BR112020003026A2 - ácidos nucleicos estabilizados codificando ácido ribonucleico mensageiro (mrna) - Google Patents
ácidos nucleicos estabilizados codificando ácido ribonucleico mensageiro (mrna) Download PDFInfo
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- BR112020003026A2 BR112020003026A2 BR112020003026-0A BR112020003026A BR112020003026A2 BR 112020003026 A2 BR112020003026 A2 BR 112020003026A2 BR 112020003026 A BR112020003026 A BR 112020003026A BR 112020003026 A2 BR112020003026 A2 BR 112020003026A2
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- adenine
- nucleotides
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- dna
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20180250424A1 (en) | 2014-10-10 | 2018-09-06 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2018119010A1 (en) | 2016-12-19 | 2018-06-28 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| US12110545B2 (en) | 2017-01-06 | 2024-10-08 | Editas Medicine, Inc. | Methods of assessing nuclease cleavage |
| EP3615672A1 (en) | 2017-04-28 | 2020-03-04 | Editas Medicine, Inc. | Methods and systems for analyzing guide rna molecules |
| CN110997908A (zh) | 2017-06-09 | 2020-04-10 | 爱迪塔斯医药公司 | 工程化的cas9核酸酶 |
| WO2019014564A1 (en) | 2017-07-14 | 2019-01-17 | Editas Medicine, Inc. | SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES |
| MX2020001821A (es) * | 2017-08-15 | 2020-09-18 | Intellia Therapeutics Inc | Ácidos nucleicos estabilizados que codifican el ácido ribonucleico mensajero (arnm). |
| KR102832035B1 (ko) * | 2017-09-29 | 2025-07-09 | 인텔리아 테라퓨틱스, 인크. | 지질 나노파티클을 이용한 mRNA 전달의 체외 방법 |
| CA3104856A1 (en) | 2018-06-29 | 2020-01-02 | Editas Medicine, Inc. | Synthetic guide molecules, compositions and methods relating thereto |
| WO2023022490A1 (ko) * | 2021-08-17 | 2023-02-23 | 에스케이바이오사이언스 주식회사 | 폴리 a 테일을 안정적으로 유지하는 방법 |
| US20250051750A1 (en) | 2021-11-29 | 2025-02-13 | Shanghai Regenelead Therapies Co., Ltd. | Aadc/gdnf polynucleotide, and use thereof in treating parkinson's disease |
| AU2023220237A1 (en) | 2022-02-21 | 2024-08-15 | Shanghai Regenelead Therapies Co., Ltd | Vegf-binding molecule and pharmaceutical use thereof |
| CN117701602A (zh) * | 2022-08-26 | 2024-03-15 | 深圳瑞吉生物科技有限公司 | 在宿主细胞中稳定存在的多段化PolyA多核苷酸及其应用 |
| KR20250161542A (ko) * | 2023-03-01 | 2025-11-17 | 리누아진 바이오테크놀로지 씨오., 엘티디. | Rna를 코딩하기 위한 조작된 dna 분자 |
| CN119799695A (zh) * | 2023-10-10 | 2025-04-11 | 深圳瑞吉生物科技有限公司 | 提高mRNA稳定性以及蛋白表达的多元polyA多核苷酸及其应用 |
| PL446809A1 (pl) * | 2023-11-22 | 2025-05-26 | Sieć Badawcza Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii | Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| GB202406051D0 (en) | 2024-04-30 | 2024-06-12 | Univ Oxford Innovation Ltd | Segmented poly(a) tails |
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| JPH08131163A (ja) * | 1994-11-11 | 1996-05-28 | Sankyo Co Ltd | ドメイン変換ヘアピン型リボザイム |
| JP2002360299A (ja) * | 2001-04-20 | 2002-12-17 | Seiwa Technics:Kk | ｍＲＮＡの不安定性を利用したサイトカインの３’非翻訳領域を組み込んだトランスジェニックマウスのガン、炎症などの病変部位検出方法 |
| WO2012019630A1 (en) * | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2013120500A1 (en) * | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| WO2016005004A1 (en) * | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
| US9943612B2 (en) * | 2014-10-09 | 2018-04-17 | Seattle Children's Hospital | Long poly(A) plasmids and methods for introduction of long poly(A) sequences into the plasmid |
| MA41349A (fr) * | 2015-01-14 | 2017-11-21 | Univ Temple | Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn |
| EP3085714B1 (en) * | 2015-04-21 | 2018-03-14 | Rohm And Haas Company | Co2 abating latex coating composition |
| WO2017059902A1 (en) * | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| KR101786396B1 (ko) * | 2016-10-27 | 2017-11-24 | 서울대학교산학협력단 | 전령 rna의 3′말단 서열 분석 방법 |
| MX2020001821A (es) * | 2017-08-15 | 2020-09-18 | Intellia Therapeutics Inc | Ácidos nucleicos estabilizados que codifican el ácido ribonucleico mensajero (arnm). |
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| WO2019036513A1 (en) | 2019-02-21 |
| KR20250004924A (ko) | 2025-01-08 |
| US20250346625A1 (en) | 2025-11-13 |
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| AU2018318135B2 (en) | 2024-09-12 |
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| AU2018318135A1 (en) | 2020-03-05 |
| US11673911B2 (en) | 2023-06-13 |
| MX2020001821A (es) | 2020-09-18 |
| KR102740888B1 (ko) | 2024-12-13 |
| US20230271997A1 (en) | 2023-08-31 |
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