HK1259060A1 - 抑制腎素原基因或腎素原受體基因表達的單鏈核酸分子及其用途 - Google Patents

抑制腎素原基因或腎素原受體基因表達的單鏈核酸分子及其用途

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Publication number
HK1259060A1
HK1259060A1 HK19101560.7A HK19101560A HK1259060A1 HK 1259060 A1 HK1259060 A1 HK 1259060A1 HK 19101560 A HK19101560 A HK 19101560A HK 1259060 A1 HK1259060 A1 HK 1259060A1
Authority
HK
Hong Kong
Prior art keywords
prorenin
gene
nucleic acid
acid molecule
stranded nucleic
Prior art date
Application number
HK19101560.7A
Other languages
English (en)
Inventor
石田晉
神田敦宏
黑田雅彥
豊福秀一
Original Assignee
國立大學法人北海道大學
學校法人東京醫科大學
株式會社博納克
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 國立大學法人北海道大學, 學校法人東京醫科大學, 株式會社博納克 filed Critical 國立大學法人北海道大學
Publication of HK1259060A1 publication Critical patent/HK1259060A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
HK19101560.7A 2015-12-29 2019-01-29 抑制腎素原基因或腎素原受體基因表達的單鏈核酸分子及其用途 HK1259060A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015257713 2015-12-29
PCT/JP2016/089216 WO2017115872A1 (ja) 2015-12-29 2016-12-29 プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途

Publications (1)

Publication Number Publication Date
HK1259060A1 true HK1259060A1 (zh) 2019-11-22

Family

ID=59225198

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19101560.7A HK1259060A1 (zh) 2015-12-29 2019-01-29 抑制腎素原基因或腎素原受體基因表達的單鏈核酸分子及其用途

Country Status (12)

Country Link
US (1) US20190010503A1 (zh)
EP (1) EP3399037A4 (zh)
JP (2) JP6634095B2 (zh)
KR (1) KR102116922B1 (zh)
CN (1) CN108473988A (zh)
AU (1) AU2016382055C1 (zh)
BR (1) BR112018013323A2 (zh)
CA (1) CA3009769C (zh)
HK (1) HK1259060A1 (zh)
MX (1) MX2018008086A (zh)
RU (1) RU2718984C2 (zh)
WO (1) WO2017115872A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2697094C2 (ru) 2013-12-27 2019-08-12 Бонак Корпорейшн ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ
KR20170098914A (ko) 2014-12-27 2017-08-30 가부시키가이샤 보낙 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도
WO2016158809A1 (ja) 2015-03-27 2016-10-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
CN108004310B (zh) * 2017-12-13 2022-04-08 深圳大学 肾素(原)受体(p)rr基因及其抑制剂的应用
JP7250931B2 (ja) 2019-08-06 2023-04-03 日本曹達株式会社 金属張積層板用樹脂組成物、プリプレグ、及び金属張積層板

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US20050209141A1 (en) * 2003-10-17 2005-09-22 Silver Randi B Mast cell-derived renin
CN105251024A (zh) * 2004-08-23 2016-01-20 西伦蒂斯私人股份公司 眼病的治疗
EP1890152A1 (en) * 2006-08-14 2008-02-20 Charite Universitätsmedizin-Berlin Determination of renin/prorenin receptor activity
WO2009143619A1 (en) * 2008-05-27 2009-12-03 Chum Methods of treating or preventing obesity and obesity-related hypertension
SG196779A1 (en) * 2010-07-08 2014-02-13 Bonac Corp Single-strand nucleic acid molecule for controlling gene expression
WO2012017919A1 (ja) * 2010-08-03 2012-02-09 株式会社ボナック 含窒素脂環式骨格を有する一本鎖核酸分子
MX348971B (es) 2011-08-25 2017-07-05 Bonac Corp Compuesto de glicósido, método para producir tioéter, éter, método para producir éter, método para producir un compuesto de glicósido, método para producir ácido nucleico.
JP2013055913A (ja) * 2011-09-09 2013-03-28 Bonac Corp 遺伝子発現制御のための一本鎖ｒｎａ分子
WO2015093495A1 (ja) * 2013-12-16 2015-06-25 株式会社ボナック ＴＧＦ－β１遺伝子発現制御のための一本鎖核酸分子
KR20220087576A (ko) * 2014-05-22 2022-06-24 알닐람 파마슈티칼스 인코포레이티드 안지오텐시노겐 (ａｇｔ) ｉｒｎａ 조성물 및 이의 사용 방법

Also Published As

Publication number Publication date
JP2020031657A (ja) 2020-03-05
WO2017115872A1 (ja) 2017-07-06
RU2018127481A (ru) 2020-01-31
RU2718984C2 (ru) 2020-04-15
BR112018013323A2 (pt) 2018-12-11
AU2016382055C1 (en) 2020-06-04
EP3399037A4 (en) 2019-05-29
CA3009769C (en) 2021-01-12
KR102116922B1 (ko) 2020-06-01
JP6634095B2 (ja) 2020-01-22
KR20180086263A (ko) 2018-07-30
CA3009769A1 (en) 2017-07-06
US20190010503A1 (en) 2019-01-10
AU2016382055B2 (en) 2019-12-05
CN108473988A (zh) 2018-08-31
RU2018127481A3 (zh) 2020-01-31
AU2016382055A1 (en) 2018-07-26
JPWO2017115872A1 (ja) 2018-08-30
EP3399037A1 (en) 2018-11-07
JP6882741B2 (ja) 2021-06-02
MX2018008086A (es) 2018-11-12

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