DK3022217T3 - Sammensætninger til modulering af tau-ekspression - Google Patents

Sammensætninger til modulering af tau-ekspression Download PDF

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Publication number
DK3022217T3
DK3022217T3 DK14826839.4T DK14826839T DK3022217T3 DK 3022217 T3 DK3022217 T3 DK 3022217T3 DK 14826839 T DK14826839 T DK 14826839T DK 3022217 T3 DK3022217 T3 DK 3022217T3
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modulation
compositions
tau expression
tau
expression
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DK14826839.4T
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English (en)
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Holly Kordasiewicz
Eric E Swayze
Susan M Freier
Huynh-Hoa Bui
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Biogen Ma Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

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  • Neurology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
DK14826839.4T 2013-07-19 2014-07-21 Sammensætninger til modulering af tau-ekspression DK3022217T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361856551P 2013-07-19 2013-07-19
US201361879621P 2013-09-18 2013-09-18
US201361885371P 2013-10-01 2013-10-01
US201462014486P 2014-06-19 2014-06-19
PCT/US2014/047486 WO2015010135A2 (en) 2013-07-19 2014-07-21 Compositions for modulating tau expression

Publications (1)

Publication Number Publication Date
DK3022217T3 true DK3022217T3 (da) 2021-06-28

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Application Number Title Priority Date Filing Date
DK14826839.4T DK3022217T3 (da) 2013-07-19 2014-07-21 Sammensætninger til modulering af tau-ekspression

Country Status (25)

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US (4) US9683235B2 (da)
EP (2) EP3022217B1 (da)
JP (4) JP6684707B2 (da)
KR (4) KR102273926B1 (da)
CN (2) CN108064227B (da)
AU (2) AU2014290395B2 (da)
BR (1) BR112016000654B1 (da)
CA (2) CA2918600C (da)
CY (1) CY1124292T1 (da)
DK (1) DK3022217T3 (da)
ES (1) ES2871533T3 (da)
HK (1) HK1223626A1 (da)
HR (1) HRP20211051T1 (da)
HU (1) HUE055144T2 (da)
IL (4) IL279572B2 (da)
LT (1) LT3022217T (da)
MX (2) MX2016000782A (da)
NZ (2) NZ715828A (da)
PL (1) PL3022217T3 (da)
PT (1) PT3022217T (da)
RS (1) RS62054B1 (da)
RU (1) RU2735551C2 (da)
SI (1) SI3022217T1 (da)
TW (4) TW202246503A (da)
WO (1) WO2015010135A2 (da)

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