JP6643996B2 - アンジオポエチン様３発現の調節 - Google Patents

アンジオポエチン様３発現の調節 Download PDF

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JP6643996B2
JP6643996B2 JP2016542739A JP2016542739A JP6643996B2 JP 6643996 B2 JP6643996 B2 JP 6643996B2 JP 2016542739 A JP2016542739 A JP 2016542739A JP 2016542739 A JP2016542739 A JP 2016542739A JP 6643996 B2 JP6643996 B2 JP 6643996B2
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certain embodiments
antisense
modified
compound
angptl3
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JP2017505116A (ja
JP2017505116A5 (enExample
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フレアー，スーザン・エム
グラハム，マーク・ジェイ
クルック，ロザンヌ・エム
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016542739A 2013-12-24 2014-12-24 アンジオポエチン様３発現の調節 Expired - Fee Related JP6643996B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361920652P 2013-12-24 2013-12-24
US61/920,652 2013-12-24
PCT/US2014/072303 WO2015100394A1 (en) 2013-12-24 2014-12-24 Modulation of angiopoietin-like 3 expression

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JP2020000628A Division JP2020072713A (ja) 2013-12-24 2020-01-07 アンジオポエチン様３発現の調節

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JP2017505116A JP2017505116A (ja) 2017-02-16
JP2017505116A5 JP2017505116A5 (enExample) 2018-02-08
JP6643996B2 true JP6643996B2 (ja) 2020-02-12

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JP2020000628A Pending JP2020072713A (ja) 2013-12-24 2020-01-07 アンジオポエチン様３発現の調節

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US (3) US20170037409A1 (enExample)
EP (2) EP3087183B1 (enExample)
JP (2) JP6643996B2 (enExample)
KR (2) KR102298476B1 (enExample)
CN (3) CN111394355A (enExample)
AU (2) AU2014369900B2 (enExample)
BR (1) BR112016013473A2 (enExample)
CA (1) CA2931510A1 (enExample)
DK (1) DK3087183T3 (enExample)
ES (1) ES2830257T3 (enExample)
HU (1) HUE052243T2 (enExample)
IL (2) IL245707B (enExample)
MX (1) MX383753B (enExample)
NZ (1) NZ720286A (enExample)
PL (1) PL3087183T3 (enExample)
PT (1) PT3087183T (enExample)
RU (1) RU2706964C2 (enExample)
SI (1) SI3087183T1 (enExample)
WO (1) WO2015100394A1 (enExample)

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MA44234B1 (fr) * 2016-02-17 2023-10-31 Regeneron Pharma Procédés de traitement ou de prévention de l'athérosclérose par administration d'un inhibiteur d'angptl3
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WO2019105435A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
JP7261494B2 (ja) 2017-12-01 2023-04-20 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
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KR102756073B1 (ko) 2017-12-01 2025-01-20 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 이중-가닥 올리고뉴클레오티드, 조성물 및 이중-가닥 올리고뉴클레오티드를 포함하는 접합체, 그의 제조 방법 및 그의 용도
WO2019105419A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
HRP20250408T1 (hr) 2017-12-29 2025-06-06 Suzhou Ribo Life Science Co., Ltd. Kojugati i njihova priprema i uporaba
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CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
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WO2020099482A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl 3 oligonucleotides influencing the regulation of the fatty acid metabolism
CN111973617A (zh) * 2019-05-23 2020-11-24 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
TWI870563B (zh) * 2020-03-18 2025-01-21 美商戴瑟納製藥股份有限公司 用於抑制angptl3表現之組合物及方法
EP4132591A4 (en) 2020-04-09 2024-04-24 Verve Therapeutics, Inc. Base editing of pcsk9 and methods of using same for treatment of disease
JP2023546103A (ja) * 2020-10-16 2023-11-01 サノフイ Ａｎｇｐｔｌ３を阻害するための新規のｒｎａ組成物および方法
CN113956345B (zh) * 2021-09-10 2024-04-23 北京大学 Angpt4蛋白及其编码基因在调控心脏损伤后的修复与再生能力中的应用
EP4453210A1 (en) 2021-12-22 2024-10-30 Regeneron Pharmaceuticals, Inc. Treatment of kidney diseases with angiopoietin like 3 (angptl3) inhibitors
WO2023134705A1 (zh) * 2022-01-11 2023-07-20 上海金中锘美生物医药科技有限公司 抑制angptl3表达的rna干扰剂及其用途
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CN120112639A (zh) * 2022-08-22 2025-06-06 箭头药业股份有限公司 Angptl3相关疾病和病症的治疗方法
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