MX2023002818A - Oligonucleotido de cadena simple. - Google Patents

Oligonucleotido de cadena simple.

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Publication number
MX2023002818A
MX2023002818A MX2023002818A MX2023002818A MX2023002818A MX 2023002818 A MX2023002818 A MX 2023002818A MX 2023002818 A MX2023002818 A MX 2023002818A MX 2023002818 A MX2023002818 A MX 2023002818A MX 2023002818 A MX2023002818 A MX 2023002818A
Authority
MX
Mexico
Prior art keywords
nucleotide sequence
hybridize
oligonucleotide
stranded oligonucleotide
nucleotides
Prior art date
Application number
MX2023002818A
Other languages
English (en)
Inventor
Hiroyuki Nakajima
Yusuke Iriyama
Tatsuro Kanaki
Original Assignee
Nissan Chemical Corp
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59398721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2023002818(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Publication of MX2023002818A publication Critical patent/MX2023002818A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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Abstract

Se proporciona un oligonucleótido de cadena simple que es capaz de controlar un gen objetivo con alta eficiencia y puede producirse fácilmente; el oligonucleótido de cadena simple es representado por la fórmula X-L-Y en donde X y Y se hibridan mediante una primera porción de la secuencia de nucleótidos y una segunda porción de la secuencia de nucleótidos; X está compuesta de 7 a 100 nucleótidos, contiene por lo menos un nucleótido modificado, y tiene una primera secuencia de nucleótidos que es capaz de hibridarse con un segundo oligonucleótido y contiene por lo menos cuatro nucleótidos contiguos reconocidos por RNasa H; Y está compuesta de 4 a 100 nucleótidos, y tiene una segunda secuencia de nucleótidos que es capaz de hibridarse con un segundo oligonucleótido y contiene por lo menos un ribonucleótido; por lo menos una de la secuencia de nucleótidos X y la secuencia de nucleótidos Y tiene una secuencia antisentido capaz de hibridarse con un ARN objetivo; L es un grupo derivado de un tercer oligonucleótido que se degrada bajo condiciones fisiológicas.
MX2023002818A 2016-01-26 2018-07-25 Oligonucleotido de cadena simple. MX2023002818A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016012804 2016-01-26
JP2016158833 2016-08-12

Publications (1)

Publication Number Publication Date
MX2023002818A true MX2023002818A (es) 2023-03-17

Family

ID=59398721

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018009090A MX2018009090A (es) 2016-01-26 2017-01-26 Oligonucleótido de cadena simple.
MX2023002818A MX2023002818A (es) 2016-01-26 2018-07-25 Oligonucleotido de cadena simple.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018009090A MX2018009090A (es) 2016-01-26 2017-01-26 Oligonucleótido de cadena simple.

Country Status (10)

Country Link
US (2) US11530409B2 (es)
EP (1) EP3409779A4 (es)
JP (3) JP6988481B2 (es)
CN (2) CN116064544A (es)
AU (1) AU2017211461B2 (es)
BR (1) BR112018015164A2 (es)
CA (1) CA3023222A1 (es)
MX (2) MX2018009090A (es)
TW (2) TWI803455B (es)
WO (1) WO2017131124A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116064544A (zh) 2016-01-26 2023-05-05 日产化学株式会社 单链寡核苷酸
CA3052801A1 (en) * 2017-02-06 2018-08-09 Nissan Chemical Corporation Single-stranded oligonucleotide
US11555188B2 (en) 2017-07-26 2023-01-17 Nissan Chemical Corporation Single-stranded oligonucleotide
AU2019237599A1 (en) 2018-03-20 2020-11-12 Nissan Chemical Corporation Antisense oligonucleotide having reduced toxicity
US20220162607A1 (en) 2019-03-14 2022-05-26 Rena Therapeutics Inc. Nucleic acid complex for modulating ihh expression
EP4098747A1 (en) 2020-01-31 2022-12-07 Sanwa Kagaku Kenkyusho Co., Ltd. Antisense oligonucleotide of atn1
EP4116419A1 (en) 2020-03-04 2023-01-11 Nissan Chemical Corporation Antisense oligonucleotide of calm2
JPWO2022211129A1 (es) * 2021-04-01 2022-10-06
EP4353266A1 (en) 2021-05-31 2024-04-17 Rena Therapeutics Inc. Ligand-bound nucleic acid complex

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08154687A (ja) 1994-12-12 1996-06-18 Yamanouchi Pharmaceut Co Ltd アンチセンスオリゴヌクレオチド及び抗ウイルス剤
JPH09110894A (ja) 1995-10-17 1997-04-28 Soyaku Gijutsu Kenkyusho:Kk ハイブリッドｄｎａ／ｒｎａオリゴヌクレオチド及び抗ウイルス剤
US20040171028A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Phosphorous-linked oligomeric compounds and their use in gene modulation
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
JPH11137260A (ja) 1997-11-06 1999-05-25 Soyaku Gijutsu Kenkyusho:Kk 抗インフルエンザウイルス環状ダンベル型ｒｎａ−ｄｎａキメラ化合物及び抗インフルエンザウイルス剤
AU6055299A (en) 1998-09-21 2000-04-10 Ribozyme Pharmaceuticals, Inc. Hairpin hybridizer molecules for modulation of gene expression
AU2395900A (en) * 1998-12-31 2000-07-31 Gene Logic, Inc. Assay device comprising mixed probes
MXPA01011708A (es) * 1999-06-25 2003-09-10 Insight Strategy & Marketing Polinucleotidos que codifican polipeptidos distantemente homologos a heparanasa.
EP1627061B1 (en) * 2001-05-18 2009-08-12 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
US20070032441A1 (en) * 2001-05-18 2007-02-08 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
EP2221377B2 (en) * 2002-02-01 2017-05-17 Life Technologies Corporation Oligonucleotide compositions with enhanced efficiency
WO2003068795A1 (fr) 2002-02-13 2003-08-21 Takeshi Imanishi Analogues de nucleoside et derive d'oligonucleotide comprenant un analogue nucleotidique de ces composes
AU2003213203A1 (en) 2002-02-20 2003-09-09 Ribozyme Pharmaceuticals, Incorporated Rna interference mediated inhibition of myc and myb genes or genes of their respective pathways
GB0205455D0 (en) * 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
EP2258847B2 (en) 2002-08-05 2020-07-01 Silence Therapeutics GmbH Futher novel forms of interfering RNA molecules
US20040058886A1 (en) 2002-08-08 2004-03-25 Dharmacon, Inc. Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
AU2003291721A1 (en) * 2002-11-05 2004-06-03 Isis Pharmaceuticals, Inc. Phosphorous-linked oligomeric compounds and their use in gene modulation
AU2003299864A1 (en) 2002-12-27 2004-07-29 P. Radhakrishnan Sirna compounds and methods for the downregulation of gene expression
JP4948163B2 (ja) * 2003-05-23 2012-06-06 サーナ・セラピューティクス・インコーポレイテッド 化学修飾した低分子干渉核酸（ｓｉＮＡ）を使用する遺伝子発現のＲＮＡ干渉仲介抑制
CA2528597C (en) 2003-06-11 2014-08-05 Hybridon, Inc. Stabilized immunomodulatory oligonucleotides
DK1661905T3 (da) 2003-08-28 2012-07-23 Takeshi Imanishi Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype
CN101155918A (zh) * 2005-02-01 2008-04-02 爱尔康公司 RNAi介导的高眼压靶标的抑制
EP2052079A2 (en) * 2006-07-17 2009-04-29 Sirna Therapeutics Inc. Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina)
CN101301478A (zh) * 2007-05-10 2008-11-12 贝勒医学院 以低氧诱导因子1-α(HIF1α)作为靶标的G-四合体寡核苷酸
EP2321414B1 (en) * 2008-07-25 2018-01-10 Alnylam Pharmaceuticals, Inc. Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand
EP2454371B1 (en) 2009-07-13 2021-01-20 Somagenics, Inc. Chemical modification of small hairpin rnas for inhibition of gene expression
WO2011052436A1 (ja) 2009-10-29 2011-05-05 国立大学法人大阪大学 架橋型人工ヌクレオシドおよびヌクレオチド
MX2012010479A (es) * 2010-03-08 2012-10-09 Monsanto Technology Llc Moleculas polinucleotidicas para regulacion genetica en plantas.
DK2558578T3 (en) 2010-04-13 2016-01-25 Life Technologies Corp CONFIGURATIONS AND METHODS FOR INHIBITION OF nucleic acid function
WO2011156202A1 (en) 2010-06-08 2011-12-15 Isis Pharmaceuticals, Inc. Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
US8785121B2 (en) 2010-07-08 2014-07-22 Bonac Corporation Single-stranded nucleic acid molecule for controlling gene expression
KR101894701B1 (ko) 2010-08-03 2018-09-04 가부시키가이샤 보낙 함질소 지환식 골격을 갖는 일본쇄 핵산 분자
WO2013040429A1 (en) * 2011-09-14 2013-03-21 Rana Therapeutics Inc. Multimeric oligonucleotide compounds
CA3106312A1 (en) 2011-12-16 2013-06-20 National University Corporation Tokyo Medical And Dental University Chimeric double-stranded nucleic acid
US9528111B2 (en) 2012-01-07 2016-12-27 Bonac Corporation Single-stranded nucleic acid molecule having amino acid backbone
US20150247141A1 (en) 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
CN103114131B (zh) * 2012-11-30 2018-10-02 珠海市坤元农业科技有限公司 一种引物中部序列干扰pcr技术
CN103333890B (zh) * 2012-12-21 2015-04-15 厦门成坤生物技术有限公司 治疗乙型病毒性肝炎的rna干扰制剂
IL284593B2 (en) 2013-05-01 2023-02-01 Ionis Pharmaceuticals Inc Compositions and methods for modulation of hbv and ttr expression
US11028387B2 (en) 2013-05-30 2021-06-08 National University Corporation Tokyo Medical And Dental University Double-stranded agents for delivering therapeutic oligonucleotides
CN104419702A (zh) * 2013-09-04 2015-03-18 北京中康万达医药科技有限公司 一种基于生物信息学筛选siRNA的方法
CN106068324B (zh) 2013-12-27 2020-12-29 株式会社博纳克 控制基因表达的人工匹配型miRNA及其用途
WO2015105083A1 (ja) 2014-01-07 2015-07-16 塩野義製薬株式会社 アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド
WO2015113922A1 (en) * 2014-01-30 2015-08-06 Roche Innovation Center Copenhagen A/S Poly oligomer compound with biocleavable conjugates
JPWO2016152352A1 (ja) * 2015-03-20 2018-01-11 国立大学法人名古屋大学 メラノーマ特異的バイオマーカー及びその利用
CN116064544A (zh) * 2016-01-26 2023-05-05 日产化学株式会社 单链寡核苷酸
US11878060B2 (en) * 2016-08-07 2024-01-23 Novartis Ag mRNA-mediated immunization methods
CA3052801A1 (en) * 2017-02-06 2018-08-09 Nissan Chemical Corporation Single-stranded oligonucleotide
US11555188B2 (en) * 2017-07-26 2023-01-17 Nissan Chemical Corporation Single-stranded oligonucleotide
AU2019237599A1 (en) * 2018-03-20 2020-11-12 Nissan Chemical Corporation Antisense oligonucleotide having reduced toxicity
EP3650559B1 (en) * 2018-11-08 2022-06-29 Siemens Healthcare GmbH Direct rna nanopore sequencing with help of a stem-loop polynucleotide
WO2020154344A1 (en) * 2019-01-22 2020-07-30 Korro Bio, Inc. Rna-editing oligonucleotides and uses thereof
EP4116419A1 (en) * 2020-03-04 2023-01-11 Nissan Chemical Corporation Antisense oligonucleotide of calm2

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