JP2020532961A5 - - Google Patents
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- Publication number
- JP2020532961A5 JP2020532961A5 JP2020508506A JP2020508506A JP2020532961A5 JP 2020532961 A5 JP2020532961 A5 JP 2020532961A5 JP 2020508506 A JP2020508506 A JP 2020508506A JP 2020508506 A JP2020508506 A JP 2020508506A JP 2020532961 A5 JP2020532961 A5 JP 2020532961A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- adenine
- nucleotides
- poly
- adenine nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023137160A JP2023179428A (ja) | 2017-08-15 | 2023-08-25 | メッセンジャーリボ核酸（ｍＲＮＡ）をコードする安定化された核酸 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762545883P | 2017-08-15 | 2017-08-15 | |
| US62/545,883 | 2017-08-15 | ||
| PCT/US2018/046772 WO2019036513A1 (en) | 2017-08-15 | 2018-08-14 | STABILIZED NUCLEIC ACIDS ENCODING MESSENGER RIBONUCLEIC ACID (MRNA) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023137160A Division JP2023179428A (ja) | 2017-08-15 | 2023-08-25 | メッセンジャーリボ核酸（ｍＲＮＡ）をコードする安定化された核酸 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532961A JP2020532961A (ja) | 2020-11-19 |
| JP2020532961A5 true JP2020532961A5 (enExample) | 2021-09-30 |
Family
ID=63638316
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508506A Pending JP2020532961A (ja) | 2017-08-15 | 2018-08-14 | メッセンジャーリボ核酸（ｍＲＮＡ）をコードする安定化された核酸 |
| JP2023137160A Pending JP2023179428A (ja) | 2017-08-15 | 2023-08-25 | メッセンジャーリボ核酸（ｍＲＮＡ）をコードする安定化された核酸 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023137160A Pending JP2023179428A (ja) | 2017-08-15 | 2023-08-25 | メッセンジャーリボ核酸（ｍＲＮＡ）をコードする安定化された核酸 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11673911B2 (enExample) |
| EP (1) | EP3668980A1 (enExample) |
| JP (2) | JP2020532961A (enExample) |
| KR (2) | KR102740888B1 (enExample) |
| CN (2) | CN111212908B (enExample) |
| AU (2) | AU2018318135B2 (enExample) |
| BR (1) | BR112020003026A2 (enExample) |
| CA (1) | CA3072960A1 (enExample) |
| CO (1) | CO2020002989A2 (enExample) |
| MX (1) | MX2020001821A (enExample) |
| WO (1) | WO2019036513A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2018119010A1 (en) | 2016-12-19 | 2018-06-28 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| WO2018129368A2 (en) | 2017-01-06 | 2018-07-12 | Editas Medicine, Inc. | Methods of assessing nuclease cleavage |
| EP3615672A1 (en) | 2017-04-28 | 2020-03-04 | Editas Medicine, Inc. | Methods and systems for analyzing guide rna molecules |
| EP3635104A1 (en) | 2017-06-09 | 2020-04-15 | Editas Medicine, Inc. | Engineered cas9 nucleases |
| WO2019014564A1 (en) | 2017-07-14 | 2019-01-17 | Editas Medicine, Inc. | SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES |
| KR102740888B1 (ko) * | 2017-08-15 | 2024-12-13 | 인텔리아 테라퓨틱스, 인크. | 메신저 리보핵산(mRNA)을 암호화하는 안정화된 핵산 |
| KR102832035B1 (ko) * | 2017-09-29 | 2025-07-09 | 인텔리아 테라퓨틱스, 인크. | 지질 나노파티클을 이용한 mRNA 전달의 체외 방법 |
| AU2019291918B2 (en) | 2018-06-29 | 2025-06-12 | Editas Medicine, Inc. | Synthetic guide molecules, compositions and methods relating thereto |
| AU2020379046B2 (en) | 2019-11-08 | 2025-03-13 | Regeneron Pharmaceuticals, Inc. | CRISPR and AAV strategies for X-linked juvenile retinoschisis therapy |
| CN117836418A (zh) * | 2021-08-17 | 2024-04-05 | 爱思开生物科技有限公司 | 稳定保持聚a尾的方法 |
| EP4442830A4 (en) | 2021-11-29 | 2025-04-30 | Shanghai Regenelead Therapies Co., Ltd. | AADC/GDNF polynucleotide and use thereof in the treatment of Parkinson's disease |
| AU2023220237A1 (en) | 2022-02-21 | 2024-08-15 | Shanghai Regenelead Therapies Co., Ltd | Vegf-binding molecule and pharmaceutical use thereof |
| CN117701602A (zh) * | 2022-08-26 | 2024-03-15 | 深圳瑞吉生物科技有限公司 | 在宿主细胞中稳定存在的多段化PolyA多核苷酸及其应用 |
| EP4674967A1 (en) * | 2023-03-01 | 2026-01-07 | Rinuagene Biotechnology Co., Ltd. | Engineered dna molecule for coding rna |
| CN119799695A (zh) * | 2023-10-10 | 2025-04-11 | 深圳瑞吉生物科技有限公司 | 提高mRNA稳定性以及蛋白表达的多元polyA多核苷酸及其应用 |
| PL446809A1 (pl) * | 2023-11-22 | 2025-05-26 | Sieć Badawcza Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii | Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| GB202406051D0 (en) | 2024-04-30 | 2024-06-12 | Univ Oxford Innovation Ltd | Segmented poly(a) tails |
| WO2026006390A2 (en) | 2024-06-26 | 2026-01-02 | Intellia Therapeutics, Inc. | Modified guide rnas for genome editing |
| WO2026046276A1 (zh) * | 2024-08-29 | 2026-03-05 | 仁景(苏州)生物科技有限公司 | 一种多价流感mRNA疫苗 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08131163A (ja) * | 1994-11-11 | 1996-05-28 | Sankyo Co Ltd | ドメイン変換ヘアピン型リボザイム |
| JP2002360299A (ja) * | 2001-04-20 | 2002-12-17 | Seiwa Technics:Kk | ｍＲＮＡの不安定性を利用したサイトカインの３’非翻訳領域を組み込んだトランスジェニックマウスのガン、炎症などの病変部位検出方法 |
| WO2012019630A1 (en) * | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2013120500A1 (en) * | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| WO2016005004A1 (en) * | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| US9943612B2 (en) * | 2014-10-09 | 2018-04-17 | Seattle Children's Hospital | Long poly(A) plasmids and methods for introduction of long poly(A) sequences into the plasmid |
| MA41349A (fr) * | 2015-01-14 | 2017-11-21 | Univ Temple | Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn |
| EP3085714B1 (en) * | 2015-04-21 | 2018-03-14 | Rohm And Haas Company | Co2 abating latex coating composition |
| WO2017059902A1 (en) * | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| KR101786396B1 (ko) * | 2016-10-27 | 2017-11-24 | 서울대학교산학협력단 | 전령 rna의 3′말단 서열 분석 방법 |
| KR102740888B1 (ko) * | 2017-08-15 | 2024-12-13 | 인텔리아 테라퓨틱스, 인크. | 메신저 리보핵산(mRNA)을 암호화하는 안정화된 핵산 |
-
2018
- 2018-08-14 KR KR1020207007211A patent/KR102740888B1/ko active Active
- 2018-08-14 CN CN201880066328.XA patent/CN111212908B/zh active Active
- 2018-08-14 MX MX2020001821A patent/MX2020001821A/es unknown
- 2018-08-14 CA CA3072960A patent/CA3072960A1/en active Pending
- 2018-08-14 KR KR1020247040420A patent/KR20250004924A/ko active Pending
- 2018-08-14 EP EP18772961.1A patent/EP3668980A1/en active Pending
- 2018-08-14 JP JP2020508506A patent/JP2020532961A/ja active Pending
- 2018-08-14 WO PCT/US2018/046772 patent/WO2019036513A1/en not_active Ceased
- 2018-08-14 AU AU2018318135A patent/AU2018318135B2/en active Active
- 2018-08-14 CN CN202510029728.5A patent/CN119899831A/zh active Pending
- 2018-08-14 BR BR112020003026-0A patent/BR112020003026A2/pt unknown
-
2020
- 2020-02-14 US US16/791,076 patent/US11673911B2/en active Active
- 2020-03-13 CO CONC2020/0002989A patent/CO2020002989A2/es unknown
-
2023
- 2023-05-01 US US18/310,298 patent/US12391722B2/en active Active
- 2023-08-25 JP JP2023137160A patent/JP2023179428A/ja active Pending
-
2024
- 2024-12-04 AU AU2024278094A patent/AU2024278094A1/en not_active Abandoned
-
2025
- 2025-07-22 US US19/276,658 patent/US20250346625A1/en active Pending
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