BR112016017736A2 - métodos e produtos para produção e distribuição de ácido nucleico - Google Patents

métodos e produtos para produção e distribuição de ácido nucleico

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Publication number
BR112016017736A2
BR112016017736A2 BR112016017736A BR112016017736A BR112016017736A2 BR 112016017736 A2 BR112016017736 A2 BR 112016017736A2 BR 112016017736 A BR112016017736 A BR 112016017736A BR 112016017736 A BR112016017736 A BR 112016017736A BR 112016017736 A2 BR112016017736 A2 BR 112016017736A2
Authority
BR
Brazil
Prior art keywords
methods
nucleic acids
cells
products
therapeutic
Prior art date
Application number
BR112016017736A
Other languages
English (en)
Inventor
Rohde Christopher
Angel Matthew
Original Assignee
Factor Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Factor Bioscience Inc filed Critical Factor Bioscience Inc
Publication of BR112016017736A2 publication Critical patent/BR112016017736A2/pt

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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/83—Electrophoresis; Electrodes; Electrolytic phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Abstract

a presente invenção refere-se, em parte, aos ácidos nucleicos, incluindo ácidos nucleicos que codificam proteínas, agentes terapêuticos e cosméticos que compreendem ácidos nucleicos, métodos para distribuição de ácidos nucleicos para células, tecidos, órgãos e pacientes, métodos para induzir as células para que expressem proteínas utilizando ácidos nucleicos, métodos, kits e dispositivos para transfecção, edição gênica e reprogramação de células, e células, organismos, agentes terapêuticos e cosméticos produzidos utilizando estes métodos, kits e dispositivos. são descritos métodos e produtos para alterar a sequência de dna de uma célula, assim como os métodos e produtos para induzir as células a expressarem proteínas usando moléculas de rna sintéticos, incluindo células presentes in vivo. também são descritos produtos terapêuticos compreendendo ácidos nucleicos que codificam proteínas de edição gênica.
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