RU2752882C2 - Линейная дуплексная днк с закрытым концом для невирусного переноса генов - Google Patents
Линейная дуплексная днк с закрытым концом для невирусного переноса генов Download PDFInfo
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- RU2752882C2 RU2752882C2 RU2018134295A RU2018134295A RU2752882C2 RU 2752882 C2 RU2752882 C2 RU 2752882C2 RU 2018134295 A RU2018134295 A RU 2018134295A RU 2018134295 A RU2018134295 A RU 2018134295A RU 2752882 C2 RU2752882 C2 RU 2752882C2
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303047P | 2016-03-03 | 2016-03-03 | |
| US62/303,047 | 2016-03-03 | ||
| US201662394720P | 2016-09-14 | 2016-09-14 | |
| US62/394,720 | 2016-09-14 | ||
| US201662406913P | 2016-10-11 | 2016-10-11 | |
| US62/406,913 | 2016-10-11 | ||
| PCT/US2017/020828 WO2017152149A1 (en) | 2016-03-03 | 2017-03-03 | Closed-ended linear duplex dna for non-viral gene transfer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018134295A RU2018134295A (ru) | 2020-04-06 |
| RU2018134295A3 RU2018134295A3 (enExample) | 2020-06-29 |
| RU2752882C2 true RU2752882C2 (ru) | 2021-08-11 |
Family
ID=59743259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018134295A RU2752882C2 (ru) | 2016-03-03 | 2017-03-03 | Линейная дуплексная днк с закрытым концом для невирусного переноса генов |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11066679B2 (enExample) |
| EP (2) | EP3957331A1 (enExample) |
| JP (3) | JP6994140B2 (enExample) |
| KR (1) | KR102336362B1 (enExample) |
| CN (2) | CN115287301B (enExample) |
| AU (2) | AU2017228413B2 (enExample) |
| CA (1) | CA3014683A1 (enExample) |
| DK (1) | DK3423110T3 (enExample) |
| ES (1) | ES2898337T3 (enExample) |
| HR (1) | HRP20211697T1 (enExample) |
| IL (2) | IL261524B2 (enExample) |
| LT (1) | LT3423110T (enExample) |
| MX (1) | MX2018010633A (enExample) |
| PT (1) | PT3423110T (enExample) |
| RU (1) | RU2752882C2 (enExample) |
| SG (2) | SG11201806663TA (enExample) |
| WO (1) | WO2017152149A1 (enExample) |
| ZA (1) | ZA201806544B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2800914C2 (ru) * | 2018-02-14 | 2023-08-01 | Дженерейшен Био Ко. | Невирусные днк-векторы и их применение для продуцирования антител и слитых белков |
Families Citing this family (61)
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| EP3215191B1 (en) | 2014-11-05 | 2024-08-14 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| IL261524B2 (en) | 2016-03-03 | 2023-10-01 | Univ Massachusetts | End-capped linear double-stranded DNA for non-viral gene transfer |
| US10584337B2 (en) | 2016-05-18 | 2020-03-10 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| MX2020001593A (es) | 2017-08-09 | 2020-07-13 | Bioverativ Therapeutics Inc | Moleculas de acido nucleico y usos de las mismas. |
| EP3679148A4 (en) * | 2017-09-08 | 2021-06-09 | Generation Bio Co. | LIPID NANOPARTICLE FORMULATIONS FROM NONVIRAL, CAPSID-FREE DNA VECTORS |
| CA3075168A1 (en) * | 2017-09-08 | 2019-03-14 | Generation Bio Co. | Modified closed-ended dna (cedna) |
| US12098385B2 (en) | 2017-09-20 | 2024-09-24 | The Regents Of The University Of California | Gene therapy strategy to restore cardiac electrical and structural function in arrhythmogenic right ventricular cardiomyopathy |
| WO2019060619A1 (en) | 2017-09-20 | 2019-03-28 | The Regents Of The University Of California | STRATEGY OF GENE THERAPY FOR RESTORING ELECTRICAL AND CARDIAC FUNCTION AND CARDIAC STRUCTURE IN ARYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY |
| WO2019079362A1 (en) * | 2017-10-16 | 2019-04-25 | Massachusetts Institute Of Technology | HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS |
| JP2021505159A (ja) * | 2017-12-06 | 2021-02-18 | ジェネレーション バイオ カンパニー | 修飾型閉端dna(cedna)を使用する遺伝子編集 |
| WO2019126222A1 (en) * | 2017-12-18 | 2019-06-27 | Spark Therapeutics, Inc. | Adeno-associated virus (aav) vector lipid nanoparticle compositions and methods of use |
| JP2021511047A (ja) | 2018-01-19 | 2021-05-06 | ジェネレーション バイオ カンパニー | 無細胞合成から得ることができる閉端DNAベクターおよびceDNAベクターを得るためのプロセス |
| AU2019221642A1 (en) * | 2018-02-14 | 2020-07-09 | Generation Bio Co. | Non-viral DNA vectors and uses thereof for antibody and fusion protein production |
| EP3755803A4 (en) * | 2018-02-22 | 2022-01-19 | Generation Bio Co. | CONTROLLED EXPRESSION OF TRANSGENES USING DNA (CEDNA) VECTORS |
| CA3092459A1 (en) * | 2018-03-02 | 2019-09-06 | Generation Bio Co. | Closed-ended dna (cedna) vectors for insertion of transgenes at genomic safe harbors (gsh) in humans and murine genomes |
| MX2020009579A (es) * | 2018-03-15 | 2020-11-09 | Intergalactic Therapeutics Inc | Vectores de adn sintetico y metodos de uso. |
| WO2019191109A1 (en) * | 2018-03-28 | 2019-10-03 | The Board Of Trustees Of The Leland Stanford Junior University | Microrna inhibitors and their use in treating epiretinal membranes |
| CN112424359A (zh) | 2018-05-15 | 2021-02-26 | 沃雅戈治疗公司 | 用于治疗帕金森氏病的组合物和方法 |
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| WO2019237383A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 用于人 tnfsf18 基因编辑的修饰载体、其制备方法及应用 |
| CN112639110A (zh) * | 2018-06-22 | 2021-04-09 | 阿斯克肋匹奥生物制药公司 | 用于基因递送以在细胞内持续存在的载体 |
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| WO2020037254A1 (en) * | 2018-08-17 | 2020-02-20 | City Of Hope | Compounds of chemically modified oligonucleotides and methods of use thereof |
| US12281321B2 (en) | 2018-09-28 | 2025-04-22 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| WO2020097417A1 (en) * | 2018-11-09 | 2020-05-14 | Generation Bio Co. | Modified closed-ended dna (cedna) comprising symmetrical modified inverted terminal repeats |
| KR20210119416A (ko) * | 2019-01-24 | 2021-10-05 | 제너레이션 바이오 컴퍼니 | 폐쇄-말단 dna (cedna), 및 유전자 또는 핵산 치료 관련 면역 반응을 감소시키는 방법에서의 이의 용도 |
| CA3129321A1 (en) * | 2019-02-15 | 2020-08-20 | Generation Bio Co. | Modulation of rep protein activity in closed-ended dna (cedna) production |
| AU2020232790A1 (en) * | 2019-03-06 | 2021-09-16 | Generation Bio Co. | Non-active lipid nanoparticles with non-viral, capsid free DNA |
| SG11202108864UA (en) * | 2019-03-06 | 2021-09-29 | Generation Bio Co | Closed-ended dna (cedna) and immune modulating compounds |
| KR20210151785A (ko) * | 2019-03-13 | 2021-12-14 | 제너레이션 바이오 컴퍼니 | 비바이러스성 dna 벡터 및 fviii 치료제 발현을 위한 이의 용도 |
| US12415002B2 (en) * | 2019-03-13 | 2025-09-16 | Generation Bio Co. | Non-viral DNA vectors and uses thereof for expressing phenylalanine hydroxylase (PAH) therapeutics |
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| WO2021011842A1 (en) | 2019-07-17 | 2021-01-21 | Generation Bio Co. | Synthetic production of single-stranded adeno associated viral dna vectors |
| WO2021055760A1 (en) | 2019-09-18 | 2021-03-25 | Intergalactic Therapeutics, Inc. | Synthetic dna vectors and methods of use |
| US20230089312A1 (en) | 2020-02-25 | 2023-03-23 | University Of Massachusetts | Inducible single aav system and uses thereof |
| IL296660A (en) * | 2020-03-24 | 2022-11-01 | Generation Bio Co | Non-viral DNA vectors and their use for therapeutic expression of factor ix |
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