JP2024138268A5 - - Google Patents
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- JP2024138268A5 JP2024138268A5 JP2024095566A JP2024095566A JP2024138268A5 JP 2024138268 A5 JP2024138268 A5 JP 2024138268A5 JP 2024095566 A JP2024095566 A JP 2024095566A JP 2024095566 A JP2024095566 A JP 2024095566A JP 2024138268 A5 JP2024138268 A5 JP 2024138268A5
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862670588P | 2018-05-11 | 2018-05-11 | |
| US62/670,588 | 2018-05-11 | ||
| US201862780838P | 2018-12-17 | 2018-12-17 | |
| US62/780,838 | 2018-12-17 | ||
| US201962817986P | 2019-03-13 | 2019-03-13 | |
| US62/817,986 | 2019-03-13 | ||
| PCT/US2019/031899 WO2019217944A1 (en) | 2018-05-11 | 2019-05-11 | Methods of editing single nucleotide polymorphism using programmable base editor systems |
| JP2021513765A JP7596259B2 (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513765A Division JP7596259B2 (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024138268A JP2024138268A (ja) | 2024-10-08 |
| JP2024138268A5 true JP2024138268A5 (enExample) | 2025-04-25 |
Family
ID=68466849
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513765A Active JP7596259B2 (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
| JP2021513764A Pending JP2021523738A (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
| JP2024095566A Pending JP2024138268A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
| JP2024095618A Pending JP2024147545A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513765A Active JP7596259B2 (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを用いて単一ヌクレオチド多型を編集する方法 |
| JP2021513764A Pending JP2021523738A (ja) | 2018-05-11 | 2019-05-11 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024095618A Pending JP2024147545A (ja) | 2018-05-11 | 2024-06-13 | プログラム可能な塩基エディターシステムを使用して単一ヌクレオチド多型を編集する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20210380955A1 (enExample) |
| EP (2) | EP3790595A4 (enExample) |
| JP (4) | JP7596259B2 (enExample) |
| KR (3) | KR20210023832A (enExample) |
| CN (3) | CN119587720A (enExample) |
| AU (2) | AU2019266326A1 (enExample) |
| CA (2) | CA3100037A1 (enExample) |
| WO (2) | WO2019217943A1 (enExample) |
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| CN118416088A (zh) | 2017-03-03 | 2024-08-02 | 加利福尼亚大学董事会 | 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向 |
| EP3633034A4 (en) | 2017-05-31 | 2021-03-24 | The University Of Tokyo | MODIFIED Cas9 PROTEIN AND USE THEREOF |
| WO2019040650A1 (en) | 2017-08-23 | 2019-02-28 | The General Hospital Corporation | GENETICALLY MODIFIED CRISPR-CAS9 NUCLEASES HAVING MODIFIED PAM SPECIFICITY |
| EP3720507A4 (en) * | 2017-12-07 | 2021-08-25 | Ramot at Tel-Aviv University Ltd. | TREATMENT OF PARKINSON PATIENTS WITH MUTATIONS IN THE LRRK2 GENE |
| CN112041444A (zh) | 2018-03-14 | 2020-12-04 | 阿伯生物技术公司 | 新型crispr dna靶向酶及系统 |
| JP7642531B2 (ja) | 2018-05-11 | 2025-03-10 | ビーム セラピューティクス インク． | プログラム可能塩基エディターシステムを用いて病原性アミノ酸を置換する方法 |
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| CN116497067B (zh) | 2019-02-13 | 2025-01-24 | 比姆医疗股份有限公司 | 治疗血红素病变的组合物和方法 |
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| WO2020236936A1 (en) * | 2019-05-21 | 2020-11-26 | Beam Therapeutics Inc. | Methods of editing a single nucleotide polymorphism using programmable base editor systems |
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| JP7500927B2 (ja) * | 2019-08-06 | 2024-06-18 | 日本製紙株式会社 | プロテイン用マスキング剤 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CA3159944A1 (en) | 2019-12-02 | 2021-06-10 | David HUSS | Therapeutic editing |
| US20230054569A1 (en) * | 2019-12-18 | 2023-02-23 | Alia Therapeutics Srl | Compositions and methods for treating retinitis pigmentosa |
| US12264341B2 (en) * | 2020-01-24 | 2025-04-01 | The General Hospital Corporation | CRISPR-Cas enzymes with enhanced on-target activity |
| US12312613B2 (en) | 2020-01-24 | 2025-05-27 | The General Hospital Corporation | Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants |
| WO2021155166A1 (en) * | 2020-01-31 | 2021-08-05 | University Of Massachusetts | A cas9-pdbd base editor platform with improved targeting range and specificity |
| WO2021163492A1 (en) * | 2020-02-14 | 2021-08-19 | Ohio State Innovation Foundation | Nucleobase editors and methods of use thereof |
| IT202000008014A1 (it) * | 2020-04-15 | 2021-10-15 | Fond Telethon | RNA guida e loro usi |
| US20230165909A1 (en) * | 2020-04-21 | 2023-06-01 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
| US20250263752A1 (en) * | 2020-04-21 | 2025-08-21 | Aspen Neuroscience, Inc. | Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom |
| US20230159913A1 (en) | 2020-04-28 | 2023-05-25 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
| WO2021226558A1 (en) | 2020-05-08 | 2021-11-11 | The Broad Institute, Inc. | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| WO2022015856A1 (en) * | 2020-07-14 | 2022-01-20 | The Regents Of The University Of California | Compositions and methods for treating an inherited retinal disease |
| WO2022020800A2 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| WO2022027035A1 (en) * | 2020-07-27 | 2022-02-03 | The Children's Hospital Of Philadelphia | In utero and postnatal gene editing and therapy for treatment of monogenic diseases, including mucopolysaccharidosis type 1h and other disorders |
| JP2023543803A (ja) * | 2020-09-24 | 2023-10-18 | ザ ブロード インスティテュート，インコーポレーテッド | プライム編集ガイドｒｎａ、その組成物、及びその使用方法 |
| CA3200521A1 (en) * | 2020-11-06 | 2022-05-12 | Pairwise Plants Services, Inc. | Compositions and methods for rna-encoded dna-replacement of alleles |
| AU2021396392A1 (en) * | 2020-12-10 | 2023-07-06 | Apellis Pharmaceuticals, Inc. | Genomic editing of complement |
| WO2022197727A1 (en) * | 2021-03-15 | 2022-09-22 | Duke University | Generation of novel crispr genome editing agents using combinatorial chemistry |
| WO2022241270A2 (en) * | 2021-05-14 | 2022-11-17 | Beam Therapeutics Inc. | Compositions and methods for treating transthyretin amyloidosis |
| WO2022246266A1 (en) * | 2021-05-21 | 2022-11-24 | Beam Therapeutics Inc. | Base editing of transthyretin gene |
| KR20240012377A (ko) * | 2021-05-28 | 2024-01-29 | 빔 테라퓨틱스, 인크. | 염기 편집기의 자기-불활성화용 조성물 및 방법 |
| WO2023064858A1 (en) * | 2021-10-13 | 2023-04-20 | Apellis Pharmaceuticals, Inc. | Compositions and methods for genome editing the neonatal fc receptor |
| JP2024544013A (ja) | 2021-12-03 | 2024-11-26 | ザ ブロード インスティテュート，インコーポレーテッド | 有効なｉｎ ｖｉｖｏ送達のための組成物および方法 |
| US20250154479A1 (en) * | 2022-01-24 | 2025-05-15 | Toolgen Incorporated | Streptococcus pyogenes-derived cas9 variant |
| CN114480445B (zh) * | 2022-01-26 | 2023-06-27 | 西南交通大学 | 一种人源超氧化物歧化酶hSOD1突变体的制备及其应用 |
| WO2023217280A1 (en) * | 2022-05-13 | 2023-11-16 | Huidagene Therapeutics Co., Ltd. | Programmable adenine base editor and uses thereof |
| CN120303407A (zh) | 2022-05-17 | 2025-07-11 | 恩维洛普治疗有限责任公司 | 用于有效体内递送的组合物和方法 |
| CN115148281B (zh) * | 2022-06-29 | 2023-07-14 | 广州源井生物科技有限公司 | 一种基因编辑点突变方案自动设计方法及系统 |
| CN120225674A (zh) * | 2022-09-08 | 2025-06-27 | 爱丁堡大学董事会 | 雷特综合征疗法 |
| WO2024107784A2 (en) * | 2022-11-15 | 2024-05-23 | Vanderbilt University | Repair of disease-associated single nucleotide variants via interallelic gene conversion |
| WO2024259364A2 (en) * | 2023-06-15 | 2024-12-19 | Beam Therapeutics Inc. | Methods and compositions for treating alpha-1 antitrypsin deficiency |
| WO2025024486A2 (en) * | 2023-07-25 | 2025-01-30 | Flagship Pioneering Innovations Vii, Llc | Cas endonucleases and related methods |
| US20250059567A1 (en) * | 2023-08-17 | 2025-02-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for the management and treatment of phenylketonuria |
| WO2025059520A1 (en) * | 2023-09-15 | 2025-03-20 | Beam Therapeutics Inc. | Compositions and methods for base editing a phenylalanine hydroxylase polynucleotide |
| WO2025061198A1 (zh) * | 2023-09-22 | 2025-03-27 | 北京大学现代农业研究院 | 改进的基因组编辑方法 |
| WO2025122725A1 (en) * | 2023-12-06 | 2025-06-12 | The Broad Institute, Inc. | Methods and compositions for base editing of tpp1 in the treatment of batten disease |
| CN118120704B (zh) * | 2024-01-30 | 2025-10-24 | 江苏集萃药康生物科技股份有限公司 | 一种免高脂饮食诱导的动脉粥样硬化小鼠模型的构建方法 |
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-
2019
- 2019-05-11 AU AU2019266326A patent/AU2019266326A1/en active Pending
- 2019-05-11 CA CA3100037A patent/CA3100037A1/en active Pending
- 2019-05-11 KR KR1020207035000A patent/KR20210023832A/ko active Pending
- 2019-05-11 WO PCT/US2019/031898 patent/WO2019217943A1/en not_active Ceased
- 2019-05-11 EP EP19799854.5A patent/EP3790595A4/en active Pending
- 2019-05-11 CN CN202411723844.9A patent/CN119587720A/zh active Pending
- 2019-05-11 WO PCT/US2019/031899 patent/WO2019217944A1/en not_active Ceased
- 2019-05-11 EP EP19799484.1A patent/EP3790963A4/en active Pending
- 2019-05-11 US US17/054,324 patent/US20210380955A1/en active Pending
- 2019-05-11 CA CA3100034A patent/CA3100034A1/en active Pending
- 2019-05-11 KR KR1020207035001A patent/KR102853088B1/ko active Active
- 2019-05-11 KR KR1020257028616A patent/KR20250133482A/ko active Pending
- 2019-05-11 AU AU2019266327A patent/AU2019266327B2/en active Active
- 2019-05-11 CN CN201980046479.3A patent/CN112469446B/zh active Active
- 2019-05-11 US US17/054,348 patent/US20230159956A1/en active Pending
- 2019-05-11 JP JP2021513765A patent/JP7596259B2/ja active Active
- 2019-05-11 JP JP2021513764A patent/JP2021523738A/ja active Pending
- 2019-05-11 CN CN201980046538.7A patent/CN112469824A/zh active Pending
-
2024
- 2024-06-13 JP JP2024095566A patent/JP2024138268A/ja active Pending
- 2024-06-13 JP JP2024095618A patent/JP2024147545A/ja active Pending
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