PL446809A1 - Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie - Google Patents

Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie

Info

Publication number
PL446809A1
PL446809A1 PL446809A PL44680923A PL446809A1 PL 446809 A1 PL446809 A1 PL 446809A1 PL 446809 A PL446809 A PL 446809A PL 44680923 A PL44680923 A PL 44680923A PL 446809 A1 PL446809 A1 PL 446809A1
Authority
PL
Poland
Prior art keywords
modified
applications
end sequences
rna molecules
mrna
Prior art date
Application number
PL446809A
Other languages
English (en)
Inventor
Tomasz ŚPIEWLA
Joanna Kowalska
Jacek Jemielity
Dominika Nowis
Karol Czubak
Jakub GOŁĄB
Seweryn MROCZEK
Paweł Krawczyk
Andrzej DZIEMBOWSKI
Original Assignee
Sieć Badawcza Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sieć Badawcza Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii filed Critical Sieć Badawcza Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii
Priority to PL446809A priority Critical patent/PL446809A1/pl
Priority to PCT/PL2024/050093 priority patent/WO2025110887A1/en
Publication of PL446809A1 publication Critical patent/PL446809A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Przedmiotem zgłoszenia są zmodyfikowane sekwencje końca 3' mRNA, kodujące je sekwencje DNA oraz ich zastosowania jako ulepszenie narzędzia molekularnego mRNA dla szerokiego zakresu terapii medycznych opartych na cząsteczkach mRNA.
PL446809A 2023-11-22 2023-11-22 Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie PL446809A1 (pl)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL446809A PL446809A1 (pl) 2023-11-22 2023-11-22 Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie
PCT/PL2024/050093 WO2025110887A1 (en) 2023-11-22 2024-11-22 Rna molecules with modified 3' terminal sequences and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL446809A PL446809A1 (pl) 2023-11-22 2023-11-22 Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie

Publications (1)

Publication Number Publication Date
PL446809A1 true PL446809A1 (pl) 2025-05-26

Family

ID=93962509

Family Applications (1)

Application Number Title Priority Date Filing Date
PL446809A PL446809A1 (pl) 2023-11-22 2023-11-22 Cząsteczki RNA ze zmodyfikowanymi sekwencjami końca 3' i ich zastosowanie

Country Status (2)

Country Link
PL (1) PL446809A1 (pl)
WO (1) WO2025110887A1 (pl)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019036513A1 (en) * 2017-08-15 2019-02-21 Intellia Therapeutics, Inc. STABILIZED NUCLEIC ACIDS ENCODING MESSENGER RIBONUCLEIC ACID (MRNA)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040248170A1 (en) * 1999-01-06 2004-12-09 Chondrogene Limited Method for the detection of hyperlipidemia related gene transcripts in blood
WO2016005004A1 (en) 2014-07-11 2016-01-14 Biontech Rna Pharmaceuticals Gmbh Stabilization of poly(a) sequence encoding dna sequences
US20230279408A1 (en) 2020-08-07 2023-09-07 The Hong Kong University Of Science And Technology Compositions and methods for increasing protein expression

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019036513A1 (en) * 2017-08-15 2019-02-21 Intellia Therapeutics, Inc. STABILIZED NUCLEIC ACIDS ENCODING MESSENGER RIBONUCLEIC ACID (MRNA)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TREPOTEC Z ET AL.: "RNA, 2019 Apr; 25(4): 507-518", SEGMENTED POLY(A) TAILS SIGNIFICANTLY REDUCE RECOMBINATION OF PLASMID DNA WITHOUT AFFECTING MRNA TRANSLATION EFFICIENCY OR HALF-LIFE *

Also Published As

Publication number Publication date
WO2025110887A1 (en) 2025-05-30

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