JP2021523739A5 - - Google Patents
Info
- Publication number
- JP2021523739A5 JP2021523739A5 JP2021513765A JP2021513765A JP2021523739A5 JP 2021523739 A5 JP2021523739 A5 JP 2021523739A5 JP 2021513765 A JP2021513765 A JP 2021513765A JP 2021513765 A JP2021513765 A JP 2021513765A JP 2021523739 A5 JP2021523739 A5 JP 2021523739A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- rtt
- mecp2
- base editor
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024095566A JP2024138268A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862670588P | 2018-05-11 | 2018-05-11 | |
| US62/670,588 | 2018-05-11 | ||
| US201862780838P | 2018-12-17 | 2018-12-17 | |
| US62/780,838 | 2018-12-17 | ||
| US201962817986P | 2019-03-13 | 2019-03-13 | |
| US62/817,986 | 2019-03-13 | ||
| PCT/US2019/031899 WO2019217944A1 (en) | 2018-05-11 | 2019-05-11 | Methods of editing single nucleotide polymorphism using programmable base editor systems |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024095566A Division JP2024138268A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523739A JP2021523739A (ja) | 2021-09-09 |
| JP2021523739A5 true JP2021523739A5 (enExample) | 2022-05-19 |
| JP7596259B2 JP7596259B2 (ja) | 2024-12-09 |
Family
ID=68466849
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513764A Pending JP2021523738A (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
| JP2021513765A Active JP7596259B2 (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
| JP2024095618A Pending JP2024147545A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
| JP2024095566A Pending JP2024138268A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513764A Pending JP2021523738A (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024095618A Pending JP2024147545A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
| JP2024095566A Pending JP2024138268A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20210380955A1 (enExample) |
| EP (2) | EP3790595A4 (enExample) |
| JP (4) | JP2021523738A (enExample) |
| KR (4) | KR102853088B1 (enExample) |
| CN (3) | CN112469446B (enExample) |
| AU (3) | AU2019266326B2 (enExample) |
| CA (2) | CA3100034A1 (enExample) |
| WO (2) | WO2019217944A1 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016226077B2 (en) | 2015-03-03 | 2021-12-23 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases with altered PAM specificity |
| CN110612353A (zh) | 2017-03-03 | 2019-12-24 | 加利福尼亚大学董事会 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| US11371030B2 (en) | 2017-05-31 | 2022-06-28 | The University Of Tokyo | Modified Cas9 protein and use thereof |
| WO2019040650A1 (en) | 2017-08-23 | 2019-02-28 | The General Hospital Corporation | GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES HAVING MODIFIED PAM SPECIFICITY |
| US20200370040A1 (en) * | 2017-12-07 | 2020-11-26 | Ramot At Tel-Aviv University Ltd. | Treatment for parkinsonian patients with mutations in the lrrk2 gene |
| PL3765615T3 (pl) | 2018-03-14 | 2023-11-13 | Arbor Biotechnologies, Inc. | Nowe enzymy i układy crispr ukierunkowane na dna |
| WO2019217942A1 (en) | 2018-05-11 | 2019-11-14 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| WO2019222555A1 (en) | 2018-05-16 | 2019-11-21 | Arbor Biotechnologies, Inc. | Novel crispr-associated systems and components |
| WO2019226953A1 (en) * | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| KR20210055733A (ko) | 2018-09-07 | 2021-05-17 | 빔 테라퓨틱스, 인크. | 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN114096666B (zh) | 2019-02-13 | 2025-03-18 | 比姆医疗股份有限公司 | 治疗血红素病变的组合物和方法 |
| US20220127594A1 (en) * | 2019-02-13 | 2022-04-28 | Beam Therapeutics Inc. | Compositions and methods for treating glycogen storage disease type 1a |
| WO2020168135A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Compositions and methods for treating alpha-1 antitrypsin deficiency |
| US12600971B2 (en) | 2019-02-13 | 2026-04-14 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| CN111793627A (zh) * | 2019-04-08 | 2020-10-20 | 中国科学院上海生命科学研究院 | 利用人工构建rna编辑酶进行rna定点编辑及相关应用 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| JP7679311B2 (ja) * | 2019-05-21 | 2025-05-19 | ビーム セラピューティクス インク． | プログラム可能塩基エディターシステムを用いた一塩基多型編集法 |
| US20220259617A1 (en) | 2019-06-13 | 2022-08-18 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| JP7500927B2 (ja) * | 2019-08-06 | 2024-06-18 | 日本製紙株式会社 | プロテイン用マスキング剤 |
| US12594301B2 (en) | 2019-09-27 | 2026-04-07 | Beam Therapeutics Inc. | Compositions and methods for treatment of liquid cancers |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| JP7785002B2 (ja) | 2019-11-05 | 2025-12-12 | ペアーワイズ プランツ サービシズ， インコーポレイテッド | 対立遺伝子のｒｎａにコードされたｄｎａの置換のための組成物および方法 |
| US11827880B2 (en) | 2019-12-02 | 2023-11-28 | Shape Therapeutics Inc. | Therapeutic editing |
| WO2021122944A1 (en) * | 2019-12-18 | 2021-06-24 | Alia Therapeutics Srl | Compositions and methods for treating retinitis pigmentosa |
| EP4093864A4 (en) | 2020-01-24 | 2024-04-10 | The General Hospital Corporation | Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants |
| WO2021151085A2 (en) | 2020-01-24 | 2021-07-29 | The General Hospital Corporation | Crispr-cas enzymes with enhanced on-target activity |
| WO2021155166A1 (en) * | 2020-01-31 | 2021-08-05 | University Of Massachusetts | A cas9-pdbd base editor platform with improved targeting range and specificity |
| EP4103705A4 (en) * | 2020-02-14 | 2024-02-28 | Ohio State Innovation Foundation | Nucleobase editors and methods of use thereof |
| IT202000008014A1 (it) * | 2020-04-15 | 2021-10-15 | Fond Telethon | RNA guida e loro usi |
| WO2021216622A1 (en) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom |
| US20230165909A1 (en) * | 2020-04-21 | 2023-06-01 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
| WO2021222318A1 (en) | 2020-04-28 | 2021-11-04 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| WO2021231691A1 (en) * | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi) |
| US20230190893A1 (en) * | 2020-07-14 | 2023-06-22 | The Regents Of The University Of California | Compositions and methods for treating an inherited retinal disease |
| BR112023001272A2 (pt) | 2020-07-24 | 2023-04-04 | Massachusetts Gen Hospital | Partículas semelhantes a vírus aprimoradas e métodos de uso das mesmas para entrega às células |
| WO2022027035A1 (en) * | 2020-07-27 | 2022-02-03 | The Children's Hospital Of Philadelphia | In utero and postnatal gene editing and therapy for treatment of monogenic diseases, including mucopolysaccharidosis type 1h and other disorders |
| CA3193099A1 (en) * | 2020-09-24 | 2022-03-31 | David R. Liu | Prime editing guide rnas, compositions thereof, and methods of using the same |
| AU2021347359A1 (en) | 2020-09-25 | 2023-05-18 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| AU2021374974A1 (en) * | 2020-11-06 | 2023-05-25 | Pairwise Plants Services, Inc. | Compositions and methods for rna-encoded dna-replacement of alleles |
| CN116829176A (zh) * | 2020-12-10 | 2023-09-29 | 阿佩利斯制药有限公司 | 补体基因组编辑 |
| AU2022206308A1 (en) * | 2021-01-07 | 2023-08-10 | Massachusetts Institute Of Technology | Dna nuclease guided transposase compositions and methods of use thereof |
| WO2022197727A1 (en) * | 2021-03-15 | 2022-09-22 | Duke University | Generation of novel crispr genome editing agents using combinatorial chemistry |
| CN117729931A (zh) * | 2021-05-14 | 2024-03-19 | 比姆医疗股份有限公司 | 用于治疗转甲状腺素蛋白淀粉样变性的组合物和方法 |
| CA3220738A1 (en) * | 2021-05-21 | 2022-11-24 | Beam Therapeutics Inc. | Base editing of transthyretin gene |
| KR20240012377A (ko) * | 2021-05-28 | 2024-01-29 | 빔 테라퓨틱스, 인크. | 염기 편집기의 자기-불활성화용 조성물 및 방법 |
| KR20240099269A (ko) * | 2021-10-13 | 2024-06-28 | 아펠리스 파마슈티컬스 인코포레이티드 | 신생아 fc 수용체의 게놈 편집을 위한 조성물 및 방법 |
| US20250223584A2 (en) | 2021-12-03 | 2025-07-10 | The Broad Institute, Inc. | Compositions and methods for efficient in vivo delivery |
| WO2023140694A1 (ko) * | 2022-01-24 | 2023-07-27 | 주식회사 툴젠 | 스트렙토코커스 피오게네스 유래 cas9 변이체 |
| CN114480445B (zh) * | 2022-01-26 | 2023-06-27 | 西南交通大学 | 一种人源超氧化物歧化酶hSOD1突变体的制备及其应用 |
| EP4522738A1 (en) * | 2022-05-13 | 2025-03-19 | Huidagene Therapeutics (Singapore) Pte. Ltd. | Programmable adenine base editor and uses thereof |
| JP2025519070A (ja) | 2022-05-17 | 2025-06-24 | エンヴェロップ セラピューティクス， インコーポレイテッド | 効率的ｉｎ ｖｉｖｏ送達のための組成物および方法 |
| CN115148281B (zh) * | 2022-06-29 | 2023-07-14 | 广州源井生物科技有限公司 | 一种基因编辑点突变方案自动设计方法及系统 |
| CA3266991A1 (en) * | 2022-09-08 | 2024-03-14 | The University Court Of The University Of Edinburgh | TREATMENT OF RETT SYNDROME |
| WO2024107784A2 (en) * | 2022-11-15 | 2024-05-23 | Vanderbilt University | Repair of disease-associated single nucleotide variants via interallelic gene conversion |
| CN116286740A (zh) * | 2023-02-24 | 2023-06-23 | 四川大学华西医院 | 碱基编辑器和引导编辑器及构建与应用 |
| CN121889499A (zh) * | 2023-06-15 | 2026-04-17 | 比姆医疗股份有限公司 | 用于治疗α1-抗胰蛋白酶缺乏症的方法和组合物 |
| KR20260044217A (ko) * | 2023-07-25 | 2026-04-01 | 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 | Cas 엔도뉴클레아제 및 관련 방법 |
| US20250059567A1 (en) * | 2023-08-17 | 2025-02-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for the management and treatment of phenylketonuria |
| WO2025049283A2 (en) | 2023-08-25 | 2025-03-06 | Trustees Of Boston University | Engineered mcp and pcp proteins and systems and methods thereof |
| EP4777618A1 (en) * | 2023-09-15 | 2026-07-22 | Beam Therapeutics Inc. | Compositions and methods for base editing a phenylalanine hydroxylase polynucleotide |
| CN120813698A (zh) * | 2023-09-22 | 2025-10-17 | 北京大学现代农业研究院 | 改进的基因组编辑方法 |
| WO2025122725A1 (en) * | 2023-12-06 | 2025-06-12 | The Broad Institute, Inc. | Methods and compositions for base editing of tpp1 in the treatment of batten disease |
| CN118120704B (zh) * | 2024-01-30 | 2025-10-24 | 江苏集萃药康生物科技股份有限公司 | 一种免高脂饮食诱导的动脉粥样硬化小鼠模型的构建方法 |
| WO2026024892A2 (en) * | 2024-07-23 | 2026-01-29 | The General Hospital Corporation | Activity-enhanced engineered spcas9 pam variant enzymes for efficient and specific genome editing |
| WO2026055273A1 (en) * | 2024-09-03 | 2026-03-12 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods thereof |
| WO2026128564A1 (en) * | 2024-12-11 | 2026-06-18 | Beam Therapeutics Inc. | Methods and compositions for editing a gene associated with galactosemia |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880635B1 (en) | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| JPH0825869B2 (ja) | 1987-02-09 | 1996-03-13 | 株式会社ビタミン研究所 | 抗腫瘍剤包埋リポソ−ム製剤 |
| US4917951A (en) | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US5846946A (en) | 1996-06-14 | 1998-12-08 | Pasteur Merieux Serums Et Vaccins | Compositions and methods for administering Borrelia DNA |
| US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6503717B2 (en) | 1999-12-06 | 2003-01-07 | Sangamo Biosciences, Inc. | Methods of using randomized libraries of zinc finger proteins for the identification of gene function |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| JP2003514564A (ja) | 1999-11-24 | 2003-04-22 | エムシーエス マイクロ キャリア システムズ ゲーエムベーハー | 核局在化シグナルまたはタンパク質導入領域の多量体を含むポリペプチド、および分子を細胞内へ移入するためのその使用法 |
| AU2001250774B2 (en) | 2000-02-08 | 2005-01-27 | Sangamo Biosciences, Inc. | Cells expressing zinc finger proteins for drug discovery |
| EP2397490B1 (en) | 2004-07-16 | 2013-09-04 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Vaccine constructs and combinations of vaccines designed to improve the breadth of the immune response to diverse strains and clades of HIV |
| JP2011512326A (ja) | 2007-12-31 | 2011-04-21 | ナノコア セラピューティクス，インコーポレイテッド | 心不全の治療用のｒｎａ干渉 |
| HUE041426T2 (hu) | 2009-11-02 | 2019-05-28 | Univ Washington | Terápiás nukleáz-készítmények és eljárások |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
| CN111206032B (zh) * | 2013-12-12 | 2024-07-19 | 布罗德研究所有限公司 | 用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用 |
| WO2015191693A2 (en) * | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| AU2016226077B2 (en) * | 2015-03-03 | 2021-12-23 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases with altered PAM specificity |
| WO2017070632A2 (en) * | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2017093804A2 (en) * | 2015-12-01 | 2017-06-08 | Crispr Therapeutics Ag | Materials and methods for treatment of alpha-1 antitrypsin deficiency |
| EP3433364A1 (en) * | 2016-03-25 | 2019-01-30 | Editas Medicine, Inc. | Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency |
| EP3445853A1 (en) * | 2016-04-19 | 2019-02-27 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
| CA3026110A1 (en) * | 2016-04-19 | 2017-11-02 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
| KR20260004568A (ko) * | 2016-04-19 | 2026-01-08 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신규한 crispr 효소 및 시스템 |
| WO2018027078A1 (en) * | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| WO2018041973A1 (en) | 2016-09-01 | 2018-03-08 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| CN107043779B (zh) * | 2016-12-01 | 2020-05-12 | 中国农业科学院作物科学研究所 | 一种CRISPR/nCas9介导的定点碱基替换在植物中的应用 |
| WO2019040650A1 (en) * | 2017-08-23 | 2019-02-28 | The General Hospital Corporation | GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES HAVING MODIFIED PAM SPECIFICITY |
| CA3082251A1 (en) * | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
-
2019
- 2019-05-11 KR KR1020207035001A patent/KR102853088B1/ko active Active
- 2019-05-11 AU AU2019266326A patent/AU2019266326B2/en active Active
- 2019-05-11 CA CA3100034A patent/CA3100034A1/en active Pending
- 2019-05-11 KR KR1020267013211A patent/KR20260079354A/ko active Pending
- 2019-05-11 US US17/054,324 patent/US20210380955A1/en active Pending
- 2019-05-11 AU AU2019266327A patent/AU2019266327B2/en active Active
- 2019-05-11 JP JP2021513764A patent/JP2021523738A/ja active Pending
- 2019-05-11 KR KR1020257028616A patent/KR20250133482A/ko active Pending
- 2019-05-11 EP EP19799854.5A patent/EP3790595A4/en active Pending
- 2019-05-11 WO PCT/US2019/031899 patent/WO2019217944A1/en not_active Ceased
- 2019-05-11 EP EP19799484.1A patent/EP3790963A4/en active Pending
- 2019-05-11 US US17/054,348 patent/US20230159956A1/en active Pending
- 2019-05-11 KR KR1020207035000A patent/KR102959498B1/ko active Active
- 2019-05-11 CN CN201980046479.3A patent/CN112469446B/zh active Active
- 2019-05-11 CN CN202411723844.9A patent/CN119587720A/zh active Pending
- 2019-05-11 JP JP2021513765A patent/JP7596259B2/ja active Active
- 2019-05-11 CA CA3100037A patent/CA3100037A1/en active Pending
- 2019-05-11 WO PCT/US2019/031898 patent/WO2019217943A1/en not_active Ceased
- 2019-05-11 CN CN201980046538.7A patent/CN112469824A/zh active Pending
-
2024
- 2024-06-13 JP JP2024095618A patent/JP2024147545A/ja active Pending
- 2024-06-13 JP JP2024095566A patent/JP2024138268A/ja active Pending
-
2026
- 2026-05-25 AU AU2026204007A patent/AU2026204007A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024138268A5 (enExample) | ||
| JP2021523737A5 (enExample) | ||
| JP2021523738A5 (enExample) | ||
| JP2021523736A5 (enExample) | ||
| JP2025026840A5 (enExample) | ||
| JP2022519761A5 (enExample) | ||
| An et al. | TET family dioxygenases and DNA demethylation in stem cells and cancers | |
| Wang et al. | Arabidopsis flower and embryo developmental genes are repressed in seedlings by different combinations of polycomb group proteins in association with distinct sets of cis-regulatory elements | |
| JP2017510542A5 (enExample) | ||
| Rosikiewicz et al. | Biological functions of natural antisense transcripts | |
| CA3202977A1 (en) | Compositions and methods for epigenetic editing | |
| JP2016512691A5 (enExample) | ||
| JP2022546608A5 (enExample) | ||
| JP2026012785A (ja) | 細胞ゲノムにおける、相同組換え修復（ｈｄｒ）の効率を上昇させるための方法 | |
| JP2020510439A5 (enExample) | ||
| JP2022532139A5 (enExample) | ||
| IL294014B1 (en) | Nucleobase editors and uses thereof | |
| JP2022519882A5 (enExample) | ||
| JP2019508051A5 (enExample) | ||
| JP2020524497A5 (enExample) | ||
| GB2556276A (en) | Engineered crispr-CAS9 compositions and methods of use | |
| JP2018532705A5 (enExample) | ||
| Mastrototaro et al. | Epigenetic mistakes in neurodevelopmental disorders | |
| Wu et al. | Progress in the application of CRISPR: from gene to base editing | |
| WO2021020884A3 (ko) | 사이토신 염기교정용 조성물 및 이의 용도 |