JP2011528910A - センス鎖中の一般塩基またはミスマッチを使用したｓｉＲＮＡサイレンシング活性の亢進 - Google Patents

センス鎖中の一般塩基またはミスマッチを使用したｓｉＲＮＡサイレンシング活性の亢進 Download PDF

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JP2011528910A
JP2011528910A JP2011520219A JP2011520219A JP2011528910A JP 2011528910 A JP2011528910 A JP 2011528910A JP 2011520219 A JP2011520219 A JP 2011520219A JP 2011520219 A JP2011520219 A JP 2011520219A JP 2011528910 A JP2011528910 A JP 2011528910A
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sirna
irna agent
sense strand
gene
expression
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JP2011528910A5 (enExample
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マイアー，マーティン
アッデパリ，ハリプリヤ
マノハラン，ムシアー
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Alnylam Pharmaceuticals Inc
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JP2011520219A 2008-07-25 2009-07-24 センス鎖中の一般塩基またはミスマッチを使用したｓｉＲＮＡサイレンシング活性の亢進 Pending JP2011528910A (ja)

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US8376308P 2008-07-25 2008-07-25
US61/083,763 2008-07-25
PCT/US2009/051648 WO2010011895A1 (en) 2008-07-25 2009-07-24 Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand

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JP2011528910A5 JP2011528910A5 (enExample) 2012-11-29

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JP2016189465A Active JP6476155B2 (ja) 2008-07-25 2016-09-28 センス鎖中の一般塩基またはミスマッチを使用したｓｉＲＮＡサイレンシング活性の亢進

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Cited By (5)

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JP2015518704A (ja) * 2012-04-02 2015-07-06 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 膜タンパク質の産生のための修飾ポリヌクレオチド
WO2018143475A1 (ja) * 2017-02-06 2018-08-09 日産化学工業株式会社 一本鎖オリゴヌクレオチド
JP2022538404A (ja) * 2019-06-21 2022-09-02 アルナイラム ファーマシューティカルズ， インコーポレイテッド 構造的に明確なｓｉＲＮＡ－二重可変ドメイン免疫グロブリンコンジュゲート
US11530409B2 (en) 2016-01-26 2022-12-20 Nissan Chemical Corporation Single-stranded oligonucleotide
JP2024515734A (ja) * 2021-04-23 2024-04-10 南▲開▼大学 コンジュゲート、その製造方法、及び使用

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