|
US20030044787A1
(en)
|
2000-05-16 |
2003-03-06 |
Joung J. Keith |
Methods and compositions for interaction trap assays
|
|
US7476500B1
(en)
|
2001-03-19 |
2009-01-13 |
President And Fellows Of Harvard College |
In vivo selection system for enzyme activity
|
|
NZ597299A
(en)
|
2005-08-26 |
2013-03-28 |
Dupont Nutrition Biosci Aps |
Use of a cas gene in combination with CRISPR repeats for modulating resistance in a cell
|
|
WO2010011961A2
(en)
|
2008-07-25 |
2010-01-28 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic rnai-like system and methods of use
|
|
AU2009283194B2
(en)
|
2008-08-22 |
2014-10-16 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted single-stranded cleavage and targeted integration
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
US9404098B2
(en)
|
2008-11-06 |
2016-08-02 |
University Of Georgia Research Foundation, Inc. |
Method for cleaving a target RNA using a Cas6 polypeptide
|
|
WO2011091324A2
(en)
|
2010-01-22 |
2011-07-28 |
The Scripps Research Institute |
Methods of generating zinc finger nucleases having altered activity
|
|
CA2825370A1
(en)
|
2010-12-22 |
2012-06-28 |
President And Fellows Of Harvard College |
Continuous directed evolution
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
LT3401400T
(lt)
*
|
2012-05-25 |
2019-06-10 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui
|
|
WO2013188638A2
(en)
|
2012-06-15 |
2013-12-19 |
The Regents Of The University Of California |
Endoribonucleases and methods of use thereof
|
|
JP2015527889A
(ja)
|
2012-07-25 |
2015-09-24 |
ザ ブロード インスティテュート， インコーポレイテッド |
誘導可能なｄｎａ結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用
|
|
WO2014022702A2
(en)
|
2012-08-03 |
2014-02-06 |
The Regents Of The University Of California |
Methods and compositions for controlling gene expression by rna processing
|
|
PL4397760T3
(pl)
|
2012-10-23 |
2026-03-30 |
Toolgen Incorporated |
Kompozycja do rozszczepiania docelowego dna zawierająca prowadzące rna specyficzne dla docelowego dna i kwas nukleinowy kodujący białko cas lub białko cas oraz jej zastosowanie
|
|
US20160010154A1
(en)
|
2012-11-30 |
2016-01-14 |
The Parkinson's Institute |
Screening assays for therapeutics for parkinson's disease
|
|
EP3135765A1
(en)
|
2012-12-06 |
2017-03-01 |
Sigma-Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
WO2014093479A1
(en)
|
2012-12-11 |
2014-06-19 |
Montana State University |
Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation
|
|
CN114634950A
(zh)
|
2012-12-12 |
2022-06-17 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
JP2016504026A
(ja)
|
2012-12-12 |
2016-02-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための系、方法および最適化ガイド組成物のエンジニアリング
|
|
IL239317B
(en)
|
2012-12-12 |
2022-07-01 |
Broad Inst Inc |
Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP2896697B1
(en)
|
2012-12-12 |
2015-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
SG10201912991WA
(en)
|
2012-12-17 |
2020-03-30 |
Harvard College |
Rna-guided human genome engineering
|
|
EP3919505B1
(en)
|
2013-01-16 |
2023-08-30 |
Emory University |
Uses of cas9-nucleic acid complexes
|
|
SG11201507378UA
(en)
|
2013-03-14 |
2015-10-29 |
Caribou Biosciences Inc |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US10378027B2
(en)
|
2013-03-15 |
2019-08-13 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
JP2016522679A
(ja)
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用
|
|
EP3730615A3
(en)
|
2013-05-15 |
2020-12-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
US11414695B2
(en)
|
2013-05-29 |
2022-08-16 |
Agilent Technologies, Inc. |
Nucleic acid enrichment using Cas9
|
|
ES2670531T3
(es)
|
2013-05-29 |
2018-05-30 |
Cellectis S.A. |
Un método para producir una escisión de ADN precisa utilizando la actividad nickasa de Cas9
|
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
|
EP3004339B1
(en)
|
2013-05-29 |
2021-07-07 |
Cellectis |
New compact scaffold of cas9 in the type ii crispr system
|
|
SG10201710030QA
(en)
|
2013-06-04 |
2018-01-30 |
Harvard College |
Rna-guided transcriptional regulation
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
ES3029138T3
(en)
|
2013-06-05 |
2025-06-23 |
Univ Duke |
Rna-guided gene editing and gene regulation
|
|
JP6738729B2
(ja)
|
2013-06-17 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
CN105793425B
(zh)
|
2013-06-17 |
2021-10-26 |
布罗德研究所有限公司 |
使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたＣＲＩＳＰＲ−Ｃａｓ二重ニッカーゼ系、方法および組成物
|
|
KR20260047646A
(ko)
|
2013-07-09 |
2026-04-08 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
멀티플렉스 rna-가이드된 게놈 조작
|
|
BR112016000571B1
(pt)
|
2013-07-10 |
2023-12-26 |
President And Fellows Of Harvard College |
Métodos in vitro para modular a expressão e para alterar um ou mais ácidos nucleicos alvo em uma célula simultaneamente com a regulação da expressão de um ou mais ácidos nucleicos alvo em uma célula, bem como célula de levedura ou bactéria compreendendo ácidos nucleicos
|
|
JP6482546B2
(ja)
|
2013-07-19 |
2019-03-13 |
ラリクス・バイオサイエンス・リミテッド・ライアビリティ・カンパニーＬａｒｉｘ Ｂｉｏｓｃｉｅｎｃｅ， Ｌｌｃ |
二重対立遺伝子ノックアウトを生成するための方法および組成物
|
|
US10563225B2
(en)
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US20150044772A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
Crispr/cas system-based novel fusion protein and its applications in genome editing
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
WO2015048577A2
(en)
|
2013-09-27 |
2015-04-02 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
|
WO2015089427A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
CA2932948A1
(en)
|
2013-12-13 |
2015-06-18 |
Cellectis |
New method of selection of algal-transformed cells using nuclease
|
|
WO2015103153A1
(en)
|
2013-12-31 |
2015-07-09 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
|
KR102595473B1
(ko)
|
2014-04-18 |
2023-10-30 |
에디타스 메디신, 인코포레이티드 |
암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분
|
|
EP3151846A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
DK3180426T3
(da)
|
2014-08-17 |
2020-03-30 |
Broad Inst Inc |
Genomredigering ved anvendelse af cas9-nickaser
|
|
WO2016073990A2
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
CA2968440A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
EP3224353B9
(en)
|
2014-11-26 |
2023-08-09 |
Technology Innovation Momentum Fund (Israel) Limited Partnership |
Targeted elimination of bacterial genes
|
|
DK3234150T3
(da)
|
2014-12-16 |
2025-11-03 |
Danisco Us Inc |
Systemer til svampegenommodificering og fremgangsmåder til anvendelse deraf
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
US20180155708A1
(en)
|
2015-01-08 |
2018-06-07 |
President And Fellows Of Harvard College |
Split Cas9 Proteins
|
|
EP3245232B1
(en)
|
2015-01-12 |
2021-04-21 |
The Regents of The University of California |
Heterodimeric cas9 and methods of use thereof
|
|
SI3250691T1
(sl)
|
2015-01-28 |
2023-10-30 |
Caribou Biosciences, Inc. |
Hibridni dna/rna-polinukleotidi crispr in postopki za uporabo
|
|
JP6817215B2
(ja)
|
2015-03-03 |
2021-01-20 |
ザ ジェネラル ホスピタル コーポレイション |
変更ＰＡＭ特異性を有する遺伝子操作ＣＲＩＳＰＲ−Ｃａｓ９ヌクレアーゼ
|
|
EP3277805B1
(en)
|
2015-03-31 |
2025-05-07 |
SOHM, Inc. |
Cas 9 retroviral integrase systems for targeted incorporation of a dna sequence into a genome of a cell
|
|
US11214779B2
(en)
|
2015-04-08 |
2022-01-04 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Activatable CRISPR/CAS9 for spatial and temporal control of genome editing
|
|
JP6892642B2
(ja)
|
2015-04-13 |
2021-06-23 |
国立大学法人 東京大学 |
光依存的に又は薬物存在下でヌクレアーゼ活性若しくはニッカーゼ活性を示す、又は標的遺伝子の発現を抑制若しくは活性化するポリペプチドのセット
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
CN106011104B
(zh)
|
2015-05-21 |
2019-09-27 |
清华大学 |
利用拆分Cas系统进行基因编辑和表达调控方法
|
|
EP3303634B1
(en)
|
2015-06-03 |
2023-08-30 |
The Regents of The University of California |
Cas9 variants and methods of use thereof
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
EP3436575A1
(en)
|
2015-06-18 |
2019-02-06 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
IL293323B2
(en)
|
2015-06-18 |
2024-01-01 |
Massachusetts Inst Technology |
Crispr enzyme mutations reducing off-target effects
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
WO2017015015A1
(en)
|
2015-07-17 |
2017-01-26 |
Emory University |
Crispr-associated protein from francisella and uses related thereto
|
|
WO2017019895A1
(en)
|
2015-07-30 |
2017-02-02 |
President And Fellows Of Harvard College |
Evolution of talens
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016316845B2
(en)
|
2015-08-28 |
2022-03-10 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017048969A1
(en)
|
2015-09-17 |
2017-03-23 |
The Regents Of The University Of California |
Variant cas9 polypeptides comprising internal insertions
|
|
CA2998287A1
(en)
|
2015-09-24 |
2017-04-20 |
Crispr Therapeutics Ag |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
|
CN108778343A
(zh)
|
2015-10-16 |
2018-11-09 |
天普大学-联邦高等教育系统 |
利用cpf1进行rna向导的基因编辑的方法和组合物
|
|
CN109153980B
(zh)
|
2015-10-22 |
2023-04-14 |
布罗德研究所有限公司 |
Vi-b型crispr酶和系统
|
|
SG10202104041PA
(en)
|
2015-10-23 |
2021-06-29 |
Harvard College |
Nucleobase editors and uses thereof
|
|
EP3374501B1
(en)
|
2015-11-11 |
2023-07-12 |
Lonza Ltd |
Crispr-associated (cas) proteins with reduced immunogenicity
|
|
WO2017099494A1
(ko)
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
|
EP3405570A1
(en)
|
2016-01-22 |
2018-11-28 |
The Broad Institute, Inc. |
Crystal structure of crispr cpf1
|
|
WO2017136335A1
(en)
|
2016-02-01 |
2017-08-10 |
The Regents Of The University Of California |
Self-inactivating endonuclease-encoding nucleic acids and methods of using the same
|
|
US9896696B2
(en)
|
2016-02-15 |
2018-02-20 |
Benson Hill Biosystems, Inc. |
Compositions and methods for modifying genomes
|
|
US20200291370A1
(en)
|
2016-03-18 |
2020-09-17 |
President And Fellows Of Harvard College |
Mutant Cas Proteins
|
|
WO2017181107A2
(en)
|
2016-04-16 |
2017-10-19 |
Ohio State Innovation Foundation |
Modified cpf1 mrna, modified guide rna, and uses thereof
|
|
SG11201810179RA
(en)
|
2016-04-19 |
2018-12-28 |
Broad Inst Inc |
Novel crispr enzymes and systems
|
|
US20200263190A1
(en)
|
2016-04-19 |
2020-08-20 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2017196768A1
(en)
|
2016-05-09 |
2017-11-16 |
President And Fellows Of Harvard College |
Self-targeting guide rnas in crispr system
|
|
WO2017197238A1
(en)
|
2016-05-12 |
2017-11-16 |
President And Fellows Of Harvard College |
Aav split cas9 genome editing and transcriptional regulation
|
|
US11788083B2
(en)
|
2016-06-17 |
2023-10-17 |
The Broad Institute, Inc. |
Type VI CRISPR orthologs and systems
|
|
WO2017219033A1
(en)
|
2016-06-17 |
2017-12-21 |
Montana State University |
Bidirectional targeting for genome editing
|
|
WO2017222773A1
(en)
|
2016-06-20 |
2017-12-28 |
Pioneer Hi-Bred International, Inc. |
Novel cas systems and methods of use
|
|
US10927383B2
(en)
|
2016-06-30 |
2021-02-23 |
Ethris Gmbh |
Cas9 mRNAs
|
|
US11168313B2
(en)
|
2016-07-26 |
2021-11-09 |
The General Hospital Corporation |
Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)
|
|
WO2018035388A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
WO2018049075A1
(en)
|
2016-09-07 |
2018-03-15 |
Flagship Pioneering, Inc. |
Methods and compositions for modulating gene expression
|
|
US12188059B2
(en)
|
2016-09-13 |
2025-01-07 |
The Broad Institute, Inc. |
Proximity-dependent biotinylation and uses thereof
|
|
WO2018052247A1
(ko)
|
2016-09-13 |
2018-03-22 |
주식회사 툴젠 |
시토신 디아미나제에 의한 dna에서의 염기 교정 확인 방법
|
|
JP2019532644A
(ja)
|
2016-09-30 |
2019-11-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｒｎａ誘導型核酸修飾酵素及びその使用方法
|
|
WO2018064352A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
US11242542B2
(en)
|
2016-10-07 |
2022-02-08 |
Integrated Dna Technologies, Inc. |
S. pyogenes Cas9 mutant genes and polypeptides encoded by same
|
|
CA3039409A1
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
IT201600102542A1
(it)
|
2016-10-12 |
2018-04-12 |
Univ Degli Studi Di Trento |
Plasmide e sistema lentivirale contenente un circuito autolimitante della Cas9 che ne incrementa la sicurezza.
|
|
EP3525832A4
(en)
|
2016-10-14 |
2020-04-29 |
The General Hospital Corp. |
Epigenetically regulated site-specific nucleases
|
|
SG11201903089RA
(en)
|
2016-10-14 |
2019-05-30 |
Harvard College |
Aav delivery of nucleobase editors
|
|
SG10201913505WA
(en)
|
2016-10-17 |
2020-02-27 |
Univ Nanyang Tech |
Truncated crispr-cas proteins for dna targeting
|
|
US11180778B2
(en)
|
2016-11-11 |
2021-11-23 |
The Regents Of The University Of California |
Variant RNA-guided polypeptides and methods of use
|
|
AU2017364084B2
(en)
|
2016-11-22 |
2024-07-04 |
Integrated Dna Technologies, Inc. |
CRISPR/Cpf1 systems and methods
|
|
US11674128B2
(en)
|
2016-12-12 |
2023-06-13 |
Tsinghua University |
Engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by enhanced guide RNA
|
|
EA201991443A1
(ru)
|
2016-12-14 |
2020-01-14 |
Вагенинген Университейт |
ТЕРМОСТАБИЛЬНЫЕ НУКЛЕАЗЫ Cas9
|
|
EP3555284B1
(en)
|
2016-12-16 |
2021-12-01 |
The Rockefeller University |
Compositions and methods using cas9 with enhanced spacer acquisition function
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
EP3889258A1
(en)
|
2016-12-19 |
2021-10-06 |
Editas Medicine, Inc. |
Emulsion-based screening methods
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
IT201700016321A1
(it)
*
|
2017-02-14 |
2018-08-14 |
Univ Degli Studi Di Trento |
Mutanti di cas9 ad alta specificita' e loro applicazioni.
|
|
US11111492B2
(en)
|
2017-03-06 |
2021-09-07 |
Florida State University Research Foundation, Inc. |
Genome engineering methods using a cytosine-specific Cas9
|
|
US11332727B2
(en)
|
2017-03-14 |
2022-05-17 |
The Regents Of The University Of California |
Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector
|
|
CN110914433A
(zh)
|
2017-03-24 |
2020-03-24 |
库尔维科公司 |
编码crispr相关蛋白质的核酸及其用途
|
|
WO2018183766A1
(en)
|
2017-03-29 |
2018-10-04 |
Editas Medicine, Inc. |
Selection methods
|
|
CN108690845B
(zh)
|
2017-04-10 |
2021-04-27 |
中国科学院动物研究所 |
基因组编辑系统和方法
|
|
US20180362590A1
(en)
|
2017-04-14 |
2018-12-20 |
Synthetic Genomics, Inc. |
Polypeptides with type v crispr activity and uses thereof
|
|
CN110799205A
(zh)
|
2017-04-21 |
2020-02-14 |
通用医疗公司 |
利用CRISPR-Cpf1的可诱导、可调和多重的人类基因调节
|
|
ES2992912T3
(en)
|
2017-04-21 |
2024-12-19 |
Massachusetts Gen Hospital |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
WO2018197495A1
(en)
|
2017-04-24 |
2018-11-01 |
Dupont Nutrition Biosciences Aps |
Novel anti-crispr genes and proteins and methods of use
|
|
WO2018213351A1
(en)
|
2017-05-16 |
2018-11-22 |
The Regents Of The University Of California |
Thermostable rna-guided endonucleases and methods of use thereof
|
|
EP3625338A4
(en)
|
2017-05-19 |
2021-01-20 |
Tsinghua University |
CONSTRUCTION OF A MINIMAL SACAS9-CRISPR / CAS SYSTEM FOR GENEDITATION AND TRANSCRIPTION REGULATION, OPTIMIZED BY EXTENDED GUIDE-RNA
|
|
CN110914423B
(zh)
|
2017-05-31 |
2024-02-06 |
国立大学法人东京大学 |
经修饰的Cas9蛋白及其用途
|
|
US20200140835A1
(en)
|
2017-06-06 |
2020-05-07 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 Nucleases
|
|
JP7518620B2
(ja)
|
2017-06-09 |
2024-07-18 |
エディタス・メディシン，インコーポレイテッド |
操作されたｃａｓ９ヌクレアーゼ
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
BR112020000310A2
(pt)
|
2017-07-07 |
2020-07-14 |
Toolgen Incorporated |
variantes de crispr alvo específicas
|
|
US11208640B2
(en)
|
2017-07-21 |
2021-12-28 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Modulating human Cas9-specific host immune response
|
|
CA3072960A1
(en)
|
2017-08-15 |
2019-02-21 |
Intellia Therapeutics, Inc. |
Stabilized nucleic acids encoding messenger ribonucleic acid (mrna)
|
|
CA3073448A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
EP3676378A4
(en)
|
2017-08-31 |
2021-06-09 |
The New York Genome Center |
PROCEDURES AND COMPOSITIONS USING CRIMP-CPF1 AND PAIRED GUIDE-CRISPR-RNA FOR PROGRAMMABLE GENOMIC DELETIONS
|
|
US11530396B2
(en)
|
2017-09-05 |
2022-12-20 |
The University Of Tokyo |
Modified CAS9 protein, and use thereof
|
|
WO2019051419A1
(en)
|
2017-09-08 |
2019-03-14 |
University Of North Texas Health Science Center |
Engineered cas9 variants
|
|
WO2019060469A2
(en)
|
2017-09-19 |
2019-03-28 |
Massachusetts Institute Of Technology |
CAS9 STREPTOCOCCUS CANIS AS A GENOMIC ENGINEERING PLATFORM WITH NEW PAM SPECIFICITY
|
|
CA3111479A1
(en)
|
2017-09-26 |
2019-04-04 |
The Board Of Trustees Of The University Of Illinois |
Crispr/cas system and method for genome editing and modulating transcription
|
|
GB201716590D0
(en)
|
2017-10-10 |
2017-11-22 |
Univ Wageningen |
Thermostable cas9 nucleases with reduced off-target activity
|
|
WO2019083532A1
(en)
|
2017-10-26 |
2019-05-02 |
Excision Biotherapeutics Inc |
IDENTIFICATION OF GENE EDITION PROTEINS AND GENE EXCISION (TYPE CAS9 AND ARGONAUTE) FROM OTHER ORGANISMS
|
|
US20200339967A1
(en)
|
2017-11-01 |
2020-10-29 |
The Regents Of The University Of California |
Cas12c compositions and methods of use
|
|
US12227753B2
(en)
|
2017-11-01 |
2025-02-18 |
The Regents Of The University Of California |
CasY compositions and methods of use
|
|
AU2018358051B2
(en)
|
2017-11-01 |
2025-01-09 |
The Regents Of The University Of California |
CasZ compositions and methods of use
|
|
US11970719B2
(en)
|
2017-11-01 |
2024-04-30 |
The Regents Of The University Of California |
Class 2 CRISPR/Cas compositions and methods of use
|
|
WO2019090173A1
(en)
|
2017-11-02 |
2019-05-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
|
US20210032622A1
(en)
|
2017-11-09 |
2021-02-04 |
Crispr Therapeutics Ag |
Self-inactivating (sin) crispr/cas or crispr/cpf1 systems and uses thereof
|
|
EP3707252A1
(en)
|
2017-11-10 |
2020-09-16 |
Novozymes A/S |
Temperature-sensitive cas9 protein
|
|
WO2019099943A1
(en)
|
2017-11-16 |
2019-05-23 |
Astrazeneca Ab |
Compositions and methods for improving the efficacy of cas9-based knock-in strategies
|
|
US20200392473A1
(en)
|
2017-12-22 |
2020-12-17 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
WO2019126709A1
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted dna base editing
|
|
US20210071163A1
(en)
|
2017-12-22 |
2021-03-11 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted rna base editing
|
|
WO2019126762A2
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Cas12a systems, methods, and compositions for targeted rna base editing
|
|
WO2019168953A1
(en)
|
2018-02-27 |
2019-09-06 |
President And Fellows Of Harvard College |
Evolved cas9 variants and uses thereof
|
|
PT3765616T
(pt)
|
2018-03-14 |
2023-08-28 |
Arbor Biotechnologies Inc |
Novas enzimas e sistemas de direcionamento de dna e rna crispr
|
|
AU2019236210B2
(en)
|
2018-03-14 |
2025-07-03 |
Arbor Biotechnologies, Inc. |
Novel CRISPR DNA targeting enzymes and systems
|
|
JP7550648B2
(ja)
|
2018-03-19 |
2024-09-13 |
クリスパー セラピューティクス アーゲー |
新規ｒｎａプログラム可能エンドヌクレアーゼ系およびその使用
|