JP2016512691A5 - - Google Patents

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JP2016512691A5
JP2016512691A5 JP2016502976A JP2016502976A JP2016512691A5 JP 2016512691 A5 JP2016512691 A5 JP 2016512691A5 JP 2016502976 A JP2016502976 A JP 2016502976A JP 2016502976 A JP2016502976 A JP 2016502976A JP 2016512691 A5 JP2016512691 A5 JP 2016512691A5
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complementary
nucleotides
sequence
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JP2016502976A 2013-03-15 2014-03-14 短縮ガイドRNA(tru−gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大 Active JP6980380B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201361799647P 2013-03-15 2013-03-15
US61/799,647 2013-03-15
US201361838178P 2013-06-21 2013-06-21
US201361838148P 2013-06-21 2013-06-21
US61/838,148 2013-06-21
US61/838,178 2013-06-21
US201361921007P 2013-12-26 2013-12-26
US61/921,007 2013-12-26
PCT/US2014/029068 WO2014144592A2 (en) 2013-03-15 2014-03-14 Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing

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JP2020055863A Division JP7053706B2 (ja) 2013-03-15 2020-03-26 短縮ガイドRNA(tru-gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大

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JP2016512691A JP2016512691A (ja) 2016-05-09
JP2016512691A5 true JP2016512691A5 (enExample) 2017-04-20
JP6980380B2 JP6980380B2 (ja) 2021-12-15

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JP2016502853A Active JP6622183B2 (ja) 2013-03-15 2014-03-14 RNA誘導型FokIヌクレアーゼ(RFN)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2016502406A Active JP6657069B2 (ja) 2013-03-15 2014-03-14 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化
JP2016502976A Active JP6980380B2 (ja) 2013-03-15 2014-03-14 短縮ガイドRNA(tru−gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2019176599A Active JP6960438B2 (ja) 2013-03-15 2019-09-27 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化
JP2019210428A Active JP6878554B2 (ja) 2013-03-15 2019-11-21 RNA誘導型FokIヌクレアーゼ(RFN)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2020055863A Active JP7053706B2 (ja) 2013-03-15 2020-03-26 短縮ガイドRNA(tru-gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2021075869A Active JP7126588B2 (ja) 2013-03-15 2021-04-28 RNA誘導型FokIヌクレアーゼ(RFN)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2021138479A Pending JP2021192624A (ja) 2013-03-15 2021-08-27 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化
JP2022056499A Active JP7379572B2 (ja) 2013-03-15 2022-03-30 短縮ガイドRNA(tru-gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2023011473A Withdrawn JP2023061983A (ja) 2013-03-15 2023-01-30 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化
JP2023186663A Pending JP2024012446A (ja) 2013-03-15 2023-10-31 短縮ガイドRNA(tru-gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大

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JP2016502853A Active JP6622183B2 (ja) 2013-03-15 2014-03-14 RNA誘導型FokIヌクレアーゼ(RFN)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2016502406A Active JP6657069B2 (ja) 2013-03-15 2014-03-14 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化

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JP2019176599A Active JP6960438B2 (ja) 2013-03-15 2019-09-27 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化
JP2019210428A Active JP6878554B2 (ja) 2013-03-15 2019-11-21 RNA誘導型FokIヌクレアーゼ(RFN)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2020055863A Active JP7053706B2 (ja) 2013-03-15 2020-03-26 短縮ガイドRNA(tru-gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2021075869A Active JP7126588B2 (ja) 2013-03-15 2021-04-28 RNA誘導型FokIヌクレアーゼ(RFN)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2021138479A Pending JP2021192624A (ja) 2013-03-15 2021-08-27 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化
JP2022056499A Active JP7379572B2 (ja) 2013-03-15 2022-03-30 短縮ガイドRNA(tru-gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大
JP2023011473A Withdrawn JP2023061983A (ja) 2013-03-15 2023-01-30 特定のゲノム遺伝子座へのゲノムおよびエピゲノム調節タンパク質のrna誘導型標的化
JP2023186663A Pending JP2024012446A (ja) 2013-03-15 2023-10-31 短縮ガイドRNA(tru-gRNA)を用いたRNA誘導型ゲノム編集の特異性の増大

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US (17) US9885033B2 (enExample)
EP (10) EP3467125B1 (enExample)
JP (11) JP6622183B2 (enExample)
KR (8) KR102271291B1 (enExample)
CN (6) CN105247066B (enExample)
AU (10) AU2014228981B2 (enExample)
BR (1) BR112015023489B1 (enExample)
CA (4) CA3161835A1 (enExample)
ES (1) ES2713503T3 (enExample)
IL (2) IL289396B2 (enExample)
WO (4) WO2014144288A1 (enExample)
ZA (1) ZA201506814B (enExample)

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EP3579858A4 (en) 2017-02-07 2020-12-23 The Regents of The University of California GENE THERAPY AGAINST HAPLOINSUFFICIENCY
CA3059208A1 (en) 2017-04-21 2018-10-25 The General Hospital Corporation Inducible, tunable, and multiplex human gene regulation using crispr-cpf1
US11041155B2 (en) 2018-05-17 2021-06-22 The General Hospital Corporation CCCTC-binding factor variants
JP2023503618A (ja) 2019-11-27 2023-01-31 ザ ジェネラル ホスピタル コーポレイション 遺伝子発現を活性化するためのシステムおよび方法
EP4176434A4 (en) 2020-05-29 2024-09-11 The General Hospital Corporation Systems and methods for stable and heritable alteration by precision editing (shape)

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