JP2019506889A5 - - Google Patents
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- JP2019506889A5 JP2019506889A5 JP2018546429A JP2018546429A JP2019506889A5 JP 2019506889 A5 JP2019506889 A5 JP 2019506889A5 JP 2018546429 A JP2018546429 A JP 2018546429A JP 2018546429 A JP2018546429 A JP 2018546429A JP 2019506889 A5 JP2019506889 A5 JP 2019506889A5
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- JP
- Japan
- Prior art keywords
- nucleic acid
- cedna
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- stem
- rolling circle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021179896A JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303047P | 2016-03-03 | 2016-03-03 | |
| US62/303,047 | 2016-03-03 | ||
| US201662394720P | 2016-09-14 | 2016-09-14 | |
| US62/394,720 | 2016-09-14 | ||
| US201662406913P | 2016-10-11 | 2016-10-11 | |
| US62/406,913 | 2016-10-11 | ||
| PCT/US2017/020828 WO2017152149A1 (en) | 2016-03-03 | 2017-03-03 | Closed-ended linear duplex dna for non-viral gene transfer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179896A Division JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506889A JP2019506889A (ja) | 2019-03-14 |
| JP2019506889A5 true JP2019506889A5 (enExample) | 2020-04-09 |
| JP6994140B2 JP6994140B2 (ja) | 2022-02-03 |
Family
ID=59743259
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546429A Active JP6994140B2 (ja) | 2016-03-03 | 2017-03-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
| JP2021179896A Active JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
| JP2022191114A Pending JP2023024489A (ja) | 2016-03-03 | 2022-11-30 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179896A Active JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
| JP2022191114A Pending JP2023024489A (ja) | 2016-03-03 | 2022-11-30 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11066679B2 (enExample) |
| EP (2) | EP3423110B1 (enExample) |
| JP (3) | JP6994140B2 (enExample) |
| KR (1) | KR102336362B1 (enExample) |
| CN (2) | CN109195636B (enExample) |
| AU (2) | AU2017228413B2 (enExample) |
| CA (1) | CA3014683A1 (enExample) |
| DK (1) | DK3423110T3 (enExample) |
| ES (1) | ES2898337T3 (enExample) |
| HR (1) | HRP20211697T1 (enExample) |
| IL (2) | IL302398B2 (enExample) |
| LT (1) | LT3423110T (enExample) |
| MX (1) | MX2018010633A (enExample) |
| PT (1) | PT3423110T (enExample) |
| RU (1) | RU2752882C2 (enExample) |
| SG (2) | SG10201913688TA (enExample) |
| WO (1) | WO2017152149A1 (enExample) |
| ZA (1) | ZA201806544B (enExample) |
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| CN107106689A (zh) | 2014-11-05 | 2017-08-29 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
| CN112410338A (zh) | 2014-11-14 | 2021-02-26 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| IL292999A (en) | 2014-11-14 | 2022-07-01 | Voyager Therapeutics Inc | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| WO2016094783A1 (en) | 2014-12-12 | 2016-06-16 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scaav |
| SG10201913688TA (en) | 2016-03-03 | 2020-03-30 | Univ Massachusetts | Closed-ended linear duplex dna for non-viral gene transfer |
| SG11201809699XA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Modulatory polynucleotides |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
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| MX2020002501A (es) * | 2017-09-08 | 2020-09-17 | Generation Bio Co | Formulaciones de nanoparticulas lipidas de vectores de adn libres de capsidos, no virales. |
| CN111132699A (zh) * | 2017-09-08 | 2020-05-08 | 世代生物公司 | 修饰的封闭端dna(cedna) |
| EP3684422B1 (en) | 2017-09-20 | 2023-12-20 | The Regents of the University of California | Connexin-43 gene therapy to restore electrical and cardiac function, and cardiac structure, in arrhythmogenic right ventricular cardiomyopathy |
| US12098385B2 (en) | 2017-09-20 | 2024-09-24 | The Regents Of The University Of California | Gene therapy strategy to restore cardiac electrical and structural function in arrhythmogenic right ventricular cardiomyopathy |
| WO2019079362A1 (en) * | 2017-10-16 | 2019-04-25 | Massachusetts Institute Of Technology | HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS |
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| JP2021513999A (ja) * | 2018-02-22 | 2021-06-03 | ジェネレーション バイオ カンパニー | 閉端ｄｎａ（ｃｅｄｎａ）ベクターを使用した導入遺伝子の制御された発現 |
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| US20210346306A1 (en) | 2018-05-23 | 2021-11-11 | Modernatx, Inc. | Delivery of dna |
| WO2019237391A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | CRISPR/Cas9 靶向敲除人 TXGP1 基因及其特异性 gRNA |
| WO2019237383A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 用于人 tnfsf18 基因编辑的修饰载体、其制备方法及应用 |
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| KR102925832B1 (ko) | 2018-08-09 | 2026-02-11 | 바이오버라티브 테라퓨틱스 인크. | 핵산 분자 및 비바이러스 유전자 치료를 위한 이의 용도 |
| US20210310000A1 (en) * | 2018-08-17 | 2021-10-07 | City Of Hope | Compounds of chemically modified oligonucleotides and methods of use thereof |
| CN113383010B (zh) | 2018-09-28 | 2025-09-09 | 沃雅戈治疗公司 | 具有经工程化改造的启动子的共济蛋白表达构建体及其使用方法 |
| AU2019376663A1 (en) * | 2018-11-09 | 2021-06-24 | Generation Bio Co. | Modified closed-ended DNA (ceDNA) comprising symmetrical modified inverted terminal repeats |
| MX2021008874A (es) * | 2019-01-24 | 2021-08-19 | Generation Bio Co | Adn de extremo cerrado (ceadn) y uso en metodos de reduccion de la respuesta inmunitaria relacionada con tratamiento genico o de acido nucleico. |
| SG11202106491VA (en) * | 2019-02-15 | 2021-07-29 | Generation Bio Co | Modulation of rep protein activity in closed-ended dna (cedna) production |
| MA55223A (fr) * | 2019-03-06 | 2022-01-12 | Generation Bio Co | Adn à extrémité fermée (cedna) et composés de modulation immunitaire |
| EP3934700A4 (en) * | 2019-03-06 | 2022-12-14 | Generation Bio Co. | NON-ACTIVE LIPID NANOPARTICLES WITH CAPSID-FREE, NON-VIRAL DNA |
| JP7583732B2 (ja) | 2019-03-13 | 2024-11-14 | ジェネレーション バイオ カンパニー | フェニルアラニンヒドロキシラーゼ（ｐａｈ）治療薬を発現するための非ウイルス性ｄｎａベクターおよびその使用 |
| BR112021017853A2 (pt) * | 2019-03-13 | 2021-11-30 | Generation Bio Co | Vetores de dna não virais e usos dos mesmos para expressar terapêuticas de fviii |
| US12582726B1 (en) | 2019-04-05 | 2026-03-24 | Earli Inc. | Synthetic cancer-specific promoters |
| CA3132338A1 (en) * | 2019-04-05 | 2020-10-08 | David Suhy | Improved methods and compositions for synthetic biomarkers |
| CA3147414A1 (en) | 2019-07-17 | 2021-01-21 | Generation Bio Co. | Synthetic production of single-stranded adeno associated viral dna vectors |
| GB2606844B (en) | 2019-09-18 | 2025-08-06 | Aldevron Llc | Synthetic DNA vectors and methods of use |
| WO2021173647A1 (en) | 2020-02-25 | 2021-09-02 | University Of Massachusetts | Inducible single aav system and uses thereof |
| AU2021244555A1 (en) * | 2020-03-24 | 2022-11-24 | Generation Bio Co. | Non-viral dna vectors and uses thereof for expressing factor ix therapeutics |
| US12534435B2 (en) | 2020-03-27 | 2026-01-27 | Generation Bio Co. | Lipids and nanoparticle compositions thereof |
| US20210330759A1 (en) * | 2020-04-22 | 2021-10-28 | The Cleveland Clinic Foundation | Methods and compositions for treating cytokine storm, ards, and acute lung injury using beta-glucocerebrosidase |
| CA3184474A1 (en) | 2020-06-01 | 2021-12-09 | Modernatx, Inc. | Phenylalanine hydroxylase variants and uses thereof |
| WO2022023284A1 (en) | 2020-07-27 | 2022-02-03 | Anjarium Biosciences Ag | Compositions of dna molecules, methods of making therefor, and methods of use thereof |
| US20220090130A1 (en) | 2020-08-23 | 2022-03-24 | Bioverativ Therapeutics Inc. | MODIFIED BACULOVIRUS SYSTEM FOR IMPROVED PRODUCTION OF CLOSED-ENDED DNA (ceDNA) |
| MX2023003021A (es) * | 2020-09-16 | 2023-05-24 | Generation Bio Co | Vectores de adn no virales y usos de estos para expresar agentes terapéuticos con fviii. |
| US20240261395A1 (en) * | 2021-05-07 | 2024-08-08 | Generation Bio Co. | Lyophilized non-viral dna vector compositions and uses thereof |
| KR20240005903A (ko) * | 2021-05-07 | 2024-01-12 | 제너레이션 바이오 컴퍼니 | 백신 전달을 위한 비바이러스성 dna 벡터 |
| EP4337177A1 (en) | 2021-05-11 | 2024-03-20 | Modernatx, Inc. | Non-viral delivery of dna for prolonged polypeptide expression in vivo |
| JP2024534123A (ja) | 2021-08-23 | 2024-09-18 | バイオベラティブ セラピューティクス インコーポレイテッド | バキュロウイルス発現システム |
| JP2024534159A (ja) * | 2021-08-23 | 2024-09-18 | アビラマックス・バイオファーマ・インコーポレイテッド | 導入遺伝子発現のための組成物および方法 |
| CN114525282A (zh) * | 2022-03-04 | 2022-05-24 | 西南大学 | 一种二价核酸适配体及其设计方法 |
| AU2024222598A1 (en) * | 2023-02-17 | 2025-07-31 | Flagship Pioneering Innovations Vii, Llc | Dna compositions comprising modified uracil |
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| WO2024249438A1 (en) * | 2023-05-26 | 2024-12-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Copiparvovirus genetic vector platform |
| WO2025212926A1 (en) * | 2024-04-05 | 2025-10-09 | University Of Massachusetts | Aav-mediated rhoa knockdown |
| WO2026085495A1 (en) | 2024-10-18 | 2026-04-23 | Generation Bio Co. | Synthetic partially single-stranded nucleic acid compositions and uses and methods therefor |
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| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
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| SG10201913688TA (en) | 2016-03-03 | 2020-03-30 | Univ Massachusetts | Closed-ended linear duplex dna for non-viral gene transfer |
-
2017
- 2017-03-03 SG SG10201913688TA patent/SG10201913688TA/en unknown
- 2017-03-03 SG SG11201806663TA patent/SG11201806663TA/en unknown
- 2017-03-03 CN CN201780014840.5A patent/CN109195636B/zh active Active
- 2017-03-03 AU AU2017228413A patent/AU2017228413B2/en active Active
- 2017-03-03 IL IL302398A patent/IL302398B2/en unknown
- 2017-03-03 EP EP17760963.3A patent/EP3423110B1/en active Active
- 2017-03-03 MX MX2018010633A patent/MX2018010633A/es unknown
- 2017-03-03 PT PT177609633T patent/PT3423110T/pt unknown
- 2017-03-03 DK DK17760963.3T patent/DK3423110T3/da active
- 2017-03-03 ES ES17760963T patent/ES2898337T3/es active Active
- 2017-03-03 IL IL261524A patent/IL261524B2/en unknown
- 2017-03-03 CA CA3014683A patent/CA3014683A1/en active Pending
- 2017-03-03 KR KR1020187028000A patent/KR102336362B1/ko active Active
- 2017-03-03 RU RU2018134295A patent/RU2752882C2/ru active
- 2017-03-03 EP EP21183431.2A patent/EP3957331A1/en active Pending
- 2017-03-03 LT LTEPPCT/US2017/020828T patent/LT3423110T/lt unknown
- 2017-03-03 HR HRP20211697TT patent/HRP20211697T1/hr unknown
- 2017-03-03 WO PCT/US2017/020828 patent/WO2017152149A1/en not_active Ceased
- 2017-03-03 CN CN202210722790.9A patent/CN115287301A/zh active Pending
- 2017-03-03 US US16/081,337 patent/US11066679B2/en active Active
- 2017-03-03 JP JP2018546429A patent/JP6994140B2/ja active Active
-
2018
- 2018-10-02 ZA ZA2018/06544A patent/ZA201806544B/en unknown
-
2021
- 2021-06-01 US US17/335,499 patent/US12252703B2/en active Active
- 2021-11-03 JP JP2021179896A patent/JP7193096B2/ja active Active
-
2022
- 2022-11-30 JP JP2022191114A patent/JP2023024489A/ja active Pending
-
2025
- 2025-02-13 US US19/052,351 patent/US20250290094A1/en active Pending
- 2025-04-17 AU AU2025202724A patent/AU2025202724A1/en active Pending
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