MX2016000019A - (arnip) gen especifico relacionado con las enfermedades respiratorias, (arnip) que contiene la estructura arn oligo helicoidal, composicion que contiene la misma para prevencion o tratamiento de las enfermedades respiratorias. - Google Patents

(arnip) gen especifico relacionado con las enfermedades respiratorias, (arnip) que contiene la estructura arn oligo helicoidal, composicion que contiene la misma para prevencion o tratamiento de las enfermedades respiratorias.

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Publication number
MX2016000019A
MX2016000019A MX2016000019A MX2016000019A MX2016000019A MX 2016000019 A MX2016000019 A MX 2016000019A MX 2016000019 A MX2016000019 A MX 2016000019A MX 2016000019 A MX2016000019 A MX 2016000019A MX 2016000019 A MX2016000019 A MX 2016000019A
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MX
Mexico
Prior art keywords
double
sirna
oligo rna
rna structure
respiratory disease
Prior art date
Application number
MX2016000019A
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English (en)
Inventor
CHAE Jeiwook
Oh Park Han
Oh Yoon Pyoung
Han Boram
Na KIM Mi
Original Assignee
Bioneer Corp
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Publication date
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of MX2016000019A publication Critical patent/MX2016000019A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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Abstract

La presente invención se refiere a un ARNip específico de genes relacionado con enfermedades respiratorias, en particular, a un ARNip específico de genes relaconado con fibrisis pulmonar idopática y enfermedad pulmonar obstructiva crónica (EPOC), y una estructura de oligo ARN bicatenario altamente eficiente que contiene el mismo, caracterizado porque la estructura de oligo ARN bicatenario tiene una estructura en la que los materiales hidrofícos e hidrofóbicos están unidos en ambos extremos del ARN bicatenario (ARNip) utilizando un enlace covalente simple o un enlace covalente mediado por enlazador para transferir eficazmente en una célula, y se pueden convertir en nanopartículas por la interacción hidrofóbica de la estructura de oligo ARN bicatenario de en una solución. Es deseable que el ARNip contenido en la estructura de oliogo ARN bicatenario es un ARNip especifico para CTGF,Cyr61, Plekho1, que son genes relacionados con enfermedades respiratorias, particularmente de fibrosis pulmonar idopática y la EPOC. Además, la presente invención se refiere a un método para producir la estructura bicatenario de oligo ARN y una composición farmaceútica que contiene la estructura del okigo ARN bicatenario para la prevención o el tratamiento de enfermedades respiratorias, particularmente la fibrosis pulmonar idopática y la EPOC.
MX2016000019A 2013-07-05 2014-07-04 (arnip) gen especifico relacionado con las enfermedades respiratorias, (arnip) que contiene la estructura arn oligo helicoidal, composicion que contiene la misma para prevencion o tratamiento de las enfermedades respiratorias. MX2016000019A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20130079311 2013-07-05
PCT/KR2014/006033 WO2015002513A2 (ko) 2013-07-05 2014-07-04 호흡기 질환 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 호흡기 질환 예방 또는 치료용 조성물

Publications (1)

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MX2016000019A true MX2016000019A (es) 2016-08-18

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MX2016000019A MX2016000019A (es) 2013-07-05 2014-07-04 (arnip) gen especifico relacionado con las enfermedades respiratorias, (arnip) que contiene la estructura arn oligo helicoidal, composicion que contiene la misma para prevencion o tratamiento de las enfermedades respiratorias.

Country Status (10)

Country Link
US (1) US20160122764A1 (es)
EP (2) EP3591053A1 (es)
JP (3) JP2016525346A (es)
KR (1) KR101867414B1 (es)
CN (3) CN110592083A (es)
AU (1) AU2014284836B2 (es)
CA (1) CA2917320C (es)
MX (1) MX2016000019A (es)
RU (1) RU2656154C2 (es)
WO (1) WO2015002513A2 (es)

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KR101567576B1 (ko) 2012-05-22 2015-11-10 올릭스 주식회사 세포 내 관통능을 가지고 ｒｎａ 간섭을 유도하는 핵산 분자 및 그 용도
CN108699556B (zh) 2015-11-16 2023-02-17 奥利克斯医药有限公司 使用靶向myd88或tlr3的rna复合物治疗老年性黄斑变性
WO2017134525A1 (en) 2016-02-02 2017-08-10 Olix Pharmaceuticals, Inc. TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGET lL4Rα, TRPA1, OR F2RL1
CN108779464B (zh) 2016-02-02 2022-05-17 奥利克斯医药有限公司 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病
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KR101861738B1 (ko) * 2016-08-24 2018-05-29 (주)바이오니아 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체
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KR101993894B1 (ko) * 2018-05-21 2019-06-28 (주)바이오니아 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체
CN112512532A (zh) * 2018-07-31 2021-03-16 雷莫内克斯生物制药有限公司 用于抑制ctgf表达的组合物
CN109402127B (zh) * 2018-09-29 2021-12-10 复旦大学附属眼耳鼻喉科医院 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用
KR102473989B1 (ko) * 2018-11-28 2022-12-07 (주)바이오니아 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물
US20220088051A1 (en) * 2019-01-15 2022-03-24 Bioneer Corporation Double-stranded oligonucleotide targeting dkk1 gene, construct including same, and hair loss prevention or hair growth composition containing same
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