RU2667960C2 - Способы лечения диабета и/или улучшения выживания панкреатических островков после трансплантации - Google Patents
Способы лечения диабета и/или улучшения выживания панкреатических островков после трансплантации Download PDFInfo
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- RU2667960C2 RU2667960C2 RU2014146170A RU2014146170A RU2667960C2 RU 2667960 C2 RU2667960 C2 RU 2667960C2 RU 2014146170 A RU2014146170 A RU 2014146170A RU 2014146170 A RU2014146170 A RU 2014146170A RU 2667960 C2 RU2667960 C2 RU 2667960C2
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- seq
- smad7
- diabetes
- cells
- antisense oligonucleotide
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| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| RU2739302C2 (ru) | 2008-11-13 | 2020-12-22 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| EP2748611B1 (en) | 2011-09-15 | 2016-11-23 | Nogra Pharma Limited | Methods for monitoring responsiveness to anti-smad7 therapy |
| NZ630914A (en) | 2012-04-18 | 2017-01-27 | Nogra Pharma Ltd | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| ES2704092T3 (es) * | 2014-04-30 | 2019-03-14 | Procter & Gamble | Composición limpiadora |
| EP3140658A2 (en) | 2014-05-09 | 2017-03-15 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| EP3162878A1 (en) * | 2015-10-29 | 2017-05-03 | The Procter and Gamble Company | Liquid detergent composition |
| EP3165593B1 (en) * | 2015-10-29 | 2019-01-23 | The Procter and Gamble Company | Liquid detergent composition |
| JP2019505598A (ja) | 2016-02-23 | 2019-02-28 | セルジーン アルパイン インベストメント カンパニー Ｉｉ， エルエルシー | Ｓｍａｄ７の阻害を用いて、腸線維症を治療する方法 |
| CN112840025A (zh) * | 2018-05-08 | 2021-05-25 | 迈阿密大学 | 用于将治疗性核酸递送到组织的材料方法 |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| JP2023530109A (ja) | 2020-06-11 | 2023-07-13 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を予防するための方法および組成物 |
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| WO2003037368A2 (en) * | 2001-11-02 | 2003-05-08 | Klinikum Der Universität Regensburg | Smad7 inhibitors for the treatment of cns diseases |
| WO2009129544A1 (en) * | 2008-04-18 | 2009-10-22 | Baxter International Inc. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
| RU2434942C2 (ru) * | 2004-09-28 | 2011-11-27 | Кварк Фармасьютикалс, Инк. | Олигорибонуклеотиды и способы их применения для лечения острой почечной недостаточности и других заболеваний |
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| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| ES2761262T3 (es) * | 2003-06-13 | 2020-05-19 | Alnylam Europe Ag | Acido ribonucleico bicatenario con elevada eficacia en un organismo |
| ITRM20030393A1 (it) * | 2003-08-11 | 2005-02-12 | Giuliani Spa | Uso di oligonucleotidi (odn) antisenso per smad7 per il trattamento delle patologie mediate dal fattore di trascrizione nucleare nf-kb. |
| GB0326778D0 (en) * | 2003-11-18 | 2003-12-24 | Imp College Innovations Ltd | Biological materials and uses thereof |
| WO2006035434A2 (en) | 2004-09-28 | 2006-04-06 | Quark Biotech, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| WO2007039151A1 (en) | 2005-09-28 | 2007-04-12 | Universität Zürich | Blockers of transforming growth factor beta and its receptors for the treatment of infectious diseases |
| RU2739302C2 (ru) | 2008-11-13 | 2020-12-22 | Ногра Фарма Лимитед | Антисмысловые композиции и способы их получения и применения |
| EP2748611B1 (en) | 2011-09-15 | 2016-11-23 | Nogra Pharma Limited | Methods for monitoring responsiveness to anti-smad7 therapy |
| NZ630914A (en) | 2012-04-18 | 2017-01-27 | Nogra Pharma Ltd | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| MX363746B (es) | 2013-03-15 | 2019-04-01 | Nogra Pharma Ltd | Oligonucleótidos antisentido de smad7 para el tratamiento de cáncer colorrectal. |
| EP3140658A2 (en) | 2014-05-09 | 2017-03-15 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
| JP2017537973A (ja) | 2014-10-17 | 2017-12-21 | ノグラ ファーマ リミテッド | バイオマーカーレベルを使用してｓｍａｄ７アンチセンスオリゴヌクレオチドを投与するおよびモニタリングするための方法 |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| JP2018531936A (ja) | 2015-09-30 | 2018-11-01 | ノグラ ファーマ リミテッド | バイオマーカー発現に基づいてｓｍａｄ７アンチセンスオリゴヌクレオチドを使用する方法 |
| CA3014383A1 (en) | 2016-02-24 | 2017-08-31 | Nogra Pharma Limited | Methods of treating celiac disease using smad7 inhibition |
| EP3562943A1 (en) | 2016-12-30 | 2019-11-06 | Nogra Pharma Limited | Compositions of smad7 antisense oligonucleotide and methods of treating or preventing psoriasis |
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2013
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003037368A2 (en) * | 2001-11-02 | 2003-05-08 | Klinikum Der Universität Regensburg | Smad7 inhibitors for the treatment of cns diseases |
| RU2434942C2 (ru) * | 2004-09-28 | 2011-11-27 | Кварк Фармасьютикалс, Инк. | Олигорибонуклеотиды и способы их применения для лечения острой почечной недостаточности и других заболеваний |
| WO2009129544A1 (en) * | 2008-04-18 | 2009-10-22 | Baxter International Inc. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
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| MIZOBUCHI T., et al., Differential expression of Smad7 transcripts identifies the CD4+CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts.J Immunol. 2003 Aug 1;171(3):1140-7. SMART NG., et al., Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.PLoS Biol. 2006 Feb;4(2):e39. Epub 2006 Jan 31. * |
| SMART NG., et al., Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.PLoS Biol. 2006 Feb;4(2):e39. Epub 2006 Jan 31. * |
Also Published As
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| KR20150003824A (ko) | 2015-01-09 |
| CN104487574B (zh) | 2017-07-07 |
| HK1207117A1 (en) | 2016-01-22 |
| US20200239884A1 (en) | 2020-07-30 |
| US10081809B2 (en) | 2018-09-25 |
| RU2014146170A (ru) | 2016-06-10 |
| JP2015514778A (ja) | 2015-05-21 |
| JP6348484B2 (ja) | 2018-06-27 |
| DK2839004T3 (da) | 2019-07-01 |
| NZ630914A (en) | 2017-01-27 |
| WO2013158868A1 (en) | 2013-10-24 |
| CN104487574A (zh) | 2015-04-01 |
| CA2870547A1 (en) | 2013-10-24 |
| AU2013249191B2 (en) | 2019-01-03 |
| IN2014DN08158A (enExample) | 2015-05-01 |
| AU2013249191A1 (en) | 2014-10-09 |
| MX2014012650A (es) | 2015-04-08 |
| CN107252492A (zh) | 2017-10-17 |
| MX370149B (es) | 2019-12-03 |
| US20190136237A1 (en) | 2019-05-09 |
| JP2018131468A (ja) | 2018-08-23 |
| US20150315573A1 (en) | 2015-11-05 |
| EP2839004B1 (en) | 2019-06-12 |
| ES2732252T3 (es) | 2019-11-21 |
| US10443056B2 (en) | 2019-10-15 |
| EP2839004A1 (en) | 2015-02-25 |
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