DK3087183T3 - Modulation af angiopoietin-3-lignende ekspression - Google Patents

Modulation af angiopoietin-3-lignende ekspression Download PDF

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Publication number
DK3087183T3
DK3087183T3 DK14874081.4T DK14874081T DK3087183T3 DK 3087183 T3 DK3087183 T3 DK 3087183T3 DK 14874081 T DK14874081 T DK 14874081T DK 3087183 T3 DK3087183 T3 DK 3087183T3
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angiopoietin
modulation
expression
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DK14874081.4T
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English (en)
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Susan M Freier
Mark J Graham
Rosanne M Crooke
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Ionis Pharmaceuticals Inc
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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DK14874081.4T 2013-12-24 2014-12-24 Modulation af angiopoietin-3-lignende ekspression DK3087183T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361920652P 2013-12-24 2013-12-24
PCT/US2014/072303 WO2015100394A1 (en) 2013-12-24 2014-12-24 Modulation of angiopoietin-like 3 expression

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DK3087183T3 true DK3087183T3 (da) 2020-09-14

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US (3) US20170037409A1 (da)
EP (2) EP3087183B1 (da)
JP (2) JP6643996B2 (da)
KR (2) KR102198082B1 (da)
CN (3) CN105814204B (da)
AU (2) AU2014369900B2 (da)
BR (1) BR112016013473A2 (da)
CA (1) CA2931510A1 (da)
DK (1) DK3087183T3 (da)
ES (1) ES2830257T3 (da)
HU (1) HUE052243T2 (da)
IL (2) IL245707B (da)
MX (1) MX2016008462A (da)
NZ (1) NZ720286A (da)
PL (1) PL3087183T3 (da)
PT (1) PT3087183T (da)
RU (1) RU2706964C2 (da)
SI (1) SI3087183T1 (da)
WO (1) WO2015100394A1 (da)

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WO2020099482A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl 3 oligonucleotides influencing the regulation of the fatty acid metabolism
WO2020099525A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Oligonucleotides influencing the regulation of the fatty acid metabolism
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JP7457832B2 (ja) * 2020-04-09 2024-03-28 ヴァーヴ・セラピューティクス，インコーポレーテッド Ｐｃｓｋ９の塩基編集および疾患の処置のためにこれを使用する方法
JP2023546103A (ja) * 2020-10-16 2023-11-01 サノフイ Ａｎｇｐｔｌ３を阻害するための新規のｒｎａ組成物および方法
CN113956345B (zh) * 2021-09-10 2024-04-23 北京大学 Angpt4蛋白及其编码基因在调控心脏损伤后的修复与再生能力中的应用
US20230193271A1 (en) 2021-12-22 2023-06-22 Regeneron Pharmaceuticals, Inc. Treatment Of Kidney Diseases With Angiopoietin Like 3 (ANGPTL3) Inhibitors
WO2023134705A1 (zh) * 2022-01-11 2023-07-20 上海金中锘美生物医药科技有限公司 抑制angptl3表达的rna干扰剂及其用途

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