JP2013507935A5 - - Google Patents
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- Publication number
- JP2013507935A5 JP2013507935A5 JP2012534414A JP2012534414A JP2013507935A5 JP 2013507935 A5 JP2013507935 A5 JP 2013507935A5 JP 2012534414 A JP2012534414 A JP 2012534414A JP 2012534414 A JP2012534414 A JP 2012534414A JP 2013507935 A5 JP2013507935 A5 JP 2013507935A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- essential
- seq
- mva virus
- orf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 21
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 20
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108700026244 Open Reading Frames Proteins 0.000 claims 8
- 108091026890 Coding region Proteins 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091029795 Intergenic region Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 208000007089 vaccinia Diseases 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 101710091045 Envelope protein Proteins 0.000 claims 1
- 108700039887 Essential Genes Proteins 0.000 claims 1
- 101710188315 Protein X Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25232609P | 2009-10-16 | 2009-10-16 | |
| US61/252,326 | 2009-10-16 | ||
| PCT/US2010/052929 WO2011047324A1 (en) | 2009-10-16 | 2010-10-15 | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507935A JP2013507935A (ja) | 2013-03-07 |
| JP2013507935A5 true JP2013507935A5 (enExample) | 2013-10-31 |
| JP5789263B2 JP5789263B2 (ja) | 2015-10-07 |
Family
ID=43297031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534414A Active JP5789263B2 (ja) | 2009-10-16 | 2010-10-15 | 再構築された挿入部位を含有する組換え改変ワクシニアアンカラ（ｍｖａ）ワクシニアウイルス |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9133480B2 (enExample) |
| EP (1) | EP2488649B1 (enExample) |
| JP (1) | JP5789263B2 (enExample) |
| AU (1) | AU2010306559B2 (enExample) |
| CA (1) | CA2777744C (enExample) |
| DK (1) | DK2488649T3 (enExample) |
| WO (1) | WO2011047324A1 (enExample) |
| ZA (1) | ZA201203551B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008142479A2 (en) * | 2006-08-25 | 2008-11-27 | The Government Of The United States Of Amercia, As Represented By The Secretary, Department Of Health And Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
| US8580276B2 (en) | 2009-06-05 | 2013-11-12 | City Of Hope | Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof |
| AU2010306559B2 (en) | 2009-10-16 | 2015-07-16 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services . | Recombinant modified vaccinia Ankara (MVA) vaccinia virus containing restructured insertion sites |
| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| AU2015320409B2 (en) | 2014-09-26 | 2019-03-28 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Virus-based expression vectors and uses thereof |
| US11701418B2 (en) | 2015-01-12 | 2023-07-18 | Geovax, Inc. | Replication-deficient modified vaccinia Ankara (MVA) expressing Ebola virus glycoprotein (GP) and matrix protein (VP40) |
| US20190038659A1 (en) | 2015-09-29 | 2019-02-07 | The Usa, As Represented By The Secretary, Department Of Health And Human Services | Methods of treating and preventing amyotrophic lateral sclerosis |
| CA3011014A1 (en) | 2016-01-08 | 2017-07-13 | Geovax, Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| WO2017136419A1 (en) * | 2016-02-03 | 2017-08-10 | Geovax Inc. | Compositions and methods for generating an immune response to a flavivirus |
| WO2017210181A1 (en) * | 2016-05-30 | 2017-12-07 | Geovax Inc. | Compositions and methods for generating an immune response to hepatitis b virus |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| WO2019152746A2 (en) | 2018-01-30 | 2019-08-08 | Emory University | Compositions and methods for promoting immune responses to human immunodeficiency virus |
| WO2019217922A1 (en) | 2018-05-11 | 2019-11-14 | City Of Hope | Genetically modified recombinant vaccinia ankara (rmva) vaccines of improved stability and methods of preparation thereof |
| KR20220011685A (ko) | 2019-05-22 | 2022-01-28 | 길리애드 사이언시즈, 인코포레이티드 | Tlr7 조절 화합물과 hiv 백신의 조합 |
| CA3156346A1 (en) * | 2019-10-02 | 2021-04-08 | Bionoxx Inc. | Tumor-targeting protein or fragment thereof, antibody binding thereto and use thereof |
| EP4058058A1 (en) | 2019-11-14 | 2022-09-21 | Aelix Therapeutics S.L. | Dosage regimens for vaccines |
| IL295482A (en) | 2020-02-14 | 2022-10-01 | Geovax Inc | Vaccines and their uses to induce an immune response to sars-cov2 |
| EP4153228A4 (en) | 2020-05-17 | 2024-07-10 | City of Hope | CORONAVIRUS VACCINES BASED ON SYNTHETIC MODIFIED ANKARA VACCINE (SMVA) VIRUS |
| CA3206004A1 (en) | 2021-02-02 | 2022-08-11 | Mary Jo Hauser | Viral constructs for use in enhancing t-cell priming during vaccination |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL218318B1 (pl) | 2002-05-16 | 2014-11-28 | Bavarian Nordic As | Rekombinowany wirus krowianki Ankara (MVA), zawierająca go komórka, szczepionka lub kompozycja farmaceutyczna, sposób lub zestaw do jego otrzymywania, sekwencja DNA zawierająca genom tego wirusa oraz sposób wykrywania tego wirusa lub komórek nim zainfekowanych |
| EP1610816B1 (en) | 2003-03-28 | 2013-01-02 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Mva virus expressing modified hiv envelope, gag, and pol genes |
| WO2008142479A2 (en) * | 2006-08-25 | 2008-11-27 | The Government Of The United States Of Amercia, As Represented By The Secretary, Department Of Health And Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
| EP2199400A1 (en) * | 2008-12-22 | 2010-06-23 | Emergent Product Development Germany GmbH | Single recombination system and methods of use |
| AU2010306559B2 (en) | 2009-10-16 | 2015-07-16 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services . | Recombinant modified vaccinia Ankara (MVA) vaccinia virus containing restructured insertion sites |
-
2010
- 2010-10-15 AU AU2010306559A patent/AU2010306559B2/en active Active
- 2010-10-15 CA CA2777744A patent/CA2777744C/en active Active
- 2010-10-15 JP JP2012534414A patent/JP5789263B2/ja active Active
- 2010-10-15 DK DK10771611.0T patent/DK2488649T3/da active
- 2010-10-15 WO PCT/US2010/052929 patent/WO2011047324A1/en not_active Ceased
- 2010-10-15 US US13/502,205 patent/US9133480B2/en active Active
- 2010-10-15 EP EP10771611.0A patent/EP2488649B1/en active Active
-
2012
- 2012-05-15 ZA ZA2012/03551A patent/ZA201203551B/en unknown
-
2015
- 2015-08-27 US US14/837,382 patent/US9879231B2/en active Active
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