa de Cas9
|
|
US20140356956A1
(en)
*
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
SG10201710030QA
(en)
*
|
2013-06-04 |
2018-01-30 |
Harvard College |
Rna-guided transcriptional regulation
|
|
CN105793425B
(zh)
*
|
2013-06-17 |
2021-10-26 |
布罗德研究所有限公司 |
使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
MX2015017312A
(es)
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたＣＲＩＳＰＲ−Ｃａｓ二重ニッカーゼ系、方法および組成物
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
JP2016528890A
(ja)
*
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ＣＲＩＳＰＲ／Ｃａｓ系を用いるゲノム編集の治療用の使用
|
|
BR112016000571B1
(pt)
*
|
2013-07-10 |
2023-12-26 |
President And Fellows Of Harvard College |
Métodos in vitro para modular a expressão e para alterar um ou mais ácidos nucleicos alvo em uma célula simultaneamente com a regulação da expressão de um ou mais ácidos nucleicos alvo em uma célula, bem como célula de levedura ou bactéria compreendendo ácidos nucleicos
|
|
HUE056760T2
(hu)
|
2013-07-11 |
2022-03-28 |
Modernatx Inc |
A CRISPR-hez kapcsolódó fehérjéket és a szintetikus SGRNS-ket kódoló szintetikus polinukleotidokat tartalmazó készítmények és felhasználási módjaik
|
|
JP6482546B2
(ja)
*
|
2013-07-19 |
2019-03-13 |
ラリクス・バイオサイエンス・リミテッド・ライアビリティ・カンパニーＬａｒｉｘ Ｂｉｏｓｃｉｅｎｃｅ， Ｌｌｃ |
二重対立遺伝子ノックアウトを生成するための方法および組成物
|
|
US10563225B2
(en)
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CA3221516A1
(en)
|
2013-08-22 |
2015-02-26 |
E. I. Du Pont De Nemours And Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
CA2922428A1
(en)
|
2013-08-29 |
2015-03-05 |
Temple University Of The Commonwealth System Of Higher Education |
Methods and compositions for rna-guided treatment of hiv infection
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9745569B2
(en)
|
2013-09-13 |
2017-08-29 |
Flodesign Sonics, Inc. |
System for generating high concentration factors for low cell density suspensions
|
|
ES2844174T3
(es)
|
2013-09-18 |
2021-07-21 |
Kymab Ltd |
Métodos, células y organismos
|
|
CA2925723A1
(en)
|
2013-10-01 |
2015-04-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
WO2015051169A2
(en)
|
2013-10-02 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
CA2930877A1
(en)
*
|
2013-11-18 |
2015-05-21 |
Crispr Therapeutics Ag |
Crispr-cas system materials and methods
|
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
PT3080279T
(pt)
|
2013-12-11 |
2018-12-17 |
Regeneron Pharma |
Métodos e composições para a modificação direcionada de um genoma
|
|
WO2015088643A1
(en)
|
2013-12-11 |
2015-06-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
|
WO2015089427A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
BR112016013213A2
(pt)
|
2013-12-12 |
2017-12-05 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
RU2016128077A
(ru)
|
2013-12-12 |
2018-12-06 |
Те Брод Инститьют Инк. |
Доставка, применение и применения в терапии систем и композиций crispr-cas для лечения обусловленных hbv и вирусных заболеваний и нарушений
|
|
CN111206032B
(zh)
|
2013-12-12 |
2024-07-19 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
CA2935960C
(en)
|
2014-01-08 |
2023-01-10 |
Bart Lipkens |
Acoustophoresis device with dual acoustophoretic chamber
|
|
CN105940110A
(zh)
*
|
2014-01-31 |
2016-09-14 |
菲克特生物科学股份有限公司 |
用于核酸产生和递送的方法和产品
|
|
EP4063503A1
(en)
*
|
2014-02-11 |
2022-09-28 |
The Regents of the University of Colorado, a body corporate |
Crispr enabled multiplexed genome engineering
|
|
EP3107999A4
(en)
|
2014-02-18 |
2017-10-04 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
US10072251B2
(en)
|
2014-02-19 |
2018-09-11 |
University Of Massachusetts |
Recombinant AAVS having useful transcytosis properties
|
|
WO2015130968A2
(en)
|
2014-02-27 |
2015-09-03 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
CA2948728A1
(en)
|
2014-03-10 |
2015-09-17 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
CA3276269A1
(en)
|
2014-03-18 |
2026-03-02 |
University Of Massachusetts |
Raav-based compositions and methods for treating amyotrophic lateral sclerosis
|
|
WO2015148863A2
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3126495A1
(en)
*
|
2014-04-02 |
2017-02-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
US10975391B2
(en)
|
2014-04-25 |
2021-04-13 |
University Of Massachusetts |
Recombinant AAV vectors useful for reducing immunity against transgene products
|
|
US11279934B2
(en)
|
2014-04-28 |
2022-03-22 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
|
|
EP3140403A4
(en)
*
|
2014-05-09 |
2017-12-20 |
Université Laval |
Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system
|
|
JP6570188B2
(ja)
*
|
2014-05-20 |
2019-09-04 |
国立大学法人北海道大学 |
ｓｉＲＮＡ細胞内送達のための脂質膜構造体
|
|
EP3712254A1
(en)
|
2014-05-28 |
2020-09-23 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into gastric tissues through directed differentiation
|
|
KR20170005494A
(ko)
*
|
2014-05-30 |
2017-01-13 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
잠복 바이러스 감염에 대한 치료제를 전달하는 조성물 및 방법
|
|
WO2015187825A2
(en)
|
2014-06-03 |
2015-12-10 |
University Of Massachusetts |
Compositions and methods for modulating dysferlin expression
|
|
RU2704283C9
(ru)
|
2014-06-06 |
2020-02-07 |
Регенерон Фармасьютикалз, Инк. |
Способы и композиции для модификации целевого локуса
|
|
WO2015196128A2
(en)
|
2014-06-19 |
2015-12-23 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
EP3919621A1
(en)
|
2014-06-23 |
2021-12-08 |
The General Hospital Corporation |
Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
|
|
RS60366B1
(sr)
*
|
2014-06-23 |
2020-07-31 |
Regeneron Pharma |
Sastavljanje dnk posredovano nukleazom
|
|
US10487314B2
(en)
|
2014-06-26 |
2019-11-26 |
The Trustees Of Columbia University In The City Of New York |
Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
|
|
PT3161128T
(pt)
|
2014-06-26 |
2018-11-21 |
Regeneron Pharma |
Métodos e composições para modificações genéticas alvejadas e métodos de utilização
|
|
US9744483B2
(en)
|
2014-07-02 |
2017-08-29 |
Flodesign Sonics, Inc. |
Large scale acoustic separation device
|
|
US10760040B1
(en)
|
2014-07-03 |
2020-09-01 |
NanoCav, LLC |
Mechanical transfection devices and methods
|
|
US10081816B1
(en)
*
|
2014-07-03 |
2018-09-25 |
Nant Holdings Ip, Llc |
Mechanical transfection devices and methods
|
|
EP2966170A1
(en)
*
|
2014-07-10 |
2016-01-13 |
Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - |
HBV inactivation
|
|
WO2016007948A1
(en)
*
|
2014-07-11 |
2016-01-14 |
Pioneer Hi-Bred International, Inc. |
Agronomic trait modification using guide rna/cas endonuclease systems and methods of use
|
|
CN106687594A
(zh)
|
2014-07-11 |
2017-05-17 |
纳幕尔杜邦公司 |
用于产生对草甘膦除草剂具有抗性的植物的组合物和方法
|
|
US10179932B2
(en)
|
2014-07-11 |
2019-01-15 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
CA2955238A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US9850521B2
(en)
*
|
2014-08-01 |
2017-12-26 |
Agilent Technologies, Inc. |
In vitro assay buffer for Cas9
|
|
CN106714845A
(zh)
*
|
2014-08-11 |
2017-05-24 |
得克萨斯州大学系统董事会 |
通过crispr/cas9介导的基因编辑预防肌营养不良
|
|
CN107429241B
(zh)
*
|
2014-08-14 |
2025-10-24 |
百奥赛图(北京)医药科技股份有限公司 |
Dna敲入系统
|
|
DK3180426T3
(da)
|
2014-08-17 |
2020-03-30 |
Broad Inst Inc |
Genomredigering ved anvendelse af cas9-nickaser
|
|
CA2959070C
(en)
|
2014-08-27 |
2020-11-10 |
Caribou Biosciences, Inc. |
Methods for increasing cas9-mediated engineering efficiency
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
BR112017003757A2
(pt)
|
2014-09-12 |
2017-12-26 |
Du Pont |
?plantas de milho, partes de planta de milho ou sementes de milho?
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
CN104293831A
(zh)
*
|
2014-09-28 |
2015-01-21 |
上海云舜生物技术有限公司 |
建立高血压小鼠模型的方法及其用途
|
|
EP3200830B1
(en)
|
2014-10-03 |
2020-09-09 |
University of Massachusetts |
High efficiency library-identified aav vectors
|
|
US10370432B2
(en)
|
2014-10-03 |
2019-08-06 |
University Of Massachusetts |
Heterologous targeting peptide grafted AAVS
|
|
WO2016057850A1
(en)
*
|
2014-10-09 |
2016-04-14 |
Seattle Children' S Hospital (Dba Seattle Children' S Research Institute) |
Long poly (a) plasmids and methods for introduction of long poly (a) sequences into the plasmid
|
|
US20170252379A1
(en)
|
2014-10-09 |
2017-09-07 |
Anthrogenesis Corporation |
Placenta-derived adherent cell exosomes and uses thereof
|
|
US20170354745A1
(en)
*
|
2014-10-09 |
2017-12-14 |
The Regents Of The University Of California |
Targeted disruption of a csf1-dap12 pathway member gene for the treatment of neuropathic pain
|
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
SG11201702309RA
(en)
|
2014-10-15 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for generating or maintaining pluripotent cells
|
|
CA2963704A1
(en)
|
2014-10-17 |
2016-04-21 |
Children's Hospital Medical Center |
In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
|
|
CN107208086A
(zh)
*
|
2014-10-17 |
2017-09-26 |
霍华德休斯医学研究所 |
基因组探针
|
|
RU2020140209A
(ru)
|
2014-10-21 |
2021-01-25 |
Юниверсити Оф Массачусетс |
Варианты рекомбинантных aav и их применения
|
|
WO2016069591A2
(en)
|
2014-10-27 |
2016-05-06 |
The Broad Institute Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
EP3212221B1
(en)
*
|
2014-10-29 |
2023-12-06 |
Massachusetts Eye & Ear Infirmary |
Efficient delivery of therapeutic molecules in vitro and in vivo
|
|
JP6788584B2
(ja)
*
|
2014-10-31 |
2020-11-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
Ｃｒｉｓｐｒについての超並列コンビナトリアル遺伝学
|
|
CN107106689A
(zh)
|
2014-11-05 |
2017-08-29 |
沃雅戈治疗公司 |
用于治疗帕金森病的aadc多核苷酸
|
|
EP3215623A4
(en)
|
2014-11-06 |
2018-09-26 |
President and Fellows of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
WO2016073990A2
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
CN112410338A
(zh)
|
2014-11-14 |
2021-02-26 |
沃雅戈治疗公司 |
调节性多核苷酸
|
|
IL292999A
(en)
|
2014-11-14 |
2022-07-01 |
Voyager Therapeutics Inc |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
CA2968440A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
US11168369B2
(en)
|
2014-11-25 |
2021-11-09 |
The Brigham And Women's Hospital, Inc. |
Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
EP3224362B1
(en)
|
2014-11-26 |
2024-09-25 |
The Regents of The University of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
WO2016089433A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
EP3229586B1
(en)
|
2014-12-10 |
2025-07-30 |
Regents of the University of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
EP3230451B1
(en)
|
2014-12-12 |
2021-04-07 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094880A1
(en)
*
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
US10196613B2
(en)
|
2014-12-19 |
2019-02-05 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
BR112017013104A2
(en)
|
2014-12-19 |
2018-05-15 |
Regeneron Pharmaceuticals, Inc. |
methods for modifying a target genomic locus in a cell, for enhancing homologous recombination at a target genomic locus in a cell, and for producing an f0 generation from a nonhuman animal.
|
|
WO2016100974A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
KR20170091157A
(ko)
|
2014-12-23 |
2017-08-08 |
4디 파마 리서치 리미티드 |
피린 폴리펩티드 및 면역 조정
|
|
PL3065748T3
(pl)
|
2014-12-23 |
2018-07-31 |
4D Pharma Research Limited |
Szczep Bacteroides thetaiotaomicron i jego zastosowanie w zmniejszaniu zapalenia
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
CA2972454C
(en)
|
2014-12-31 |
2024-09-10 |
Phykion Inc. |
Compositions and methods for high efficiency in in vivo genome editing
|
|
EP3245232B1
(en)
|
2015-01-12 |
2021-04-21 |
The Regents of The University of California |
Heterodimeric cas9 and methods of use thereof
|
|
US10059940B2
(en)
*
|
2015-01-27 |
2018-08-28 |
Minghong Zhong |
Chemically ligated RNAs for CRISPR/Cas9-lgRNA complexes as antiviral therapeutic agents
|
|
SI3250691T1
(sl)
|
2015-01-28 |
2023-10-30 |
Caribou Biosciences, Inc. |
Hibridni dna/rna-polinukleotidi crispr in postopki za uporabo
|
|
US11180792B2
(en)
|
2015-01-28 |
2021-11-23 |
The Regents Of The University Of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
|
WO2016131009A1
(en)
*
|
2015-02-13 |
2016-08-18 |
University Of Massachusetts |
Compositions and methods for transient delivery of nucleases
|
|
WO2016138488A2
(en)
|
2015-02-26 |
2016-09-01 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
JP6871169B2
(ja)
|
2015-03-02 |
2021-05-12 |
シナイ ヘルス システム |
相同組換え因子
|
|
JP6817215B2
(ja)
|
2015-03-03 |
2021-01-20 |
ザ ジェネラル ホスピタル コーポレイション |
変更ＰＡＭ特異性を有する遺伝子操作ＣＲＩＳＰＲ−Ｃａｓ９ヌクレアーゼ
|
|
CN104673816A
(zh)
*
|
2015-03-05 |
2015-06-03 |
广东医学院 |
一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用
|
|
CN106032540B
(zh)
*
|
2015-03-16 |
2019-10-25 |
中国科学院上海生命科学研究院 |
CRISPR/Cas9核酸内切酶体系的腺相关病毒载体构建及其用途
|
|
GB2536650A
(en)
|
2015-03-24 |
2016-09-28 |
Augmedics Ltd |
Method and system for combining video-based and optic-based augmented reality in a near eye display
|
|
WO2016154176A1
(en)
*
|
2015-03-26 |
2016-09-29 |
Yale University |
Methods and compositions for modifying endothelial cells
|
|
EP3553178A1
(en)
|
2015-03-27 |
2019-10-16 |
E. I. du Pont de Nemours and Company |
Soybean u6 small nuclear rna gene promoters and their use in constitutive expression of small rna genes in plants
|
|
EP3300507A4
(en)
*
|
2015-04-02 |
2019-03-13 |
Agenovir Corporation |
GENERIC ADMINISTRATION AND COMPOSITIONS
|
|
WO2016161446A1
(en)
*
|
2015-04-03 |
2016-10-06 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
|
KR102888521B1
(ko)
|
2015-04-06 |
2025-11-19 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
US11046955B2
(en)
|
2015-04-24 |
2021-06-29 |
University Of Massachusetts |
Modified AAV constructs and uses thereof
|
|
EP3286571B1
(en)
|
2015-04-24 |
2021-08-18 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
US11021699B2
(en)
|
2015-04-29 |
2021-06-01 |
FioDesign Sonics, Inc. |
Separation using angled acoustic waves
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
CA2988854A1
(en)
|
2015-05-08 |
2016-11-17 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
EP3294896A1
(en)
|
2015-05-11 |
2018-03-21 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
WO2016187717A1
(en)
*
|
2015-05-26 |
2016-12-01 |
Exerkine Corporation |
Exosomes useful for genome editing
|
|
CA3000155A1
(en)
*
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Compositions and methods for cell targeted hpv treatment
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
EP3919622A1
(en)
|
2015-06-01 |
2021-12-08 |
Temple University - Of The Commonwealth System of Higher Education |
Methods and compositions for rna-guided treatment of hiv infection
|
|
US10883103B2
(en)
|
2015-06-02 |
2021-01-05 |
Monsanto Technology Llc |
Compositions and methods for delivery of a polynucleotide into a plant
|
|
EP3303634B1
(en)
|
2015-06-03 |
2023-08-30 |
The Regents of The University of California |
Cas9 variants and methods of use thereof
|
|
GB201509578D0
(en)
*
|
2015-06-03 |
2015-07-15 |
Univ Singapore |
Vectors
|
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
|
KR102796744B1
(ko)
|
2015-06-09 |
2025-04-15 |
에디타스 메디신, 인코포레이티드 |
이식의 개선을 위한 crispr/cas-관련 방법 및 조성물
|
|
MD3650033T2
(ro)
|
2015-06-15 |
2022-08-31 |
4D Pharma Res Ltd |
Compoziții conţinând tulpini bacteriene
|
|
SI3240554T1
(sl)
|
2015-06-15 |
2019-12-31 |
4D Pharma Research Limited, |
Blautia stercosis in wexlerae za uporabo v zdravljenju vnetnih in avtoimunskih bolezni
|
|
MA41010B1
(fr)
|
2015-06-15 |
2020-01-31 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
EA201890050A1
(ru)
|
2015-06-15 |
2018-06-29 |
4Д Фарма Рисёрч Лимитед |
Композиции, содержащие бактериальные штаммы
|
|
MA41060B1
(fr)
|
2015-06-15 |
2019-11-29 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
IL293323B2
(en)
|
2015-06-18 |
2024-01-01 |
Massachusetts Inst Technology |
Crispr enzyme mutations reducing off-target effects
|
|
EP3800255A3
(en)
*
|
2015-06-18 |
2021-06-23 |
Robert D. Bowles |
Rna-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
AU2016279077A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
EP3436575A1
(en)
|
2015-06-18 |
2019-02-06 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
CN108271422A
(zh)
|
2015-06-25 |
2018-07-10 |
株式会社国际电气通信基础技术研究所 |
基于器官间串扰系统的预测装置及预测程序
|
|
US20180171302A1
(en)
*
|
2015-06-26 |
2018-06-21 |
Domenico ACCILI |
Genetically Modified IPS Cells That Carry a Marker to Report Expression of Neurogenin3, TPH2, FOXO1 and/or Insulin Genes
|
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
US10456452B2
(en)
|
2015-07-02 |
2019-10-29 |
Poseida Therapeutics, Inc. |
Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles
|
|
US20170000743A1
(en)
*
|
2015-07-02 |
2017-01-05 |
Vindico NanoBio Technology Inc. |
Compositions and Methods for Delivery of Gene Editing Tools Using Polymeric Vesicles
|
|
US10808247B2
(en)
|
2015-07-06 |
2020-10-20 |
Phio Pharmaceuticals Corp. |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
JP7602862B2
(ja)
*
|
2015-07-25 |
2024-12-19 |
ハビブ・フロスト |
がんおよび他の病的状態における治療または治癒を提供する、システム、デバイスおよび方法
|
|
DK3329001T3
(da)
*
|
2015-07-28 |
2021-12-20 |
Danisco Us Inc |
Genomredigeringssystemer og anvendelsesfremgangsmåder
|
|
US11459540B2
(en)
|
2015-07-28 |
2022-10-04 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
US11474085B2
(en)
|
2015-07-28 |
2022-10-18 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
GB2557123B
(en)
|
2015-07-31 |
2021-11-03 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
WO2017027810A2
(en)
|
2015-08-12 |
2017-02-16 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
|
AU2016309948B2
(en)
|
2015-08-14 |
2021-05-20 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
US11214800B2
(en)
|
2015-08-18 |
2022-01-04 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
WO2017035416A2
(en)
*
|
2015-08-25 |
2017-03-02 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016316845B2
(en)
|
2015-08-28 |
2022-03-10 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
IL241462A0
(en)
|
2015-09-10 |
2015-11-30 |
Yeda Res & Dev |
Heterologous engineering of betalain pigments in plants
|
|
CN108350453A
(zh)
|
2015-09-11 |
2018-07-31 |
通用医疗公司 |
核酸酶dsb的完全查询和测序(find-seq)
|
|
SI3350333T1
(sl)
|
2015-09-17 |
2022-04-29 |
ModernaTX,Inc. |
Polinukleotidi, ki zajemajo stabilizacijsko repno regijo
|
|
EP3353296B1
(en)
|
2015-09-24 |
2020-11-04 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
JP2018529353A
(ja)
|
2015-09-30 |
2018-10-11 |
ザ ジェネラル ホスピタル コーポレイション |
配列決定法による切断事象の包括的生体外報告（ＣＩＲＣＬＥ−ｓｅｑ）
|
|
WO2017062754A1
(en)
*
|
2015-10-07 |
2017-04-13 |
New York University |
Compositions and methods for enhancing crispr activity by polq inhibition
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
EP4089175A1
(en)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
EP3364996B1
(en)
|
2015-10-22 |
2021-08-25 |
University of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
CN109153980B
(zh)
|
2015-10-22 |
2023-04-14 |
布罗德研究所有限公司 |
Vi-b型crispr酶和系统
|
|
WO2017070525A1
(en)
|
2015-10-22 |
2017-04-27 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance in neurodegenerative disease
|
|
SG10202104041PA
(en)
|
2015-10-23 |
2021-06-29 |
Harvard College |
Nucleobase editors and uses thereof
|
|
EP3368687B1
(en)
|
2015-10-27 |
2021-09-29 |
The Broad Institute, Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
WO2017075265A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute, Inc. |
Multiplex analysis of single cell constituents
|
|
EP3368054A4
(en)
|
2015-10-28 |
2019-07-03 |
Voyager Therapeutics, Inc. |
REGULATORY EXPRESSION USING THE ADENO-ASSOCIATED VIRUS (AAV)
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
EP3368689B1
(en)
|
2015-10-28 |
2020-06-17 |
The Broad Institute, Inc. |
Composition for modulating immune responses by use of immune cell gene signature
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
|
WO2017079406A1
(en)
|
2015-11-03 |
2017-05-11 |
President And Fellows Of Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
|
US20180327781A1
(en)
*
|
2015-11-09 |
2018-11-15 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Novel rna-based vector system for transient and stable gene expression
|
|
WO2017083722A1
(en)
*
|
2015-11-11 |
2017-05-18 |
Greenberg Kenneth P |
Crispr compositions and methods of using the same for gene therapy
|
|
WO2017083852A1
(en)
|
2015-11-13 |
2017-05-18 |
MOORE, Tara |
Methods for the treatment of corneal dystrophies
|
|
EP3377042A4
(en)
|
2015-11-16 |
2019-05-29 |
The Research Institute at Nationwide Children's Hospital |
MATERIALS AND METHOD FOR THE TREATMENT OF TITIN-BASED MYOPATHIES AND OTHER TITINOPATHIES
|
|
US11905521B2
(en)
|
2015-11-17 |
2024-02-20 |
The Chinese University Of Hong Kong |
Methods and systems for targeted gene manipulation
|
|
CA3005878A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
|
GB201520497D0
(en)
|
2015-11-20 |
2016-01-06 |
4D Pharma Res Ltd |
Compositions comprising bacterial strains
|
|
AU2016357554B2
(en)
|
2015-11-20 |
2019-04-04 |
Cj Bioscience, Inc. |
Compositions comprising bacterial strains
|
|
WO2017091630A1
(en)
|
2015-11-23 |
2017-06-01 |
The Regents Of The University Of California |
Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9
|
|
US20210395799A1
(en)
*
|
2015-11-25 |
2021-12-23 |
Integrated Dna Technologies, Inc. |
Methods for variant detection
|
|
JP6744917B2
(ja)
*
|
2015-11-25 |
2020-08-19 |
インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド |
バリアント検出のための方法
|
|
WO2017095967A2
(en)
|
2015-11-30 |
2017-06-08 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
CN108699557B
(zh)
|
2015-12-04 |
2025-08-15 |
诺华股份有限公司 |
用于免疫肿瘤学的组合物和方法
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
CN105624196A
(zh)
*
|
2015-12-24 |
2016-06-01 |
江苏大学 |
一种建立cyp2c11基因敲除大鼠模型的方法
|
|
CN105624191A
(zh)
*
|
2015-12-24 |
2016-06-01 |
江苏大学 |
一种建立cyp2d1基因敲除大鼠模型的方法
|
|
CN105548420B
(zh)
*
|
2015-12-30 |
2019-08-02 |
上海泽润生物科技有限公司 |
Mops残留量的检测方法
|
|
BR112018013074A2
(en)
|
2015-12-30 |
2018-12-11 |
Novartis Ag |
immune effector cell therapies with enhanced efficacy
|
|
IL304088A
(en)
|
2016-01-11 |
2023-08-01 |
Univ Leland Stanford Junior |
Systems containing chimeric proteins and their uses for controlling gene expression
|
|
MX2018008345A
(es)
|
2016-01-11 |
2018-12-06 |
Univ Leland Stanford Junior |
Proteínas quiméricas y métodos de inmunoterapia.
|
|
US10053693B2
(en)
|
2016-01-19 |
2018-08-21 |
Mubin I. Syed |
Method for controlling obesity using minimally invasive means
|
|
EP3405570A1
(en)
|
2016-01-22 |
2018-11-28 |
The Broad Institute, Inc. |
Crystal structure of crispr cpf1
|
|
WO2017136536A1
(en)
|
2016-02-02 |
2017-08-10 |
University Of Massachusetts |
Method to enhance the efficiency of systemic aav gene delivery to the central nervous system
|
|
WO2017139643A1
(en)
|
2016-02-12 |
2017-08-17 |
University Of Massachusetts |
Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
|
|
CN109415728A
(zh)
*
|
2016-02-15 |
2019-03-01 |
天普大学-联邦高等教育系统 |
逆转录病毒核酸序列的切除
|
|
US10973930B2
(en)
|
2016-02-18 |
2021-04-13 |
The Penn State Research Foundation |
Generating GABAergic neurons in brains
|
|
EP3417061B1
(en)
|
2016-02-18 |
2022-10-26 |
The Regents of the University of California |
Methods and compositions for gene editing in stem cells
|
|
EP3420102B1
(en)
|
2016-02-22 |
2024-04-03 |
Massachusetts Institute of Technology |
Methods for identifying and modulating immune phenotypes
|
|
US10286073B2
(en)
*
|
2016-02-23 |
2019-05-14 |
Ilisa Tech, Inc. |
Magnetic control of gene delivery in vivo
|
|
CA3015665C
(en)
*
|
2016-02-26 |
2020-09-22 |
Lanzatech New Zealand Limited |
Crispr/cas systems for c1-fixing bacteria
|
|
WO2017152023A1
(en)
|
2016-03-04 |
2017-09-08 |
Indoor Biotechnologies Inc. |
Fel d 1 knockouts and associated compositions and methods based on crispr-cas9 genomic editing
|
|
GB201612191D0
(en)
|
2016-07-13 |
2016-08-24 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
EP3520801A1
(en)
|
2016-03-04 |
2019-08-07 |
4D Pharma Plc |
Compositions comprising bacterial blautia strains for treating visceral hypersensitivity
|
|
WO2017161043A1
(en)
|
2016-03-16 |
2017-09-21 |
The J. David Gladstone Institutes |
Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
|
|
US11427861B2
(en)
|
2016-03-17 |
2022-08-30 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
US11597924B2
(en)
|
2016-03-25 |
2023-03-07 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP4005598A1
(en)
|
2016-03-29 |
2022-06-01 |
Karydo Therapeutix, Inc. |
Screening method for candidate substances for active component to prevent or treat at least one disease selected from the group consisting of renal hypofunction, chronic kidney disease and kidney failure
|
|
CN109414504B
(zh)
*
|
2016-03-29 |
2022-04-08 |
无限生物制药公司 |
药物组合物或食品组合物及评价活性成分体内效果的方法
|
|
SI3436077T1
(sl)
*
|
2016-03-30 |
2025-07-31 |
Intellia Therapeutics, Inc. |
Formulacije lipidnih nanodelcev za komponente crispr/cas
|
|
WO2017176929A1
(en)
|
2016-04-05 |
2017-10-12 |
University Of Massachusetts |
Compositions and methods for selective inhibition of grainyhead-like protein expression
|
|
EP3443081A4
(en)
|
2016-04-13 |
2019-10-30 |
Duke University |
CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE
|
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
|
WO2017181105A1
(en)
|
2016-04-15 |
2017-10-19 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance
|
|
SG11201810179RA
(en)
*
|
2016-04-19 |
2018-12-28 |
Broad Inst Inc |
Novel crispr enzymes and systems
|
|
US20200263190A1
(en)
|
2016-04-19 |
2020-08-20 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
AU2017253107B2
(en)
|
2016-04-19 |
2023-07-20 |
Massachusetts Institute Of Technology |
CPF1 complexes with reduced indel activity
|
|
AU2017257624B2
(en)
|
2016-04-25 |
2023-05-25 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
WO2017189542A1
(en)
*
|
2016-04-26 |
2017-11-02 |
University Of Georgia Research Foundation, Inc. |
Plants having reduced methylation of cytosine nucleotides and methods of use
|
|
ES2865481T3
(es)
|
2016-04-29 |
2021-10-15 |
Poseida Therapeutics Inc |
Micelas basadas en poli(histidina) para la complejación y el aporte de proteínas y ácidos nucleicos
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
US11085035B2
(en)
|
2016-05-03 |
2021-08-10 |
Flodesign Sonics, Inc. |
Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
|
|
EP4177335A1
(en)
|
2016-05-05 |
2023-05-10 |
Children's Hospital Medical Center |
Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
|
|
SG11201809699XA
(en)
|
2016-05-18 |
2018-12-28 |
Voyager Therapeutics Inc |
Modulatory polynucleotides
|
|
US20170332610A1
(en)
*
|
2016-05-20 |
2017-11-23 |
Regeneron Pharmaceuticals, Inc. |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US11882815B2
(en)
|
2016-06-15 |
2024-01-30 |
University Of Massachusetts |
Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
|
|
US11788083B2
(en)
|
2016-06-17 |
2023-10-17 |
The Broad Institute, Inc. |
Type VI CRISPR orthologs and systems
|
|
ES2915562T3
(es)
|
2016-06-24 |
2022-06-23 |
Univ Colorado Regents |
Métodos para generar bibliotecas combinatorias con código de barras
|
|
WO2018005445A1
(en)
|
2016-06-27 |
2018-01-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting and treating diabetes
|
|
US12595478B2
(en)
|
2016-06-29 |
2026-04-07 |
The Broad Institute, Inc. |
Crispr-Cas systems having destabilization domain
|
|
EP3484870B1
(en)
|
2016-07-13 |
2022-11-16 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
|
TW201821093A
(zh)
|
2016-07-13 |
2018-06-16 |
英商４Ｄ製藥有限公司 |
包含細菌菌株之組合物
|
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
EP3492096A4
(en)
*
|
2016-07-28 |
2020-04-15 |
Institute for Basic Science |
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF EYE DISEASES WITH CAS9 PROTEINS AND GUIDE RNA
|
|
KR20190041476A
(ko)
|
2016-07-29 |
2019-04-22 |
리제너론 파마슈티칼스 인코포레이티드 |
C-절단된 피브릴린-1의 발현을 유도하는 돌연변이를 포함하는 마우스
|
|
CA3032822A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
KR20250103795A
(ko)
|
2016-08-03 |
2025-07-07 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
JP7215808B2
(ja)
*
|
2016-08-12 |
2023-01-31 |
ツールゲン インコーポレイテッド |
操作された免疫調節エレメントおよび変更された免疫
|
|
WO2018035364A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
IL315358A
(en)
*
|
2016-08-18 |
2024-11-01 |
Univ California |
CRISPR-CAS genome engineering using a modular AAV delivery system
|
|
EP3500677A4
(en)
|
2016-08-20 |
2020-04-01 |
Avellino Lab USA, Inc. |
Single guide rna, crispr/cas9 systems, and methods of use thereof
|
|
WO2019165322A1
(en)
*
|
2018-02-22 |
2019-08-29 |
Moore Tara |
Crispr/cas9 systems, and methods of use thereof
|
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
|
US20220056440A1
(en)
*
|
2016-08-20 |
2022-02-24 |
Tara Moore |
Crispr gene editing for autosomal dominant diseases
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
GB2569252A
(en)
|
2016-08-31 |
2019-06-12 |
Harvard College |
Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
JP7215994B2
(ja)
|
2016-09-06 |
2023-01-31 |
ザ チルドレンズ メディカル センター コーポレーション |
人工多能性幹細胞由来の免疫細胞
|
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
IL247752A0
(en)
|
2016-09-11 |
2016-11-30 |
Yeda Res & Dev |
Compositions and methods for modulating gene expression for site-directed mutagenesis
|
|
US12188059B2
(en)
|
2016-09-13 |
2025-01-07 |
The Broad Institute, Inc. |
Proximity-dependent biotinylation and uses thereof
|
|
US10457940B2
(en)
|
2016-09-22 |
2019-10-29 |
University Of Massachusetts |
AAV treatment of Huntington's disease
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
DK3516056T3
(da)
*
|
2016-09-23 |
2025-02-17 |
Dsm Ip Assets Bv |
Et guide-rna-ekspressionssystem til en værtscelle
|
|
WO2018064208A1
(en)
|
2016-09-28 |
2018-04-05 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
JP2019532644A
(ja)
|
2016-09-30 |
2019-11-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｒｎａ誘導型核酸修飾酵素及びその使用方法
|
|
WO2018064352A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
CA3039409A1
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
CA3040483A1
(en)
|
2016-10-13 |
2018-04-19 |
University Of Massachusetts |
Aav capsid designs
|
|
SG11201903089RA
(en)
|
2016-10-14 |
2019-05-30 |
Harvard College |
Aav delivery of nucleobase editors
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
GB2573406B
(en)
|
2016-10-18 |
2021-11-10 |
Univ Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
CN110494543A
(zh)
|
2016-10-19 |
2019-11-22 |
弗洛设计声能学公司 |
通过声学的亲和细胞提取
|
|
US20180245065A1
(en)
|
2016-11-01 |
2018-08-30 |
Novartis Ag |
Methods and compositions for enhancing gene editing
|
|
SG11201903697WA
(en)
|
2016-11-04 |
2019-05-30 |
Childrens Hospital Med Ct |
Liver organoid compositions and methods of making and using same
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
RU2768043C2
(ru)
|
2016-11-14 |
2022-03-23 |
Тулджен Инкорпорейтед |
Искусственно созданная система управления функцией шк
|
|
EP3548507A4
(en)
|
2016-12-05 |
2020-07-15 |
Children's Hospital Medical Center |
COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
|
|
US12404514B2
(en)
|
2016-12-09 |
2025-09-02 |
The Broad Institute, Inc. |
CRISPR-systems for modifying a trait of interest in a plant
|
|
BR112018015871B1
(pt)
|
2016-12-09 |
2021-12-07 |
The Broad Institute, Inc. |
Sistema, método e dispositivo para detectar a presença de uma sequência alvo de ácido nucleico em uma amostra
|
|
GB201621123D0
(en)
|
2016-12-12 |
2017-01-25 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
US20180179553A1
(en)
|
2016-12-14 |
2018-06-28 |
Ligandal, Inc. |
Compositions and methods for nucleic acid and/or protein payload delivery
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CA3048479A1
(en)
*
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Gene editing of pcsk9
|
|
US11733235B2
(en)
|
2016-12-27 |
2023-08-22 |
Chugai Seiyaku Kabushiki Kaisha |
Method for evaluating immunogenicity of test substance
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
CN106632693B
(zh)
*
|
2017-01-19 |
2021-05-25 |
上海科技大学 |
具有多个核定位序列的SpyCas9蛋白及其应用
|
|
SG11201906735RA
(en)
|
2017-01-23 |
2019-08-27 |
Regeneron Pharma |
Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018147343A1
(en)
*
|
2017-02-07 |
2018-08-16 |
Edigene Corporation |
Method of treating diseases associated with elevated kras expression using crispr-gndm system
|
|
US20190367924A1
(en)
*
|
2017-02-17 |
2019-12-05 |
Temple University - Of The Commonwealth System Of Higher Education |
Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5
|
|
CN118416088A
(zh)
*
|
2017-03-03 |
2024-08-02 |
加利福尼亚大学董事会 |
经由抑制性tRNAs和脱氨酶对突变进行RNA靶向
|
|
US10687520B2
(en)
|
2017-03-07 |
2020-06-23 |
The Board Of Regents Of The University Of Texas System |
Generation and correction of a humanized mouse model with a deletion of dystrophin exon 44
|
|
EP3592381A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Cancer vaccine
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
WO2018165629A1
(en)
|
2017-03-10 |
2018-09-13 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
US11104937B2
(en)
|
2017-03-15 |
2021-08-31 |
The Broad Institute, Inc. |
CRISPR effector system based diagnostics
|
|
US11174515B2
(en)
|
2017-03-15 |
2021-11-16 |
The Broad Institute, Inc. |
CRISPR effector system based diagnostics
|
|
EP3596207B1
(en)
|
2017-03-15 |
2023-12-20 |
The Broad Institute, Inc. |
Novel cas13b orthologues crispr enzymes and systems
|
|
JP2020513815A
(ja)
|
2017-03-15 |
2020-05-21 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
クラスター化短鎖反復回文配列エフェクター系に基づくウイルス検出用診断法
|
|
US12180546B2
(en)
|
2017-03-17 |
2024-12-31 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
EP3600382A4
(en)
*
|
2017-03-21 |
2020-12-30 |
Anthony P. Shuber |
TREATMENT OF CANCER WITH ENDONUCLEASE COMPLEXES CASE
|
|
KR20190130608A
(ko)
|
2017-03-22 |
2019-11-22 |
노파르티스 아게 |
면역종양학을 위한 조성물 및 방법
|
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
US11913075B2
(en)
|
2017-04-01 |
2024-02-27 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
WO2018191520A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
US11618928B2
(en)
|
2017-04-12 |
2023-04-04 |
The Broad Institute, Inc. |
CRISPR effector system based diagnostics for malaria detection
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
WO2018191558A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Modulation of epithelial cell differentiation, maintenance and/or function through t cell action, and markers and methods of use thereof
|
|
EP3610009A1
(en)
|
2017-04-12 |
2020-02-19 |
The Broad Institute, Inc. |
Novel type vi crispr orthologs and systems
|
|
EP3609997A4
(en)
|
2017-04-14 |
2021-03-03 |
Children's Hospital Medical Center |
COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
|
|
US12350368B2
(en)
|
2017-04-14 |
2025-07-08 |
The Broad Institute, Inc. |
Delivery of large payloads
|
|
WO2018195129A1
(en)
|
2017-04-17 |
2018-10-25 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
|
EP3612629A1
(en)
|
2017-04-18 |
2020-02-26 |
The Broad Institute, Inc. |
Compositions for detecting secretion and methods of use
|
|
EP3612023A4
(en)
|
2017-04-20 |
2021-05-12 |
Egenesis, Inc. |
METHOD FOR PRODUCING GENETICALLY MODIFIED ANIMALS
|
|
ES2992912T3
(en)
|
2017-04-21 |
2024-12-19 |
Massachusetts Gen Hospital |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US12208140B2
(en)
|
2017-04-21 |
2025-01-28 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
US11696954B2
(en)
*
|
2017-04-28 |
2023-07-11 |
Exicure Operating Company |
Synthesis of spherical nucleic acids using lipophilic moieties
|
|
US11072816B2
(en)
|
2017-05-03 |
2021-07-27 |
The Broad Institute, Inc. |
Single-cell proteomic assay using aptamers
|
|
WO2018204777A2
(en)
|
2017-05-05 |
2018-11-08 |
The Broad Institute, Inc. |
Methods for identification and modification of lncrna associated with target genotypes and phenotypes
|
|
SG11201909870SA
(en)
|
2017-05-05 |
2019-11-28 |
Voyager Therapeutics Inc |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
CN110914431B
(zh)
|
2017-05-08 |
2024-04-19 |
株式会社图尔金 |
经人工操纵的免疫细胞
|
|
EP3622073A4
(en)
|
2017-05-09 |
2021-01-06 |
University of Massachusetts |
METHOD FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
WO2018208910A1
(en)
|
2017-05-09 |
2018-11-15 |
The Broad Institute Inc. |
Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
CA3062595A1
(en)
|
2017-05-10 |
2018-11-15 |
The Regents Of The University Of California |
Directed editing of cellular rna via nuclear delivery of crispr/cas9
|
|
WO2018209324A2
(en)
|
2017-05-11 |
2018-11-15 |
The Broad Institute, Inc. |
Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
US12195802B2
(en)
*
|
2017-05-12 |
2025-01-14 |
President And Fellows Of Harvard College |
Universal early cancer diagnostics
|
|
US11213825B2
(en)
*
|
2017-05-16 |
2022-01-04 |
Wisconsin Alumni Research Foundation |
System and method for en masse patterning of molecule structures
|
|
US12297436B2
(en)
|
2017-05-18 |
2025-05-13 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
WO2018213708A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
JP7212945B2
(ja)
|
2017-05-22 |
2023-01-26 |
フォーディー ファーマ リサーチ リミテッド |
細菌株を含む組成物
|
|
TW201907931A
(zh)
|
2017-05-24 |
2019-03-01 |
英商4D製藥研究有限公司 |
包含細菌菌株之組合物
|
|
AU2018273986A1
(en)
|
2017-05-25 |
2019-12-12 |
The General Hospital Corporation |
Bipartite base editor (BBE) architectures and type-II-C-Cas9 zinc finger editing
|
|
US11603544B2
(en)
|
2017-06-05 |
2023-03-14 |
Fred Hutchinson Cancer Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
|
JP7518620B2
(ja)
|
2017-06-09 |
2024-07-18 |
エディタス・メディシン，インコーポレイテッド |
操作されたｃａｓ９ヌクレアーゼ
|
|
WO2018229188A1
(en)
|
2017-06-14 |
2018-12-20 |
4D Pharma Research Limited |
Compositions comprising bacterial strains
|
|
CN115813955A
(zh)
|
2017-06-14 |
2023-03-21 |
4D制药研究有限公司 |
包含细菌菌株的组合物
|
|
MD3804737T2
(ro)
|
2017-06-14 |
2022-10-31 |
4D Pharma Res Limited |
Compoziții care conțin tulpini bacteriene
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
WO2018237107A1
(en)
|
2017-06-23 |
2018-12-27 |
University Of Kentucky Research Foundation |
PROCESS
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
CA3064601A1
(en)
|
2017-06-26 |
2019-01-03 |
President And Fellows Of Harvard College |
Crispr/cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
RU2019143627A
(ru)
*
|
2017-06-28 |
2021-07-28 |
Юниверсити Оф Соус Флорида |
Модифицированный ген ube3a для генной терапии синдрома ангельмана
|
|
EP3645721A1
(en)
|
2017-06-30 |
2020-05-06 |
Novartis AG |
Methods for the treatment of disease with gene editing systems
|
|
JP2020530307A
(ja)
|
2017-06-30 |
2020-10-22 |
インティマ・バイオサイエンス，インコーポレーテッド |
遺伝子治療のためのアデノ随伴ウイルスベクター
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
US12548638B2
(en)
|
2017-07-07 |
2026-02-10 |
The Broad Institute, Inc. |
Methods for designing guide sequences for guided nucleases
|
|
EP3648781A4
(en)
|
2017-07-07 |
2021-05-19 |
The Broad Institute, Inc. |
CRISPR SYSTEM BASED ANTIVIRAL THERAPY
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
WO2019014564A1
(en)
|
2017-07-14 |
2019-01-17 |
Editas Medicine, Inc. |
SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
|
|
US12105089B2
(en)
|
2017-07-17 |
2024-10-01 |
The Broad Institute, Inc. |
Cell atlas of the healthy and ulcerative colitis human colon
|
|
WO2019017321A1
(ja)
*
|
2017-07-18 |
2019-01-24 |
国立大学法人京都大学 |
遺伝子変異導入方法
|
|
US12239646B2
(en)
|
2017-07-19 |
2025-03-04 |
Dana-Farber Cancer Institute, Inc. |
Cancer diagnostic and treatment
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
JP2020530990A
(ja)
|
2017-07-31 |
2020-11-05 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
ｉｎ ｖｉｖｏでの外因性ドナー核酸とのＣＲＩＳＰＲ／Ｃａｓ誘導性組換えの評価
|
|
CA3068072A1
(en)
|
2017-07-31 |
2019-02-07 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for assessing crispr/cas-mediated disruption or excision and crispr/cas-induced recombination with an exogenous donor nucleic acid in vivo
|
|
CN110891420B
(zh)
|
2017-07-31 |
2022-06-03 |
瑞泽恩制药公司 |
Cas转基因小鼠胚胎干细胞和小鼠及其应用
|
|
BR102017016440A2
(pt)
|
2017-07-31 |
2019-03-19 |
Universidade Federal Do Rio Grande Do Sul |
Composição para terapia gênica do sistema nervoso central, processo de obtenção e uso da mesma
|
|
CA3073448A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
EP3681501A1
(en)
*
|
2017-09-15 |
2020-07-22 |
The Board of Trustees of the Leland Stanford Junior University |
Mitochondrial aldehyde dehydrogenase-2 modulators for protecting, expanding and increasing the potency of hematopoietic stem cells
|
|
AU2018338318B2
(en)
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11739330B2
(en)
|
2017-09-22 |
2023-08-29 |
University Of Massachusetts |
SOD1 dual expression vectors and uses thereof
|
|
MX2020003019A
(es)
|
2017-09-27 |
2020-08-03 |
Pioneer Hi Bred Int |
Aplicacion en suelo de agentes protectores de cultivos.
|
|
JP2020535160A
(ja)
*
|
2017-09-28 |
2020-12-03 |
タンデム カンパニー，リミテッド |
癌治療用の新規な組換え原形質膜をベースとする小胞体
|
|
JP7139419B2
(ja)
|
2017-09-29 |
2022-09-20 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒト化ｔｔｒ遺伝子座を含む非ヒト動物および使用方法
|
|
BR112020005287A2
(pt)
*
|
2017-09-29 |
2020-09-24 |
Intellia Therapeutics, Inc. |
composições e métodos para edição de gene ttr e tratar amiloidose attr
|
|
WO2019070755A1
(en)
|
2017-10-02 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
|
|
WO2019071051A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
DIAGNOSTICS BASED ON A CRISPR EFFECTOR SYSTEM
|
|
CN111727247A
(zh)
|
2017-10-04 |
2020-09-29 |
博德研究所 |
用于靶向核酸编辑的系统、方法和组合物
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
US12297457B2
(en)
|
2017-10-10 |
2025-05-13 |
Children's Hospital Medical Center |
Esophageal tissue and/or organoid compositions and methods of making same
|
|
WO2019075197A1
(en)
|
2017-10-11 |
2019-04-18 |
The General Hospital Corporation |
METHODS OF DETECTION OF INDIVIDUAL SITE-SPECIFIC PARASITE GENOMIC DEAMINATION BY BASE EDITING TECHNOLOGIES
|
|
US11795443B2
(en)
|
2017-10-16 |
2023-10-24 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
WO2019079362A1
(en)
|
2017-10-16 |
2019-04-25 |
Massachusetts Institute Of Technology |
HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS
|
|
SG11202003024WA
(en)
|
2017-10-20 |
2020-05-28 |
Hutchinson Fred Cancer Res |
Systems and methods to produce b cells genetically modified to express selected antibodies
|
|
WO2019135816A2
(en)
|
2017-10-23 |
2019-07-11 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
WO2019089803A1
(en)
|
2017-10-31 |
2019-05-09 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
US20210180053A1
(en)
|
2017-11-01 |
2021-06-17 |
Novartis Ag |
Synthetic rnas and methods of use
|
|
US12227753B2
(en)
|
2017-11-01 |
2025-02-18 |
The Regents Of The University Of California |
CasY compositions and methods of use
|
|
WO2019090173A1
(en)
|
2017-11-02 |
2019-05-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
|
US12221720B2
(en)
|
2017-11-13 |
2025-02-11 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
EP3710039A4
(en)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
WO2019099943A1
(en)
|
2017-11-16 |
2019-05-23 |
Astrazeneca Ab |
Compositions and methods for improving the efficacy of cas9-based knock-in strategies
|
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
US12521201B2
(en)
|
2017-12-07 |
2026-01-13 |
Augmedics Ltd. |
Spinous process clamp
|
|
US12458411B2
(en)
|
2017-12-07 |
2025-11-04 |
Augmedics Ltd. |
Spinous process clamp
|
|
SG11202003907WA
(en)
|
2017-12-14 |
2020-05-28 |
Flodesign Sonics Inc |
Acoustic transducer drive and controller
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
EP3727394A4
(en)
|
2017-12-21 |
2021-09-08 |
Children's Hospital Medical Center |
DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
|
|
WO2019126709A1
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted dna base editing
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
US20200362366A1
(en)
|
2018-01-12 |
2020-11-19 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
BR112020014140A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
inibidores de dna-pk
|
|
AU2019209292B2
(en)
|
2018-01-17 |
2023-10-05 |
Vertex Pharmaceuticals Incorporated |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
|
JP7391854B2
(ja)
|
2018-01-17 |
2023-12-05 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ｄｎａ－ｐｋ阻害剤
|
|
US12509492B2
(en)
|
2018-01-19 |
2025-12-30 |
Duke University |
Genome engineering with CRISPR-Cas systems in eukaryotes
|
|
US20210371926A1
(en)
|
2018-01-29 |
2021-12-02 |
The Broad Institute, Inc. |
Crispr effector system based diagnostics
|
|
AR114350A1
(es)
|
2018-01-31 |
2020-08-26 |
Res Institute At Nationwide ChildrenS Hospital |
Terapia genética para la distrofia muscular de cinturas del tipo 2c
|
|
CN112203676A
(zh)
*
|
2018-02-02 |
2021-01-08 |
宾州研究基金会 |
治疗脑损伤的方法和材料
|
|
WO2019157304A1
(en)
*
|
2018-02-09 |
2019-08-15 |
Empirico Inc. |
Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions
|
|
EP3755792A4
(en)
|
2018-02-23 |
2021-12-08 |
Pioneer Hi-Bred International, Inc. |
NEW CAS9 ORTHOLOGIST
|
|
US20210054370A1
(en)
*
|
2018-02-27 |
2021-02-25 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for treating angelman syndrome
|
|
AU2019236210B2
(en)
|
2018-03-14 |
2025-07-03 |
Arbor Biotechnologies, Inc. |
Novel CRISPR DNA targeting enzymes and systems
|
|
KR102907245B1
(ko)
|
2018-03-14 |
2026-01-05 |
에디타스 메디신, 인코포레이티드 |
혈색소병증 치료를 위한 시스템 및 방법
|
|
KR101889683B1
(ko)
*
|
2018-03-14 |
2018-08-17 |
유병탁 |
철골 구조 시공 방법
|
|
PT3765616T
(pt)
|
2018-03-14 |
2023-08-28 |
Arbor Biotechnologies Inc |
Novas enzimas e sistemas de direcionamento de dna e rna crispr
|
|
US20190284553A1
(en)
|
2018-03-15 |
2019-09-19 |
KSQ Therapeutics, Inc. |
Gene-regulating compositions and methods for improved immunotherapy
|
|
KR20240038811A
(ko)
|
2018-03-19 |
2024-03-25 |
리제너론 파마슈티칼스 인코포레이티드 |
CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
|
|
US20210017509A1
(en)
*
|
2018-03-23 |
2021-01-21 |
The Trustees Of Columbia University In The City Of New York |
Gene Editing for Autosomal Dominant Diseases
|
|
CN116536272A
(zh)
|
2018-04-06 |
2023-08-04 |
儿童医疗中心有限公司 |
用于体细胞重新编程和调整印记的组合物和方法
|
|
EP3781585A4
(en)
|
2018-04-17 |
2022-01-26 |
The General Hospital Corporation |
SENSITIVE IN VITRO TESTS FOR SUBSTRATE PREFERENCES AND SITE FOR NUCLEIC ACID BINDERS, MODIFIERS AND CLEAVAGE AGENTS
|
|
WO2019204585A1
(en)
|
2018-04-19 |
2019-10-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
|
DK3560330T3
(da)
|
2018-04-24 |
2022-07-11 |
Kws Saat Se & Co Kgaa |
Planter med forbedret fordøjelighed og markørhaplotyper
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
WO2019213065A1
(en)
*
|
2018-04-30 |
2019-11-07 |
Oregon Health & Science University |
Methods of gene therapy
|
|
US11980507B2
(en)
|
2018-05-02 |
2024-05-14 |
Augmedics Ltd. |
Registration of a fiducial marker for an augmented reality system
|
|
AU2019262225B2
(en)
*
|
2018-05-03 |
2025-08-21 |
President And Fellows Of Harvard College |
In vivo homology directed repair in heart, skeletal muscle, and muscle stem cells
|
|
WO2019213660A2
(en)
|
2018-05-04 |
2019-11-07 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
AU2019265019B2
(en)
|
2018-05-11 |
2025-11-06 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
EP3794126A1
(en)
|
2018-05-15 |
2021-03-24 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of parkinson's disease
|
|
EP3794130A4
(en)
|
2018-05-16 |
2022-07-27 |
Synthego Corporation |
METHODS AND SYSTEMS FOR DESIGNING AND USING GUIDE RNA
|
|
US12522812B2
(en)
|
2018-05-16 |
2026-01-13 |
Arbor Biotechnologies, Inc. |
CRISPR-associated systems and components
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CN108707628B
(zh)
*
|
2018-05-28 |
2021-11-23 |
上海海洋大学 |
斑马鱼notch2基因突变体的制备方法
|
|
US20210371932A1
(en)
|
2018-06-01 |
2021-12-02 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US12163129B2
(en)
|
2018-06-08 |
2024-12-10 |
University Of Massachusetts |
Antisense oligonucleotides to restore dysferlin protein expression in dysferlinopathy patient cells
|
|
GB201809588D0
(en)
*
|
2018-06-12 |
2018-07-25 |
Univ Bristol |
Materials and methods for modulating intraocular and intracranial pressure
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
MX2020013461A
(es)
|
2018-06-26 |
2021-04-28 |
Broad Inst Inc |
Composiciones, sistemas y métodos de amplificación basados en la doble nicasa crispr.
|
|
BR112020025319A2
(pt)
|
2018-06-26 |
2021-03-09 |
The Broad Institute Inc. |
Composições, sistemas e métodos de amplificação baseada em crispr/cas e transposase
|
|
EP3814527B1
(en)
|
2018-06-26 |
2023-02-22 |
Massachusetts Institute of Technology |
Crispr effector system based amplification methods, systems, and diagnostics
|
|
WO2020002579A1
(en)
|
2018-06-29 |
2020-01-02 |
Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis |
Tweak-receptor agonists for use in combination with immunotherapy of a cancer
|
|
WO2020006458A1
(en)
|
2018-06-29 |
2020-01-02 |
Research Institute At Nationwide Children's Hospital |
Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2a
|
|
AU2019291918B2
(en)
|
2018-06-29 |
2025-06-12 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
JP2021530212A
(ja)
|
2018-07-13 |
2021-11-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
レトロトランスポゾンベースの送達媒体及びその使用方法
|
|
US20210284981A1
(en)
*
|
2018-07-24 |
2021-09-16 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
US12421500B2
(en)
|
2018-07-26 |
2025-09-23 |
Children's Hospital Medical Center |
Hepato-biliary-pancreatic tissues and methods of making same
|
|
KR20210053898A
(ko)
|
2018-07-31 |
2021-05-12 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규 crispr 효소 및 시스템
|
|
GB201812603D0
(en)
|
2018-08-02 |
2018-09-19 |
British American Tobacco Investments Ltd |
Method
|
|
WO2020033601A1
(en)
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Novel cas12b enzymes and systems
|
|
KR102103103B1
(ko)
*
|
2018-08-16 |
2020-04-21 |
(주)라트바이오 |
인위적 뉴클레아제를 생산하는 형질전환 동물 및 형질전환 배아
|
|
WO2020041217A1
(en)
|
2018-08-18 |
2020-02-27 |
President And Fellows Of Harvard College |
In situ gene editing
|
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
US12460244B2
(en)
|
2018-08-20 |
2025-11-04 |
The Broad Institute, Inc. |
Inhibitors of RNA-guided nuclease activity and uses thereof
|
|
US12391685B2
(en)
|
2018-08-20 |
2025-08-19 |
The Broad Institute, Inc. |
Inhibitors of RNA-guided nuclease target binding and uses thereof
|
|
US12421507B2
(en)
|
2018-08-20 |
2025-09-23 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of CRISPR-CAS9
|
|
EP3841205A4
(en)
|
2018-08-22 |
2022-08-17 |
The Regents of The University of California |
Variant type v crispr/cas effector polypeptides and methods of use thereof
|
|
US20210317479A1
(en)
|
2018-09-06 |
2021-10-14 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
JP2021535753A
(ja)
|
2018-09-12 |
2021-12-23 |
チルドレンズ ホスピタル メディカル センター |
造血幹細胞およびその派生体の生成のためのオルガノイド組成物
|
|
US12398402B2
(en)
|
2018-09-12 |
2025-08-26 |
Fred Hutchinson Cancer Center |
Reducing CD33 expression to selectively protect therapeutic cells
|
|
US20210403907A1
(en)
|
2018-09-18 |
2021-12-30 |
Vnv Newco Inc. |
Arc-based capsids and uses thereof
|
|
EP3852813A4
(en)
|
2018-09-18 |
2022-06-22 |
VNV Newco Inc. |
ARC-BASED CAPSIDS AND THEIR USES
|
|
US12467925B2
(en)
|
2018-10-03 |
2025-11-11 |
The Broad Institute, Inc. |
CRISPR effector system based diagnostics for hemorrhagic fever detection
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
WO2020077135A1
(en)
|
2018-10-10 |
2020-04-16 |
Dana-Farber Cancer Institute, Inc. |
Modulating resistance to bcl-2 inhibitors
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
US20220411783A1
(en)
|
2018-10-12 |
2022-12-29 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
|
CN109295081B
(zh)
*
|
2018-10-17 |
2020-06-12 |
中国人民解放军第四军医大学 |
一种LDLR-Lamp2b融合基因、表达载体及其应用
|
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
US20210388389A1
(en)
|
2018-10-30 |
2021-12-16 |
Yale University |
Compositions and methods for rapid and modular generation of chimeric antigen receptor t cells
|
|
EP3877303B1
(en)
|
2018-11-01 |
2025-03-12 |
Corteva Agriscience LLC |
Systems and methods for manufacture of controlled release of agricultural cores
|
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
GB201817971D0
(en)
|
2018-11-02 |
2018-12-19 |
British American Tobacco Investments Ltd |
Method
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
EP3877517A4
(en)
|
2018-11-09 |
2022-09-07 |
Inari Agriculture, Inc. |
RNA-DRIVEN NUCLEASES AND DNA-BINDING PROTEINS
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
CN114045307A
(zh)
*
|
2018-11-13 |
2022-02-15 |
四川横竖生物科技股份有限公司 |
微注射方法以及应用
|
|
SG11202105083XA
(en)
|
2018-11-14 |
2021-06-29 |
Broad Inst Inc |
Crispr system based droplet diagnostic systems and methods
|
|
MX2021005702A
(es)
|
2018-11-14 |
2021-09-21 |
Massachusetts Inst Technology |
Multiplexión de variantes virales altamente evolutivas con sherlock.
|
|
GB201818715D0
(en)
|
2018-11-16 |
2019-01-02 |
British American Tobacco Investments Ltd |
Method
|
|
US11766296B2
(en)
|
2018-11-26 |
2023-09-26 |
Augmedics Ltd. |
Tracking system for image-guided surgery
|
|
US12258594B2
(en)
|
2018-12-05 |
2025-03-25 |
The Broad Institute, Inc. |
Cas proteins with reduced immunogenicity and methods of screening thereof
|
|
CN113302292B
(zh)
*
|
2018-12-05 |
2024-10-01 |
弗莱德哈钦森癌症中心 |
遗传修饰细胞的减少和最少的操作制造
|
|
KR20210108969A
(ko)
*
|
2018-12-05 |
2021-09-03 |
인텔리아 테라퓨틱스, 인크. |
변형된 아민 지질
|
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
|
WO2020124050A1
(en)
|
2018-12-13 |
2020-06-18 |
The Broad Institute, Inc. |
Tiled assays using crispr-cas based detection
|
|
CN113166744B
(zh)
|
2018-12-14 |
2025-02-07 |
先锋国际良种公司 |
用于基因组编辑的新颖crispr-cas系统
|
|
AU2019406778A1
(en)
|
2018-12-17 |
2021-07-22 |
Massachusetts Institute Of Technology |
Crispr-associated transposase systems and methods of use thereof
|
|
US12264323B2
(en)
|
2018-12-17 |
2025-04-01 |
The Broad Institute, Inc. |
CRISPR CPF1 direct repeat variants
|
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
US11690362B2
(en)
|
2018-12-20 |
2023-07-04 |
Regeneran Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
WO2020146276A2
(en)
*
|
2019-01-07 |
2020-07-16 |
Emendobio Inc. |
Crispr compostions and methods for promoting gene editing of adenosine deaminase 2 (ada2)
|
|
EP3911632A1
(en)
|
2019-01-15 |
2021-11-24 |
Empirico Inc. |
Prodrugs of alox-15 inhibitors and methods of using the same
|
|
GB201900940D0
(en)
|
2019-01-23 |
2019-03-13 |
British American Tobacco Investments Ltd |
Method
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
WO2020160044A1
(en)
|
2019-01-28 |
2020-08-06 |
The Broad Institute, Inc. |
In-situ spatial transcriptomics
|
|
US11965159B2
(en)
|
2019-01-29 |
2024-04-23 |
The Broad Institute, Inc. |
Compositions and methods for regulating proteins and nucleic acids activities
|
|
WO2020160371A1
(en)
|
2019-02-01 |
2020-08-06 |
The University Of Hong Kong |
Innervated organoid compositions and methods of making same
|
|
EP3921417A4
(en)
|
2019-02-04 |
2022-11-09 |
The General Hospital Corporation |
VARIANTS OF ADENINE DNA BASES WITH REDUCED OFF-TARGET RNA EDIT
|
|
WO2020163856A1
(en)
|
2019-02-10 |
2020-08-13 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Modified mitochondrion and methods of use thereof
|
|
CA3236512C
(en)
|
2019-02-13 |
2026-02-24 |
Beam Therapeutics Inc. |
Compositions and methods for treating hemoglobinopathies
|
|
CA3128881A1
(en)
*
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Splice acceptor site disruption of a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
US20230053540A1
(en)
|
2019-02-19 |
2023-02-23 |
Massachusetts Institute Of Technology |
Treatment of liver injury
|
|
CA3131390A1
(en)
|
2019-02-26 |
2020-09-03 |
Research Institute Of Nationwide Children's Hospital |
Adeno-associated virus vector delivery of b-sarcoglycan and the treatment of muscular dystrophy
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
EP4219700A1
(en)
|
2019-03-07 |
2023-08-02 |
The Regents of the University of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
WO2020186101A1
(en)
|
2019-03-12 |
2020-09-17 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
US20220154158A1
(en)
|
2019-03-12 |
2022-05-19 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Cas9 variants with enhanced specificity
|
|
WO2020186237A1
(en)
|
2019-03-13 |
2020-09-17 |
The Broad Institute, Inc. |
Microglial progenitors for regeneration of functional microglia in the central nervous system and therapeutics uses thereof
|
|
US20220154222A1
(en)
|
2019-03-14 |
2022-05-19 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US20220154258A1
(en)
|
2019-03-14 |
2022-05-19 |
The Broad Institute, Inc. |
Crispr effector system based multiplex diagnostics
|
|
US12618101B2
(en)
|
2019-03-14 |
2026-05-05 |
The Broad Institute, Inc. |
Sherlock assays for tick-borne diseases
|
|
EP3937969A1
(en)
|
2019-03-14 |
2022-01-19 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells
|
|
US20220152148A1
(en)
|
2019-03-18 |
2022-05-19 |
The Broad Institute, Inc. |
Modulation of type 2 immunity by targeting clec-2 signaling
|
|
US11845931B2
(en)
|
2019-03-18 |
2023-12-19 |
Regeneron Pharmaceuticals, Inc. |
CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
|
WO2020191102A1
(en)
|
2019-03-18 |
2020-09-24 |
The Broad Institute, Inc. |
Type vii crispr proteins and systems
|
|
EP3942023A1
(en)
|
2019-03-18 |
2022-01-26 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
|
CA3127814C
(en)
|
2019-03-18 |
2024-05-14 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
|
EP3942043A2
(en)
|
2019-03-19 |
2022-01-26 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
CN111733225A
(zh)
*
|
2019-03-25 |
2020-10-02 |
北京大学第一医院 |
一种可用于辅助氯吡格雷精准用药的prkg1基因snp标志物
|
|
WO2020205681A1
(en)
|
2019-03-29 |
2020-10-08 |
Massachusetts Institute Of Technology |
Constructs for continuous monitoring of live cells
|
|
US20220162649A1
(en)
|
2019-04-01 |
2022-05-26 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
US20220175848A1
(en)
|
2019-04-01 |
2022-06-09 |
The Broad Institute, Inc. |
Methods and compositions for cell therapy
|
|
JP7524214B2
(ja)
|
2019-04-03 |
2024-07-29 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
抗体コード配列をセーフハーバー遺伝子座に挿入するための方法および組成物
|
|
ES2966625T3
(es)
|
2019-04-04 |
2024-04-23 |
Regeneron Pharma |
Roedores que comprenden un locus del factor de coagulación 12 humanizado
|
|
AU2020253531C1
(en)
|
2019-04-04 |
2022-06-16 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US20220213469A1
(en)
|
2019-04-30 |
2022-07-07 |
The Broad Institute, Inc. |
Methods and compositions for barcoding nucleic acid libraries and cell populations
|
|
AU2020268959B2
(en)
|
2019-05-03 |
2026-02-19 |
Specific Biologics Inc. |
Lipid-encapsulated dual-cleaving endonuclease for DNA and gene editing
|
|
WO2020231702A1
(en)
*
|
2019-05-11 |
2020-11-19 |
Youngsuk Yi |
Compositions and methods containing exosomes
|
|
US20220243287A1
(en)
|
2019-05-13 |
2022-08-04 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
|
US20220249701A1
(en)
|
2019-05-14 |
2022-08-11 |
The Broad Institute, Inc. |
Compositions and methods for targeting multinucleated cells
|
|
GB201906768D0
(en)
|
2019-05-14 |
2019-06-26 |
British American Tobacco Investments Ltd |
Method
|
|
WO2020236972A2
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
US20220233654A1
(en)
*
|
2019-05-21 |
2022-07-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Expression vector for cholesterol 24-hydrolase in therapy of rett syndrome
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
WO2020243371A1
(en)
|
2019-05-28 |
2020-12-03 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
US20220243178A1
(en)
|
2019-05-31 |
2022-08-04 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
CA3141814A1
(en)
|
2019-05-31 |
2020-12-03 |
Children's Hospital Medical Center |
Shaped organoid compositions and methods of making same
|
|
CN114174494A
(zh)
|
2019-05-31 |
2022-03-11 |
儿童医院医学中心 |
产生和扩增造血干细胞的方法
|
|
US11891618B2
(en)
|
2019-06-04 |
2024-02-06 |
Regeneron Pharmaceuticals, Inc. |
Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
|
|
US12188045B2
(en)
|
2019-06-07 |
2025-01-07 |
KSQ Therapeutics, Inc. |
Guide RNA combinations and methods of use
|
|
CA3137764A1
(en)
|
2019-06-07 |
2020-12-10 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized albumin locus
|
|
KR20220024053A
(ko)
|
2019-06-14 |
2022-03-03 |
리제너론 파마슈티칼스 인코포레이티드 |
타우병증의 모델
|
|
WO2020257514A1
(en)
*
|
2019-06-21 |
2020-12-24 |
Children's Medical Center Corporation |
Methods and compositions for allele specific gene editing
|
|
JP2022539248A
(ja)
|
2019-07-02 |
2022-09-07 |
フレッド ハッチンソン キャンサー リサーチ センター |
組換えａｄ３５ベクター及び関連遺伝子治療改善
|
|
GB201909563D0
(en)
|
2019-07-03 |
2019-08-14 |
British American Tobacco Investments Ltd |
Method
|
|
GB201909562D0
(en)
|
2019-07-03 |
2019-08-14 |
British American Tobacco Investments Ltd |
Method
|
|
US11980506B2
(en)
|
2019-07-29 |
2024-05-14 |
Augmedics Ltd. |
Fiducial marker
|
|
US12178666B2
(en)
|
2019-07-29 |
2024-12-31 |
Augmedics Ltd. |
Fiducial marker
|
|
WO2021026294A1
(en)
|
2019-08-06 |
2021-02-11 |
Children's Medical Center Corporation |
Methods and compositions for reconstituting microglia
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
WO2021030627A1
(en)
|
2019-08-13 |
2021-02-18 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
EP4488287A3
(en)
|
2019-08-21 |
2025-03-05 |
Research Institute at Nationwide Children's Hospital |
Adeno-associated virus vector delivery of alpha-sarcoglycan and the treatment of muscular dystrophy
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
US20220333208A1
(en)
|
2019-09-03 |
2022-10-20 |
The Broad Institute, Inc. |
Crispr effector system based multiplex cancer diagnostics
|
|
JP2022547570A
(ja)
|
2019-09-12 |
2022-11-14 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
操作済みのアデノ随伴ウイルスキャプシド
|
|
US20210079394A1
(en)
|
2019-09-13 |
2021-03-18 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems delivered by lipid nanoparticles
|
|
US12264367B2
(en)
|
2019-09-19 |
2025-04-01 |
The Broad Institute, Inc. |
Methods of in vivo evaluation of gene function
|
|
US20230025039A1
(en)
|
2019-09-20 |
2023-01-26 |
The Broad Institute, Inc. |
Novel type vi crispr enzymes and systems
|
|
EP4031561A1
(en)
|
2019-09-20 |
2022-07-27 |
The Broad Institute, Inc. |
Compositions and methods for delivering cargo to a target cell
|
|
GB201913974D0
(en)
*
|
2019-09-27 |
2019-11-13 |
King S College London |
Vector
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CA3153902A1
(en)
|
2019-10-16 |
2021-04-22 |
Pardis SABETI |
Engineered muscle targeting compositions
|
|
WO2021074367A1
(en)
|
2019-10-17 |
2021-04-22 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
JP7756639B2
(ja)
|
2019-11-08 |
2025-10-20 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｘ連鎖性若年網膜分離療法のためのｃｒｉｓｐｒおよびａａｖ戦略
|
|
US12195723B2
(en)
|
2019-11-08 |
2025-01-14 |
The Broad Institute, Inc. |
Engineered antigen presenting cells and uses thereof
|
|
CN110684801A
(zh)
*
|
2019-11-13 |
2020-01-14 |
武汉华美生物工程有限公司 |
转导cas9基因到哺乳动物细胞进行基因编辑的方法
|
|
WO2021102084A1
(en)
|
2019-11-22 |
2021-05-27 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
US12241830B2
(en)
|
2019-12-06 |
2025-03-04 |
Broad Institute, Inc. |
Living biosensors
|
|
EP3835309A1
(en)
|
2019-12-13 |
2021-06-16 |
KWS SAAT SE & Co. KGaA |
Method for increasing cold or frost tolerance in a plant
|
|
US11382712B2
(en)
|
2019-12-22 |
2022-07-12 |
Augmedics Ltd. |
Mirroring in image guided surgery
|
|
IL292896A
(en)
*
|
2019-12-23 |
2022-07-01 |
Univ California |
CRISPR-Cas execution poplipeptides and methods of using them
|
|
WO2021146641A1
(en)
|
2020-01-17 |
2021-07-22 |
The Broad Institute, Inc. |
Small type ii-d cas proteins and methods of use thereof
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
IL294715A
(en)
|
2020-01-23 |
2022-09-01 |
Childrens Medical Ct Corp |
Stroma-free t cell differentiation from human pluripotent stem cells
|
|
WO2021151073A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants
|
|
WO2021151085A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Crispr-cas enzymes with enhanced on-target activity
|
|
CN115362264A
(zh)
|
2020-01-29 |
2022-11-18 |
10X基因组学有限公司 |
用于分析物检测的组合物和方法
|
|
CN113281130B
(zh)
*
|
2020-02-20 |
2024-08-23 |
中国科学院上海高等研究院 |
一种用于大尺寸脑组织的高效的高尔基染色方法
|
|
EP3872190A1
(en)
|
2020-02-26 |
2021-09-01 |
Antibodies-Online GmbH |
A method of using cut&run or cut&tag to validate crispr-cas targeting
|
|
WO2021168799A1
(en)
*
|
2020-02-28 |
2021-09-02 |
Huigene Therapeutics Co., Ltd. |
Type vi-e and type vi-f crispr-cas system and uses thereof
|
|
CA3167369A1
(en)
|
2020-03-04 |
2021-09-10 |
Tara YOUNG |
Methods and compositions for sensitization of tumor cells to immune therapy
|
|
CN111321150B
(zh)
*
|
2020-03-13 |
2020-12-04 |
广西壮族自治区水产科学研究院 |
一种LvCTL4基因及编码的蛋白质、蛋白质的获取方法、表达载体、重组菌和应用
|
|
EP4121532B1
(en)
|
2020-03-17 |
2025-07-30 |
The Broad Institute, Inc. |
Crispr system high throughput diagnostic systems and methods
|
|
EP4125348A1
(en)
|
2020-03-23 |
2023-02-08 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
US11639523B2
(en)
|
2020-03-23 |
2023-05-02 |
The Broad Institute, Inc. |
Type V CRISPR-Cas systems and use thereof
|
|
KR20230009379A
(ko)
|
2020-03-31 |
2023-01-17 |
아버 바이오테크놀로지스, 인크. |
Cas12i2 변이체 폴리펩타이드를 포함하는 조성물 및 이의 용도
|
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
BR112022020546A2
(pt)
|
2020-04-09 |
2022-12-20 |
Reynolds Tobacco Co R |
Método
|
|
WO2021211734A1
(en)
*
|
2020-04-15 |
2021-10-21 |
The Regents Of The University Of California |
Compositions and methods for treatment
|
|
US20230165909A1
(en)
|
2020-04-21 |
2023-06-01 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
|
US20250263752A1
(en)
|
2020-04-21 |
2025-08-21 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
|
EP4146797A1
(en)
|
2020-05-06 |
2023-03-15 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
|
BR112022022603A2
(pt)
|
2020-05-08 |
2023-01-17 |
Broad Inst Inc |
Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla
|
|
WO2021231575A1
(en)
*
|
2020-05-12 |
2021-11-18 |
Myogene Bio Llc |
Immunosuppressive agents and viral delivery re-dosing methods for gene therapy
|
|
CA3178951A1
(en)
*
|
2020-05-15 |
2021-11-18 |
Yan Shi |
T cell, preparation method for same, and applications thereof
|
|
CN111521826A
(zh)
*
|
2020-05-21 |
2020-08-11 |
江海松 |
外周血外泌体中Notch3蛋白作为分子标记的应用及一种检测试剂盒
|
|
WO2021239986A1
(en)
|
2020-05-29 |
2021-12-02 |
KWS SAAT SE & Co. KGaA |
Plant haploid induction
|
|
WO2021243289A1
(en)
*
|
2020-05-29 |
2021-12-02 |
The General Hospital Corporation |
Systems and methods for stable and heritable alteration by precision editing (shape)
|
|
US11389252B2
(en)
|
2020-06-15 |
2022-07-19 |
Augmedics Ltd. |
Rotating marker for image guided surgery
|
|
KR102687692B1
(ko)
*
|
2020-07-08 |
2024-07-24 |
경상국립대학교산학협력단 |
미세상동성 기반 말단 결합을 통한 유전자 교정에 이용되는 공여자 핵산 및 이의 용도
|
|
US20230321278A1
(en)
*
|
2020-07-10 |
2023-10-12 |
President And Fellows Of Harvard College |
Aav vector delivery systems
|
|
US20230159949A1
(en)
|
2020-07-22 |
2023-05-25 |
The Broad Institute, Inc. |
Engineered muscle targeting compositions
|
|
CN111979241B
(zh)
*
|
2020-07-23 |
2021-10-01 |
上海市第一人民医院 |
制备视网膜色素变性非人哺乳动物模型的方法
|
|
WO2022018667A1
(en)
|
2020-07-24 |
2022-01-27 |
Pfizer Inc. |
Combination therapies using cdk2 and cdc25a inhibitors
|
|
AU2021321586A1
(en)
|
2020-08-07 |
2023-03-16 |
Dana-Farber Cancer Institute, Inc. |
Therapeutic targeting of phosphate dysregulation in cancer via the XPR1:KIDINS220 protein complex
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
US12239385B2
(en)
|
2020-09-09 |
2025-03-04 |
Augmedics Ltd. |
Universal tool adapter
|
|
US12502163B2
(en)
|
2020-09-09 |
2025-12-23 |
Augmedics Ltd. |
Universal tool adapter for image-guided surgery
|
|
US11981900B2
(en)
|
2020-09-10 |
2024-05-14 |
Monsanto Technology Llc |
Increasing gene editing and site-directed integration events utilizing meiotic and germline promoters
|
|
CN114250228A
(zh)
*
|
2020-09-22 |
2022-03-29 |
广州瑞风生物科技有限公司 |
靶向CTGF基因的gRNA及其应用
|
|
WO2022188039A1
(en)
|
2021-03-09 |
2022-09-15 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
WO2022068912A1
(en)
|
2020-09-30 |
2022-04-07 |
Huigene Therapeutics Co., Ltd. |
Engineered crispr/cas13 system and uses thereof
|
|
KR20230085929A
(ko)
|
2020-10-15 |
2023-06-14 |
에프. 호프만-라 로슈 아게 |
Va rna 전사를 위한 핵산 구조체
|
|
RU2749307C1
(ru)
*
|
2020-10-30 |
2021-06-08 |
Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт сельскохозяйственной биотехнологии" (ФГБНУ ВНИИСБ) |
Новая компактная нуклеаза CAS9 II типа из Anoxybacillus flavithermus
|
|
EP4001429A1
(en)
|
2020-11-16 |
2022-05-25 |
Antibodies-Online GmbH |
Analysis of crispr-cas binding and cleavage sites followed by high-throughput sequencing (abc-seq)
|
|
EP4256052A1
(en)
|
2020-12-02 |
2023-10-11 |
Decibel Therapeutics, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
CN114796493B
(zh)
*
|
2021-01-28 |
2026-02-10 |
中国科学技术大学 |
血管源性bace1作为脑小血管损伤相关疾病的治疗靶点的用途
|
|
AU2022220332A1
(en)
|
2021-02-11 |
2023-08-24 |
Arbor Biotechnologies, Inc. |
Compositions comprising a variant cas12i4 polypeptide and uses thereof
|
|
CN112997966A
(zh)
*
|
2021-03-08 |
2021-06-22 |
国家卫生健康委科学技术研究所 |
一种基于CRISPR/Cas9技术敲入miRNA-125a的小鼠模型及构建方法
|
|
CN115427561B
(zh)
|
2021-03-09 |
2024-06-04 |
辉大(上海)生物科技有限公司 |
工程化CRISPR/Cas13系统及其用途
|
|
WO2022204543A1
(en)
*
|
2021-03-25 |
2022-09-29 |
The Regents Of The University Of California |
Methods and materials for treating huntington's disease
|
|
WO2022240846A1
(en)
|
2021-05-10 |
2022-11-17 |
Sqz Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
|
CN113180015A
(zh)
*
|
2021-05-25 |
2021-07-30 |
四川省农业机械研究设计院 |
一种蚕房及三段式流水线养蚕方法
|
|
WO2022247873A1
(zh)
|
2021-05-27 |
2022-12-01 |
中国科学院动物研究所 |
工程化的Cas12i核酸酶、效应蛋白及其用途
|
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
JP2024520676A
(ja)
|
2021-06-02 |
2024-05-24 |
ライエル・イミュノファーマ・インコーポレイテッド |
Ｎｒ４ａ３欠損免疫細胞及びその使用
|
|
EP4355351A1
(en)
*
|
2021-06-18 |
2024-04-24 |
Innovative Cellular Therapeutics Holdings, Ltd. |
Modified cells targeting tumor ecm and therapy thereof
|
|
US11896445B2
(en)
|
2021-07-07 |
2024-02-13 |
Augmedics Ltd. |
Iliac pin and adapter
|
|
EP4373837A2
(en)
|
2021-07-20 |
2024-05-29 |
The Broad Institute, Inc. |
Engineered targeting compositions for endothelial cells of the central nervous system vasculature and methods of use thereof
|
|
EP4373928A2
(en)
|
2021-07-22 |
2024-05-29 |
Arbor Biotechnologies, Inc. |
Crispr-associated transposon systems and methods of using same
|
|
US12150821B2
(en)
|
2021-07-29 |
2024-11-26 |
Augmedics Ltd. |
Rotating marker and adapter for image-guided surgery
|
|
CA3221517A1
(en)
|
2021-07-30 |
2023-02-02 |
Monika KLOIBER-MAITZ |
Plants with improved digestibility and marker haplotypes
|
|
CN113607963B
(zh)
*
|
2021-08-11 |
2024-05-24 |
河南省人民医院 |
一种预测视网膜衰老进程的蛋白标志物、筛选方法及其应用
|
|
EP4384608A1
(en)
|
2021-08-12 |
2024-06-19 |
Arbor Biotechnologies, Inc. |
Compositions comprising a variant cas12i3 polypeptide and uses thereof
|
|
CN113373178A
(zh)
*
|
2021-08-13 |
2021-09-10 |
上海南方模式生物科技股份有限公司 |
一种tlr8基因人源化动物模型的构建方法及应用
|
|
EP4388734A4
(en)
|
2021-08-18 |
2025-05-07 |
Augmedics Ltd. |
Stereoscopic display and digital magnifier for close-up augmented reality viewing
|
|
JP7125727B1
(ja)
|
2021-09-07 |
2022-08-25 |
国立大学法人千葉大学 |
核酸配列改変用組成物および核酸配列の標的部位を改変する方法
|
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
|
EP4596697A3
(en)
|
2021-09-28 |
2025-08-27 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
IL311885A
(en)
|
2021-10-08 |
2024-06-01 |
Harvard College |
Ionic liquids for drug delivery
|
|
IL311962A
(en)
|
2021-10-14 |
2024-06-01 |
Lonza Sales Ag |
Modified producer cells for extracellular vesicle production
|
|
CN113913428A
(zh)
*
|
2021-10-14 |
2022-01-11 |
南通大学 |
靶向Tfap2a基因的小干扰RNA及其在制备治疗慢性疼痛药物方面的应用
|
|
US12285497B2
(en)
|
2021-10-15 |
2025-04-29 |
Research Institute At Nationwide Children's Hospital |
Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy
|
|
JP2024540086A
(ja)
|
2021-10-28 |
2024-10-31 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｃ５をノックアウトするためのｃｒｉｓｐｒ／ｃａｓ関連方法及び組成物
|
|
WO2023077148A1
(en)
|
2021-11-01 |
2023-05-04 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
CN119120424A
(zh)
|
2021-11-02 |
2024-12-13 |
辉大(上海)生物科技有限公司 |
一种CRISPR-Cas12i系统
|
|
EP4426832A1
(en)
|
2021-11-03 |
2024-09-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone |
Precise genome editing using retrons
|
|
US20240408236A1
(en)
|
2021-11-26 |
2024-12-12 |
Epigenic Therapeutics, Inc. |
Method of modulating pcsk9 and uses thereof
|
|
US12582104B2
(en)
|
2021-12-08 |
2026-03-24 |
Regeneron Pharmaceuticals, Inc. |
Mutant myocilin disease model and uses thereof
|
|
CN114107231B
(zh)
*
|
2021-12-13 |
2023-08-18 |
重庆大学 |
实现全脑突触后神经元胞体标记的重组腺相关病毒及其应用
|
|
WO2023108430A1
(zh)
*
|
2021-12-14 |
2023-06-22 |
中国医学科学院药用植物研究所 |
基于全基因组分析与基因组编辑的植物物种鉴定方法与应用
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
WO2023115041A1
(en)
|
2021-12-17 |
2023-06-22 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
EP4452335A1
(en)
|
2021-12-22 |
2024-10-30 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
EP4457342A1
(en)
|
2021-12-29 |
2024-11-06 |
Bristol-Myers Squibb Company |
Generation of landing pad cell lines
|
|
WO2023133595A2
(en)
|
2022-01-10 |
2023-07-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
EP4472646A1
(en)
|
2022-02-01 |
2024-12-11 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
AU2023216314A1
(en)
|
2022-02-02 |
2024-08-22 |
Inscripta, Inc. |
Nucleic acid-guided nickase fusion proteins
|
|
CA3242731A1
(en)
|
2022-02-02 |
2023-08-10 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertions for treatment of pompe disease
|
|
EP4472407A1
(en)
|
2022-02-03 |
2024-12-11 |
Nicoventures Trading Limited |
Method of modulating alkaloid content in tobacco plants
|
|
US20250137006A1
(en)
|
2022-02-03 |
2025-05-01 |
Nicoventures Trading Limited |
Method of modulating alkaloid content in tobacco plants
|
|
AU2023215671B2
(en)
|
2022-02-04 |
2026-04-23 |
Nicoventures Trading Limited |
Method of modulating alkaloid content in tobacco plants
|
|
JPWO2023163131A1
(enExample)
|
2022-02-28 |
2023-08-31 |
|
|
|
CN114480497B
(zh)
*
|
2022-02-28 |
2023-09-15 |
湖南师范大学 |
一种ep400基因敲除斑马鱼心力衰竭模型的构建及其应用的方法
|
|
CA3255225A1
(en)
|
2022-04-04 |
2023-10-12 |
The Regents Of The University Of California |
COMPOSITIONS AND METHODS OF GENETIC COMPLEMENTATION
|
|
GB202205149D0
(en)
|
2022-04-07 |
2022-05-25 |
Nicoventures Trading Ltd |
Method
|
|
GB202205148D0
(en)
|
2022-04-07 |
2022-05-25 |
Nicoventures Trading Ltd |
Method
|
|
GB202205561D0
(en)
|
2022-04-14 |
2022-06-01 |
Nicoventures Trading Ltd |
Method
|
|
GB202205562D0
(en)
|
2022-04-14 |
2022-06-01 |
Nicoventures Trading Ltd |
Method
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023203521A1
(en)
|
2022-04-21 |
2023-10-26 |
Augmedics Ltd. |
Systems and methods for medical image visualization
|
|
GB202206109D0
(en)
|
2022-04-27 |
2022-06-08 |
Nicoventures Trading Ltd |
Method
|
|
GB202206107D0
(en)
|
2022-04-27 |
2022-06-08 |
Nicoventures Trading Ltd |
Method
|
|
EP4514981A2
(en)
|
2022-04-29 |
2025-03-05 |
Regeneron Pharmaceuticals, Inc. |
Identification of tissue-specific extragenic safe harbors for gene therapy approaches
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
EP4522726A1
(en)
|
2022-05-09 |
2025-03-19 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
|
WO2023225564A1
(en)
|
2022-05-18 |
2023-11-23 |
The Broad Institute, Inc. |
Engineered viral capsids with increased stability and methods of use thereof
|
|
KR20250027283A
(ko)
|
2022-05-19 |
2025-02-25 |
라이엘 이뮤노파마, 인크. |
nr4a3을 표적하는 폴리뉴클레오타이드 및 이의 용도
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
JP2025521154A
(ja)
|
2022-05-31 |
2025-07-08 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｃ９ｏｒｆ７２反復伸長疾患のためのｃｒｉｓｐｒ干渉療法
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
KR20250044484A
(ko)
|
2022-06-24 |
2025-03-31 |
튠 쎄라퓨틱스, 인코포레이티드 |
표적 유전자 억제를 통해 저밀도 지단백질을 감소시키기 위한 조성물, 시스템, 및 방법
|
|
CN115053861A
(zh)
*
|
2022-06-30 |
2022-09-16 |
南方医科大学南方医院 |
一种基于免疫激活的精神分裂症动物模型的构建方法和应用
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
AU2023307223A1
(en)
|
2022-07-14 |
2025-02-20 |
The Broad Institute, Inc. |
Aav capsids that enable cns-wide gene delivery through interactions with the transferrin receptor
|
|
CN120344660A
(zh)
|
2022-07-18 |
2025-07-18 |
雷纳嘉德医疗管理公司 |
基因编辑组分、系统和使用方法
|
|
WO2024020557A1
(en)
|
2022-07-22 |
2024-01-25 |
Arbor Biotechnologies, Inc. |
Compositions comprising a variant nuclease and uses thereof
|
|
US20240035010A1
(en)
|
2022-07-22 |
2024-02-01 |
Arbor Biotechnologies, Inc. |
Compositions comprising a variant polypeptide and uses thereof
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
CN115109799A
(zh)
*
|
2022-07-26 |
2022-09-27 |
华中科技大学同济医学院附属协和医院 |
一种小分子肽的融合质粒及其在抗肿瘤药物中的应用
|
|
KR20250054842A
(ko)
|
2022-07-29 |
2025-04-23 |
리제너론 파마슈티칼스 인코포레이티드 |
뇌 및 근육으로의 트랜스페린 수용체(tfr)-매개 전달을 위한 조성물 및 방법
|
|
KR20250044256A
(ko)
|
2022-08-05 |
2025-03-31 |
리제너론 파마슈티칼스 인코포레이티드 |
Tdp-43의 응집 저항성 변이체
|
|
CN115247149B
(zh)
*
|
2022-08-22 |
2023-06-16 |
华域生物科技(天津)有限公司 |
适用于nk细胞的培养基组合物及培养方法
|
|
US20260055146A1
(en)
|
2022-08-24 |
2026-02-26 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
US20250386788A1
(en)
|
2022-08-26 |
2025-12-25 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
|
EP4587881A1
(en)
|
2022-09-13 |
2025-07-23 |
Augmedics Ltd. |
Augmented reality eyewear for image-guided medical intervention
|
|
WO2024064838A1
(en)
|
2022-09-21 |
2024-03-28 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
|
CA3265590A1
(en)
|
2022-09-28 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
MODIFIED ANTIBODY-RESISTANT RECEPTORS TO IMPROVE CELL-BASED THERAPIES
|
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
CN120693347A
(zh)
|
2022-11-04 |
2025-09-23 |
瑞泽恩制药公司 |
钙电压门控通道辅助亚基γ1(CACNG1)结合蛋白和CACNG1介导的向骨骼肌的递送
|
|
WO2024107765A2
(en)
|
2022-11-14 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
WO2024124044A1
(en)
|
2022-12-07 |
2024-06-13 |
The Brigham And Women’S Hospital, Inc. |
Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
|
|
EP4638766A1
(en)
|
2022-12-20 |
2025-10-29 |
NanoCell Therapeutics Holdings B.V. |
Integrating and self-inactivating viral vectors and constructs and uses thereof
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
WO2024155597A1
(en)
|
2023-01-17 |
2024-07-25 |
Inscripta, Inc. |
Methods and compositions of co-expression of t7rna polymerase and inhibitory rna aptamers
|
|
WO2024155830A2
(en)
*
|
2023-01-18 |
2024-07-25 |
Fred Hutchinson Cancer Center |
Viral particle producer cells with landing pad-integrated viral vectors
|
|
GB202300905D0
(en)
|
2023-01-20 |
2023-03-08 |
Nicoventures Trading Ltd |
Method
|
|
WO2024159071A1
(en)
|
2023-01-27 |
2024-08-02 |
Regeneron Pharmaceuticals, Inc. |
Modified rhabdovirus glycoproteins and uses thereof
|
|
WO2024163842A2
(en)
|
2023-02-03 |
2024-08-08 |
The Broad Institute, Inc. |
Delivering genes to the brain endothelium to treat lysosomal storage disorder-derived neuropathology
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
GB202303077D0
(en)
|
2023-03-02 |
2023-04-19 |
Univ Oslo |
Brassica plants with improved seed retention
|
|
WO2024192141A1
(en)
|
2023-03-13 |
2024-09-19 |
Dana-Farber Cancer Institute, Inc. |
Treatment of cancers having a drug-resistant mesenchymal cell state
|
|
KR20250163949A
(ko)
*
|
2023-03-20 |
2025-11-21 |
버브 테라퓨틱스, 인크. |
심혈관 질환의 치료를 위한 lpa 유전자의 생체내 닉카제-기반 편집
|
|
WO2024197185A1
(en)
|
2023-03-21 |
2024-09-26 |
The Broad Institute, Inc. |
Methods and compositions for dissecting organelle physiology
|
|
WO2024206911A2
(en)
|
2023-03-30 |
2024-10-03 |
Children's Hospital Medical Center |
Clinical-grade organoids
|
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
WO2024220574A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
TW202449159A
(zh)
|
2023-04-19 |
2024-12-16 |
美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 |
用於產生文庫之組合物及方法
|
|
WO2024226838A2
(en)
|
2023-04-25 |
2024-10-31 |
The Brigham And Women's Hospital, Inc. |
Treatment of autoimmune diseases having a pathogenic t cell state
|
|
CN121712899A
(zh)
*
|
2023-04-27 |
2026-03-20 |
伦斯勒理工学院 |
用于在真核细胞中准确插入dna序列的重组酶
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024238817A2
(en)
*
|
2023-05-16 |
2024-11-21 |
Fallon Jim Deceased |
Systems and methods for an intranasal drug delivery system
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
EP4713433A2
(en)
|
2023-05-18 |
2026-03-25 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
|
AU2024274792A1
(en)
|
2023-05-23 |
2025-10-23 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
|
CN121568725A
(zh)
|
2023-06-15 |
2026-02-24 |
里珍纳龙药品有限公司 |
用于听力病症的基因疗法
|
|
KR20260030105A
(ko)
|
2023-06-16 |
2026-03-05 |
에피제닉 테라퓨틱스 피티이 리미티드 |
B형 간염 바이러스 유전자를 표적으로 하는 후성유전학적 편집 도구
|
|
EP4731750A2
(en)
|
2023-06-23 |
2026-04-29 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
|
WO2025006419A1
(en)
|
2023-06-26 |
2025-01-02 |
Flagship Pioneering Innovations Vii, Llc |
Engineered plasmodia and related methods
|
|
KR20260032927A
(ko)
|
2023-06-30 |
2026-03-10 |
리제너론 파마슈티칼스 인코포레이티드 |
상동성 지향 복구를 증가시키는 방법 및 조성물
|
|
US20250049896A1
(en)
|
2023-07-28 |
2025-02-13 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:acid sphingomyelinase for treatment of acid sphingomyelinase deficiency
|
|
TW202513801A
(zh)
|
2023-07-28 |
2025-04-01 |
美商雷傑納榮製藥公司 |
用於治療龐貝氏症之抗ＴｆＲ：ＧＡＡ及抗ＣＤ６３：ＧＡＡ插入
|
|
KR20260046119A
(ko)
|
2023-07-28 |
2026-04-06 |
리제너론 파마슈티칼스 인코포레이티드 |
단방향 유전자 삽입 동안 도입유전자 발현을 증진시키는 bGH-SV40L 직렬 PolyA의 용도
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2025049524A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
|
WO2025049788A1
(en)
|
2023-08-29 |
2025-03-06 |
The Broad Institute, Inc. |
Optical genetic screens of intracellular and intercellular transcriptional circuits with perturb-fish
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025049959A2
(en)
|
2023-09-01 |
2025-03-06 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025059533A1
(en)
|
2023-09-13 |
2025-03-20 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2025064408A1
(en)
|
2023-09-18 |
2025-03-27 |
The Broad Institute, Inc. |
Compositions and methods for treating cardiovascular disease
|
|
WO2025064591A1
(en)
*
|
2023-09-19 |
2025-03-27 |
The Regents Of The University Of California |
In vivo gene editing of tau locus via liponanoparticle delivery
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025072383A1
(en)
|
2023-09-25 |
2025-04-03 |
The Broad Institute, Inc. |
Viral open reading frames, uses thereof, and methods of detecting the same
|
|
WO2025072803A1
(en)
|
2023-09-29 |
2025-04-03 |
Children's Hospital Medical Center |
Ntrk2 signaling-mediated alveolar capillary injury and repair
|
|
WO2025075911A1
(en)
|
2023-10-02 |
2025-04-10 |
Inscripta, Inc. |
Engineered gpp synthases
|
|
AU2024357861A1
(en)
|
2023-10-12 |
2026-04-23 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
WO2025085423A1
(en)
|
2023-10-19 |
2025-04-24 |
The Broad Institute, Inc. |
Method of multi-locus crispri targeting with a single truncated guide
|
|
WO2025097055A2
(en)
|
2023-11-02 |
2025-05-08 |
The Broad Institute, Inc. |
Compositions and methods of use of t cells in immunotherapy
|
|
WO2025096916A1
(en)
|
2023-11-03 |
2025-05-08 |
The Broad Institute, Inc. |
Multi-site editing in living cells
|
|
WO2025117544A1
(en)
|
2023-11-29 |
2025-06-05 |
The Broad Institute, Inc. |
Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof
|
|
WO2025129158A1
(en)
|
2023-12-15 |
2025-06-19 |
The Broad Institute, Inc. |
Engineered arc delivery vesicles and uses thereof
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025155923A1
(en)
|
2024-01-17 |
2025-07-24 |
The Broad Institute, Inc. |
Aav capsid modifications that enable improved cns-wide gene delivery through interactions with the transferrin receptor
|
|
WO2025155753A2
(en)
|
2024-01-17 |
2025-07-24 |
Renagade Therapeutics Management Inc. |
Improved gene editing system, guides, and methods
|
|
WO2025160155A1
(en)
|
2024-01-22 |
2025-07-31 |
The Broad Institute, Inc. |
Epigenetic targeting of prion diseases
|
|
WO2025166152A1
(en)
|
2024-02-02 |
2025-08-07 |
The Broad Institute, Inc. |
Multiplexed perturbation and decoding in pooled genetic screens
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
WO2025184567A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025212920A1
(en)
|
2024-04-03 |
2025-10-09 |
Children's Hospital Medical Center |
Multi-zonal liver organoids
|
|
WO2025211949A1
(ko)
*
|
2024-04-05 |
2025-10-09 |
재단법인대구경북과학기술원 |
ＳｅｒｐｉｎＡ１ｅ 단백질을 유효성분으로 포함하는 기억력, 인지기능 개선용 또는 뇌신경질환의 예방 또는 치료용 조성물
|
|
WO2025217163A2
(en)
|
2024-04-08 |
2025-10-16 |
The Broad Institute, Inc. |
Novel aav capsids binding to human cd59
|
|
WO2025217174A1
(en)
|
2024-04-08 |
2025-10-16 |
The Broad Institute, Inc. |
Aav capsid modifications that enable improved cns-wide gene delivery through interactions with carbonic anhydrase iv
|
|
WO2025217202A1
(en)
|
2024-04-08 |
2025-10-16 |
Children's Hospital Medical Center |
Bile duct organoid
|
|
WO2025217398A1
(en)
|
2024-04-10 |
2025-10-16 |
Lyell Immunopharma, Inc. |
Methods for culturing cells with improved culture medium
|
|
EP4677108A1
(en)
|
2024-04-22 |
2026-01-14 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
CN118376795B
(zh)
*
|
2024-05-10 |
2025-10-31 |
厦门大学 |
尿液中n-糖基化蛋白组合作为靶标在早期诊断阿尔茨海默病中的应用
|
|
WO2025244671A1
(en)
|
2024-05-22 |
2025-11-27 |
The Scripps Research Institute |
Compositions for use in treating haploinsufficiency diseases
|
|
WO2025250808A1
(en)
|
2024-05-29 |
2025-12-04 |
The Brigham And Women’S Hospital, Inc. |
Anti-crispr delivery compositions and methods
|
|
WO2025259669A1
(en)
|
2024-06-10 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for characterizing modified oligonucleotides
|
|
WO2025265017A1
(en)
|
2024-06-20 |
2025-12-26 |
Regeneron Pharmaceuticals, Inc. |
Ass1 gene insertion for the treatment of citrullinemia type i
|
|
WO2026006542A2
(en)
|
2024-06-26 |
2026-01-02 |
Yale University |
Compositions and methods for crispr/cas9 based reactivation of human angelman syndrome
|
|
WO2026047626A1
(en)
|
2024-08-30 |
2026-03-05 |
Inceptor Bio, Llc |
Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy
|
|
WO2026064425A2
(en)
|
2024-09-17 |
2026-03-26 |
Dxome Co., Ltd. |
Mirror image crispr-cas compositions
|
|
WO2026072529A1
(en)
|
2024-09-24 |
2026-04-02 |
University Of Florida Research Foundation, Incorporated |
Mettl7a for improved embryo competence
|
|
WO2026072952A2
(en)
|
2024-09-27 |
2026-04-02 |
New England Biolabs, Inc. |
Cas12a compositions and methods
|
|
WO2026080515A2
(en)
|
2024-10-08 |
2026-04-16 |
Regeneron Pharmaceuticals, Inc. |
Crispr sam biosensor cells and cell lines and methods of use thereof
|
|
CN119570025A
(zh)
*
|
2024-11-19 |
2025-03-07 |
中国药科大学 |
一种聚乙烯亚胺衍生物及其作为基因药物载体应用
|
|
CN121276067B
(zh)
*
|
2025-12-08 |
2026-03-24 |
首都医科大学附属北京地坛医院 |
一种预测乙型肝炎相关肝衰竭患者继发感染的蛋白质组合、试剂盒及系统
|