|
US337460A
(en)
|
|
1886-03-09 |
|
Fifth-wheel |
|
US337474A
(en)
|
|
1886-03-09 |
|
Leander l |
|
US233676A
(en)
|
|
1880-10-26 |
|
Combined cane-top and match-safe |
|
US337506A
(en)
|
|
1886-03-09 |
|
lagosse |
|
US233690A
(en)
|
|
1880-10-26 |
|
Water-conductor and joint |
|
US337514A
(en)
|
|
1886-03-09 |
|
William m |
|
US337481A
(en)
|
|
1886-03-09 |
|
Michael clune |
|
US337484A
(en)
|
|
1886-03-09 |
|
Solomon paul davis |
|
US101207A
(en)
|
|
1870-03-29 |
|
Improvement in screw and screw-driver |
|
US337508A
(en)
|
|
1886-03-09 |
|
James j |
|
US337492A
(en)
|
|
1886-03-09 |
|
Hadesty |
|
US337487A
(en)
|
|
1886-03-09 |
|
Cutter-head |
|
US337491A
(en)
|
|
1886-03-09 |
|
William h |
|
US337503A
(en)
|
|
1886-03-09 |
|
Tablet |
|
US337521A
(en)
|
|
1886-03-09 |
|
scaeeitt |
|
US337528A
(en)
|
|
1886-03-09 |
|
Waterproofing cloth |
|
US233710A
(en)
|
|
1880-10-26 |
|
theqdor steinway |
|
US337505A
(en)
|
|
1886-03-09 |
|
Chaeles la dow |
|
US337525A
(en)
|
|
1886-03-09 |
|
Agricultural implement |
|
US337490A
(en)
|
|
1886-03-09 |
|
Haebiette a |
|
US337516A
(en)
|
|
1886-03-09 |
|
Apparatus for burning gaseous fuel |
|
US337479A
(en)
|
|
1886-03-09 |
|
Steering-propeller |
|
US337497A
(en)
|
|
1886-03-09 |
|
Giles j |
|
US337488A
(en)
|
|
1886-03-09 |
|
Johannes evees |
|
US337526A
(en)
|
|
1886-03-09 |
|
serg-eant |
|
US337459A
(en)
|
|
1886-03-09 |
|
Apparatus for cleaning oil |
|
US337498A
(en)
|
|
1886-03-09 |
|
Alexander horne |
|
US337513A
(en)
|
|
1886-03-09 |
|
Method or process of making wire cables |
|
US233721A
(en)
|
|
1880-10-26 |
|
Mechanical musical instrument |
|
US337520A
(en)
|
|
1886-03-09 |
|
Feancis h |
|
US233717A
(en)
|
|
1880-10-26 |
|
Lrrhogftapher |
|
US337477A
(en)
|
|
1886-03-09 |
|
Hoeatio j |
|
US233722A
(en)
|
|
1880-10-26 |
|
One-wheel plow |
|
US337478A
(en)
|
|
1886-03-09 |
|
Calendar |
|
US2699808A
(en)
|
1944-10-06 |
1955-01-18 |
Mark W Lowe |
Apparatus for peeling tomatoes
|
|
US2699508A
(en)
|
1951-12-21 |
1955-01-11 |
Selectronics Inc |
Method of mounting and construction of mounting for low frequency piezoelectric crystals
|
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5591722A
(en)
|
1989-09-15 |
1997-01-07 |
Southern Research Institute |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
|
|
EP0497875B1
(en)
|
1989-10-24 |
2000-03-22 |
Isis Pharmaceuticals, Inc. |
2' modified oligonucleotides
|
|
US5670633A
(en)
|
1990-01-11 |
1997-09-23 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
GB9009980D0
(en)
|
1990-05-03 |
1990-06-27 |
Amersham Int Plc |
Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
|
|
DE69032425T2
(de)
|
1990-05-11 |
1998-11-26 |
Microprobe Corp., Bothell, Wash. |
Teststreifen zum Eintauchen für Nukleinsäure-Hybridisierungsassays und Verfahren zur kovalenten Immobilisierung von Oligonucleotiden
|
|
US6582908B2
(en)
|
1990-12-06 |
2003-06-24 |
Affymetrix, Inc. |
Oligonucleotides
|
|
ES2103918T3
(es)
|
1991-10-17 |
1997-10-01 |
Ciba Geigy Ag |
Nucleosidos biciclicos, oligonucleotidos, procedimiento para su obtencion y productos intermedios.
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
FR2687679B1
(fr)
|
1992-02-05 |
1994-10-28 |
Centre Nat Rech Scient |
Oligothionucleotides.
|
|
EP0577558A2
(de)
|
1992-07-01 |
1994-01-05 |
Ciba-Geigy Ag |
Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
|
|
EP0673559A1
(en)
|
1992-12-14 |
1995-09-27 |
Honeywell Inc. |
Motor system with individually controlled redundant windings
|
|
AU6449394A
(en)
|
1993-03-30 |
1994-10-24 |
Sterling Winthrop Inc. |
Acyclic nucleoside analogs and oligonucleotide sequences containing them
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
US5446137B1
(en)
|
1993-12-09 |
1998-10-06 |
Behringwerke Ag |
Oligonucleotides containing 4'-substituted nucleotides
|
|
US5519134A
(en)
|
1994-01-11 |
1996-05-21 |
Isis Pharmaceuticals, Inc. |
Pyrrolidine-containing monomers and oligomers
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US5597909A
(en)
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
|
US5656408A
(en)
|
1996-04-29 |
1997-08-12 |
Xerox Corporation |
Coated carrier particles
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
DE69829760T3
(de)
|
1997-09-12 |
2016-04-14 |
Exiqon A/S |
Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US20030228597A1
(en)
|
1998-04-13 |
2003-12-11 |
Cowsert Lex M. |
Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
BR0009884A
(pt)
|
1999-04-21 |
2002-01-08 |
American Home Prod |
Processos e composições para a inibição da função das sequências de polinucleotìdeos
|
|
AU776362B2
(en)
|
1999-05-04 |
2004-09-09 |
Roche Innovation Center Copenhagen A/S |
L-ribo-LNA analogues
|
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
|
EP1210363A2
(en)
|
1999-07-16 |
2002-06-05 |
Hyseq, Inc. |
Novel angiopoietin materials and methods
|
|
CN1433482A
(zh)
|
1999-12-09 |
2003-07-30 |
三共株式会社 |
高脂血症的治疗或预防剂的检验方法
|
|
EP1244667B1
(en)
|
1999-12-30 |
2006-04-05 |
K.U. Leuven Research & Development |
Cyclohexene nucleic acids
|
|
CA2450022A1
(en)
|
2001-06-08 |
2002-12-19 |
Sankyo Company, Limited |
Method of testing drug for treating or preventing diseases such as hyperlipemia
|
|
CA2452458A1
(en)
|
2001-07-03 |
2003-01-16 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
|
EP1451578B1
(en)
|
2001-11-16 |
2013-08-21 |
Genentech, Inc. |
Use of angptl3 antagonists for the treatment of liver diseases
|
|
WO2003100101A1
(en)
|
2002-05-28 |
2003-12-04 |
U.S. Genomics, Inc. |
Methods and apparati using single polymer analysis
|
|
WO2004011624A2
(en)
|
2002-07-31 |
2004-02-05 |
Nucleonics, Inc. |
Double stranded rna structures and constructs, and methods for generating and using the same
|
|
WO2004035765A2
(en)
|
2002-10-18 |
2004-04-29 |
Nucleonics, Inc. |
Double-stranded rna structures and constructs, and methods for generating and using the same
|
|
AU2003295387A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
EP1562971B1
(en)
|
2002-11-05 |
2014-02-12 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US7511131B2
(en)
|
2002-11-13 |
2009-03-31 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
US8090542B2
(en)
|
2002-11-14 |
2012-01-03 |
Dharmacon Inc. |
Functional and hyperfunctional siRNA
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US6673661B1
(en)
|
2002-12-20 |
2004-01-06 |
Taiwan Semiconductor Manufacturing Co., Ltd. |
Self-aligned method for forming dual gate thin film transistor (TFT) device
|
|
WO2004072046A2
(en)
*
|
2003-02-12 |
2004-08-26 |
Carex S.A. |
Quinoline derivatives and their use for modulation of lxr activity
|
|
US7598227B2
(en)
*
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
US20110086342A1
(en)
|
2003-08-22 |
2011-04-14 |
Nihon University |
Hepatocellular Carcinoma-Associated Gene
|
|
DK1661905T3
(da)
|
2003-08-28 |
2012-07-23 |
Takeshi Imanishi |
Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype
|
|
AU2004274021B2
(en)
|
2003-09-18 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
|
AU2005248147A1
(en)
|
2004-05-11 |
2005-12-08 |
Alphagen Co., Ltd. |
Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same
|
|
CA2569419A1
(en)
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
PT1771474E
(pt)
|
2004-07-20 |
2010-05-03 |
Genentech Inc |
Inibidores de proteína 4 do tipo angiopoietina, combinações e sua utilização
|
|
US7371384B2
(en)
|
2004-07-20 |
2008-05-13 |
Genentech, Inc. |
Compositions and methods of using angiopoietin-like 4 protein antibody
|
|
EP2397563A3
(en)
|
2004-09-17 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
|
US20080261905A1
(en)
|
2004-11-08 |
2008-10-23 |
K.U. Leuven Research And Development |
Modified Nucleosides for Rna Interference
|
|
DOP2007000015A
(es)
*
|
2006-01-20 |
2007-08-31 |
Quark Biotech Inc |
Usos terapéuticos de inhibidores de rtp801
|
|
CA2640171C
(en)
|
2006-01-27 |
2014-10-28 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
CA3044969A1
(en)
|
2006-05-05 |
2007-12-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gene expression
|
|
JP5441688B2
(ja)
|
2006-05-11 |
2014-03-12 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
５’修飾二環式核酸類似体
|
|
EP2418223A3
(en)
*
|
2006-06-12 |
2013-01-16 |
Emergent Product Development Seattle, LLC |
Single-chain multivalent binding proteins with effector function
|
|
US8101585B2
(en)
|
2006-08-04 |
2012-01-24 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of JNK proteins
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
CN101855241B
(zh)
|
2006-12-08 |
2013-11-06 |
莱克康制药公司 |
针对angptl3的单克隆抗体
|
|
WO2008101157A1
(en)
|
2007-02-15 |
2008-08-21 |
Isis Pharmaceuticals, Inc. |
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
|
|
EP2170917B1
(en)
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
ES2386492T3
(es)
|
2007-06-08 |
2012-08-21 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos carbocíclicos
|
|
CN101796062B
(zh)
|
2007-07-05 |
2014-07-30 |
Isis制药公司 |
6-双取代双环核酸类似物
|
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
CA2717618A1
(en)
|
2008-03-07 |
2009-09-11 |
National University Corporation University Of Toyama |
Homologous recombination method, cloning method, and kit
|
|
EP2108960A1
(en)
*
|
2008-04-07 |
2009-10-14 |
Arena Pharmaceuticals, Inc. |
Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
|
|
DK2356129T3
(da)
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
|
DK2361256T3
(da)
|
2008-09-24 |
2013-07-01 |
Isis Pharmaceuticals Inc |
Cyclohexenyl-nukleinsyreanaloger
|
|
EP2521556B1
(en)
|
2010-01-08 |
2018-05-30 |
Ionis Pharmaceuticals, Inc. |
Modulation of angiopoietin-like 3 expression
|
|
EP2601204B1
(en)
|
2010-04-28 |
2016-09-07 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
CN103890000B
(zh)
*
|
2011-06-21 |
2017-09-01 |
阿尔尼拉姆医药品有限公司 |
血管生成素样3(ANGPTL3)iRNA组合物及其使用方法
|
|
WO2013142571A2
(en)
*
|
2012-03-20 |
2013-09-26 |
Cornell University |
Assays for the identification of compounds that modulate lipid homeostasis
|
|
US9984408B1
(en)
|
2012-05-30 |
2018-05-29 |
Amazon Technologies, Inc. |
Method, medium, and system for live video cooperative shopping
|
|
CN105814204B
(zh)
|
2013-12-24 |
2020-04-28 |
Ionis制药公司 |
促血管生成素样3表达的调节
|
|
ES2844593T3
(es)
*
|
2014-05-01 |
2021-07-22 |
Ionis Pharmaceuticals Inc |
Composiciones y procedimientos para modular la expresión de la angiopoyetina de tipo 3
|