JP2017510542A5 - - Google Patents
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- JP2017510542A5 JP2017510542A5 JP2016533700A JP2016533700A JP2017510542A5 JP 2017510542 A5 JP2017510542 A5 JP 2017510542A5 JP 2016533700 A JP2016533700 A JP 2016533700A JP 2016533700 A JP2016533700 A JP 2016533700A JP 2017510542 A5 JP2017510542 A5 JP 2017510542A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- gene editing
- gene
- editing protein
- synthetic rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461934397P | 2014-01-31 | 2014-01-31 | |
| US61/934,397 | 2014-01-31 | ||
| US201462038608P | 2014-08-18 | 2014-08-18 | |
| US62/038,608 | 2014-08-18 | ||
| US201462069667P | 2014-10-28 | 2014-10-28 | |
| US62/069,667 | 2014-10-28 | ||
| PCT/US2015/013949 WO2015117021A1 (en) | 2014-01-31 | 2015-01-30 | Methods and products for nucleic acid production and delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020128881A Division JP7235702B2 (ja) | 2014-01-31 | 2020-07-30 | 核酸生成及び送達のための方法及び製品 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017510542A JP2017510542A (ja) | 2017-04-13 |
| JP2017510542A5 true JP2017510542A5 (enExample) | 2018-03-08 |
Family
ID=53757787
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533700A Pending JP2017510542A (ja) | 2014-01-31 | 2015-01-30 | 核酸生成及び送達のための方法及び製品 |
| JP2020128881A Active JP7235702B2 (ja) | 2014-01-31 | 2020-07-30 | 核酸生成及び送達のための方法及び製品 |
| JP2023026873A Pending JP2023075165A (ja) | 2014-01-31 | 2023-02-24 | 核酸生成及び送達のための方法及び製品 |
| JP2024151104A Pending JP2025003953A (ja) | 2014-01-31 | 2024-09-03 | 核酸生成及び送達のための方法及び製品 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020128881A Active JP7235702B2 (ja) | 2014-01-31 | 2020-07-30 | 核酸生成及び送達のための方法及び製品 |
| JP2023026873A Pending JP2023075165A (ja) | 2014-01-31 | 2023-02-24 | 核酸生成及び送達のための方法及び製品 |
| JP2024151104A Pending JP2025003953A (ja) | 2014-01-31 | 2024-09-03 | 核酸生成及び送達のための方法及び製品 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9770489B2 (enExample) |
| EP (3) | EP3690056B1 (enExample) |
| JP (4) | JP2017510542A (enExample) |
| KR (3) | KR102726294B1 (enExample) |
| CN (1) | CN105940110A (enExample) |
| AU (3) | AU2015210769B2 (enExample) |
| BR (1) | BR112016017736A2 (enExample) |
| CA (1) | CA2937036A1 (enExample) |
| DK (1) | DK3690056T5 (enExample) |
| ES (2) | ES2939542T3 (enExample) |
| FI (1) | FI3690056T3 (enExample) |
| MX (2) | MX372651B (enExample) |
| RU (2) | RU2714404C2 (enExample) |
| WO (1) | WO2015117021A1 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| JP2017510542A (ja) | 2014-01-31 | 2017-04-13 | ファクター バイオサイエンス インコーポレイテッド | 核酸生成及び送達のための方法及び製品 |
| CA2956224A1 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| JP6728156B2 (ja) | 2014-11-02 | 2020-07-22 | アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | メッセンジャーｕｎａ分子およびその使用 |
| EP3543339A1 (en) * | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| EP4434589A3 (en) | 2015-10-23 | 2025-05-14 | President and Fellows of Harvard College | Evolved cas9 proteins for gene editing |
| EP3384038B1 (en) * | 2015-11-23 | 2024-07-24 | The Regents of The University of Colorado, A Body Corporate | Methods and compositions for reprogramming cells |
| PT3377637T (pt) * | 2016-04-08 | 2020-06-17 | Krystal Biotech Inc | Composições para uso em métodos para o tratamento de ferimentos, transtornos e doenças da pele |
| EP3241905A1 (en) * | 2016-05-06 | 2017-11-08 | Miltenyi Biotec GmbH | Method for introducing nucleic acids into a cell |
| WO2017197141A2 (en) * | 2016-05-13 | 2017-11-16 | Sangamo Therapeutics, Inc. | Targeted treatment of androgenic alopecia |
| WO2018003952A1 (ja) * | 2016-06-29 | 2018-01-04 | センジュ ユーエスエー、インコーポレイテッド | 経皮薬物送達システムおよびその使用方法 |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| CA3033788A1 (en) * | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| JP6953537B2 (ja) * | 2016-10-14 | 2021-10-27 | ネオマトリクス・セラピューティクス・インコーポレイテッド | 生物活性が改善され好中球エラスターゼ分解に対する感受性が低下した、フィブロネクチンに由来するペプチド |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| JP2020501545A (ja) * | 2016-12-08 | 2020-01-23 | キュアバック アーゲー | 肝疾患の処置または予防のためのｒｎａ |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| CA3057768A1 (en) | 2017-03-31 | 2018-10-04 | Accanis Biotech F&E Gmbh & Co Kg | Prevention and treatment of non-melanoma skin cancer (nmsc) |
| CN107400635A (zh) * | 2017-04-27 | 2017-11-28 | 广州弘宝元生物科技有限公司 | 导入α‑MSH多肽的粘红酵母重组菌株及其制备方法和应用 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| MX2019015188A (es) | 2017-06-15 | 2020-08-03 | Univ California | Inserciones de adn no virales orientadas. |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3437650A1 (en) | 2017-07-31 | 2019-02-06 | Accanis Biotech F&E GmbH & Co KG | Treatment of local skin hypotrophy conditions |
| BR102017016440A2 (pt) | 2017-07-31 | 2019-03-19 | Universidade Federal Do Rio Grande Do Sul | Composição para terapia gênica do sistema nervoso central, processo de obtenção e uso da mesma |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| US12208124B2 (en) | 2017-09-05 | 2025-01-28 | Azitra Inc. | Methods and compositions for treating inflammatory skin disease with recombinant microorganisms |
| AU2018347514C1 (en) * | 2017-10-11 | 2025-01-02 | Illustris Pharmaceuticals, Inc. | Methods and compositions for topical delivery |
| KR20200121782A (ko) | 2017-10-16 | 2020-10-26 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| JP7101419B2 (ja) | 2017-10-27 | 2022-07-15 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 内因性ｔ細胞受容体の標的置換 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3543351B1 (en) | 2018-03-19 | 2022-08-10 | Ricoh Company, Ltd. | Nucleic acid sample-contained container, method for producing nucleic acid sample-contained container, and nucleic acid sample |
| EP3775202A4 (en) * | 2018-03-27 | 2022-04-06 | Factor Bioscience Inc. | NUCLEIC ACID BASED THERAPEUTICS |
| CN112236153B (zh) | 2018-04-05 | 2025-04-29 | 阿兹特拉公司 | 用重组微生物治疗皮肤疾病的方法和组合物 |
| WO2019200163A1 (en) | 2018-04-12 | 2019-10-17 | Krystal Biotech, Inc. | Compositions and methods for the treatment of autosomal recessive congenital ichthyosis |
| AU2019260757B2 (en) * | 2018-04-27 | 2023-09-28 | Krystal Biotech, Inc. | Recombinant nucleic acids encoding cosmetic protein(s) for aesthetic applications |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| KR102712986B1 (ko) | 2018-08-23 | 2024-10-07 | 상가모 테라퓨틱스, 인코포레이티드 | 조작된 표적 특이적 염기 편집기 |
| AU2019346549B2 (en) | 2018-09-24 | 2024-09-12 | Krystal Biotech, Inc. | Compositions and methods for the treatment of Netherton Syndrome |
| AU2019346461B2 (en) * | 2018-09-26 | 2026-01-22 | Krystal Biotech, Inc. | Compositions and methods for the treatment of skin diseases |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020091137A1 (en) * | 2018-10-31 | 2020-05-07 | National Cancer Center | Composition comprising material for regulating oct4 modification to repress stemness |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| BR112021014400A2 (pt) | 2019-02-08 | 2021-09-21 | Krystal Biotech, Inc. | Genoma do vírus do herpes recombinante, vírus do herpes, composição farmacêutica, e, métodos para intensificar, aumentar, elevar e/ou suplementar os níveis de um polipeptídeo cftr em uma ou mais células, para reduzir ou inibir a destruição progressiva do pulmão, para fornecer alívio profilático, paliativo ou terapêutico de um ou mais sinais ou sintomas de fibrose cística e para fornecer alívio profilático, paliativo ou terapêutico de um ou mais sinais ou sintomas de copd |
| MA55083A (fr) * | 2019-03-01 | 2022-03-16 | Flagship Pioneering Innovations Vi Llc | Polyribonucléotides et leurs utilisations cosmétiques |
| MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US20210000910A1 (en) | 2019-07-03 | 2021-01-07 | Jysk Skin Solutions Pte Ltd | Topical compositions |
| US12344572B2 (en) | 2019-07-03 | 2025-07-01 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN110467667B (zh) * | 2019-09-03 | 2020-11-24 | 中国科学院理化技术研究所 | 一种抗肿瘤活性肽及其应用 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021226558A1 (en) | 2020-05-08 | 2021-11-11 | The Broad Institute, Inc. | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN114717229B (zh) * | 2021-01-05 | 2024-09-10 | 麦塞拿治疗(香港)有限公司 | 治疗性mRNA的无细胞和无载体体外RNA转录方法和核酸分子 |
| CA3213789A1 (en) | 2021-04-02 | 2022-10-06 | Krystal Biotech, Inc. | Viral vectors for cancer therapy |
| CN113603739B (zh) * | 2021-08-27 | 2024-08-23 | 上海兆维科技发展有限公司 | 一种加帽类似物及其应用 |
| CA3231676A1 (en) * | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| KR20240099259A (ko) | 2021-10-14 | 2024-06-28 | 아스널 바이오사이언시스, 인크. | 공동 발현된 shrna 및 논리 게이트 시스템을 갖는 면역 세포 |
| CN114150022B (zh) * | 2021-12-06 | 2023-08-22 | 中国科学院精密测量科学与技术创新研究院 | 一种基于植物微纳结构的生化分子细胞递送方法及应用 |
| JP7271026B1 (ja) | 2021-12-28 | 2023-05-11 | 株式会社Hyperion Drug Discovery | 遺伝子導入細胞の免疫応答を回避させるための剤 |
| AU2023205751A1 (en) * | 2022-01-05 | 2024-07-11 | Helix Nanotechnologies Inc | Compositions comprising alpha-factor prepro sequence and uses thereof |
| CN114480365B (zh) * | 2022-01-18 | 2024-05-28 | 南昌大学 | 一种高分子-酶-无机杂化纳米花及其制备方法与其在降解食用油中真菌毒素的应用 |
| WO2023191016A1 (ja) * | 2022-03-30 | 2023-10-05 | ヤマサ醤油株式会社 | フィブリリン産生促進剤、化粧料組成物又は皮膚外用剤、経口投与剤、及びエラスチン線維産生促進剤 |
| US12083204B2 (en) | 2022-06-02 | 2024-09-10 | L'oreal | Topical composition for homeostatic delivery of nitric oxide and uses thereof |
| EP4570785A1 (en) | 2022-08-10 | 2025-06-18 | Hanwha Solutions Corporation | Preparation method of isocyanate composition and isocyanate composition |
| WO2024158256A1 (ko) * | 2023-01-27 | 2024-08-02 | 주식회사 차메디텍 | 니도겐을 포함하는 피부 상태 개선, 피부 손상 치료 또는 줄기세포능 유지용 조성물 |
| CN116474120A (zh) * | 2023-04-03 | 2023-07-25 | 臻赫医药(杭州)有限公司 | 重编程因子抗衰老mRNA组合物、制备方法及应用 |
| EP4694903A1 (en) * | 2023-04-11 | 2026-02-18 | Eliksa Therapeutics, Inc. | Methods of increasing therapeutic protein levels and/or improving cellular function with amniotic fluid compositions |
| WO2025024500A1 (en) * | 2023-07-25 | 2025-01-30 | Passport Technologies, Inc. | Methods and systems for transdermal immunotherapy |
| CN117683116B (zh) * | 2023-10-17 | 2025-08-15 | 百世美生物技术(浙江)有限公司 | 一种重组人源弹性蛋白及其制备方法与应用 |
| CN117904149A (zh) * | 2023-10-25 | 2024-04-19 | 中国医学科学院北京协和医院 | 一种表达酪氨酸酶的mRNA及用途 |
Family Cites Families (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3539465A (en) | 1968-10-08 | 1970-11-10 | Ncr Co | Encapsulation of hydrophilic liquid-in-oil emulsions |
| US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5711964A (en) | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| US6602693B1 (en) | 1996-07-03 | 2003-08-05 | Clear Solutions Biotech, Inc. | Gene encoding hyaluronan synthase |
| US6413544B1 (en) | 1996-08-19 | 2002-07-02 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
| US6770291B2 (en) | 1996-08-30 | 2004-08-03 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
| TW520297B (en) | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| AU5734998A (en) | 1997-01-10 | 1998-08-03 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US6316260B1 (en) | 1997-08-22 | 2001-11-13 | Bernina Biosystems Gmbh | Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraether lipid derivatives, and use thereof |
| AU9319398A (en) | 1997-09-19 | 1999-04-05 | Sequitur, Inc. | Sense mrna therapy |
| DE60044084D1 (de) | 1999-06-04 | 2010-05-12 | Georgia Tech Res Inst | Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten |
| US20110171185A1 (en) | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
| US20020054895A1 (en) | 1999-07-23 | 2002-05-09 | Alwyn Company, Inc. | Allantoin-containing skin cream |
| US20020064876A1 (en) * | 1999-12-28 | 2002-05-30 | Kyonggeun Yoon | Novel gene therapy methods for the treatment of skin disorders |
| US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
| JP2004509970A (ja) | 2000-09-26 | 2004-04-02 | ハイブリドン・インコーポレイテッド | 位置的化学変化による免疫刺激オリゴヌクレオチドアナログの免疫刺激活性の調節 |
| US7189759B2 (en) * | 2001-05-23 | 2007-03-13 | Medicis Pharmaceutical Corporation | Compositions for the treatment of pigmentation disorders and methods for their manufacture |
| AU2002313817A1 (en) | 2001-08-27 | 2003-03-10 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| EP1437403A4 (en) | 2001-09-21 | 2004-10-27 | Japan Science & Tech Corp | METHOD FOR PATTERNING REPROGRAMMING FACTOR, METHOD OF PATTERNED REPROGRAMMING FACTOR, METHOD FOR USE OF REPROGRAMMING FACTOR, METHOD FOR DIFFERENTIATING AND SIFE-INGENATING FAN |
| WO2003033697A1 (en) | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| GB0202149D0 (en) | 2002-01-30 | 2002-03-20 | Univ Edinburgh | Pluripotency determining factors and uses thereof |
| US20030186249A1 (en) | 2002-04-01 | 2003-10-02 | Zairen Sun | Human TARPP genes and polypeptides |
| JP3785508B2 (ja) | 2002-04-15 | 2006-06-14 | 学校法人慶應義塾 | 遺伝子治療における免疫応答を解析できる実験モデルマウス |
| US7737182B2 (en) * | 2002-08-09 | 2010-06-15 | Taisho Pharmaceutical Co., Ltd. | Pharmaceuticals for xerosis |
| BRPI0410886A (pt) | 2003-06-03 | 2006-07-04 | Isis Pharmaceuticals Inc | composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único |
| JP2005046073A (ja) * | 2003-07-29 | 2005-02-24 | National Institute Of Advanced Industrial & Technology | 修飾核酸を用いるｒｎａ転写および／または増幅方法 |
| JP2007512355A (ja) | 2003-11-21 | 2007-05-17 | アルザ コーポレイション | 開裂性のｐｅｇで表面修飾されたリポソーム−ｄｎａ複合体で媒介される遺伝子送達 |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| NZ553235A (en) | 2004-09-08 | 2009-11-27 | Wisconsin Alumni Res Found | Culturing human pluripotent stem cells |
| CN101052712A (zh) | 2004-09-08 | 2007-10-10 | 威斯康星校友研究基金会 | 培养人胚胎干细胞 |
| EP1913149A4 (en) | 2005-07-26 | 2009-08-05 | Sangamo Biosciences Inc | TARGETED INTEGRATION AND EXPRESSION OF EXOGENOUS NUCLEIC ACID SEQUENCES |
| US8323666B2 (en) | 2005-08-01 | 2012-12-04 | Allergan, Inc. | Botulinum toxin compositions |
| US9012219B2 (en) | 2005-08-23 | 2015-04-21 | The Trustees Of The University Of Pennsylvania | RNA preparations comprising purified modified RNA for reprogramming cells |
| RS63964B1 (sr) | 2005-08-23 | 2023-03-31 | Univ Pennsylvania | Rnk koja sadrži modifikovane nukleozide i postupci za njenu upotrebu |
| WO2007026353A2 (en) | 2005-08-29 | 2007-03-08 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| CN101356270B (zh) | 2005-12-13 | 2014-02-12 | 国立大学法人京都大学 | 核重新编程因子 |
| JP2009520714A (ja) | 2005-12-22 | 2009-05-28 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 低オクタノエート型ヒトアルブミン |
| DE102006051516A1 (de) | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins |
| GB0623635D0 (en) | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
| AU2007333225B2 (en) | 2006-12-08 | 2014-06-12 | Massachusetts Institute Of Technology | Delivery of nanoparticles and/or agents to cells |
| CN101200758A (zh) | 2006-12-15 | 2008-06-18 | 华中科技大学 | 一种检测col7a1基因突变的方法及其用途 |
| US10829733B2 (en) | 2007-01-04 | 2020-11-10 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent human stem cells |
| US8859229B2 (en) | 2007-02-02 | 2014-10-14 | Yale University | Transient transfection with RNA |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| AU2008231020B2 (en) | 2007-03-23 | 2013-09-05 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| EP2626416A3 (en) | 2007-04-07 | 2013-12-18 | The Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| WO2009046739A1 (en) * | 2007-10-09 | 2009-04-16 | Curevac Gmbh | Composition for treating prostate cancer (pca) |
| AU2008286249B2 (en) | 2007-12-10 | 2013-10-10 | Kyoto University | Efficient method for nuclear reprogramming |
| EP2072618A1 (en) | 2007-12-14 | 2009-06-24 | Johannes Gutenberg-Universität Mainz | Use of RNA for reprogramming somatic cells |
| WO2009117439A2 (en) | 2008-03-17 | 2009-09-24 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| US20110045001A1 (en) | 2008-03-28 | 2011-02-24 | Biontex Laboratories Gmbh | Transfection results of non-viral gene delivery systems by influencing of the innate immune system |
| WO2009127230A1 (en) | 2008-04-16 | 2009-10-22 | Curevac Gmbh | MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION |
| JP2011522540A (ja) | 2008-06-04 | 2011-08-04 | セルラー ダイナミクス インターナショナル， インコーポレイテッド | 非ウイルスアプローチを用いたｉＰＳ細胞の産生のための方法 |
| WO2009147400A1 (en) | 2008-06-05 | 2009-12-10 | Iti Scotland Limited | Stem cell culture media and methods |
| US8669048B2 (en) | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
| US20100184033A1 (en) | 2008-07-16 | 2010-07-22 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| EP2151248A1 (en) | 2008-07-30 | 2010-02-10 | Johann Bauer | Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses |
| US20110263015A1 (en) | 2008-08-20 | 2011-10-27 | Virxsys Corporation | Compositions and methods for generation of pluripotent stem cells |
| DK2356221T3 (en) | 2008-10-24 | 2019-02-18 | Wisconsin Alumni Res Found | Pluripotent stem cells obtained by non-viral reprogramming |
| ES2561949T3 (es) | 2008-11-21 | 2016-03-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Reprogramación de células hacia un estado pluripotente |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
| WO2010093655A2 (en) | 2009-02-10 | 2010-08-19 | University Of Dayton | Enhanced method for producing stem-like cells from somatic cells |
| US10894944B2 (en) | 2009-04-10 | 2021-01-19 | Monash University | Cell culture media |
| US10837020B2 (en) | 2009-04-22 | 2020-11-17 | Massachusetts Institute Of Technology | Innate immune suppression enables repeated delivery of long RNA molecules |
| JP2012524777A (ja) * | 2009-04-22 | 2012-10-18 | マサチューセッツ インスティテュート オブ テクノロジー | 長いｒｎａ分子の反復送達を可能にする自然免疫抑制 |
| EP2421563B1 (en) | 2009-04-22 | 2017-04-12 | Massachusetts Institute of Technology | Innate immune suppression enables repeated delivery of long rna molecules |
| ES2849181T3 (es) | 2009-04-22 | 2021-08-16 | Viacyte Inc | Composiciones celulares derivadas de células reprogramadas desdiferenciadas |
| EP2251437B1 (en) | 2009-05-13 | 2013-12-04 | Hannelore Breitenbach-Koller | Method for identifying compounds that control the translational activity of ribosomal proteins in differential mRNA expression |
| US8496941B2 (en) | 2009-06-03 | 2013-07-30 | National Institute Of Advanced Industrial Science And Technology | Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same |
| JP5944311B2 (ja) * | 2009-06-16 | 2016-07-05 | クルナ・インコーポレーテッド | コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療 |
| BR112012002291A2 (pt) | 2009-07-31 | 2016-11-29 | Ethris Gmbh | "polirribonucleotídeo com uma sequência que codifica uma proteína ou fragmento de proteína, implante, e, processo para a seleção de sequências de nucleotídeos" |
| US9295697B2 (en) | 2009-11-04 | 2016-03-29 | Cellular Dynamics International, Inc. | Episomal reprogramming with chemicals |
| KR20120107088A (ko) | 2009-11-11 | 2012-09-28 | 샌포드-번햄 메디칼 리서치 인스티튜트 | ⅰＰＳ 세포들의 생산 및 조절 방법 및 그들의 조성물들 |
| US20130189741A1 (en) | 2009-12-07 | 2013-07-25 | Cellscript, Inc. | Compositions and methods for reprogramming mammalian cells |
| SI3112467T1 (en) | 2009-12-07 | 2018-06-29 | The Trustees Of The University Of Pennsylvania | Rna preparations comprising purified modified rna for reprogramming cells |
| EP3456826B1 (en) | 2009-12-10 | 2023-06-28 | Regents of the University of Minnesota | Tal effector-mediated dna modification |
| US8557972B2 (en) | 2009-12-21 | 2013-10-15 | University Of Washington Through Its Center For Commercialization | Compositions and methods for transfection of RNA and controlled stabilization of transfected RNA |
| WO2011094738A1 (en) | 2010-02-01 | 2011-08-04 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced efficiency of induced pluripotent stem cell generation |
| US20140194482A1 (en) | 2010-02-02 | 2014-07-10 | Scioderm, Inc. | Compositions and methods of treatment of inflammatory skin conditions using allantoin |
| WO2011110886A1 (en) | 2010-03-09 | 2011-09-15 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent human stem cells |
| EP2558571A4 (en) | 2010-04-16 | 2014-09-24 | Immune Disease Inst Inc | DELAYED POLYPEPTIDE EXPRESSION FROM MODIFIED SYNTHETIC RNAS AND USES THEREOF |
| US9725695B2 (en) | 2010-05-05 | 2017-08-08 | The Regents Of The University Of California | Stem cell defined media for xeno-free and feeder free conditions and uses thereof |
| WO2011141820A1 (en) | 2010-05-12 | 2011-11-17 | Cellectis | Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof |
| US8048675B1 (en) | 2010-05-12 | 2011-11-01 | Ipierian, Inc. | Integration-free human induced pluripotent stem cells from blood |
| JP6208580B2 (ja) | 2010-05-17 | 2017-10-04 | サンガモ セラピューティクス， インコーポレイテッド | 新規のｄｎａ結合タンパク質及びその使用 |
| EP2392208B1 (en) | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use |
| BR112013002811A8 (pt) | 2010-08-05 | 2020-01-28 | Wisconsin Alumni Res Found | meios básicos simplificados para cultura celular pluripotente de humano |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2616540A4 (en) | 2010-09-14 | 2014-02-19 | Univ Kyoto | METHOD FOR EFFICIENT MANUFACTURE OF INDUCED PLURIPOTENTER STEM CELLS |
| DK4108671T3 (da) | 2010-10-01 | 2025-01-06 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf |
| EP2625278A1 (en) | 2010-10-08 | 2013-08-14 | Regents of the University of Minnesota | A method to increase gene targeting frequency |
| JP5888753B2 (ja) | 2010-11-04 | 2016-03-22 | 国立大学法人京都大学 | 効率的な人工多能性幹細胞の樹立方法 |
| CN103502436A (zh) | 2011-03-07 | 2014-01-08 | 麻省理工学院 | 用核酸转染细胞的方法 |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| WO2012131090A1 (en) * | 2011-03-31 | 2012-10-04 | Galderma Research & Development | Method for treatment of xeroderma pigmentosum |
| US10086043B2 (en) | 2011-04-03 | 2018-10-02 | The General Hospital Corporation | Efficient protein expression in vivo using modified RNA (MOD-RNA) |
| WO2012174224A2 (en) * | 2011-06-17 | 2012-12-20 | Calando Pharmaceuticals, Inc. | Methods for administering nucleic acid-based therapeutics |
| WO2012176015A1 (en) * | 2011-06-24 | 2012-12-27 | Leo Pharma A/S | Methods for treating uv-damaged skin and scc tumors and for removing tattoos with topical ingenol mebutate |
| US9862926B2 (en) | 2011-06-27 | 2018-01-09 | Cellscript, Llc. | Inhibition of innate immune response |
| EP2732029B1 (en) * | 2011-07-11 | 2019-01-16 | FUJIFILM Cellular Dynamics, Inc. | Methods for cell reprogramming and genome engineering |
| CN108165593A (zh) | 2011-08-03 | 2018-06-15 | 凤凰组织修复公司 | 胶原蛋白7及相关方法 |
| JP6113737B2 (ja) | 2011-10-03 | 2017-04-12 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | 修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法 |
| EP3279324B1 (en) * | 2011-10-11 | 2021-02-17 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Exon skipping therapy for dystrophic epidermolysis bullosa |
| JP2013086009A (ja) | 2011-10-17 | 2013-05-13 | Yamamoto Co Ltd | 自動精米装置 |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| RU2624139C2 (ru) * | 2011-12-05 | 2017-06-30 | Фэктор Байосайенс Инк. | Способы и препараты для трансфекции клеток |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| CA2859691A1 (en) | 2011-12-21 | 2013-06-27 | Moderna Therapeutics, Inc. | Methods of increasing the viability or longevity of an organ or organ explant |
| EP3421601B1 (en) | 2011-12-30 | 2019-12-04 | Cellscript, Llc | Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| AU2013251649B2 (en) | 2012-04-24 | 2019-04-04 | Vcell Therapeutics, Inc. | Generating pluripotent cells de novo |
| WO2013173248A2 (en) | 2012-05-13 | 2013-11-21 | Allele Biotechnology And Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna |
| US10119150B2 (en) | 2012-05-13 | 2018-11-06 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
| US10155929B2 (en) | 2012-05-13 | 2018-12-18 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
| WO2014015314A1 (en) | 2012-07-19 | 2014-01-23 | University Of Southern California | Recombinant c7 and methods of use |
| KR101979746B1 (ko) * | 2012-09-13 | 2019-05-17 | (주)아모레퍼시픽 | 전기 천공 장치 |
| WO2014093622A2 (en) * | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| RU2022101438A (ru) | 2013-02-22 | 2022-02-11 | Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити | Соединения, композиции, способы и наборы, связанные с удлинением теломер |
| ES2750550T3 (es) * | 2013-03-01 | 2020-03-26 | Univ Minnesota | Corrección de gen a base de TALEN |
| WO2015038075A1 (en) * | 2013-09-16 | 2015-03-19 | Agency For Science, Technology And Research | Method |
| JP2017510542A (ja) | 2014-01-31 | 2017-04-13 | ファクター バイオサイエンス インコーポレイテッド | 核酸生成及び送達のための方法及び製品 |
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