|
WO2001088197A2
(en)
|
2000-05-16 |
2001-11-22 |
Massachusetts Institute Of Technology |
Methods and compositions for interaction trap assays
|
|
US7476500B1
(en)
|
2001-03-19 |
2009-01-13 |
President And Fellows Of Harvard College |
In vivo selection system for enzyme activity
|
|
EP2325332B1
(en)
|
2005-08-26 |
2012-10-31 |
DuPont Nutrition Biosciences ApS |
Use of CRISPR associated genes (CAS)
|
|
WO2010011961A2
(en)
|
2008-07-25 |
2010-01-28 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic rnai-like system and methods of use
|
|
KR20160015400A
(ko)
|
2008-08-22 |
2016-02-12 |
상가모 바이오사이언스 인코포레이티드 |
표적화된 단일가닥 분할 및 표적화된 통합을 위한 방법 및 조성물
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
WO2010054108A2
(en)
|
2008-11-06 |
2010-05-14 |
University Of Georgia Research Foundation, Inc. |
Cas6 polypeptides and methods of use
|
|
WO2011091324A2
(en)
|
2010-01-22 |
2011-07-28 |
The Scripps Research Institute |
Methods of generating zinc finger nucleases having altered activity
|
|
JP6088438B2
(ja)
|
2010-12-22 |
2017-03-01 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
連続的定向進化
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
FI3597749T3
(fi)
|
2012-05-25 |
2023-10-09 |
Univ California |
Menetelmiä ja koostumuksia rna-ohjattua kohde-dna-modifikaatiota varten ja rna-ohjattua transkription modulaatiota varten
|
|
WO2013188638A2
(en)
|
2012-06-15 |
2013-12-19 |
The Regents Of The University Of California |
Endoribonucleases and methods of use thereof
|
|
EP2877213B1
(en)
|
2012-07-25 |
2020-12-02 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
|
EP2880171B1
(en)
|
2012-08-03 |
2018-10-03 |
The Regents of The University of California |
Methods and compositions for controlling gene expression by rna processing
|
|
KR101656236B1
(ko)
|
2012-10-23 |
2016-09-12 |
주식회사 툴젠 |
표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도
|
|
US20160010154A1
(en)
|
2012-11-30 |
2016-01-14 |
The Parkinson's Institute |
Screening assays for therapeutics for parkinson's disease
|
|
PT3363902T
(pt)
|
2012-12-06 |
2019-12-19 |
Sigma Aldrich Co Llc |
Modificação e regulação de genoma baseadas em crispr
|
|
WO2014093479A1
(en)
|
2012-12-11 |
2014-06-19 |
Montana State University |
Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP2932421A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
KR20150105956A
(ko)
|
2012-12-12 |
2015-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
PT2784162E
(pt)
|
2012-12-12 |
2015-08-27 |
Broad Inst Inc |
Engenharia de sistemas, métodos e composições guia otimizadas para a manipulação de sequências
|
|
EP4234696A3
(en)
|
2012-12-12 |
2023-09-06 |
The Broad Institute Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP4282970A3
(en)
|
2012-12-17 |
2024-01-17 |
President and Fellows of Harvard College |
Rna-guided human genome engineering
|
|
EP3919505B1
(en)
|
2013-01-16 |
2023-08-30 |
Emory University |
Uses of cas9-nucleic acid complexes
|
|
AU2014235794A1
(en)
|
2013-03-14 |
2015-10-22 |
Caribou Biosciences, Inc. |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
KR102874079B1
(ko)
|
2013-03-15 |
2025-10-22 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
|
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
EP2981617B1
(en)
|
2013-04-04 |
2023-07-05 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
AU2014265331B2
(en)
|
2013-05-15 |
2019-12-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
EP3004349B1
(en)
|
2013-05-29 |
2018-03-28 |
Cellectis S.A. |
A method for producing precise dna cleavage using cas9 nickase activity
|
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
|
US9873907B2
(en)
|
2013-05-29 |
2018-01-23 |
Agilent Technologies, Inc. |
Method for fragmenting genomic DNA using CAS9
|
|
US11685935B2
(en)
|
2013-05-29 |
2023-06-27 |
Cellectis |
Compact scaffold of Cas9 in the type II CRISPR system
|
|
RU2690935C2
(ru)
|
2013-06-04 |
2019-06-06 |
Президент Энд Фэллоуз Оф Харвард Коллидж |
Направляемая рнк регуляция транскрипции
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
JP7085716B2
(ja)
|
2013-06-05 |
2022-06-17 |
デューク ユニバーシティ |
Rnaガイド遺伝子編集及び遺伝子調節
|
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
JP6738729B2
(ja)
|
2013-06-17 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
|
CA2917638C
(en)
|
2013-07-09 |
2024-09-10 |
Harvard College |
RNA MULTIPLEX GUIDED GENOMIC ENGINEERING
|
|
SG10201800213VA
(en)
|
2013-07-10 |
2018-02-27 |
Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
WO2015010114A1
(en)
|
2013-07-19 |
2015-01-22 |
Larix Bioscience, Llc |
Methods and compositions for producing double allele knock outs
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US20160237455A1
(en)
|
2013-09-27 |
2016-08-18 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
|
JP2017503485A
(ja)
|
2013-12-12 |
2017-02-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
遺伝子産物の発現、構造情報、及び誘導性モジュラーcas酵素を変更するためのcrispr−cas系並びに方法
|
|
SG10201804973TA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Compositions and Methods of Use of Crispr-Cas Systems in Nucleotide Repeat Disorders
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
EP3080275B1
(en)
|
2013-12-13 |
2020-01-15 |
Cellectis |
Method of selection of transformed diatoms using nuclease
|
|
US9963689B2
(en)
|
2013-12-31 |
2018-05-08 |
The Regents Of The University Of California |
Cas9 crystals and methods of use thereof
|
|
WO2015161276A2
(en)
|
2014-04-18 |
2015-10-22 |
Editas Medicine, Inc. |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
|
EP3152319A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
EP3180426B1
(en)
|
2014-08-17 |
2019-12-25 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
AU2015342749B2
(en)
|
2014-11-07 |
2022-01-27 |
Editas Medicine, Inc. |
Methods for improving CRISPR/Cas-mediated genome-editing
|
|
CA3176380A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
WO2016084088A1
(en)
|
2014-11-26 |
2016-06-02 |
Ramot At Tel-Aviv University Ltd. |
Targeted elimination of bacterial genes
|
|
US11427829B2
(en)
|
2014-12-16 |
2022-08-30 |
Danisco Us Inc |
Fungal genome modification systems and methods of use
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
EP3237615B2
(en)
|
2014-12-24 |
2023-07-26 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
US20180155708A1
(en)
|
2015-01-08 |
2018-06-07 |
President And Fellows Of Harvard College |
Split Cas9 Proteins
|
|
WO2016114972A1
(en)
|
2015-01-12 |
2016-07-21 |
The Regents Of The University Of California |
Heterodimeric cas9 and methods of use thereof
|
|
RU2713328C2
(ru)
|
2015-01-28 |
2020-02-04 |
Пайонир Хай-Бред Интернэшнл, Инк. |
Гибридные днк/рнк-полинуклеотиды crispr и способы применения
|
|
KR102598856B1
(ko)
|
2015-03-03 |
2023-11-07 |
더 제너럴 하스피탈 코포레이션 |
변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제
|
|
EP4600366A3
(en)
|
2015-03-31 |
2025-10-22 |
SOHM, Inc. |
Cas 9 retroviral integrase systems for targeted incorporation of a dna sequence into a genome of a cell
|
|
WO2016164797A1
(en)
|
2015-04-08 |
2016-10-13 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Activatable crispr/cas9 for spatial and temporal control of genome editing
|
|
EP3284749B1
(en)
|
2015-04-13 |
2024-08-14 |
The University of Tokyo |
Set of polypeptides exhibiting nuclease activity or nickase activity with dependence on light or in presence of drug or suppressing or activating expression of target gene
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
CN106011104B
(zh)
|
2015-05-21 |
2019-09-27 |
清华大学 |
利用拆分Cas系统进行基因编辑和表达调控方法
|
|
EP3303634B1
(en)
|
2015-06-03 |
2023-08-30 |
The Regents of The University of California |
Cas9 variants and methods of use thereof
|
|
AU2016279062A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
CN109536474A
(zh)
|
2015-06-18 |
2019-03-29 |
布罗德研究所有限公司 |
降低脱靶效应的crispr酶突变
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
WO2017015015A1
(en)
|
2015-07-17 |
2017-01-26 |
Emory University |
Crispr-associated protein from francisella and uses related thereto
|
|
WO2017019895A1
(en)
|
2015-07-30 |
2017-02-02 |
President And Fellows Of Harvard College |
Evolution of talens
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016316845B2
(en)
*
|
2015-08-28 |
2022-03-10 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017048969A1
(en)
|
2015-09-17 |
2017-03-23 |
The Regents Of The University Of California |
Variant cas9 polypeptides comprising internal insertions
|
|
JP2018532402A
(ja)
|
2015-09-24 |
2018-11-08 |
クリスパー セラピューティクス アーゲー |
Rnaプログラム可能エンドヌクレアーゼの新規のファミリーならびにゲノム編集および他の適用におけるそれらの使用
|
|
CN108778343A
(zh)
|
2015-10-16 |
2018-11-09 |
天普大学-联邦高等教育系统 |
利用cpf1进行rna向导的基因编辑的方法和组合物
|
|
KR102761827B1
(ko)
|
2015-10-22 |
2025-02-03 |
더 브로드 인스티튜트, 인코퍼레이티드 |
타입 vi-b crispr 효소 및 시스템
|
|
US12043852B2
(en)
*
|
2015-10-23 |
2024-07-23 |
President And Fellows Of Harvard College |
Evolved Cas9 proteins for gene editing
|
|
EP3374501B1
(en)
|
2015-11-11 |
2023-07-12 |
Lonza Ltd |
Crispr-associated (cas) proteins with reduced immunogenicity
|
|
WO2017099494A1
(ko)
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
|
WO2017127807A1
(en)
|
2016-01-22 |
2017-07-27 |
The Broad Institute Inc. |
Crystal structure of crispr cpf1
|
|
US11530421B2
(en)
|
2016-02-01 |
2022-12-20 |
The Regents Of The University Of California |
Self-inactivating endonuclease-encoding nucleic acids and methods of using the same
|
|
US9896696B2
(en)
|
2016-02-15 |
2018-02-20 |
Benson Hill Biosystems, Inc. |
Compositions and methods for modifying genomes
|
|
US20200291370A1
(en)
|
2016-03-18 |
2020-09-17 |
President And Fellows Of Harvard College |
Mutant Cas Proteins
|
|
US12065667B2
(en)
|
2016-04-16 |
2024-08-20 |
Ohio State Innovation Foundation |
Modified Cpf1 MRNA, modified guide RNA, and uses thereof
|
|
WO2017189308A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
KR102424476B1
(ko)
|
2016-04-19 |
2022-07-25 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
US20190161743A1
(en)
|
2016-05-09 |
2019-05-30 |
President And Fellows Of Harvard College |
Self-Targeting Guide RNAs in CRISPR System
|
|
US20190345483A1
(en)
|
2016-05-12 |
2019-11-14 |
President And Fellows Of Harvard College |
AAV Split Cas9 Genome Editing and Transcriptional Regulation
|
|
WO2017219033A1
(en)
|
2016-06-17 |
2017-12-21 |
Montana State University |
Bidirectional targeting for genome editing
|
|
JP7267013B2
(ja)
|
2016-06-17 |
2023-05-01 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
Vi型crisprオルソログ及び系
|
|
CA3018430A1
(en)
|
2016-06-20 |
2017-12-28 |
Pioneer Hi-Bred International, Inc. |
Novel cas systems and methods of use
|
|
US10927383B2
(en)
|
2016-06-30 |
2021-02-23 |
Ethris Gmbh |
Cas9 mRNAs
|
|
EP3491133A4
(en)
|
2016-07-26 |
2020-05-06 |
The General Hospital Corporation |
VARIANTS OF CRISPR OF PREVOTELLA AND FRANCISELLA 1 (CPF1)
|
|
US11352647B2
(en)
|
2016-08-17 |
2022-06-07 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US12431216B2
(en)
|
2016-08-17 |
2025-09-30 |
Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
WO2018049075A1
(en)
|
2016-09-07 |
2018-03-15 |
Flagship Pioneering, Inc. |
Methods and compositions for modulating gene expression
|
|
JP2019526271A
(ja)
|
2016-09-13 |
2019-09-19 |
ツールゲン インコーポレイテッドToolgen Incorporated |
シトシンデアミナーゼによるdnaでの塩基編集確認方法
|
|
US12188059B2
(en)
|
2016-09-13 |
2025-01-07 |
The Broad Institute, Inc. |
Proximity-dependent biotinylation and uses thereof
|
|
JP7306696B2
(ja)
|
2016-09-30 |
2023-07-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Rna誘導型核酸修飾酵素及びその使用方法
|
|
CN110023494A
(zh)
|
2016-09-30 |
2019-07-16 |
加利福尼亚大学董事会 |
Rna指导的核酸修饰酶及其使用方法
|
|
CA3039409A1
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
US11242542B2
(en)
|
2016-10-07 |
2022-02-08 |
Integrated Dna Technologies, Inc. |
S. pyogenes Cas9 mutant genes and polypeptides encoded by same
|
|
IT201600102542A1
(it)
|
2016-10-12 |
2018-04-12 |
Univ Degli Studi Di Trento |
Plasmide e sistema lentivirale contenente un circuito autolimitante della Cas9 che ne incrementa la sicurezza.
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
KR20240064734A
(ko)
|
2016-10-14 |
2024-05-13 |
더 제너럴 하스피탈 코포레이션 |
후성적으로 조절되는 부위-특이적 뉴클레아제
|
|
SG10201913505WA
(en)
|
2016-10-17 |
2020-02-27 |
Univ Nanyang Tech |
Truncated crispr-cas proteins for dna targeting
|
|
WO2018089664A1
(en)
|
2016-11-11 |
2018-05-17 |
The Regents Of The University Of California |
Variant rna-guided polypeptides and methods of use
|
|
JP2019535287A
(ja)
|
2016-11-22 |
2019-12-12 |
インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド |
Crispr/cpf1システム及び方法
|
|
WO2018209712A1
(en)
|
2017-05-19 |
2018-11-22 |
Tsinghua University |
Engineering of a minimal sacas9 crispr/cas system for gene editing and transcriptional regulation optimized by enhanced guide rna
|
|
US11674128B2
(en)
|
2016-12-12 |
2023-06-13 |
Tsinghua University |
Engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by enhanced guide RNA
|
|
CA3046824A1
(en)
|
2016-12-14 |
2018-06-21 |
Wageningen Universiteit |
Thermostable cas9 nucleases
|
|
WO2018109101A1
(en)
|
2016-12-14 |
2018-06-21 |
Wageningen Universiteit |
Thermostable cas9 nucleases
|
|
WO2018112451A1
(en)
|
2016-12-16 |
2018-06-21 |
The Rockefeller University |
Compositions and methods using cas9 with enhanced spacer acquisition function
|
|
WO2018118968A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Emulsion-based screening methods
|
|
US12286727B2
(en)
|
2016-12-19 |
2025-04-29 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
EP3565907B1
(en)
|
2017-01-06 |
2022-05-04 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
IT201700016321A1
(it)
*
|
2017-02-14 |
2018-08-14 |
Univ Degli Studi Di Trento |
Mutanti di cas9 ad alta specificita' e loro applicazioni.
|
|
US11111492B2
(en)
|
2017-03-06 |
2021-09-07 |
Florida State University Research Foundation, Inc. |
Genome engineering methods using a cytosine-specific Cas9
|
|
WO2018170015A1
(en)
|
2017-03-14 |
2018-09-20 |
The Regents Of The University Of California |
Engineering crispr cas9 immune stealth
|
|
US11739335B2
(en)
|
2017-03-24 |
2023-08-29 |
CureVac SE |
Nucleic acids encoding CRISPR-associated proteins and uses thereof
|
|
US20210047633A1
(en)
|
2017-03-29 |
2021-02-18 |
Editas Medicine, Inc. |
Selection methods
|
|
CN108690845B
(zh)
|
2017-04-10 |
2021-04-27 |
中国科学院动物研究所 |
基因组编辑系统和方法
|
|
WO2018191715A2
(en)
|
2017-04-14 |
2018-10-18 |
Synthetic Genomics, Inc. |
Polypeptides with type v crispr activity and uses thereof
|
|
CA3059208A1
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Inducible, tunable, and multiplex human gene regulation using crispr-cpf1
|
|
EP3612551B1
(en)
|
2017-04-21 |
2024-09-04 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US11530405B2
(en)
|
2017-04-24 |
2022-12-20 |
Dupont Nutrition Biosciences Aps |
Anti-CRISPR genes and proteins and methods of use
|
|
US11692184B2
(en)
|
2017-05-16 |
2023-07-04 |
The Regents Of The University Of California |
Thermostable RNA-guided endonucleases and methods of use thereof
|
|
EP3633034A4
(en)
|
2017-05-31 |
2021-03-24 |
The University Of Tokyo |
MODIFIED Cas9 PROTEIN AND USE THEREOF
|
|
US20200140835A1
(en)
|
2017-06-06 |
2020-05-07 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 Nucleases
|
|
CN110997908A
(zh)
|
2017-06-09 |
2020-04-10 |
爱迪塔斯医药公司 |
工程化的cas9核酸酶
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
EP3650540B1
(en)
|
2017-07-07 |
2025-04-16 |
Toolgen Incorporated |
Target-specific crispr mutant
|
|
WO2019018041A1
(en)
|
2017-07-21 |
2019-01-24 |
Arizona Board Of Regents On Behalf Of Arizona State University |
MODULATION OF THE IMMUNE RESPONSE OF A HOST SPECIFIC TO HUMAN CAS9
|
|
AU2018318135B2
(en)
|
2017-08-15 |
2024-09-12 |
Intellia Therapeutics, Inc. |
Stabilized nucleic acids encoding messenger ribonucleic acid (mRNA)
|
|
EP3672612A4
(en)
|
2017-08-23 |
2021-09-29 |
The General Hospital Corporation |
GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES WITH MODIFIED PAM SPECIFICITY
|
|
EP3676378A4
(en)
|
2017-08-31 |
2021-06-09 |
The New York Genome Center |
PROCEDURES AND COMPOSITIONS USING CRIMP-CPF1 AND PAIRED GUIDE-CRISPR-RNA FOR PROGRAMMABLE GENOMIC DELETIONS
|
|
US11530396B2
(en)
|
2017-09-05 |
2022-12-20 |
The University Of Tokyo |
Modified CAS9 protein, and use thereof
|
|
US11713452B2
(en)
|
2017-09-08 |
2023-08-01 |
University Of North Texas Health Science Center |
Engineered CAS9 variants
|
|
US20190218532A1
(en)
|
2017-09-19 |
2019-07-18 |
Massachusetts Institute Of Technology |
Streptococcus Canis Cas9 as a Genome Engineering Platform with Novel PAM Specificity
|
|
CN111373041B
(zh)
|
2017-09-26 |
2024-10-11 |
伊利诺伊大学理事会 |
用于基因组编辑和调节转录的crispr/cas系统和方法
|
|
GB201716590D0
(en)
|
2017-10-10 |
2017-11-22 |
Univ Wageningen |
Thermostable cas9 nucleases with reduced off-target activity
|
|
WO2019083532A1
(en)
|
2017-10-26 |
2019-05-02 |
Excision Biotherapeutics Inc |
IDENTIFICATION OF GENE EDITION PROTEINS AND GENE EXCISION (TYPE CAS9 AND ARGONAUTE) FROM OTHER ORGANISMS
|
|
US20200339967A1
(en)
|
2017-11-01 |
2020-10-29 |
The Regents Of The University Of California |
Cas12c compositions and methods of use
|
|
BR112020008654A2
(pt)
|
2017-11-01 |
2020-11-10 |
The Regents Of The University Of California |
composições casz e métodos de uso
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
WO2019089808A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Class 2 crispr/cas compositions and methods of use
|
|
WO2019090174A1
(en)
|
2017-11-02 |
2019-05-09 |
Arbor Biotechnologies, Inc. |
Novel crispr-associated transposon systems and components
|
|
WO2019092507A2
(en)
|
2017-11-09 |
2019-05-16 |
Crispr Therapeutics Ag |
Crispr/cas systems for treatment of dmd
|
|
US20200318086A1
(en)
|
2017-11-10 |
2020-10-08 |
Novozymes A/S |
Temperature-sensitive cas9 protein
|
|
CN120310773A
(zh)
|
2017-11-16 |
2025-07-15 |
阿斯利康(瑞典)有限公司 |
用于改善基于Cas9的敲入策略的有效性的组合物和方法
|
|
US20200392473A1
(en)
|
2017-12-22 |
2020-12-17 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
EP3728588A4
(en)
|
2017-12-22 |
2022-03-09 |
The Broad Institute, Inc. |
CAS12A SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED EDIT OF RNA BASES
|
|
US20210071163A1
(en)
|
2017-12-22 |
2021-03-11 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted rna base editing
|
|
US20230193242A1
(en)
|
2017-12-22 |
2023-06-22 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted dna base editing
|
|
WO2019168953A1
(en)
|
2018-02-27 |
2019-09-06 |
President And Fellows Of Harvard College |
Evolved cas9 variants and uses thereof
|
|
EP4253551A3
(en)
|
2018-03-14 |
2024-01-24 |
Arbor Biotechnologies, Inc. |
Novel crispr dna and rna targeting enzymes and systems
|
|
ES2952978T3
(es)
|
2018-03-14 |
2023-11-07 |
Arbor Biotechnologies Inc |
Sistemas y enzimas novedosos de direccionamiento a ADN de CRISPR
|
|
CA3092497A1
(en)
|
2018-03-19 |
2019-09-26 |
Crispr Therapeutics Ag |
Novel rna-programmable endonuclease systems and uses thereof
|