AU2010266078B2 - Swine influenza hemagglutinin variants - Google Patents

Swine influenza hemagglutinin variants Download PDF

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Publication number
AU2010266078B2
AU2010266078B2 AU2010266078A AU2010266078A AU2010266078B2 AU 2010266078 B2 AU2010266078 B2 AU 2010266078B2 AU 2010266078 A AU2010266078 A AU 2010266078A AU 2010266078 A AU2010266078 A AU 2010266078A AU 2010266078 B2 AU2010266078 B2 AU 2010266078B2
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AU
Australia
Prior art keywords
virus
reassortant
influenza
amino acid
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010266078A
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English (en)
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AU2010266078A1 (en
Inventor
Hong Jin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune LLC
Original Assignee
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune LLC filed Critical MedImmune LLC
Publication of AU2010266078A1 publication Critical patent/AU2010266078A1/en
Priority to AU2014203458A priority Critical patent/AU2014203458A1/en
Application granted granted Critical
Publication of AU2010266078B2 publication Critical patent/AU2010266078B2/en
Priority to AU2014240376A priority patent/AU2014240376A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151Methods of production or purification of viral material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171Demonstrated in vivo effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2010266078A 2009-06-25 2010-06-24 Swine influenza hemagglutinin variants Ceased AU2010266078B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2014203458A AU2014203458A1 (en) 2009-06-25 2014-06-25 Swine influenza hemagglutinin variants
AU2014240376A AU2014240376A1 (en) 2009-06-25 2014-10-09 Swine influenza hemagglutinin variants

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US22042609P 2009-06-25 2009-06-25
US61/220,426 2009-06-25
US22798609P 2009-07-23 2009-07-23
US61/227,986 2009-07-23
US23402109P 2009-08-14 2009-08-14
US61/234,021 2009-08-14
US25889009P 2009-11-06 2009-11-06
US61/258,890 2009-11-06
PCT/US2010/039826 WO2010151673A1 (en) 2009-06-25 2010-06-24 Swine influenza hemagglutinin variants

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2014203458A Division AU2014203458A1 (en) 2009-06-25 2014-06-25 Swine influenza hemagglutinin variants
AU2014240376A Division AU2014240376A1 (en) 2009-06-25 2014-10-09 Swine influenza hemagglutinin variants

Publications (2)

Publication Number Publication Date
AU2010266078A1 AU2010266078A1 (en) 2011-12-22
AU2010266078B2 true AU2010266078B2 (en) 2014-08-14

Family

ID=43386887

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2010266078A Ceased AU2010266078B2 (en) 2009-06-25 2010-06-24 Swine influenza hemagglutinin variants
AU2014203458A Abandoned AU2014203458A1 (en) 2009-06-25 2014-06-25 Swine influenza hemagglutinin variants

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2014203458A Abandoned AU2014203458A1 (en) 2009-06-25 2014-06-25 Swine influenza hemagglutinin variants

Country Status (13)

Country Link
US (2) US8088393B2 (enExample)
EP (1) EP2448598B1 (enExample)
JP (1) JP5745511B2 (enExample)
KR (1) KR20120101318A (enExample)
CN (1) CN102802666B (enExample)
AU (2) AU2010266078B2 (enExample)
BR (1) BRPI1014844A2 (enExample)
CA (1) CA2766377A1 (enExample)
MX (1) MX2012000123A (enExample)
NZ (2) NZ617191A (enExample)
RU (1) RU2560420C2 (enExample)
SG (2) SG176178A1 (enExample)
WO (1) WO2010151673A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010151673A1 (en) 2009-06-25 2010-12-29 Medimmune, Llc Swine influenza hemagglutinin variants
HK1200845A1 (en) * 2011-10-07 2015-08-14 Medimmune, Llc Influenza hemagglutinin variants
KR101315273B1 (ko) * 2012-10-29 2013-10-08 대한민국 강독화된 인플루엔자 바이러스 변이주
CA2893429A1 (en) * 2012-12-03 2014-06-12 Synthetic Genomics Vaccines, Inc. Influenza virus reassortment
PT3142750T (pt) * 2014-05-13 2020-09-22 Univ Pennsylvania Composições que compreendem aav expressando construções de anticorpos duplos e suas utilizações
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
MA48852A (fr) 2015-05-13 2020-04-01 Univ Pennsylvania Expression médiée par aav d'anticorps anti-grippaux et leurs procédés d'utilisation
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2018160573A1 (en) 2017-02-28 2018-09-07 The Trustees Of The University Of Pennsylvania Influenza vaccines based on aav vectors
JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
WO2018160582A1 (en) 2017-02-28 2018-09-07 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) clade f vector and uses therefor
MX2020006530A (es) 2017-12-22 2020-10-15 Codagenix Inc Virus recombinante con region desoptimizada de par de codones y usos del mismo para el tratamiento de cancer.
CA3091508A1 (en) 2018-03-08 2019-09-12 Codagenix Inc. Attenuated flaviviruses
WO2025081053A1 (en) * 2023-10-11 2025-04-17 Flugen, Inc. Formulations for thermostable vaccines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
JP5349049B2 (ja) * 2005-10-17 2013-11-20 メディミューン,エルエルシー インフルエンザウイルス製造用マルチプラスミド系
JP2010500034A (ja) * 2006-08-09 2010-01-07 メッドイミューン バクシーンズ,インコーポレイティド インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体
EP2160198A2 (en) * 2007-05-31 2010-03-10 Statens Serum Institut Influenza vaccines
WO2010151673A1 (en) 2009-06-25 2010-12-29 Medimmune, Llc Swine influenza hemagglutinin variants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
UniProtKB C3W5X2_9INFA, http://www.uniprot.org/uniprot/C3W5X2.txt?version=1 *

Also Published As

Publication number Publication date
JP5745511B2 (ja) 2015-07-08
AU2010266078A1 (en) 2011-12-22
RU2560420C2 (ru) 2015-08-20
RU2012102385A (ru) 2013-07-27
NZ596823A (en) 2013-11-29
CN102802666A (zh) 2012-11-28
US20110123559A1 (en) 2011-05-26
KR20120101318A (ko) 2012-09-13
US8715691B2 (en) 2014-05-06
EP2448598A4 (en) 2013-10-23
CN102802666B (zh) 2015-06-03
US8088393B2 (en) 2012-01-03
NZ617191A (en) 2015-06-26
US20120244600A1 (en) 2012-09-27
EP2448598A1 (en) 2012-05-09
WO2010151673A1 (en) 2010-12-29
SG10201403557QA (en) 2014-10-30
EP2448598B1 (en) 2016-03-30
SG176178A1 (en) 2011-12-29
JP2012531205A (ja) 2012-12-10
MX2012000123A (es) 2012-03-07
CA2766377A1 (en) 2010-12-29
AU2014203458A1 (en) 2014-07-17
BRPI1014844A2 (pt) 2019-09-24

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired