JP2012531205A5 - - Google Patents
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- Publication number
- JP2012531205A5 JP2012531205A5 JP2012517731A JP2012517731A JP2012531205A5 JP 2012531205 A5 JP2012531205 A5 JP 2012531205A5 JP 2012517731 A JP2012517731 A JP 2012517731A JP 2012517731 A JP2012517731 A JP 2012517731A JP 2012531205 A5 JP2012531205 A5 JP 2012531205A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza virus
- polypeptide
- recombinant
- amino acid
- reassortant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000712461 unidentified influenza virus Species 0.000 claims 41
- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 102000005348 Neuraminidase Human genes 0.000 claims 10
- 108010006232 Neuraminidase Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 3
- 230000002238 attenuated effect Effects 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 229960003971 influenza vaccine Drugs 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 241000725681 Swine influenza virus Species 0.000 claims 1
- 230000006978 adaptation Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22042609P | 2009-06-25 | 2009-06-25 | |
| US61/220,426 | 2009-06-25 | ||
| US22798609P | 2009-07-23 | 2009-07-23 | |
| US61/227,986 | 2009-07-23 | ||
| US23402109P | 2009-08-14 | 2009-08-14 | |
| US61/234,021 | 2009-08-14 | ||
| US25889009P | 2009-11-06 | 2009-11-06 | |
| US61/258,890 | 2009-11-06 | ||
| PCT/US2010/039826 WO2010151673A1 (en) | 2009-06-25 | 2010-06-24 | Swine influenza hemagglutinin variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012531205A JP2012531205A (ja) | 2012-12-10 |
| JP2012531205A5 true JP2012531205A5 (enExample) | 2013-06-13 |
| JP5745511B2 JP5745511B2 (ja) | 2015-07-08 |
Family
ID=43386887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517731A Expired - Fee Related JP5745511B2 (ja) | 2009-06-25 | 2010-06-24 | ブタインフルエンザヘマグルチニン変異体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8088393B2 (enExample) |
| EP (1) | EP2448598B1 (enExample) |
| JP (1) | JP5745511B2 (enExample) |
| KR (1) | KR20120101318A (enExample) |
| CN (1) | CN102802666B (enExample) |
| AU (2) | AU2010266078B2 (enExample) |
| BR (1) | BRPI1014844A2 (enExample) |
| CA (1) | CA2766377A1 (enExample) |
| MX (1) | MX2012000123A (enExample) |
| NZ (2) | NZ596823A (enExample) |
| RU (1) | RU2560420C2 (enExample) |
| SG (2) | SG176178A1 (enExample) |
| WO (1) | WO2010151673A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010151673A1 (en) | 2009-06-25 | 2010-12-29 | Medimmune, Llc | Swine influenza hemagglutinin variants |
| JP2015501141A (ja) * | 2011-10-07 | 2015-01-15 | メディミューン，エルエルシー | インフルエンザヘマグルチニン変異体 |
| KR101315273B1 (ko) * | 2012-10-29 | 2013-10-08 | 대한민국 | 강독화된 인플루엔자 바이러스 변이주 |
| EP2925356A2 (en) * | 2012-12-03 | 2015-10-07 | Novartis AG | Reassortant influenza a viren |
| SG11201609207SA (en) * | 2014-05-13 | 2016-12-29 | Univ Pennsylvania | Compositions comprising aav expressing dual antibody constructs and uses thereof |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN108135994B (zh) | 2015-05-13 | 2022-01-25 | 宾夕法尼亚州大学信托人 | Aav-介导的抗-流感抗体的表达及其使用方法 |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
| SG11201907611WA (en) | 2017-02-28 | 2019-09-27 | Univ Pennsylvania | Influenza vaccines based on aav vectors |
| RU2020124143A (ru) | 2017-12-22 | 2022-01-24 | Кодадженикс Инк. | Рекомбинантный вирус с областью деоптимизированной пары кодонов и его применение для лечения рака |
| BR112020018188A2 (pt) | 2018-03-08 | 2021-02-02 | Codagenix Inc. | flavivírus atenuados |
| WO2025081053A1 (en) * | 2023-10-11 | 2025-04-17 | Flugen, Inc. | Formulations for thermostable vaccines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| EP1945778B1 (en) * | 2005-10-17 | 2012-12-26 | MedImmune, LLC | Methods of increasing influenza virus replication |
| JP2010500034A (ja) * | 2006-08-09 | 2010-01-07 | メッドイミューン バクシーンズ，インコーポレイティド | インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体 |
| WO2008145129A2 (en) | 2007-05-31 | 2008-12-04 | Statens Serum Institut | Influenza vaccines |
| WO2010151673A1 (en) | 2009-06-25 | 2010-12-29 | Medimmune, Llc | Swine influenza hemagglutinin variants |
-
2010
- 2010-06-24 WO PCT/US2010/039826 patent/WO2010151673A1/en not_active Ceased
- 2010-06-24 US US12/822,781 patent/US8088393B2/en not_active Expired - Fee Related
- 2010-06-24 NZ NZ596823A patent/NZ596823A/xx not_active IP Right Cessation
- 2010-06-24 SG SG2011085669A patent/SG176178A1/en unknown
- 2010-06-24 EP EP10792667.7A patent/EP2448598B1/en not_active Not-in-force
- 2010-06-24 RU RU2012102385/10A patent/RU2560420C2/ru not_active IP Right Cessation
- 2010-06-24 KR KR1020127000803A patent/KR20120101318A/ko not_active Ceased
- 2010-06-24 CA CA2766377A patent/CA2766377A1/en not_active Abandoned
- 2010-06-24 AU AU2010266078A patent/AU2010266078B2/en not_active Ceased
- 2010-06-24 NZ NZ617191A patent/NZ617191A/en not_active IP Right Cessation
- 2010-06-24 JP JP2012517731A patent/JP5745511B2/ja not_active Expired - Fee Related
- 2010-06-24 CN CN201080027726.4A patent/CN102802666B/zh not_active Expired - Fee Related
- 2010-06-24 BR BRPI1014844A patent/BRPI1014844A2/pt not_active IP Right Cessation
- 2010-06-24 SG SG10201403557QA patent/SG10201403557QA/en unknown
- 2010-06-24 MX MX2012000123A patent/MX2012000123A/es not_active Application Discontinuation
-
2011
- 2011-12-01 US US13/308,809 patent/US8715691B2/en not_active Expired - Fee Related
-
2014
- 2014-06-25 AU AU2014203458A patent/AU2014203458A1/en not_active Abandoned
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