JP2013507935A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013507935A5 JP2013507935A5 JP2012534414A JP2012534414A JP2013507935A5 JP 2013507935 A5 JP2013507935 A5 JP 2013507935A5 JP 2012534414 A JP2012534414 A JP 2012534414A JP 2012534414 A JP2012534414 A JP 2012534414A JP 2013507935 A5 JP2013507935 A5 JP 2013507935A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- essential
- seq
- mva virus
- orf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 21
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 20
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108700026244 Open Reading Frames Proteins 0.000 claims 8
- 108091026890 Coding region Proteins 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091029795 Intergenic region Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 208000007089 vaccinia Diseases 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 101710091045 Envelope protein Proteins 0.000 claims 1
- 108700039887 Essential Genes Proteins 0.000 claims 1
- 101710188315 Protein X Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25232609P | 2009-10-16 | 2009-10-16 | |
| US61/252,326 | 2009-10-16 | ||
| PCT/US2010/052929 WO2011047324A1 (en) | 2009-10-16 | 2010-10-15 | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507935A JP2013507935A (ja) | 2013-03-07 |
| JP2013507935A5 true JP2013507935A5 (enExample) | 2013-10-31 |
| JP5789263B2 JP5789263B2 (ja) | 2015-10-07 |
Family
ID=43297031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534414A Active JP5789263B2 (ja) | 2009-10-16 | 2010-10-15 | 再構築された挿入部位を含有する組換え改変ワクシニアアンカラ（ｍｖａ）ワクシニアウイルス |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9133480B2 (enExample) |
| EP (1) | EP2488649B1 (enExample) |
| JP (1) | JP5789263B2 (enExample) |
| AU (1) | AU2010306559B2 (enExample) |
| CA (1) | CA2777744C (enExample) |
| DK (1) | DK2488649T3 (enExample) |
| WO (1) | WO2011047324A1 (enExample) |
| ZA (1) | ZA201203551B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2062023B2 (en) * | 2006-08-25 | 2016-11-09 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
| US8580276B2 (en) | 2009-06-05 | 2013-11-12 | City Of Hope | Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof |
| DK2488649T3 (da) | 2009-10-16 | 2019-06-17 | Us Health | Rekombinant modificeret vaccinia ankara (mva)-vaccinia-virus indeholdende restrukturerede insertionssteder |
| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| AU2015320409B2 (en) | 2014-09-26 | 2019-03-28 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Virus-based expression vectors and uses thereof |
| WO2016115116A1 (en) | 2015-01-12 | 2016-07-21 | Geovax, Inc. | Compositions and methods for generating an immune response to a hemorrhagic fever virus |
| US20190038659A1 (en) | 2015-09-29 | 2019-02-07 | The Usa, As Represented By The Secretary, Department Of Health And Human Services | Methods of treating and preventing amyotrophic lateral sclerosis |
| ES2944314T3 (es) * | 2016-01-08 | 2023-06-20 | Geovax Inc | Composiciones y procedimientos para generar una respuesta inmunitaria frente a un antígeno asociado a un tumor |
| US20190030157A1 (en) | 2016-02-03 | 2019-01-31 | Geovax Inc. | Compositions and Methods for Generating an Immune Response to a Flavivirus |
| CA3026054A1 (en) * | 2016-05-30 | 2017-12-07 | Geovax Inc. | Compositions and methods for generating an immune response to hepatitis b virus |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| US11590219B2 (en) | 2018-01-30 | 2023-02-28 | Emory University | Compositions and methods for promoting immune responses to human immunodeficiency virus |
| JP2021523712A (ja) | 2018-05-11 | 2021-09-09 | シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ | 安定性が改善された遺伝子組み換え組換えワクシニアアンカラ（ｒｍｖａ）ワクチン及びその調製方法 |
| EP4043482A4 (en) * | 2019-10-02 | 2024-03-13 | Bionoxx Inc. | TUMOR TARGETING PROTEIN OR ASSOCIATED FRAGMENT, ANTIBODIES BINDING THEREWITH AND ITS USE |
| AU2020384323A1 (en) | 2019-11-14 | 2022-06-02 | Aelix Therapeutics, S.L. | Dosage regimens for vaccines |
| KR20220154114A (ko) | 2020-02-14 | 2022-11-21 | 지오박스, 인크. | 백신 및 SARS-CoV2에 대한 면역 반응을 유도하기 위한 그의 용도 |
| JP2024505274A (ja) | 2021-02-02 | 2024-02-05 | ゲオバックス インコーポレイテッド | ワクチン接種中のｔ細胞プライミングの強化において使用されるウイルスコンストラクト |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101138067B1 (ko) | 2002-05-16 | 2012-04-24 | 버베리안 노딕 에이/에스 | 수두 바이러스 게놈내로 삽입된 상동 유전자를 발현하는 재조합 수두 바이러스 |
| EP2363143A3 (en) | 2003-03-28 | 2012-02-15 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | MVA expressing modified hiv envelope, gag, and pol genes |
| EP2062023B2 (en) * | 2006-08-25 | 2016-11-09 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
| EP2199400A1 (en) | 2008-12-22 | 2010-06-23 | Emergent Product Development Germany GmbH | Single recombination system and methods of use |
| DK2488649T3 (da) | 2009-10-16 | 2019-06-17 | Us Health | Rekombinant modificeret vaccinia ankara (mva)-vaccinia-virus indeholdende restrukturerede insertionssteder |
-
2010
- 2010-10-15 DK DK10771611.0T patent/DK2488649T3/da active
- 2010-10-15 CA CA2777744A patent/CA2777744C/en active Active
- 2010-10-15 AU AU2010306559A patent/AU2010306559B2/en active Active
- 2010-10-15 WO PCT/US2010/052929 patent/WO2011047324A1/en not_active Ceased
- 2010-10-15 US US13/502,205 patent/US9133480B2/en active Active
- 2010-10-15 EP EP10771611.0A patent/EP2488649B1/en active Active
- 2010-10-15 JP JP2012534414A patent/JP5789263B2/ja active Active
-
2012
- 2012-05-15 ZA ZA2012/03551A patent/ZA201203551B/en unknown
-
2015
- 2015-08-27 US US14/837,382 patent/US9879231B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013507935A5 (enExample) | ||
| Yang et al. | Pervasive initiation and 3′-end formation of poxvirus postreplicative RNAs | |
| JP2011004755A5 (enExample) | ||
| JP2010259446A5 (enExample) | ||
| HRP20180146T1 (hr) | Vektori i sljedovi namijenjeni liječenju bolesti | |
| JP2014516536A5 (enExample) | ||
| JP2012509678A5 (enExample) | ||
| RU2018122636A (ru) | Стабильные клеточные линии для продуцирования ретровирусов | |
| CN105861558A (zh) | 一种痘苗病毒穿梭载体及其制备方法和应用 | |
| Flick et al. | Functional analysis of the noncoding regions of the Uukuniemi virus (Bunyaviridae) RNA segments | |
| JP2013538554A5 (enExample) | ||
| JP2012531205A5 (enExample) | ||
| CN118234850A (zh) | 利用微rna来下调经修饰的安卡拉痘苗病毒(mva)的细胞毒性转基因的表达 | |
| CN104195154B (zh) | 新城疫病毒Mukteswar中等毒力疫苗株反向遗传操作系统及其应用 | |
| CN105274142B (zh) | 复制型重组人55型腺病毒载体及其制备方法和应用 | |
| CN106755089A (zh) | 表达山羊淋巴细胞活化分子的细胞系及其构建方法与应用 | |
| CA2909225C (en) | Mutant vaccinia virus strains, uses thereof and method of producing the same | |
| RU2011137404A (ru) | Варианты гемагглютинина и нейраминидазы гриппа | |
| CN113736799B (zh) | 山羊副流感病毒3型感染性cDNA克隆构建方法及其应用 | |
| RU2014129220A (ru) | Новый аттенуированный полиовирус: pv-1 mono-cre-x | |
| US20080267992A1 (en) | Sars Virus Vaccine with Adenovirus Carrier and Preparation Method Thereof, and Use of Sars Virus S Gene for Preparation of Vaccine | |
| CN101402945A (zh) | 表达抗传染性法氏囊病病毒微小rna重组禽腺联病毒的制备方法 | |
| CN104789598B (zh) | 一种表达红色荧光蛋白的重组家蚕质型多角体病毒的构建方法 | |
| CN117511888A (zh) | 一种基于CRISPR-Cas9技术的表达鸡传染性贫血病病毒T1P6毒株VP2蛋白的重组血清4型禽腺病毒及其制备方法 | |
| KR101677231B1 (ko) | 무혈청배지（serum free medium）를 이용한 메갈로사이티바이러스의 효율적 제조방법 |