|
US5032401A
(en)
|
1989-06-15 |
1991-07-16 |
Alpha Beta Technology |
Glucan drug delivery system and adjuvant
|
|
US7371580B2
(en)
|
2001-08-24 |
2008-05-13 |
Agilent Technologies, Inc. |
Use of unstructured nucleic acids in assaying nucleic acid molecules
|
|
US7740861B2
(en)
|
2004-06-16 |
2010-06-22 |
University Of Massachusetts |
Drug delivery product and methods
|
|
WO2008141248A2
(en)
|
2007-05-10 |
2008-11-20 |
Agilent Technologies, Inc. |
Thiocarbon-protecting groups for rna synthesis
|
|
US20100076183A1
(en)
|
2008-09-22 |
2010-03-25 |
Dellinger Douglas J |
Protected monomer and method of final deprotection for rna synthesis
|
|
US9585920B2
(en)
|
2011-02-04 |
2017-03-07 |
Katherine Rose Kovarik |
Method and system for treating cancer cachexia
|
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
CN104284669A
(zh)
|
2012-02-24 |
2015-01-14 |
弗雷德哈钦森癌症研究中心 |
治疗血红蛋白病的组合物和方法
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
EP3747891A3
(en)
|
2012-05-21 |
2021-03-24 |
Agilent Technologies, Inc. |
Compositions and methods for conjugating oligonucleotides
|
|
FI3597749T3
(fi)
|
2012-05-25 |
2023-10-09 |
Univ California |
Menetelmiä ja koostumuksia rna-ohjattua kohde-dna-modifikaatiota varten ja rna-ohjattua transkription modulaatiota varten
|
|
US20140075593A1
(en)
|
2012-09-07 |
2014-03-13 |
Dow Agrosciences Llc |
Fluorescence activated cell sorting (facs) enrichment to generate plants
|
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
CA2884162C
(en)
|
2012-09-07 |
2020-12-29 |
Dow Agrosciences Llc |
Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
|
|
KR101656236B1
(ko)
|
2012-10-23 |
2016-09-12 |
주식회사 툴젠 |
표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도
|
|
BR122019025681B1
(pt)
|
2012-11-01 |
2023-04-18 |
Factor Bioscience Inc |
Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
|
|
WO2014071235A1
(en)
|
2012-11-01 |
2014-05-08 |
Massachusetts Institute Of Technology |
Genetic device for the controlled destruction of dna
|
|
EP3401388B1
(en)
|
2012-12-06 |
2019-07-10 |
Synthetic Genomics, Inc. |
Algal mutants having a locked-in high light acclimated phenotype
|
|
US9447422B2
(en)
|
2012-12-06 |
2016-09-20 |
Synthetic Genomics, Inc. |
Autonomous replication sequences and episomal DNA molecules
|
|
PT3363902T
(pt)
|
2012-12-06 |
2019-12-19 |
Sigma Aldrich Co Llc |
Modificação e regulação de genoma baseadas em crispr
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP2932421A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
WO2014093688A1
(en)
|
2012-12-12 |
2014-06-19 |
1Massachusetts Institute Of Technology |
Compositions and methods for functional nucleic acid delivery
|
|
EP4234696A3
(en)
|
2012-12-12 |
2023-09-06 |
The Broad Institute Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
KR20150105956A
(ko)
|
2012-12-12 |
2015-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
PT2784162E
(pt)
|
2012-12-12 |
2015-08-27 |
Broad Inst Inc |
Engenharia de sistemas, métodos e composições guia otimizadas para a manipulação de sequências
|
|
EP4282970A3
(en)
|
2012-12-17 |
2024-01-17 |
President and Fellows of Harvard College |
Rna-guided human genome engineering
|
|
US20160138027A1
(en)
|
2013-03-14 |
2016-05-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
|
|
AU2014235794A1
(en)
|
2013-03-14 |
2015-10-22 |
Caribou Biosciences, Inc. |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
WO2014159719A1
(en)
|
2013-03-14 |
2014-10-02 |
Scrips Health |
Methods of isolating nucleic acids
|
|
US9957515B2
(en)
|
2013-03-15 |
2018-05-01 |
Cibus Us Llc |
Methods and compositions for targeted gene modification
|
|
KR102874079B1
(ko)
|
2013-03-15 |
2025-10-22 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
US20140364333A1
(en)
|
2013-03-15 |
2014-12-11 |
President And Fellows Of Harvard College |
Methods for Live Imaging of Cells
|
|
US20140273235A1
(en)
|
2013-03-15 |
2014-09-18 |
Regents Of The University Of Minnesota |
ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS
|
|
US20140349400A1
(en)
|
2013-03-15 |
2014-11-27 |
Massachusetts Institute Of Technology |
Programmable Modification of DNA
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
EP2971006A4
(en)
|
2013-03-15 |
2017-02-08 |
Transposagen Biopharmaceuticals, Inc. |
Reproducible method for testis-mediated genetic modification (tgm) and sperm-mediated genetic modification (sgm)
|
|
US11274305B2
(en)
|
2013-04-04 |
2022-03-15 |
Trustees Of Dartmouth College |
Compositions and methods for in vivo excision of HIV-1 proviral DNA
|
|
EP2981617B1
(en)
|
2013-04-04 |
2023-07-05 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
WO2014172458A1
(en)
|
2013-04-16 |
2014-10-23 |
University Of Washington Through Its Center For Commercialization |
Activating an alternative pathway for homology-directed repair to stimulate targeted gene correction and genome engineering
|
|
EP3456831B1
(en)
|
2013-04-16 |
2021-07-14 |
Regeneron Pharmaceuticals, Inc. |
Targeted modification of rat genome
|
|
WO2014172470A2
(en)
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
|
AU2014265331B2
(en)
|
2013-05-15 |
2019-12-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
US9873907B2
(en)
|
2013-05-29 |
2018-01-23 |
Agilent Technologies, Inc. |
Method for fragmenting genomic DNA using CAS9
|
|
US11685935B2
(en)
|
2013-05-29 |
2023-06-27 |
Cellectis |
Compact scaffold of Cas9 in the type II CRISPR system
|
|
EP3004349B1
(en)
|
2013-05-29 |
2018-03-28 |
Cellectis S.A. |
A method for producing precise dna cleavage using cas9 nickase activity
|
|
DK3004337T3
(da)
|
2013-05-29 |
2017-11-13 |
Cellectis |
Fremgangsmåde til konstruktion af T-celler til immunoterapi ved brug af RNA-guidet Cas nuklease-system
|
|
RU2690935C2
(ru)
|
2013-06-04 |
2019-06-06 |
Президент Энд Фэллоуз Оф Харвард Коллидж |
Направляемая рнк регуляция транскрипции
|
|
US9982277B2
(en)
|
2013-06-11 |
2018-05-29 |
The Regents Of The University Of California |
Methods and compositions for target DNA modification
|
|
US20150315252A1
(en)
|
2013-06-11 |
2015-11-05 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
JP6738729B2
(ja)
|
2013-06-17 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
CN107995927B
(zh)
|
2013-06-17 |
2021-07-30 |
布罗德研究所有限公司 |
用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途
|
|
EP3011035B1
(en)
|
2013-06-17 |
2020-05-13 |
The Broad Institute, Inc. |
Assay for quantitative evaluation of target site cleavage by one or more crispr-cas guide sequences
|
|
CA2917638C
(en)
|
2013-07-09 |
2024-09-10 |
Harvard College |
RNA MULTIPLEX GUIDED GENOMIC ENGINEERING
|
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
|
EP3019005B1
(en)
|
2013-07-10 |
2019-02-20 |
EffStock, LLC |
Mrap2 knockouts
|
|
SG10201800213VA
(en)
|
2013-07-10 |
2018-02-27 |
Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
EP3611268A1
(en)
|
2013-08-22 |
2020-02-19 |
E. I. du Pont de Nemours and Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
AU2014315335B2
(en)
|
2013-09-04 |
2017-08-24 |
Corteva Agriscience Llc |
Rapid targeting analysis in crops for determining donor insertion
|
|
WO2015035034A1
(en)
|
2013-09-04 |
2015-03-12 |
Mice With Horns, Llc |
Materials and methods for correcting recessive mutations in animals
|
|
WO2015033293A1
(en)
|
2013-09-04 |
2015-03-12 |
Csir |
Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US20150071946A1
(en)
|
2013-09-06 |
2015-03-12 |
The Johns Hopkins University |
Tumor-specific retrotransposon insertions
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
EP3988649B1
(en)
|
2013-09-18 |
2024-11-27 |
Kymab Limited |
Methods, cells and organisms
|
|
WO2015040075A1
(en)
|
2013-09-18 |
2015-03-26 |
Genome Research Limited |
Genomic screening methods using rna-guided endonucleases
|
|
US20150098954A1
(en)
|
2013-10-08 |
2015-04-09 |
Elwha Llc |
Compositions and Methods Related to CRISPR Targeting
|
|
DE102013111099B4
(de)
|
2013-10-08 |
2023-11-30 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA
|
|
WO2015052231A2
(en)
|
2013-10-08 |
2015-04-16 |
Technical University Of Denmark |
Multiplex editing system
|
|
AU2014331939A1
(en)
|
2013-10-08 |
2016-04-28 |
Amelia HENRY |
Drought-resistant cereal grasses and related materials and methods
|
|
EP3862434A1
(en)
|
2013-11-04 |
2021-08-11 |
Dow AgroSciences LLC |
Optimal soybean loci
|
|
BR102014027442B1
(pt)
|
2013-11-04 |
2022-09-27 |
Dow Agrosciences Llc |
Molécula de ácido nucleico recombinante, uso de uma planta de milho, parte de planta de milho ou célula de planta de milho compreendendo a mesma e método para produzir uma célula vegetal transgênica compreendendo um dna de interesse
|
|
WO2015066638A2
(en)
|
2013-11-04 |
2015-05-07 |
Dow Agrosciences Llc |
Optimal maize loci
|
|
US10233465B2
(en)
|
2013-11-04 |
2019-03-19 |
Dow Agrosciences Llc |
Optimal soybean loci
|
|
AU2014341928B2
(en)
|
2013-11-04 |
2017-11-30 |
Corteva Agriscience Llc |
A universal donor system for gene targeting
|
|
WO2015070062A1
(en)
|
2013-11-07 |
2015-05-14 |
Massachusetts Institute Of Technology |
Cell-based genomic recorded accumulative memory
|
|
KR20230054509A
(ko)
|
2013-11-07 |
2023-04-24 |
에디타스 메디신, 인코포레이티드 |
지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
|
|
WO2015075056A1
(en)
|
2013-11-19 |
2015-05-28 |
Thermo Fisher Scientific Baltics Uab |
Programmable enzymes for isolation of specific dna fragments
|
|
US9074199B1
(en)
|
2013-11-19 |
2015-07-07 |
President And Fellows Of Harvard College |
Mutant Cas9 proteins
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
EP3080266B1
(en)
|
2013-12-12 |
2021-02-03 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
EP3540051B1
(en)
|
2013-12-12 |
2022-08-17 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hsv and viral diseases and disorders.
|
|
US11053481B2
(en)
|
2013-12-12 |
2021-07-06 |
President And Fellows Of Harvard College |
Fusions of Cas9 domains and nucleic acid-editing domains
|
|
SG10201804973TA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Compositions and Methods of Use of Crispr-Cas Systems in Nucleotide Repeat Disorders
|
|
EP3079726B1
(en)
|
2013-12-12 |
2018-12-05 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
BR112016013201B1
(pt)
|
2013-12-12 |
2023-01-31 |
The Broad Institute, Inc. |
Uso de uma composição compreendendo um sistema crispr-cas no tratamento de uma doença genética ocular
|
|
JP2017503485A
(ja)
|
2013-12-12 |
2017-02-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
遺伝子産物の発現、構造情報、及び誘導性モジュラーcas酵素を変更するためのcrispr−cas系並びに方法
|
|
EP3126498A4
(en)
|
2014-03-20 |
2017-08-23 |
Université Laval |
Crispr-based methods and products for increasing frataxin levels and uses thereof
|
|
US20160060655A1
(en)
|
2014-05-30 |
2016-03-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods to treat latent viral infections
|
|
US20150344836A1
(en)
|
2014-05-30 |
2015-12-03 |
Ohio State Innovation Foundation |
Agrobacterium Strains for Plant Transformation and Related Materials and Methods
|
|
MX384887B
(es)
|
2014-06-23 |
2025-03-14 |
Regeneron Pharma |
Ensamblaje de adn mediado por nucleasa.
|
|
IL286474B2
(en)
|
2014-06-23 |
2023-11-01 |
Massachusetts Gen Hospital |
Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
|
|
WO2015200725A1
(en)
|
2014-06-25 |
2015-12-30 |
Cold Spring Harbor Laboratory |
Methods and compositions for inhibiting growth and epithelial to mesenchymal transition (emt) in cancer cells
|
|
WO2015200555A2
(en)
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
US9616090B2
(en)
|
2014-07-30 |
2017-04-11 |
Sangamo Biosciences, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US9932566B2
(en)
|
2014-08-07 |
2018-04-03 |
Agilent Technologies, Inc. |
CIS-blocked guide RNA
|
|
CN113584015B
(zh)
|
2014-08-27 |
2025-05-02 |
新英格兰生物实验室公司 |
合成子的形成
|
|
US9970030B2
(en)
|
2014-08-27 |
2018-05-15 |
Caribou Biosciences, Inc. |
Methods for increasing CAS9-mediated engineering efficiency
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
CN107002140A
(zh)
|
2014-09-26 |
2017-08-01 |
双孔人公司 |
通过合成探针的纳米孔隙探测的靶序列检测
|
|
BR112017003842B1
(pt)
|
2014-09-26 |
2024-02-20 |
Philip Morris Products S.A. |
Método para produção de um produto de tabaco
|
|
US11015209B2
(en)
|
2014-09-26 |
2021-05-25 |
Pioneer Hi-Bred International, Inc. |
Wheat MS1 polynucleotides, polypeptides, and methods of use
|
|
WO2016073079A2
(en)
|
2014-09-26 |
2016-05-12 |
Yale University |
Compositions and methods for biocontainment of microorganisms
|
|
CN107106615A
(zh)
|
2014-10-09 |
2017-08-29 |
人类起源公司 |
胎盘来源的贴壁细胞外泌体及其用途
|
|
EP3204513A2
(en)
|
2014-10-09 |
2017-08-16 |
Life Technologies Corporation |
Crispr oligonucleotides and gene editing
|
|
US20170354745A1
(en)
|
2014-10-09 |
2017-12-14 |
The Regents Of The University Of California |
Targeted disruption of a csf1-dap12 pathway member gene for the treatment of neuropathic pain
|
|
JP6788584B2
(ja)
|
2014-10-31 |
2020-11-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
Crisprについての超並列コンビナトリアル遺伝学
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
EP4427809A3
(en)
|
2014-10-31 |
2024-12-04 |
The Trustees of The University of Pennsylvania |
Altering gene expression in car-t cells and uses thereof
|
|
CN107250148B
(zh)
*
|
2014-12-03 |
2021-04-16 |
安捷伦科技有限公司 |
具有化学修饰的指导rna
|
|
EP3234133B1
(en)
*
|
2014-12-18 |
2020-11-11 |
Integrated DNA Technologies, Inc. |
Crispr-based compositions and methods of use
|
|
RU2713328C2
(ru)
|
2015-01-28 |
2020-02-04 |
Пайонир Хай-Бред Интернэшнл, Инк. |
Гибридные днк/рнк-полинуклеотиды crispr и способы применения
|
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
EP3159407A1
(en)
|
2015-10-23 |
2017-04-26 |
Silence Therapeutics (London) Ltd |
Guide rnas, methods and uses
|
|
US11761007B2
(en)
|
2015-12-18 |
2023-09-19 |
The Scripps Research Institute |
Production of unnatural nucleotides using a CRISPR/Cas9 system
|
|
WO2017106569A1
(en)
|
2015-12-18 |
2017-06-22 |
The Regents Of The University Of California |
Modified site-directed modifying polypeptides and methods of use thereof
|
|
FI3390632T3
(fi)
|
2015-12-18 |
2025-11-25 |
Danisco Us Inc |
Menetelmät ja koostumukset polymeraasi ii (pol-ii) -pohjaisen opas-rna:n ilmentämiseen
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
CN109072218B
(zh)
|
2015-12-18 |
2023-04-18 |
国立研究开发法人科学技术振兴机构 |
基因修饰非人生物、卵细胞、受精卵以及目的基因的修饰方法
|
|
EP3390631B1
(en)
|
2015-12-18 |
2020-04-08 |
Danisco US Inc. |
Methods and compositions for t-rna based guide rna expression
|
|
US11845933B2
(en)
|
2016-02-03 |
2023-12-19 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide RNA and its applications
|
|
US10767175B2
(en)
*
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CN110291198B
(zh)
|
2016-12-08 |
2024-11-26 |
因特利亚治疗公司 |
经修饰的指导rna
|