UY30097A1 - Usos terapeuticos de inhibidores de rtp801 - Google Patents
Usos terapeuticos de inhibidores de rtp801Info
- Publication number
- UY30097A1 UY30097A1 UY30097A UY30097A UY30097A1 UY 30097 A1 UY30097 A1 UY 30097A1 UY 30097 A UY30097 A UY 30097A UY 30097 A UY30097 A UY 30097A UY 30097 A1 UY30097 A1 UY 30097A1
- Authority
- UY
- Uruguay
- Prior art keywords
- therapeutic uses
- rtp801
- rtp801 inhibitors
- inhibitors
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Abstract
La presente invención proporciona moléculas, composiciones, procedimientos y usos novedosos para tratar trastornos microvasculares, enfermedades oculares, afecciones respiratorias y trastornos auditivos que se basan en la inhibición del gen y/o proteína RTP801.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76058606P | 2006-01-20 | 2006-01-20 | |
US79690106P | 2006-05-01 | 2006-05-01 | |
US85100006P | 2006-10-10 | 2006-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY30097A1 true UY30097A1 (es) | 2007-08-31 |
Family
ID=38288268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY30097A UY30097A1 (es) | 2006-01-20 | 2007-01-17 | Usos terapeuticos de inhibidores de rtp801 |
Country Status (19)
Country | Link |
---|---|
US (2) | US8067570B2 (es) |
EP (2) | EP1984003A4 (es) |
JP (1) | JP2009523814A (es) |
KR (1) | KR20080085887A (es) |
AR (1) | AR059093A1 (es) |
AU (1) | AU2007207479B2 (es) |
BR (1) | BRPI0707160A2 (es) |
CA (1) | CA2635723A1 (es) |
DO (1) | DOP2007000015A (es) |
GT (1) | GT200700004A (es) |
IL (2) | IL192880A0 (es) |
MX (1) | MX2008009355A (es) |
NL (1) | NL2000439C2 (es) |
PE (1) | PE20071242A1 (es) |
SG (1) | SG179410A1 (es) |
TW (1) | TW200806325A (es) |
UY (1) | UY30097A1 (es) |
WO (1) | WO2007084684A2 (es) |
ZA (1) | ZA200806150B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1857547B2 (en) | 2002-08-05 | 2020-12-02 | Silence Therapeutics GmbH | Further novel forms of interfering RNA molecules |
KR101094617B1 (ko) * | 2004-08-16 | 2011-12-15 | 사일런스 테라퓨틱스 아게 | 알티피801 억제제의 치료적 용도 |
US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
DOP2007000015A (es) | 2006-01-20 | 2007-08-31 | Quark Biotech Inc | Usos terapéuticos de inhibidores de rtp801 |
WO2008046757A1 (en) | 2006-10-19 | 2008-04-24 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
MX2009003939A (es) | 2006-10-19 | 2009-05-11 | Hoffmann La Roche | Derivados de imidazolona e imidazolidinona como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 para diabetes. |
WO2009044392A2 (en) * | 2007-10-03 | 2009-04-09 | Quark Pharmaceuticals, Inc. | Novel sirna structures |
US8614311B2 (en) | 2007-12-12 | 2013-12-24 | Quark Pharmaceuticals, Inc. | RTP801L siRNA compounds and methods of use thereof |
MX2010010303A (es) * | 2008-03-20 | 2010-10-20 | Quark Pharmaceuticals Inc | Nuevos compuestos de acido ribonucleico de pequeña interferencia para inhibir rtp801. |
EP2293800B1 (en) * | 2008-06-06 | 2016-10-05 | Quark Pharmaceuticals, Inc. | Compositions and methods for treatment of ear disorders |
US9433684B2 (en) | 2008-08-19 | 2016-09-06 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
EP2440214A4 (en) * | 2009-06-08 | 2013-07-31 | Quark Pharmaceuticals Inc | METHODS OF TREATING CHRONIC RENAL DISEASE |
WO2011035065A1 (en) | 2009-09-17 | 2011-03-24 | Nektar Therapeutics | Monoconjugated chitosans as delivery agents for small interfering nucleic acids |
WO2011066475A1 (en) | 2009-11-26 | 2011-06-03 | Quark Pharmaceuticals, Inc. | Sirna compounds comprising terminal substitutions |
EP2510098B1 (en) | 2009-12-09 | 2015-02-11 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the cns |
CN103298939A (zh) | 2010-12-06 | 2013-09-11 | 夸克医药公司 | 包含位置修饰的双链寡核苷酸化合物 |
EP2683825B1 (en) * | 2011-03-11 | 2017-01-04 | Sarissa Inc. | Methods of treating cancer by inhibition of dna repair proteins |
WO2012145427A1 (en) | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
EP2776565A1 (en) | 2011-11-08 | 2014-09-17 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
CA2880290C (en) | 2012-09-12 | 2020-10-27 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules targeting p53 and methods of use thereof |
CN111394355A (zh) * | 2013-12-24 | 2020-07-10 | Ionis制药公司 | 促血管生成素样3表达的调节 |
EP3548005A4 (en) | 2016-11-29 | 2020-06-17 | Puretech Health LLC | EXOSOMES FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US4959217A (en) | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
US4925678A (en) | 1987-04-01 | 1990-05-15 | Ranney David F | Endothelial envelopment drug carriers |
US5080646A (en) | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5270030A (en) | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5225347A (en) | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Therapeutic ribozyme compositions and expression vectors |
US5218088A (en) | 1989-11-02 | 1993-06-08 | Purdue Research Foundation | Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates |
US5167616A (en) | 1989-12-14 | 1992-12-01 | Alza Corporation | Iontophoretic delivery method |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5225182A (en) | 1991-10-31 | 1993-07-06 | Sharma Yash P | Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system |
US6372249B1 (en) | 1991-12-16 | 2002-04-16 | Baylor College Of Medicine | Senscent cell-derived inhibitors of DNA synthesis |
EP1044987B1 (en) | 1991-12-24 | 2006-02-15 | Isis Pharmaceuticals, Inc. | Gapped 2'-modified oligonucleotides |
JPH08500481A (ja) | 1992-05-11 | 1996-01-23 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | ウイルスの複製を阻害するための方法および薬剤 |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
EP1709970A1 (en) | 1995-04-27 | 2006-10-11 | Abgenix, Inc. | Human antibodies against EGFR, derived from immunized xenomice |
CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
BRPI9809391B8 (pt) | 1997-04-14 | 2021-05-25 | Amgen Res Munich Gmbh | processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
EP1009753B1 (en) | 1997-08-21 | 2005-04-20 | Quark Biotech, Inc. | Hypoxia-regulated genes |
US20030104973A1 (en) | 1997-08-21 | 2003-06-05 | Quark Biotech, Inc. | Hypoxia-regulated genes |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
DE19816395A1 (de) | 1998-04-03 | 1999-10-07 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Ovar-Normalgewebe |
US6228585B1 (en) | 1998-09-04 | 2001-05-08 | Washington University | Gene markers for chronic mucosal injury |
US6867289B1 (en) | 1998-10-26 | 2005-03-15 | Board Of Regents, The University Of Texas Systems | Thio-modified aptamer synthetic methods and compositions |
WO2000044914A1 (en) | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
WO2000077022A1 (en) | 1999-06-11 | 2000-12-21 | Human Genome Sciences, Inc. | 50 human secreted proteins |
AU4074500A (en) | 1999-04-09 | 2000-11-14 | Human Genome Sciences, Inc. | 49 human secreted proteins |
WO2001005998A1 (en) | 1999-07-16 | 2001-01-25 | Human Genome Sciences, Inc. | Follistatin-3 |
AU7680300A (en) | 1999-08-18 | 2001-03-13 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Human dna sequences |
GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
JP2003526367A (ja) | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Rna干渉の方法とrna干渉組成物 |
US20030084471A1 (en) | 2000-03-16 | 2003-05-01 | David Beach | Methods and compositions for RNA interference |
AU4592601A (en) | 2000-03-21 | 2001-10-03 | Millennium Predictive Medicine | Novel genes, compositions, kits, and method for identification, assessment, prevention, and therapy of ovarian cancer |
PT1309726E (pt) | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
AU2001249642A1 (en) | 2000-04-06 | 2001-10-23 | Genetics Institute, Llc | Polynucleotides encoding novel secreted proteins |
US6673545B2 (en) | 2000-07-28 | 2004-01-06 | Incyte Corporation | Prostate cancer markers |
US6727066B2 (en) | 2000-07-28 | 2004-04-27 | Incyte Corporation | Genes expressed in treated human C3A liver cell cultures |
CA2425827A1 (en) | 2000-10-12 | 2002-04-18 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
US6673549B1 (en) | 2000-10-12 | 2004-01-06 | Incyte Corporation | Genes expressed in C3A liver cell cultures treated with steroids |
US20020137077A1 (en) | 2000-10-25 | 2002-09-26 | Hopkins Christopher M. | Genes regulated in activated T cells |
DK2813582T3 (en) | 2000-12-01 | 2017-07-31 | Max-Planck-Gesellschaft Zur Förderung Der Wss E V | Small RNA molecules that mediate RNA interference |
AU2002220920A1 (en) | 2000-12-08 | 2002-06-18 | Oxford Biomedica (Uk) Limited | Method for identification of genes involved in specific diseases |
CA2433680A1 (en) | 2000-12-28 | 2002-08-01 | Gregory M Arndt | Double-stranded rna-mediated gene suppression |
US20030165864A1 (en) | 2001-01-16 | 2003-09-04 | Lasek Amy W. | Genes regulated by DNA methylation in tumor cells |
US20040019001A1 (en) | 2002-02-20 | 2004-01-29 | Mcswiggen James A. | RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA |
US7125663B2 (en) | 2001-06-13 | 2006-10-24 | Millenium Pharmaceuticals, Inc. | Genes, compositions, kits and methods for identification, assessment, prevention, and therapy of cervical cancer |
WO2003010205A1 (en) * | 2001-07-26 | 2003-02-06 | Duke University Medical Center | Genes induced by hypoxia |
US20040063654A1 (en) | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
US20030166282A1 (en) | 2002-02-01 | 2003-09-04 | David Brown | High potency siRNAS for reducing the expression of target genes |
AU2003207708A1 (en) | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
JP2003259877A (ja) | 2002-03-11 | 2003-09-16 | Sumitomo Pharmaceut Co Ltd | 肝線維症疾患マーカーおよびその利用 |
WO2003101283A2 (en) | 2002-06-04 | 2003-12-11 | Incyte Corporation | Diagnostics markers for lung cancer |
EP1857547B2 (en) * | 2002-08-05 | 2020-12-02 | Silence Therapeutics GmbH | Further novel forms of interfering RNA molecules |
JP2004121218A (ja) | 2002-08-06 | 2004-04-22 | Jenokkusu Soyaku Kenkyusho:Kk | 気管支喘息または慢性閉塞性肺疾患の検査方法 |
EP2311980A1 (en) | 2002-08-20 | 2011-04-20 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer |
JP2006516089A (ja) | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
EP1578996A4 (en) | 2002-10-18 | 2007-12-19 | Genentech Inc | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING TUMORS |
MXPA05004134A (es) * | 2002-10-18 | 2005-10-05 | Atugen Ag | Factor involucrado en la metastasis y usos del mismo. |
WO2004039956A2 (en) | 2002-10-29 | 2004-05-13 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
US9150605B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2′-modified nucleosides for use in gene modulation |
EP2305813A3 (en) | 2002-11-14 | 2012-03-28 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
WO2004045545A2 (en) | 2002-11-18 | 2004-06-03 | Fox Chase Cancer Center | Compositions and methods for the treatment of cancer, screening of putative anti-cancer compounds, and assessing cancer progression |
ES2339113T3 (es) | 2003-02-21 | 2010-05-17 | University Of Utah Research Foundation | Plasmido vegf inducible por la hipoxia para una enfermedad isquemica. |
EP2233926A3 (en) | 2003-04-01 | 2011-01-12 | The Johns Hopkins University | Breast Endothelial Cell Expression Patterns |
ES2712695T3 (es) | 2003-06-02 | 2019-05-14 | Univ Massachusetts | Métodos y composiciones para controlar la eficacia de la silenciación del ARN |
WO2005016000A1 (en) | 2003-08-05 | 2005-02-24 | Avalon Pharmaceuticals | Derivatives of cyclic quinone and uses thereof |
WO2005062937A2 (en) | 2003-12-22 | 2005-07-14 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna |
KR101094617B1 (ko) | 2004-08-16 | 2011-12-15 | 사일런스 테라퓨틱스 아게 | 알티피801 억제제의 치료적 용도 |
AU2005288522B2 (en) * | 2004-09-28 | 2012-06-28 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
DOP2007000015A (es) | 2006-01-20 | 2007-08-31 | Quark Biotech Inc | Usos terapéuticos de inhibidores de rtp801 |
WO2007087451A2 (en) | 2006-01-25 | 2007-08-02 | University Of Massachusetts | Compositions and methods for enhancing discriminatory rna interference |
US7723052B2 (en) | 2006-05-11 | 2010-05-25 | Quark Pharmaceuticals, Inc. | Screening systems utilizing RTP801 |
EP2026843A4 (en) | 2006-06-09 | 2011-06-22 | Quark Pharmaceuticals Inc | THERAPEUTIC USES OF RTP801L INHIBITORS |
EP2137205A2 (en) | 2007-02-26 | 2009-12-30 | Quark Pharmaceuticals, Inc. | Inhibitors of rtp801 and their use in disease treatment |
-
2007
- 2007-01-17 DO DO2007000015A patent/DOP2007000015A/es unknown
- 2007-01-17 NL NL2000439A patent/NL2000439C2/nl not_active IP Right Cessation
- 2007-01-17 UY UY30097A patent/UY30097A1/es not_active Application Discontinuation
- 2007-01-18 EP EP07718224A patent/EP1984003A4/en not_active Withdrawn
- 2007-01-18 CA CA002635723A patent/CA2635723A1/en not_active Abandoned
- 2007-01-18 AU AU2007207479A patent/AU2007207479B2/en not_active Ceased
- 2007-01-18 KR KR1020087017705A patent/KR20080085887A/ko not_active Application Discontinuation
- 2007-01-18 EP EP11172942.2A patent/EP2402443A3/en not_active Withdrawn
- 2007-01-18 BR BRPI0707160-4A patent/BRPI0707160A2/pt not_active IP Right Cessation
- 2007-01-18 MX MX2008009355A patent/MX2008009355A/es not_active Application Discontinuation
- 2007-01-18 US US11/655,636 patent/US8067570B2/en not_active Expired - Fee Related
- 2007-01-18 WO PCT/US2007/001468 patent/WO2007084684A2/en active Application Filing
- 2007-01-18 SG SG2012013595A patent/SG179410A1/en unknown
- 2007-01-18 JP JP2008551422A patent/JP2009523814A/ja active Pending
- 2007-01-19 AR ARP070100243A patent/AR059093A1/es unknown
- 2007-01-19 PE PE2007000059A patent/PE20071242A1/es not_active Application Discontinuation
- 2007-01-19 TW TW096102139A patent/TW200806325A/zh unknown
- 2007-01-19 GT GT200700004A patent/GT200700004A/es unknown
-
2008
- 2008-07-15 ZA ZA2008/06150A patent/ZA200806150B/en unknown
- 2008-07-17 IL IL192880A patent/IL192880A0/en unknown
-
2011
- 2011-03-21 IL IL211835A patent/IL211835A0/en unknown
- 2011-09-15 US US13/233,907 patent/US9056903B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20080085887A (ko) | 2008-09-24 |
WO2007084684A3 (en) | 2008-03-20 |
NL2000439A1 (nl) | 2007-07-23 |
US20100272722A1 (en) | 2010-10-28 |
BRPI0707160A2 (pt) | 2011-04-26 |
PE20071242A1 (es) | 2008-01-30 |
NL2000439C2 (nl) | 2009-03-16 |
MX2008009355A (es) | 2008-12-15 |
EP1984003A4 (en) | 2011-01-05 |
JP2009523814A (ja) | 2009-06-25 |
US20120156208A1 (en) | 2012-06-21 |
EP1984003A2 (en) | 2008-10-29 |
EP2402443A3 (en) | 2015-10-07 |
AU2007207479A1 (en) | 2007-07-26 |
AU2007207479B2 (en) | 2012-05-10 |
ZA200806150B (en) | 2010-11-24 |
EP2402443A2 (en) | 2012-01-04 |
AR059093A1 (es) | 2008-03-12 |
IL192880A0 (en) | 2009-02-11 |
TW200806325A (en) | 2008-02-01 |
US8067570B2 (en) | 2011-11-29 |
WO2007084684A2 (en) | 2007-07-26 |
CA2635723A1 (en) | 2007-07-26 |
GT200700004A (es) | 2007-12-03 |
SG179410A1 (en) | 2012-04-27 |
IL211835A0 (en) | 2011-05-31 |
DOP2007000015A (es) | 2007-08-31 |
US9056903B2 (en) | 2015-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY30097A1 (es) | Usos terapeuticos de inhibidores de rtp801 | |
EA200700333A1 (ru) | Терапевтические применения ингибиторов rtp801 | |
WO2007141796A3 (en) | Therapeutic uses of inhibitors of rtp801l | |
CY1119766T1 (el) | Νεοι ρυθμιστες κινασης βενζοπυρανιου | |
EA201071245A1 (ru) | Новые терапевтические подходы для лечения болезни альцгеймера и связанных нарушений посредством модулирования реакции клеток на стресс | |
CL2020000483A1 (es) | Nuevos usos de derivados de piperidinil–indol. | |
MA40240A (fr) | Composés hétéroaryle d'inhibition de la kinase | |
EA200901166A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr 119 | |
EA201071243A1 (ru) | Комбинированные композиции для лечения болезни альцгеймера и родственных заболеваний зонизамидом и акампросатом | |
ECSP088852A (es) | Azolopirimidinas como inhibidores de la actividad canabinoidea 1 | |
EA201890394A1 (ru) | КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ ТРАНСТИРЕТИНА (TTR) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ИЛИ ПРЕДУПРЕЖДЕНИЯ АССОЦИИРОВАННЫХ С TTR ЗАБОЛЕВАНИЙ | |
EA200901032A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
TN2010000122A1 (en) | Compounds and compositions as modulators of gpr119 activity | |
EA201000016A1 (ru) | Способы и композиции для лечения рака, опухолей и нарушений, связанных с опухолями | |
MA32393B1 (fr) | Composés et compositions servant d'inhibiteurs de kinases | |
MY172151A (en) | Certain chemical entities, compositions and methods | |
EA201170349A1 (ru) | Модуляторы mif | |
BRPI0820668A2 (pt) | Derivados de oxindol substituídos por 5-halogênio e seu uso para tratar doenças dependentes de vasopressina | |
EP2563794A4 (en) | INHIBITORS OF TYROSINE KINASE PROTEIN ACTIVITY AND THEIR APPLICATIONS TO THE TREATMENT OF OPHTHALMIC DISORDERS | |
TW200740808A (en) | Inhibiteurs de proteines kinases | |
NO20083751L (no) | Metoder for behandling av kognitive og andre sykdommer | |
BR112022009710A2 (pt) | Terapia de combinação compreendendo um inibidor de alk2 e um inibidor de jak2 | |
MX2020011826A (es) | Composiciones de combinacion que comprenden compuestos de bisfluoroalquil-1,4-benzodiazepinona y metodos de uso de las mismas. | |
ECSP077260A (es) | Usos terapéuticos de los inhibidores del rtp801 | |
UA92465C2 (ru) | Терапевтические применения ингибиторов rtp801 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20170526 |