JP2019506889A5 - - Google Patents
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- JP2019506889A5 JP2019506889A5 JP2018546429A JP2018546429A JP2019506889A5 JP 2019506889 A5 JP2019506889 A5 JP 2019506889A5 JP 2018546429 A JP2018546429 A JP 2018546429A JP 2018546429 A JP2018546429 A JP 2018546429A JP 2019506889 A5 JP2019506889 A5 JP 2019506889A5
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- JP
- Japan
- Prior art keywords
- nucleic acid
- cedna
- optionally
- stem
- rolling circle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021179896A JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303047P | 2016-03-03 | 2016-03-03 | |
| US62/303,047 | 2016-03-03 | ||
| US201662394720P | 2016-09-14 | 2016-09-14 | |
| US62/394,720 | 2016-09-14 | ||
| US201662406913P | 2016-10-11 | 2016-10-11 | |
| US62/406,913 | 2016-10-11 | ||
| PCT/US2017/020828 WO2017152149A1 (en) | 2016-03-03 | 2017-03-03 | Closed-ended linear duplex dna for non-viral gene transfer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179896A Division JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506889A JP2019506889A (ja) | 2019-03-14 |
| JP2019506889A5 true JP2019506889A5 (enExample) | 2020-04-09 |
| JP6994140B2 JP6994140B2 (ja) | 2022-02-03 |
Family
ID=59743259
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546429A Active JP6994140B2 (ja) | 2016-03-03 | 2017-03-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
| JP2021179896A Active JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
| JP2022191114A Pending JP2023024489A (ja) | 2016-03-03 | 2022-11-30 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021179896A Active JP7193096B2 (ja) | 2016-03-03 | 2021-11-03 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
| JP2022191114A Pending JP2023024489A (ja) | 2016-03-03 | 2022-11-30 | 非ウイルス的遺伝子導入のための閉鎖型直鎖状二重鎖ｄｎａ |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11066679B2 (enExample) |
| EP (2) | EP3957331A1 (enExample) |
| JP (3) | JP6994140B2 (enExample) |
| KR (1) | KR102336362B1 (enExample) |
| CN (2) | CN115287301B (enExample) |
| AU (2) | AU2017228413B2 (enExample) |
| CA (1) | CA3014683A1 (enExample) |
| DK (1) | DK3423110T3 (enExample) |
| ES (1) | ES2898337T3 (enExample) |
| HR (1) | HRP20211697T1 (enExample) |
| IL (2) | IL261524B2 (enExample) |
| LT (1) | LT3423110T (enExample) |
| MX (1) | MX2018010633A (enExample) |
| PT (1) | PT3423110T (enExample) |
| RU (1) | RU2752882C2 (enExample) |
| SG (2) | SG11201806663TA (enExample) |
| WO (1) | WO2017152149A1 (enExample) |
| ZA (1) | ZA201806544B (enExample) |
Families Citing this family (61)
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| EP3215191B1 (en) | 2014-11-05 | 2024-08-14 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
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| US10584337B2 (en) | 2016-05-18 | 2020-03-10 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
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| US12098385B2 (en) | 2017-09-20 | 2024-09-24 | The Regents Of The University Of California | Gene therapy strategy to restore cardiac electrical and structural function in arrhythmogenic right ventricular cardiomyopathy |
| WO2019060619A1 (en) | 2017-09-20 | 2019-03-28 | The Regents Of The University Of California | STRATEGY OF GENE THERAPY FOR RESTORING ELECTRICAL AND CARDIAC FUNCTION AND CARDIAC STRUCTURE IN ARYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY |
| WO2019079362A1 (en) * | 2017-10-16 | 2019-04-25 | Massachusetts Institute Of Technology | HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS |
| JP2021505159A (ja) * | 2017-12-06 | 2021-02-18 | ジェネレーション バイオ カンパニー | 修飾型閉端ｄｎａ（ｃｅｄｎａ）を使用する遺伝子編集 |
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| CA3092459A1 (en) * | 2018-03-02 | 2019-09-06 | Generation Bio Co. | Closed-ended dna (cedna) vectors for insertion of transgenes at genomic safe harbors (gsh) in humans and murine genomes |
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| WO2019191109A1 (en) * | 2018-03-28 | 2019-10-03 | The Board Of Trustees Of The Leland Stanford Junior University | Microrna inhibitors and their use in treating epiretinal membranes |
| CN112424359A (zh) | 2018-05-15 | 2021-02-26 | 沃雅戈治疗公司 | 用于治疗帕金森氏病的组合物和方法 |
| MA52709A (fr) | 2018-05-23 | 2021-03-31 | Modernatx Inc | Administration d'adn |
| WO2019237391A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | CRISPR/Cas9 靶向敲除人 TXGP1 基因及其特异性 gRNA |
| WO2019237383A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 用于人 tnfsf18 基因编辑的修饰载体、其制备方法及应用 |
| CN112639110A (zh) * | 2018-06-22 | 2021-04-09 | 阿斯克肋匹奥生物制药公司 | 用于基因递送以在细胞内持续存在的载体 |
| JP7602454B2 (ja) | 2018-08-09 | 2024-12-18 | バイオベラティブ セラピューティクス インコーポレイテッド | 核酸分子及び非ウイルス遺伝子治療のためのそれらの使用 |
| WO2020037254A1 (en) * | 2018-08-17 | 2020-02-20 | City Of Hope | Compounds of chemically modified oligonucleotides and methods of use thereof |
| US12281321B2 (en) | 2018-09-28 | 2025-04-22 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| WO2020097417A1 (en) * | 2018-11-09 | 2020-05-14 | Generation Bio Co. | Modified closed-ended dna (cedna) comprising symmetrical modified inverted terminal repeats |
| KR20210119416A (ko) * | 2019-01-24 | 2021-10-05 | 제너레이션 바이오 컴퍼니 | 폐쇄-말단 dna (cedna), 및 유전자 또는 핵산 치료 관련 면역 반응을 감소시키는 방법에서의 이의 용도 |
| CA3129321A1 (en) * | 2019-02-15 | 2020-08-20 | Generation Bio Co. | Modulation of rep protein activity in closed-ended dna (cedna) production |
| AU2020232790A1 (en) * | 2019-03-06 | 2021-09-16 | Generation Bio Co. | Non-active lipid nanoparticles with non-viral, capsid free DNA |
| SG11202108864UA (en) * | 2019-03-06 | 2021-09-29 | Generation Bio Co | Closed-ended dna (cedna) and immune modulating compounds |
| KR20210151785A (ko) * | 2019-03-13 | 2021-12-14 | 제너레이션 바이오 컴퍼니 | 비바이러스성 dna 벡터 및 fviii 치료제 발현을 위한 이의 용도 |
| US12415002B2 (en) * | 2019-03-13 | 2025-09-16 | Generation Bio Co. | Non-viral DNA vectors and uses thereof for expressing phenylalanine hydroxylase (PAH) therapeutics |
| US12582726B1 (en) | 2019-04-05 | 2026-03-24 | Earli Inc. | Synthetic cancer-specific promoters |
| EP3946470A4 (en) | 2019-04-05 | 2023-05-31 | Earli Inc. | IMPROVED METHODS AND COMPOSITIONS FOR SYNTHETIC BIOMARKERS |
| WO2021011842A1 (en) | 2019-07-17 | 2021-01-21 | Generation Bio Co. | Synthetic production of single-stranded adeno associated viral dna vectors |
| WO2021055760A1 (en) | 2019-09-18 | 2021-03-25 | Intergalactic Therapeutics, Inc. | Synthetic dna vectors and methods of use |
| US20230089312A1 (en) | 2020-02-25 | 2023-03-23 | University Of Massachusetts | Inducible single aav system and uses thereof |
| IL296660A (en) * | 2020-03-24 | 2022-11-01 | Generation Bio Co | Non-viral DNA vectors and their use for therapeutic expression of factor ix |
| US12534435B2 (en) | 2020-03-27 | 2026-01-27 | Generation Bio Co. | Lipids and nanoparticle compositions thereof |
| US20210330759A1 (en) * | 2020-04-22 | 2021-10-28 | The Cleveland Clinic Foundation | Methods and compositions for treating cytokine storm, ards, and acute lung injury using beta-glucocerebrosidase |
| AU2021285812A1 (en) | 2020-06-01 | 2023-01-05 | Modernatx, Inc. | Phenylalanine hydroxylase variants and uses thereof |
| MX2023001109A (es) | 2020-07-27 | 2023-04-24 | Anjarium Biosciences Ag | Composiciones de moleculas de adn, metodos para elaborar las mismas, y metodos de usos de las mismas. |
| AU2021330936A1 (en) | 2020-08-23 | 2023-05-04 | Bioverativ Therapeutics Inc. | MODIFIED BACULOVIRUS SYSTEM FOR IMPROVED PRODUCTION OF CLOSED-ENDED DNA (ceDNA) |
| MX2023003019A (es) * | 2020-09-16 | 2023-05-08 | Generation Bio Co | Vectores de adn de extremo cerrado y usos de estos para expresar fenilalanina hidroxilasa (pah). |
| CA3191743A1 (en) * | 2020-09-16 | 2022-03-24 | Generation Bio Co. | Non-viral dna vectors and uses thereof for expressing fviii therapeutics |
| EP4333886A4 (en) * | 2021-05-07 | 2025-11-12 | Generation Bio Co | NON-VIRAL DNA VECTORS FOR VACCINE ADMINISTRATION |
| WO2022236016A1 (en) * | 2021-05-07 | 2022-11-10 | Generation Bio Co. | Lyophilized non-viral dna vector compositions and uses thereof |
| WO2022240806A1 (en) | 2021-05-11 | 2022-11-17 | Modernatx, Inc. | Non-viral delivery of dna for prolonged polypeptide expression in vivo |
| JP2024534159A (ja) * | 2021-08-23 | 2024-09-18 | アビラマックス・バイオファーマ・インコーポレイテッド | 導入遺伝子発現のための組成物および方法 |
| WO2023028440A2 (en) | 2021-08-23 | 2023-03-02 | Bioverativ Therapeutics Inc. | Baculovirus expression system |
| CN114525282A (zh) * | 2022-03-04 | 2022-05-24 | 西南大学 | 一种二价核酸适配体及其设计方法 |
| KR20250151437A (ko) * | 2023-02-17 | 2025-10-21 | 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 | 변형된 우라실을 포함하는 dna 조성물 |
| US12383615B2 (en) | 2023-03-23 | 2025-08-12 | Carbon Biosciences, Inc. | Protoparvovirus compositions comprising a protoparvovirus variant VP1 capsid polypeptide and related methods |
| WO2024249438A1 (en) * | 2023-05-26 | 2024-12-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Copiparvovirus genetic vector platform |
| WO2025212926A1 (en) * | 2024-04-05 | 2025-10-09 | University Of Massachusetts | Aav-mediated rhoa knockdown |
| US20260000702A1 (en) | 2024-06-26 | 2026-01-01 | Flagship Pioneering Innovations Vii, Llc | Therapeutic circular dna forms |
| WO2026085495A1 (en) | 2024-10-18 | 2026-04-23 | Generation Bio Co. | Synthetic partially single-stranded nucleic acid compositions and uses and methods therefor |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| US5252334A (en) | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
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| JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
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-
2017
- 2017-03-03 IL IL261524A patent/IL261524B2/en unknown
- 2017-03-03 HR HRP20211697TT patent/HRP20211697T1/hr unknown
- 2017-03-03 WO PCT/US2017/020828 patent/WO2017152149A1/en not_active Ceased
- 2017-03-03 MX MX2018010633A patent/MX2018010633A/es unknown
- 2017-03-03 CA CA3014683A patent/CA3014683A1/en active Pending
- 2017-03-03 PT PT177609633T patent/PT3423110T/pt unknown
- 2017-03-03 ES ES17760963T patent/ES2898337T3/es active Active
- 2017-03-03 KR KR1020187028000A patent/KR102336362B1/ko active Active
- 2017-03-03 AU AU2017228413A patent/AU2017228413B2/en active Active
- 2017-03-03 SG SG11201806663TA patent/SG11201806663TA/en unknown
- 2017-03-03 IL IL302398A patent/IL302398B2/en unknown
- 2017-03-03 CN CN202210722790.9A patent/CN115287301B/zh active Active
- 2017-03-03 EP EP21183431.2A patent/EP3957331A1/en active Pending
- 2017-03-03 EP EP17760963.3A patent/EP3423110B1/en active Active
- 2017-03-03 LT LTEPPCT/US2017/020828T patent/LT3423110T/lt unknown
- 2017-03-03 RU RU2018134295A patent/RU2752882C2/ru active
- 2017-03-03 SG SG10201913688TA patent/SG10201913688TA/en unknown
- 2017-03-03 CN CN201780014840.5A patent/CN109195636B/zh active Active
- 2017-03-03 JP JP2018546429A patent/JP6994140B2/ja active Active
- 2017-03-03 US US16/081,337 patent/US11066679B2/en active Active
- 2017-03-03 DK DK17760963.3T patent/DK3423110T3/da active
-
2018
- 2018-10-02 ZA ZA2018/06544A patent/ZA201806544B/en unknown
-
2021
- 2021-06-01 US US17/335,499 patent/US12252703B2/en active Active
- 2021-11-03 JP JP2021179896A patent/JP7193096B2/ja active Active
-
2022
- 2022-11-30 JP JP2022191114A patent/JP2023024489A/ja active Pending
-
2025
- 2025-02-13 US US19/052,351 patent/US20250290094A1/en active Pending
- 2025-04-17 AU AU2025202724A patent/AU2025202724A1/en active Pending
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