|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
US8796436B2
(en)
*
|
2003-04-17 |
2014-08-05 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
|
US7723509B2
(en)
|
2003-04-17 |
2010-05-25 |
Alnylam Pharmaceuticals |
IRNA agents with biocleavable tethers
|
|
AU2009322290B2
(en)
|
2008-12-03 |
2016-06-16 |
Arcturus Therapeutics, Inc. |
Una oligomer structures for therapeutic agents
|
|
US20150025122A1
(en)
|
2009-10-12 |
2015-01-22 |
Larry J. Smith |
Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
|
|
WO2011109427A2
(en)
|
2010-03-01 |
2011-09-09 |
Alnylam Pharmaceuticals, Inc. |
Improving the biological activity of sirna through modulation of its thermodynamic profile
|
|
WO2012007477A1
(en)
|
2010-07-12 |
2012-01-19 |
Santaris Pharma A/S |
Anti hcv oligomers
|
|
US10501513B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
|
WO2013151665A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
AU2013266236A1
(en)
*
|
2012-05-23 |
2014-12-18 |
The Ohio State University |
Lipid nanoparticle compositions and methods of making and methods of using the same
|
|
WO2013179292A1
(en)
*
|
2012-05-31 |
2013-12-05 |
Qbi Enterprises Ltd. |
Therapeutic oligonucleotides comprising pyrazolotriazine nucleotide analogues
|
|
WO2014066142A1
(en)
*
|
2012-10-24 |
2014-05-01 |
Novamedica Limited Liability Company |
Nucleic acid regulation of growth arrest-specific protein 6 (gas6)
|
|
JP2016515381A
(ja)
*
|
2013-03-15 |
2016-05-30 |
テチュロン インコーポレイテッド |
黄色ブドウ球菌感染の治療のためのアンチセンス分子
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
AU2015364508A1
(en)
|
2014-12-18 |
2017-07-06 |
Alnylam Pharmaceuticals, Inc. |
ReversirTM compounds
|
|
US10264976B2
(en)
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
|
US11045488B2
(en)
|
2014-12-26 |
2021-06-29 |
Nitto Denko Corporation |
RNA interference agents for GST-π gene modulation
|
|
EP3929293A3
(en)
|
2015-04-03 |
2022-03-16 |
University Of Massachusetts |
Fully stabilized asymmetric sirna
|
|
JP2018520683A
(ja)
|
2015-07-17 |
2018-08-02 |
アルニラム ファーマスーティカルズ インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
多標的単一体コンジュゲート
|
|
WO2017030973A1
(en)
|
2015-08-14 |
2017-02-23 |
University Of Massachusetts |
Bioactive conjugates for oligonucleotide delivery
|
|
JP6988481B2
(ja)
|
2016-01-26 |
2022-01-05 |
日産化学株式会社 |
一本鎖オリゴヌクレオチド
|
|
HK1258758A1
(zh)
|
2016-01-31 |
2019-11-22 |
University Of Massachusetts |
分支的寡核苷酸
|
|
US11208653B2
(en)
|
2016-04-27 |
2021-12-28 |
Whitehead Institute For Biomedical Research |
Increasing RNAi efficiency through single nucleotide mismatches
|
|
EP3496758A4
(en)
|
2016-08-12 |
2020-11-11 |
University of Massachusetts |
CONJUGATE OLIGONUCLEOTIDES
|
|
TW202313978A
(zh)
|
2016-11-23 |
2023-04-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
|
CA3052801A1
(en)
*
|
2017-02-06 |
2018-08-09 |
Nissan Chemical Corporation |
Single-stranded oligonucleotide
|
|
JP7406793B2
(ja)
|
2017-06-23 |
2023-12-28 |
ユニバーシティー オブ マサチューセッツ |
2テイル自己デリバリー型siRNAおよび関連方法
|
|
WO2019217459A1
(en)
|
2018-05-07 |
2019-11-14 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
|
WO2020041769A1
(en)
*
|
2018-08-23 |
2020-02-27 |
University Of Massachusetts |
O-methyl rich fully stabilized oligonucleotides
|
|
WO2020069055A1
(en)
|
2018-09-28 |
2020-04-02 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
|
CN113614232A
(zh)
|
2019-01-18 |
2021-11-05 |
马萨诸塞大学 |
动态药代动力学修饰锚
|
|
AU2020279101B2
(en)
|
2019-05-17 |
2025-07-24 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
|
US20230049529A1
(en)
*
|
2019-06-21 |
2023-02-16 |
Alnylam Pharmaceuticals, Inc. |
Modified double stranded oligonucleotide
|
|
US12024706B2
(en)
|
2019-08-09 |
2024-07-02 |
University Of Massachusetts |
Modified oligonucleotides targeting SNPs
|
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
US12365894B2
(en)
|
2019-09-16 |
2025-07-22 |
University Of Massachusetts |
Branched lipid conjugates of siRNA for specific tissue delivery
|
|
WO2021067747A1
(en)
|
2019-10-04 |
2021-04-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
|
US20230040920A1
(en)
|
2019-11-01 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
|
JP2023500661A
(ja)
|
2019-11-01 |
2023-01-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ハンチンチン(HTT)iRNA剤組成物およびその使用方法
|
|
EP4055165A1
(en)
|
2019-11-06 |
2022-09-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
|
BR112022007795A2
(pt)
|
2019-11-06 |
2022-07-05 |
Alnylam Pharmaceuticals Inc |
Administração extra-hepática
|
|
WO2021102373A1
(en)
|
2019-11-22 |
2021-05-27 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
|
EP4073251A1
(en)
|
2019-12-13 |
2022-10-19 |
Alnylam Pharmaceuticals, Inc. |
Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
|
|
TW202140786A
(zh)
|
2020-02-10 |
2021-11-01 |
美商艾爾妮蘭製藥公司 |
用於靜默vegf-a表現之組合物及方法
|
|
EP4114947A1
(en)
|
2020-03-05 |
2023-01-11 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
|
JP2023519274A
(ja)
|
2020-03-26 |
2023-05-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
コロナウイルスiRNA組成物およびその使用方法
|
|
WO2021202443A2
(en)
|
2020-03-30 |
2021-10-07 |
Alnylam Pharmaceucticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
|
US12534731B2
(en)
|
2020-04-01 |
2026-01-27 |
Alnylam Pharmaceuticals, Inc. |
Alpha-2A adrenergic receptor (ADRA2A) iRNA agent compositions and methods of use thereof
|
|
JP2023520582A
(ja)
|
2020-04-06 |
2023-05-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Myoc発現をサイレンシングするための組成物および方法
|
|
AU2021251754A1
(en)
|
2020-04-07 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing SCN9A expression
|
|
EP4133077A1
(en)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
CN115955972A
(zh)
|
2020-04-27 |
2023-04-11 |
阿尔尼拉姆医药品有限公司 |
载脂蛋白E(APOE)iRNA剂组合物及其使用方法
|
|
US20230183707A1
(en)
|
2020-05-21 |
2023-06-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
|
WO2021242883A1
(en)
|
2020-05-26 |
2021-12-02 |
University Of Massachusetts |
Synthetic oligonucleotides having regions of block and cluster modifications
|
|
WO2021252557A1
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
|
KR102361479B1
(ko)
*
|
2020-06-18 |
2022-02-11 |
고려대학교 산학협력단 |
siRNA의 생성 및 기능 증진 활성을 갖는 CMTR1의 신규용도
|
|
WO2022011214A1
(en)
|
2020-07-10 |
2022-01-13 |
Alnylam Pharmaceuticals, Inc. |
Circular sirnas
|
|
EP4217489A1
(en)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
|
EP4225917A1
(en)
|
2020-10-05 |
2023-08-16 |
Alnylam Pharmaceuticals, Inc. |
G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
|
|
EP4232582A1
(en)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
|
JP2024501857A
(ja)
|
2020-12-31 |
2024-01-16 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
環状ジスルフィド修飾リン酸ベースのオリゴヌクレオチドプロドラッグ
|
|
EP4271695A2
(en)
|
2020-12-31 |
2023-11-08 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
|
CA3210763A1
(en)
|
2021-02-12 |
2022-08-18 |
Alnylam Pharmaceuticals, Inc. |
Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
|
|
CN117222739A
(zh)
|
2021-02-25 |
2023-12-12 |
阿尔尼拉姆医药品有限公司 |
朊病毒蛋白(prnp)irna组合物和其使用方法
|
|
CN114958839A
(zh)
*
|
2021-02-25 |
2022-08-30 |
上海市东方医院(同济大学附属东方医院) |
抑制肌肉瘤细胞中FOXO1基因表达的siRNA序列及应用
|
|
EP4305169A1
(en)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
|
BR112023019981A2
(pt)
|
2021-03-29 |
2023-12-12 |
Alnylam Pharmaceuticals Inc |
Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas
|
|
CN113304274B
(zh)
*
|
2021-04-23 |
2025-03-04 |
天津全和诚生物技术有限公司 |
缀合物及其制备方法和用途
|
|
WO2022245583A1
(en)
|
2021-05-18 |
2022-11-24 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
|
IL308743A
(en)
|
2021-06-04 |
2024-01-01 |
Alnylam Pharmaceuticals Inc |
Compositions of human chromosome 9 open reading frame 72 iRNA factor (C9ORF72) and methods of using them
|
|
US11702659B2
(en)
|
2021-06-23 |
2023-07-18 |
University Of Massachusetts |
Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
|
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
|
EP4373506A1
(en)
|
2021-07-20 |
2024-05-29 |
AGS Therapeutics SAS |
Extracellular vesicles from microalgae, their preparation, and uses
|
|
IL309897A
(en)
|
2021-07-21 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
Target gene IRNA compositions associated with a metabolic disorder and methods of using them
|
|
WO2023034837A2
(en)
|
2021-08-31 |
2023-03-09 |
Alnylam Pharmaceuticals, Inc. |
Cell death-inducing dffa-like effector b (cideb) irna compositions and methods of use thereof
|
|
KR20240067943A
(ko)
|
2021-09-24 |
2024-05-17 |
알닐람 파마슈티칼스 인코포레이티드 |
미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법
|
|
JP2024539629A
(ja)
|
2021-10-15 |
2024-10-29 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
肝外デリバリーiRNA組成物およびその使用方法
|
|
EP4423272A2
(en)
|
2021-10-29 |
2024-09-04 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
|
EP4469575A2
(en)
|
2022-01-24 |
2024-12-04 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
|
WO2023144127A1
(en)
|
2022-01-31 |
2023-08-03 |
Ags Therapeutics Sas |
Extracellular vesicles from microalgae, their biodistribution upon administration, and uses
|
|
CN119213005A
(zh)
|
2022-03-16 |
2024-12-27 |
艾姆皮瑞克公司 |
用于提高siRNA生物利用度的GALNAC组合物
|
|
KR20240163743A
(ko)
|
2022-03-28 |
2024-11-19 |
엠피리코 인크. |
변형된 올리고뉴클레오티드
|
|
EP4522742A2
(en)
|
2022-05-13 |
2025-03-19 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
|
WO2023232976A1
(en)
|
2022-06-03 |
2023-12-07 |
Ags Therapeutics Sas |
Extracellular vesicles from genetically-modified microalgae containing endogenously-loaded cargo, their preparation, and uses
|
|
EP4547683A2
(en)
|
2022-06-30 |
2025-05-07 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
|
CN121038801A
(zh)
|
2022-10-24 |
2025-11-28 |
Ags治疗简易股份公司 |
来自微藻的细胞外囊泡、它们在鼻内施用时的生物分布及其用途
|
|
EP4683645A1
(en)
*
|
2023-03-23 |
2026-01-28 |
Atalanta Therapeutics, Inc. |
Compositions and methods for improved gene silencing
|
|
WO2024216155A1
(en)
|
2023-04-12 |
2024-10-17 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery of double-stranded rna agents
|
|
WO2024238385A2
(en)
|
2023-05-12 |
2024-11-21 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
|
WO2025064660A2
(en)
|
2023-09-21 |
2025-03-27 |
Alnylam Pharmaceuticals, Inc. |
Activin a receptor type 1c (acvr1c) irna compositions and methods of use thereof
|
|
WO2025176843A1
(en)
|
2024-02-21 |
2025-08-28 |
Ags Therapeutics Sas |
Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof
|
|
WO2025259747A2
(en)
|
2024-06-12 |
2025-12-18 |
Alnylam Pharmaceuticals, Inc. |
Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof
|