CN109195636B - 用于非病毒基因转移的末端封闭型线性双链体dna - Google Patents
用于非病毒基因转移的末端封闭型线性双链体dna Download PDFInfo
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- CN109195636B CN109195636B CN201780014840.5A CN201780014840A CN109195636B CN 109195636 B CN109195636 B CN 109195636B CN 201780014840 A CN201780014840 A CN 201780014840A CN 109195636 B CN109195636 B CN 109195636B
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210722790.9A CN115287301A (zh) | 2016-03-03 | 2017-03-03 | 用于非病毒基因转移的末端封闭型线性双链体dna |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662303047P | 2016-03-03 | 2016-03-03 | |
| US62/303,047 | 2016-03-03 | ||
| US201662394720P | 2016-09-14 | 2016-09-14 | |
| US62/394,720 | 2016-09-14 | ||
| US201662406913P | 2016-10-11 | 2016-10-11 | |
| US62/406,913 | 2016-10-11 | ||
| PCT/US2017/020828 WO2017152149A1 (en) | 2016-03-03 | 2017-03-03 | Closed-ended linear duplex dna for non-viral gene transfer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210722790.9A Division CN115287301A (zh) | 2016-03-03 | 2017-03-03 | 用于非病毒基因转移的末端封闭型线性双链体dna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109195636A CN109195636A (zh) | 2019-01-11 |
| CN109195636B true CN109195636B (zh) | 2022-07-05 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780014840.5A Active CN109195636B (zh) | 2016-03-03 | 2017-03-03 | 用于非病毒基因转移的末端封闭型线性双链体dna |
| CN202210722790.9A Pending CN115287301A (zh) | 2016-03-03 | 2017-03-03 | 用于非病毒基因转移的末端封闭型线性双链体dna |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210722790.9A Pending CN115287301A (zh) | 2016-03-03 | 2017-03-03 | 用于非病毒基因转移的末端封闭型线性双链体dna |
Country Status (18)
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| EP (2) | EP3423110B1 (enExample) |
| JP (3) | JP6994140B2 (enExample) |
| KR (1) | KR102336362B1 (enExample) |
| CN (2) | CN109195636B (enExample) |
| AU (2) | AU2017228413B2 (enExample) |
| CA (1) | CA3014683A1 (enExample) |
| DK (1) | DK3423110T3 (enExample) |
| ES (1) | ES2898337T3 (enExample) |
| HR (1) | HRP20211697T1 (enExample) |
| IL (2) | IL302398B2 (enExample) |
| LT (1) | LT3423110T (enExample) |
| MX (1) | MX2018010633A (enExample) |
| PT (1) | PT3423110T (enExample) |
| RU (1) | RU2752882C2 (enExample) |
| SG (2) | SG11201806663TA (enExample) |
| WO (1) | WO2017152149A1 (enExample) |
| ZA (1) | ZA201806544B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201703148TA (en) | 2014-11-05 | 2017-05-30 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
| MX2017006217A (es) | 2014-11-14 | 2018-05-02 | Voyager Therapeutics Inc | Polinucleotidos moduladores. |
| US10597660B2 (en) | 2014-11-14 | 2020-03-24 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| HK1245326A1 (zh) | 2014-12-12 | 2018-08-24 | Voyager Therapeutics, Inc. | 用於生产scaav的组合物和方法 |
| EP3423110B1 (en) | 2016-03-03 | 2021-08-11 | University of Massachusetts | Closed-ended linear duplex dna for non-viral gene transfer |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CN111247251B (zh) | 2017-08-09 | 2025-06-27 | 比奥维拉迪维治疗股份有限公司 | 核酸分子及其用途 |
| SG11202000765PA (en) * | 2017-09-08 | 2020-03-30 | Generation Bio Co | Lipid nanoparticle formulations of non-viral, capsid-free dna vectors |
| KR20200051011A (ko) * | 2017-09-08 | 2020-05-12 | 제너레이션 바이오 컴퍼니 | 변형된 폐쇄-종결된 dna(cedna) |
| WO2019060619A1 (en) | 2017-09-20 | 2019-03-28 | The Regents Of The University Of California | STRATEGY OF GENE THERAPY FOR RESTORING ELECTRICAL AND CARDIAC FUNCTION AND CARDIAC STRUCTURE IN ARYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY |
| US12098385B2 (en) | 2017-09-20 | 2024-09-24 | The Regents Of The University Of California | Gene therapy strategy to restore cardiac electrical and structural function in arrhythmogenic right ventricular cardiomyopathy |
| WO2019079362A1 (en) * | 2017-10-16 | 2019-04-25 | Massachusetts Institute Of Technology | HOST-PATHOGENIC INTERACTION OF MYCOBACTERIUM TUBERCULOSIS |
| US20220290186A1 (en) * | 2017-12-06 | 2022-09-15 | Generation Bio Co. | Gene editing using a modified closed-ended dna (cedna) |
| WO2019126222A1 (en) * | 2017-12-18 | 2019-06-27 | Spark Therapeutics, Inc. | Adeno-associated virus (aav) vector lipid nanoparticle compositions and methods of use |
| UA130154C2 (uk) * | 2018-01-19 | 2025-12-03 | Дженератіон Біо Ко. | Спосіб безклітинного одержання днк-вектора з замкненими кінцями |
| BR112020016288A2 (pt) * | 2018-02-14 | 2020-12-15 | Generation Bio Co. | Vetores de dna não virais e usos dos mesmos para produção de anticorpos e proteínas de fusão |
| BR112020017060A2 (pt) * | 2018-02-22 | 2020-12-15 | Generation Bio Co. | Expressão controlada de transgenes usando vetores de dna de extremidade fechada (cedna) |
| WO2019169233A1 (en) * | 2018-03-02 | 2019-09-06 | Generation Bio Co. | Closed-ended dna (cedna) vectors for insertion of transgenes at genomic safe harbors (gsh) in humans and murine genomes |
| CA3092088A1 (en) * | 2018-03-15 | 2019-09-19 | Igtx, Llc | Synthetic dna vectors and methods of use |
| WO2019191109A1 (en) * | 2018-03-28 | 2019-10-03 | The Board Of Trustees Of The Leland Stanford Junior University | Microrna inhibitors and their use in treating epiretinal membranes |
| EP3794126A1 (en) | 2018-05-15 | 2021-03-24 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
| EP3796893A1 (en) | 2018-05-23 | 2021-03-31 | Modernatx, Inc. | Delivery of dna |
| WO2019237391A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | CRISPR/Cas9 靶向敲除人 TXGP1 基因及其特异性 gRNA |
| WO2019237383A1 (zh) * | 2018-06-16 | 2019-12-19 | 深圳市博奥康生物科技有限公司 | 用于人 tnfsf18 基因编辑的修饰载体、其制备方法及应用 |
| CN112639110A (zh) * | 2018-06-22 | 2021-04-09 | 阿斯克肋匹奥生物制药公司 | 用于基因递送以在细胞内持续存在的载体 |
| EP3833766A1 (en) | 2018-08-09 | 2021-06-16 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| US20210310000A1 (en) * | 2018-08-17 | 2021-10-07 | City Of Hope | Compounds of chemically modified oligonucleotides and methods of use thereof |
| AU2019346655B2 (en) | 2018-09-28 | 2025-03-13 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| KR20210090619A (ko) * | 2018-11-09 | 2021-07-20 | 제너레이션 바이오 컴퍼니 | 대칭인 변형된 역말단반복을 포함하는 변형된 폐쇄형 DNA(ceDNA) |
| CN113412331A (zh) * | 2019-01-24 | 2021-09-17 | 世代生物公司 | 闭合端DNA(ceDNA)及其在减少与基因或核酸疗法相关的免疫应答的方法中的用途 |
| KR20210127935A (ko) * | 2019-02-15 | 2021-10-25 | 제너레이션 바이오 컴퍼니 | 폐쇄형 DNA(ceDNA) 생산에서의 Rep 단백질 활성의 변형 |
| WO2020181168A1 (en) * | 2019-03-06 | 2020-09-10 | Generation Bio Co. | Non-active lipid nanoparticles with non-viral, capsid free dna |
| MA55223A (fr) * | 2019-03-06 | 2022-01-12 | Generation Bio Co | Adn à extrémité fermée (cedna) et composés de modulation immunitaire |
| MA55313A (fr) | 2019-03-13 | 2022-01-19 | Generation Bio Co | Vecteurs d'adn non viraux et leurs utilisations pour exprimer des agents thérapeutiques du facteur viii |
| KR20210149702A (ko) * | 2019-03-13 | 2021-12-09 | 제너레이션 바이오 컴퍼니 | 비바이러스성 dna 벡터 및 페닐알라닌 히드록실라아제(pah) 치료제 발현을 위한 이의 용도 |
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