MX2017004973A - Metodos y composiciones para tratar a un sujeto con un oligonucleotido antisentido de smad7. - Google Patents
Metodos y composiciones para tratar a un sujeto con un oligonucleotido antisentido de smad7.Info
- Publication number
- MX2017004973A MX2017004973A MX2017004973A MX2017004973A MX2017004973A MX 2017004973 A MX2017004973 A MX 2017004973A MX 2017004973 A MX2017004973 A MX 2017004973A MX 2017004973 A MX2017004973 A MX 2017004973A MX 2017004973 A MX2017004973 A MX 2017004973A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- treating
- subject
- antisense oligonucleotide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/34—Allele or polymorphism specific uses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
La presente invención se refiere al tratamiento de una enfermedad intestinal inflamatoria (por ejemplo, enfermedad de Crohn y colitis ulcerativa) utilizando nucleótidos antisentido que se dirigen contra formas polimórficas (por ejemplo, aquellas que contienen polimorfismos de de nucleótidos sencillos) del ARNm SMAD7; así, la invención se refiere a métodos de tratamiento para sujetos que tienen formas polimórficas de SMAD7 y oligloneuclótidos antisentido que hacen objetivo específicamente transcripciones de ARNm SMAD7 que contienen polimorfismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462065598P | 2014-10-17 | 2014-10-17 | |
PCT/EP2015/074066 WO2016059239A1 (en) | 2014-10-17 | 2015-10-16 | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017004973A true MX2017004973A (es) | 2017-12-07 |
Family
ID=54330761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017004973A MX2017004973A (es) | 2014-10-17 | 2015-10-16 | Metodos y composiciones para tratar a un sujeto con un oligonucleotido antisentido de smad7. |
Country Status (12)
Country | Link |
---|---|
US (2) | US10337004B2 (es) |
EP (1) | EP3207136A1 (es) |
JP (1) | JP2017532961A (es) |
KR (1) | KR20170069262A (es) |
CN (1) | CN107406851A (es) |
AU (1) | AU2015332624A1 (es) |
CA (1) | CA2964667A1 (es) |
EA (1) | EA201790867A1 (es) |
IL (1) | IL251717A0 (es) |
MA (1) | MA43331A (es) |
MX (1) | MX2017004973A (es) |
WO (1) | WO2016059239A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
EP2364360B1 (en) | 2008-11-13 | 2017-03-22 | Nogra Pharma Limited | Antisense compositions and methods of making and using same |
MX350087B (es) | 2011-09-15 | 2017-08-24 | Nogra Pharma Ltd | Metodos para vigilar la capacidad de respuesta a la terapia anti-smad7. |
AU2013249191B2 (en) | 2012-04-18 | 2019-01-03 | Nogra Pharma Limited | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
JP2017515896A (ja) | 2014-05-09 | 2017-06-15 | ノグラ ファーマ リミテッド | 炎症性腸疾患の処置の方法 |
EP3213070A2 (en) * | 2014-10-17 | 2017-09-06 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
EP3207136A1 (en) | 2014-10-17 | 2017-08-23 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
EP3420082A4 (en) * | 2016-02-23 | 2019-10-16 | Celgene Alpine Investment Company II, LLC | METHOD FOR THE TREATMENT OF DARM FIBROSIS USING SMAD7 INHIBITION |
WO2018122376A1 (en) * | 2016-12-30 | 2018-07-05 | Nogra Pharma Limited | Compositions of smad7 antisense oligonucleotide and methods of treating or preventing psoriasis |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1456380T3 (da) | 2001-11-02 | 2012-07-30 | Giuliani Int Ltd | SMAD7-inhibitorer til behandling af CNS-sygdomme |
ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
EP2364360B1 (en) | 2008-11-13 | 2017-03-22 | Nogra Pharma Limited | Antisense compositions and methods of making and using same |
WO2010085151A2 (en) * | 2009-01-26 | 2010-07-29 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Means and methods for modulating notch3 protein expression and/or the coding region of notch3; compositions and use thereof in the treatment of cadasil |
EP2534262B1 (en) * | 2010-02-08 | 2016-12-14 | Ionis Pharmaceuticals, Inc. | Selective reduction of allelic variants |
MX350087B (es) * | 2011-09-15 | 2017-08-24 | Nogra Pharma Ltd | Metodos para vigilar la capacidad de respuesta a la terapia anti-smad7. |
AU2013249191B2 (en) | 2012-04-18 | 2019-01-03 | Nogra Pharma Limited | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
RU2674147C2 (ru) | 2013-03-15 | 2018-12-05 | Ногра Фарма Лимитед | Способы лечения колоректального рака |
US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
JP2017515896A (ja) | 2014-05-09 | 2017-06-15 | ノグラ ファーマ リミテッド | 炎症性腸疾患の処置の方法 |
EP3213070A2 (en) | 2014-10-17 | 2017-09-06 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
EP3207135A2 (en) | 2014-10-17 | 2017-08-23 | Celgene Alpine Investment Company II, LLC | Isotopologues of smad7 antisense oligonucleotides |
EP3207136A1 (en) | 2014-10-17 | 2017-08-23 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
MA41271A (fr) | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
CA3000195A1 (en) | 2015-09-30 | 2017-04-06 | Celgene Alpine Investment Company Ii, Llc | Tlr modulators and methods of use |
EP3355896A2 (en) | 2015-09-30 | 2018-08-08 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
-
2015
- 2015-10-16 EP EP15781642.2A patent/EP3207136A1/en not_active Withdrawn
- 2015-10-16 CN CN201580069041.9A patent/CN107406851A/zh active Pending
- 2015-10-16 JP JP2017520449A patent/JP2017532961A/ja active Pending
- 2015-10-16 MA MA043331A patent/MA43331A/fr unknown
- 2015-10-16 AU AU2015332624A patent/AU2015332624A1/en not_active Abandoned
- 2015-10-16 KR KR1020177012839A patent/KR20170069262A/ko unknown
- 2015-10-16 CA CA2964667A patent/CA2964667A1/en not_active Abandoned
- 2015-10-16 EA EA201790867A patent/EA201790867A1/ru unknown
- 2015-10-16 US US15/519,468 patent/US10337004B2/en not_active Expired - Fee Related
- 2015-10-16 WO PCT/EP2015/074066 patent/WO2016059239A1/en active Application Filing
- 2015-10-16 MX MX2017004973A patent/MX2017004973A/es unknown
-
2017
- 2017-04-13 IL IL251717A patent/IL251717A0/en unknown
-
2019
- 2019-05-21 US US16/418,108 patent/US20190338283A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3207136A1 (en) | 2017-08-23 |
MA43331A (fr) | 2017-08-23 |
WO2016059239A1 (en) | 2016-04-21 |
EA201790867A1 (ru) | 2017-08-31 |
IL251717A0 (en) | 2017-06-29 |
US20190338283A1 (en) | 2019-11-07 |
CA2964667A1 (en) | 2016-04-21 |
AU2015332624A1 (en) | 2017-05-04 |
JP2017532961A (ja) | 2017-11-09 |
KR20170069262A (ko) | 2017-06-20 |
US20170240893A1 (en) | 2017-08-24 |
CN107406851A (zh) | 2017-11-28 |
US10337004B2 (en) | 2019-07-02 |
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