JP2015514778A5 - - Google Patents
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- Publication number
- JP2015514778A5 JP2015514778A5 JP2015507173A JP2015507173A JP2015514778A5 JP 2015514778 A5 JP2015514778 A5 JP 2015514778A5 JP 2015507173 A JP2015507173 A JP 2015507173A JP 2015507173 A JP2015507173 A JP 2015507173A JP 2015514778 A5 JP2015514778 A5 JP 2015514778A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- smad7
- antisense oligonucleotide
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101700026522 SMAD7 Proteins 0.000 claims description 28
- 102000049873 Smad7 Human genes 0.000 claims description 28
- 108091034117 Oligonucleotide Proteins 0.000 claims description 23
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 22
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 22
- 206010012601 diabetes mellitus Diseases 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 238000002054 transplantation Methods 0.000 claims description 4
- 210000004153 islets of langerhan Anatomy 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000004104 gestational diabetes Diseases 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 23
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 210000000056 organ Anatomy 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261625904P | 2012-04-18 | 2012-04-18 | |
| US61/625,904 | 2012-04-18 | ||
| PCT/US2013/037150 WO2013158868A1 (en) | 2012-04-18 | 2013-04-18 | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018104372A Division JP2018131468A (ja) | 2012-04-18 | 2018-05-31 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514778A JP2015514778A (ja) | 2015-05-21 |
| JP2015514778A5 true JP2015514778A5 (enExample) | 2016-06-09 |
| JP6348484B2 JP6348484B2 (ja) | 2018-06-27 |
Family
ID=48326412
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015507173A Expired - Fee Related JP6348484B2 (ja) | 2012-04-18 | 2013-04-18 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
| JP2018104372A Pending JP2018131468A (ja) | 2012-04-18 | 2018-05-31 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018104372A Pending JP2018131468A (ja) | 2012-04-18 | 2018-05-31 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10081809B2 (enExample) |
| EP (1) | EP2839004B1 (enExample) |
| JP (2) | JP6348484B2 (enExample) |
| KR (1) | KR20150003824A (enExample) |
| CN (2) | CN104487574B (enExample) |
| AU (1) | AU2013249191B2 (enExample) |
| CA (1) | CA2870547A1 (enExample) |
| DK (1) | DK2839004T3 (enExample) |
| ES (1) | ES2732252T3 (enExample) |
| IN (1) | IN2014DN08158A (enExample) |
| MX (1) | MX370149B (enExample) |
| NZ (1) | NZ630914A (enExample) |
| RU (1) | RU2667960C2 (enExample) |
| WO (1) | WO2013158868A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| RU2739302C2 (ru) | 2008-11-13 | 2020-12-22 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| EP2748611B1 (en) | 2011-09-15 | 2016-11-23 | Nogra Pharma Limited | Methods for monitoring responsiveness to anti-smad7 therapy |
| NZ630914A (en) | 2012-04-18 | 2017-01-27 | Nogra Pharma Ltd | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| ES2704092T3 (es) * | 2014-04-30 | 2019-03-14 | Procter & Gamble | Composición limpiadora |
| EP3140658A2 (en) | 2014-05-09 | 2017-03-15 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| EP3162878A1 (en) * | 2015-10-29 | 2017-05-03 | The Procter and Gamble Company | Liquid detergent composition |
| EP3165593B1 (en) * | 2015-10-29 | 2019-01-23 | The Procter and Gamble Company | Liquid detergent composition |
| JP2019505598A (ja) | 2016-02-23 | 2019-02-28 | セルジーン アルパイン インベストメント カンパニー Ｉｉ， エルエルシー | Ｓｍａｄ７の阻害を用いて、腸線維症を治療する方法 |
| CN112840025A (zh) * | 2018-05-08 | 2021-05-25 | 迈阿密大学 | 用于将治疗性核酸递送到组织的材料方法 |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| JP2023530109A (ja) | 2020-06-11 | 2023-07-13 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を予防するための方法および組成物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| AU2002363182A1 (en) | 2001-11-02 | 2003-05-12 | Ribopharma Ag | Smad7 inhibitors for the treatment of cns diseases |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| ES2761262T3 (es) * | 2003-06-13 | 2020-05-19 | Alnylam Europe Ag | Acido ribonucleico bicatenario con elevada eficacia en un organismo |
| ITRM20030393A1 (it) * | 2003-08-11 | 2005-02-12 | Giuliani Spa | Uso di oligonucleotidi (odn) antisenso per smad7 per il trattamento delle patologie mediate dal fattore di trascrizione nucleare nf-kb. |
| GB0326778D0 (en) * | 2003-11-18 | 2003-12-24 | Imp College Innovations Ltd | Biological materials and uses thereof |
| WO2006035434A2 (en) | 2004-09-28 | 2006-04-06 | Quark Biotech, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| RU2434942C2 (ru) * | 2004-09-28 | 2011-11-27 | Кварк Фармасьютикалс, Инк. | Олигорибонуклеотиды и способы их применения для лечения острой почечной недостаточности и других заболеваний |
| WO2007039151A1 (en) | 2005-09-28 | 2007-04-12 | Universität Zürich | Blockers of transforming growth factor beta and its receptors for the treatment of infectious diseases |
| PL2281042T3 (pl) | 2008-04-18 | 2016-01-29 | Baxter Int | Kompozycja na bazie mikrosfer do zapobiegania i/lub cofania nowego przypadku cukrzycy autoimmunologicznej |
| RU2739302C2 (ru) | 2008-11-13 | 2020-12-22 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| EP2748611B1 (en) | 2011-09-15 | 2016-11-23 | Nogra Pharma Limited | Methods for monitoring responsiveness to anti-smad7 therapy |
| NZ630914A (en) | 2012-04-18 | 2017-01-27 | Nogra Pharma Ltd | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| MX363746B (es) | 2013-03-15 | 2019-04-01 | Nogra Pharma Ltd | Oligonucleótidos antisentido de smad7 para el tratamiento de cáncer colorrectal. |
| EP3140658A2 (en) | 2014-05-09 | 2017-03-15 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| JP2017537973A (ja) | 2014-10-17 | 2017-12-21 | ノグラ ファーマ リミテッド | バイオマーカーレベルを使用してｓｍａｄ７アンチセンスオリゴヌクレオチドを投与するおよびモニタリングするための方法 |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| JP2018531936A (ja) | 2015-09-30 | 2018-11-01 | ノグラ ファーマ リミテッド | バイオマーカー発現に基づいてｓｍａｄ７アンチセンスオリゴヌクレオチドを使用する方法 |
| CA3014383A1 (en) | 2016-02-24 | 2017-08-31 | Nogra Pharma Limited | Methods of treating celiac disease using smad7 inhibition |
| EP3562943A1 (en) | 2016-12-30 | 2019-11-06 | Nogra Pharma Limited | Compositions of smad7 antisense oligonucleotide and methods of treating or preventing psoriasis |
-
2013
- 2013-04-18 NZ NZ630914A patent/NZ630914A/en not_active IP Right Cessation
- 2013-04-18 RU RU2014146170A patent/RU2667960C2/ru not_active IP Right Cessation
- 2013-04-18 CN CN201380020520.2A patent/CN104487574B/zh not_active Expired - Fee Related
- 2013-04-18 ES ES13721452T patent/ES2732252T3/es active Active
- 2013-04-18 US US14/394,999 patent/US10081809B2/en not_active Expired - Fee Related
- 2013-04-18 WO PCT/US2013/037150 patent/WO2013158868A1/en not_active Ceased
- 2013-04-18 EP EP13721452.4A patent/EP2839004B1/en active Active
- 2013-04-18 KR KR1020147032172A patent/KR20150003824A/ko not_active Abandoned
- 2013-04-18 CN CN201710440085.9A patent/CN107252492A/zh active Pending
- 2013-04-18 CA CA2870547A patent/CA2870547A1/en not_active Abandoned
- 2013-04-18 JP JP2015507173A patent/JP6348484B2/ja not_active Expired - Fee Related
- 2013-04-18 AU AU2013249191A patent/AU2013249191B2/en not_active Ceased
- 2013-04-18 MX MX2014012650A patent/MX370149B/es active IP Right Grant
- 2013-04-18 DK DK13721452.4T patent/DK2839004T3/da active
- 2013-04-18 IN IN8158DEN2014 patent/IN2014DN08158A/en unknown
-
2018
- 2018-05-31 JP JP2018104372A patent/JP2018131468A/ja active Pending
- 2018-08-10 US US16/100,906 patent/US10443056B2/en not_active Expired - Fee Related
-
2019
- 2019-09-04 US US16/559,974 patent/US20200239884A1/en not_active Abandoned
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