|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
US9458450B2
(en)
|
2012-03-15 |
2016-10-04 |
Flodesign Sonics, Inc. |
Acoustophoretic separation technology using multi-dimensional standing waves
|
|
US10967298B2
(en)
|
2012-03-15 |
2021-04-06 |
Flodesign Sonics, Inc. |
Driver and control for variable impedence load
|
|
US9950282B2
(en)
|
2012-03-15 |
2018-04-24 |
Flodesign Sonics, Inc. |
Electronic configuration and control for acoustic standing wave generation
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
CA2935960C
(en)
|
2014-01-08 |
2023-01-10 |
Bart Lipkens |
Acoustophoresis device with dual acoustophoretic chamber
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
US11021699B2
(en)
|
2015-04-29 |
2021-06-01 |
FioDesign Sonics, Inc. |
Separation using angled acoustic waves
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
US11459540B2
(en)
|
2015-07-28 |
2022-10-04 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
US11474085B2
(en)
|
2015-07-28 |
2022-10-18 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
|
GB2557123B
(en)
|
2015-07-31 |
2021-11-03 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
SG10202104041PA
(en)
|
2015-10-23 |
2021-06-29 |
Harvard College |
Nucleobase editors and uses thereof
|
|
WO2017184674A1
(en)
*
|
2016-04-19 |
2017-10-26 |
President And Fellows Of Harvard College |
Methods for increasing efficiency of nuclease-mediated gene editing in stem cells
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
US11085035B2
(en)
|
2016-05-03 |
2021-08-10 |
Flodesign Sonics, Inc. |
Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
|
|
KR20250103795A
(ko)
|
2016-08-03 |
2025-07-07 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
SG11201903089RA
(en)
|
2016-10-14 |
2019-05-30 |
Harvard College |
Aav delivery of nucleobase editors
|
|
GB2573406B
(en)
|
2016-10-18 |
2021-11-10 |
Univ Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
CN110494543A
(zh)
|
2016-10-19 |
2019-11-22 |
弗洛设计声能学公司 |
通过声学的亲和细胞提取
|
|
CN111344396A
(zh)
*
|
2016-10-27 |
2020-06-26 |
因提玛生物科学公司 |
制备遗传修饰细胞的病毒方法
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CN107760680B
(zh)
*
|
2016-12-28 |
2020-09-22 |
北京微旋基因技术有限公司 |
特异性靶向TIM-3基因的sgRNA和特异性敲除TIM-3基因的方法
|
|
CN107746845B
(zh)
*
|
2016-12-28 |
2021-03-26 |
北京微旋基因技术有限公司 |
特异性靶向LAG-3基因的sgRNA和特异性敲除LAG-3基因的方法
|
|
EP3592381A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Cancer vaccine
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
WO2018165629A1
(en)
|
2017-03-10 |
2018-09-13 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
|
CN108866100A
(zh)
*
|
2017-05-16 |
2018-11-23 |
中国科学院上海生命科学研究院 |
一种高效率的基因编辑方法
|
|
JP2020530307A
(ja)
|
2017-06-30 |
2020-10-22 |
インティマ・バイオサイエンス,インコーポレーテッド |
遺伝子治療のためのアデノ随伴ウイルスベクター
|
|
CA3067914A1
(en)
|
2017-06-30 |
2019-01-03 |
Cellectis |
Cellular immunotherapy for repetitive administration
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
US11795443B2
(en)
|
2017-10-16 |
2023-10-24 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
ES2998052T3
(en)
*
|
2017-10-24 |
2025-02-18 |
Editas Medicine Inc |
Systems and methods for treating hyper-igm syndrome
|
|
SG11202003907WA
(en)
|
2017-12-14 |
2020-05-28 |
Flodesign Sonics Inc |
Acoustic transducer drive and controller
|
|
WO2019118949A1
(en)
|
2017-12-15 |
2019-06-20 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
US20190284553A1
(en)
|
2018-03-15 |
2019-09-19 |
KSQ Therapeutics, Inc. |
Gene-regulating compositions and methods for improved immunotherapy
|
|
US20210071202A1
(en)
*
|
2018-03-29 |
2021-03-11 |
Jichi Medical University |
Genome editing method, composition, cell, cell preparation, and method for producing cell preparation
|
|
US20210324381A1
(en)
*
|
2018-04-27 |
2021-10-21 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Therapeutic genome editing in x-linked hyper igm syndrome
|
|
EP3794130A4
(en)
|
2018-05-16 |
2022-07-27 |
Synthego Corporation |
METHODS AND SYSTEMS FOR DESIGNING AND USING GUIDE RNA
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CA3101477A1
(en)
*
|
2018-05-30 |
2019-12-05 |
M2X2 Therapeutics, Inc. |
Cell therapy
|
|
CN112601812A
(zh)
*
|
2018-06-25 |
2021-04-02 |
圣拉斐尔医院有限责任公司 |
基因疗法
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
CN109528653B
(zh)
*
|
2018-11-22 |
2020-07-31 |
北京大学 |
具有基因编辑功能的膜性囊泡及其制备方法、药物组合物和用途
|
|
CN109735516B
(zh)
*
|
2019-01-22 |
2021-09-03 |
自然资源部第一海洋研究所 |
受核苷酸片段引导具有特异核酸内切酶活性的piwi蛋白
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
EP3942043A2
(en)
|
2019-03-19 |
2022-01-26 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
CN111812066B
(zh)
*
|
2019-04-10 |
2023-04-28 |
华东理工大学 |
基于CRISPR/Cas12a系统的生物传感器、试剂盒及其在小分子检测中的用途
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
BR112022022603A2
(pt)
|
2020-05-08 |
2023-01-17 |
Broad Inst Inc |
Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla
|
|
CN111909961B
(zh)
*
|
2020-08-21 |
2022-04-19 |
华侨大学 |
一种CRISPR/Cas介导的ATL细胞基因编辑载体及其应用
|
|
EP4262850A4
(en)
*
|
2020-12-21 |
2025-07-09 |
Novo Nordisk As |
COMPOSITIONS AND METHODS FOR SITE-DIRECTED MUTAGENESIS
|
|
EP4288088A2
(en)
*
|
2021-02-08 |
2023-12-13 |
Intellia Therapeutics, Inc. |
Lymphocyte activation gene 3 (lag3) compositions and methods for immunotherapy
|
|
JP2024506016A
(ja)
*
|
2021-02-08 |
2024-02-08 |
インテリア セラピューティクス,インコーポレイテッド |
免疫療法のためのt細胞免疫グロブリン及びムチンドメイン3(tim3)組成物及び方法
|
|
MX2023010969A
(es)
*
|
2021-03-19 |
2023-09-27 |
Metagenomi Inc |
Edicion multiplex con enzimas cas.
|
|
CN113481184A
(zh)
*
|
2021-08-06 |
2021-10-08 |
北京大学 |
融合蛋白以及其使用方法
|
|
JP2024534114A
(ja)
*
|
2021-08-24 |
2024-09-18 |
インテリア セラピューティクス,インコーポレイテッド |
細胞療法用のプログラム細胞死タンパク質1(pd1)組成物及び方法
|
|
EP4441078A4
(en)
*
|
2021-12-03 |
2025-11-19 |
Massachusetts Gen Hospital |
CRISPR-associated transposes and their methods of use
|
|
WO2023122036A1
(en)
*
|
2021-12-20 |
2023-06-29 |
Sobol Robert E |
Methods and compositions for improved molecular therapies of multigenic diseases
|
|
EP4590818A2
(en)
*
|
2022-09-19 |
2025-07-30 |
Emendobio Inc. |
Biallelic knockout of pdcd1
|
|
WO2024102954A1
(en)
|
2022-11-10 |
2024-05-16 |
Massachusetts Institute Of Technology |
Activation induced clipping system (aics)
|
|
WO2024107119A1
(en)
*
|
2022-11-17 |
2024-05-23 |
Agency For Science, Technology And Research |
T3 vectors for recombinant protein production in mammalian cells
|
|
CN117987436B
(zh)
*
|
2024-04-03 |
2024-06-25 |
南京鸿明生物科技有限公司 |
一种双链靶dna序列的制备方法
|
|
WO2025235862A1
(en)
|
2024-05-10 |
2025-11-13 |
Inndura Therapeutics Inc. |
A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a
|