JP2017070307A5 - - Google Patents
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- Publication number
- JP2017070307A5 JP2017070307A5 JP2017002170A JP2017002170A JP2017070307A5 JP 2017070307 A5 JP2017070307 A5 JP 2017070307A5 JP 2017002170 A JP2017002170 A JP 2017002170A JP 2017002170 A JP2017002170 A JP 2017002170A JP 2017070307 A5 JP2017070307 A5 JP 2017070307A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid region
- region
- acid molecule
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010096520 | 2010-04-19 | ||
| JP2010096520 | 2010-04-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015165287A Division JP6311092B2 (ja) | 2010-04-19 | 2015-08-24 | 機能性核酸の安定化法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017070307A JP2017070307A (ja) | 2017-04-13 |
| JP2017070307A5 true JP2017070307A5 (enExample) | 2017-07-13 |
Family
ID=44834191
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511666A Active JP5892608B2 (ja) | 2010-04-19 | 2011-04-19 | 機能性核酸の安定化法 |
| JP2015165287A Active JP6311092B2 (ja) | 2010-04-19 | 2015-08-24 | 機能性核酸の安定化法 |
| JP2017002170A Pending JP2017070307A (ja) | 2010-04-19 | 2017-01-10 | 機能性核酸の安定化法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511666A Active JP5892608B2 (ja) | 2010-04-19 | 2011-04-19 | 機能性核酸の安定化法 |
| JP2015165287A Active JP6311092B2 (ja) | 2010-04-19 | 2015-08-24 | 機能性核酸の安定化法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP2562257A4 (enExample) |
| JP (3) | JP5892608B2 (enExample) |
| WO (1) | WO2011132672A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2562257A4 (en) * | 2010-04-19 | 2014-10-01 | Riken | PROCESS FOR STABILIZING FUNCTIONAL NUCLEIC ACIDS |
| US8785121B2 (en) | 2010-07-08 | 2014-07-22 | Bonac Corporation | Single-stranded nucleic acid molecule for controlling gene expression |
| US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| EP2770054A4 (en) * | 2011-10-19 | 2015-09-02 | Riken | ACTIVATION OF FUNCTIONAL NUCLEIC ACIDS BY SPECIFIC MODIFICATION |
| EP2774989B1 (en) * | 2011-11-02 | 2018-09-05 | Osaka City University | Double-stranded nucleic acid molecule for gene expression control |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| EP2857513A4 (en) | 2012-05-26 | 2016-05-25 | Bonac Corp | Single-stranded nucleic acid molecule controlling the expression of a gene transporter |
| US10612020B2 (en) | 2013-12-26 | 2020-04-07 | Tokyo Medical University | Artificial mimic miRNA for controlling gene expression, and use of same |
| CA2935022A1 (en) | 2013-12-27 | 2015-07-02 | Bonac Corporation | Artificial match-type mirna for controlling gene expression and use therefor |
| WO2016100401A1 (en) * | 2014-12-15 | 2016-06-23 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
| JP6471176B2 (ja) | 2014-12-27 | 2019-02-13 | 株式会社ボナック | 遺伝子発現制御のための天然型ｍｉＲＮＡおよびその用途 |
| US10550393B2 (en) | 2015-03-06 | 2020-02-04 | Tagcyx Biotechnologies | Method for stabilizing DNA aptamers |
| WO2016158809A1 (ja) | 2015-03-27 | 2016-10-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| CN108342386B (zh) * | 2017-01-22 | 2022-04-15 | 广州市锐博生物科技有限公司 | 一种多聚寡核酸分子及其在多靶标干扰中的应用 |
| WO2019161904A1 (en) | 2018-02-23 | 2019-08-29 | Kamel Wael Sayed Saleh Elsayed | Stable rna molecules |
| CN108646014B (zh) * | 2018-05-21 | 2020-07-17 | 青岛大学 | 基于适体构象变化的荧光检测血小板源性生长因子的方法 |
| SG11202106046XA (en) * | 2018-12-12 | 2021-07-29 | Dicerna Pharmaceuticals Inc | Double-stranded nucleic acid inhibitor molecules containing a triloop |
| WO2020226960A1 (en) * | 2019-05-03 | 2020-11-12 | Dicerna Pharmaceuticals, Inc. | Double-stranded nucleic acid inhibitor molecules with shortened sense strands |
| EP4081642A1 (en) * | 2020-03-16 | 2022-11-02 | Argonaute Rna Limited | Antagonist of pcsk9 |
| EP4143320A4 (en) * | 2020-04-30 | 2024-06-19 | Mpeg LA, L.l.c. | Multimeric oligonucleotides with divided strands |
| JP7743246B2 (ja) * | 2021-09-29 | 2025-09-24 | 栄研化学株式会社 | 標的ｒｎａ検出方法及びプローブキット |
| GB2618915B (en) * | 2022-05-18 | 2024-08-14 | Argonaute Rna Ltd | Treatment of cardiovascular disease |
| JP2024000312A (ja) * | 2022-06-20 | 2024-01-05 | Ｔｏｐｐａｎホールディングス株式会社 | 蛍光物質及び消光物質で標識された一本鎖オリゴヌクレオチド |
| EP4680740A1 (en) * | 2023-03-14 | 2026-01-21 | Argonaute Rna Limited | Conjugate comprising a double stranded rna molecule linked to a single stranded dna molecule |
| WO2025096807A2 (en) * | 2023-10-31 | 2025-05-08 | Flagship Pioneering Innovations Vii, Llc | Novel therapeutic dna forms |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014843A1 (en) * | 1991-02-21 | 1992-09-03 | Gilead Sciences, Inc. | Aptamer specific for biomolecules and method of making |
| US20030040613A1 (en) | 2000-04-24 | 2003-02-27 | Bishop Karl Duncan | Structurally modified molecular decoys for the manipulation of cellular or viral replication and other uses relating thereto |
| AU2002255285B2 (en) * | 2002-04-26 | 2008-03-06 | Anges Mg, Inc. | Circular dumbbell decoy oligodeoxynucleotides (CDODN) containing DNA bindings sites of transcription |
| PT3222724T (pt) * | 2002-08-05 | 2018-12-17 | Silence Therapeutics Gmbh | Formas adicionais novas de moléculas de rna de interferência |
| JP4517061B2 (ja) | 2003-08-08 | 2010-08-04 | 独立行政法人産業技術総合研究所 | ダンベル型ｄｎａの効率的な製造方法 |
| JP2008512097A (ja) * | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | アプタマー医薬品化学 |
| JPWO2006080262A1 (ja) * | 2005-01-27 | 2008-06-19 | 学校法人 久留米大学 | Ａｇｅ−２アプタマー |
| ATE546526T1 (de) * | 2005-05-25 | 2012-03-15 | Univ York | Hybrid-interferenz-rna |
| JP2010096520A (ja) | 2008-10-14 | 2010-04-30 | National Institute Of Advanced Industrial Science & Technology | スキャン画像取得装置およびシステム |
| EP2562257A4 (en) * | 2010-04-19 | 2014-10-01 | Riken | PROCESS FOR STABILIZING FUNCTIONAL NUCLEIC ACIDS |
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2011
- 2011-04-19 EP EP11772007.8A patent/EP2562257A4/en not_active Ceased
- 2011-04-19 WO PCT/JP2011/059619 patent/WO2011132672A1/ja not_active Ceased
- 2011-04-19 JP JP2012511666A patent/JP5892608B2/ja active Active
- 2011-04-19 EP EP18158543.1A patent/EP3358014B1/en active Active
-
2015
- 2015-08-24 JP JP2015165287A patent/JP6311092B2/ja active Active
-
2017
- 2017-01-10 JP JP2017002170A patent/JP2017070307A/ja active Pending