KR102526525B1 - 타우 발현 조절 조성물 - Google Patents
타우 발현 조절 조성물 Download PDFInfo
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- KR102526525B1 KR102526525B1 KR1020227025324A KR20227025324A KR102526525B1 KR 102526525 B1 KR102526525 B1 KR 102526525B1 KR 1020227025324 A KR1020227025324 A KR 1020227025324A KR 20227025324 A KR20227025324 A KR 20227025324A KR 102526525 B1 KR102526525 B1 KR 102526525B1
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- tau
- wing segment
- modified
- certain embodiments
- antisense
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Abstract
타우 mRNA 및 단백질의 발현을 감소시키기 위한 방법 및 안티센스 화합물이 본원에서 제공된다. 본원의 방법, 화합물, 및 조성물은 타우 연관된 질환, 장애, 및 병태를 치료, 예방, 및 개선하는데 유용하다.
Description
서열목록
본 발명은 전자 형식으로 서열목록과 함께 출원된다. 서열목록은 그 크기가 916 Kb인 파일명 BIOL0227WOSEQ_ST25.txt (2014년 6월 17일에 만들어짐)로서 제공되어 있다. 상기 서열목록의 전자 형식의 정보는 본 명세서에 그의 전문이 참고로 편입된다.
기술 분야
동물에서 타우 mRNA 및 단백질의 발현을 감소시키기 위한 방법, 화합물, 및 조성물이 본원에서 제공된다. 그러한 방법은 동물에서 타우 발현을 억제함으로써 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 및 드라벳 증후군을 포함하는 신경퇴행성 질병을 치료, 예방, 또는 개선하는데 유용하다.
타우의 1차 기능은 유사분열, 세포질분열, 및 소포 이동과 관련된 세포골격의 중요한 구조적 성분인 미세소관에 연결하고 이를 안정시키는 것이다. 타우는 다수 조직에서 발견되나, 뉴런의 축삭에 특히 많다. 인간에게는 엑손 2, 3, 및 10의 대안적 스플라이싱에 의하여 생성된, 6개의 타우 이소형이 있다. 단백질의 N 말단에서의 엑손 2, 3의 스플라이싱은 0, 1, 또는 2개의 29 아미노산 산성 도메인의 포함을 야기하고, 이는 각각 0N, 1N, 또는 2N 타우라고 지칭된다. 타우 기능에 대한 이러한 도메인의 영향은 완전히 명백하지는 않으나, 원형질막과 상호작용하는 역할을 할 수 있다. C 말단에서의 엑손 10의 포함은 엑손 10에 의하여 암호화된 미세소관 연결 도메인의 포함을 야기한다. 타우의 다른 곳에서 3개의 미세소관 연결 도메인이 있으므로, 이러한 타우 이소형 (엑손 10 포함)은 4R 타우라고 지칭되며, 여기서 'R'은 미세소관 연결 도메인의 반복 수를 나타낸다. 엑손 10이 없는 타우는 3R 타우라 불리운다. 더욱 많은 미세소관 연결 도메인 (3R과 비교한 4R)은 미세소관에 대한 연결을 증가시키므로, 4R 타우는 미세소관 연결 및 조립을 뚜렷하게 증가시킬 것이다. 3R/4R 타우 비율은 3R 타우를 독점적으로 발현하는 태아 조직 및 대략적으로 평형한 수준의 3R/4R 타우를 발현하는 성체 인간 조직과 함께 발달적으로 조절된다. 3R/4R 타우의 표준 비율로부터의 편차는 신경퇴행성 FTD 타우병증의 특성이다. 성체 동물에서 후기 단계에서의 3R/4R 타우 비율의 변화가 어떻게 타우 발병에 영향을 줄 것인지에 대한 것은 알려져 있지 않다.
세린-트레오닌 유도 인산화는 타우의 미세소관 연결 능력을 조절한다. 과인산화는 미세소관으로부터의 타우 분리를 촉진한다. 타우의 다른 번역-후 변형이 기술되어 왔으나; 이러한 것들의 중요성은 명백하지 않다. 타우의 인산화는 또한 태아 조직에서 더 높은 인산화 및 성체에서 훨씬 낮은 인산화와 함께 발달적으로 조절된다. 신경퇴행성 장애의 한 특성은 비정상적으로 증가된 타우 인산화이다.
미세소관 네트워크는 세포의 모폴로지를 유지시키고 이송 기작을 작동시키는데 필요한 구조적 통합을 포함하는, 세포내 많은 중요 과정과 연관된다. 타우의 미세소관으로의 연결이 미세소관을 안정시키므로, 타우는 이러한 과정 중 일부의 중요 매개자일 가능성이 있으며, 신경 퇴행성 질환에서 정상 타우의 파괴는 이러한 중요 세포 과정의 일부를 파괴할 수 있다.
타우가 신경퇴행성 증후군에서 중요할 수 있다는 초기 지표 중 하나는, 타우가 알츠하이머 질환에서 신경섬유 포함물의 중요 구성성분이라는 것에 대한 인식이다. 사실, 신경섬유 포함물은 과인산화된 타우 단백질의 군체이다. 플라크를 함유하는 아밀로이드 베타와 함께, 신경섬유 포함물은 알츠하이머 질환의 특징이고, 인지 장애와 뚜렷하게 연관된다. AD에서의 타우 누적 중 95%는 뉴런 과정에서 발견되고, 신경염성 이영양증으로 불리운다. 이러한 미세소관 연관 단백질이 미세소관으로부터 유리되고 단백질의 누적을 형성하는 과정 및 이것이 어떻게 뉴런 독성과 관련있는지에 대한 자세한 이해는 없는 상황이다.
뉴런 타우 포함물은 알츠하이머 질환 뿐만 아니라, 전두측두엽 치매 (FTD), PSP, 및 CBD의 병리학적 특성이다. 타우 및 신경퇴행 사이의 연관은 타우 유전자의 돌연변이가 FTD의 서브세트(subset)를 야기한다는 발견에 의하여 공고해졌다. 이러한 유전적 데이터는 또한 타우의 3R:4R 비율의 중요성을 강조하였다. FTD 야기하는 타우 돌연변이의 많은 것은 타우 스플라이싱에 있어 변화를 야기하고, 이는 엑손 10의 우선적 포함을 야기하며, 이로써 증가된 4R 타우를 야기한다. 전제 타우 수준은 정상이다. 타우 이소형 변화, 아미노산 변화, 또는 둘 다가 신경퇴행을 야기하는지에 대해서는 미지인 채로 남아있다. 최근 데이터는, PSP가 또한 증가된 4R:3R 타우 비율과 연관될 수 있다는 것을 암시한다.
신경퇴행에서의 타우 비율의 영향에 대한 이해를 돕기 위하여, 스플라이싱 타우 돌연변이 (N279K) 중 하나에 기반한 마우스 모델이 타우 프로모터 및 엑손 10의 측면 인트론 서열을 포함하는 미니유전자를 사용하여 생성되었다. 인간에서와 같이, 이러한 마우스는 WT 타우를 발현하는 형질전환체와 비교하여 4R 타우의 증가된 수준을 나타내며, 뇌 및 척수에서의 군집된 타우의 누적뿐만 아니라, 행동 및 운동적 이상을 발병시킨다.
단백질 "타우"는 알츠하이머 질환, 전두측두엽 치매, 진행성 핵상안근 마비, 뇌피질기저 신경절 퇴행, 권투선수 치매, 염색체 연관 파킨슨증, 리티코-보딕(lytico-bodig) 질환, 엉킴-우세 치매, 신경절교종, 신경절세포종, 뇌막혈관종증, 아급성 경화성 범뇌염, 연뇌증, 결절성 경화증, 할러포르덴-스파츠(Hallervorden-Spatz) 질환, 피크 질환, 호은성 입자 질환, 피질기저 신경퇴행, 또는 전측두엽 신경퇴행, 및 다른 것들을 포함하는 뇌의 다수 질환과 연관되어 있다. AD와 같은 타우-연관된 장애는 노인들에서의 치매의 가장 흔한 원인이다. AD는 전세계에서 1500만명, 및 85세 초과 인구 중 40%에 영향을 주는 것으로 추정된다. AD는 다음 두개의 병리학적 특징으로 특성화된다: 타우 신경섬유 포함물 (NFT) 및 아밀로이트-β (Aβ) 플라크.
현재 그러한 신경퇴행성 질환을 치료하기 위하여 수용가능한 선택사항에 대한 부족이 존재한다. 따라서, 본원에서는 그러한 질환에 치료 방법을 제공하기 위한 목적이 존재한다.
요약
타우 mRNA 및 단백질의 발현을 조절하기 위한 방법, 화합물, 및 조성물이 본원에서 제공된다. 특정 구현예에서, 타우 mRNA 및 단백질의 발현을 조절하기에 유용한 화합물은 안티센스 화합물이다. 특정 구현예에서, 안티센스 화합물은 안티센스 올리고뉴클레오타이드이다.
특정 구현예에서, 조절은 세포 또는 조직에서 발생할 수 있다. 특정 구현예에서, 상기 세포 또는 조직은 동물 내의 것이다. 특정 구현예에서, 상기 동물은 인간이다. 특정 구현예에서, 타우 mRNA 수준은 감소된다. 특정 구현예에서, 타우 단백질 수준은 감소된다. 그러한 감소는 시간-의존적 방식 또는 용량-의존적 방식으로 발생할 수 있다.
질환, 장애, 및 병태를 예방, 치료, 및 지연하는데 유용한 방법, 화합물, 및 조성물이 또한 제공된다. 특정 구현예에서, 그러한 타우 연관된 질환, 장애, 및 병태는 신경퇴행성 질환이다. 특정 구현예에서, 그러한 신경퇴행성 질환, 장애, 및 병태는 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 및 드라벳 증후군을 포함한다.
그러한 질환, 장애, 및 병태는 하나 이상의 위험인자, 원인 또는 결과를 공통적으로 가질 수 있다. 신경퇴행성 장애의 발달에 대한 특정 위험 인자 및 원인은 노화, 개인 또는 가족력, 또는 유전적 소인을 포함한다. 신경퇴행성 장애의 발달과 연관된 특정 증후군 및 결과는 비제한적으로 하기를 포함한다: 과인산화된 타우의 존재, 신경섬유 포함물의 존재, 신경 기능의 감소, 기억 감퇴, 운동 기능 감소, 운동 협응 감소 및 착란.
특정 구현예에서, 치료 방법은 타우 안티센스 화합물을 이를 필요로 하는 개체에게 투여하는 단계를 포함한다. 특정 구현예에서, 치료 방법은 타우 안티센스 올리고뉴클레오타이드를 이를 필요로 하는 개체에게 투여하는 단계를 포함한다.
본 개시사항은 하기 비제한적 수의 구현예를 제공한다.
구현예 1: 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 20-2443 및 서열 번호: 2478-2483의 핵염기 서열 중 임의의 것의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물.
구현예 2: 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 2444-2477 및 서열 번호: 2484-2565의 핵염기 서열 중 임의의 것의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물.
구현예 3: 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 20-2565의 핵염기 서열 중 임의의 것의 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물.
구현예 4: 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135783-135980와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물.
구현예 5: 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135853-135872와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물.
구현예 6: 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135783-135929와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물.
구현예 7: 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135783-135914와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물.
구현예 8: 구현예 4 내지 7의 화합물에 있어서, 상기 변형된 올리고뉴클레오타이드는 서열 번호: 1에 적어도 80%, 적어도 81%, 적어도 82%, 적어도 83%, 적어도 84%, 적어도 85%, 적어도 86%, 적어도 87%, 적어도 88%, 적어도 89%, 적어도 90%, 적어도 91%, 적어도 92%, 적어도 93%, 적어도 94%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 적어도 99%, 또는 100% 상보적일 수 있다.
구현예 9: 선행 구현예들 중 어느 하나에서, 단일 가닥 변형된 올리고뉴클레오타이드로 구성된, 화합물.
구현예 10: 선행 구현예들 중 어느 하나에서, 적어도 하나의 뉴클레오사이드간 연결은 변형된 뉴클레오사이드간 연결인, 화합물.
구현예 11: 구현예 10에 있어서, 적어도 하나의 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결인 화합물.
구현예 12: 청구항 10에 있어서, 각각의 변형된 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결인 화합물.
구현예 13: 선행 구현예들 중 어느 하나에서, 적어도 하나의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결인, 화합물.
구현예 14: 선행 구현예들 중 어느 하나에서, 적어도 하나의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이고, 적어도 하나의 뉴클레오사이드간 연결은 포스포디에스테르 연결인 화합물.
구현예 15: 선행 구현예들 중 어느 하나에서, 적어도 하나의 뉴클레오사이드는 변형된 핵염기를 포함하는, 화합물.
구현예 16: 구현예 15에 있어서, 상기 변형된 핵염기는 5-메틸시토신인, 화합물.
구현예 17: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드의 적어도 하나의 뉴클레오사이드는 변형된 당을 포함하는, 화합물.
구현예 18: 구현예 17에 있어서, 상기 적어도 하나의 변형된 당은 이환식 당인, 화합물.
구현예 19: 구현예 18에 있어서, 상기 이환식 당은 당 4'-CH2-N(R)-O-2' 가교의 2' 및 4' 위치 사이에서 화학적 연결을 포함하며, 이때 R은 독립적으로, H, C1-C12 알킬, 또는 보호기인, 화합물.
구현예 20: 구현예 18에 있어서, 상기 이환식 당은4'-CH2-N(R)-O-2' 가교를 포함하며, 이때 R은 독립적으로, H, C1-C12 알킬, 또는 보호기인, 화합물.
구현예 21: 구현예 17에 있어서, 적어도 하나의 변형된 당은 2'-O-메톡시에틸 기를 포함하는, 화합물.
구현예 22: 구현예 17에 있어서, 상기 변형된 당은 2'-O(CH2)2-OCH3 기를 포함하는, 화합물.
구현예 23: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는:
10 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는, 화합물.
구현예 24: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는:
9 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는, 화합물.
구현예 25: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는:
7 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는, 화합물.
구현예 26: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는:
8 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는, 화합물.
구현예 27: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는:
8 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
4개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는, 화합물.
구현예 28: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는:
8 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
6개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
4개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는, 화합물.
구현예 29: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는 20 개의 연결된 뉴클레오사이드로 이루어지는, 화합물.
구현예 30: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는 19개의 연결된 뉴클레오사이드로 이루어지는, 화합물.
구현예 31: 선행 구현예들 중 어느 하나에서, 상기 변형된 올리고뉴클레오타이드는 18개의 연결된 뉴클레오사이드로 이루어지는, 화합물.
구현예 32: 선행 구현예들 중 어느 하나의 화합물 또는 이의 염 및 약제학적으로 허용가능한 담체 또는 희석제 중 적어도 하나를 포함하는 조성물.
구현예 33: 선행 구현예들 중 어느 하나의 화합물 또는 조성물을 동물에 투여하는 단계를 포함하는 방법.
구현예 34: 구현예 33에 있어서, 상기 동물은 인간인, 방법.
구현예 35: 구현예 33에 있어서, 상기 화합물의 투여는 타우 연관된 질환, 장애 또는 병태를 예방, 치료, 개선 또는 이의 진행을 지연시키는, 방법.
구현예 36: 구현예 35에 있어서, 상기 질환, 장애, 및 병태는 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 또는 드라벳 증후군인, 방법.
구현예 37: 신경퇴행성 장애를 치료하기 위한 약제의 제조를 위한 선행 구현예들 중 어느 하나의 화합물 또는 조성물의 용도.
구현예 38: ISIS 613099 어진, 화합물.
구현예 39: ISIS 613361 어진, 화합물.
구현예 40: ISIS 613370 어진, 화합물.
구현예 41: ISIS 623782로 이루어진, 화합물.
구현예 42: ISIS 623996로 이루어진, 화합물.
구현예 43: 구현예 38 내지 42 중 어느 하나의 화합물 또는 이의 염 및 약제학적으로 허용가능한 담체 또는 희석제 중 적어도 하나를 포함하는, 조성물.
구현예 44: 구현예 38 내지 43 중 어느 하나의 화합물 또는 조성물을 투여하는 단계를 포함하는, 방법.
구현예 45: 구현예 44에 있어서, 상기 동물은 인간인, 방법.
구현예 46: 구현예 44에 있어서, 상기 화합물의 투여는 타우 연관된 질환, 장애 또는 병태를 예방, 치료, 개선 또는 이의 진행을 지연시키는, 방법.
구현예 47: 구현예 46에 있어서, 상기 질환, 장애, 및 병태는 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 또는 드라벳 증후군인, 방법.
구현예 48: 신경퇴행성 장애를 치료하기 위한 약제의 제조를 위한 구현예 38 내지 43 중 어느 하나의 화합물 또는 조성물의 용도.
전술된 일반적인 설명 및 하기 상세한 설명 모두는 단지 예시적이고 설명적인 것이며, 청구될 때 본 발명을 제한하지 않음이 이해되어야 한다. 본원에서, 단수의 사용은 달리 구체적으로 언급되지 않으면 복수를 포함한다. 본원에서 사용된 바와 같이, "또는"의 사용은 다른 식으로 명시되지 않는 한, "및/또는"을 의미한다. 또한, 본원에서 사용된 바와 같이, "및"의 사용은 다른 식으로 명시되지 않는 한, "및/또는"을 의미한다. 더욱이, 용어 "포함하는" 및 "포함한다" 및 "포함하였다"와 같은 다른 형태의 사용은 비제한적이다. 또한, "요소" 또는 "성분"은 다른 식으로 구체적으로 명시되지 않는 한, 하나의 단위를 포함하는 요소 및 성분들 및 하나 초과의 하부단위를 포함하는 요소 및 성분들 둘 다를 포괄한다.
본 명세서에서 사용된 섹션 제목들은 단지 조직적 목적을 위한 것이며, 기술된 요지를 제한하는 것으로 해석되지는 않는다. 허용되는 경우에, 모든 특허, 특허출원, 공개된 특허출원 및 다른 저널 출판물을 포함하여 (단, 이들로 제한되지는 않는다) 본 출원에서 인용된 모든 문서, 또는 문서의 일부분, 유전자 은행 (GENBANK) 수탁 번호 및 국립 바이오테크롤로지 정보 센터 (NCBI) 및 본 명세서에서 전체적으로 언급된 다른 데이터와 같은 데이터베이스를 통해 수득될 수 있는 관련된 서열 정보는 그 전체로, 또한 본원에서 거론된 문서의 일부분에 대한 참고로 포함된다.
정의
구체적인 정의가 제공되지 않는 한, 본 명세서에 기술된 분석 화학, 합성 유기 화학, 및 의학 및 약제학적 화학과 관련하여 이용된 명명법, 및 그의 절차 및 기술은 본 기술분야에서 잘 알려지고 통상적으로 사용되는 것들이다. 화학적 합성 및 화학적 분석을 위해서는 표준 기술이 사용될 수 있다.
다른 식으로 지적되지 않는 한, 하기 용어들은 하기의 의미를 갖는다:
"2'-O-메톡시에틸" (또한 2'-MOE 및 2'-OCH2CH2-OCH3 및 MOE)은 푸로실 환의 2' 위치의 O-메톡시-에틸 변형을 나타낸다. 2'-O-메톡시에틸 변형된 당은 변형된 당이다.
"2'-MOE 뉴클레오사이드" (또한 2'-O-메톡시에틸 뉴클레오사이드)는 2'-MOE 변형된 당 모이어티를 포함하는 뉴클레오사이드를 의미한다.
본원에서 사용된 바와 같이, "2'-치환된 뉴클레오사이드" 는 OH 이외의 푸라노 환의 2' 위치에서 치환체를 포함하는 뉴클레오사이드를 의미한다. 특정 구현예에서, 2' 치환된 뉴클레오사이드는 이환식 당 변형을 갖는 뉴클레오사이드를 포함한다.
"5-메틸시토신"은 5' 위치에 부착된 메틸기로 변형된 시토신을 의미한다. 5-메틸시토신은 변형된 핵염기이다.
"약"은 값의 ±7% 범위 내를 의미한다. 예를 들어, "화합물은 타우 억제의 적어도 약 70%만큼 영향을 미칠 수 있다"라고 언급된 경우에, 이것은 상기 타우 수준이 63%-77% 범위 내로 억제될 수 있음을 시사한다.
"수반하여 투여된다"는 둘 다의 약물학적 효과가 환자에게서 동시에 나타나도록 하는 임의의 방식으로의 두 가지 약제학적 제제의 공동-투여를 나타낸다. 수반되는 투여는 두 가지 약제학적 제제를 단일 약제학적 조성물로, 단일 투약형으로, 또는 동일한 투여 경로에 의해서 투여할 것을 필요로 하지 않는다. 두 가지 약제학적 제제의 효과는 그들 자체가 동시에 나타날 필요는 없다. 효과는 단지 기간의 중복이 필요할 뿐이며, 동일한 시간에 걸칠 필요는 없다.
"투여하는"은 약제학적 제제를 동물에게 제공하는 것을 의미하며, 의료 전문가에 의한 투여 및 자가-투여를 포함하지만 이들로 제한되지는 않는다.
"개선"은 연관된 질환, 장애 또는 상태의 적어도 하나의 지표, 징후 또는 증상을 약화시키는 것을 나타낸다. 지표의 중증도는 본 기술분야에서 숙련된 전문가에게 공지되어 있는 주관적 또는 객관적 척도에 의해서 결정될 수 있다.
"동물"은 마우스, 랫트, 토끼, 개, 고양이, 돼지, 및 원숭이 및 침팬지를 포함한 (단, 이들로 제한되지는 않는다) 비-인간 영장류를 포함하는 (단, 이들로 제한되지는 않는다) 인간 또는 비-인간 동물을 나타낸다.
"항체"는 일부 경우에서 항원과 특이적으로 반응함으로써 특징화되는 분자를 지칭하며, 여기서 항체 및 항원은 각각 다른 용어에서 정의된다. 항체는 완전한 항체 분자 또는 이의 임의의 단편 또는 영역, 예컨대 중쇄, 경쇄, Fab 영역, 및 Fc 영역을 지칭할 수 있다.
"안티센스 활성"은 안티센스 화합물의 그의 표적 핵산에 대한 혼성화에 기인할 수 있는 특정 검출 가능하거나 측정 가능한 활성을 의미한다. 특정 구현예에서, 안티센스 활성은 표적 핵산 또는 이러한 표적 핵산에 의해서 암호화된 단백질의 양 또는 발현의 감소이다.
"안티센스 화합물"은 수소 결합을 통해서 표적 핵산에 대한 혼성화를 겪을 수 있는 올리고머 화합물을 의미한다. 안티센스 화합물의 예시는 단일 가닥 및 이중 가닥 화합물, 예컨대 안티센스 올리고뉴클레오타이드, siRNA, shRNA, ssRNA, 및 점유도-기반 화합물을 포함한다.
"안티센스 억제"는 안티센스 화합물의 부재 하에서의 표적 핵산 수준에 비하여, 표적 핵산에 대해 상보적인 안티센스 화합물의 존재 하에서의 표적 핵산 수준의 감소를 의미한다.
"안티센스 기전"은 표적 핵산을 갖는 화합물의 혼성화를 포함하는 모든 기전이며, 여기서 상기 혼성화의 결과 또는 효과는 예를 들어 전사 또는 스플라이싱을 포함하는 세포 기작의 수반된 스톨링(stalling)을 갖는 표적 저하 또는 표적 점유이다.
"안티센스 올리고뉴클레오타이드"는 표적 핵산의 상응하는 분절에 대한 혼성화를 허용하는 핵염기 서열을 갖는 단일-가닥 올리고뉴클레오타이드를 의미한다.
"염기 상보성"은 표적 핵산 (즉, 혼성화)에서의 상응하는 핵염기를 갖는 안티센스 올리고뉴클레오타이드의 핵염기의 정확한 염기 짝짓기에 대한 능력을 지칭하며, 이는 상응하는 핵염기 사이의 왓슨-크릭, 후그스텐 또는 역방향 후그스텐 수소 결합에 의하여 매개된다.
"이환식 당"은 두 개의 원자의 가교화 (bridging)에 의해서 변형된 푸로실 환을 의미한다. 이환식 당은 변형된 당이다.
"이환식 핵산" (또는 BNA)는 당 환의 두 개의 탄소 원자를 연결하는 가교를 포함하는 당 모이어티를 갖고, 이로써 이환식 환계를 형성하는 뉴클레오사이드를 의미한다. 특정 구현예에서, 상기 가교는 상기 당 환의 4'-탄소 및 2' 탄소를 연결한다.
"캡 (cap) 구조" 또는 "말단 캡 모이어티"는 안티센스 화합물의 어느 하나의 말단에 포함된 화학적 변형을 의미한다.
"cEt" 및 "제한된 에틸"은 4'-탄소 및 2' 탄소를 연결하는 가교를 포함하는 당 모이어티를 갖는 이환식 뉴클레오사이드를 의미하며, 이때 상기 가교는 하기 화학식: 4'-CH(CH3)-O-2'를 갖는다.
"제한된 에틸 뉴클레오사이드" (또한 cEt 뉴클레오사이드)는 4'-CH(CH3)-O-2' 가교를 포함하는 이환식 모이어티를 포함하는 뉴클레오사이드를 의미한다.
"화학적으로 구분되는 영역"은 특정 점에서 동일한 안티센스 화합물의 또 다른 영역과 화학적으로 상이한 안티센스 화합물의 영역을 나타낸다. 예를 들어, 2'-O-메톡시에틸 뉴클레오사이드를 갖는 영역은 2'-O-메톡시에틸 변형이 없는 뉴클레오사이드를 갖는 영역과 화학적으로 구분된다.
"키메라 안티센스 화합물"은 적어도 두 개의 화학적으로 구분되는 영역을 갖고, 각 위치는 다수의 서브유닛을 갖는 안티센스 화합물을 의미한다.
"공동-투여"는 개체에게 두 개 이상의 약제학적 제제를 투여하는 것을 의미한다. 두 개 이상의 약제학적 제제는 단일 약제학적 조성물 내에 존재할 수 있거나, 별개의 약제학적 조성물 내에 존재할 수 있다. 상기 두 개 이상의 약제학적 조성물 각각은 동일하거나 상이한 투여 경로를 통해서 투여될 수 있다. 공동-투여는 병행 또는 순차적 투여를 포괄한다.
"상보성"은 제1 핵산과 제2 핵산의 핵염기 사이의 짝짓기 능력을 의미한다.
"포함하다", "포함하다" 및 "포함하는" 은 언급된 단계 또는 요소, 또는 단계 또는 요소의 집합의 포함을 의미하지만, 임의의 다른 단계 또는 요소의 집합을 암시하는 것으로 이해될 것이다.
"인접 핵염기"는 서로에 대해 바로 인접한 핵염기를 의미한다.
"설계" 또는 "~하도록 설계된"은 선택된 핵산 분자와 특이적으로 혼성화하는 올리고머 화합물을 설계하는 과정을 지칭한다.
"희석제"는 약물학적 활성을 결여하고 있지만, 약제학적으로 필요하거나 바람직한 조성물 내의 성분을 의미한다. 예를 들어, 주사용 약물에서, 희석제는 액체, 예를 들어, 식염수일 수 있다.
"용량"은 단일 투여에서, 또는 명시된 기간 동안에 제공된 약제학적 제제의 명시된 양을 의미한다. 특정 구현예에서, 용량은 1, 또는 2 이상의 볼러스 (bolus), 정제, 또는 주사제로 투여될 수 있다. 예를 들어, 피하 투여를 원하는 특정 구현예에서, 원하는 용량은 단일 주사에 의해서 쉽게 수용되지 않는 용적을 필요로 하며, 따라서 2 이상의 주사제를 사용하여 원하는 용량을 달성할 수 있다. 특정 구현예에서, 약제학적 작용제는 장시간에 걸쳐서, 또는 연속적으로 주입함으로써 투여된다. 용량은 시간, 일, 주, 또는 개월 당 약제학적 제제의 양으로 언급될 수 있다.
병태를 치료 또는 예방의, 또는 이의 활성을 조절하는 맥락에서, "효과적인 양"은 그러한 조절, 치료, 또는 예방을 필요로 하는 대상체에 약제학적 제제의 그와 같은 양을, 그러한 병태의 치료 또는 예방 또는 개선을 위하여, 또는 그러한 병태의 효과 조절에 대해 효과적인, 단일 투여 또는 일련의 것 중 부분으로 투여하는 것을 의미한다. 유효량은 치료될 개체의 건강 및 신체 조건, 치료될 개체의 분류군, 조성물의 제형, 개체의 의학적 상태의 평가, 및 그 밖의 다른 관련된 인자에 따라 개체들 사이에서 달라질 수 있다.
"효능"은 원하는 효과를 생성하는 능력을 의미한다.
"발현"은 유전자 암호화된 정보가 세포 내에서 존재 및 작동하는 구조로 전환되는 모든 기능을 포함한다. 그러한 구조는 비제한적으로 전사 및 번역의 생성물을 포함한다.
"완전히 상보적" 또는 "100% 상보적"은 제1 핵산의 각각의 핵염기가 제2 핵산 내에 상보적인 핵염기를 갖는 것을 의미한다. 특정 구현예에서, 제1 핵산은 안티센스 화합물이고, 표적 핵산은 제2 핵산이다.
"갭머 (gapmer)"는 RNase H 분해를 지지하는 다수의 뉴클레오사이드를 갖는 내부 영역이 하나 또는 그 이상의 뉴클레오사이드를 갖는 외부 영역들 사이에 배치된 키메라 안티센스 화합물을 의미하며, 이때 상기 내부 영역을 포함하는 뉴클레오사이드는 상기 외부 영역을 포함하는 뉴클레오사이드 또는 뉴클레오사이드들과 화학적으로 구분된다. 내부 영역은 "갭"로 지칭될 수 있으며, 외부 영역은 "윙 (wing)"로 지칭될 수 있다.
"갭-한정된 (gap-narrowed)"은 1 내지 6 개의 뉴클레오사이드를 갖는 5' 및 3' 윙 분절들 사이에, 및 이들에 바로 인접하여 배치된 9개 이하의 인접 2'-데옥시리보뉴클레오사이드의 갭 분절을 갖는 키메라 안티센스 화합물을 의미한다.
"갭-확장된 (gap-widened)"은 1 내지 6 개의 뉴클레오사이드를 갖는 5' 및 3' 윙 분절들 사이에, 및 이들에 바로 인접하여 배치된 12 개 또는 그 이상의 인접 2'-데옥시리보뉴클레오사이드의 갭 분절을 갖는 키메라 안티센스 화합물을 의미한다.
"혼성화"는 상보적 핵산 분자의 어닐링 (annealing)을 의미한다. 특정 구현예에서, 상보적 핵산 분자는 비제한적으로 안티센스 화합물 및 표적 핵산을 포함한다. 특정 구현예에서, 상보적 핵산 분자는 비제한적으로 안티센스 올리고뉴클레오타이드 및 핵산 표적을 포함한다.
"타우 연관된 질환을 갖는 동물을 동정하는 것"은 타우 연관된 질환으로 진단되었거나 타우 연관된 질병을 발병할 소인이 있는 동물을 동정하는 것을 의미한다. 타우 연관된 질병을 발병할 소인이 있는 개체는 노화, 개인 또는 가족력, 또는 유전적 소인 중 하나 이상의 타우 연관된 질병 소인을 포함하는, 타우 연관된 질병 발병에 대한 하나 이상의 위험 인자를 갖는 개체를 포함한다. 그러한 동정은 개체의 병력 및 표준 임상 시험 또는 평가, 예컨대 유전자 시험을 평가하는 단계를 포함하는 임의의 방법에 의하여 수반될 수 있다.
"바로 인접한"은 바로 인접한 요소들 사이에 개입성 요소가 없는 것을 의미한다.
"개체" 는 치료 또는 요법을 위해서 선택된 인간 또는 비-인간 동물을 의미한다.
"타우 억제"는 타우 mRNA 및/또는 단백질의 발현 수준을 감소시키는 것을 의미한다. 특정 구현예에서, 타우 mRNA 및/또는 단백질 수준은, 타우 안티센스 화합물, 예컨대 안티센스 올리고뉴클레오타이드의 부재 하에서 타우 mRNA 및/또는 단백질 수준의 발현과 비교하여, 타우를 표적화하는 안티센스 올리고뉴클레오타이드를 포함하는 타우를 표적화하는 안티센스 화합물의 존재 하에서 억제된다.
"발현 또는 활성을 억제하는"은 발현 또는 활성의 감소 또는 차단을 나타내며, 반드시 발현 또는 활성의 전체 제거를 나타내지는 않는다.
"뉴클레오사이드간 연결"은 뉴클레오사이드들 사이의 화학적 결합을 나타낸다.
"연결된 뉴클레오사이드"는 뉴클레오사이드간 연결에 의하여 함께 연결된 인접한 뉴클레오사이드를 의미한다.
"잠금(locked) 핵산" 또는 " LNA" 또는 "LNA 뉴클레오사이드"는 뉴클레오사이드 당 단위의 4' 및 2' 위치 사이의 두 개의 탄소 원자를 연결하는 가교를 갖는 핵산 모노머를 의미한다. 이환식 당의 예시는, 비제한적으로, 하기 묘사된 (A) α-L-메틸렌옥시 (4'-CH2-O-2') LNA, (B) β-D-메틸렌옥시 (4'-CH2-O-2') LNA, (C) 에틸렌옥시 (4'-(CH2)2-O-2') LNA, (D) 아미노옥시 (4'-CH2-O-N(R)-2') LNA, 및 (E) 옥시아미노 (4'-CH2-N(R)-O-2') LNA를 포함한다.
본원에서 사용된 바와 같이, LNA 화합물은, 비제한적으로, 당의 4' 및 2' 위치 사이의 적어도 하나의 가교를 갖는 화합물을 포함하고, 여기서 상기 가교 중 각각은 독립적으로, -[C(R1)(R2)]n-, -C(R1)=C(R2)-, -C(R1)=N-, -C(=NR1)-, -C(=O)-, -C(=S)-, -O-, -Si(R1)2-, -S(=O)x- 및 -N(R1)-로부터 독립적으로 선택된 1 또는 2 내지 4개의 연결기를 포함한다; 여기서 x는 0, 1, 또는 2이고; n은 1, 2, 3, 또는 4이고; R1 및 R2 각각은, 독립적으로, H, 보호기, 하이드록실, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 헤테로환 라디칼, 치환된 헤테로환 라디칼, 헤테로아릴, 치환된 헤테로아릴, C5-C7 지환식 라디칼, 치환된 C5-C7 지환식 라디칼, 할로겐, OJ1, NJ1J2, SJ1, N3, COOJ1, 아실 (C(=O)-H), 치환된 아실, CN, 설포닐 (S(=O)2-J1), 또는 설폭실 (S(=O)-J1)이고; 그리고 J1 및 J2 각각은 독립적으로, H, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 아실 (C(=O)-H), 치환된 아실, 헤테로환 라디칼, 치환된 헤테로환 라디칼, C1-C12 아미노알킬, 치환된 C1-C12 아미노알킬 또는 보호기이다.
LNA 정의 내에 포괄된 4' - 2' 가교기의 예시는, 다음 화학식 중 하나를 포함하지만 이들로 제한되는 것은 아니다: -[C(R1)(R2)]n-, -[C(R1)(R2)]n-O-, -C(R1R2)-N(R1)-O- 또는 -C(R1R2)-O-N(R1)-. 더욱이, LNA의 정의 내에서 포괄된 다른 가교 그룹은 4'-CH2-2', 4'-(CH2)2-2', 4'-(CH2)3-2', 4'-CH2-O-2', 4'-(CH2)2-O-2', 4'-CH2-O-N(R1)-2' 및 4'-CH2-N(R1)-O-2'- 가교이고, 이때 R1 및 R2 각각은 독립적으로, H, 보호기, 또는 C1-C12 알킬이다.
또한 본 발명에 따른 LNA의 정의 내에 포함된 것은 리보실 당 환의 2'-하이드록실 기가 당 환의 4' 탄소 원자와 연결되어, 이로써 이환식 당 모이어티를 형성하는 메틸렌옥시 (4'-CH2-O-2') 가교를 형성하는 LNA이다. 상기 가교는 또한 2' 산소 원자 및 4' 탄소 원자를 연결하는 메틸렌 (-CH2-)기일 수 있으며, 이에 대해 용어 메틸렌옥시 (4'-CH2-O-2') LNA가 사용된다. 더욱이, 이러한 위치에서 에틸렌 가교 그룹을 갖는 이환식 당 모이어티의 경우에서, 용어 에틸렌옥시 (4'-CH2CH2-O-2') LNA가 사용된다. α -L- 메틸렌옥시 (4'-CH2-O-2'), 메틸렌옥시 (4'-CH2-O-2') LNA의 이성질체는 또한 본원에 사용된 바와 같이 LNA의 정의 내에 포괄된다.
"미스매치 (mismatch)" 또는 "비-상보적 핵염기"는 제1 핵산의 핵염기가 제2 또는 표적 핵산의 상응하는 핵염기와 짝짓기 할 수 없는 경우를 지칭한다.
"변형된 뉴클레오사이드간 연결"은 천연적으로 발생하는 뉴클레오사이드간 결합 (즉, 포스포디에스테르 뉴클레오사이드간 결합)으로부터의 치환 또는 특정 변화를 지칭한다.
"변형된 핵염기"는 아데닌, 시토신, 구아닌, 티미딘, 또는 우라실 이외의 임의의 핵염기를 의미한다. "비변형된 핵염기"는 퓨린 염기인 아데닌 (A) 및 구아닌 (G), 및 피리미딘 염기인 티민 (T), 시토신 (C), 및 우라실 (U)을 의미한다.
"변형된 뉴클레오사이드"는 독립적으로, 변형된 당 모이어티 및/또는 변형된 핵염기를 갖는 뉴클레오사이드를 의미한다.
"변형된 뉴클레오타이드"는 독립적으로, 변형된 당 모이어티, 변형된 뉴클레오사이드간 연결, 및/또는 변형된 핵염기를 갖는 뉴클레오타이드를 의미한다.
"변형된 올리고뉴클레오타이드"는 적어도 하나의 뉴클레오사이드간 연결, 변형된 당, 및/또는 변형된 핵염기를 포함하는 올리고뉴클레오타이드를 의미한다.
"변형된 당"은 천연 당 모이어티로부터의 치환 및/또는 변화를 나타낸다.
"모노머"는 올리고머의 단일 단위를 의미한다. 모노머는 비제한적으로, 천연 발생하거나 변형된 뉴클레오사이드 및 뉴클레오타이드를 포함한다.
"모티프"는 안티센스 화합물 내에서 비변형 및 변형된 뉴클레오사이드의 패턴을 의미한다.
"천연 당 모이어티"는 DNA (2'-H) 또는 RNA (2'-OH)에서 발견되는 당 모이어티를 의미한다.
"천연적으로 발생하는 뉴클레오사이드간 연결"은 3' 내지 5' 포스포디에스테르 연결을 의미한다.
"비-상보적 핵염기"는 다른 하나와 수소 결합을 형성하거나 달리 혼성화를 지지하지 않는 핵염기 쌍을 지칭한다.
"핵산"은 모노머 뉴클레오타이드로 구성된 분자를 나타낸다. 핵산은 비제한적으로 리보핵산 (RNA), 데옥시리보핵산 (DNA), 단일-가닥 핵산, 이중-가닥 핵산, 소형 개입성 리보핵산 (siRNA), 및 마이크로RNAs (miRNA)가 포함한다.
"핵염기"는 또 다른 핵산의 염기와 짝짓기 할 수 있는 헤테로환 모이어티를 의미한다.
"핵염기 상보성"은 다른 핵염기와 염기 짝짓기를 할 수 있는 핵염기를 지칭한다. 예를 들어, DNA에서, 아데닌 (A)은 티민 (T)과 상보적이다. 예를 들어, RNA에서, 아데닌 (A)은 우라실 (U)와 상보적이다. 특정 구현예에서, 상보적 핵염기는 이의 표적 핵산의 핵염기와 염기 짝짓기를 할 수 있는 안티센스 화합물의 핵염기를 지칭한다. 예를 들어, 만약 안티센스 화합물의 특정 위치에서의 핵염기가 표적 핵산의 특정 위치에서의 핵염기와 수소 결합을 할 수 있다면, 상기 올리고뉴클레오타이드 및 상기 표적 핵산 사이의 수소 결합 위치는 그러한 핵염기 쌍에서 상보적이라고 고려된다.
"핵염기 서열"은 임의의 당, 연결 및/또는 핵염기 변형에 독립적인 인접 핵염기의 순서를 의미한다.
"뉴클레오사이드"는 당에 연결된 핵염기를 의미한다.
"뉴클레오사이드 모방체"는 당 또는 당 및 염기, 및 필수적은 아니나 하나 이상의 위치에서의 연결을, 예를 들어, 모폴리노, 사이클로헥세닐, 사이클로헥실, 테트라하이드로피라닐, 바이사이클로 또는 트리사이클로 당 모방체, 예를 들어, 비-푸라노즈 당 단위를 갖는 뉴클레오사이드 모방체와 같은 올리고머 화합물로 대체하기 위하여 사용된 이들 구조를 포함한다. 뉴클레오타이드 모방체는 뉴클레오사이드 및 하나 이상의 위치에서의 연결을, 예를 들어, 펩타이드 핵산 또는 모폴리노 (-N(H)-C(=O)-O- 또는 다른 비-포스포디에스테르 연결에 의해서 연결된 모폴리노)와 같은 올리고머 화합물로 대체하기 위하여 사용된 이들 구조를 포함한다. 당 대용물은 조금 더 넓은 용어 뉴클레오사이드 모방체와 중복되나, 오직 당 단위 (푸라노스 환)의 대체를 지시하도록 의도된다. 본원에 제공된 테트라히드로피라닐 환은 당 대용물의 예로 예시되고, 이때 푸라노스 당 그룹은 테트라히드로피라닐 환계(ring system)로 대체되었다. "모방체"는 당, 핵염기, 및/또는 뉴클레오사이드간 연결을 대체하는 그룹을 지칭한다. 일반적으로, 모방체는 당 또는 당-뉴클레오사이드간 연결 조합물을 대신하여 사용되고, 핵염기는 선택된 표적으로의 혼성화를 위하여 유지된다.
"뉴클레오타이드"는 뉴클레오사이드의 당 부분에 공유 연결된 인산기를 갖는 뉴클레오사이드를 의미한다.
"오프-타겟 효과"는 의도된 표적 핵산 이외의 유전자의 RNA 또는 단백질 발현 조절과 연관된 원하지 않거나 유해한 생물학적 효과를 지칭한다.
"올리고머 화합물" 또는 "올리고머"는 적어도 하나의 핵산 분자의 영역에 혼성화할 수 있는, 연결된 모노머 하부단위의 중합체를 의미한다.
"올리고뉴클레오타이드"는 각각 서로 독립적으로 변형되거나 비변형될 수 있는, 연결된 뉴클레오사이드의 중합체를 의미한다.
"비경구 투여"는 주사 (예컨대 볼러스 주사) 또는 주입을 통한 투여를 의미한다. 비경구 투여에는 피하 투여, 정맥내 투여, 근육내 투여, 동맥내 투여, 복강내 투여, 또는 두개내 투여, 예를 들어, 척추강내 또는 뇌실내 투여가 포함된다.
"펩타이드"는 아미드 결합에 의해 적어도 두 개의 아미노산을 연결시킴으로써 형성된 분자를 의미한다. 제한 없이, 본원에서 사용된 바와 같이, 펩티드는 폴리펩티드 및 단백질을 지칭한다.
"약제학적 제제"는 개체에게 투여하였을 때 치료학적 이점을 제공하는 물질을 의미한다. 예를 들어, 특정 구현예에서, 타우에 표적화된 안티센스 올리고뉴클레오타이드가 약제학적 제제이다.
"약제학적 조성물"은 개체에게 투여하는데 적합한 물질의 혼합물을 의미한다. 예를 들어, 약제학적 조성물은 안티센스 올리고뉴클레오타이드 및 멸균 수용액을 포함할 수 있다.
"약제학적으로 허용가능한 유도체"는 본 명세서에 기술된 화합물의 약제학적으로 허용가능한 염, 공액체, 프로드러그 (prodrug) 또는 이성질체를 포괄한다.
"약제학적으로 허용가능한 염"은 안티센스 화합물의 생리적으로 및 약제학적으로 허용가능한 염, 즉, 모체 올리고뉴클레오타이드의 원하는 생물학적 활성을 보유하며, 원치 않는 독물학적 효과를 그에 부여하지 않는 염을 의미한다.
"포스포로티오에이트 연결"은 포스포디에스테르 결합이 비-가교화 산소 원자들 중의 하나를 황 원자로 대체시킴으로써 변형된 뉴클레오사이드 간의 연결을 의미한다. 포스포로티오에이트 연결은 변형된 뉴클레오사이드간 연결이다.
"부분"은 핵산의 인접 (즉, 연결된) 핵염기의 규정된 수를 의미한다. 특정 구현예에서, 부분은 표적 핵산의 인접 핵염기의 규정된 수이다. 특정 구현예에서, 부분은 안티센스 화합물의 인접 핵염기의 규정된 수이다.
"예방하다" 또는 "예방하는"은 질환, 장애 또는 병태의 시작 또는 발전을 몇 분 내지 몇주, 몇달, 또는 무한대의 기간 동안 지연시키거나 미연에 방지하는 것을 지칭한다.
"프로드러그"은 내인성 효소 또는 다른 화합물질 및/또는 조건의 작용에 의해 신체 또는 세포 내에서 활성 형태(즉, 약물)로 전환되는 불활성 형태로 제조된 치료제를 의미한다.
"예방학적 유효량"은 동물에게 예방학적 또는 예방적인 이점을 제공하는 약제학적 제제의 양을 의미한다.
"영역"은 적어도 하나의 식별가능한 구조, 기능 또는 특성을 갖는 표적 핵산의 부분으로서 정의된다.
"리보뉴클레오타이드"는 뉴클레오타이드의 당 부분의 2' 위치에 하이드록시를 갖는 뉴클레오타이드를 의미한다. 리보뉴클레오타이드는 다양한 치환체 중 임의의 것으로 변형될 수 있다.
"염"은 안티센스 화합물의 생리적으로 및 약제학적으로 허용가능한 염, 즉, 모체 올리고뉴클레오타이드의 원하는 생물학적 활성을 보유하며, 원치 않는 독물학적 효과를 그에 부여하지 않는 염을 의미한다.
"분절"은 표적 핵산 내의 더 작거나 하부-부분의 영역으로서 정의된다.
본원에 기술된 "짧아진" 또는 "절단된" 버전의 안티센스 올리고뉴클레오타이드는하나, 또는 둘 이상의 결실된 뉴클레오사이드를 갖는다.
"부작용"은 원하는 효과 이외에 치료에 기인하는 생리적 반응을 의미한다. 특정 구현예에서, 부작용은 비제한적으로 주사 부위 반응, 간 기능 시험 이상, 신장 기능 이상, 간독성, 신장 독성, 중추신경계 이상, 근병증, 및 권태감을 포함한다.
"단일-가닥 올리고뉴클레오타이드"는 상보적 가닥에 혼성화되지 않은 올리고뉴클레오타이드를 의미한다.
본원에서 사용된 바와 같이, "부위"는 표적 핵산 내의 특별한 핵염기 위치로 정의된다.
"진행 지연"은 상기 질환의 발병에서의 감소를 의미한다.
"특이적으로 혼성화할 수 있는"은 특이적 연결이 바람직한 조건 하에서, 즉 체내 검정 및 치료학적 치료의 경우에 생리적 조건 하에서, 비-표적 핵산에 대해서는 최소의 효과를 나타내거나 효과를 나타내지 않으면서, 안티센스 올리고뉴클레오타이드 및 표적 핵산 사이에서 원하는 효과를 유도하기에 충분한 정도의 상보성을 갖는 안티센스 화합물을 지칭한다.
"엄격한 혼성화 조건" 또는 "엄격한 조건"은 올리고머 화합물이 이의 표적 서열에 혼성화할 것이나, 다른 서열에는 이의 최소 수로 혼성화할 것인 조건을 의미한다.
"대상체" 는 치료 또는 요법을 위해서 선택된 인간 또는 비-인간 동물을 의미한다.
"표적"은 이의 조절을 원하는 단백질을 지칭한다.
"표적 유전자"는 표적을 암호화하는 유전자를 지칭한다.
"표적화" 또는 "표적화된"은 표적 핵산에 특이적으로 혼성화하여 원하는 효과를 유도할 것인, 안티센스 화합물의 설계 및 선택의 과정을 의미한다.
"표적 핵산", "표적 RNA", 및 "표적 RNA 전사체" 및 "핵산 표적"은 모두 안티센스 화합물에 의해서 표적화될 수 있는 핵산을 의미한다.
"표적 영역"은 하나 이상의 안티센스 화합물이 표적화된, 표적 핵산의 부분을 의미한다.
"표적 분절"은 안티센스 화합물이 표적화된, 표적 핵산의 뉴클레오타이드의 서열을 의미한다. "5' 표적 부위"는 표적 분절의 5'-모스트(most) 뉴클레오타이드를 나타낸다. "3' 표적 부위"는 표적 분절의 3'-모스트 뉴클레오타이드를 나타낸다.
"타우"는 인간 미세소관-연관된 단백질 타우(MAPT)를 포함하는 포유류 미세소관-연관된 단백질 타우 (MAPT)를 의미한다.
"타우 연관된 질환"은 임의의 타우 핵산 또는 이의 발현 생성물과 연관된 임의의 질환을 의미한다. 그러한 질환은 신경퇴행성 질환을 포함할 수 있다. 그러한 신경퇴행성 질환은 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 및 드라벳 증후군을 포함한다.
"타우 mRNA"는 타우를 암호화하는 임의의 DNA 서열의 메신저 RNA 발현 생성물을 의미한다.
"타우 핵산"은 타우를 암호화하는 임의의 핵산을 의미한다. 예를 들어, 특정 구현예에서, 타우 핵산은 타우를 암호화한 DNA 서열, 타우를 암호화한 DNA (인트론 및 엑손을 포함하는 게놈 DNA를 포함)로부터 전사된 RNA 서열, 및 타우를 암호화한 mRNA 서열을 포함한다. "타우 mRNA"는 타우 단백질을 암호화한 mRNA를 의미한다.
"타우 단백질"은 타우 핵산의 폴리펩티드 발현 생성물을 의미한다.
"치료학적 유효량"은 개체에게 치료학적 이점을 제공하는 치료학적 제제의 양을 의미한다.
"치료하다" 또는 "치료하는" 또는 "치료"는 질병 또는 병태의 변경 또는 개선을 달성하기 위해서 조성물을 투여하는 것을 지칭한다.
"비변형된 핵염기"는 퓨린 염기인 아데닌 (A) 및 구아닌 (G), 및 피리미딘 염기인 티민 (T), 시토신 (C), 및 우라실 (U)을 의미한다.
"비변형 뉴클레오타이드"는 천연적으로 발생하는 핵염기, 당 모이어티, 및 뉴클레오사이드간 연결으로 구성된 뉴클레오타이드를 의미한다. 특정 구현예에서, 비변형 뉴클레오타이드는 RNA 뉴클레오타이드 (즉, β-D-리보뉴클레오사이드) 또는 DNA 뉴클레오타이드 (즉, β-D-데옥시리보뉴클레오사이드)이다.
"윙 분절"은 예컨대 개선된 억제 활성, 표적 핵산에 대한 증가된 결합 친화도, 또는 체내 핵염기에 의한 저하에 대한 저항성과 같은 올리코뉴클레오타이드 특성을 부여하기 위하여 변형된 다수의 뉴클레오사이드를 의미한다.
특정 구현예
특정 구현예는 타우 mRNA 및 단백질 발현을 억제하기 위한 방법, 화합물, 및 조성물을 제공한다. 특정 구현예는 타우 mRNA 및 단백질 수준을 감소시키기 위한 방법, 화합물, 및 조성물을 제공한다.
특정 구현예는 타우 핵산에 표적화된 안티센스 화합물을 제공한다. 특정 구현예에서, 타우 핵산은 뉴클레오타이드 9240000-9381000로부터 절단된 유전자 은행 수탁 번호 유전자 은행 수탁 번호 NT_010783.15 (본원에서 서열 번호: 1과 같이 포함), 유전자 은행 수탁 번호 NM_001123066.3 (본원에서 서열 번호: 2와 같이 포함) 엑손 3, 4, 6, 8, 10, 및 12를 건너뛰는 유전자 은행 수탁 번호 NM_016841.4, 변이체 mRNA 서열 (본원에서 서열 번호: 3과 같이 포함) 뉴클레오타이드 2624000-2761000로부터 절단된 유전자 은행 수탁 번호 NT_010783.14 (본원에서 서열 번호: 4와 같이 포함) 유전자 은행 수탁 번호 DR002467.1 (본원에서 서열 번호: 5와 같이 포함) 유전자 은행 수탁 번호 NM_001203251.1 (본원에서 서열 번호: 6과 같이 포함) 및 유전자 은행 수탁 번호 NM_016835.4 (본원에서 서열 번호: 7과 같이 포함)에 제시된 서열이다.
특정 구현예는 이를 필요로 하는 개체에서 타우와 연관된 질환, 장애 및 병태의 치료, 예방, 또는 개선을 위한 방법을 제공한다. 타우 연관된 질환, 장애 또는 병태의 치료, 예방, 또는 개선용 약제의 제조를 위한 방법이 또한 고려된다. 타우 연관된 질환, 장애, 및 병태는 신경퇴행성 질환을 포함한다. 특정 구현예에서, 타우 연관된 질환은 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 또는 드라벳 증후군을 포함한다.
특정 구현예는 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 20-2443 및 서열 번호: 2478-2483의 핵염기 서열 중 임의의 것 중 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다.
특정 구현예는 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 2444-2477 및 서열 번호: 2484-2565의 핵염기 서열 중 임의의 것 중 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다.
특정 구현예는 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 20-2565의 핵염기 서열 중 임의의 것 중 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다.
특정 구현예는 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135783-135980와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 포함하는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다.
특정 구현예는 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135853-135872와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 포함하는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다.
특정 구현예는 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135783-135929와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 포함하는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다.
특정 구현예는 12 내지 30 개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1의 핵염기 135783-135914와 동등한 길이 부분에 상보적인 적어도 8개, 적어도 9개, 적어도 10개, 적어도 11개, 적어도 12개, 적어도 13개, 적어도 14개, 적어도 15개, 적어도 16개, 적어도 17개, 적어도 18개, 적어도 19개, 또는 적어도 20개의 인접 핵염기를 포함하는 핵염기 서열을 포함하는 변형된 올리고뉴클레오타이드를 포함하는 화합물을 제공한다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드의 핵염기 서열은 서열 번호: 1에 적어도 80%, 적어도 81%, 적어도 82%, 적어도 83%, 적어도 84%, 적어도 85%, 적어도 86%, 적어도 87%, 적어도 88%, 적어도 89%, 적어도 90%, 적어도 91%, 적어도 92%, 적어도 93%, 적어도 94%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 적어도 99%, 또는 100% 상보적이다.
특정 구현예에서, 화합물은 단일-가닥 변형된 올리고뉴클레오타이드로 이루어진다.
특정 구현예에서, 변형된 올리고뉴클레오타이드의 적어도 하나의 뉴클레오사이드간 연결은 변형된 뉴클레오사이드간 연결이다.
특정 구현예에서, 적어도 하나의 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결이다.
특정 구현예에서, 각각의 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결이다.
특정 구현예에서, 적어도 하나의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이다.
특정 구현예에서, 적어도 하나의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이고, 적어도 하나의 뉴클레오사이드간 연결은 포스포디에스테르 연결이다.
특정 구현예에서, 적어도 하나의 뉴클레오사이드는 변형된 핵염기를 포함한다.
특정 구현예에서, 변형된 핵염기는 5-메틸시토신이다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드의 적어도 하나의 뉴클레오사이드는 변형된 당을 포함한다.
특정 구현예에서, 상기 적어도 하나의 변형된 당은 이환식 당이다.
특정 구현예에서, 상기 이환식 당은 당 4'-CH2-N(R)-O-2' 가교의 2' 및 4' 위치 사이에서 화학적 연결을 포함하며, 이때 R은 독립적으로, H, C1-C12 알킬, 또는 보호기이다.
특정 구현예에서, 상기 이환식 당은 4'-CH2-N(R)-O-2' 가교를 포함하며, 이때 R은 독립적으로, H, C1-C12 알킬, 또는 보호기이다.
특정 구현예에서, 상기 적어도 하나의 변형된 당은 2'-O-메톡시에틸 기를 포함한다.
특정 구현예에서, 상기 변형된 당 모이어티는 2'-O(CH2)2-OCH3 기를 포함한다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드는:
10 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드는:
9 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드는:
7 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드는:
8 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드는:
8 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
4개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
특정 구현예에서, 상기 변형된 올리고뉴클레오타이드는:
8 개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
6개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
4개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함한다.
특정 구현예에서, 변형된 올리고뉴클레오타이드는 20 개의 연결된 뉴클레오사이드로 이루어진다.
특정 구현예에서, 변형된 올리고뉴클레오타이드는 19 개의 연결된 뉴클레오사이드로 이루어진다.
특정 구현예에서, 변형된 올리고뉴클레오타이드는 18 개의 연결된 뉴클레오사이드로 이루어진다.
특정 구현예는 본원에 개시된 임의의 화합물 또는 이의 염, 및 약제학적으로 허용가능한 담체 또는 희석제 중 적어도 하나를 포함하는 조성물을 제공한다.
특정 구현예는 본원에 기재된 바와 같은 임의의 화합물 또는 조성물을 동물에게 투여하는 단계를 포함하는 방법을 제공한다.
특정 구현예에서, 상기 동물은 인간이다.
특정 구현예에서, 상기 화합물의 투여는 타우 연관된 질환, 장애 또는 병태를 예방, 치료, 개선 또는 이의 진행을 지연시키는, 방법.
특정 구현예에서, 상기 질환, 장애, 또는 병태는 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 또는 드라벳 증후군이다.
특정 구현예는 신경퇴행성 장애를 치료하기 위한 약제의 제조를 위한, 본원에 개시된 화합물 또는 조성물의 용도를 제공한다.
특정 구현예는 하기 화학식 (Ia)에 따른 화합물 또는 이들의 약학적으로 허용가능한 염을 제공한다:
특정 구현예에서, 상기 화학식 (Ia)를 갖는 화합물을 포함하는 약제학적 조성물이 제공된다.
특정 구현예는 하기 화학식 (IIa)에 따른 화합물 또는 이들의 약학적으로 허용가능한 염을 제공한다:
특정 구현예에서, 상기 화학식 (IIa)를 갖는 화합물을 포함하는 약제학적 조성물이 제공된다.
특정 구현예는 하기 화학식 (IIIa)에 따른 화합물 또는 이들의 약학적으로 허용가능한 염을 제공한다.
특정 구현예에서, 상기 화학식 (IIIa)를 갖는 화합물을 포함하는 약제학적 조성물이 제공된다.
특정 구현예는 하기 화학식 (IVa)에 따른 화합물 또는 이들의 약학적으로 허용가능한 염을 제공한다.
특정 구현예에서, 상기 화학식 (IVa)를 갖는 화합물을 포함하는 약제학적 조성물이 제공된다.
특정 구현예는 하기 화학식 (Va)에 따른 화합물 또는 이들의 약학적으로 허용가능한 염을 제공한다:
특정 구현예에서, 상기 화학식 (Va)를 갖는 화합물을 포함하는 약제학적 조성물이 제공된다.
안티센스 화합물
올리고머 화합물은, 비제한적으로, 올리고뉴클레오타이드, 올리고뉴클레오사이드, 올리고뉴클레오타이드 유사체, 올리고뉴클레오타이드 모방체, 안티센스 화합물, 안티센스 올리고뉴클레오타이드, 및 siRNA를 포함한다. 올리고머 화합물은 표적 핵산에 대한 "안티센스"일 수 있고, 이것은 수소 결합을 통해 표적 핵산에 대한 혼성화를 경험할 수 있다는 것을 의미한다.
특정 구현예에서, 안티센스 화합물은, 5'에서 3' 방향으로 쓰여질 때, 그것이 표적화된 표적 핵산의 표적 분절의 역보체를 포함하는 핵염기 서열을 갖는다. 그와 같은 특정 구현예에서, 안티센스 올리고뉴클레오타이드는, 5'에서 3' 방향으로 쓰여질 때, 그것이 표적화된 표적 핵산의 표적 분절의 역보체를 포함하는 핵염기 서열을 갖는다.
특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 12 내지 30 개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 12 내지 25 개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 12 내지 22 개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 14 내지 20 개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 15 내지 25 개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 18 내지 22 개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 19 내지 21 개의 하부단위이다. 특정 구현예에서, 안티센스 화합물은 길이가 8 내지 80개, 12 내지 50개, 13 내지 30개, 13 내지 50개, 14 내지 30개, 14 내지 50개, 15 내지 30개, 15 내지 50개, 16 내지 30개, 16 내지 50개, 17 내지 30개, 17 내지 50개, 18 내지 30개, 18 내지 50개, 19 내지 30개, 19 내지 50개, 또는 20 내지 30개 연결된 하부단위이다.
특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 12개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 13개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 14개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 15개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 16개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 17개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 18개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 19개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 20개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 21개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 22개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 23개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 24개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 25개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 26개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 27개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 28개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 29개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 30개의 하부단위이다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 그 길이가 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 또는 80개 연결된 하부단위 또는 상기 값 중 임의의 2개에 의하여 정의된 범위 내이다. 특정 구현예에서, 안티센스 화합물은 안티센스 올리고뉴클레오타이드이고, 상기 연결된 하부단위는 뉴클레오사이드이다.
특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 단축되거나 절단될 수 있다. 예를 들어, 단일 하부단위는 5' 말단 (5' 절단), 또는 대안적으로 3' 말단 (3' 절단)로부터 결실될 수 있다. 타우 핵산에 표적화된 단축된 또는 절단된 안티센스 화합물은 상기 안티센스 화합물의 5' 말단으로부터 결실된 2 개의 하부단위를 가질 수 있고, 또는 대안적으로 이의 3' 말단으로부터 결실된 2개의 하부단위를 가질 수 있다. 대안적으로, 결실된 뉴클레오사이드는 안티센스 화합물을 통하여, 예를 들면, 5' 말단으로부터 결실된 하나의 뉴클레오사이드 및 3' 말단로부터 결실된 하나의 뉴클레오사이드을 갖는 안티센스 화합물에서, 분산될 수 있다.
단일 부가적 하부단위가 늘어난 안티센스 화합물에 존재할 때, 부가적 하부단위는 안티센스 화합물의 5' 또는 3' 말단에서 위치할 수 있다. 2 개 이상의 부가적 하부단위가 존재할 때, 부가된 뉴클레오사이드는, 예를 들면, 안티센스 화합물의 5' 말단 (5' 부가), 또는 대안적으로 3' 말단 (3' 부가)에 부가된 2개의 하부단위를 갖는 안티센스 화합물에서 서로 인접할 수 있다. 대안적으로, 부가된 하부단위는 안티센스 화합물을 통하여, 예를 들면, 5' 말단에 부가된 하나의 하부단위 및 3' 말단에 부가된 하나의 하부단위를 갖는 안티센스 화합물에서 분산될 수 있다.
안티센스 화합물, 예컨대 안티센스 올리고뉴클레오타이드의 길이를 증가 또는 감소시키고/거나 활성을 제거하지 않으면서 미스매치 염기를 도입하는 것이 가능하다. 예를 들어, 다음을 참고: Woolf et al. (Proc. Natl. Acad. Sci. USA 89:7305-7309, 1992), 일련의 길이가 13-25개의 핵염기인 안티센스 올리고뉴클레오타이드가 난모세포 주사 모델에서 표적 RNA의 절단을 유도하는 그들의 능력에 대해 시험되었다. 안티센스 올리고뉴클레오타이드의 말단 근처의 8 또는 11 미스매치 염기를 가지며 그 길이가 25개 핵염기인 안티센스 올리고뉴클레오타이드는 미스매치를 함유하지 않는 안티센스 올리고뉴클레오타이드보다 더 적을지라도 표적 mRNA의 직접적인 특이적 절단이 가능했다. 마찬가지로, 표적 특이적 절단은 1 또는 3 미스매치를 갖는 것을 포함하는 13개 핵염기 안티센스 올리고뉴클레오타이드를 사용하여 달성되었다.
Gautschi et al (J.Natl. Cancer Inst. 93:463-471, March 2001)는 bcl-2 및 bcl-xL 둘 다의 시험관내 및 체내 발현을 감소시키기 위해 bcl-2 mRNA에 대해100% 상보성을 가지며 bcl-xL mRNA에 대한 3 개의 미스매치를 갖는 올리고뉴클레오타이드의 능력을 실증했다. 더욱이, 이러한 올리고뉴클레오타이드는 체내 강력한 항-종양 활성을 실증했다.
Maher 및 Dolnick (Nuc. Acid. Res. 16:3341-3358,1988) 는 토끼 망상적혈구 검정에서 인간 DHFR의 번역을 저지하는 그것의 능력에 대한, 각각의 탠덤 안티센스 올리고뉴클레오타이드의 2개 또는 3개 서열로 구성된, 일련의 탠덤 14 핵염기 안티센스 올리고뉴클레오타이드 및, 28 및 42 핵염기 안티센스 올리고뉴클레오타이드를 시험했다. 각각의 3 개의 14 핵염기 안티센스 올리고뉴클레오타이드 단독은 28 또는 42 핵염기 안티센스 올리고뉴클레오타이드보다 더 보통의 수준일지라로 번역을 억제할 수 있었다.
안티센스 화합물 모티프
특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 안티센스 화합물 특성 예컨대 증대된 억제 활성, 증가된 표적 핵산에 대한 결합 친화도, 또는 체내 뉴클레아제에 의한 분해에 대한 내성을 부여하기 위해 패턴, 또는 모티프에서 배열된 화학적으로 변형된 하부단위를 갖는다.
키메라 안티센스 화합물은 전형적으로 뉴클레아제 분해에 대한 증가된 내성, 증가된 세포 흡수, 표적 핵산의 증가된 결합 친화도, 및/또는 증가된 억제 활성을 부여하기위해 변형된 적어도 하나의 영역을 함유한다. 키메라 안티센스 화합물의 제 2 영역은 RNA:DNA 듀플렉스의 RNA 가닥을 절단하는 세포 엔도뉴클레아제 RNase H의 기질로서 임의로 쓰일 수 있다.
갭머 모티프를 갖는 안티센스 화합물은 키메라 안티센스 화합물로 간주된다. 갭머에서 RNaseH 절단을 지지하는 복수의 뉴클레오타이드를 갖는 내부 영역은 내부 영역의 뉴클레오사이드로부터 화학적으로 뚜렷한 복수의 뉴클레오타이드를 갖는 외부 영역 사이에 배치된다. 갭머 모티프를 갖는 안티센스 올리고뉴클레오타이드의 경우에, 갭 분절은 일반적으로 엔도뉴클레아제 절단의 기질로서 쓰이지만, 윙 분절은 변형된 뉴클레오사이드를 포함한다. 특정 구현예에서, 갭머의 영역은 각각의 뚜렷한 영역을 포함하는 당 모이어티의 유형에 의해 분화된다. 갭머의 영역을 분화시키기 위해 사용된 당 모이어티의 유형은 일부 구현예에서 하기를 포함할 수 있다: β-D-리보뉴클레오사이드, β-D-데옥시리보뉴클레오사이드, 2'-변형된 뉴클레오사이드 (그와 같은 2'-변형된 뉴클레오사이드는 기타 중에서 2'-MOE 및 2'-O-CH3를 포함할 수 있다), 및 이환식 당 변형된 뉴클레오사이드 (그와 같은 이환식 당 변형된 뉴클레오사이드는 4'-(CH2)n-O-2' 가교(여기서 n=1 또는 n=2 및 4'-CH2-O-CH2-2')을 갖는 것을 포함할 수 있다). 특정 구현예에서, 윙은, 예를 들면 2'-MOE 및 제한된 에틸을 포함하는 몇 개의 변형된 당 모이어티를 포함할 수 있다. 특정 구현예에서, 윙은 몇 개의 변형된 및 비변형된 당 모이어티를 포함할 수 있다. 특정 구현예에서, 윙은 2'-MOE 뉴클레오사이드, 및 2'-데옥시뉴클레오사이드의 다양한 조합을 포함할 수 있다.
각각의 뚜렷한 영역은 균일한 당 모이어티, 변이체, 또는 교차 당 모이어티를 포함할 수 있다. 윙-갭-윙 모티프는 "X-Y-Z"로서 빈번히 기재되고, 여기서 "X"는 5'-윙의 길이를 나타내고, "Y"는 갭의 길이를 나타내고, 그리고 "Z"는 3'-윙의 길이를 나타낸다. "X" 및 "Z"는 균일한, 변이체, 또는 교대 당 모이어티를 포함할 수 있다. 특정 구현예에서, "X" 및 "Y"는 하나 이상의 2'-데옥시뉴클레오사이드를 포함할 수 있다. "Y"는 2'-데옥시뉴클레오사이드를 포함할 수 있다. 본원에서 사용된 바와 같이, "X-Y-Z"로서 기재된 갭머는, 갭이 각각의 5'-윙 및 3' 윙에 바로 인접하여 배치되는 정도의 배치를 갖는다. 따라서, 개재(intervening) 뉴클레오타이드는 5'-윙 및 갭, 또는 갭 및 3'-윙 사이에 존재하지 않는다. 본원에 기재된 안티센스 화합물의 임의의 것은 갭머 모티프를 가질 수 있다. 특정 구현예에서, "X" 및 "Z"는 동일하고, 다른 구현예에서는 상이하다.
특정 구현예에서, 본원에 제공된 갭머는 예를 들어 5-10-5의 모티프를 갖는 20 량체(20 - mers)를 포함한다.
특정 구현예에서, 본원에 제공된 갭머는 예를 들어 5-9-5의 모티프를 갖는 19량체(19 - mers)를 포함한다.
특정 구현예에서, 본원에 제공된 갭머는 예를 들어 5-8-5의 모티프를 갖는 18량체(18-mers)를 포함한다.
특정 구현예에서, 본원에 제공된 갭머는 예를 들어 4-8-6의 모티프를 갖는 18량체(18-mers)를 포함한다.
특정 구현예에서, 본원에 제공된 갭머는 예를 들어 6-8-4의 모티프를 갖는 18량체(18-mers)를 포함한다.
특정 구현예에서, 본원에 제공된 갭머는 예를 들어 5-7-6의 모티프를 갖는 18량체(18-mers)를 포함한다.
표적 핵산, 표적 영역 및 뉴클레오타이드 서열
타우를 암호화하는 뉴클레오타이드 서열은 비제한적으로 하기를 포함한다: 뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 NT_010783.15 (본원에서 서열 번호: 1과 같이 포함) 유전자 은행 수탁 번호 NM_001123066.3 (본원에서 서열 번호: 2와 같이 포함) 엑손 3, 4, 6, 8, 10, 및 12를 건너뛰는 유전자 은행 수탁 번호 NM_016841.4, 변이체 mRNA 서열 (본원에서 서열 번호: 3과 같이 포함) 뉴클레오타이드 2624000-2761000로부터 절단된 유전자 은행 수탁 번호 NT_010783.14 (본원에서 서열 번호: 4와 같이 포함) 유전자 은행 수탁 번호 DR002467.1 (본원에서 서열 번호: 5와 같이 포함) 유전자 은행 수탁 번호 NM_001203251.1 (본원에서 서열 번호: 6과 같이 포함) 및 유전자 은행 수탁 번호 NM_016835.4 (본원에서 서열 번호: 7과 같이 포함).
본원에 함유된 실시예에서 각각의 서열 번호로 제시된 서열은 당 모이어티, 뉴클레오사이드간 연결, 또는 핵염기에 대한 임의의 변형에 독립적인 것으로 이해된다. 그것으로서, 서열번호에 의해 규정된 안티센스 화합물은 당 모이어티, 뉴클레오사이드간 연결, 또는 핵염기에 대한 하나 이상의 변형을 독립적으로 포함할 수 있다. ISIS 번호 (Isis No)에 의해 기재된 안티센스 화합물은 핵염기 서열 및 모티프의 조합을 나타낸다.
특정 구현예에서, 표적 영역은 표적 핵산의 구조적으로 규정된 영역이다. 예를 들면, 표적 영역은 3' UTR, 5' UTR, 엑손, 인트론, 엑손/인트론 접합, 암호화 영역, 번역 개시 영역, 번역 종료 영역, 또는 다른 규정된 핵산 영역을 포괄할 수 있다. 타우에 대한 구조적으로 규정된 영역은 서열 데이타베이스 예컨대 NCBI로부터의 승인 번호에 의해 수득될 수 있고 그와 같은 정보는 본원에 참고로 포함되어 있다. 특정 구현예에서, 표적 영역은 표적 영역내의 하나의 표적 분절의 5' 표적 부위로부터 동일한 표적 영역내의 다른 표적 분절의 3' 표적 부위까지의 서열을 포괄할 수 있다.
표적화는 안티센스 화합물이 혼성화하는 적어도 하나의 표적 분절의 결정을 포함하고, 이로써 원하는 효과가 발생한다. 특정 구현예에서, 원하는 효과는 mRNA 표적 핵산 수준의 감소이다. 특정 구현예에서, 원하는 효과는 표적 핵산 또는 표적 핵산과 연관된 표현형 변화에 의해 암호화된 단백질의 수준의 감소이다.
표적 영역은 하나 이상의 표적 분절을 함유할 수 있다. 표적 영역 내의 다중 표적 분절은 중복일 수 있다. 대안적으로, 이들은 비-중복일 수 있다. 특정 구현예에서, 표적 영역 내의 표적 분절은 약 300개 이하의 뉴클레오타이드에 의해 분리된다. 특정 구현예에서, 표적 영역 내의 표적 분절은 표적 핵산 상의 약 250, 200, 150, 100, 90, 80, 70, 60, 50, 40, 30, 20, 또는 10 또는 그 이하의 뉴클레오타이드이고, 이전의 값의 임의의 2개에 의해 규정된 범위인 수많은 뉴클레오타이드에 의해 분리된다. 특정 구현예에서, 표적 영역 내의 표적 분절은 표적 핵산 상의 약 5개 이하의 뉴클레오타이드에 의해 분리된다. 특정 구현예에서, 표적 분절은 인접한다. 본원에서 열거된 5' 표적 부위 또는 3' 표적 부위의 임의의 것인 개시 핵산을 갖는 범위에 의해 규정된 표적 영역이 고려된다.
적당한 표적 분절은 5' UTR, 암호화 영역, 3' UTR, 인트론, 엑손, 또는 엑손/인트론 접합 내에서 발견될 수 있다. 시작 코돈 또는 정지 코돈을 함유하는 표적 분절은 또한 적당한 표적 분절이다. 적당한 표적 분절은 특정의 구조적으로 규정된 영역 예컨대 시작 코돈 또는 정지 코돈을 명시적으로 제외할 수 있다.
적당한 표적 분절의 결정은 게놈 도처의 다른 서열에 대한 표적 핵산의 서열의 비교를 포함할 수 있다. 예를 들면, BLAST 알고리즘은 상이한 핵산 중에서 유사성의 영역을 확인하기 위해 사용될 수 있다. 이러한 비교는 선택된 표적 핵산 이외의 서열 (즉, 비-표적 또는 오프-타겟(off-target) 서열)과 비특이적 방식으로 혼성화할 수 있는 안티센스 화합물의 서열의 선택을 방지할 수 있다
활성 표적 영역 내의 안티센스 화합물의 활성의 변화 (예를 들면, 표적 핵산 수준의 퍼센트 감소에 의해 규정된 바와 같이) 가 있을 수 있다. 특정 구현예에서, 타우 mRNA 수준의 감소는 타우 발현의 억제를 가리킨다. 타우 단백질의 수준 감소는 또한 표적 mRNA 발현의 억제를 가리킨다. 과인산화된 타우에 대한 세포 염색 양성 백분율의 감소는 타우 발현의 억제를 가리킨다. 더욱이, 표현형 변화는 타우 발현의 억제를 가리킨다. 신경학적 기능에서의 개선은 타우 발현의 억제를 가리킨다. 기억 및 운동 기능에서의 개선은 타우 발현의 억제를 가리킨다. 신경섬유 포함물의 감소는 타우 발현의 억제를 가리킨다.
혼성화
일부 구현예에서, 혼성화는 본원에 개시된 안티센스 화합물 및 타우 핵산 사이에서 발생한다. 혼성화의 가장 일반적인 기전은 핵산 분자의 상보적 핵염기 사이의 수소 결합 (예를 들면, 왓슨-크릭(Watson-Crick), 후그스텐(Hoogsteen) 또는 역전된 후그스텐(Hoogsteen) 수소 결합)을 수반한다.
혼성화는 가변 조건 하에서 발생할 수 있다. 엄격한 조건은 서열-의존적이고 혼성화될 핵산 분자의 성질 및 조성에 의해 결정된다.
서열이 표적 핵산과 특이적으로 혼성화할 수 있는 지를 측정하는 방법은 당해기술에 공지되어 있다. 특정 구현예에서, 본원에서 제공된 안티센스 화합물은 타우 핵산과 특이적으로 혼성화할 수 있다.
상보성
안티센스 화합물 및 표적 핵산은, 충분한 수의 안티센스 화합물의 핵염기가 표적 핵산의 상응하는 핵염기와 수소연결하여 이로써 원하는 효과가 발생할 수 있을 때 (예를 들면, 표적 핵산, 예컨대 타우 핵산의 안티센스 억제), 서로 상보적이다.
안티센스 화합물 및 타우 핵산 사이에서의 비-상보적 핵염기는, 상기 안티센스 화합물이 표적 핵산에 특이적으로 혼성화 가능하도록 남아있는 경우 용인될 수 있다. 더욱이, 안티센스 화합물은 타우 핵산의 하나 이상의 분절 상에서 혼성화될 수 있고 이로써 개재 또는 인접한 분절은 혼성화 사건 (예를 들면, 루프 구조, 미스매치 또는 헤어핀 구조)에 관여하지 않는다.
특정 구현예에서, 본원에서 제공된 안티센스 화합물, 또는 명시된 이의 부분은 타우 핵산, 표적 영역, 표적 분절, 또는 명시된 이의 부분에 대해 적어도, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 또는 100% 상보적이다. 표적 핵산을 갖는 안티센스 화합물의 퍼센트 상보성은 보통의 방법을 사용하여 측정될 수 있다.
예를 들면, 20개 안티센스 화합물의 핵염기 중 18개는 표적 영역에 대해 상보적이고 따라서 특이적으로 혼성화하는, 안티센스 화합물은 90 퍼센트 상보성을 나타낼 것이다. 이러한 예시에서, 잔류 비-상보적 핵염기는 무리를 이루거나 상보적 핵염기와 함께 사이에 배치될 수 있고, 서로 또는 상보적 핵염기에 인접할 필요가 없다. 그것으로서, 표적 핵산에 완전한 상보성을 갖는 2 개의 영역에 의해 플랭킹된 4 개의 비-상보적 핵염기를 갖는 길이가 18개의 핵염기인 안티센스 화합물은 표적 핵산에 77.8% 전체 상보성을 가질 것이며, 따라서 본 발명의 범위 내에 있을 것이다. 표적 핵산의 영역을 갖는 안티센스 화합물의 퍼센트 상보성은 당해기술에서 공지된 BLAST 프로그램 (기본적 국소 정렬 연구 도구) 및 PowerBLAST 프로그램을 사용하여 보통 측정될 수 있다 (Altschul 등, J. Mol. Biol., Biol., 1990, 215, 403 410; Zhang 및 Madden, Genome Res., 1997, 7, 649 656). 퍼센트 상동성, 서열 동일성 또는 상보성은 Smith 및 Waterman (Adv. Appl. Math., 1981, 2, 482 489)의 알고리즘을 사용하는 디폴트 세팅을 사용하여, 예를 들면, Gap 프로그램 (Wisconsin Sequence Analysis Package, Version 8 for Unix, Genetics Computer Group, University Research Park, Madison Wis.)에 의해 측정될 수 있다.
특정 구현예에서, 본원에서 제공된 안티센스 화합물, 또는 이의 명시된 부분은 표적 핵산, 또는 명시된 이의 부분에 대해 완전 상보적 (즉, 100% 상보적)이다. 예를 들면, 안티센스 화합물은 타우 핵산, 또는 이의 표적 영역, 또는 표적 분절 또는 표적 서열에 대해 완전히 상보적일 수 있다. 본원에서 사용된 바와 같이, "완전히 상보적"은, 안티센스 화합물의 각각의 핵염기가 표적 핵산의 상응하는 핵염기와 정확한 염기 짝짓기를 할수 있다는 것을 의미한다. 예를 들면, 20 핵염기 안티센스 화합물은, 안티센스 화합물에 대해 완전히 상보적인 표적 핵산의 상응하는 20 핵염기 부분이 있는 한, 400 핵염기 길이인 표적 서열에 대해 완전히 상보적이다. 완전 상보성은 제 1 및/또는 제 2 핵산의 명시된 부분을 참조하여 또한 사용될 수 있다. 예를 들면, 30 핵염기 안티센스 화합물의 20 핵염기 부분은 400개 핵염기 길이인 표적 서열에 대해 "완전히 상보적"일 수 있다. 30 핵염기 올리고뉴클레오타이드의 20 핵염기 부분은, 표적 서열이 상응하는 20 핵염기 부분을 갖고, 이때 각각의 핵염기가 안티센스 화합물의 20 핵염기 부분에 대해 상보적이라면, 표적 서열에 대해 완전히 상보적이다. 동시에, 전체 30 핵염기 안티센스 화합물은, 안티센스 화합물의 잔류 10 핵염기가 표적 서열에 대해 또한 상보적인지에 따라 표적 서열에 대해 또한 완전히 상보적이거나 그렇지 않을 수 있다.
비-상보적 핵염기의 위치는 안티센스 화합물의 5' 말단 또는 3' 말단에 있을 수 있다. 대안적으로, 비-상보적 핵염기 또는 핵염기들은 안티센스 화합물의 내부 위치에 있을 수 있다. 두개 이상의 비-상보적 핵염기가 존재할 때, 이들은 인접하거나(즉, 연결되거나), 또는 비-인접할 수 있다. 일 구현예에서, 비-상보적 핵염기는 갭머 안티센스 올리고뉴클레오타이드의 윙 분절에 위치한다.
특정 구현예에서, 길이가 11, 12, 13, 14, 15, 16, 17, 18, 19, 또는 20개이거나, 또는 최대로 상기 길이인 안티센스 화합물은 표적 핵산, 예컨대 타우 핵산, 또는 명시된 이의 부분에 대해 4 이하, 3 이하, 2 이하, 또는 1 이하의 비-상보적 핵염기(들)을 포함한다.
특정 구현예에서, 길이가 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 또는 30개이거나, 또는 최대로 상기 길이인 안티센스 화합물은 표적 핵산, 예컨대 타우 핵산, 또는 명시된 이의 부분에 대해 6 이하, 5 이하, 4 이하, 3 이하, 2 이하, 또는 1 이하의 비-상보적 핵염기(들)을 포함한다.
본원에서 제공된 안티센스 화합물은 또한 표적 핵산의 부분에 대해 상보적인 것을 포함한다. 본원에서 사용된 바와 같이, "부분"은 표적 핵산의 영역 또는 분절 내의 규정된 수의 인접한 (즉, 연결된) 핵염기를 의미한다. "부분"은 또한 규정된 수의 안티센스 화합물의 인접한 핵염기를 의미할 수 있다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 8 핵염기 부분에 대해 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 9 핵염기 부분에 대해 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 10 핵염기 부분에 대해 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 11 핵염기 부분에 대해 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 12 핵염기 부분에 대해 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 13 핵염기 부분에 대해 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 14 핵염기 부분에 대해 상보적이다. 특정 구현예에서, 안티센스 화합물은 표적 분절의 적어도 15 핵염기 부분에 대해 상보적이다. 표적 분절의 적어도 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 또는 그 초과, 또는 이들 값의 임의의 2 개에 의해 규정된 범위의 핵염기 부분에 대해 상보적인 안티센스 화합물이 또한 고려된다.
동일성
본원에서 제공된 안티센스 화합물은 특정한 뉴클레오타이드 서열, 서열번호, 또는 특정 ISIS 번호로 나타내는 화합물, 또는 이의 부분에 대한 규정된 퍼센트 동일성을 또한 가질 수 있다. 본원에서 사용된 바와 같이, 안티센스 화합물은, 동일한 핵염기 짝짓기 능력을 갖는다면, 본원에 개시된 서열과 동일하다. 예를 들면, 우라실 및 티미딘 둘 다 아데닌과 쌍을 이루므로, 개시된 DNA 서열에서 티미딘 대신에 우라실을 함유하는 RNA가 DNA 서열과 동일한 것으로 간주된다. 본원에 기재된 안티센스 화합물 뿐만 아니라 본원에서 제공된 안티센스 화합물에 대해 비-동일한 염기를 갖는 화합물의 단축된 및 늘어난 버전이 또한 고려된다. 비-동일한 염기는 안티센스 화합물에 도처에서 분산되거나 서로 인접할 수 있다. 안티센스 화합물의 퍼센트 동일성은 비교되는 서열에 대해 동일한 염기 짝짓기를 갖는 염기의 수에 따라 산출된다.
특정 구현예에서, 안티센스 화합물, 또는 이의 일부는, 본원에 개시된 안티센스 화합물 또는 서열번호, 또는 이의 부분의 하나 이상과 적어도 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% 또는 100% 동일하다.
특정 구현예에서, 안티센스 화합물의 부분은 표적 핵산의 동등한 길이 부분과 비교된다. 특정 구현예에서, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 또는 25 핵염기 부분은 표적 핵산 부분과 동등한 길이 부분과 비교된다.
특정 구현예에서, 안티센스 올리고뉴클레오타이드의 부분은 표적 핵산 부분과 동등한 길이 부분과 비교된다. 특정 구현예에서, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 또는 25 핵염기 부분은 표적 핵산 부분과 동등한 길이 부분과 비교된다.
변형
뉴클레오사이드는 염기-당 조합이다. 뉴클레오사이드의 핵염기 (또한 염기로서 공지됨) 부분은 보통 헤테로환 염기 모이어티이다. 뉴클레오타이드는 뉴클레오사이드의 당 부분에 공유 연결된 인산기를 추가로 포함하는 뉴클레오사이드이다. 펜토푸라노실 당을 포함하는 뉴클레오사이드에 대해, 인산기는 당의 2', 3' 또는 5' 하이드록실 모이어티에 연결될 수 있다. 올리고뉴클레오타이드는 서로에 대한 인접한 뉴클레오사이드의 공유연결을 통해 형성되어, 선형 중합체 올리고뉴클레오타이드를 형성한다. 올리고뉴클레오타이드 구조 내에, 인산기는 통상적으로 올리고뉴클레오타이드의 뉴클레오사이드간 연결을 형성하는 것으로 간주된다.
안티센스 화합물에 대한 변형은 뉴클레오사이드간 연결, 당 모이어티, 또는 핵염기에 대한 치환 또는 변화를 포괄한다. 변형된 안티센스 화합물은 바람직한 특성 예컨대, 예를 들면, 증대된 세포 흡수, 핵산 표적에 대한 증대된 친화도, 뉴클레아제의 존재에서의 증가된 안정성, 또는 증가된 억제 활성 때문에 원산 형태와 비교하여 종종 바람직하다.
화학적으로 변형된 뉴클레오사이드는 그것의 표적 핵산에 대해, 단축된 또는 절단된 안티센스 올리고뉴클레오타이드의 결합 친화도를 증가시키기 위해 또한 이용될 수 있다. 결과적으로, 비교할만한 결과는 그와 같은 화학적으로 변형된 뉴클레오사이드를 갖는 더 짧은 안티센스 화합물로 종종 수득될 수 있다.
변형된 뉴클레오사이드간 연결
RNA 및 DNA의 "천연적으로 발생하는 뉴클레오사이드간 연결"은 3' 내지 5' 포스포디에스테르 연결을 의미한다. 하나 이상의 변형된, 즉 비-천연 발생, 뉴클레오사이드간 연결을 갖는 안티센스 화합물은 바람직한 특성 예컨대, 예를 들면, 증대된 세포 흡수, 표적 핵산에 대한 증대된 친화도, 및 뉴클라아제의 존재에서 증가된 안정성 때문에 천연 발생 뉴클레오사이드간 연결을 갖는 안티센스 화합물과 비교하여 종종 선택된다.
변형된 뉴클레오사이드간 연결을 갖는 올리고뉴클레오타이드는 인 원자를 보유하는 뉴클레오사이드간 연결 뿐만 아니라 인 원자를 갖지 않는 뉴클레오사이드간 연결을 포함한다. 대표적인 인을 함유하는 뉴클레오사이드간 연결은, 비제한적으로, 포스포디에스테르, 포스포트리에스테르, 메틸포스포네이트, 포스포르아미데이트, 및 포스포로티오에이트를 포함한다. 인-함유 및 비-인-함유 연결의 제조 방법은 공지되어 있다.
특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물은 하나 이상의 변형된 뉴클레오사이드간 연결을 포함한다. 특정 구현예에서, 변형된 뉴클레오사이드간 연결은 안티센스 화합물 도처에 배치된다. 특정 구현예에서, 변형된 뉴클레오사이드간 연결은 포스포로티오에이트 연결이다. 특정 구현예에서, 안티센스 화합물의 각 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결이다.
변형된 당 모이어티
안티센스 화합물은 하나 이상의 뉴클레오사이드를 함유할 수 있으며, 여기서 당 그룹은 변형되었던 것이다. 그와 같은 당 변형된 뉴클레오사이드는 안티센스 화합물에 대한 증대된 뉴클레아제 안정성, 증가된 결합 친화도, 또는 일부 다른 유익한 생물학적 특성을 부여할 수 있다. 특정 구현예에서, 뉴클레오사이드는 화학적으로 변형된 리보푸라노스 환 모이어티를 포함한다. 화학적으로 변형된 리보푸라노스 고리의 예는 비제한적으로 하기를 포함한다: 치환체 그룹의 부가 (5' 및 2' 치환체 그룹, 이확신 핵산 (BNA)를 형성하기 위한 비-제미널(geminal) 고리 원자의 가교, 리보실 환 산소 원자의 S, N(R), 또는 C(R1)(R2)로의 교체 포함) (R, R1 및 R2 각각은 독립적으로 H, C1-C12 알킬 또는 보호기로부터 선택된다) 및 이들의 조합. 화학적으로 변형된 당의 예시는 하기를 포함한다: 2'-F-5'-메틸 치환된 뉴클레오사이드 (참고, PCT 국제 출원 WO 2008/101157, 다른 개시된 5', 2'-비스 치환된 뉴클레오사이드에 대해 8/21/08에 공개됨), 또는 2'-위치에서 추가 치환에 의해 S에 의한 리보실 환 산소 원자의 교체 (참고, 공개된 미국 특허 출원 US2005/0130923, 2005년 6월 16일에 공개됨), 또는 대안적으로, BNA의 5'-치환 (참고, PCT 국제 출원 WO 2007/134181, 11/22/07에 공개됨, LNA는, 예를 들면, 5'-메틸 또는 5'-비닐 그룹으로 치환됨).
변형된 당 모이어티를 갖는 뉴클레오사이드의 예는 5'-비닐, 5'-메틸 (R 또는 S), 4'-S, 2'-F, 2'-OCH3, 2'-OCH2CH3, 2'-OCH2CH2F 및 2'-O(CH2)2OCH3 치환체 그룹을 포함하는 뉴클레오사이드를 비제한적으로 포함한다. 2' 위치에서의 치환체는 알릴, 아미노, 아지도, 티오, O-알릴, O-C1-C10 알킬, OCF3, OCH2F, O(CH2)2SCH3, O(CH2)2-O-N(Rm)(Rn), O-CH2-C(=O)-N(Rm)(Rn), 및 O-CH2-C(=O)-N(Rl)-(CH2)2-N(Rm)(Rn), 여기서 각각의 Rl, Rm 및 Rn은 독립적으로, H 또는 치환된 또는 비치환된 C1-C10 알킬이다.
본원에서 사용된 바와 같이, "이환식 뉴클레오사이드"는 이환식 당 모이어티를 포함하는 변형된 뉴클레오사이드를 지칭한다. 이환식 뉴클레오사이드의 예는 4' 및 2' 리보실 환 원자 사이의 가교를 포함하는 뉴클레오사이드를 비제한적으로 포함한다. 특정 구현예에서-, 본원에서 제공된 안티센스 화합물은 4' 내지 2' 이환식 가교를 포함하는 하나 이상의 이환식 뉴클레오사이드를 포함한다. 그와 같은 4' 내지 2' 이환식 뉴클레오사이드의 하기 식 중의 하나를 비제한적으로 포함한다: 4'-(CH2)-O-2' (LNA); 4'-(CH2)-S-2'; 4'-(CH2)2-O-2' (ENA); 4'-CH(CH3)--O-2' 및 4'-C-H(CH2OCH3)--O-2' 및 그의 유사체 (참고, 미국 특허 7,399,845, 2008년 7월 15일 발표); 4'-C(CH3)(CH3)--O-2' 및 그의 유사체 (참고, 공개된 PCT 국제 출원 WO2009/006478, 2009년 1월 8일 공개); 4'-CH2-N(OCH3)-2' 및 그의 유사체 (참고, 공개된 PCT 국제 출원 WO2008/150729, 2008년 12월 11일 공개); 4'-CH2-O-N(CH3)-2' (참고, 공개된 미국 특허 출원 US2004/0171570, 2004년 9월 2일 공개); 4'-CH2-N(R)-O-2' (여기서 R은 H, C1-C12 알킬, 또는 보호기이다) (참고, 미국 특허 7,427,672, 2008년 12월 23일 발표); 4'-CH2-C-(H)(CH3)-2' (참고, Chattopadhyaya et al., J. Org. Chem., 2009, 74, 118-134); 및 4'-CH2-C-(=CH2)-2' (및 이의 유사체, 참고: 공개 국제 출원 WO 2008/154401, 2008년 12월 8일 발표).
이환식 뉴클레오타이드와 관련된 추가적인 보고는 다음 출판 문헌에서 발견될 수 있다 (예를 들어 Singh et al., Chem. Commun., 1998, 4, 455-456; Koshkin et al., Tetrahedron, 1998, 54, 3607-3630; Wahlestedt et al., Proc. Natl. Acad. Sci. U. S. A., 2000, 97, 5633-5638; Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8, 2219-2222; Singh et al., J. Org. Chem., 1998, 63, 10035-10039; Srivastava et al., J. Am. Chem. Soc., 2007, 129(26) 8362-8379; Elayadi et al., Curr. Opinion Invest. Drugs, 2001, 2, 558-561; Braasch et al., Chem. Biol., 2001, 8, 1-7; 및 Orum et al., Curr. Opinion Mol. Ther., 2001, 3, 239-243; 미국 특허 번호 6,268,490; 6,525,191; 6,670,461; 6,770,748; 6,794,499; 7,034,133; 7,053,207; 7,399,845; 7,547,684; 및 7,696,345; 미국 특허 공보 번호 US2008-0039618; US2009-0012281; 미국 특허 일련 번호 60/989,574; 61/026,995; 61/026,998; 61/056,564; 61/086,231; 61/097,787; 및 61/099,844; 공개 PCT 국제 출원 WO 1994/014226; WO 2004/106356; WO 2005/021570; WO 2007/134181; WO 2008/150729; WO 2008/154401; 및 WO 2009/006478. 각각의 상기 이환식 뉴클레오사이드는 예를 들면 α-L-리보푸라노스 및 β-D-리보푸라노스를 포함하는 하나 이상의 입체화학적 당 배치를 갖도록 제조될 수 있다 (참고 PCT 국제 출원 PCT/DK98/00393, WO 99/14226로서 1999년 3월 25일 공개).
특정 구현예에서, BNA 뉴클레오사이드의 이환식 당 모이어티는, 비제한적으로, 펜토푸라노실 당 모이어티의 4' 및 2' 위치 사이의 적어도 하나의 가교를 갖는 화합물을 포함하고, 여기서 그와 같은 가교는 독립적으로, -[C(Ra)(Rb)]n-, -C(Ra)=C(Rb)-, -C(Ra)=N-, -C(=O)-, -C(=NRa)-, -C(=S)-, -O-, -Si(Ra)2-, -S(=O)x-, 및 -N(Ra)-로부터 독립적으로 선택된 1 또는 2 내지 4 연결된 그룹을 포함한다;
여기서:
x는 0, 1, 또는 2이고;
n은 1, 2, 3, 또는 4이고;
각각의 Ra 및 Rb는, 독립적으로, H, 보호기, 하이드록실, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, 헤테로아릴, 치환된 헤테로아릴, C5-C7 지환족 라디칼, 치환된 C5-C7 지환족 라디칼, 할로겐, OJ1, NJ1J2, SJ1, N3, COOJ1, 아실 (C(=O)-H), 치환된 아실, CN, 설포닐 (S(=O)2-J1), 또는 설폭실 (S(=O)-J1)이고;
각각의 J1 및 J2는, 독립적으로, H, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐,C2-C12 알키닐, 치환된 C2-C12 알키닐, C5-C20 아릴, 치환된 C5-C20 아릴, 아실 (C(=O)-H), 치환된 아실, 헤테로사이클 라디칼, 치환된 헤테로사이클 라디칼, C1-C12 아미노알킬, 치환된 C1-C12 아미노알킬, 또는 보호기이다.
특정 구현예에서, 이환식 당 모이어티의 가교는, -[C(Ra)(Rb)]n-, -[C(Ra)(Rb)]n-O-, -C(RaRb)-N(R)-O- 또는 -C(RaRb)-O-N(R)-이다. 특정 구현예에서, 가교는 4'-CH2-2', 4'-(CH2)2-2', 4'-(CH2)3-2', 4'-CH2-O-2', 4'-(CH2)2-O-2', 4'-CH2-O-N(R)-2' 및 4'-CH2-N(R)-O-2'-이고, 여기서 각각의 R은, 독립적으로, H, 보호기, 또는 C1-C12 알킬이다.
특정 구현예에서, 이환식 뉴클레오사이드는 이성질체 배치에 의해 추가로 규정된다. 예를 들면, 4'-2' 메틸렌-옥시 가교를 포함하는 뉴클레오사이드는, α-L 배치 또는 β-D 배치로 존재한다. 이전에, α-L-메틸렌옥시 (4'-CH2-O-2') BNA'는 안티센스 활성을 보여준 안티센스 올리고뉴클레오타이드에 통합되었다 (Frieden et al., Nucleic Acids Research, 2003, 21, 6365-6372).
특정 구현예에서, 이환식 뉴클레오사이드는, 비제한적으로, (A) α-L-메틸렌옥시 (4'-CH2-O-2') BNA, (B) β-D-메틸렌옥시 (4'-CH2-O-2') BNA, (C) 에틸렌옥시 (4'-(CH2)2-O-2') BNA, (D) 아미노옥시 (4'-CH2-O-N(R)-2') BNA, (E) 옥시아미노 (4'-CH2-N(R)-O-2') BNA, 및 (F) 메틸(메틸렌옥시) (4'-CH(CH3)-O-2') BNA, (G) 메틸렌-티오 (4'-CH2-S-2') BNA, (H) 메틸렌-아미노 (4'-CH2-N(R)-2') BNA, (I) 메틸 카보사이클릭 (4'-CH2-CH(CH3)-2') BNA, 및 (J) 프로필렌 카보사이클릭 (4'-(CH2)3-2') BNA를, 이하에서 묘사된 바와 같이 포함한다.
여기서 Bx는 염기 모이어티이고 R은, 독립적으로, H, 보호기 또는 C1-C12 알킬이다.
특정 구현예에서, 하기 화학식 I을 갖는 이환식 뉴클레오사이드가 제공된다:
여기서:
Bx는 헤테로환 염기 모이어티이고;
-Qa-Qb-Qc-는 -CH2-N(Rc)-CH2-, -C(=O)-N(Rc)-CH2-, -CH2-O-N(Rc)-, -CH2-N(Rc)-O- 또는 -N(Rc)-O-CH2이고;
Rc 는 C1-C12 알킬 또는 아미노 보호기이고; 그리고
Ta 및 Tb 각각은, 독립적으로 H, 하이드록실 보호기, 공액체 그룹, 반응성 인 그룹, 인 모이어티, 또는 지지 매질에 대한 공유 부착(covalent attachment)이다.
특정 구현예에서, 하기 화학식 II을 갖는 이환식 뉴클레오사이드가 제공된다:
여기서:
Bx는 헤테로환 염기 모이어티이고;
Ta 및 Tb 각각은, 독립적으로 H, 하이드록실 보호기, 공액체 그룹, 반응성 인 그룹, 인 모이어티, 또는 지지 매질에 대한 공유 부착(covalent attachment)이고;
Za는 C1-C6 알킬, C2-C6 알케닐, C2-C6 알키닐, 치환된 C1-C6 알킬, 치환된 C2-C6 알케닐, 치환된 C2-C6 알키닐, 아실, 치환된 아실, 치환된 아미드, 티올, 또는 치환된 티오이다.
일 구현예에서, 각각의 치환된 그룹은, 독립적으로, 할로겐, 옥소, 하이드록실, OJc, NJcJd, SJc, N3, OC(=X)Jc, 및 NJeC(=X)NJcJd로부터 독립적으로 선택된 치환체 그룹으로 모노 또는 폴리 치환되고, 여기서 각각의 Jc, Jd 및 Je는, 독립적으로, H, C1-C6 알킬, 또는 치환된 C1-C6 알킬이고 X는 O 또는 NJc이다.
특정 구현예에서, 하기 화학식 III을 갖는 이환식 뉴클레오사이드가 제공된다:
여기서:
Bx는 헤테로환 염기 모이어티이고;
Ta 및 Tb 각각은, 독립적으로 H, 하이드록실 보호기, 공액체 그룹, 반응성 인 그룹, 인 모이어티, 또는 지지 매질에 대한 공유 부착(covalent attachment)이고;
Zb는 C1-C6 알킬, C2-C6 알케닐, C2-C6 알키닐, 치환된 C1-C6 알킬, 치환된 C2-C6 알케닐, 치환된 C2-C6 알키닐, 아실, 또는 치환된 아실 (C(=O)-)이다.
특정 구현예에서, 하기 화학식 IV을 갖는 이환식 뉴클레오사이드가 제공된다:
여기서:
Bx는 헤테로환 염기 모이어티이고;
Ta 및 Tb 각각은, 독립적으로 H, 하이드록실 보호기, 공액체 그룹, 반응성 인 그룹, 인 모이어티, 또는 지지 매질에 대한 공유 부착(covalent attachment)이고;
Rd는 C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고;
각각의 qa, qb, qc 및 qd는 독립적으로, H, 할로겐, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐, C1-C6 알콕실, 치환된 C1-C6 알콕실, 아실, 치환된 아실, C1-C6 아미노알킬 또는 치환된 C1-C6 아미노알킬이다;
특정 구현예에서, 하기 화학식 V을 갖는 이환식 뉴클레오사이드가 제공된다:
여기서:
Bx는 헤테로환 염기 모이어티이고;
Ta 및 Tb 각각은, 독립적으로 H, 하이드록실 보호기, 공액체 그룹, 반응성 인 그룹, 인 모이어티, 또는 지지 매질에 대한 공유 부착(covalent attachment)이고;
qa, qb, qe 및 qf 각각은, 독립적으로, 수소, 할로겐, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C1-C12 알콕실, 치환된 C1-C12 알콕실, OJj, SJj, SOJj, SO2Jj, NJjJk, N3, CN, C(=O)OJj, C(=O)NJjJk, C(=O)Jj, O-C(=O)-NJjJk, N(H)C(=NH)NJjJk, N(H)C(=O)-NJjJk 또는 N(H)C(=S)NJjJk이고;
또는 qe 및 qf는 함께 =C(qg)(qh)이고;
qg 및 qh 각각은, 독립적으로, H, 할로겐, C1-C12 알킬, 또는 치환된 C1-C12 알킬이다.
메틸렌옥시 (4'-CH2-O-2') BNA 모노머 아데닌, 시토신, 구아닌, 5-메틸-시토신, 티민, 및 우라실의 합성 및 제조는, 그것의 올리고머화, 및 핵산 인식 특성과 함께 기재되었다 (참고, 예를 들면, Koshkin et al., Tetrahedron, 1998, 54, 3607-3630). BNA 및 이의 제조는 WO 98/39352 및 WO 99/14226에 또한 설명되어 있었다.
메틸렌옥시 (4'-CH2-O-2') BNA, 및 2'-티오-BNA의 유사체가 또한 제조되었다 (참고, 예를 들면, Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8, 2219-2222). 올리고데옥시리보뉴클레오타이드 듀플렉스를 핵산 폴리머라제의 기질로서 포함하는 락킹된(locked) 뉴클레오사이드 유사체의 제조가 또한 기재되었다 (참고, Wengel et al., WO 99/14226). 더욱이, 2'-아미노-BNA, 신규 형태적으로 제한된 고-친화도 올리고뉴클레오타이드 유사체의 합성은 당해기술에 기재되었다 (참고, 예를 들면, Singh et al., J. Org. Chem., 1998, 63, 10035-10039). 또한, 2'-아미노- 및 2'-메틸아미노-BNA'가 제조되었고 상보적 RNA 및 DNA 가닥을 갖는 그것의 듀플렉스의 열 안정성은 이전에 보고되었다.
특정 구현예에서, 하기 화학식 VI을 갖는 이환식 뉴클레오사이드가 제공된다:
여기서:
Bx는 헤테로환 염기 모이어티이고;
Ta 및 Tb 각각은, 독립적으로 H, 하이드록실 보호기, 공액체 그룹, 반응성 인 그룹, 인 모이어티, 또는 지지 매질에 대한 공유 부착(covalent attachment)이고;
qi, qj, qk 및 ql 각각은, 독립적으로, 수소, 할로겐, C1-C12 알킬, 치환된 C1-C12 알킬, C2-C12 알케닐, 치환된 C2-C12 알케닐, C2-C12 알키닐, 치환된 C2-C12 알키닐, C1-C12 알콕실, 치환된 C1-C12 알콕실, OJj, SJj, SOJj, SO2Jj, NJjJk, N3, CN, C(=O)OJj, C(=O)NJjJk, C(=O)Jj, O-C(=O)-NJjJk, N(H)C(=NH)NJjJk, N(H)C(=O)-NJjJk 또는 N(H)C(=S)NJjJk이고; 그리고
qi 및 qj 또는 ql 및 qk는 함께 =C(qg)(qh)이고, 여기서 qg 및 qh은 각각 독립적으로 H, 할로겐, C1-C12 알킬 또는 치환된 C1-C12 알킬이다.
4'-(CH2)3-2' 가교를 갖는 하나의 탄소환 이환식 뉴클레오사이드 및 알케닐 유사체 가교 4'-CH=CH-CH2-2'가 기재되었다 (참고, 예를 들면, Freier et al., Nucleic Acids Research, 1997, 25(22), 4429-4443 및 Albaek et al., J. Org. Chem., 2006, 71, 7731-7740). 탄소환 이환식 뉴클레오사이드의 합성 및 제조는 그것의 올리고머화 및 생화학적 연구와 함께 또한 기재되었다 (참고, 예를 들면, Srivastava et al., J. Am. Chem. Soc., 2007, 129(26), 8362-8379).
본원에서 사용된 바와 같이, "4'-2' 이환식 뉴클레오사이드" 또는 "4' 내지 2' 이환식 뉴클레오사이드"는 당 환의 2' 탄소 원자 및 4' 탄소 원자를 연결하는, 푸라노스 환의 두개의 탄소를 연결하는 가교를 포함하는 이환식 뉴클레오사이드를 의미한다.
본원에서 사용된 바와 같이, "일환식 뉴클레오사이드"는 이환식 당 모이어티가 아닌 변형된 당 모이어티를 포함하는 뉴클레오사이드를 의미한다. 특정 구현예에서, 뉴클레오사이드의 당 모이어티, 또는 당 모이어티 유사체는 임의의 위치에서 변형 또는 치환될 수 있다.
본원에서 사용된 바와 같이, "2'-변형된 당"는 2' 위치에서 변형된 푸라노실 당을 의미한다. 특정 구현예에서, 그와 같은 변형은 하기로부터 선택된 치환체를 포함한다: 치환된 및 비치환된 알콕시, 치환된 및 비치환된 티오알킬, 치환된 및 비치환된 아미노 알킬, 치환된 및 비치환된 알킬, 치환된 및 비치환된 알릴, 및 치환된 및 비치환된 알키닐을 비제한적으로 포함하는 할라이드. 특정 구현예에서, 2' 변형은 하기를 비제한적으로 포함하는 치환체로부터 선택된다: O[(CH2)nO]mCH3, O(CH2)nNH2, O(CH2)nCH3, O(CH2)nF, O(CH2)nONH2, OCH2C(=O)N(H)CH3, 및 O(CH2)nON[(CH2)nCH3]2 (여기서 n 및 m은 1 내지 약 10이다). 다른 2' 치환체 그룹은 또한 하기로부터 선택될 수 있다: C1-C12 알킬, 치환된 알킬, 알케닐, 알키닐, 알카릴, 아랄킬, O-알카릴 또는 O-아랄킬, SH, SCH3, OCN, Cl, Br, CN, F, CF3, OCF3, SOCH3, SO2CH3, ONO2, NO2, N3, NH2, 헤테로사이클로알킬, 헤테로사이클로알카릴, 아미노알킬아미노, 폴리-알킬아미노. 치환된 실릴, RNA 절단 그룹, 리포터 그룹, 삽입제, 약력학적 특성을 개선하는 그룹, 및 안티센스 화합물의 약동학적 특성을 개선하는 그룹, 및 유사한 특성을 갖는 다른 치환체. 특정 구현예에서, 변형된 뉴클레오사이드는 2'-MOE 측쇄를 포함한다 (참고, 예를 들면, Baker et al., J. Biol. Chem., 1997, 272, 11944-12000). 그와 같은 2'-MOE 치환은 비변형된 뉴클레오사이드 및 다른 변형된 뉴클레오사이드, 예컨대 2'- O-메틸, O-프로필, 및 O-아미노프로필과 비교하여 개선된 결합 친화도를 갖는 것으로 기재되었다. 2'-MOE 치환체를 갖는 올리고뉴클레오타이드는 또한 체내 사용을 위해 유망한 특징을 갖는 유전자 발현의 안티센스 억제제인 것으로 보여졌다 (참고, 예를 들면, Martin, Helv. Chim. Acta, 1995, 78, 486-504; Altmann et al., Chimia, 1996, 50, 168-176; Altmann et al., Biochem. Soc. Trans., 1996, 24, 630-637; 및 Altmann et al., Nucleosides Nucleotides, 1997, 16, 917-926).
본원에서 사용된 바와 같이, "변형된 테트라하이드로피란 뉴클레오사이드" 또는 "변형된 THP 뉴클레오사이드"는 정상 뉴클레오사이드 (당 대용물)에서 펜토푸라노실 잔기를 대체하기 위해 치환된 6-원 테트라하이드로피란 "당"을 갖는 뉴클레오사이드를 의미한다. 변형된 THP 뉴클레오사이드는, 비제한적으로, 헥시톨 핵산 (HNA), 아니톨 핵산 (ANA), 만니톨 핵산 (MNA) (참고 Leumann, Bioorg. Med. Chem., 2002, 10, 841-854), 플루오로 HNA (F-HNA)로서 본 분야에서 지칭되는 것들, 또는 하기 화학식 VII을 갖는 화합물을 포함한다:
여기서 독립적으로 화학식 VII의 각각의 상기 적어도 하나의 테트라하이드로피란 뉴클레오사이드 유사체에 대해:
Bx는 헤테로환 염기 모이어티이고;
Ta 및 Tb 각각은, 독립적으로, 테트라하이드로피란 뉴클레오사이드 유사체를 안티센스 화합물에 연결시키는 뉴클레오사이드간 연결기이거나 Ta 및 Tb 중 하나는 테트라하이드로피란 뉴클레오사이드 유사체를 안티센스 화합물에 연결시키는 뉴클레오사이드간 연결기이고, Ta 및 Tb 중 다른 것은 H, 하이드록실 보호기, 연결된 공액체 그룹, 또는 5' 또는 3'-말단기이고;
q1, q2, q3, q4, q5, q6 및 q7은 각각 독립적으로, H, C1-C6 알킬, 치환된 C1-C6 알킬, C2-C6 알케닐, 치환된 C2-C6 알케닐, C2-C6 알키닐 또는 치환된 C2-C6 알키닐이고; 그리고 각각의 R1 및 R2는 수소, 히드록실, 할로겐, 치환된 또는 비치환된 알콕시, NJ1J2, SJ1, N3, OC(=X)J1, OC(=X)NJ1J2, NJ3C(=X)NJ1J2 및 CN으로부터 선택되고, 여기서 X는 O, S 또는 NJ1이고, 그리고 각각의 J1, J2 및 J3 는 독립적으로, H 또는 C1-C6 알킬이다.
특정 구현예에서, 화학식 VII의 변형된 THP 뉴클레오사이드가 제공되며, 여기서 q1, q2, q3, q4, q5, q6 및 q7는 각각 H이다. 특정 구현예에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 H 이외의 것이다. 특정 구현예에서, q1, q2, q3, q4, q5, q6 및 q7 중 적어도 하나는 메틸이다. 특정 구현예에서, 식 VII의 THP 뉴클레오사이드가 제공되고, 여기서 R1 및 R2 중 하나는 플루오로이다. 특정 구현예에서, R1은 플루오로이고 R2는 H이고; R1은 메톡시이고 R2는 H이고, 그리고 R1은 H이고, R2는 메톡시에톡시이다.
본원에서 사용된 바와 같이, "2'-변형된" 또는 "2'-치환된"은 H 또는 OH 이외의 2' 위치에서 치환체를 포함하는 당을 포함하는 뉴클레오사이드를 의미한다. 2'-변형된 뉴클레오사이드는, 비제한적으로, 이환식 뉴클레오사이드 (여기서 당 환의 2 개의 탄소 원자를 연결하는 가교는 당 환의 2' 탄소 및 다른 탄소를 연결한다); 및 비-가교 2' 치환체, 예컨대 알릴, 아미노, 아지도, 티오, O-알릴, O-C1-C10 alkyl, -OCF3, O-(CH2)2-O-CH3, 2'-O(CH2)2SCH3, O-(CH2)2-O-N(Rm)(Rn), 또는 O-CH2-C(=O)-N(Rm)(Rn)를 갖는 뉴클레오사이드 (여기서 각각의 Rm 및 Rn는, 독립적으로, H 또는 치환된 또는 비치환된 C1-C10 알킬이다)를 포함한다. 2'-변형된 뉴클레오사이드는 예를 들면, 당의 다른 위치에서 및/또는 핵염기에서 다른 변형을 추가로 포함할 수 있다.
본원에서 사용된 바와 같이, "2'-F"는 2' 위치에서 플루오로 기를 포함하는 당을 지칭한다.
본원에서 사용된 바와 같이, "2'-OMe" 또는 "2'-OCH3" 또는 "2'-O-메틸" 각각은 당 환의 2' 위치에서-OCH3 기를 포함하는 당을 포함하는 뉴클레오사이드를 지칭한다.
본원에서 사용된 바와 같이, "MOE" 또는 "2'-MOE" 또는 "2'-OCH2CH2OCH3" 또는 "2'-O-메톡시에틸" 각각은 당 환의 2' 위치에서 -OCH2CH2OCH3 기를 포함하는 당을 포함하는 뉴클레오사이드를 지칭한다.
본원에서 사용된 바와 같이, "올리고뉴클레오타이드"는 복수의 연결된 뉴클레오사이드를 포함하는 화합물을 지칭한다. 특정 구현예에서, 복수의 뉴클레오사이드 중 하나 이상이 변형된다. 특정 구현예에서, 올리고뉴클레오타이드는 하나 이상의 리보뉴클레오사이드(RNA) 및/또는 데옥시리보뉴클레오사이드(DNA)를 포함한다.
많은 다른 이환식 및 삼환식 당 대용물 고리계는 또한 당해기술에 공지되어 있고 안티센스 화합물에 통합시키기 위한 뉴클레오사이드를 변형하기 위해 사용될 수 있다 (참고, 예를 들면, 검토 논문: Leumann, Bioorg. Med. Chem., 2002, 10, 841-854).
그와 같은 고리계는 활성을 향상시키기 위해 다양한 부가적 치환을 경험할 수 있다.
변형된 당류의 제조 방법은 당해분야의 숙련가에게 잘 공지되어 있다.
변형된 당 모이어티를 갖는 뉴클레오타이드에서, 핵염기 모이어티 (천연, 변형된, 또는 이들의 조합)은 적절한 핵산 표적과의 혼성화를 위해 유지된다.
특정 구현예에서, 안티센스 화합물은 변형된 당 모이어티를 갖는 하나 이상의 뉴클레오사이드를 포함한다. 특정 구현예에서, 변형된 당 모이어티는 2'-MOE이다. 특정 구현예에서, 2'-MOE 변형된 뉴클레오사이드는 갭머 모티프에서 배열된다. 특정 구현예에서, 상기 변형된 당 모이어티는 (4'-CH(CH3)-O-2')) 가교기를 갖는 이환식 뉴클레오사이드이다. 특정 구현예에서, 상기 (4'-CH(CH3)-O-2') 변형된 뉴클레오사이드는 갭머 모티프의 윙에 걸쳐 배열된다.
약제학적 조성물을 제형화하기 위한 조성물 및 방법
안티센스 올리고뉴클레오타이드는 약제학적 조성물 또는 제형의 제조를 위한 약제학적으로 허용가능한 활성 또는 불활성 물질과 혼합될 수 있다. 조성물 및 약제학적 조성물의 제형 방법은 수많은 기준에 의존하고, 이 기준은, 비제한적으로, 투여 경로, 질환 정도, 또는 투여될 복용량을 포함한다.
타우 핵산에 표적화된 안티센스 화합물은 안티센스 화합물을 적당한 약제학적으로 허용가능한 희석제 또는 담체와 조합함으로써 약제학적 조성물에서 이용될 수 있다. 약제학적으로 허용가능한 희석제는 포스페이트-완충 식염수 (PBS)를 포함한다. PBS는 비경구로 전달될 조성물에서 사용하기에 적당한 희석제이다. 따라서, 일 구현예에서, 타우 핵산에 표적화된 안티센스 화합물 및 약제학적으로 허용가능한 희석제를 포함하는 약제학적 조성물이 본원에 기재된 방법에서 이용된다. 특정 구현예에서, 약제학적으로 허용가능한 희석제는 PBS이다. 특정 구현예에서, 안티센스 화합물은 안티센스 올리고뉴클레오타이드이다.
안티센스 화합물을 포함하는 약제학적 조성물은 임의의 약제학적으로 허용가능한 염, 에스테르, 또는 그와 같은 에스테르의 염, 또는 인간을 포함하는 동물에게 투여시, (직접적으로 또는 간접적으로) 생물학적 활성 대사물 또는 그의 잔류물을 제공할 수 있는 임의의 다른 올리고뉴클레오타이드을 포함한다. 따라서, 예를 들면, 본 개시내용은 또한 안티센스 화합물의 약제학적으로 허용가능한 염, 프로드러그, 그와 같은 프로드러그의 약제학적으로 허용가능한 염, 및 다른 생체동등물에 관한 것이다. 적당한 약제학적으로 허용가능한 염은, 비제한적으로, 나트륨 및 칼륨 염을 포함한다.
프로드러그는 활성 안티센스 화합물을 형성하도록 내인성 뉴클레아제에 의해 절단된 안티센스 화합물의 하나 또는 둘 모두의 말단에서 부가적 뉴클레오사이드의 통합을 포함한다.
공액된 안티센스 화합물
안티센스 화합물은 수득한 안티센스 올리고뉴클레오타이드의 활성, 세포 분포 또는 세포 흡수를 향상시키는 하나 이상의 모이어티 또는 공액체에 공유연결될 수 있다. 전형적인 공액체 그룹은 콜레스테롤 모이어티 및 지질 모이어티를 포함한다. 부가적 공액체 그룹은 탄수화물, 인지질, 비오틴, 펜아진, 엽산, 펜안트리딘, 안트라퀴논, 아크리딘, 플루오레신, 로다민, 쿠마린, 및 염료를 포함한다.
안티센스 화합물은 또한 뉴클레아제 안정성과 같은 특성을 개선하기 위해 안티센스 화합물의 하나 또는 둘 모두 말단에 일반적으로 부착된 하나 이상의 안정화 그룹을 갖도록 또한 변형될 수 있다. 안정화 그룹에 캡 구조가 포함된다. 이들 말단 변형은 엑소뉴클레아제 분해로부터 말단 핵산을 갖는 안티센스 화합물을 보호하고, 세포 내에서 전달 및/또는 국지화를 도울 수 있다. 캡은 5'-말단 (5'-캡), 또는 3'-말단 (3'-캡)에서 존재할 수 있고, 또는 말단 둘에서 존재할 수 있다. 캡 구조는 당해기술에서 잘 공지되어 있고, 예를 들면, 역전된 데옥시 무염기성 캡을 포함한다. 뉴클레아제 안정성을 부여하기 위해 안티센스 화합물의 하나 또는 둘 모두의 말단을 캡핑하기 위해 사용될 수 있는 추가의 3' 및 5'-안정화 그룹은 WO 03/004602 (2003년 1월 16일 공개)에서 개시된 것을 포함한다.
세포 배양물 및 안티센스 화합물 치료
타우 핵산의 수준, 활성 또는 발현에 대한 안티센스 화합물의 효과는 다양한 세포 유형에서 시험관내에서 시험될 수 있다. 그와 같은 분석을 위해 사용된 세포 유형은 상업적 판매인 (예를 들면 American Type Culture Collection, Manassus, VA; Zen-Bio, Inc., Research Triangle Park, NC; Clonetics Corporation, Walkersville, MD)으로부터 이용가능하고 상업적으로 이용가능한 시약을 사용하여 판매인의 지침에 따라 배양된다 (예를 들면 Invitrogen Life Technologies, Carlsbad, CA). 예시적인 세포 유형은, 비제한적으로, HepG2 세포 Hep3B 세포, 및 일차 간세포를 포함한다.
안티센스 올리고뉴클레오타이드의 시험관내 시험
다른 안티센스 화합물에 의한 치료를 위해 적절하게 변형될 수 있는 안티센스 올리고뉴클레오타이드에 의한 세포의 치료 방법이 본원에 기재되어 있다.
세포는, 세포가 배양물에서 대략 60-80% 밀집도에 도달할 때 안티센스 올리고뉴클레오타이드로 처리될 수 있다.
안티센스 올리고뉴클레오타이드를 배양 세포에 도입하기 위해 통상적으로 사용된 하나의 시약은 양이온성 지질 형질감염 시약 LIPOFECTIN (Invitrogen, Carlsbad, CA)을 포함한다. 안티센스 올리고뉴클레오타이드는 안티센스 올리고뉴클레오타이드의 원하는 최종 농도 및 2 내지 12 ug/mL / 100 nM 안티센스 올리고뉴클레오타이드 범위인 LIPOFECTIN 농도를 달성하기 위해 OPTI-MEM 1 (Invitrogen, Carlsbad, CA) 중에서 LIPOFECTIN와 혼합된다.
안티센스 올리고뉴클레오타이드를 배양 세포에 도입하기 위해 사용된 또 하나의 시약은 LIPOFECTAMINE (Invitrogen, Carlsbad, CA)을 포함한다. 안티센스 올리고뉴클레오타이드는 안티센스 올리고뉴클레오타이드의 원하는 농도 및 2 내지 12 ug/mL / 100 nM 안티센스 올리고뉴클레오타이드 범위인 LIPOFECTAMINE 농도를 달성하기 위해 OPTI-MEM 1 감소된 혈청 배지 (Invitrogen, Carlsbad, CA)에서 LIPOFECTAMINE와 혼합된다.
안티센스 올리고뉴클레오타이드를 배양 세포에 도입하기 위해 사용된 또 하나의 기술은 전기천공을 포함한다.
세포는 통상적인 방법에 의해 안티센스 올리고뉴클레오타이드로 처리된다. 세포는 전형적으로 안티센스 올리고뉴클레오타이드 처리 16-24 시간 후에 수확되고, 그 시간에 표적 핵산의 RNA 또는 단백질 수준은 당해분야에서 공지되고 본원에 기재된 방법으로 측정된다. 일반적으로, 처리가 다중 복제물에서 수행될 때, 데이타는 복제물 처리의 평균치로서 제공된다.
사용된 안티센스 올리고뉴클레오타이드의 농도는 세포주 내지 세포주 사이에서 변화한다. 특정한 세포주에 대한 최적의 안티센스 올리고뉴클레오타이드 농도를 측정하는 방법은 당해기술에 공지되어 있다. 안티센스 올리고뉴클레오타이드는 LIPOFECTAMINE으로 형질감염될 때 1 nM 내지 300 nM 범위의 농도에서 전형적으로 사용된다. 안티센스 올리고뉴클레오타이드는 전기천공을 사용하여 형질감염될 때 625 내지 20,000 nM 범위의 고농도에서 사용된다.
RNA 단리
RNA 분석은 총 세포 RNA 또는 폴리(A)+ mRNA에 대해 수행될 수 있다. RNA 단리의 방법은 당해기술에 공지되어 있다. RNA는 제조자의 추천된 프로토콜에 따라 당해기술에서 공지된 방법, 예를 들면, TRIZOL 시약 (Invitrogen, Carlsbad, CA)을 사용하여 제조된다.
표전 수준 또는 발현의 억제 분석
타우 핵산의 수준 또는 발현의 억제는 당해기술에서 공지된 다양한 방식으로 검정될 수 있다. 예를 들면, 표적 핵산 수준은, 예를 들면, 노던 블랏 분석, 경쟁적 폴리머라제 연쇄 반응 (PCR), 또는 정량적 실시간 PCR에 의해 정량화될 수 있다. RNA 분석은 총 세포 RNA 또는 폴리(A)+ mRNA에 대해 수행될 수 있다. RNA 단리의 방법은 당해기술에 공지되어 있다. 노던 블랏 분석은 당해기술에서 또한 통상적이다. 정량적 실시간 PCR은 상업적으로 이용가능한 ABI PRISM 7600, 7700, 또는 7900 서열 검출 시스템 (PE-Applied Biosystems, Foster City, CA로부터 이용가능)을 사용하여 편리하게 달성될 수 있고 제조자의 지침에 따라 사용된다.
표적 RNA 수준의 정량적 실시간 PCR 분석
표적 RNA 수준의 정량화는 제조자의 지침에 따라 ABI PRISM 7600, 7700, 또는 7900 서열 검출 시스템 (PE-Applied Biosystems, Foster City, CA)을 사용하여 정량적 실시간 PCR에 의해 달성될 수 있다. 정량적 실시간 PCR의 방법은 당해기술에 공지되어 있다.
실시간 PCR 전에, 단리된 RNA에 대해 역전사효소 (RT) 반응이 수행되고, 이 반응은 상보적 DNA (cDNA)를 생산하고 이후 실시간 PCR 증폭에 대한 기질로서 사용된다. RT 및 실시간 PCR 반응은 동일 샘플 웰에서 순차적으로 수행된다. RT 및 실시간 PCR 시약은 Invitrogen (Carlsbad, CA)로부터 수득될 수 있다. RT, 실시간-PCR 반응은 당해분야의 숙련가에게 공지된 방법에 의해 수행된다.
실시간 PCR에 의해 수득된 유전자 (또는 RNA)는, 발현이 일정한 유전자, 예컨대 사이클로필린 A의 발현 수준을 사용하거나, RIBOGREEN (Invitrogen, Inc. Carlsbad, CA)을 사용하여 총 RNA를 정량화하여 정규화된다. 사이클로필린 A 발현은 실시간 PCR에 의해, 표적과 동시에, 다중화, 또는 별도로 시행하여 정량화된다. 총 RNA는 리보그린 RNA 정량화 시약 (Invetrogen, Inc. Eugene, OR)을 사용하여 정량화된다. RIBOGREEN에 의한 RNA 정량화의 방법은 하기에서 교시된다: Jones, L.J., 등, (Analytical Biochemistry, 1998, 265, 368-374). CYTOFLUOR 4000 기기 (PE Applied Biosystems)는 RIBOGREEN 형광을 측정하기위해 사용된다.
프로브 및 프라이머는 타우 핵산에 대한 혼성화를 위해 설계된다. 실시간 PCR 프로브 및 프라이머를 설계하는 방법은 당해기술에 공지되어 있고 소프트웨어 예컨대 PRIMER EXPRESS 소프트웨어 (Applied Biosystems, Foster City, CA)의 사용을 포함할 수 있다
단백질 수준 분석
타우 핵산의 안티센스 억제는 타우 단백질 수준을 측정하여 평가될 수 있다. 타우의 단백질 수준은 당해기술에 공지된 다양한 방식, 예컨대 면역침전, 웨스턴 블랏 분석 (면역블로팅), 효소-연결 면역흡착 검정 (ELISA), 정량적 단백질 검정, 단백질 활성 검정 (예를 들면, 카스파제 활성 검정), 면역조직화학, 면역세포화학 또는 형광-활성화된 세포 분류 (FACS)으로 평가 또는 정량화될 수 있다. 표적에 대해 지향된 항체는 다양한 공급원, 예컨대 항체의 MSRS 카탈로그 (Aerie Corporation, Birmingham, MI)으로부터 확인 및 수득될 수 있고, 또는 당해기술에 잘 공지된 종래의 모노클로날 또는 폴리클로날 항체 생성 방법을 통해 제조될 수 있다.
안티센스 화합물의 체내 시험
안티센스 화합물, 예를 들면, 안티센스 올리고뉴클레오타이드는, 타우의 발현을 억제하고 표현형 변화를 생성하기 위해 그것의 능력을 평가하기 위해 동물에서 시험된다. 특정 구현예에서, 인식은 신규 목적 인식 및 네스트레트(nestlet) 구축 활성에 의하여 측정된다. 특정 구현예에서, 운동 기능은 동물에서의 보행 개시 분석, 로타로드(rotarod), 악력, 폴 크라이밍(pole climb), 오픈 필드 수행, 발란스 빔, 뒷발 발자국 시험에 의하여 측정될 수 있다. 특정 구현예에서, 안티센스 화합물, 예를 들면, 안티센스 올리고뉴클레오타이드는, 과인산화된 타우 및 신경섬유 매듭을 감소시키는 이들의 능력을 평가하기 위하여 동물에서 시험된다. 특정 구현예에서, 안티센스 화합물, 예를 들면, 안티센스 올리고뉴클레오타이드는, 펜틸렌테트라졸 (PTZ) 유도 발작(seizure) 모델에서의 발작의 중증도를 예방하고/하거나 감소시키는 이들의 능력을 평가하기 위하여 동물에서 시험된다.
시험은 정상동물, 또는 실험 질환 모델에서 수행될 수 있다. 동물에의 투여에 대해, 안티센스 올리고뉴클레오타이드는 약제학적으로 허용가능한 희석제, 예컨대 포스페이트-완충 식염수에서 제형화된다. 투여는, 예를 들어 복강내, 정맥내 및 피하와 같은 비경구 투여 경로를 포함한다. 안티센스 올리고뉴클레오타이드 투여 및 투여 빈도의 산출은 당업자의 능력 내에 있으며, 투여 경로 및 동물 체중과 같은 인자에 따라 달라진다. 안티센스 올리고뉴클레오타이드에 의한 치료 기간 후, RNA는 CNS 조직 또는 CSF로부터 단리되고 타우 핵산 발현에서의 변화가 측정된다.
특정 징후
특정 구현예에서, 개체를 치료하는 방법이 본원에서 제공되고, 이 방법은 본원에 기재된 바와 같은 하나 이상의 약제학적 조성물을 투여하는 단계를 포함한다. 특정 구현예에서, 개체는 신경변성 질환을 갖는다. 특정 구현예에서, 상기 개체는 비제한적으로 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 및 드라벳 증후군을 포함하는 신경변성 질환이 발병할 위험에 처해있다. 특정 구현예에서, 개체는 타우 관련된 질환을 갖는 것으로 동정된다. 특정 구현예에서, 개체에서 타우 발현은 방지적으로 감소시키는 방법이 제공된다. 특정 구현예는 타우 핵산에 표적화된 안티센스 화합물의 치료학적 유효량을 개체에 투여함으로써 이를 필요로하는 개체를 치료하는 것을 포함한다.
일 구현예에서, 타우 핵산에 표적화된 안티센스 화합물의 치료학적 유효량의 투여는 개체에서 타우 수준을 모니터링하여 안티센스 화합물 투여에 대한 개체의 반응을 측정하는 것을 수반한다. 안티센스 화합물 투여에 대한 개체의 반응은 치료적 처치의 양 및 기간을 결정하는 의료진에 의하여 사용될 수 있다.
특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물의 투여는 적어도 15, 20, 25, 30, 35, 40, 45, 50, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 또는 100%, 또는 상기 값 중 임의의 2개에 의하여 정의된 범위 내로 타우 발현의 감소를 초래한다. 특정 구현예에서, 타우 핵산에 표적화된 안티센스 화합물의 투여는 동물에서 개선된 운동 기능을 초래한다. 특정 구현예에서, 타우 안티센스 화합물의 투여는 적어도 15, 20, 25, 30, 35, 40, 45, 50, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 또는 100%, 또는 상기 값 중 임의의 2개에 의하여 정의된 범위 내로 운동 기능을 개선한다.
특정 구현예에서, 타우에 표적화된 안티센스 화합물을 포함하는 약제학적 조성물은 타우병증, 알츠하이머 질환, 전두측두엽 치매 (FTD), FTDP-17, 진행성 핵상안근 마비 (PSP), 만성 외상성 뇌증 (CTE), 뇌피질 기저 신경절 퇴행증 (CBD), 간질, 및 드라벳 증후군을 포함하는 신경변성 질환을 앓고 있거나 이에 취약한 환자를 치료하는 약제의 제조에 사용된다.
특정 빈발 영역
1. 서열 번호: 1의 핵염기 135783-135980
특정 구현예에서, 안티센스 올리고뉴클레오타이드는 서열 번호: 1의 표적 핵염기 135783-135980 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 유전자 은행 수탁 번호 NT_010783.15)를 표적화하기 위하여 설계된다. 특정 구현예에서, 핵염기 135783-135980은 빈발 영역이다. 특정 구현예에서, 핵염기 135783-135980은 안티센스 올리고뉴클레오타이드에 의하여 표적화된다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 그 길이가 18, 19, 또는 20개의 핵염기이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머, 5-9-5 MOE 갭머, 5-7-6 MOE 갭머 및 5-8-5 MOE 갭머이다. 특정 구현예에서, 안티센스 화합물의 뉴클레오사이드는 포스포로티오에이트 뉴클레오사이드간 연결으로 연결된다. 특정 구현예에서, 안티센스 화합물의 각각의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드의 뉴클레오사이드는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결에 의하여 연결된다 (예컨대 안티센스 올리고뉴클레오타이드는 "혼합 뼈대"를 갖는다).
특정 구현예에서, 핵염기 135783-135980은 하기 ISIS 번호에 의하여 표적화된다: 424879, 424880, 548937, 613114-613120, 622096-622150, 623988-623996, 664511-664542, 및 664661-664819.
특정 구현예에서, 핵염기 135783-135980은 하기 서열 번호에 의하여 표적화된다: 56, 57, 248, 462-467, 1668-1698, 2025-2048, 2301-2309, 2331- 2443, 및 2478-2483.
특정 구현예에서, 핵염기 135783-135980를 표적화하는 안티센스 올리고뉴클레오타이드는 시험관내 및/또는 시험관내에서의 타우 mRNA 및 또는 단백질 수준의 적어도 12%, 적어도 13%, 적어도 14%, 적어도 15%, 적어도 16%, 적어도 17%, 적어도 18%, 적어도 19%, 20%, 적어도 21%, 적어도 22%, 적어도 23%, 적어도 24%, 적어도 25%, 적어도 26%, 적어도 27%, 적어도 28%, 적어도 29%, 적어도 30%, 적어도 31%, 적어도 32%, 적어도 33%, 적어도 34%, 적어도 35%, 적어도 36%, 적어도 37%, 적어도 38%, 적어도 39%, 적어도 40%, 적어도 41%, 적어도 42%, 적어도 43%, 적어도 44%, 적어도 45%, 적어도 46%, 적어도 47%, 적어도 48%, 적어도 49%, 적어도 50%, 적어도 51%, 적어도 52%, 적어도 53%, 적어도 54%, 적어도 55%, 적어도 56%, 적어도 57%, 적어도 58%, 적어도 59%, 적어도 60%, 적어도 61%, 적어도 62%, 적어도 63%, 적어도 64%, 적어도 65%, 적어도 66%, 적어도 67%, 적어도 68%, 적어도 69%, 적어도 70%, 적어도 71%, 적어도 72%, 적어도 73%, 적어도 74%, 적어도 75%, 적어도 76%, 적어도 77%, 적어도 78%, 적어도 79%, 적어도 80%, 적어도 81%, 적어도 82%, 적어도 83%, 적어도 84%, 적어도 85%, 적어도 86%, 적어도 87%, 적어도 88%, 적어도 89%, 적어도 90%, 적어도 91%, 적어도 92%, 또는 적어도 93%의 감소를 달성한다.
2. 서열 번호: 1의 핵염기 135853-135872
특정 구현예에서, 안티센스 올리고뉴클레오타이드는 서열 번호: 1의 표적 핵염기 135853-135872 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 유전자 은행 수탁 번호 NT_010783.15)를 표적화하기 위하여 설계된다. 특정 구현예에서, 핵염기 135853-135872는 빈발 영역이다. 특정 구현예에서, 핵염기 135853-135872은 안티센스 올리고뉴클레오타이드에 의하여 표적화된다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 그 길이가 18, 19, 또는 20개의 핵염기이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머, 5-9-5 MOE 갭머, 5-7-6 MOE 갭머 또는 5-8-5 MOE 갭머이다. 특정 구현예에서, 안티센스 화합물의 뉴클레오사이드는 포스포로티오에이트 뉴클레오사이드간 연결으로 연결된다. 특정 구현예에서, 안티센스 화합물의 각각의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드의 뉴클레오사이드는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결에 의하여 연결된다 (예컨대 안티센스 올리고뉴클레오타이드는 "혼합 뼈대"를 갖는다).
특정 구현예에서, 핵염기 135853-135872은 하기 ISIS 번호에 의하여 표적화된다: 424879, 424880, 613117, 613118, 622114-622125, 623993-623996, 664522-664542, 664676-664713, 664729-664766, 및 664783-664819.
특정 구현예에서, 핵염기 135853-135872은 하기 서열 번호에 의하여 표적화된다: 56, 57, 248, 464-465, 1668-1673, 2039-2048, 2306-2309, 2345-2443, 및 2478-2483.
특정 구현예에서, 핵염기 135853-135872를 표적화하는 안티센스 올리고뉴클레오타이드는 시험관내 및/또는 시험관내에서의 타우 mRNA 및 또는 단백질 수준의 적어도 36%, 적어도 37%, 적어도 38%, 적어도 39%, 적어도 40%, 적어도 41%, 적어도 42%, 적어도 43%, 적어도 44%, 적어도 45%, 적어도 46%, 적어도 47%, 적어도 48%, 적어도 49%, 적어도 50%, 적어도 51%, 적어도 52%, 적어도 53%, 적어도 54%, 적어도 55%, 적어도 56%, 적어도 57%, 적어도 58%, 적어도 59%, 적어도 60%, 적어도 61%, 적어도 62%, 적어도 63%, 적어도 64%, 적어도 65%, 적어도 66%, 적어도 67%, 적어도 68%, 적어도 69%, 적어도 70%, 적어도 71%, 적어도 72%, 적어도 73%, 적어도 74%, 적어도 75%, 적어도 76%, 적어도 77%, 적어도 78%, 적어도 79%, 적어도 80%, 적어도 81%, 적어도 82%, 적어도 83%, 적어도 84%, 적어도 85%, 적어도 86%, 또는 적어도 87%의 감소를 달성한다.
3. 서열 번호: 1의 핵염기 135783-135929
특정 구현예에서, 안티센스 올리고뉴클레오타이드는 서열 번호: 1의 표적 핵염기 135783-135929 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 유전자 은행 수탁 번호 NT_010783.15)를 표적화하기 위하여 설계된다. 특정 구현예에서, 핵염기 135783-135929는 빈발 영역이다. 특정 구현예에서, 핵염기 135783-135929 안티센스 올리고뉴클레오타이드에 의하여 표적화된다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 그 길이가 18, 19, 또는 20개의 핵염기이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머, 5-9-5 MOE 갭머, 5-7-6 MOE 갭머 또는 5-8-5 MOE 갭머이다. 특정 구현예에서, 안티센스 화합물의 뉴클레오사이드는 포스포로티오에이트 뉴클레오사이드간 연결으로 연결된다. 특정 구현예에서, 안티센스 화합물의 각각의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드의 뉴클레오사이드는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결에 의하여 연결된다 (예컨대 안티센스 올리고뉴클레오타이드는 "혼합 뼈대"를 갖는다).
특정 구현예에서, 핵염기 135783-135929는 하기 ISIS 번호에 의하여 표적화된다: 424879, 424880, 548937, 613114-613119, 622096-622138, 623988-623996, 664511-664542, 및 664661-664819.
특정 구현예에서, 핵염기 135783-135929는 하기 서열 번호에 의하여 표적화된다: 56, 57, 248, 462-466, 1668-1686, 2025-2048, 2301-2309, 2331-2443, 및 2478-2483.
특정 구현예에서, 핵염기 135783-135929를 표적화하는 안티센스 올리고뉴클레오타이드는 시험관내 및/또는 시험관내에서의 타우 mRNA 및 또는 단백질 수준의 적어도 12%, 적어도 13%, 적어도 14%, 적어도 15%, 적어도 16%, 적어도 17%, 적어도 18%, 적어도 19%, 20%, 적어도 21%, 적어도 22%, 적어도 23%, 적어도 24%, 적어도 25%, 적어도 26%, 적어도 27%, 적어도 28%, 적어도 29%, 적어도 30%, 적어도 31%, 적어도 32%, 적어도 33%, 적어도 34%, 적어도 35%, 적어도 36%, 적어도 37%, 적어도 38%, 적어도 39%, 적어도 40%, 적어도 41%, 적어도 42%, 적어도 43%, 적어도 44%, 적어도 45%, 적어도 46%, 적어도 47%, 적어도 48%, 적어도 49%, 적어도 50%, 적어도 51%, 적어도 52%, 적어도 53%, 적어도 54%, 적어도 55%, 적어도 56%, 적어도 57%, 적어도 58%, 적어도 59%, 적어도 60%, 적어도 61%, 적어도 62%, 적어도 63%, 적어도 64%, 적어도 65%, 적어도 66%, 적어도 67%, 적어도 68%, 적어도 69%, 적어도 70%, 적어도 71%, 적어도 72%, 적어도 73%, 적어도 74%, 적어도 75%, 적어도 76%, 적어도 77%, 적어도 78%, 적어도 79%, 적어도 80%, 적어도 81%, 적어도 82%, 적어도 83%, 적어도 84%, 적어도 85%, 적어도 86%, 적어도 87%, 적어도 88%, 적어도 89%, 적어도 90%, 적어도 91%, 적어도 92%, 또는 적어도 93%의 감소를 달성한다.
4. 서열 번호: 1의 핵염기 135783-135914
특정 구현예에서, 안티센스 올리고뉴클레오타이드는 서열 번호: 1의 표적 핵염기 135783-135914 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 유전자 은행 수탁 번호 NT_010783.15)를 표적화하기 위하여 설계된다. 특정 구현예에서, 핵염기 135783-135914는 빈발 영역이다. 특정 구현예에서, 핵염기 135783-135914는 안티센스 올리고뉴클레오타이드에 의하여 표적화된다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 그 길이가 18, 19, 또는 20개의 핵염기이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드는 갭머이다. 특정 구현예에서, 갭머는 5-10-5 MOE 갭머, 5-9-5 MOE 갭머, 5-7-6 MOE 갭머 또는 5-8-5 MOE 갭머이다. 특정 구현예에서, 안티센스 화합물의 뉴클레오사이드는 포스포로티오에이트 뉴클레오사이드간 연결으로 연결된다. 특정 구현예에서, 안티센스 화합물의 각각의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이다. 특정 구현예에서, 안티센스 올리고뉴클레오타이드의 뉴클레오사이드는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결에 의하여 연결된다 (예컨대 안티센스 올리고뉴클레오타이드는 "혼합 뼈대"를 갖는다).
특정 구현예에서, 핵염기 135783-135914은 하기 ISIS 번호에 의하여 표적화된다: 424879, 424880, 548937, 613114-613119, 622096-622133, 623988-623996, 664511-664542, 664661-664819.
특정 구현예에서, 핵염기 135783-135914는 하기 서열 번호에 의하여 표적화된다: 56, 57, 248, 462-466, 1668-1681, 2025-2048, 2301-2309, 2331-2443, 및 2478-2483.
특정 구현예에서, 핵염기 135783-135914은 하기 ISIS 번호에 의하여 표적화된다: 424879, 424880, 548937, 613114-613119, 622096- 622133, 및 623988- 623996.
특정 구현예에서, 핵염기 135783-135914는 하기 서열 번호에 의하여 표적화된다: 56, 57, 248, 462-466, 1668-1681, 2025-2048, 및 2301-2309.
특정 구현예에서, 핵염기 135783-135914를 표적화하는 안티센스 올리고뉴클레오타이드는 시험관내 및/또는 시험관내에서의 타우 mRNA 및 또는 단백질 수준의 적어도 12%, 적어도 13%, 적어도 14%, 적어도 15%, 적어도 16%, 적어도 17%, 적어도 18%, 적어도 19%, 20%, 적어도 21%, 적어도 22%, 적어도 23%, 적어도 24%, 적어도 25%, 적어도 26%, 적어도 27%, 적어도 28%, 적어도 29%, 적어도 30%, 적어도 31%, 적어도 32%, 적어도 33%, 적어도 34%, 적어도 35%, 적어도 36%, 적어도 37%, 적어도 38%, 적어도 39%, 적어도 40%, 적어도 41%, 적어도 42%, 적어도 43%, 적어도 44%, 적어도 45%, 적어도 46%, 적어도 47%, 적어도 48%, 적어도 49%, 적어도 50%, 적어도 51%, 적어도 52%, 적어도 53%, 적어도 54%, 적어도 55%, 적어도 56%, 적어도 57%, 적어도 58%, 적어도 59%, 적어도 60%, 적어도 61%, 적어도 62%, 적어도 63%, 적어도 64%, 적어도 65%, 적어도 66%, 적어도 67%, 적어도 68%, 적어도 69%, 적어도 70%, 적어도 71%, 적어도 72%, 적어도 73%, 적어도 74%, 적어도 75%, 적어도 76%, 적어도 77%, 적어도 78%, 적어도 79%, 적어도 80%, 적어도 81%, 적어도 82%, 적어도 83%, 적어도 84%, 적어도 85%, 적어도 86%, 적어도 87%, 적어도 88%, 적어도 89%, 적어도 90%, 적어도 91%, 적어도 92%, 또는 적어도 93%의 감소를 달성한다.
실시예
참조에 의한 비제한 개시내용 및 편입
본 명세서에 기술된 특정 화합물, 조성물 및 방법은 특정 구현예에 따라 구체성을 갖고 기술되어 있지만, 하기 실시예는 단지 본 명세서에 기술된 화합물들을 설명하는데 도움이 되며, 이들을 제한하고자 의도되는 것은 아니다. 본 출원에서 열거된 각각의 참조문헌은 본 발명에 온전히 참고로 포함된다.
실시예 1: MOE 갭머에 의한 HepG2 세포에서의 인간 타우의 안티센스 억제
안티센스 올리고뉴클레오타이드는 타우 핵산을 표적화하도록 설계되었으며, 시험관내에서 타우 mRNA에 대한 그들의 효과에 대해서 시험되었다. 100 nM 안티센스 올리고뉴클레오타이드와 리포펙틴 시약을 사용하여 배양된 HepG2 세포를 형질감염시켰다. 대략 24 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104 (정방향 서열 GGAGATCATATAGACAATCAAGTGCAA, 본 발명에서는 서열 번호: 10으로 지정됨; 역방향 서열 AGCTTGTGGGTTTCAATCTTTTTATT, 본 발명에서는 서열 번호: 11로 지정됨; 프로브 서열 CACCCACGTCCCTGGCGGA, 본 발명에서는 서열 번호: 12로 지정됨)가 mRNA 수준을 측정하기 위하여 사용되었다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-10-5 MOE 갭머 (gapmer)로서 설계되었다. 갭머는 길이가 20개의 뉴클레오사이드이고, 여기에서 중앙 갭 분절은 10 개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5 개의 뉴클레오사이드를 포함하는, 양 측면 (5' 및 3' 방향으로) 상의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머에서의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다. "개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트(most) 뉴클레오사이드를 나타낸다. 하기 표 1에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자은행 수탁 번호 NT_010783.15) 또는 서열 번호: 2와 같이 지정된 인간 타우 mRNA 서열 (유전자은행 수탁 번호 NM_001123066.3)에 표적화된다. 'n/a'는 올리고뉴클레오타이드가 100% 상보성을 갖는 유전자 서열을 표적화하지 않는다는 것이다. 하기 표 2에 열거된 서열은 100% 상보성을 갖는 서열 번호: 1 또는 2를 표적화하지 않지만, 대신 서열 번호: 3 (엑손 3, 4, 6, 8, 10, 및 12를 건너뛰는, 변이체 mRNA, 유전자 은행 수탁 번호 NM_016841.4) 또는 서열 번호: 4 (뉴클레오타이드 2624000 내지 2761000로부터 절단된 유전자 은행 수탁 번호 NT_010783.14)을 표적화한다.
표 1
서열 번호: 1 및 2를 표적화하는 5-10-5 MOE 갭머에 의한 타우 mRNA의 억제
표 2
서열 번호: 3 및 4를 표적화하는 5-10-5 MOE 갭머에 의한 타우 mRNA의 억제
실시예 2: 5-10-5 MOE 갭머에 의한 HepG2 세포에서의 인간 타우의 용량-의존적 안티센스 억제
타우 mRNA의 뚜렷한 시험관내 억제를 나타내는 상기 기술된 연구로부터의 갭머는 HepG2 세포에서의 다양한 용량에서 선택 및 시험되었다. 세포를 웰당 10,000 세포의 밀도로 플레이팅하고, 리포펙틴 시약을 사용하여 하기 표에 명시된 바와 같이 12.5 nM, 25.0 nM, 50.0 nM, 100.0 nM, 또는 200.0 nM 농도의 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 16 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104를 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다. 타우 mRNA 수준은 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존적 방식으로 뚜렷하게 감소되었다.
표 3
실시예 3: 5-10-5 MOE 갭머에 의한 SH-SY5Y 세포에서의 인간 타우 안티센스 억제
안티센스 올리고뉴클레오타이드는 인간 타우 핵산을 표적화하도록 설계되었으며, 시험관내에서 타우 mRNA에 대한 그들의 효과에 대해서 시험하였다. 안티센스 올리고뉴클레오타이드는 유사한 배양 조건을 갖는 일련의 실험에서 시험되었다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 배양된 SH-SY5Y 세포를 전기천공을 사용하여 7,000 nM 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 24 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한 타우의 억제율로서 표현된다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-10-5 MOE 갭머 (gapmer)로서 설계되었다. 갭머는 길이가 20개의 뉴클레오사이드이고, 여기에서 중앙 갭 분절은 10 개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5 개의 뉴클레오사이드를 포함하는, 양 측면 (5' 및 3' 방향으로) 상의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머에서의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다. "개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트(most) 뉴클레오사이드를 나타낸다. 하기 표에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열(뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자은행 수탁 번호 NT_010783.15) 또는 서열 번호: 2와 같이 지정된 인간 타우 mRNA 서열(유전자은행 수탁 번호 NM_001123066.3)에 표적화된다. 'n/a'는 안티센스 올리고뉴클레오타이드가 100% 상보성을 갖는 특정 유전자 서열을 표적화하지 않는다는 것이다.
표 4
표 5
실시예 4: 5-10-5 MOE 갭머에 의한 SH-SY5Y 세포에서의 인간 타우의 용량-의존적 안티센스 억제
타우 mRNA의 뚜렷한 시험관내 억제를 나타내는 상기 기술된 연구로부터의 갭머는 SH-SY-5Y 세포에서의 다양한 용량에서 선택 및 시험되었다. 세포를 웰당 20,000 세포의 밀도로 플레이팅하고, 하기 표에 명시된 바와 같이 전기천공을 사용하여 1.25 μM, 2.50 μM, 5.00 μM, 10.00 μM, 및 20.00 μM 농도의 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 16 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한 타우의 억제율로서 표현된다. 타우 mRNA 수준은 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존적 방식으로 뚜렷하게 감소되었다.
표 6
실시예 5: 5-10-5 MOE 갭머에 의한 SH-SY5Y 세포에서의 인간 타우 안티센스 억제
안티센스 올리고뉴클레오타이드는 인간 타우 핵산을 표적화하도록 설계되었으며, 시험관내에서 타우 mRNA에 대한 그들의 효과에 대해서 시험하였다. 웰당 20,000 세포의 밀도로 배양된 SH-SY5Y 세포를 전기천공을 사용하여 6,000 nM 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 24 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-10-5 MOE 갭머 (gapmer)로서 설계되었다. 갭머는 길이가 20개의 뉴클레오사이드이고, 여기에서 중앙 갭 분절은 10 개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5 개의 뉴클레오사이드를 포함하는, 양 측면 (5' 및 3' 방향으로) 상의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머에서의 뉴클레오사이드간 연결은 포스포로티오에이트 연결이다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다. "개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트(most) 뉴클레오사이드를 나타낸다. 하기 표에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 NT_010783.15)에 표적화된다.
표 7
실시예 6: 5-10-5 MOE 갭머에 의한 SH-SY5Y 세포에서의 인간 타우의 용량-의존적 안티센스 억제
타우 mRNA의 뚜렷한 시험관내 억제를 나타내는 상기 기술된 연구로부터의 갭머는 SH-SY-5Y 세포에서의 다양한 용량에서 선택 및 시험되었다. 세포를 웰당 20,000 세포의 밀도로 플레이팅하고, 하기 표에 명시된 바와 같이 전기천공을 사용하여 0.625 μM, 1.25 μM, 2.500 μM, 5.00 μM, 10.00 μM, 및 20.00 μM 농도의 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 16 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한 타우의 억제율로서 표현된다. 타우 mRNA 수준은 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존적 방식으로 뚜렷하게 감소되었다.
표 8
실시예 7: 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 MOE 갭머에 의한 SH-SY5Y 세포에서의 인간 타우 안티센스 억제
안티센스 올리고뉴클레오타이드는 타우 핵산을 표적화하도록 설계되었으며, 시험관내에서 타우 mRNA에 대한 그들의 효과에 대해서 시험되었다. 안티센스 올리고뉴클레오타이드는 유사한 배양 조건을 갖는 일련의 실험에서 시험되었다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 배양된 SH-SY5Y 세포를 전기천공을 사용하여 8,000 nM 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 24 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-10-5 MOE 갭머 (gapmer)로서 설계되었다. 갭머는 길이가 20개의 뉴클레오사이드이고, 여기에서 중앙 갭 분절은 10 개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5 개의 뉴클레오사이드를 포함하는, 양 측면 (5' 및 3' 방향으로) 상의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머에서의 뉴클레오사이드간 연결은 포스포로티오에이트 연결 또는 포스포디에스테르 연결이다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다. '화학' 칼럼은 각 올리고뉴클로타이드의 뉴클레오사이드간 연결을 개시한다. 's'는 포스포로티오에이트 연결을 , 'o'는 포스포디에스테르 연결을 나타낸다. "개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트(most) 뉴클레오사이드를 나타낸다.
하기 표에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자은행 수탁 번호 NT_010783.15) 또는 서열 번호: 2와 같이 지정된 인간 타우 mRNA 서열 (유전자 은행 수탁 번호 NM_001123066.3) 또는 서열 번호: 3 (유전자은행 수탁 번호 NM_016841.4)에 표적화된다. 하기 표 10, 12, 및 16에 열거된 각각의 올리고뉴클레오타이드는 본원에 개시된 서열 번호: 5 (유전자은행 수탁 번호 DR002467.1)와 같이 지정된 변이체 mRNA 서열, 서열 번호: 6 (유전자은행 수탁 번호 NM_001203251.1) 또는 서열 번호: 7 (유전자은행 수탁 번호 NM_016835.4)를 표적화한다. 올리고뉴클레오타이드는 100% 상보성과 함께 표적화하는 주요 유전자 서열에 따라 다양한 표에서 제시된다. 'n/a'는 안티센스 올리고뉴클레오타이드가 100% 상보성을 갖는 특정 유전자 서열을 표적화하지 않는다는 것이다.
표 9
서열번호 1 및 3을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
표 10
서열 번호: 5 및 6을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
표 11
서열 번호: 1 및 3을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
표 12
서열 번호: 6 및 7을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
표 13
서열번호 1 및 3을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
표 14
서열번호 1 및 3을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
표 15
서열번호 1 및 3을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
표 16
서열번호 5 및 6을 표적화하는 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 타우 mRNA 억제
실시예 8: 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-10-5 MOE 갭머에 의한 SH-SY5Y 세포에서의 인간 타우 안티센스 억제
타우 mRNA의 뚜렷한 시험관내 억제를 나타내는 상기 기술된 연구로부터의 갭머는 SH-SY-5Y 세포에서의 다양한 용량에서 선택 및 시험되었다. 세포를 웰당 20,000 세포의 밀도로 플레이팅하고, 하기 표에 명시된 바와 같이 전기천공을 사용하여 1.25 μM, 2.500 μM, 5.00 μM, 10.00 μM, 및 20.00 μM 농도의 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 16 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한 타우의 억제율로서 표현된다. 타우 mRNA 수준은 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존적 방식으로 뚜렷하게 감소되었다.
표 17
표 18
실시예 9: SH-SY5Y 세포에서의, 5-10-5 MOE, 5-8-5 MOE, 4-8-6 MOE, 또는 6-8-4 MOE 갭머에 의한 인간 타우 안티센스 억제
안티센스 올리고뉴클레오타이드는 타우 핵산을 표적화하도록 설계되었으며, 시험관내에서 타우 mRNA에 대한 그들의 효과에 대해서 시험되었다. 안티센스 올리고뉴클레오타이드는 유사한 배양 조건을 갖는 일련의 실험에서 시험되었다. ISIS 613412는 또한 검정에 포함되었다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 웰당 20,000 세포의 밀도로 배양된 SH-SY5Y 세포를 전기천공을 사용하여 8,000 nM 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 24 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-8-5 MOE, 4-8-6 MOE, 또는 6-8-4 MOE 갭머로서 설계되었다. 5-8-5 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 4-8-6 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 4개 및 6개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 6-8-4 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 6개 및 4개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 하기 표에서의 각각의 갭머에 대한 뉴클레오사이드간 연결 모티프는, ISIS 613412를 제외하고, 5'-sooosssssssssooss-3’이며, 여기서 각 "s"는 포스포로티오에이트 뉴클레오사이드간 연결을 나타내고, 각 "o"는 포스포디에스테르 뉴클레오사이드간 연결을 나타낸다. ISIS 613412에 대한 뉴클레오사이드간 연결 모티프는 5'-soooossssssssssooss-3’이며, 여기서 각 "s"는 포스포로티오에이트 뉴클레오사이드간 연결을 나타내고, 각 "o"는 포스포디에스테르 뉴클레오사이드간 연결을 나타낸다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다. "개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트(most) 뉴클레오사이드를 나타낸다. 하기 표에 열거된 각 서열은 서열 번호: 1 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 NT_010783.15) 또는 서열 번호: 4 (뉴클레오타이드 2624000-2761000로부터 절단된 유전자 은행 수탁 번호 NT_010783.14), 서열 번호: 5 (유전자 은행 수탁 번호 DR002467.1) 또는 서열 번호: 6 (유전자은행 수탁 번호 NM_001203251.1)에 표적화된다. n/a’는 안티센스 올리고뉴클레오타이드가 100% 상보성을 갖는 특정 유전자 서열을 표적화하지 않는다는 것이다.
표 19
서열 번호: 1 및 서열 번호: 4를 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 20
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 21
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 22
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 23
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 24
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 25
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 26
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 27
서열 번호: 1을 표적화하는 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 28
서열 번호: 1 및 2를 표적화하는 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 29
서열 번호: 1 및 2를 표적화하는 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 30
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 31
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 32
서열 번호: 1을 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 33
서열 번호: 5 및 6을 표적화하는 5-10-5 MOE 갭머에 의한 타우 mRNA의 억제
표 34
서열 번호: 1 및 2를 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 35
서열 번호: 1 및 2를 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 36
서열 번호: 1 및 2를 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 37
서열 번호: 1 및 2를 표적화하는 5-10-5 MOE 및 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 38
서열 번호: 1을 표적화하는 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
표 39
서열 번호: 1을 표적화하는 5-8-5 MOE 갭머에 의한 타우 mRNA의 억제
실시예 11: SH-SY5Y 세포에서 인간 타우의 용량-의존적 안티센스 억제
타우 mRNA의 뚜렷한 시험관내 억제를 나타내는 상기 기술된 연구로부터의 갭머는 SH-SY5Y 세포에서의 다양한 용량에서 선택 및 시험되었다. 안티센스 올리고뉴클레오타이드는 유사한 배양 조건을 갖는 일련의 실험에서 시험되었다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 세포를 웰당 20,000 세포의 밀도로 플레이팅하고, 하기 표에 명시된 바와 같이 전기천공을 사용하여 0.938 μM, 0.1.875 μM, 3.750 μM, 7.500 μM, 및 15.00 μM 농도의 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 16 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다. 타우 mRNA 수준은 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존적 방식으로 뚜렷하게 감소되었다.
표 40
표 41
표 42
표 43
표 44
표 45
표 46
표 47
실시예 12: HepG2 세포에서의, 5-10-5 MOE, 5-8-5 MOE, 4-8-6 MOE, 또는 6-8-4 MOE 갭머에 의한 인간 타우 안티센스 억제
안티센스 올리고뉴클레오타이드는 타우 핵산을 표적화하도록 설계되었으며, 시험관내에서 타우 mRNA에 대한 그들의 효과에 대해서 시험되었다. 안티센스 올리고뉴클레오타이드는 유사한 배양 조건을 갖는 일련의 실험에서 시험되었다. ISIS 613412는 또한 검정에 포함되었다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 웰당 20,000 세포의 밀도로 배양된 HepG2 세포를 전기천공을 사용하여 8,000 nM 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 24 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-8-5 MOE, 4-8-6 MOE, 또는 6-8-4 MOE 갭머로서 설계되었다. 5-8-5 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 4-8-6 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 4개 및 6개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 6-8-4 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 6개 및 4개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 하기 표에서의 각각의 갭머에 대한 뉴클레오사이드간 연결 모티프는, ISIS 613412를 제외하고, 5’-sooosssssssssooss-3’이며, 여기서 각 "s"는 포스포로티오에이트 뉴클레오사이드간 연결을 나타내고, 각 "o"는 포스포디에스테르 뉴클레오사이드간 연결을 나타낸다. ISIS 613412에 대한 뉴클레오사이드간 연결 모티프는 5’-soooossssssssssooss-3’이며, 여기서 각 "s"는 포스포로티오에이트 뉴클레오사이드간 연결을 나타내고, 각 "o"는 포스포디에스테르 뉴클레오사이드간 연결을 나타낸다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다. "개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트(most) 뉴클레오사이드를 나타낸다. 하기 표에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자 은행 수탁 번호 NT_010783.15)을 표적화한다.
표 48
서열 번호: 1을 표적화하는 5-10-5 MOE 갭머에 의한 타우 mRNA의 억제
표 49
서열 번호: 1을 표적화하는 5-10-5 MOE, 5-8-5 MOE, 4-8-6 MOE, 및 6-8-4 갭머에 의한 타우 mRNA의 억제
실시예 13: SH-SY5Y MOE 갭머에 의한 인간 타우의 용량-의존적 안티센스 억제
타우 mRNA의 뚜렷한 시험관내 억제를 나타내는 상기 기술된 연구로부터의 갭머는 SH-SY5Y 세포에서의 다양한 용량에서 선택 및 시험되었다. 안티센스 올리고뉴클레오타이드는 유사한 배양 조건을 갖는 일련의 실험에서 시험되었다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 세포를 웰당 20,000 세포의 밀도로 플레이팅하고, 하기 표에 명시된 바와 같이 전기천공을 사용하여 0.938 μM, 0.1.875 μM, 3.750 μM, 7.500 μM, 및 15.00 μM 농도의 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 16 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다. 타우 mRNA 수준은 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존적 방식으로 뚜렷하게 감소되었다.
표 50
표 51
표 52
표 53
표 54
표 55
실시예 14: 인간 타우 빈발 영역에서의 포스포로티오에이트 및 포스포디에스테르 뉴클레오사이드간 연결을 갖는 5-7-6 MOE, 5-8-5 MOE, 5-9-5 MOE, 및 5-10-5 MOE 갭머의 설계
안티센스 올리고뉴클레오타이드는 상기 연구에서 '빈발(hotspot)'로 식별된 영역에서 인간 타우 핵산을 표적화하도록 설계되었다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-7-6 MOE, 5-8-5 MOE, 5-9-5 MOE, 또는 5-10-5 MOE로서 설계되었다. 5-7-6 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 7개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개 및 6개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5-8-5 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5-9-5 MOE 갭머는 길이가 19개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 9개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5-10-5 MOE 갭머는 길이가 20개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 10개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머에서의 뉴클레오사이드간 연결은 포스포로티오에이트 연결 또는 포스포디에스테르 연결이다. '화학' 칼럼은 각 올리고뉴클로타이드의 뉴클레오사이드간 연결을 개시한다. 's'는 포스포로티오에이트 연결을 , 'o'는 포스포디에스테르 연결을 나타낸다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다.
"개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트 뉴클레오사이드를 나타낸다. 하기 표에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자은행 수탁 번호 NT_010783.15) 또는 서열 번호: 2와 같이 지정된 인간 타우 mRNA 서열 (유전자은행 수탁 번호 NM_001123066.3)에 표적화된다. 'n/a'는 안티센스 올리고뉴클레오타이드가 100% 상보성을 갖는 특정 유전자 서열을 표적화하지 않는다는 것이다.
표 56
서열 번호: 1 및 2를 표적화하는 MOE 갭머
실시예 15: htau 마우스에서의 인간 타우 mRNA에 대한 안티센스 올리고뉴클레오타이드의 뇌실내 투여
선택된 화합물을 인간 타우 형질전환 마우스에서의 ICV 투여에 의한 효능에 대하여 시험하였다 (Duff et al., Neurobiology of Disease 7:87-98, 2000).
치료 및 수술
4 마리 마우스의 그룹 각각에게 200 g의 ISIS 613255, ISIS 613329, ISIS 613344, ISIS 613361, ISIS 613369, ISIS 613370, ISIS 613397, ISIS 613045, ISIS 613099, ISIS 613118, ISIS 613136을 ICV 볼러스 주사로 투여하였다. 2마리 마우스의 대조군은 ISIS 424880로 유사하게 처리되었고 4마리 마우스의 대조군은 PBS로 유사하게 처리되었다. 모든 절차는 이소플로란 안락사 하에서, 그리고 IACUC(Institutional Animal Care and Use Committee) 규정에 따라 수행되었다 마우스 ICV 볼러스 주사에 대하여, 안티센스 올리고뉴클레오타이드는 인간 타우 형질전환 마우스의 우측 뇌실에 주사되었다. PBS 중 300 μg의 올리고뉴클레오타이드를 함유하는 10 마이크로리터의 용액이 약 10초 초과동안 주사되었다. 올리고뉴클레오타이드 투여 이후 14일간 조직을 수집하였다.
RNA 분석
올리고뉴클레오타이드 투여 이후 14일째에, 타우 mRNA 수준의 실시간 PCR 분석을 위하여 RNA를 해마, 척수, 및 피질로부터 추출하였다. 인간 프라이머 프로브 세트 RTS3104를 사용하여 인간 타우 mRNA 수준을 측정하였다. 결과는 대조군과 비교된 인간 타우 mRNA 발현의 억제%로서 산출되었다. 모든 안티센스 올리고뉴클레오타이드는 뚜렷한 인간 타우 mRNA 수준의 억제에 영향을 미친다.
표 57
hTau 마우스에서의 인간 타우 mRNA 수준의 백분율 감소
실시예 16: SH-SY5Y 세포에서의, 5-7-6 MOE, 5-8-5 MOE, 5-9-5 MOE, 및 5-10-5 MOE 갭머에 의한 인간 타우 안티센스 억제
상기 실시예에 기술된 안티센스 올리고뉴클레오타이드, 뿐만 아니라 인간 타우 핵산을 표적화하는 새롭게 설계된 안티센스 올리고뉴클레오타이드를 유사한 배양 조건을 갖는 일련의 실험에서 시험하였다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 배양된 SH-SY5Y 세포를 전기천공을 사용하여 8,000 nM 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 24 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다.
하기 표에서 새롭게 설계된 키메라 안티센스 올리고뉴클레오타이드는 5-7-6 MOE, 5-8-5 MOE, 5-9-5 MOE, 또는 5-10-5 MOE 갭머로서 설계되었다. 5-7-6 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 7개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개 및 6개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5-8-5 MOE 갭머는 길이가 18개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 8개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5-9-5 MOE 갭머는 길이가 19개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 9개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5-10-5 MOE 갭머는 길이가 20개의 뉴클레오사이드이고, 여기서 중앙 갭 분절은 10개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5개의 뉴클레오사이드를 포함하는 5' 방향 및 3' 방향 상에서의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머에서의 뉴클레오사이드간 연결은 포스포로티오에이트 연결 또는 포스포디에스테르 연결이다. '연결 화학' 칼럼은 각 올리고뉴클로타이드의 뉴클레오사이드간 연결을 개시한다. 's'는 포스포로티오에이트 연결을 , 'o'는 포스포디에스테르 연결을 나타낸다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다.
"개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트 뉴클레오사이드를 나타낸다. 하기 표에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자은행 수탁 번호 NT_010783.15) 또는 서열 번호: 2와 같이 지정된 인간 타우 mRNA 서열 (유전자은행 수탁 번호 NM_001123066.3)에 표적화된다. 'n/a'는 안티센스 올리고뉴클레오타이드가 100% 상보성을 갖는 특정 유전자 서열을 표적화하지 않는다는 것이다.
표 58
표 59
표 60
표 61
실시예 17: SH-SY5Y 세포에서 인간 타우의 용량-의존적 안티센스 억제
타우 mRNA의 뚜렷한 시험관내 억제를 나타내는 상기 기술된 연구로부터의 갭머는 SH-SY5Y 세포에서의 다양한 용량에서 선택 및 시험되었다. 안티센스 올리고뉴클레오타이드는 유사한 배양 조건을 갖는 일련의 실험에서 시험되었다. 각 실험에 대한 결과는 하기 나타낸 개별 표에서 제시된다. 세포를 웰당 20,000 세포의 밀도로 플레이팅하고, 하기 표에 명시된 바와 같이 전기천공을 사용하여 0.247 μM, 0.741 μM, 2.22 μM, 6.67 μM, 및 20.00 μM 농도의 안티센스 올리고뉴클레오타이드로 형질감염시켰다. 대략 16 시간의 처리 기간 후에, RNA를 세포로부터 분리시키고, 타우 mRNA 수준을 정량적 실시간 PCR에 의해서 측정하였다. 인간 프라이머 프로브 세트 RTS3104을 사용하여 mRNA 수준을 측정하였다. 타우 mRNA 수준은 리보그린(RIBOGREEN)®에 의해서 측정되는 바와 같은 총 RNA 함량에 따라 조정되었다. 결과는 비처리 대조군 세포와 비교한, 타우의 억제율로서 표현된다. 타우 mRNA 수준은 안티센스 올리고뉴클레오타이드 처리된 세포에서 용량-의존적 방식으로 뚜렷하게 감소되었다.
표 62
표 63
표 64
실시예 18: Htau마우스에서의 인간 타우 mRNA에 대한 안티센스 올리고뉴클레오타이드의 뇌실내 투여
선택된 화합물을 인간 타우 형질전환 마우스에서의 ICV 투여에 의한 효능에 대하여 시험하였다 (Duff et al., Neurobiology of Disease 7:87-98, 2000).
치료 및 수술
4 마리 마우스의 그룹 각각에게 200 g의 ISIS 613099, ISIS 613361, ISIS 613370, ISIS 623782, 또는 ISIS 623996를 ICV 볼러스 주사로 투여하였다. 2마리 마우스의 대조군은 ISIS 424880로 유사하게 처리되었고 4마리 마우스의 대조군은 PBS로 유사하게 처리되었다. 모든 절차는 이소플로란 안락사 하에서, 그리고 IACUC(Institutional Animal Care and Use Committee) 규정에 따라 수행되었다 마우스 ICV 볼러스 주사에 대하여, 안티센스 올리고뉴클레오타이드는 인간 타우 형질전환 마우스의 우측 뇌실에 주사되었다. PBS 중 200 μg의 올리고뉴클레오타이드를 함유하는 10 마이크로리터의 용액이 약 10초 초과동안 주사되었다. 올리고뉴클레오타이드 투여 이후 14일간 조직을 수집하였다.
RNA 분석
올리고뉴클레오타이드 투여 이후 14일째에, 타우 mRNA 수준의 실시간 PCR 분석을 위하여 RNA를 해마, 척수, 및 피질로부터 추출하였다. 인간 프라이머 프로브 세트 RTS3104를 사용하여 인간 타우 mRNA 수준을 측정하였다. 결과는 대조군과 비교된 인간 타우 mRNA 발현의 억제%로서 산출되었다. 모든 안티센스 올리고뉴클레오타이드는 여러 조직에서 뚜렷한 인간 타우 mRNA 수준의 억제에 영향을 미친다.
표 65
hTau 마우스에서의 인간 타우 mRNA 수준의 백분율 감소
실시예 19: 인간 타우를 표적화하는 안티센스 올리고뉴클레오타이드의 설계
ISIS 번호 603054를 인간 타우를 표적화하도록 설계하였다. ISIS 번호 603054의 핵염기 서열 및 연결 화학성질은 하기 표 66에 나타낸다. ISIS No. 603054는 5-10-5 MOE 갭머이다. ISIS No. 603054는 길이가 20개의 뉴클레오사이드이고, 여기에서 중앙 갭 분절은 10 개의 2'-데옥시뉴클레오사이드를 포함하고, 각각 5 개의 뉴클레오사이드를 포함하는, 양 측면 (5' 및 3' 방향으로) 상의 윙 분절에 의하여 플랭킹된다. 5' 윙 분절 내의 각각의 뉴클레오사이드 및 3' 윙 분절 내의 각각의 뉴클레오사이드는 2'-MOE 변형을 갖는다. 각각의 갭머에서의 모든 시토신 잔기는 5-메틸시토신이다. "개시 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 5'-모스트(most) 뉴클레오사이드를 나타낸다. "정지 부위"는 인간 유전자 서열 내에서 갭머가 표적으로 하는 3'-모스트(most) 뉴클레오사이드를 나타낸다. 하기 표 1에 열거된 각각의 갭머는 본원에 개시된 서열 번호: 1과 같이 지정된 인간 타우 게놈 서열 (뉴클레오타이드 9240000 내지 9381000로부터 절단된 유전자은행 수탁 번호 NT_010783.15) 또는 서열 번호: 2와 같이 지정된 인간 타우 mRNA 서열 (유전자은행 수탁 번호 NM_001123066.3)에 표적화된다.
표 66
hTau 마우스 및 WT C57Bl6 마우스에서의 체내 연구
실시예 20: 인간 타우를 표적으로 하는 올리고뉴클레오타이드의 마우스내
체내
분석
하기 표에 나타난 올리고뉴클레오타이드는 타우를 표적화하도록 설계되었다. 인간 타우 형질전환 마우스 "hTau" (Duff et al., Neurobiology of Disease 7:87-98, 2000; Davies et al. J. Neurochem. (2003) 86, 582-590) 또는 야생형 WT C57Bl6 마우스인, 마우스는 3 또는 4개 마우스 그룹으로 분리되었다. 마우스의 각 그룹에서의 각 마우스에 하기 표에서의 올리고뉴클레오타이드를 각각 300ug 또는 200ug의 단일 ICV 용량으로 투여하였다. 주사후 3시간 째에서, 각 마우스를 7개의 상이한 기준에 따라 평가하였다. 7개의 기준은 (1) 마우스가 밝고, 기민하고, 그리고 반응성이 있었고; (2) 마우스가 자극 없이 서있거나 웅크리고 있었고; (3) 마우스가 자극 없이 임의의 움직임을 보였고; (4) 마우스가 들어올려진 후 정방향 움직임을 나타내고; (5) 마우스가 들어올려진 후 임의의 움직임을 나타내고; (6) 마우스가 테일 핀치(tail pinch)에 반응하고; (7) 정상 호흡이다. 상기 7개 상이한 기준에 대하여, 각 마우스는 그 기준을 만족할 경우 0의 서브스코어가 주어지고, 아닐 경우 1의 서브스코어가 주어졌다. 모든 7개의 기준을 평가한 후, 서브스코어를 각 마우스에 대하여 합하고 이후 각 그룹에 대해 평균치를 구하였다. 예를 들어, 만약 마우스가 300 μg의 ICV 용량 투여 후 3시간째에 밝고, 기민하고, 그리고 반응성이 있고, 다른 모든 기준을 만족한다면, 총계 스코어는 0이 될 것이다. 만약 다른 마우스가 300 μg의 ICV 용량 투여 후 3시간째에 밝고, 기민하고, 그리고 반응성이 있으나, 다른 모든 기준을 만족하지 못한다면, 총계 스코어는 1이 될 것이다. 염수 처리된 마우스는 일반적으로 0의 스코어가 주어진다. 결과는 각 처리 그룹에 대한 평균 스코어로서 하기 표 67에 제시된다. "ND"는 데이터없음을 의미한다. 이러한 결과는 ISIS 613099, ISIS 613361, ISIS 613370, ISIS 623782, ISIS 623996, ISIS 424880, 및 ISIS 603054가 잘 용인된다는 것을 나타낸다.
표 67
hTau 마우스 및 WT C57Bl6 마우스에서의 체내 연구
실시예 20: 인간 타우를 표적화하는 안티센스 올리고뉴클레오타이드의
체내
분석
스프라그 다울리(Sprague Dawley) 래트를 각각 4마리의 래트 그룹으로 분리하였다. 각 그룹의 래트에서 각 래트에 ISIS 613099, ISIS 613361, ISIS 613370, ISIS 623782, ISIS 623996, ISIS 424880, 또는 ISIS 603054를 단일 1mg 척추강내 (IT) 용량 또는 단일 3mg 척추강내 (IT) 용량으로 투여하였다. 주사 후 3시간 째에, 몸체의 7개의 상이한 부분의 움직임을 각 래트에 대해 평가하였다. 7개 몸체 부분은 (1) 래트의 꼬리; (2) 래트의 후면 자세; (3) 래트의 뒷다리; (4) 래트의 뒷발; (5) 래트의 앞발; (6) 래트의 후면 자세; 및 (7) 래트의 두부이다. 상기 7개 상이한 몸체 부분에 대하여, 각 래트는 만약 상기 몸체 부분이 움직일 경우 0의 서브스코어가 주어지고, 상기 몸체 부분이 마비될 경우 1의 서브스코어가 주어졌다. 모든 7개의 몸체 부분이 평가된 후, 서브스코어를 각 마우스에 대하여 합하고 이후 각 그룹에 대해 평균치를 구하였다. 예를 들어, 만약 3 mg의 IT 용량 투여 후 3시간째에 래트의 꼬리, 두부 및 모든 다른 평가된 몸체가 움직일 경우, 총계 스코어는 0이 될 것이다. 예를 들어, 만약 3 mg의 IT 용량 투여 후 3시간째에 다른 래트의 꼬리는 움직이지 않으나, 모든 다른 평가된 몸체가 움직일 경우, 총계 스코어는 1이 될 것이다. 염수 처리된 래트는 일반적으로 0의 스코어가 주어진다. 상기 범위의 상부 제한에서의 스코어는 독성을 의미하는 것일 수 있다. 결과는 각 처리 그룹에 대한 평균 스코어로서 하기 표 68에 제시된다.
표 68
1 mg 및 3 mg IT 볼러스
체내
연구
SEQUENCE LISTING
<110> Isis Pharamceuticals, Inc.
<120> COMPOSITIONS FOR MODULATING TAU EXPRESSION
<130> BIOL0227WO
<150> 61/856,551
<151> 2013-07-19
<150> 61/879,621
<151> 2013-09-18
<150> 61/885,371
<151> 2013-10-01
<150> 62/014,486
<151> 2014-06-19
<160> 2584
<170> PatentIn version 3.5
<210> 1
<211> 141001
<212> DNA
<213> Homo sapiens
<400> 1
aatttataaa ggaaaaaggt ttaattgact cacagttcag catgtctggg gaagtgttag 60
gaaacttaca atcatggcag aagagaaagc aaaccatcct ttctcacatg gtgacaggaa 120
gagcaaagcg gggtaagccc cttacaaaac caccagatct catgagaact cactatcacg 180
agaacaccat ggaggtaact gcccccatga ttcaattacc tcccaccagg tccctcccac 240
gacatgtggg gattatgcga actccaactc aagatgagat ttgggtgggg acacagccaa 300
accatatcag aagcttaacc ttctttggag catgattatt cagttgaacc taagttcagt 360
agtcacccag ttatgctgtc ttcagctact attttccata tgtttctcaa acatctgata 420
tatcacactg gctagtgcac tttcttccac cagcatacca tctcaattta ccactttaac 480
aattggactg ccactttgtg tcagggacta tctgtgctcc aactactaca agtgataagg 540
tcctcactga cagccaggga gcaagtgatc cagctctaaa actcacctta tcatctgctt 600
tcctagacca ctcctaacaa ccaactattc tgggttgagt tctccaagag gcagagagtt 660
caggatacag aatgttgttt tgtttttgtt gttgttgctg ttgttgtttg tgtgtgtgtt 720
tgggcttttt tgagacggag tctcactctg ttgcccaggt agaagtgcag tggcatgatc 780
tcagctccct gcaacctcca cctcctgggt ttaagtgatt cccctgcctc cacctcctga 840
gtagctggga ctacaagtgt gcgccaccac acccagctaa tttttgtgtt tttagtagaa 900
atggggtttt accatgttgg ctaggctgct cccaaactcc tgacctccag tgatccacct 960
acctctgcct cccaaagtgc tgggattaca ggcgtgagcc accacaccca gcccagaatg 1020
tttattagaa tgcacaatta ataccagagg cagtggggaa ggaaggactg agcagaggag 1080
gaagttgagt tgtgattcaa cccaacaact gcctggctgg catggggagc tctggagtta 1140
aatagggcca tcagactttc ccagtgtggg gccaacatga ctgggtcttt atacccccac 1200
ctctgtcagt cactcaacgt ggtctccctg caacaaggtg actcttgcag ccgagacaat 1260
ccctgaaggg acagagggct gaagcctgtc tgccaacagc actcccagtg gctggaacaa 1320
gtccttccct ataggggaat ctgggcggca cacctccatc tccatgtcca tcacatacga 1380
tatcacagac atttaaatat tttgataact gtacataaga gtttccttta taatcttata 1440
gatcttattt tatgcatttg aaaatattct tctgagacag ggcttttatc atattgccat 1500
agggtgccac gatataaaaa aggttaaata ctctctgatt cagaagtatc caatgatgac 1560
ttctctctca tgcatttaat tgaaaatctg gtttttctcc ttctctgcta gttctctacc 1620
tctctcccca cctcccacat catagcctat tcacatatgt ctgaatctca tgatagacaa 1680
gttcaggttc ttttcccagg ttctttttac cacatccccc cacccccaca taaaaagtat 1740
atatggcaca gcctaggttc cacccaaatc ctttctcctc ttcttcctgg gcccacaact 1800
ctcctacata cattggtata ccttgcgctt agggatggcc atgtgactaa gttctaacag 1860
tggaacatga tcagatgcca cttccagcct ctaagacagc cagtgtgttt cctccataag 1920
ctccttctct tcctcccaac tggagactct aaatgatgac cctgcctcaa gcaagcaaac 1980
aacaagtccc tcaggggtgg tgtaggctgc aaatggaagg agcttgagtc ccaaaccttc 2040
cacggagaag gctggctacc aacctggatc actcacccaa gactgctcga agagttggtt 2100
tgaaccattg tgttttgggg tctatttatt acaacagttt agcttgcttt gtgaatagat 2160
ttagtggcag agcctccaaa ttctatagat acattgatct cagtcctaac cgcatctgga 2220
acaccattaa ataaaggaat tgcaaaccca gagaaggtaa tgaatttgtc taaggtcata 2280
caagatggct aggatcagga cccaactctc cagttttctt tcttctctgc tattctgcct 2340
tctgtgatcc tacataagtg ggcatgattg tataacatat gcggccatga gatttctctt 2400
tcagcaagag aaagggacag gaagaaagag agggaatgca ttttcttggc ctgaattagt 2460
gtgagccatt agttacctac attgactaaa ttatctggaa tgaacattca actctacatc 2520
acatatagtt aaaatgacag atctgcttaa gattgtttct agcatacgtt atttcaattt 2580
aggcaaatgt gaccattcag tgtgagggga ccatactgtc attaggtccc tgtcagttct 2640
caattatact gttatcttag agggggaaaa atgtgaaatt tgaatgtaga cgagtgttga 2700
tttgactgct acagtttatt ttacgtatag aaataaaata atgtgtagca aaagcattat 2760
tacaaagatg ataatgaaat aactagtatt tataatagta taatagtata gtatttataa 2820
tagtatgata gtttaatgac tatttgtcag atgttgtgta agaaacttta tacacacaca 2880
cacacacacc tcatttaatt cctgtatcaa tcaggataca ggacgctgtg gtaacaactc 2940
ctcaaatctc ggtggcttgc acaacaaatg cttatttctt tttttttttt gacaccaagt 3000
cttgctctgt aacaggctgg agtgcaatgg tgcaatctcg gctcactgca gcctctgcct 3060
cctgggttca agcgattctc ctgcctcagt ctctcgagta gctgggaaca caggcacgcg 3120
ccaccacatc tggctaattt ttgtgatttt agtagagatg ggatttcacc atgttgctca 3180
ggctggcctt gaactcctga cctcaagcga tccacccacc tcagcctccc aaagtgctgg 3240
gattacaggc atgagccact gcgcccagcc ccaaatgttt atttcttgct catgtgacat 3300
gtacttcctc gagtttttcc ttcctgagat ctaagctgaa ggaacagctc tctggagcca 3360
cgccattctg gtggcggaaa ggaagagtaa aagtggtaga accttgcaat gctcttgaag 3420
cgcctatttg gaatgtctac atcatgtaaa tggtaatgga caagtatgta taatccccac 3480
accaaaaaaa ggggacacta ttggggacaa taaccacatt tcaatgctgc aagacggata 3540
ttgactgcac ccccttccca ctttcagaaa gaagaagagt aattttgctg aactccttct 3600
agagactgga aatgtccctt ccagttgggg tgattaggga aggctttggt aaaatttgag 3660
ctagagtttg aaggttaggt agactactgg tgggtgaaga aagaacaagg acctttgtag 3720
gcaaaggaaa acctcagaat tacagaggtg gaaaaagagt tctagtcaag ccacttcagc 3780
tggctacaga gtaggtggga aagaaaatgg gaggacaagg gctcagatga tggggggttg 3840
gggcattggg gggacacttg aaagctaaac taaggggttg aacttaattt aggaggcagt 3900
tagaagcttt tacatatttt tgagcaagag agtgacataa ttaaaatgat ctgggccagg 3960
tgtggtggct cacacctgta atcccagcac tttgggaggc tgaggagctt gggtcacctg 4020
aggtcaggag atcgagacca gcctggccaa catggtgaaa tcccgtccta ctaaaaatac 4080
aaaaattagc cgggagtggt ggcatatgcc tgtaatccca gtagctggga ggctgagaca 4140
ggaaaatcgc ttgaacccgg gaaacaggtt gcagtgagcc gagatcgtgc cactgcactc 4200
cagcctgggc aacagagcga gactccatct caaaaaaaca aaacaaacac acacaaaaaa 4260
ccaaaaataa ataaataaaa tgatcacttc tgaatactga tctaactagg ggttgcaggg 4320
tgggctgata tagggagaaa ctggagagca aggagatcac taaggtccct acatgtccag 4380
aaccaagata gaggtcttga actaggatgg tggcagttag aacaacaaca acaaaaagtc 4440
aattccaggc tgagtgcagt ggctcatgcc tgtaatccca acgctttggg aggctgaggt 4500
gggagttaga aagcagcctg ggcaacactg caagacctcc tctctaaaaa aaaaaaaaaa 4560
aaaaagttag ccaggtgtgg tggtgcccac ctgtagtccc agcaactcag aaggctgagg 4620
tgggaagatt gcttgagccc caggagttca agcttgccgt gagctacgat tgtgccactg 4680
cactccagcc tgagcaagac cttgtctcca aaaaaaggtc aattccactg acttttctaa 4740
ggtgtacacc atcaaggggc agctccatct ccaggccatt ggctcatgag acattctgta 4800
gtcagaaggc tagggcagat tgctttgagc aagcccccat ggtggttctc actcctactt 4860
ctttgggtat atgcccctct gtttaaaaat aaagttaata tgcatttaaa aaaaaaaagg 4920
agaaaaaggt cagttccaga aactgtgtga ataaagcatt ttacttgctt tttctattaa 4980
tctataacat atgttgattt tttaaaaaga atataagagc tatgcaaatt ggagcttcaa 5040
gacaacttcc catctcccta ggaggagatg gctgccctaa acccccctac atagaaatca 5100
tcccactgct tgggcttaaa cttgatgttg gggaaatgaa aaatccaagc taaggccgaa 5160
gcctggggcc tgggcgacca gcagaatgag gaccactggt cagtttcagg ctgaggtgcg 5220
tcttccaggg gacaatctct agctggccct taaacattca gacttcaagc tctatttaca 5280
gcataaaggt gtttcaaaag acgtgataca aataactgca aatgctctgc gatgtgttaa 5340
gcactgtttg aaattcgtct aatttaagat ttttttttct gacgtaacgg ttagattcac 5400
gtttcttttt ttttaagtac agttctactg tattgtaact gagttagctt gctttaagcc 5460
gatttgttaa ggaaaggatt caccttggtc agtaacaaaa aaggtgggaa aaaagcaagg 5520
agaaaggaag cagcctgggg gaaagagacc ttagccaggg gggcggtttc gggactacga 5580
agggtcgggg cggacggact cgagggccgg ccacgtggaa ggccgctcag gacttctgta 5640
ggagaggaca ccgccccagg ctgactgaaa gtaaagggca gcggacccag cggcggagcc 5700
actggccttg ccccgacccc gcatggcccg aaggaggaca cccacccccg caacgacaca 5760
aagactccaa ctacaggagg tggagaaagc gcgtgcgcca cggaacgcgc gtgcgcgctg 5820
cggtcagcgc cgcggcctga ggcgtagcgg gagggggacc gcgaaagggc agcgccgaga 5880
ggaacgagcc gggagacgcc ggacggccga gcggcagggc gctcgcgcgc gcccactagt 5940
ggccggagga gaaggctccc gcggaggccg cgctgcccgc cccctcccct ggggaggctc 6000
gcgttcccgc tgctcgcgcc tgcgccgccc gccggcctca ggaacgcgcc ctcttcgccg 6060
gcgcgcgccc tcgcagtcac cgccacccac cagctccggc accaacagca gcgccgctgc 6120
caccgcccac cttctgccgc cgccaccaca gccaccttct cctcctccgc tgtcctctcc 6180
cgtcctcgcc tctgtcgact atcaggtaag cgccgcggct ccgaaatctg cctcgccgtc 6240
cgcctctgtg cacccctgcg ccgccgcccc tcgccctccc tctccgcaga ctggggcttc 6300
gtgcgccggg catcggtcgg ggccaccgca gggcccctcc ctgcctcccc tgctcggggg 6360
ctggggccag ggcggcctgg aaagggacct gagcaaggga tgcacgcacg cgtgagtgcg 6420
cgcgtgtgtg tgtgctggag ggtcttcacc accagattcg cgcagacccc aggtggaggc 6480
tgtgccggca gggtggggcg cggcggcggt gacttggggg agggggctgc ccttcactct 6540
cgactgcagc cttttgccgc aatgggcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 6600
tgtgtgtgtg gaggggtccg ataacgaccc ccgaaaccga atctgaaatc cgctgtccct 6660
gccgctgttc gccatcagct ctaagaaaga cgtggatcgg gttctagaaa agatgactcc 6720
ctgcacgccc ctccctgcac ctcccgagca gtgattccga cagggccttc actgcccctg 6780
attttaggcg ggggccggcc ccctcccctt ttcctccttc agaaacccgt aggggacatt 6840
tgggggctgg gagaaatcga ggagatgggg aggggtccac gcgctgtcac tttagttgcc 6900
cttccccctg cgcacgcctg gcacagagac gcgagcagcg ccgtgcctga gaacagtgcg 6960
cggatcccac tgtgcacgct cgcaaaggca gggttcacct ggcctggcga tgtggacgga 7020
ctcggcggcc gctggtcccc gttcgcgggc acgcacagcc gcagccacgc acggatgggc 7080
gcggggctgc aggtgcatct cggggcggat ttctttctca gcgctcggag cgcagggcgc 7140
ccggcgtgtg cgctccctgc cggaggcgcg gggctggcgc gcagggctcg cccctcactg 7200
cggcagtggg tgtggaccct ggtgggcgag gaagggggag gataggctgt gcctcctccc 7260
actcccgccc ccagcccccc tttttttccc cctcggaacg cgaggtgcca tcttttttcg 7320
gcgtgtcacg tctttacggt gccatgccaa accgggtggc cgggcttcat aggacagggc 7380
ggggcctggc attaaaggga gggggacaat cagcgctgaa atcttggcgt tttgctgctg 7440
cgggcgtgag cactgggggc gttcgcccag caccttcttc gggggctctt tgctttgtct 7500
gtagaggtta cgtgatctgc gctcccagcc ctggtttctg gcttttattc tgagggtgtt 7560
cagtcaacct cccccctacg cccatgcgcc tctctttcct ttttcgctcc tcatttccga 7620
gcccattgtt ggatctcgag gcttgctggg ttcgatgaac tcgagtcaac cccccgaccc 7680
ccggcacgca tggaacgggc gtgaccgcgc gcagcctcgt ctcggagtct gccggcgccg 7740
ggaagcttct gaagggatgg gattcgagtc tccgtgcgcg ctgcgggcgg cggcagaggg 7800
atctcgcccc tccctacacc ccaagtgtcc tgagggccac gccacaccag gttgcccagc 7860
gagggacgct ggctacccat ccggggatgg gtggggagcc ctggcggggc ctctccggct 7920
ttacgccctg ttgcttcgcc tggccggaga atgtgaggaa ggggcataag gttactggtg 7980
cttcggccac acccatcttt ctgagcccac tggactgggc gcagaggggg gattgccatg 8040
gaaaccacag gtgtccggag aggggatctt ggggctggcc tcaccccttc cctgcggaga 8100
ttggggaccc tggggtaggg ggagccgcgc ccagtcggcc tcctggagga cacgggagga 8160
agccccgaac ccccgcgcct gaggctgttt ctgattggcc cctggaggcc gcagacacgc 8220
agataggcgg ccctgggtgt atttttatta atattatgtc cgtactgatt aatattattt 8280
atcttaaata aatttcaccc gtgtccaagt tcaccgcgcc cccaaaaccg agtctggggc 8340
ggcaggggga actcctggcc aacgaatcca tgcctcgccc tcctgtgatg aacctggtac 8400
gcacggtttt ctggttaatt ctatcgctga aaactggtgc ggggggcgca cttctgagac 8460
ggaagagcat ctaggagctg aatcctccac gcgggtcgcc caggttgatc tgaatttctg 8520
gggaatggct tggctgcccg cccgggacca ggccgaccct ccttgacggt ggcgtagagg 8580
gctggagcct gggtactgcg aggctcctcg catggctggg cccgccgcga ggggttgcag 8640
agcggctcag ggatcgattc aagcatcgtc tctcctccct cgcccccaga cagagctggg 8700
cgcggggttc cccttccaga tggagcgagg gtctcggggt ggccccggaa aaggggagcc 8760
cgcggccacg gctacgtatt gccatctcgc gagcagagat gtcacctcct gcctttggag 8820
gaaagggagc ccggtgggga tgagcgcatt tagcccaatg ctgggaacaa agcgcactcc 8880
gcgcttctgc gatttcgctc cattttgaaa tgtgttggcg ctttggtggg gccgctgcgg 8940
tgggcaaggc cgggggcgct gttaatggag gaacctcagg gggacggtcc ttcgtaggaa 9000
actctatcct ggctctgcgc gcgctttaag gaaatggctt ccctccagga cctcgaggga 9060
tgcagctttt gcgcggatga cggtggggtg ctgaaccagc cggtgcgcct ctggaaatgt 9120
ctgggcacgg atcctggggc catcgacgac tcctccccat tcccagcagg cgggagctct 9180
tacattccga gcgagtgacc cctctcaccc tctggcgctc acacacctgt aactccaaac 9240
ctccgtctca gaatggtcca ggctggaagg gatgatgggg gctccgacag cgactgccta 9300
gctcacccct ctgcgtgctc aggctccagg ctcagcagga ccaatttgag ttctatctga 9360
tccccctcgg ccccttaact gacccatcct acaggagaca gggaaatgtc tttcctaccg 9420
cggttgattc tggggtgtca ttttgtgttt tgtgatggct gcttatattt actgtataag 9480
cattgtattt actgtataag cattgtatta taattactgt ataagctgct tatatttact 9540
gtataagcat ctccaaatcc tccctctacg taaacaaatt aatggataaa cagataagtg 9600
tatcccctgc ccccacccct gctacgcagg tccggagtga ctcttgaagc tcatacattc 9660
cttggccaag tttgcttctc taacagatgt ttatatagca ataacctggc ttggctcttg 9720
ggttcacctt tggacgattt ggggaagggg cttgttggct ttgctgggtt ttggatgagt 9780
gacagtccat gactgttcct gctggaaggg cgtgactttt aagtggtttc taatatcagg 9840
cattgctcct ccgacaggaa caaaagaaat ggatactgcc cataaattgt tagaaaactt 9900
agaatcgctt tgattgagga aaggttagat ttattccggt tggaaaaagt ggcctttcta 9960
ttaaacgtgc cctttgaccc tcatgccctt ggaggtcggt gccagcctgg agatgggata 10020
agattgtggt tttccttctg cctttttaac atctgttgtt acagtccatt tgttgaaaat 10080
ttaaagaaac tgttttattc cactttccct cagcatttat gtgtgtggtt tcagtagctc 10140
tgtggctata tgtacgaaca cgtgttattt ttccaattgg acatgtgata attttccaac 10200
tggaccttgc cttctattga tgtatttatt tagcatcttc cttactccct ccttgaaaaa 10260
gaatcactca aaaacaaata aaaacagccg taggggccta atacagtgct agacatacaa 10320
gaggtattcg gtccatacca aatggatttt atccatgaag gataaatggg gaaatacagt 10380
gggaagcagg tgggaaactg cgtttgactc tgctctttcc tccaccacca ctttcctcat 10440
caccgtgttc agagaccccc aaagccccct cacactccca gaaacacccc cctggccact 10500
cctaacttgc catgcccagg agttaggtgc ttccactagt gacatggagc tggcgtttgg 10560
ggggcacctc agcaggtgac gggaagagaa gaccccagcc tcaccagctg ggctgcagca 10620
gggagaggag tcctcatgtt ccagcaggga ctctcagctg ttttcctgta aaaccatggt 10680
tctcaactgg gggccactga gatgtctaga gagatgtttt tgttttcaca actcggggag 10740
ggtgctactg acatcttgtg ggtagaggcc aggaatgctg ttaaacatcc tacaaggaag 10800
gcacaggaca gtctcctaca tcaaaatatg acccagtccc aatgtcacca ctgctggggt 10860
tgacactggc actgctatct taattacatt cattgagtgt cttttaggag gccctattct 10920
aagtgcttgc taagattatc tcatttaatc ctcacaacac ttccgctatg tagcaggtgc 10980
tgttattatc tccgtgatgg ggaaactgaa gcacagagag ggttagtaac ttgctaaagg 11040
tcacagagcc agtgggtggt ggagctggtt gcctgacact agttccctcc cctctcagcc 11100
acatgtgggt ttacttggcc attgtggact agtctgggaa cccagatatg atctataaca 11160
ttgacccagt agaatattga ttccaaaacc actgtctcac aaatgaattt ttacaagagt 11220
ctgtaatcgg agcatgaccc agaataaggt tagggagatg tggagttaaa gctctcaatt 11280
tcttatctgg ccccgacaca gagagcaagg catttcactc tacattggtg ctctgtttat 11340
aaaacaaaga gcaaatatct cttcctaagg tccttaaacc tcttccccca atccagggtt 11400
tctggactgc tctgccatat gacggggcag ctggtttgat tgacccaggg aaggctggaa 11460
atcaagactg ggggatcaag acgtagattc agtgtggcca aggtcaagtc tctgaggttt 11520
agggacatca gatccccagc ttaggttctg tacctcggca aggtgaaagc gttggcgccc 11580
actgatgagg cctgctctga gattgtgggt gtgggttgag ttgggtgggc ataggcaagt 11640
cctcttgtaa gaatcttttg gcaaagatgg gcctgggagg cttttctcac ttcctggggc 11700
ccaggctttg caataagtat tccattatac tgtggtacct tggggctacc tgagaatcct 11760
ctgtctcgcc cctgttgcct tgccaaagag tttgctgtcc aagaattcct ttcctgtctc 11820
caggtgccat gctcctgcca cctctgccag gttccctgcc tgcccagatg gctcccaact 11880
gagtgtgagg aggaatttga gacaggtttt gagctttctg ggttctccag ttaggaaact 11940
ttctgtaagc atgcagatag aatgggcttc agcaaaatac aaactcgaac aacttccatg 12000
tatagtccct taattttctt tgcttttttc atatttcatc aggctccatg ctgagcccaa 12060
tcagggaccc gatagaaatc caaacaccat gtcagcgagt ccccaagaaa tgcattttgt 12120
gccaaggcta ttcaaggaag gtttgggagc agctcaaggg cagacactgt taccctcccc 12180
caggtcccca gtgcagggca gtgttctgca tgtggaggca gtttggccta atggttaagg 12240
aggtaggctc tgatcgggcc tcctgggcac aaatcccagc tccctgctca ctgtgagacc 12300
taagccatat tgtttagctg cttggagagt tttttgtcat ccacaacttg gagtatgatg 12360
gtacctgtct cacgggttgc catggggttc acacaagcta acccggtact cactagggcc 12420
aagcacatag taactgctca gtaaatggca tcatcggcgg tgtcctgtgg atgagtgctt 12480
gtgattggct gaatgaccag aggggtctaa agatcctggt gatggaatca gttgtacaga 12540
taaattgtta cactgagtag ggatcaagat aggaaaagtc ggcaactacc cagctcccct 12600
gcaccaaact gggcagaagt ggatcctctg aaaattgcac acacccatgt ttaaatgtac 12660
acacagaact cttgccacag gcaagcggag atttgtcatc tgctgtccct gcctcatctt 12720
cttcctgaaa tccactccat gccaggaata aactgcatgc tctccaccag cccaaactga 12780
cctgccttcc cgccagccat cccgggcagg gtgacctggc ttagtacatc gggttcagag 12840
atctttccag tttactcgtt gaataaaaag tgagggctga tcgagaaagt aatggcagtc 12900
agggaaggcg aaggaggtaa agaagagatt ttacaaatga agtaattcaa cagagtgctg 12960
acattggtaa actggcaaac agatttcagg gtggttggtt gagagtagag tagaaaagga 13020
ttaaataaag caaacttgtg gtgtactgaa tcttaggaat tccatgtatc caataagtat 13080
agtcatttat gaattaataa attcggccta agaagccttc ttatcgctta aatcaagact 13140
aagtaacaat atatcagttt taaaaagtca ttatatcaga aaatcattta aatgatacac 13200
atagatttcc aagattttac tttaaccgaa actatataaa tgtgaatttg ttcacccatc 13260
ttttgacaca gggctcaggt cttctcttgg tgtctggatc agccagttga aatttcttgt 13320
ctgttttgcc tatgccacat taataatgca ctgtctgggt cctccgattt cagtttggat 13380
tttgggttta cattgtggag tcatctgaat gcagaatcct tcagggattt tacttttttt 13440
tttttttttc atggtcttta ccatcccatt tgatagtaaa tattactcac ctttatgaag 13500
tctttccaaa acattcaact aaattttctt aaaatcattg aatgatttga agagcttatt 13560
cctcagcact tttactccat cagcttgcac cttatttttt aatctttttt tgagacggag 13620
tctcgctcta tcgcccaggc ttaagtgcaa tggcgcgatc ttggctcact gcgacctcca 13680
cctcctgggt tcaagcaatt ccgcctcagc ctccgccgta gccgggacta caggtacaca 13740
ccataatgct cggctgattt ttgtattttt gtagggatgg ggtatcgcca tgttggccag 13800
gctggtcccg aacttctgac ccaagtgatc cacccacctc ggcctcccaa agtgctggga 13860
ttacaggtgt gagccaccgc gcccggccag cttgcacctt atttaggata tgtgattatt 13920
atagcaagtc tggtgtacat acaagatttt gaatgggcac agatgacctt tagtaagtgc 13980
ttggctgtga taagaggcag tcctgactgc agatcaggct gtgtggaccc cagccttgca 14040
tgtttacaga ccttcatgtc ttattcttac agggtatcag aagaacacct actggggaaa 14100
cttataaatt agtaaaaggt gggcattctc cccgcccatc ttctgtctgt ctgccaggac 14160
tagcacagca ctttgaagtc attcacatag aatcccaact taagagggta aaatcctcct 14220
caacagactg aaaataagtt taaattccct ttgctatatt aactcccctg aggaaagagt 14280
cttagatcaa tgtccaacac taaaaacagt tttaaatcag caagtgagaa ttaaatctga 14340
agcaattgat aataatgttt cattcattcc tctcctttgg ccccgtccac cctactgcta 14400
aatccaggca tcaaagagaa gagggacata attatctcta gtcccagctg ctggttttcc 14460
ttccagccta tggcccagtt ttctgtttta ctgagaaggc tggtgatgtt atcttgggat 14520
ctaagtctgc agtttcacca caaaaagtcc agggatgcac tttcatgctt gtgtcctcct 14580
ccctgggata gcaaggatat tagaagaccc ctggctctgt aattgcttgt catgtgctct 14640
acagacgcca cagaatgcca agaacgaagt gctgggaagg acaaattcat ggaaccgtgg 14700
gacggtgctc ctcccccagc gtaaaggaca gctcctcctc ctgaattgga gccagcgttc 14760
taaatcatgt gtcaacagag ttgtcctgga tcggatccag ttctgccatt gatttgcagg 14820
tcatttcagt ggtacctgtt tccagttgtt cttaattgaa cagtggcacc aaactattgt 14880
cttgcctcat ccccctccca tggcctgtcc cccaaaaaga gacttcttgg gtaattaatc 14940
agggcaacat caggcagtct gggcgcggtg gctcacgcct gtaatcccag cactttggga 15000
ggccgaggcg ggcagatcat gaggttagga gattgagacc atcctggctt tgtgaaaccc 15060
cgtctctact aaaaatacaa aaaattagcc gggcgtggtg gcgggcgcct gtagtcccag 15120
ctactcgaga ggctgaggca ggggaatggc gtgaacccgg gaggtggagg ttgcagtgag 15180
ccgagatcgc accactgcac tctagcctgg gcgacagagc tagacttctt ctcaaaaaaa 15240
aaaaaaaaaa ggaatctctt tggttttata tatatttttt ttatatatat aatatatatt 15300
aaaatataat atatatattt atataatata atatataaat atattatata ttatatattt 15360
tatatattat atattatata tattatatat tatatattta tatatttata tattatatat 15420
atttatatat tatatattta tatatattat atatttatat ataatatata ttatatatta 15480
tatattatat attatatatt atatatttat atatattata tattatatat attatatatt 15540
atatatttat atattatata tttatatata ttatatatta tatattatat atttatatat 15600
tatatattta tatattatat atatttatat atattatata ttatatatta tatatgtata 15660
tattatatat gttatatatt atatatattt atatatataa tatattgtat atattatata 15720
tctaatatat tatatatatt atatatatta tatattataa tatatattat atattatata 15780
ttatatatat ttttatatat ataatatgta taatatataa tatatataaa aacatatata 15840
atatatatta tatattatat atatattata tatattatat atattaaata tattttatat 15900
atattatata tatatacaca tatatatata taaatgaggc caggctcggt ggctcacact 15960
tgtaatccca gcactgtggg aggatcactt gaagccagga gtctgagact agcctgggca 16020
acaaaacaag atcctgtctc tacaaaagga aactgtaaaa attagctggg catgatggca 16080
tgtgtctgta gccctagcta cttgggaggc cgaagcagga ggatcgcttg agcccaggag 16140
ttcaaggcta cagtgagcta tgattgtccc atagcactcc agcctgggta acacagcaag 16200
gccctgtctc taaacttttt ttttttaatt ctatttatat ttacatgtat ttaaatgtga 16260
atattcacta cctatttgtt gcatgcctgc attttttata ctgggcttgc caaaaacccg 16320
aacagctttc tactttgaca atgtatcaga atttaaatca gcaatatgtt aataagccaa 16380
gcaaaggtta tatatgcaaa taaaactgtt gtctataacc tcctgttaca ctggggcaca 16440
gcaaaagtca tggtgtagtc gcatgtgaac ctgtcccttt catagctgct cattgccagg 16500
aaacatcagg aatagccatt tggaagagtc atcagccctc ccaccatccg ttttctgtct 16560
tgtcttttcc ctatgagcag gggaaattcc acgctggccc caatccccag tgcagcggct 16620
cagcctctgc ctctgctgct ggtccccatg aggccagctt agaaacggag gattttgcag 16680
aacatcccta aatccgcttg aataatgaag tgatcattca taaactcacc tgaaccttat 16740
taaaacctat ttaatatttt tcctggataa tcctataggg ataacttgcc tcctgggctt 16800
ctctccaccg ggttcagttc ttcctttagt ggtgaagttc ctcccttctt agcatctcaa 16860
ctgtgcctga gaaaaggcca gtggcggctg cactctgttc cctgtggagt gttaataaag 16920
actgaataaa ttgaaataaa tccctttcaa tgtcattaag tgctataaat aatcatgaac 16980
caatgttcga tggctgatga gaaatgcaag aaaaaatttt taatcagtag gattcataag 17040
ttgacaatct gggccaagtt aaaaaaaata aaaataaaaa gacttttaaa aagatcttat 17100
cgtttgttac cagtaagact gaattccaga agcaagctac tccctcattt gtgggcccct 17160
gttatcactg gctgcttagg gttgccaagc cctgaattca tttgtcaact aagagatttt 17220
tggccaagat taagatttcc catgcctcca tatttccatc tgagaaatgg agattatact 17280
gtcttccccc tcagaatgga tgataatgtg gtctctcttc tgttcgcata gtcatagaac 17340
tgaaataaaa caacttaaga gaattccttt gagcttctca gaagtgctgc agggctgggg 17400
gatgcctccc aggagccgca gtcaggtgct gatctgaagt ctttggtggg ctgactttag 17460
cctgacctga aatagtatag ctgctgccac ctggctccct tagcgtcagt cagacggtgc 17520
agctggttcc taggggtgag ggctgagcca gcagggtccg tgcccaggag ggatgcatgg 17580
gtggccacag cccagcctgc actgatcttg tctgtcccct tctttggaag gaaggagccc 17640
caaaccaggg tgcaagacag tgggtggggg tgccttgagc atgacctcaa gtgatttcca 17700
gcccctgcca gtgctgactt ctctggggaa gggctgggac ttccttctgg gctcaagtca 17760
cgacccttgg atggaatttc ctgggagctt ttctgttttt tctggagttt tcagtttttt 17820
cctaaccaga cagggacttg gtacagaatc tcatattcta attatgccta ggagcagcct 17880
ctccccacca ctcacagtgt ttagcatgtg acaggaatcg attaaggcat gagtgattaa 17940
attaaagcca ggcattgact tggatggtgt aatattctga catctgtttg gtgtcaaagg 18000
cacggggcag gcgcgttaat tgaactgctt gcacctggca tttgaattga gccagagcgg 18060
ggctaaagtc agtttgcctt caccctgtaa atggagggtt tctccggagc gtggatggtg 18120
ggaggtattt cagggtgtat gcataacccc caccctgaca atggcccatc tcttctccag 18180
cgtggccagg tttgagtgcc agtcctgggt gtccagtggc cccatagcct tgcgttttag 18240
taaaatgctg cccccattac cacctggtct gtgcacttcg gtcactggaa tttgccatct 18300
tccagtcccg aatgtggcaa gccatggagc cttaagctct tctccctcca catcctggaa 18360
cagacccgcc agtttcttcc aggcattgcc tcagtttgcc cctctgtttc cagtcacact 18420
ctcaccagcg ataaaatgat tttagacctt atcatctcac cctcggatcc ttatggaaac 18480
aataatgagt tgttccctgt ttcaattcca aaattcatat ccaatccgtt ttgcatgcca 18540
ttgccaaatt cctcccagag caaccccgtc acctgccctg gccctctcca agtgtggtcc 18600
tgccatgggc atcgcctgct aagccaagct ggcctcgagc tgcctgcccg ggtccccaca 18660
ccttggctca cctccctgcc cagtcccgcc tcctgccagc ctgccctgtg gctccttcat 18720
agatgccgtg ctctttctgc cccttgctca cccatggcag ccttgcccct ctctccctgc 18780
cccaccccct atttaaattg acctgacctt cctcagtgtc catcttcccc gaagctttcc 18840
ccagccttgg cactcaaggt ccagaggcta cgcgtttcct ctcacctgtg gcagcgccgt 18900
gctccccagt gcctcacagt ttccttcttg cccccgcttc ctgtgtagga ctcatctgcc 18960
cacaggttgc acgtcctgtg agggcaagga ctgtgtctta tgtgactttc cttctccagt 19020
cacagagctg ggcacataga tagctcaaaa ccctctttat taacacagtt ggatgttgag 19080
aaatcaaaca ggccaatgtc aaatgagctc tccttattta aatcaagtca gttctccacc 19140
tcctagcact cagttccagt actctatata catggaaata ataaaaaaca catttccttt 19200
gaaacattct ataatcgttc ctttgcccta cttcagacca acttaacgca ctccccattg 19260
gtccaaatga gttttgctat acgaagatgc tgataataat agcagcagtg gattattctg 19320
ctaaaaccat tgcctcgtta atcctcagtc ccgaggtggg gattattatc ctcattttgc 19380
agagaagcaa actgagactc agagatttca cagctgggga gggagccagc tcatccctct 19440
gtccaggccc aagctctctc ccgcttgcct tcctgcctct gcaacctcag agcatccccc 19500
atctggttct actgcctgtg ctagtcgtgc aggagccaaa agacacgtct ttagtgctaa 19560
ggactggaga agccatgccc tccagcctct gtgaatgggt catatgtaac atgagcctgg 19620
agaaattatt tgaaaccaaa ggcaagcctc taaaccaggc tgctgcttca tggcgccggt 19680
gacggcagaa ccaaatttag tgctgtgggc aggtccacac ttatcaaata gagaagctca 19740
tttttcttcc ggctcacatc aagcatgaaa aatgttcaca catacccccc acacacacat 19800
gctttccgga ggggtccatg tggctagagg ctggaagatg tggatgagag gagcctggca 19860
ggtaagccca gggaagatga cattcagctt cccagacagc atctacaggg agaaatttaa 19920
ttaaaagtgg ggcggtttcc ctgagcaagg cagacaaagt cagccctcta ctgttaagaa 19980
aaagggtcac agtgagaggg gaggtgagga gactgagtct gtattttcta gtctgttggg 20040
ctacactacc tgatccccct tcctcaaaaa tccactttac tttccccatg tctacaccaa 20100
tgtggttcac actctgggac caggaaaagg gggagtgatg gggaacagag aagggaggag 20160
ctcacacagc tgaggctggg gttatgcata tcgaattact tagaatttgc aacctcacag 20220
ggtactttca tggcgttgaa atacacttcc cacagccacc ctccctctaa ctaaaagcaa 20280
gagtcatttc tcagttctgg tcttgcctcc cacgttctcc tccacattta agaaaatcca 20340
ccagctacaa agtgaagata ccatatgtga tatcccaccc tagtttctgt tttatcaggg 20400
tttggagcag gtggagcagg cagagggatc atttcagcct ataaattgta ttaagggtga 20460
gtactgagtc attcttcaag aaaagtttta gaagcatcca aaactgaagg gtggagccac 20520
ctggagacag tatcatcagt cctggccccg agcatggcct gcataggccc ccatggatcc 20580
cagcgggagc tgcagagtgc gggcaccttg gcacacagcc ctgagtgcaa aattaggagc 20640
tgggcagagg gcatctctct gtcgccattg ggcagcccag ggcacactgg tcatagcctt 20700
agaccacgaa caccctgtgc ccgggggaca gatgcaacca gtgtgccctg ggctgcccaa 20760
tggcaacaga gagatcgaca cctggacccc atgtcacggg gactccacta ctaaggctcc 20820
taagactgcc accttccagt gggataagcc ctgcctccta ctgggcccac aatgtgcaga 20880
gaacacttgg gactacctgg ctttctggat acacaaatat tgatccaatc tggactaatt 20940
agaaggtcag tcccaataac aaatcgaagt cagctgggcg tgatggctca ctcctataat 21000
cccagcactt tgggaggctg aggtgggcag atcatttgaa gccagaagtt caagaccagc 21060
ctgggcaaca tagcaaaacc ctgtctctac taaaaataca aataattagg ctgggtgtgg 21120
tggctcatgc ctgtaatccc aacagtttgg gaggctgagg caggtggtca cctgaggtca 21180
ggagtttgag accagcctgg ccaacagggt gaaaccccgt gtctactaaa aacataaaaa 21240
ttagccaagc atgatggcat gtgcctataa tcctggctac tagggaggct gagacaggag 21300
agaatcgctt gaatccagga ggtggttgca gtgagctgag atggtgccac tgcactccag 21360
cctggttgac agagcaagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa aagccatgcc 21420
tggtggagca ctacgtgtaa tctcagctat ttgggaggct gaggcacgag aatcacttga 21480
acctgggagg cagtggttgc agtgagctga gatcgcgcca ctgcactcca gcctgggcga 21540
cagagtgagt gagactccat ttcaaaaaaa taataaatct gagtcacttt aatattgtta 21600
tttggatgtc aacctctagg tgtttgagac aggagagtga tatgggggca ctggaaacac 21660
acaggcacgg ggtgtcctca cacttgggta gcccacacga tgtgatttca gggtgctggg 21720
aggtcccccc actccccaaa ttactaacaa gtggatagta ctttacagtt tatatgatct 21780
catttgattc ttaacatgag cctgtgagtg aaaaattcct tcccctcttc tacagattag 21840
gacgttgaga ttcagggagg ttcagaggga ttcagggaag tcaagtggca cctggagtcc 21900
cgtggctaat ttgaggccgg taggggattc gaacccagga tttgtgcttc ttatgcctgg 21960
gcttctgctc cctggggcat ggtcttcccc ctagctttcc cattcactgc tttagcctag 22020
gggtcctacc ctttattaaa ctgccagtgc ctcactgctt ttctccccca aagacaaaaa 22080
aaaagtgttt ttgcttttgt tttgtttttc atgggcagag acctggaatt tcagcttgag 22140
aatttgtgcc atatgataaa taaatcaaca gatggctttt tccttaaaaa aaaaaaaaaa 22200
aaaaactaag atgtatttgc agtgaggcat aatttgtacc aaaaagtgct caccacactg 22260
tagtcatggg ggcaggaggc agccgcgggt gaagggagaa atcttggagt ccaggcagcc 22320
cccttctggg ctgaactggg gagctggggg tgctgccagc cctgccaggt tctcctagga 22380
ggcggcagct catatggctg tgggaggagg cagagggagc ctcatatgca cccacatttc 22440
cagggatcta gaagacagaa ggaggaaaac caccatcatg ttaaagcaga cagttaggta 22500
acacatcctg taatacaagt tattttttcc acatctaaag gctaaaaata gttgttagaa 22560
tttaaagata attggtaaat gagtttctat ccttctagtt tcacatcaaa tggaatcatg 22620
ctgccttcac atcactagtg cccgttattt gtgtttaatt tccacaatgt tgtctaattc 22680
cactctttgg gcttccccag ggatccagcc tccctcactc gcccatcgca gggagatgct 22740
ttattcatct ttgtgtcttc tgtgccgggc atagcgcatg gcacagaata agcactcagt 22800
aattgattca cgagtgaata aatggatgag tgggtgagtt caatattgac tacaaaaacc 22860
ctaaggccac actggtgagt ggctgcgcct gtagtcccag ctgctgggga atctgaggca 22920
ggaggatctc ttgagcccag gagtttgaaa ctagcctggg cgatatagcg agaacctgtc 22980
tcaaatgaca aaaacagggc caggtgcagt ggctcacgcc tggaatccca gcactttagg 23040
aggccaagat gggaggatca cttgaggcca ggagtccgag accagcctgg gcaacatagg 23100
gagaccctgt ctctacaaaa aattttttaa aaattagctg ggcatggcgg tgtgcgcttg 23160
tagtcccagc tactcaggag gctgaggcag gaggatcact tgagcccagg aaattgaggc 23220
tgcagcgagc catgatggca ccactgcact gcagcctggg cgtcagaacg agacctgctc 23280
tcaaaaaaac aaacaaacaa caaaaaaaaa ggctttctta aagagacttg agaacagaaa 23340
ggggaacaga tacataactt atatatttat ttgttcatct ttccaccttc ctggagggtg 23400
gaggggaaca ggtctgtatt tggagttttg aatgctaaaa gtgggaatac atgtactgtt 23460
tgccatgatc tgttcaaaag ttaagccaaa tgccttagat tctcctgaaa actggaatgc 23520
cactgtaaac tataagcccc acttcaaaga taaaagatct tgatgaacag ggctgggtct 23580
gtggactggg cctctcccca ccacacaagg aagggtggtg ccagttgaag gaaaatcact 23640
taaatccttg ctgtctccta ataaggtgtg gtcccaggta gggctgtcag aattagcaaa 23700
ttaaaacaca gggcatctgt gaaaattaga atttcagata acaacaaata attggcatag 23760
gctgcataat gtccctcaaa gatatcaggt cctaatctcc agaacctgta aatgtgatct 23820
tatttggaaa aggggtcttt gtagatgtgg ttaaattaag gattttgaga tggggggatt 23880
atcctgtatt atctaggtag gtcctaaatg cagtcacact catccttgta agaggaagga 23940
agagagagat ggaaaacaca gaagagaaga caatgtggtg atggaggcag agattggagt 24000
gaggtggcca caagccaagg actgctggca gctaccagca gccagaaaag tccaggaacc 24060
aattctctct tggagctcca gagggagtgt ggccctgctg acaccttagc ttcaacctag 24120
tgatcctgat tttggacttt ggccttcaga agtgtgaggg aatgaatatc tgttgtttta 24180
agccaccaag tttatggtca tttcctacag cagccacagg aatcaaaaac agtaagtatg 24240
tcccatgcaa tgtttgtgac acacaccaaa aatattactt gttgttcacc tgaaattcaa 24300
atttaactgg gtctcctgta ttttatttgg ccaacctagt tcccaggccc aaagaaagag 24360
gcttttgaaa tttgcaagaa agctggttgg agctgtcaga aagtggactt tgtaaacaca 24420
gtaccaccga accaatttga actgtactac ctctagacaa aagagagggc agtcagacag 24480
ttgttcgtga tttcttcttt caacagtcat ttgagcactt actacaaaac agaagctatg 24540
tgtaagggtg gaggcgttag ctgttaatca ggacctccag gctaagtttc tgtattagtc 24600
cgttttcacg ctgctgataa agacataccc gagactgggg aatttacaaa agaaagaggt 24660
ttaattggac ttacagttcc aagtggctgg ggaagcctca caatcatggc agaaggcaag 24720
gaggagcaag ccacatctta catggatggc agcagacaga cagggagaga gagcttgtgc 24780
aggggaactc ctctttttaa aaccatcaga tctcgttaga cttattcact atcaagagaa 24840
cagcacagaa aagacctgcc cccatgattc agttacttcc caccagatcc ctcccacaac 24900
atgtgggaat tcaagatgag atttgttacc atatcagtta ccaacccttc cagataaatc 24960
acgtgaaata tcgccattaa cagagtgagc tcaggtggtt cttcagtgca tttctgatac 25020
ctgaaccttc cctgggaatt tcacagacca tcaggctctc caccctttga tagcaggata 25080
gcagggccca ggttctgcag gaggagatgt taccacaggc ctgaaaggga gggaggggca 25140
gatgctacag gaagatgctg gctctggatt cgctggagga gctttcaagg gaagtagata 25200
cacactgtct ccatcatttc atgtccatca cactctaaaa tgctttggac aagaagcaaa 25260
tgttaaagac aaatgtggcc cattttcctg tacaaagagg gctgctccca tgccaggcta 25320
ttggcactgg tgggcatgag gcttctctgc tgccctggcc ggggggttct ctcactcacc 25380
attggctctc tgacacctgg agagaccacc acccttgggc tttcatgatg ctcacagaat 25440
ccacactgtt ggagctttaa ggagcctgga tcaactggaa caggcaggga gtactaggac 25500
agcccagcat tgccccaaaa tatccaggcc tgataaaaga gaaaaacagg tagctcacag 25560
gaaaaggata aaaaaaggag gagggattta acatgaaaag gtgcttgatc tccctcataa 25620
taaaaagact gctgattcca tccaggcaag tgacagaaaa aaaaaaatta atttaaaaag 25680
actgctgata aaaccacagc gagacactgc tgctcaggga tctgagggtg tgggcagcca 25740
ggctgccacg catcatgggt cggagaggaa gaccacaccc ctggagcaga gggcggctga 25800
tctgtcagat gccctttgac agcacctcag cttccaagaa ttaacccttt ctatgtgagc 25860
agaggcatcc atggggggac acactggtga atcatctgtt atgtagaagt ctggaaaaca 25920
tcaggatgga actggtgaaa taagtgtggc ctctgacgga atggagcggt ccgtctgcac 25980
tgctgcgggt gcccctcaga tcctgtgggt cagtgagaaa agcagtgagg aacaaggcag 26040
gtactgtgta ctgtcctctg cgtgcaagga aggccagcgc atgcaacaga gtccacacag 26100
acatagccta actctggaag gaagaatgag aatgcagttt cagtggtggc ctctggtggg 26160
gagaaactgg gtgaagggag atgtcatttc catttctcta ctattaattt tgtattacca 26220
tgcttaaatg ttacttttta cctttttttt tttttttgag acagggtctc tctctgttgc 26280
ccaggcagga gtgcagtggt acaatcatgg ttcactgcag cctgaacctc ccaggctcaa 26340
gcaatcctcc cacctcagcc tcctgagtag ctgggactat aggcacgcat accaccgtgc 26400
ccagctattt tttttaatca agatggagtt tttctatgtt gcccaggctg gtctcaagct 26460
cctggactca agcaatcctc ctgcctcagc ctcccaaagg gctgagatta aaacgtgagt 26520
caccctgccc agccaattgc tttttaaaaa agattaaatg catgtatacg ctcaggcatc 26580
agcacacttg gaaaggatga aaatatccgg aagaagggtt cttttaaaag gctcctcaag 26640
tgatgctggc aggcatgacg aatgtccctg gtcacaaaag ctctgatctg gcctaaccct 26700
gtcatgttag agactggagt gcgtgtgtgt gcgcgcaaag tgtgggggga tgggggtgag 26760
tgtgtgtggt gtgtaagcat gagtgtgtat gtgtgtggtg tgggggtgtg tgctgtgtga 26820
gcgtgtgtga gtctgtgtgt gtagtgtgtg tgtgaagtat gtggtgtgta tgtgtgacgt 26880
gaggtgtgtg tggtgtgtga gttgtgtatg gtgtgtgcat gagcatgtgt gtgggcatgt 26940
gatgtgtgtg tggtgtgtaa gcatgtgtga gtgtgtatgt ttgagcatgt gtggtgtgtt 27000
gtgatatgtg tgtggtgtgt gagcatgtgt gtgtgatgtg tctgtgtgtg gtgtgtgtga 27060
gcatgtgtgt tgtgtgtgtg gtgcatgtgt gtggcgtgtg agcgtgtgtg tgcattgtgt 27120
ctgtgagcat gtgtgagtgt gtgtgtgttc agcatatata aggcatgtaa ctgaacacag 27180
cactttagag ggctctcctg gagtcagagg gggtgggtag gaggagaagg gaggtgggct 27240
agtgtgctga agtatctact ccttgtcata gtctgtgaca acccagacta gcccatgagc 27300
caccctgttc cctgcatttc caatgagacc tcggtggaca tgttccctga ggtgaggctg 27360
actgatgtca tttgacgatc ttgatgccaa atccttttat atcaaaaaca accagaacac 27420
tctcttttct cttagtgctt tcacccagat gaccacattt catcctccca gccactctgg 27480
gccaggtggc actgctggtt tgaaagggag gtctcccctg gagtaacttc cgtgggcgga 27540
ttcacaccct gcccacagtc ctgtcccagt cagcccacca tggtggtctc cggttcctcc 27600
agaattcccg cttttcagct catccccaca ttcccggagg gactgagagc gcagccccag 27660
ggccctgctc tttgggggcc gtctctacac ccagagaagc agcaaggcat tcctaggttt 27720
ctctttcaga tgcagaactt cagtgttcag agatgttccc actggtcctg agagggctca 27780
gttcagcttt aatgactgcg ctgttgcgtg tgctctgcag agggcgggtg gcccagcgtg 27840
gctgactgca gttttcctga cgtggagccc gagcctgccc cgctgtttat taattaagga 27900
tcactctgct tgcagaaccc tgaactcccc agaactgtga ggtgggagaa ccccgagagg 27960
ccacctggcc ccacttccca cctgctgccc aaaccccctc tctgccttcc tgacagtcac 28020
cccaactccc agtgatcccc atcaaccatc tgacaagggg actgagaggg aagagaaagg 28080
aggggcccaa agaggaaggt aaaactgtcg ggaacagccc ccaaatgtgt gacagccttc 28140
agtggagttg cccactttcc cttttctcct ccctgcagga cctcccttct ccccagtcct 28200
ccccaacttc tgaggttaca ttgagaaaag tctgcagaga ggtgccagca tcacaaggtg 28260
ttaaggacca cgagtttggc attttaacag atgccagagc cacttgagaa atgtggtaac 28320
taagcccaga gaggtacagt taacctcccc agagtcacac agcaggttca tggcaaagct 28380
ggactagcac aggtgtcctt cccctgcaga tccccttctg tgccccacat cacctccctc 28440
cagtgtctgg gccacctgga gatgggccct cagactcacc cggccagagg tgccatctca 28500
tgggagaggt ctggccagga agcatcgata tttgagatcc caagaaatga agacttggcc 28560
tgtcagatga cagacttcgg tcatgggaac acgtgatctg ttttacacat gcgtcccctc 28620
agcagcagct ttccagaaca ttcccacttt cttctgtagt gagaagaact ctttccctgc 28680
agcctcctgc ccaactcctc cttcagtgtc tttgcttcag tgtctttgat aaaccattct 28740
gctttgcaga gtgcgagctc tgccttgcag ggttcgcatc tgcctgtgct gagtaaccaa 28800
cgctaaggtc gagtggtcgg tcacctctca taagagctag ggttgtctca tgctgatgac 28860
taggacttgc cctcaaggag aaaaataaat caaaacaaaa gcaaaaacag caaacatgca 28920
tctcttaaag aaggctctga gtccaggtaa atttccttcc actgaagcag ccaggctgaa 28980
ttcgaattat ctttgcccct gcttaaaaac taatgcaaat tttcctagag aatatccact 29040
aattcctgga gggggcatgg gcattcctga tgcccatgag aggaccattt gctcttccct 29100
cagtatgcta aataacagaa gcgacatttg ttgctggaaa gtatcagtga agttaataag 29160
gtttttcttg cccagggtga gggaacagtt cccaatgaca aatgctgtat gggaaggggc 29220
tgtagaactg ccagcccctt tggtccatcc gtaaagtgaa ctctgtggat cctggaggat 29280
tccagcgtct tttttttttt ttcttttttt ttaagacaga gccttgctgt cacccaggct 29340
ggagtgcagt ggcacgatct cagttcactg caacctccgc ctcccgggtt caagcgattc 29400
tcatgtctcg gcctcccgag cagcaagact acaggtgcgc accaccatgc ccgactaatt 29460
tttgtattat tagtagagac gggggtttca ctctgttggc caggctggtc tcaaactcct 29520
gacctcaggt gatccacccg cctcagcctc ccaaagtgct gggattacag gcatgagcca 29580
ccatgcccag ccagcatctt tcatttttct gtctgctttg gccctttcct ctctcactgt 29640
cttccttttc catttccaaa gtcagtccat ctcactatta gcacaaaaac tgctagagcg 29700
cttgtcattg gtcatctctc cctgcacctg gctggtctgt tcttggccac tgaagcgttt 29760
cccccagctg ttgctttaat cattttattg ttattatgcc ttacttaaga aatggatatg 29820
agatgcattt acctgtctct tcctgccact ctgcagagcc agtaagatgt ggtggaaagg 29880
gcccaggctt tggaggaggg ctggctgggg ttggatcttg gctgccccct actagctgtg 29940
tgaccttggg taagtagctg gacctctctg agcctggttc ggaatcatag cacctctctt 30000
tcagggctgc tgtaaggaat agcagtggtg tgtataaagc agagcgcaca gccagcaact 30060
ggcccctagc cacactgctg agcacctact gtgataagct gccattgtgg tgtgtgaagc 30120
aaaggggaaa catgcctgct gtagtgagct tcctgtaggg caggttgtag aaccagaggt 30180
gggttccaag gttacaaagg gactcttagt gtattagtct gttctcacat tactataaag 30240
acctacctga gactggatca tttataaaga aaagaggttt aattggctca cattggctgg 30300
gtgcggtggc tcacgcctgt aatcccagca ttttgggagg ccaaggccgg cggatcactt 30360
gaggtcagga atttgagacc agcctggcca acatggtgaa accctgtctc ttctaaaata 30420
aaatacaaaa attagctggc catggtggtg tgcgcctgga atcccagcta ctcaggaggc 30480
tgaggtggaa gaattgcttg agcccgggag gtggaggttg cagtgagcca agatcgcccc 30540
actgcactct agcctgggca gcagactgag actctgtctc aataaaaaaa aaaaaaaaga 30600
aaagaaaaag aattgcaaga aataaattat tgtttatgag ctatatggtc tgtggtacct 30660
tgttgtggga ctgggagtct tggcgtctcc ctgaccctgc ctgttgctgc agcaccgctc 30720
agccctgcct gctccctacc tgcctcccct cggcctctcc tgcctccacc gggcccctgg 30780
tgcctcctct agagacagtc ctcctgggac cgattgtgtt ctcacttaca cgaggcatcc 30840
aggactacag ataaccagag gaaggggcgc cccccccgcc tgccctcctc cctggcatcc 30900
tcacgctgca gaggtcagag cctcatccca gccccttacc tgcccctact ctgtggagaa 30960
ccgtggtcag ttcgccaggc cggatccacg aacggccttg tggaagatgg tgagctcaca 31020
cccagagctg gctccgatga ccctgtctcc tttacatgtt tctaccttcc cctccctacc 31080
ttcccccact gctgggcgca gagtggaggc agatgaggtt taaagctcag aagggcttaa 31140
acgggttggg gcgcagtggc tcatgcctgt aatcccggca ctttgggagg ccaaggcaga 31200
ggatcacttg agcccaggag ttcgagacca acctgagcaa catagtgaga ccgcgtctct 31260
acaaaaaata aaataaataa aattagcttt gcagggtggc atgcacctgc agtccctgct 31320
actcagaagg ctgaggtggg aggatcgctt gtgcccagga gtttgaggct gcagtgagct 31380
atgctggcac cacagcactc cagcctgagt aacagaatga gatcctgtct caaaacaaac 31440
aaacaaacaa acaaaagaag gcttaaaggg ggctccaggt gggcttggca gcacaaagct 31500
atgaagttct atcttagaca caagttctgt tactgggcct ttgcaggctg gcctgggtac 31560
ctggctgcca tagacaggga accttccaga tgagctgcag gcgtggagca caggagccag 31620
ggtgctcttc ctgggctctg tccacaggca gaacgtacac agtctttgta cacgtccggc 31680
ggctctggtg cctatttttg tttgtgtttt tcttttgttt ggggggatgg atttggtttc 31740
ccccgagccc tctgtcctcc tgtcacctgg ctggtgctcg gcaatgttga ccagctgcct 31800
ggctggagtt ggcagtggct aaggctgtga cagctaacat gttcctgagt cctctcattt 31860
cttcaccata atgccctgtt gagtttgcag atactgtctc tgtttttatc tcccggggaa 31920
actgaggctc agagtggcta ggccaccttc ccatggtccc tcagctcatg agggccacac 31980
agggcattgc ggtggccttc tcctcagcct tgaccctccg gccccagcat tgctgcctca 32040
aggggtctcc tctgctgagc cgtgcacctt ctgcctggca gctccaactc tgtggctgtg 32100
ttcagtggct cagcactgcc ccttgaccct ccctggcctt ctgcggatgc cagactggag 32160
cactctgaca aggtctgggg tggttgtatg ggtcctgtga cctctataca cctcccagtg 32220
cctgggaatc ctgcagatac accctcctta gccgtcccta accatagagg acatttctga 32280
ggtccccgag agagtggggc acccctgcag gatccaactg ctgggcccag gaaggatagc 32340
agcagcatga ggggttccat tagccacaaa ctcacggcat ggaaccttca cccacctcgc 32400
ccctcatctg ctgtttagca cctggcacgc cgtgtatact tactgattat tacattttaa 32460
tggcaaatta tagtggcaaa cgtatgcatc tttgcacaat tgttgtacag catgatgaac 32520
aagtcattaa tagtaaagaa taaatgtgaa agtgagaaaa atctgactgc caaagttttt 32580
actccttcct tccctcccca gacttttaaa tgaaagttta gggataatcc cttagttgtc 32640
ctgctagtag gacttgcaat taaaagaatt gggccaagaa cacttctacg cttctccttt 32700
taggtttggg tgtaaattcg gggtatttct cactgatgaa agcctggtgc agggcagacc 32760
gtgggaagct ttcatttccg gaatggacca tcaacatccc ttggagaaga attctcttct 32820
ccagacccag acctggtgtc ctggcaccca ttgggcaagt gggtcctaga agacaaacct 32880
ggtcagagcc tggaggctgc ttagcattcc ccacgcacat tagcagctcg gagagctcag 32940
gaagccgcag cccctccttg cctcaccagc ctggatcagg acagcatccc ctggaagaca 33000
cacagggcct ggcctctgat tacccagcct ggagggaaag ctcaatcgag catcatgtca 33060
cccggtgccc ccatgcaggg tggcactggt gagaccccca agccaatgat accacctcac 33120
aggagtgcag gcccattgtg gccagatcat cttgactttt caagataaat cagaaatcgt 33180
atttccatga gatatcccta tttgcaagtg atggtgacta aattagaagt ttttgaatat 33240
tgtaacatgt tcgtaggctg tttgtctggt ttaaactcta tctggaggaa ttcaagctag 33300
acttcaggaa taacttcttg aggcaaggat tttgagacct tagggaaaga aggacgtctt 33360
gggggtattc tgactgttgt cctcctggaa gggaagaaca gagaactaga agactgccct 33420
tagcgaagtt caaagcacct aagcccggga ccctcagcaa gtgttcttga gtcacagatt 33480
ctccctgagg cgcctctttc tggctccata gaatggctga ttctgtaact cggtgagttt 33540
gctttttttt tttcctccat cacccaggct ggagtgcagt gaagctggag tgccgtggag 33600
cgatcactgc aacctctgtc tcccaggttc aagcaattct ccttcctcag cctcccaagt 33660
agctgggatt acaagcatgc agcaccacac ctggctaatt tttgtgtttt taatagagac 33720
ggcccgaagt gctaggatta caggcatgag ccaccgcggc cagccataac tctgtgactc 33780
ttgttacaaa ggccttatat tttgctcttt gagggtggtt ttggtttgat gcctgttggt 33840
tgccatcttt taactaggga tgttttatca aaatgcccag ccaaagtgtc caaacaaatt 33900
ataccttaaa gtttgaaaat gtctggcact tctaattcaa tgcctgttgt gccaggcact 33960
gggctgctga ggaactgagt cccgtccctg caggctagct agagaacaca cacacacaca 34020
cacacacaca cacacacaga gtggtcttac aagtcagttt tatattctac ctatatgcaa 34080
taaaggtatt attatgttga ggtgccttga tataaaaatt tttcttaaag gagaggatgc 34140
ctaaaacagg cattacctga aacctcctct ctccagcatt ggttgtcttc tgtcatgact 34200
cagggttttc actgagaatg ggatggaaat gtggtctaaa gatagggcca atgttgggac 34260
tggatcccct ctgggaagtc agaccaggct agggcaggtc cttgaagcca tcaggaaaag 34320
cctctggagc cagaaacaaa acaaaaaaaa aatggtgtta actaaactca gtctcaaatc 34380
ctgaatagga ctcaagtcaa gcaaaataat taaaggagtt agcaaagggc aagtcagaga 34440
gaccgagcaa caccaatgtc ttccgggagc cctgtggcga gtgacagagc ctggactctg 34500
gagtagaact catcttgtgt cttcttctgc cactcgttag ctgggtgacc ttgagccaag 34560
ccccttaacc tcttggaccc tatgttctta tctctaagta ggggctggta atatcttccc 34620
ctttgaggaa tgccctctaa ggggtgttgt gaagattcgg taaggtggca ggggtaggac 34680
tcctggccag aaacaggcac ataataaatg ctaagtctct ccttctctcc acctgctgga 34740
tgctgtagat actaaggatt tcgatgtgaa tgagacaaaa cccctgcctt ccaggagcct 34800
ttgagaatca gagaactaga cccatttcca gaacaagggg atgcagggtc tggataaagt 34860
tttggggatc aatagagcag agggctccca gaggatccca tagggttgac tcctaactca 34920
agggcatgag acaaccccca ggaagggcac cctggaaggg gtccggctgt ccctgattta 34980
cttgtgggca ctgggggaat gcccggagcc atccagccct cagggctctg tgtgattctg 35040
ggttcctccc ataaaagata atcagattct ttcacgttaa tgtctttctc cacctcattg 35100
cacatcatgc agctattcat tgactcagca agtatcagct ttgcatgcga ccttggccta 35160
cccactttag cttttagtaa tagctccctt cttgaataat acaaccagtg gggaaacaga 35220
acctaactct tacctctggg aggcttattt gctttgagaa catatgtcct gcagttttgt 35280
tcatatggca gtgaagtttc gtgcacacac tctagagcca ggcagcctgg gttcaaagcg 35340
cagctctgcc aggtcctaac tgcatgaatt tgggcaagtc gctcaacctc tccatgcctg 35400
agtttcctca tctgtaagat tggagcaatg gtaatacctg ctttttaggg ttgagaagag 35460
aattaaatga attaagatgg gtaaagtgct tagagtggag ctttgcaagt agtaagtgct 35520
atgtaagtgt tcgatttaaa atgaaagacc cttaaataca ttctttgttc atttcacaag 35580
cccttcattt cacaacctta catttcacaa ccaagctctg tctcccctgg aatccagcca 35640
taactctgct cacaagtgtg agacaggccc cagcagagct gcacgaagag gagagaaggc 35700
agccccccag actcccaacc ccctgtccaa gatggcaaaa ccagaacaca gcctctgtac 35760
caccccagca ggtattcaga atctgcaatc tccaaagccc acttcaattg taaatgtaga 35820
gccacgtgcg ctttaagtca cctgtcactc tggaggctct tttgctcagt tcctcaccat 35880
tagcagggat gacagggagt gcaggagtgc ggtcgactcc cagatattgg agagcgctgg 35940
gctagctgcc cattctcccg gcctccactc ctctttgctg tccagccatc acttgctctt 36000
tgaaggcaaa caaaacagaa aacagtgcca aaagtatggg aagaaagcca gcttctcccc 36060
tggggtgcct gtgatgccat gcccaccctc cctgaccacg cagcccctgt ggaccctcag 36120
ggccccaagc ccccatttcc atcacatgcg tacacccatg tgtgtccata gccgcccatc 36180
tcagtcaata aggctgctcc tgcccacttg gaatagtggt gacaaccagg agtggcttat 36240
gggaactatc ccaatggcct gacagcatgt ccgctgcaaa ccgctgaggt aggacactgc 36300
cctcatgtct agctgatcag caagaggcgc agttgctttc ttaggtaaca ttgctgctgt 36360
gtcctggcca ttgctggggg gtggcactta atctacacca gaattttccc tcctgtatct 36420
tccaagctgc ttggatcttg gtgctgaatt aggttggact ttgtcttgtg gggaagggag 36480
gactatagac cctcaacgta agcaatggtc agactattct aagaaaactc gccgaattaa 36540
agcatgaggt aaatttagtt ctgacttctg tccaccccac tgccactgtc cccttttatc 36600
ccatgatccc ttgcttttct tttcctcctc tctccctatc tcttgtgttt gacgcatgat 36660
aggaattcag aaatatatgt ttgtggattt gtttattcac gtagcaaacc atttcttgag 36720
tgcctaccat gggccaggta gaatgggcgg ccccgggctg cagtggtttc ttcagcccct 36780
ctccagggtt tacactgtgc aagacggttt gtgatgggtc ctcccatcga ggaccacact 36840
cttctttctc tgtgcccctt ggtcctcagt ctctgacccc acttcaaagg cagcattcac 36900
tcagggaagc tcccatacaa tgctagtcag agtaaaagtt tggacaaatt gccaggaagc 36960
agcttgtcag tatgcataaa cagcctttaa aatattacta ctctttgacc cagaatttca 37020
cttctaggaa tctgtcctaa ggaagtagtc acatgcaaaa gatttatgta ccaagatgtt 37080
catcaaagtg ttgttttata acaggaagtc tcagaagctg gataaatatc caacctctgg 37140
aaatggttag atagaatagt atgtagccat tagaaaatta tgtctatggg gtttaaaatg 37200
tcatgggaaa acacttctga cataaaagag catgagaact gtatatttag cataatctta 37260
actatgtttt agaatgcaca ggaaaaaaat gtacaaacat attcatagtg atgtctctgg 37320
tggtaggatt atgatcagta agtacttctg tctcttcata ttttcctgta tttgataata 37380
catgcatatg ttgtttttaa aataagaaaa attttaagtt taaaattgga gctgaaaagt 37440
gtttttaggt caggcgaggt ggctcacacc tgtaatagca ccactttggg aggctgaggc 37500
agtcagatca cttgagccca ggagttcgag accagcctgg ccaacatggt gaaaccccat 37560
ctctactaaa aataaaaaaa ttagccatgt gtggtggcac acatctgtaa tcccagctac 37620
ttgggaggct gaggcatgag aattgcttga acccaggagg tggaggttgc agtgagccaa 37680
gatcgtgcca ctgcactcta gtctgggcaa cagagtaaga ctctatgtca aagaaaaaaa 37740
aaaaagaaaa gcctttttaa acagtagcag acataactat ataatcctta ctaagctgtc 37800
ggtcaaattt ttatttatat atttatttta ttcatttatt atttttagac agggtctcac 37860
tctgttgccc aggctggagt acagtggcgt gatcatggct ctcttcaaac ttgacctccc 37920
gggctcaagt gatcctccca tcttagcctc ccaagtagat gggaccacag gtgcatacca 37980
ccacacctgg ctaatttttt ttatttttta tttttagaga tggtgtttac tatgttgccc 38040
aggctagtct caaactcctg ggctcaagct atcctcccac ctcggcctcc cgaagtgctg 38100
gggttaccag catgagccac tgtacccagc cctcaaattt ttaaaaatct ataagagaca 38160
ttattggaca attagagaaa ttcacatatg gacttataat agtatcagag tgtgtggtgt 38220
gatggttctg gagggaatgg actttttctt tggagacagg cttttctatg cccacccttt 38280
tatcttgcta acttatcatc atccaggttc cagcagaaac attacttccc ccaggaaatt 38340
tcttaagggt gcagtatcat gatgtctgca gcaaattctc aaatagctca ggaaaaaagt 38400
acgtgtgtgg tatgagtgtg tgtatgtatg tgtgtatata tatacacata tatacacata 38460
tatatacata tatgtgtata tatatacata tatgtgtata tatatacaca cacatacaca 38520
tatatataca cacacacata catacatgta tttttatata attatatatg cagagagtgc 38580
aaatgttgcc aagttaaaga ttggtgagtc taggtgaagg gaatatggta tttattgtat 38640
tatttgtgca acttttctta agtttgaaaa ttttcaaaac aaaaaattgg aggaagaagg 38700
catgccagtc taccccaagc cctccattgg aatgctgaaa atctaaacaa tgtgatttgg 38760
caatttcatt tcttttctgt tgtgggccag tagtccttag atgttgggga agggggtagt 38820
cgctgaggtg tggttgactt aggatggaag aagcagaagt caagactccc agggtcaaag 38880
tggtttgctc tgctgaccca agtgtgggag gcccagagtc agcgtttcag gtgtgctaat 38940
tcagcatggt tctattcacg gccaaagtcc accctgggca cctctctggc agcaatcttg 39000
ggtgactcta ctaaggccag gcctccatga ccctatgtct ggatcccata tctccacctc 39060
tcccactgtc tcaggaacgg tgcttagctt tttcttttcc ctctcctgtc ttctttgcca 39120
gcatgtagaa agtttaaata attcccctct ttacaacaaa acaaaacata cccccttcag 39180
tcaaccaccc tagctctctt ctccttttcc cagccagatt tttttaaaag catcctaggc 39240
caggcgcggt gactcacgcc tgtaattcca gcactttggg aggccaaggt gggtggatca 39300
caaggtcagg agatcgagac catcctggct aacatggtga aaccccatct ctactaaaaa 39360
tacaaaaaag tagccgggag tggtggcagg tgcctgtagt cccagctact cgggaggctg 39420
aggcaggaga atggcgtgaa cctggtaggc ggaggttgca gtgagccgag atggcgccac 39480
tgcactccag cctgggtgac agagtgagac tccgtctcag gaaaaaaaaa aaaaaaaaaa 39540
aaaaaagcat cctcagcact ttggcaactc catctcctcc caacatgtcc ctgttactgg 39600
aatccagcca ggactcagcc ccgatctttc tactctaacc agttgtctca gttaacaagg 39660
acaggtttat gctgcagtga caaacaagat cccaaattct tgtggcttca cacatctggc 39720
accacctcat cttccagcct taggagtcat cttttagttc cttgaaaact ctttacagtt 39780
ttctgttggg gccttgtcat atactattcc cctggaatgt tctttcctat cccctccctt 39840
tcaccttgct aacttgtgcc catccttcag gtctcagcag aaacatcact tccttgggga 39900
agttttctcc aacacccaca ctacacaggt gtcccatcta cactcctatg actttgtggt 39960
acttgtctca cttcattttc cactgccttc cccacaaggc acctgcacaa gggcaaggac 40020
cgtaccactg tacctatgtc actcattgct gtggtcacct gcactctggc tgcctacctt 40080
aactacacat tagaatcacc tgaggagctt ttaaagccac aatgcaagac tccaccctag 40140
gccaattgga tccaaatccc tggggtaggg ccagacatca gtggagttat atatacatat 40200
atatattttg tttgtttgtt tgtttgtttt ttgagacaga gttttgctct gtcacccagg 40260
ctggagtgca gtggcgcgat cttggctcac tgcaagctcc gcctctcggg ttcacaccat 40320
tctcctgcct cagcctcctg agtggctgga actacaagtg ctcgccacca cgcccagcta 40380
atttttttgt gtttttagta gagatggggt ttcaccgtgt tagccaggat ggtctcgatc 40440
tcctgacctc atgatctgcc tgcctcatca gcctcccaga gtgctgggat tacaggcatg 40500
agccactgca cccggccatc agtggatata tttttaaagc actgcagaga attctgttgc 40560
atcagcttga gaaccactga tctgccttgt gcttcacatt taaaactttt ttttaatgaa 40620
taaataaacc ccaaaaaatt aatctcccta agcctcccta gaagatagga tggtaaggat 40680
attttcctag gtaaaaatat gttaatttca tatttcatga aatttcatgt ttcatttcaa 40740
tcaagctctg tcatacacct tacatggggc aagcccagtg cctgggcagg gtgtaattat 40800
actcattaca caggcaagga aaagtcacat taggtgatgg agcacaaata ggcagttaat 40860
ggtttcaggg ctagttagga tatgtttgtc tttcaattgc aagtaataga agcccaaaga 40920
aattggttat ttatataata taattgattg gttcccaaat ttgaaaaatt caggaataga 40980
cccagcttag gtacagctgg atccagtcac tcaaacaatg tcacaaagaa ccctttgaca 41040
ggaatgtatc ctgtgttgac tctactttgc tctgagtagt ctttccccag gtgatgataa 41100
aaatggtcat catcgccagg cttgtgtcct gtttagtagg aatatacaag aagagctcag 41160
taaatgctgg ccccaccact aagcaaaaac aaaacttttg ttgttgttat tgttgtttta 41220
aataacagct tagacctttc ttctttcctt gttattctct ttcatctgta atccagtttt 41280
ctacttctga agtatagaat gttctgatga tttattcttc attacccaca acttgcacat 41340
gtttatttaa aaatgccagg attgcctggc cgttgtgtgc tgttaacctt tgtttgctgt 41400
tagtggatcc ctgaagttca ggctcccagg ggagcagata atgggtatcc agttcctgca 41460
atatccaccc tctggcaagc caagttcctt cctgggtaag gttttgccta cctgcattcc 41520
tagggaagtt tctgggcctg accaccaagc cagctctgag aaggggtgca taagccccac 41580
catgctttgg ctctgtccct atagaatatt ttatgttgtt actgaaaact aaaggaagat 41640
gggtgcggtg gctcatgcct gtaatcccag cactttggga ggccaagaca gattgatcac 41700
tcgatgccag gagttcaaga ccagcctggc caacatggtg aaaccttgtc tctacaaaaa 41760
caaaacaaaa caaaaattag ccgggtatgg tggcatgcac ctgtggtacc agctactcaa 41820
gaggctgagg cacaagaatc tcttgaacct gggaggtaga ggttgcagtg agccgagatc 41880
gcactactgc attccagcct gggtgacaga gcaagattct gtctccaaaa aaaaaaaaaa 41940
aaagaaaagg aaagctaaag gagagagact aaaatgatat caggttcctg gagaacaaac 42000
agacatgatt ttgcttcatg gcaggacagc cggaagaagt gggattatat cctcacatta 42060
caaataagaa aactgagact cagaatggtt aagtcacttg tcccaggcca cacagccagt 42120
aaattacaga aacagaattt gaacccaaat cttccagctc caaagcttgt gttcttttca 42180
ctacctcctg cttaattttt taatttctaa gattagaccc ttcatctatc catgacacct 42240
gcctgtcatc ccctgaaaaa aggtgaacgc cgttcagaaa tttttctagc ctgagctcac 42300
tcccagttca cttatttttg ctttgtcatg gctgcccagt ccccacttgt agaccaggaa 42360
taggtcatgg ctgcggggac tacacgctgt cgctgctgca agggccggcc tctgtttccg 42420
gggctgagtg ggggccagac ctgccaggag caccatcttc tgtgggtcct gcctggatgt 42480
cacatcccgg ccccaagaag tcactgcaaa ccttcgtatt attgagcttc acatcctaga 42540
atttgctgtc actgtggctg ctgcatgaag ttgtcctgag agaaacgggc attgtcatta 42600
acagggaaat tgatggtctg ggggaaaagt catcctcatt ctcttgcaga tctatgggtg 42660
attgagactg gctgatgttg aaggggtttc tcagccatcg tgtgccatgt tatggaacag 42720
tggtgtagcc agccatttga cacccagcgc tgacctttgt ttaacaacct cacctatata 42780
tgacaaaatg attgtcagaa ataatcgtgt aatgaaatga ctgtaataat ggccagaaaa 42840
gaaacgcaga tagtaaaatg tttctcttgt tgaactctgt acatataatt gcaccaggat 42900
ttttttcaaa taaaaagtaa atattatact acaaaaaagg gaaaaagcac aagcatttat 42960
taaatagctt tctatatctt tctgagtttt gatcctttga ttgcagactg atgtaatatt 43020
ttatgtaaat cattgcttgg ttactaagtg aactttaaga aaagtgagac gtctgcagaa 43080
gttgcccata atttagcagc tactgtattg taccattgat gtacggcttt attttcttga 43140
ttaattattt aaacaatata attcacaatt ttaaaataat aaatttccac ttaaaatggt 43200
atttaaactc agcaaaatat atcatctatg agtaaaattt gtatttacca agcaaaaata 43260
ttacagtttg tggttcacat gctgtctcac tgttttaaat tttaaataca aaaactccaa 43320
gtaggctggg tgtggtggct cacacctgta atcccagtac tttgggaggc tgaggcaggc 43380
atatcgcttg agttcaggag ttcaagattt gcctgggcaa catagtgaga tcctgtctct 43440
actgaaaaca attagctggg tgtggtggca catgcctgcg gtcccagcta ctcaggaggc 43500
tgagatagga ggatcacttg aaccctgggg gacagaggtt gcagtgaggc aagattgcac 43560
cactgcactc cagcctgggt gacagattga gaccctgtct caaaaaaaga aaaaaaaaaa 43620
agaaacacaa aaactccagg tggtcgcaca gaatgacagg actgaagtaa cttagctcca 43680
atttctgtct tcataatcac tgtcctacca ttgtctgtgc ttagaatcta cttgcttaat 43740
gcaggaacat gtgttctcac agagatggaa aatgcaaatg gcgccagaag caagctggaa 43800
attctgaacc attaagaatt tactctctgc caggcacggt ggctcacgcc tgtaatccca 43860
ggactttggg aggctgaggc aggcagatca tctgaggtca ggagttcaag accagcctgg 43920
ccaacatggt gaaacttcat ctctacaaaa atacaaaaat tagccaggca tgatggtggg 43980
tgcctgtaat cccagctact cgggaggctg aggcaggaga atcgcttgca cctgagaggt 44040
ggaggttgca gtgagccgag atctatctgc accattgcac ttcagcctgg gagacagagt 44100
aagactccat ctcaaaaaaa aaaaaaaaaa aaaagaactt actctcaaaa taaatacgtg 44160
tggctgactc cacatatggt agggccaact gtataactag aagttctcca aataacttct 44220
gtggagaaaa aaaagtttat taaaggttaa cttttttaaa gtgctaacta gaaccttact 44280
aacactgaga tcgcaccaat tgtttataac ttagacaggg ccgggtgcag tggctcatgc 44340
ctataatccc aacactttgg gaggccgagg caggtggatc acttgatgtc aggagttcga 44400
gaccagccta accaacatga tgaaacccca tctctactaa aaatacaaaa attagccagg 44460
cacggtggta cacgcctgta atcccagcta ctggggaggg tgaggcagga gaatctcttg 44520
aacccaggag gcggagattg cagtgggcca agatcgcacc attgcactct agccccagca 44580
acaagagtga aactctgttt caaacaaaca aacaaaaaaa aaaacctctt ggaccaggaa 44640
aatatttttt aagggaggag tattttatca ctggcattgt ttaggattgc aggcacatga 44700
tgctaatgaa aagcagacta actattagtt ggttttatta ctgtttttga actctctctc 44760
tccctttttt ttttttttga gacagagtct ctctctctgt cacccaggct ggaatgcagt 44820
gactgcagtc tcagctcact acatcctctg cctcctcagt tcaagtgatt ctcgtgcctc 44880
agcctcccga gtagctggga ttacagggca ccacaccagg ctaagttttt gtatttttag 44940
tagaggcagg gtttcaccat gttgcccagg ctggtctcaa actcctggcc tcaagcgatc 45000
tgcccatctt gacctcccaa agtgttggga ttacaggcgt gagccaccgt gcctagccct 45060
gtttttgaac tctctagaga cagtccagcc ccttattact tgtcctgagg cagctgctcc 45120
cttcacctgg ccccccgcat tgtgttccgg acccttgtcc tggtggtgct aaagaatatc 45180
tctgtcgatc ctttggggac tggggaaact gaggcccagt gccacgcgat gccatttgtt 45240
cagggaagat taggtcatct gctaggtccc cagtcacttg accttcttcc cagacaggaa 45300
gaagctgctc tgggtctctc agtgctccac gtgtctttgc acattgaaat gttttctgat 45360
tttttttttt tttttttgct gttacattta cttttaaaaa ataacaagca ataaaatgtt 45420
acatttgaga aggttgaaat gagaattgat ttgagttaaa ttctagcaga tttttcttag 45480
aagaatgata tcatcatctc cagctacctg caattgatct actctgaatt aagaaagaga 45540
cttccatttg ttgtttatat tttgcactct tgatgtgttt ctttaaatta tggtcatggg 45600
ccaggtgtag gagctcacac ctgtaatccc agcaccttgg gactctgagg agggaggatc 45660
actggaggcc aggagttcaa gacctcgtct gtacagtaaa ttttaaaaat tagccaggca 45720
tggtagcatt cacctgtagt cttagctact tgggaggctg agatgggagg attgcttgag 45780
ccagaacttt gaggctacag tgagttattt tcacgccact gccctctagc ctggctgaca 45840
gagcaagacc tgcctcaaaa aaataagtaa aaaataaatt aaatttcaat cattagcagt 45900
cattaggata tttaaataca gtatgttgaa tcaaagttac gcatgtgtgt attttttttt 45960
ccagagagtt gtttatcatg tgggttttaa tttaacttta aaaaaatgtt ggctggacag 46020
ttgcccaaat ggtatcatca gccatttggt tgagaacgta tgtcctgcgg gctcctctgt 46080
cactggagtt ttgctagctg acagccactg gctagttaga gactgcagtc agcacagatg 46140
caggcgtgga cttgcgcacg taaccatgtc aatgcaaagc catcacttct taaaaattct 46200
gaaccctgct gtctgagatg gtggtgcagc ggatagaact ctgctctaag aggcagtagc 46260
taattccatg tcttctttgc ccttgactag ctgagtgact ttgcacatgg ggcttgcctc 46320
tctgttgcct tgtctgcaaa gtggaatcat cttttccttg ctagacagaa ggtggaccct 46380
ggacctatgg cctttttgag tttccccccc gcttcttaga aggacctctg atcctactga 46440
gtttaatacc cacgggttaa taattgggaa aagcaaagga agcgcttctg tttaggtaat 46500
tatatgcatg tttttgtctt tttctggctg gaaagatatc caagccactg ggaaggtccg 46560
tggctaccca gggtagccct ctctggggag ggctgctata tccaagagcc cctcatgaga 46620
atttgaaaat cgaccatggt agggcctgct gacttttgac agctaatggt gtgctgagaa 46680
ttgtccctcc aaagatgcct ttccattccc tcgggagagt ctgggcagcc cctactgggg 46740
gctgggatgc tggctcttcc ctcagcctcc accccaactg ctctcttccc tcctcccctc 46800
cccagccccc taatttctct cacaaggctt tgttctgcag caacctttcc taatgcagtc 46860
ctggcctctt cgcagcttca ttacataacc ttccgtggac tcctggtcca aggatcaccc 46920
cagaaagcca gtcagaggta ggcacgcagc tggggtccat ttacttacct tccccacccc 46980
ctcggaactc agaggtggtg caggaatttg gactccaaga attaacagct ccaccaccat 47040
caccagagcc aaaactcagg atgcatgtgc ttcatctgct gcttatttcc agctgagagc 47100
cagtggtgcc atggttcctt agggagccgg tcccctgatg ccggctcctg gccccaaatc 47160
tctctgatcc gggctcttcc agaatgtctt gtctccacca tcgcctttga ccaatggtgt 47220
ccctttgcct ggtaatgtcc cctttgcctg atgatggccc tgtcactcct ctctttagca 47280
cagaggaggc tgtttcatcc cttcaagcct gccctccctt caagtcttag ctcaagttca 47340
ccttctccgc agagccttct ccaatcttct tgactacgtc tcctctcagc tccagcaacc 47400
tctgtctctg gcactgattc cttacttagc taagagaatc acagacactt ggggctcagg 47460
acaatctgct ttctctcttc ttacccatgg ccttggactg tgtgtacctc tttgtctcca 47520
ctcccaaacc caacccccag agggcagaga gcatgttgtc tgtccctttg ctcagcatga 47580
agccatgcgt gtggtagatc ggcagagttc cataacttgt gttgaccgag gggtcacttt 47640
gctctgaaat tacccctgtg tccttcagta tttgcacaga tagcttcctg gccagaccga 47700
atatatccaa gggcatggcc cacctctgct cctgtttcca ggtccctggt gggggttagt 47760
tcatgccttc ctcataatct gcccactggc ctggtcctca aggtcttccc aactgctcag 47820
ccagagttga gaaaatgggt cgctccatcc tgtttgtgtc gttctctcct tcctggccca 47880
ctctcctgcc cacaggtatc caggggctgc ctgtagcatt agaggacata catgcacatg 47940
cgtgggcatg ggacactcac gtagcctcca agcacagcat caataatgca ttctgtgctt 48000
tatagcatgg aaagctgctc taaactttat tacacagtgg acatgtctga agcagctccc 48060
aaatccaccc ctgagtgtgt tggaattggc aagcctatca cttgggagtc tagttttttt 48120
gttcgttaat aatagatgct tcctgtggcc ccagcttggc aattttgatt taaagtgatc 48180
ttaactgaag agactaatgg acgggtctga atttgtgcct tttaagcaca aagtattgct 48240
cttaattaac tggattctat cctttgagca ggcagaggcc ttcccccaag ggcgtcatta 48300
acgatccaca tctggacatc ttccaaagcc ttcttctgtt tcaggccaac cgcaggtgtg 48360
ttcctgaaca cccaggaggc tatgagagcc acatatgcct cccaaataca cacagtgtgc 48420
atgcccaggg acatagagca gtgtgcaaag tcccattcca tctctctcca cctgggagag 48480
gatggctctt ctgtctgatt catggctcaa agtggtaaag gagctcccca ctccccgtcc 48540
cacgcctact cagagtctgc aaatatgtat gcgatatgag agctcgtcag ttagctgtct 48600
tcagtgtggc gcacatttga ggagtctgac tcccctccag cacaggccaa tgtgcactgc 48660
tctcctatct ttgtaccccc actgttgcac tgtgcagagg ttggagccat agaagtacca 48720
gagctgtgaa aggagaggcc ccctctcacc tctgccctgg tctccatccc cactttctct 48780
aggaagctag taggtgctga caggggagag aagggagggg aggggtccag aaacagtggc 48840
tcatgcctgc aatcctagca ctttgggagg ctgaggcagg aggatcattt gaggtcagga 48900
gtttgagacc agcctgggca atgtagcaag accctatctc tacaaaaaga aaaaatgtaa 48960
ttagctgggt gtggtggtgg gcacctgtag tcctagctac ttgggaggat gaggtgggag 49020
gattgcttga gcccaagagt ttgaggttac agtaagctgt gattgcacca ctgcactcca 49080
gcctgggcaa cagagctgag accctatctc aaaaaaagaa aaaaaaaaag aaaggagaga 49140
gagagaaaga aaagaaaaga aaaaaaaaaa agaagggaag ggaaagccca gaagagtgtg 49200
gggagaggag gcggccgtca ttctggggcc ctcagtgtgc acaaccagat aacacatgct 49260
ctgtgggctt ttgtaccatt ttgcttgagc ataaagaaag gaaggctgcc cctaaataga 49320
aagcactctg gaggcaaaca aatctgactc caatcctggc cctgccactt tcccagctga 49380
ggacttagac aagcacccta gcctcttgga cattctcaga gccatctgct gcaagtgggt 49440
gctgccatac ccaccttact gggcaggctt gggggaccaa gggtggtaaa tggctcagtc 49500
tttcatgatg cggccacaca gcaggtgcgc catccaggtc catttctttc cttcctttcc 49560
cccaaatcaa gttgtcatta aagtactagt ccacattaat gaaatcaact gtattaattt 49620
tctatttgct gctataataa atcatcagaa atttagtggc ttaaaccaac acaaatgtat 49680
taccttacag ttctggaggc cagaagccct ccataggtgt cactgggctg aaatcaaggt 49740
tttggcaagg ttgcggtcct ttctggaggg tccaggggag aatccatttt cttccttttt 49800
ccagcttcta aaggtttcat gcattccttg gctcatgatc ttctatagct atagtcagaa 49860
aaattttcca tcaatcatct tcaaagccag caatggcagg atgagtcctc acatcacctt 49920
gctctgacac cagttctctg cctccctctt ccacatgtca ggaccctcat gattactttg 49980
ggctcactct gataatctgg gatgatctct ctattttaga gtcagctgac tgggaacctt 50040
aattccatct acaaccccaa ttcctctttg ccatgtacag tgacatattc acaggttctg 50100
gggattagga cgagcctgtc tctgaaaggc tactttacat gaaaattcat ttttttaatt 50160
aagatttttt tttcctcttg agacaaggtc tcactctatg gttcaggctg gagtgcagtg 50220
gtatgatcac agctcactgc agcctcgacg tctctgggct caggtgatcc tcccacctca 50280
gcttccctag tagctggaac tacaggggtg agcccccatg cccagctaat tttttttttt 50340
tttttttttt gagacagagt ctcactcagt cacccaggct ggtgtgcagt ggtgcaatct 50400
cagctcacag caacctccgc ctcctgggtt caagtgattc ttgtgcctca gcctcccaag 50460
gagctgggac tacaggtgtg caccaccacg cccgactaat ttttgtattt ttagtaaaga 50520
tggggtttca ccatgttggc caggctggtc tcaaactcct gatctcaagt gatccaccaa 50580
cctcagcctc tcaaagtgct gggattacag gtgtaagcca acatgcccgg ccccagctaa 50640
tttttaaata ttttttttgt agagatgggg ttttaccatt ttgtctaggc tggtcttgaa 50700
ctcctgggct caagcaaacc tcccaccttg gtctcccaaa gtgctgggat tacagcatga 50760
gccactgcac tcggccttaa gagaagattt aataattaat actttacaac aagatctgga 50820
agaggtggga tgagtaacta aatgaggata caagtaaccc gggtcatatt tgctaatacc 50880
cttggtcaca ttgaacttga tatcttatca gattttccta atcagctcct ttagcagcag 50940
tgttgcagca tcttatctca ttttgttttt tgtttttttg cctagcacat gcctgtaaat 51000
cactggattg aggtgtttag atgtttgttg tcctttggat gcttcttata aatccatatt 51060
tcatggctcc ctggaaagtg ctatgcaaat gataagctgc aaggatggaa aggaaattgc 51120
agtgctcctg aattgtaaat gggcttttac gaggaggttt ctaattactc gctctttctc 51180
ttgaactgag gagttgaagt gtaggtggca gatccataac agataatcat gtgtgtgatg 51240
tgacttcagc ctgagcgtcg aggaccaagt cacagagcag gaacagccac tctccagtgt 51300
ccttggggct acgtctgagg agaacctggg atttcatata tgacctgcac tggctggggg 51360
gctctcttga cgtaacgtgt tccctctgag catgttacag attctgacat tcttatgttc 51420
cttctgtgga gagacatgta cttagtgacc taactcactt tagcatattt ttgctcatcg 51480
tttgtgtagc ttaaaggaat cagataatta ccccctcccc actactttcg gaagcacaaa 51540
tgcaatgccc tagaattgta ctggggactc aaaaagaaaa gagagtagta aaatctatta 51600
aaggggacaa agacagccta tatactacaa gctttctatt tttatggcag agaatgccat 51660
tttctaagta aacagagaac tgcatttgac ctgcaatatc aaatgcatgg atttgatgct 51720
ttggaaagca actgttttct gcgttaatct gggtgtcttc cgtgaaatgt cctcctgcct 51780
ttggcttaaa cactagcttt gtctacagcc attccatcct gaacctgccc aatcttgtct 51840
gaatcctggt ttcaccactg acaagctgtg tgtccttggg caagttactt cacctgtctg 51900
tgcttcagag tcctcatctg tgagttgggg aatctggaca gaatctaccc catagggcgt 51960
agtgaggatg tgttgaatta tcccaagtgg ctacacagag taagcactca aatgatgtca 52020
tcgttgtcat gattgctgtt accagagcct agagttcatt ctgatactcg agtctgtggc 52080
ccatccagcc caggtaagga atagttggag gagttgggca tgttcagctt gaagaggaga 52140
cgacagggga tatgggatag ttgaatctgt gaagggcccc ctgggatgaa gaactggcat 52200
gttctgtgtg gctccagggc actgagcagg acccatttgc caaagtctca gggacacagt 52260
ttctagctat agacagaaaa attttctgtc actcagagga tgaaaataga atgagccccc 52320
ttaagaggta atgagctccc tgtcattgga aggattccag aagagctagg taaccacttt 52380
aggtgctatc aaggggcttt tttctttaaa gtcctttcca aaagcttctg agattgcata 52440
aacaatagga agccatcttg gtgctttaac acaaactctc cccagtgatg agggttgagc 52500
caaagccaga ttggcaagca gagaggagac ttgtgtacaa ggagttcctc gagtcaattg 52560
ctttttcctt gttctagcca gccagagggc tcctgttgga aaacaggaga ccggagaggc 52620
tgaggcctga ccaaaccagc ttctgcaggc cagctgggag gccacaactc ctacctacgg 52680
gaaaactgaa gggcatctct atttttagat tagcaaaaga aaataaattt aagtttgagt 52740
ctcctttgca acttttaaaa gacatcttta ttgagatgat cattcacatt ctataaaatt 52800
cccccacttt gagttacaat tcagtggttt tagtcttcct tgatgatttt gatggtcttt 52860
tcttaaggct cttggaagac ccagaagcct ctcagacaca ggtgggtgtg gagggcgtag 52920
cacagaggca gacttctcat ttcctgggtc tcccctttaa tgactctcag agacccctcc 52980
ttccccctgc ccctggcttc taccccaggg gtgtagagtt ttgccatttt ccaagcagaa 53040
cttcatttcc tcttctgtgt ctacactctt tgtgcttctt tcttgccagc tttttctcct 53100
ttgcccgccc ttccttcctt ccttccctcc ctcccccctt ccctccttcc ctctttccct 53160
ccttcccccc ttccaccctt ccccccttcc ccccttccct ccttccttcc ttccttcctg 53220
cctgccttcc ttccttcctt ccttccttcc ttccttcctt ccttccttcc ttcctggtat 53280
gtgactaatt tctgtttcag gacataaatg ttgtccaggc tgttctttgg tctttctgtt 53340
ggataatgga catttggcat tgagagaggc tgctttttct gaaatcatgt tcttggggcc 53400
cagaacctag gtgtgtgctt ctgactttgt tttcttcctg atccaaattc tgatatgtcc 53460
atttaaattg atctagaccc acagggcact gtgggacaga tcctcagtgg aacatgactc 53520
tgtaacgaga gcattttgtt ttgtcaaaat gagaacatat tattgccttt catctgattg 53580
taaacataat acatgtttat aaaacagtat aatgagacaa aaatgtagac actaataagg 53640
gaaaatctcc ctaattgtat ttctcttcac agagaaagcc cctgttgggc atatatactc 53700
tagtttgttt atttgtttga ctacacatat atgtattctt ttcttatgta taaaaattct 53760
gaacatgcac atttctgcaa ctactgtttt cacttgatga tgcatggacc tctctagagt 53820
gtacgtttct tcttccttac aaagcagttg gcttcgccca gggtgcacca ggacacggtt 53880
ttggctctgt ccccagggtg tcacgggacc aggggatgat ctcacagggt ctgccatctg 53940
ccctgcctgg ccggaggctg catcgagagg gccaaggggc accacgtgtc gtgggtactg 54000
tcaaacaaga gccttcagag ccttccacag tctttctttt gcttcccagc attgcttccc 54060
cgctggtgga ctctgaatct agaactagct ccaggcgcct ctccaaattc agacgggagc 54120
tggggcacta ttataatgca aatctaggca aagccctccc aataccagga tccagaatgg 54180
ggtggggccc tttgccctga aaagctgttt agtttgaaaa tacaaacagg agacagaaaa 54240
gtttggctaa attaatggat aaagttttaa cgatggtaac catagtaggg ttcatcgaca 54300
gccagcgatg gttctgaaca cttgacatgt attaactcac ctaatcccca cattttacag 54360
acaatgcaaa ggaggctctg ggaggttgag tgacttgccc caaagtcgca cagctcctaa 54420
gtgaaggatt cggagtggac tccaggcagc ctggtctgac tccctgcact gcgctgtgct 54480
tatctctggc cccaatgccg ccatgcagaa gtgtctgggg gcactttgtc tctgtcagac 54540
agaattcgga gatgtgtatg cttgccctgg tatggcactt ctcttttttt gagacagaat 54600
ctcactctgt caccctggct ggagtgcagt ggcatgatct cagctcactg caacctccgc 54660
ctcccaggtt caagcaattc ttgtgcctca gcctcccaag tagctgggat tatagatgtg 54720
caccatcgtg cctagctaaa tttttgtact tttagtaaag atgttgtttt gctgtgttgg 54780
ccaagctgat ctcgaacttt tggcctcaag tgatctgcct acctcagcct cccaaagtgc 54840
tgggattaca ggcatgagcc accatgcctg gcagtgtggc acttcttacg tgtgttcagc 54900
ggacactgtt tatcttctgt ccctccaaga cggtgctgag ctcaggtcgt tcattactgg 54960
cagacaactg ctgatttcca acagaattgc catcctcttc tcccctgcga ctttcagagt 55020
gtgacctcag actcaaaaat tagaagtgaa aacatcttaa aaactatcac cttttcttcc 55080
taatcctcct ctcccctccc tgtcttcctt gttgtcccca tctaatgaac tatcatggca 55140
aaaagagccc atttctggtc attttctgtg gcctttcaaa ctcccaccta ccccactgct 55200
cctgggtgca ttacccgaaa gctgagactt cagtgcagaa agtgccaggc cctctgtccc 55260
cccagatcgc cttccttgtc ttccctgtgc ttgcctgtca cattgtgtgg gttccagcgc 55320
tggaaggaat gaggaacaga ttctctggtt ctccttttga agtttacctt cgctccacca 55380
cttctgagac cttcccggaa gttgcccctt gtttctctcc tctccagggc tgccccagag 55440
ctgcctctca cctcttcctg ctgtcacccc accaccatca gggcagaagt tgggacaaag 55500
cctctcctac tggctcctgc ttttctccct taggtccagc ctcctcttct ccatcttcag 55560
gagtctcctt ctccactcac acgtcatgac ttcagcacct cgcatcagtc cagaatatga 55620
ctgcttgttc aagtgccacc tttctcatgc atttttttct agtgacaatc acagccaccc 55680
tgtggggcag gagtgtcatc atccccatgt ttcaaatgaa gaattgcagt tcagagaggg 55740
caagtgactg gcccagcctc aacagctagc cagtggaccc caccagggct tctgactcca 55800
gtccgggttc cctttccacc caaatccatg gagggagctg agccgagaac aggtgtcctt 55860
caggaagacg tgaagccaaa gcctccacct ccaaactcag gggcccaggg agtccaggca 55920
cccatccact cacaaggctg gatatggtgc attccaggag aggggttggg ggcgagtggc 55980
ctctctgtgt acccgtgggg atagatgcgc aagtggcatc gccacatcgt gagtcctggc 56040
ttcatgggtg agctccaggt ccaacgagaa gccaagcagg gggcccttca agctcagctt 56100
tgggcccggg tcggggtaca gggtagagcg ggcctcccca gcccctgcca tgaggccaag 56160
gcagtgcatc gttcgcagcg tacattcaga aaccaaagcc taggagctgg ttatcattcc 56220
ggtttacagc tgatggaaga gcaggtgctt ccgagaaccc acagtgctct ttggccagtg 56280
acccaagggt gcctctgaga ggcctcgcag cacccggagg tgctgctgag gcaacgccct 56340
gactgtaaga aggaccattc atcctcagag agtggccgtg atgctgctgc gacagtccca 56400
ccatccctcc cgactctcac tcccaacaga cttcccactg taaagctgaa ctctccagca 56460
aatcacctct cgccagactc tctcctcact ctctctgggt ccactagagg ttcctcagcc 56520
tctctttgcc ttggttttcc cagctgtaaa atggagcaaa gagggcctat gtacccacaa 56580
aggtgtggtt ggagcgactc ctcctacatt agggcctcga gtggggcttc atgattggtt 56640
ggtggaggtc tccaaaccca cccagtgcca ccgaaggctg agactgcaga tgcaatgcca 56700
caggtgtcct tcctcagcct gggcagctga acatcatgtg taaaacgggg ataataagat 56760
aataacagcc ccttgcacct atgtggctgt gaggattaaa caagataaat gtgtaacagt 56820
gcctggctat agaaatattt actcttgtta ttaagggaag aatatgtgtg gctaaaaagg 56880
gatcgaagat gtaaaagcca atccctcccc ctctagcata tttaagggta atgttgagtt 56940
ggtttgtgga ccatttgctg cctgttagag ctggaaggta gggaccccct ctcaacagcg 57000
atgctacaaa ttatacccat tggaggtcaa ccaaaagaca aagcttattg gctggacatg 57060
gtggctcaca cctgtaatcc tagcactttg ggaggccaag gcaggcggat cacttgagat 57120
caggagttcg agaccagcct ggccaacatg gtgaaacccc atccctacta aaaatacaaa 57180
aattagctgg gcgtggtggt gcacacctgt aatcccagct actcaggagg ctgaggcagg 57240
agaatcacta gaacccagga ggtgaaggtt gcagtgagcc gagatcgcac cactgtactc 57300
aaaccgaggc aacagaggga gacgcaatct caaaaaaaaa gaaaaaaaga caaagcttgt 57360
taataccagc atattgttaa gggaataaag taggctgcag aacaactggt gtaatatggt 57420
gccatgtagg gaaaattaca tgtgtgcata ggagaggggt ctgcaaggtt gtgccctaag 57480
atgttagagt ggttcctttg cttttctctt ttataatttt gtatttgact tttaaataag 57540
gaccataaat cacttttata aaatacattc tctccagccc ctactactcc tttaaagaat 57600
aagagtggtt tgcccaagaa agacagtttt ttttgctctg gttttcttga ttctgacatc 57660
agaggaaact gcttctcatc cacttggggc tctgggttca ggggattcat ttcaggcaga 57720
ttaaagtggt gaccaggggc attcgtggac acagggaggg acaggagcac catcagtttg 57780
tctcacacaa ccactgtcat cctcactgaa ggctgttgcc tgatcaaaaa cagtattggg 57840
ccaggcacgg tggctcacac ctgtaatacc accactttgg gaggctgagg tgagtggatc 57900
acttgaggtc aggagttcga gatcaacctg gccaacatgg tgaaaccttg tctctactaa 57960
aagttcaaaa attagccagg cgtggtgggt gcctgtagtc ccagctactt gggaggctga 58020
ggcaggagaa ttgcttgaac ccgagaggta gaggttgcag tgagccgaga tggcaccacc 58080
acactccagc ctgggcgacc gagggggact ctgtcttaaa aaaaaaaaaa aaaaatatat 58140
atatatatat atatatatgt caaaaatggg gtagttttta gatctatagt agttctaaaa 58200
acaaaggcca tccaagcatg acagatttac aagcactatt ggctattcca gtagttacaa 58260
tggaggagag aagcttttag ttaaaacaaa caaacaacac aacaaaccca gaaaccttag 58320
gtcaaaacca aaattgtcct ctcagacaca atctgggaat tttctcatga cagtgggcat 58380
tagccaactg acatcagcag caaccatccg tgtgcacaca gtggcaccac ctcctcccaa 58440
aaagcagcct tcatctatgc cctcatacaa tcgttgatta ttctctttgg attgaggccc 58500
ggaattattt aagtttcttc ttgccagcat gagtctttcc tttctgtatg ctccttatct 58560
tctctcttta atttggcagt tctgcttgaa atctgggtct ttcattagta gtagttcaat 58620
ttggttccag aacattctgt ggtgtgatgc aatgtgacca gagctcacac ttcagagctc 58680
ttcaagggcc agtcttactg agcacctccc agtggctgcc tgtgtgctgg gcgccacttg 58740
tggtgggcag gagagaggag gggacacaaa aggagacaca gctccttctt agaagctcaa 58800
agttggggac cagctgccac agaagagtat gtttagcatc tgagacacca agatccagcg 58860
tcacaagggt gtttattaag cctcctcatc tctttctttt tctttttttt tttttttttc 58920
ctcaggcagt cttactctgt cacccaggct ggagtgcagt ggcatgatct cggctcactg 58980
catgcaacca ccacctcccg ggtttaagca attctcctgc ctcagcctcc ccagtagctg 59040
ggattacagg tgcccaccac cacacccagc taatttttgt gtttttagta gagacagggt 59100
ttcaccatgt tggtcaggct ggtctcgaac tcctgacctc agatgattca cccacctcgg 59160
cctcccagtg tgctgggatt acaggtgtga gccaccgcgc ctggccttgc tgttgattca 59220
tctatagtat gtttgacttg atgacctcca gttaccttag acagaggttc tcatctaagc 59280
tccaactttc catttccttt gtcctcgtct ttccccttaa cccctccaca tttctctcaa 59340
aatcacccca cttctaaaaa atactgttta tttttctttt aaatttcaaa ttatctatac 59400
tcattgaaat aaatcaaaat agcatggaat aagcgaaaaa aatggatccc acccttcccc 59460
actcccattc cctagggcta accatagtta accatttaat gactaggttt ttttgttgtt 59520
gttatttttt atttatttat tttgagacag agtcttactc tgtcacccag gctggagtgc 59580
agtggtgtga tctcggctca ctgcaacctc tgcctcccag gttcaagcat tctcctgcct 59640
ctgcctcctg agtagctggg attacaggtg cctgccacca cacctggcta atttttgtac 59700
ttttggtaga gacagggttt ctcaatgtta gccaggctgg tctcgaactc ctggcctcaa 59760
gtgatctgcc caccttggcc ttccaaaata ctgggattaa ggtatgagcc accgcaccca 59820
gccctcctgg gctcttttcc tttagttgca ctcgctcccc gctcctggag tagagggatt 59880
tccgagagac tgtgggctcc agccttcacc taggcccagg actaggatgc ctgccctaac 59940
atttatcttt ataccttaaa gcaaaacagc tggaccataa gcattcaaga acaaactgtg 60000
aataaggaga aagttctccc aggaaacaag agctttagtt ctgttgggcc agcccttata 60060
ttccttagct gttaccagtc actgcttgat ttaatctcgg ctatcacttg gcctgacagg 60120
tctgctgctg gtgccaggat gtctgggttt tgaagcctgg ctccattaca tacttcctgt 60180
gtgaccttgg gcaacttact caacctgtct gttcctcagt ttccccagct gtattatgtc 60240
agcataatag tttgttgtgt gaattaaatg aggtaataac tggaaatgct tcaaacatgg 60300
ttcctatcat gagaaatcct gctttccgcc taaatgtgct ggaaaattcc tggtggtgca 60360
gaacaggaga ccagagcaaa ggaaagacag ggtgcagaag ccaaaaatta ccttggagaa 60420
caaagcgcat gttaaggtta tttttggatt ctaggtttat ctctgcttgg tcttcagtta 60480
cctgcaagag atccatttag gggatttttg tttgttttta acgatagctt tattgagata 60540
taattcatat gccataaaag tcactctttt aaaatgtttc cggtatattc acaaggctgt 60600
gcagccttcc ctgtccttga ttccagtctg agtttttaac tgaagggata aggaggacca 60660
cgctttcccc agaccagaac cgcgggccag ggggcgattc tgctgagtca ccgcgggcgc 60720
ctggtgcgcg gcggcggagc ccgggacctt ccttggctgc cccctagcga gggccgcagc 60780
gcagcctgag acacccgccg gggccgctcc acggccgtcg gatttagact ggaagctcgg 60840
tccaggtccc cagcttgatg cgcccgcggt gtaggagacc agcccgactc gggcttcccc 60900
tgagcccctg gactcttgac tccagcaggg cctgggtaat gaacgtcagc tcccctttcc 60960
caaaggggtt gctctgttgg gaaggcaccc gtttgataca gtagcataga gatgggtttt 61020
agcatcaaaa tatcagaatt caagccttgc tctctgctta ctagctgtgt gaccctaaaa 61080
aggtttctga acgtctctga gcttcagttt cctcatcatt ccttctcacg gggtggttgt 61140
gagcattaca gagatcctct ctgtgaagcc cctgtgagtg gctcatcctg agggctgaaa 61200
taaacatgtt attaataatc caaaactggc aagggatgtt gactggtccc cctcccttgc 61260
ccaaggagct ttctagaacc tgagttatca ttaccaaact gtactgcctt gagtaagaaa 61320
gttagaagga atgggaagga tggtggcagg tggaggaagg cggattggtc atcacctcct 61380
tgcagcaaga aacagcccca gatcgtggga aacctacaga cctgctagac agactaggag 61440
caaaagctgg ggctttaaga atccccaggg aggttctcct gagagagtag ccagttggat 61500
tttgtaagca gagatttgtt tggggaggag gtgacaacgt agggagcaga ggggcaaagc 61560
tgtcgggaat cctgccttga gggcagggat gtgtgttggg gggagttggg tcactggggc 61620
tcggtggcct tgggcaagtt tctacctctc aggtccttta cccacctagg gtcgccatcc 61680
tgcccacctc acaggttaca gtgagcctgg atgcactgtc atgggcaggt gcccaggaaa 61740
atggcagaca tgttccaaac agcacgcagc attccccagt gatgcccagg gtcaccttgg 61800
aggtgggcga gatgcctggg gtttctcgtc caccccacaa cacctcaggg gacagccaaa 61860
gctgtccctt caggtaagct gcacagaaga tgtgaactct gctgcaaaga ctctattctt 61920
tgggagcaaa agggacccag ggtctcacct gcacatccct gtccctgagg gcctaggggt 61980
tcttggaggc cccagccttg gcaaaatgag gaagaaggtg aaggttgtct gggcccctgc 62040
caggctcctt cctcggccac gcactcccct tcctgcacac acacccttct ccctccaccc 62100
catctccatt gttgtcagaa aagtcacaat aaaaaggtcc atattgtcta gttcccatac 62160
ttttaatttt taaaatttta tttatttatt tatttatgta ttttttgaga cagagtctta 62220
acccaggctg gagttcagtg gcatgatcta ggctcactgc aacctctccc tcctgggttc 62280
aagtgattct catgcctcag cctcccgagt agctgagatt acagatatgt gccactatgc 62340
ccagctaatt tttgtatttt tagtagagac ggggtttcac catgttggcc aggctggtct 62400
cgaactcctg gcctcaagtg atctgcctgc ctgagcctcc ggaagtgctg ggatttcagg 62460
tgtgagccac cgcactcggc tccacacttt tcacttatta aaagactgtg gtgtccatca 62520
atggatgaat gaataaacca atgtggacta tccctcccat tacccaagga atgaagcacg 62580
gagccgtgcc aagatctgga ttcacagtga aagaagccag tcaccaaaag ccacgtgctg 62640
tgtgacttcc cttatacgaa atatccagaa gagatacatc catggtgaca gaaagtagat 62700
gagcagctgg ggactggcga aggggagaag ggggagcagc tgtctatgag gtccagcctt 62760
tcttctgggt ttggtgagaa tgttttggaa ctagatagag gtgatagttg tacaacattg 62820
tgaatgtact aaatgccact gaatcattca ttttaaatcg ttctttacgt tgcatgaatt 62880
ttaagtcaat caaaaacagt tgtttgaaaa gagaaaagcc tatgggtagc ggcagcagtg 62940
attggattta tgattcgatt ccatggctca tccctcccct gcctcacccc ctcgccctcc 63000
gacgtcttct tcttttactc tgaactgtta tctttgttct catctctctc tctctctctc 63060
aaccctgcag acacttttcc ctttctttgt ctgcccccac cctccagatt tccgtgtctc 63120
cagtgtctcc ctacgaggca tgaattgaga ctgggagggt gtgattctga agaaggcacc 63180
aacagtgact cagctagccc cttcccccac cccgcccccc gggcctcaat ttagctaaaa 63240
aaccacaggg acggactcag gaggcaatac ctttccaagg gtccctaaaa aatgtcccat 63300
tttagtgtcc aggtttcact caactttagt gcctccccta aaatgtgttc cttacctccc 63360
accccactgc atctaagtca ctgcctgaga aaacaggatt gaggaaagga gaaaggaaga 63420
gagagagaga ggaggagaga gagagagagg gaggaaggct gatggattta gaaaagaaga 63480
aaacaagtgg tctgaggaaa acagccttgg tgtgtttatt ttcctgtctg tgtatcgctt 63540
ctcggccttt tggctaagat caagtgtatt ttcctgtctg tgtgtctcgc ttagattaca 63600
gggatctgtg ggtgatgaca cgtctggtcc aggctgcgta gtcacctcaa gggcatgctt 63660
attgatgtgt ttttcaattc actatctttg catgggagtc ccaggccaag aggcacagct 63720
gcgccatttg tctgttggtt tagatatcct ttatccagtt cttccagaga aatcatcctg 63780
cccttctgga ggaggtgggc agcaggggtc agagatggga gggaaaggaa ggagccaggt 63840
ccttggctag gatgccaggg tcccctgcct ctcacctggc ctgggctgga ggcctcctgc 63900
tgtcctgtca ctgatcacta ccccgcccca gcctcctgag ttagaagaca caggctaaag 63960
tagagtattt cttcattgaa aaacccatac aaaataaagg ttcataaaaa ataaaaattt 64020
agactgggtg ctgtggctca cacctgtgat cccagcactt tgggaggcca aggcaggtgg 64080
atcgcttgag ccctggggtt catgaccagc ctgggcaaca tagtgaaacc ccatctctac 64140
aaaaaataca aaaaattagc caggcatggt ggtgcatacc tgtggtccca gcttctcagc 64200
ctatggaccc acatagaata caatgtcagc ataagaaggg agccctgggg tcaccaaatg 64260
gtttgggcgg caaagaacct gaaggttgag agaagtggct tggttaccca gctgttggat 64320
gtgagacctg gccactgctt cttccatacc ctagacctgc accctgacat ctcaagtaaa 64380
aagttggggg atgttttatg gtccaggatg aaggaagggc agtgaggggc agcggagcat 64440
cactttgcat ttctgtctgc ctcttactgg ctgtgtgacc tggggcaggt aacttcccag 64500
actcctggga atcataacac ctatgatgat gatgatgatg atgatgatga tgacacctac 64560
ctcaaggatt gccctgaagg gtcacagaga tgcctgcaag gcacctgcat ggagcaagcg 64620
ccccttctct ggcaggtgct gggtgagcac tacctgctgc caggccctgg ggctatggca 64680
ctgcgtgacc ctgcaagtcc tacctggcga agctgtcgtt cttgtgctca gtcagtgttg 64740
gttgtaagac tgagaagagt cacttcattt tgctctccag ggacatcttt ctgggtccta 64800
ttttctgcct atgtcaagta gcgcctcaag gatgctcctg aaaatgggct tgtctttctt 64860
aacatggcag gtaggtccca aagcattagc atggggcagc tgacctagcc cagccaatgc 64920
agtgcagtga ctcttgcaac cgagtctaat cagaaggtcc atgaacctac gagcatttcc 64980
tgtcccagga tcagggtgga ggctgagcct ccctgcttag agattcttcc catgcattcc 65040
acttttttcc ccaaaagaaa atattgaccc ttgagaggca cacagtttat ttattttgca 65100
tagtaaatag tagcctgtat tttaaggatg agttgatttc tgcatcagcc cctgtaggtc 65160
atcagccttc tattggtgca tctgactctc tctagccctg cagggatggt ggagggggag 65220
gggaaggagg gatctttatt ggaaaccagg acagtgagac tcattgccct gtcatctgct 65280
ctgtggtgct gaatgaggca gcccaacaga gaaataccct gagcgagcat ccccagcctc 65340
caaaacagtg gcgcattgcc ctgagtcctg ggaatgacct ttgattctcc tgctcctgac 65400
ttggaaccca tggaaacctc tagaagcagc tgaggaaaac ccaacatgaa aagcagaact 65460
ccacactgag aatataggag gtgatcggaa catacaatga ttcttgctaa gaccgattca 65520
cagtttttct tttttttcga tcgaagaaat actggagaag cctaaagaag gagtctaaaa 65580
actctggcac gtgggccaaa actgtccttg agctaagaat gattttcaca tttttaagtg 65640
gttgaaaaat gaaataaaat aagatgatgt tttgtgacac atgaaagcta tgggaaattc 65700
aaattctaat atctataaat agtgttttat cagaacacag tcatgctcat ttatttatgc 65760
tcgatggctg ctttcccgct acaattacgt tgagcagtta caacagagac cacgtggccc 65820
acaaagcctt acaatattta ctatctggcc ctttccagaa aaaaatgtgc cgactcttga 65880
ccttaacctc agcaatttgg gaggccgagg caggcggatc gcttgagctc tggagttcat 65940
gaccagcctg ggcaacatag taagactcca tctctacaaa aaatacaaaa cattagccag 66000
gcatggtggt gcacacctgt ggtcctagcc actcgggaga ctgaggtggg aggatcgcct 66060
gagcccagga agtcgaggct gcagtgagct gtgatggcac cactgcacct cagcctgggc 66120
gacagagcaa gaccttgtct ccaaataaat aaataatgca aagtaaaata aataaaacca 66180
tataaaaagg aatcaattta aaattataat gaaagctggc cgggcatggt ggctcacgcc 66240
tgtaatccca gcactttggg aggctgaggt gggtggatca cgaggccagg agatcgagac 66300
catcttggct aacacggtga aaccccgtct ctactaaaaa tacaaaaaaa aaattagccg 66360
ggcacagtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaatgtct 66420
tgaacccggg aggtggagct tgcagtgagc cgagatcgtg ccacttgcag tccagcctgg 66480
gcgaaagagc gagactccgt ctcaaaaaca aaaacaaaaa caaaaacaaa aaaaaattat 66540
aatgaaagcc aaggggcata gtagaacaaa ttttctagag ctcattaagt caaatgagtc 66600
accagttagt aaaacgcagt cacggggaag agagggcagg attctttgaa gcagcggctc 66660
tcctaaaaac aacccaccct tgtccagctg ccttccctcc tgagggtgtt ccctttgact 66720
gtgtgacccc catcccctat ttcccaaccg tccaagccca cctctagcat aatacgagct 66780
tttaatccct ctccctgacc ccaacccgat tttgaagccc agtctagtat tttctcaaat 66840
acacttcttg gctccattcc ttcctttcca tcacctctgc cttttcactg catgcttgga 66900
ccactgcagt cagctcccta tgaacagttg ctctctaccc atccaatcgg ccccgcctgc 66960
tgctgccaaa ttcaccgagg gcacctctgt ggtgctgcct gtggacaaag tccaagccag 67020
ccacctcacc cacctacagg tgagtgggga gcagccagcg tgtccagtgg tttaccccat 67080
cgccacagac ttggtgatgt gtcgatgtgc agagaagggg tgttggcagc cacaacacaa 67140
gcaaccccgc cccatgtgag atctaagatg ggcgtgctgg gagccacctc tgagaatcca 67200
acagaaggca gaggggagaa cggctcacac ggcacaaaca ctccttcctt tttttttttt 67260
ctttttcctt tttgaaagga gtctcactct attgcccagg caggagtgca gtggtgcaat 67320
ctcagctcac tgcaacctcc gcctcctagg ttcaagcgat tctccagcct cagcttccca 67380
agtagctggg attacaggta cactccacca tgcccggcta atttttgtgt ttttagtaga 67440
gacggggttt ccctatgttg gccaggctgg tcttgagctc ctgacctcag gtgatctgcc 67500
tgccttggcc tcccaaagtg ctgggattac aggtgtgagc catggggcct agcctccttc 67560
catttaaatg tatgcctaat ttgcccattg agaacggctg agacgcattt taagtggcca 67620
gggtctactt agagttagtg ctcatgacca ggcccaggtc aagcctggct ggccagatgg 67680
tgcctttgac ctgctctgtc tctgtgcaaa ggaatgagct gaaggatggg ggtgcagtgt 67740
gtgggcagtg ggctggggct ggcaggactc agtgactaag ggaagagaac tttcctcact 67800
accagcctgt cttttcaggg caccgcgggg ggctttggga cttggtgatg aacacagcac 67860
agagagctgt ccagcatgcg ggtccctggc ttctcacact tcccaggctc cttcagaggc 67920
tctctccaaa gggagctgct ctctctagaa cccatgaatt tggaatatag gcaaccactg 67980
cattggggac cactgacctc aaacatagag accagagcaa atggggctca tcacgtgaaa 68040
ctcatctgga actctagcag gttcttttat atatatatat atatatatat atatatatat 68100
atatatatat atatatatat tttttattat tatactttaa gttctagggt acatgtgcac 68160
aacatgcagg tttgttacat atgtatacat gtgccatgtt ggtgtgctgc acccattaat 68220
tcatcattta cattaggtat atctcctaat gctatccctc cccactcccc ccaccccaca 68280
acaggcccca gtgtgtgatg ttccccttcc tgtgtccaag tgttctcatt gttcaattcc 68340
cacctacgag tgagaacatg ctgtgtttgg tttttttgtc cttgcgatag tttgctgaga 68400
atgatggttt ccagcttcat ccatgtccct acaaaggaca tgaactcatc attttttatg 68460
gctgcatagt attccatggt gtatatgtgc cacattttct taatccagtc tatcattgtt 68520
ggacatttgg gttggttcca agtctttgct attgtgaata gtgccgcaat aaacatacgt 68580
gtgcatgtgt ctttataaca gcatgattta tattcctttg gttatatacc cagtaatgag 68640
atggctgggt caaatggtat ttctagttct agatccctga ggaatcgcca cactgtcttc 68700
cacaatggtt gaactagttt acagtcctac caacagtgta aaagtgttcc tatttctcca 68760
catcctctcc agcagctgtt gtttcctgac tttttaatga tcgccattct aactggtgtg 68820
agatgttatc tcatggtggt tttgatttgc atttctctga tggccagtga tgatgagcat 68880
tttttcacgt gtctgttggc gaactctagc agcttctttt cacaagttca tggagagagg 68940
tttcccactg agggaatcac atctgtctga tcaaaagagg cttgggaaat ggctctcctg 69000
ttcattccct gaaaacctct gatggaacca ctgccactgt ggcagcccca gcactggcac 69060
cccagccatg attggtgccc cagccacatc tctgctgtga gccccagagc cctggttaat 69120
taatcatcca cgtgttgatg gggagaggcc cattcacaaa agcgacataa agcccaggga 69180
gacgtggccg tggcaagaag ggtgtgggac tacattccgc ccccaactga gagattcaga 69240
aaccagaaaa aaatggaaaa acatactgtg ctcttgggtg ggaaaactaa atatcatgaa 69300
gggagcaatt tttatagttt tggcctataa tacaattcca gccgaaatcc cagtggaact 69360
ttgagaattt gcaggaaaaa aaaaaatgtc taaagtacat ctggaagaca aacttacaag 69420
aaggtcaaat aattttgaaa aagaaaatga tatctaagcc cacctagaga ataagacttg 69480
agatccaaag ctaaatcagg aggctctagc aaaattgaca gataagcagg acagagtgca 69540
tggtgcattc acctggggaa gagggcagat tggtctacaa ataggcctgg gtccactgac 69600
tttagctgtt atatttgggg agaaactttt caacctcact ccatcttaaa cctaaaaata 69660
ttccagatga attaataaat ataaaaaatt agaccactaa aaatgtagaa gaaaatggat 69720
gatctttcta taccatagag caatggaata aatcacaaag gaaaacagat ttgactatat 69780
aaaacttaaa ccctgcccat caaaaaccat cagaaaccaa aataaaaggc aaccaactgg 69840
agaagatagt tgccacaaat atgatcaagg gttaatgtta ttcataaatt aagagcccac 69900
acaagtcatt agaataagca ctgagacctg aacagacaag caaaaagaat gagagtgggt 69960
cggcgcggcg gctcatgcct gtaatcccag cactttggaa ggctgaagca ggcggatcac 70020
ttgatcccag gagttccaac accagcctga gcaacatggt gaaaccctgc ctctacaaaa 70080
gtcataaata ttagccgggt gtgatggcac acgcctgtag tcccagctac tcaggaggct 70140
gaggtgggtg gatcacttga gcccgggagg tagagtctgc agtgagccaa gatcacaccg 70200
ctgcactcca gctggagcaa cagagtgaga ccctgactta aaagaaaaaa aaaaaaaaag 70260
aggagaaaaa tgctgatctc actagtaatt aaaacatcag gccaggcgca gtggctcaca 70320
cctttaatcc cagcactctg ggaggctgag gcaggcagat cacttgagat caggagttct 70380
agaccagctt ggccaacatg gtgaaatccc gtctctacaa aaaatacaaa aattcgccaa 70440
gcgtggtggc acatgcctgt gatcccagct actcgggagg ctgagacagg agaattgctt 70500
gaacacggga ggcagaggtt gcagtaagct gagatcgtac cattccagtc cagcctgggc 70560
tacagagcga gactctgtcc cagaaaaaat taaaacatca catatttaaa caactctagg 70620
atatcattta aaaaaacatt aatagactgt tttttagagc acttttaggt tcacagtgaa 70680
actgagtgga aggtacagag acttcccgta tgttccctgc cctccacgta cagcctcccc 70740
cactgccaac gtcctgcacc agagtggtac acttgttaca accaatgaat cctcattaac 70800
atatcattat cacccaagtt catagtttac attagtaaaa catcatcttt catctataag 70860
cacaaaaatt ttttggcatt tatttaggtg tatgattaac tcagtgttga caagactcac 70920
acttcatacc cacttgcact gcatctgaga agcaattggt gtctacagcc gctacaccct 70980
caacaagccc gatcttgttt gaaaagcaat tggtgatgct tctcaaaatt ctatggacaa 71040
agtcagccgg gcatggtggc tcatgcctgt aatccctaaa ctttgggagg ccgaggcagg 71100
cagatcacct gaggtctggt gaaaccctgt ctctactaaa aatgcaaaaa ttacccaggc 71160
atggtggctg gggcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga 71220
agcaaggagg cggaggtttc agtgagccaa gattgcacca ctgcactcca gcctgggtga 71280
caagagtgaa actccatcta aaaaaaaaaa attatggaca aagtttttca aaaagatatt 71340
taatgcaact ttatttgtaa tattggaaca tctgaggcca tttcagtgct aactattagg 71400
ggatggttag gaaaatatgg tacatatgtg gaaaggaaca tttggtagtt agtgcccctg 71460
atgtttacaa aggcttttag tgaccaacaa atgctcatgc tataatctta tgtgaaaaaa 71520
gcaagtagca taattgcaac tatattttta atgcatagaa taaaaggcta gaaggaaata 71580
tcacagatcc ttgacataca ttcccaaacc tttgtaaatc cgcggattca tgaaaacaga 71640
cacatttgca caagtgcctg atcttttctg ttatacattc attagaagtc aagccctggt 71700
gccacaaagt atctgccttt tcaaatgtga tcagaatgtt ctcttttgct tcaaggccat 71760
ttttcacgaa gcagtggcat ttttgcctct tcatcagagt caccgtgtgc cctggaggac 71820
tgagaacagc agagccgttt taggatggga cagggcagcc aggaggattg ggctcactcc 71880
ctactgagtg cctcactccc gtacagcccc catagaggaa gaggggttca aatttattcc 71940
tcagccagat ggcatgtgcc gcctgtcctg gaatttcaca tcacttatga tggaccaaaa 72000
ttccaaaagc tgaatccatg attgtcaaag tctggtatgg caggatgtca acagtaatcg 72060
tttctgggca gagggatgat tttctcttcc catcttgctt tgtataaata cattttctat 72120
aataaggttg tattactttt ctcatcaaga aatagcaaag tactgtttta ctcaaaatat 72180
gaatagagcc aggcatggtg gcagcttatg cctgtaatcc caacactttg agaggcggat 72240
atgggaggat cactttagcc caggagtttg agaccagcct gggcaacata gtgagacccc 72300
cgtccccact cccccaaaga aaacccacaa agcatttatc ctggattatt cacaggggcc 72360
aaaaaaaaaa aaaaaaattc aggcctccta tagccatgag ctacgaatat gaaaatatgc 72420
aaatgtgtaa gaaaagccag cacatccgat ttttactttt actttcacac ctctgtccac 72480
catgttccaa gagaagaaac ttggtcattg aaaggaatag atcaaatcca aagaacaaaa 72540
ccactgtgct cattaaactt cttagtgttc acaaagcttt agctgcaggt tgaatggggc 72600
aacccgaatt ggctggctca cctgggctgc agggagcaga gatcgcgaca ctgcactcca 72660
gcctgggcaa caaagcgaga ctctatctca aaaaaaaaaa agttcataaa ttcaaagtta 72720
tgaattattt ttaaaataat aataatttac aataaagatg aggacaaagt gtgagtaaat 72780
ggtggtttct atccagctct gttgagctga agtggcatct ccctgctggg gcttttgggg 72840
aagaagggtg tgtgttgctc ttcagatccc aagcctcatg cccctactgg gccctgtggg 72900
gtgcttctca gcccaccagg agagccaccg ttggaacaca cacgtggggg acctggtggg 72960
tgccggtgtg gtgaatgggg gccacagcct gactccagga agccagcaaa ctcggagctg 73020
gaggagtcag gacacccccg atgagtcaag agttggtttt gctgccagtt gacatctgat 73080
tgaaccatct cttcacttct ccgtgcctca ctttccttac cagacaggct ctgctgatgc 73140
tgtccctctc ctgttcagtc gtgccctcac cgttaaagag aaagagcaaa ctgctgggca 73200
gcagcattga tttttttaat gaagtggaaa gagagctggg aataacaagt cgggcccacc 73260
tcacctgcct cacctggtgg gtttatttgt tttgtttttt tttttttgtt ttgagacaga 73320
gtttcaccct gtcacccagg ctggagtgca gtggtgtaat ctcagctcac tgcaacctcc 73380
acctgccagg ttcaattgat tctcctgcct cagcctcccc agtagctggg attacaggca 73440
cctgccacat gcctggctaa ttattgtatt tttagtagag atggggtttt accatgttgg 73500
ccaggctggt ctcgatcccc tgacctcagg tgatccaccc acctcggcct cccaaagtgc 73560
tgagatcaca ggcgtgagcc accatgcctg gccgtcacct ggtggtgttg aatatgaact 73620
gctgcggtgt tggtaaatta agcaagcaga tagatgtaaa taacgcttgg gcaggaatat 73680
ggagcacggg atgaggatgg gcggccaact gttagagagg gtagcaggga ggctgagatc 73740
tgcctgccat gaactgggag gagaggctcc tctctctctt cacccccact ctgcccccca 73800
acactcctca gaacttatcc tctcctcttc tttccccagg tgaactttga accaggatgg 73860
ctgagccccg ccaggagttc gaagtgatgg aagatcacgc tgggacgtac gggttggggg 73920
acaggaaaga tcaggggggc tacaccatgc accaagacca agagggtgac acggacgctg 73980
gcctgaaagg ttagtggaca gccatgcaca gcaggcccag atcactgcaa gccaaggggt 74040
ggcgggaaca gtttgcatcc agaattgcaa agaaatttta aatacattat tgtcttagac 74100
tgtcagtaaa gtaaagcctc attaatttga gtgggccaag ataactcaag cagtgagata 74160
atggccagac acggtggctc acgcctgtaa tcccagcact ttggaaggcc caggcaggag 74220
gatcccttga ggccaggaat ttgagaccgg cctgggcaac atagcaagac cccgtctcta 74280
aaataattta aaaattagcc aggtgttgtg gtgcatgtct atagtcctag ctactcagga 74340
tgctgaggca gaaggatcac ttgagcccag gagttcaagg ttgcagtaag ctgtgattat 74400
aaaactgcac tccagcctga gcaacagagc aagaccctgt caaaaaaaaa agaaaagaaa 74460
aaagaaagaa agaaatttac cttgagttac ccacatgagt gaatgtaggg acagagattt 74520
tagggcctta acaatctctc aaatacaggg tactttttga ggcattagcc acacctgtta 74580
gcttataaat cagtggtatt gattagcatg taaaatatgt gactttaaac attgcttttt 74640
atctcttact tagatcaggc ctgagtggcc tctctttagc aagagttggt tagccctggg 74700
attcttactg tagccacatt aataaacaac atcgacttct aaacattcta taataccatc 74760
ttttggccaa attgacttcg cctcttcctc tctctttcca aatgaaatgt gtttcatttc 74820
actgtcagac cacatggttg gggaccccac agagcacaca gccctccctc tgccttccca 74880
tgctggccct tcacccactg ctggagtgcc aggttggtcc aagggttgga ccaagttgtc 74940
tgaggttgtc tcaaggttgg tcgaggctgt ctccgcgctg ggttgtgcta caaggagccc 75000
ttctttccat gggtgtggct ggcagtgagt gctcacagca acagcccaca gtgcagcccg 75060
agggcaggat ggactcagtc cctgcctcca tacccatttc taaggaggca aaatggcaaa 75120
cactctactt ttctctttta atgctaaaaa taagaaaaca ccttgcagcc cagggtatgg 75180
gtagtgcatg gaagccgtgg agttgtgagg tgggaagtga cctctgctgg atatgtctat 75240
tcaggaagat tgctggagtg ggtggggtct ctgggaggtc ccctgagtgt gggaagctgg 75300
gaccaccagc tttctcgcac agggagtggc catcccagct tggagaggtt ccaggactgg 75360
ttgggaggca cgtttcagat ttctatctgt tgaatcagcg aagatattgg attatgagga 75420
atttgggaat taggaaagtg ggtgcaggtg ggttgggggt aggtgaagga agacatgggc 75480
gtattggggg agcaggggct gctcagaggt gttccagaag ctctgggtga ggaggtgaga 75540
gggaccgggg aatgcagctc ggcccagcct ccctgcctga ggtcagccat cacgtggtga 75600
tggcaagatg gaaatgtgct ttctgactgc tccagccagt gctgccagat tcagctcccc 75660
agggagggca cctgagaggc tccaagccag gagatctgtt ttctcctttg ttttgttttt 75720
ttttgttttg ttttgtttta ttatacttta agttctaggg tacatgtgca caacgtgcag 75780
gtttgttaca tatgtataca tgtgccatgt tggtgtgctg cacccatcaa cttgtcattt 75840
acattaggta tatctcctaa tgctatccct cccccctccc cccaccccct gttttctcct 75900
ttgaatcctt cttagaggcc gggcgcggtg gctcacgcct gtaatcccag cactttggga 75960
ggctgcggca ggaggattgc ttgagcccag gagttccaga ccagcctggg caacatagtg 76020
agacctcgtc tctacagata ataattttaa aaattatccg ggcatagtgg catgcaccta 76080
tagtcccagc tactcaagag gcagaggcag gaggatcact tgagcccagg aggcggaggt 76140
tgccgtgagc caagatccca ccactgcact ccagcctggg cgacagagac ccccatgtca 76200
aataataata ataataaata aatccttctc agtcccttcc tcactgtgtc cccctccact 76260
gaatttttcc acctcctctc ccacttcccc cactcccgct ttccctctcc ttctctcccc 76320
actccatctt tttctttctc tgctgtttct cgtccctccc tcctctccat cccacaacac 76380
tgcctaccct gtccctgccc caccctggtg ctcaggatgt gtgaagtgag gggtggtagc 76440
ccccaagacc tcaaccccga aggttagcct gttgaaacca ctttctccca gctgcccccc 76500
tggcagttgg tgctgctggg ggaaactggg attgggggcc agattttgcc tcttttcctg 76560
acaaagagag atgaagagtt ctctcaccag gtgcctggga ctggggtgtg ggtgtcccag 76620
cctatcccag cgcatctgtt ctgcatcatg attaatagtg ctgctttcag ccgggcgcgg 76680
tggctcacac ctgtaatccc agcactttgg gaggctaagg tgggcagatc acaaggtcag 76740
gagttcgaga ccagcctggc caacatggtg aaacctcgtc tctactaaaa atacaaaaat 76800
taaccaggtg tggtggtggg tgcctgtagt cccagctact tgggaggctg aggcaggaga 76860
atcacttgaa tctgggaagc agaggttgca gtgagccaag atcgtgccac tgcactccag 76920
cctgggtgac agagtgagac tccgtcctaa aaaaaaagga gttttgctct gtcgcccagg 76980
ctggagtgta gtggcgccat ctcggctcac cgcaacctgc gcctcccggg tgcaagcgat 77040
tctcctgcct cagcctccca agtagctagg attacaggcg cctaccacca cgcctggcca 77100
gttcttgtat ttttagaaga gacggggttt caccctgttg gccaggctcg tctgggactc 77160
ctgacctcag gtaatccgcc cacctcagcc tcccaaagtg ctgggattgc aggcatgagc 77220
caccgtgccc agtcaactcc ttctcaaaaa aaaaaaaata gtgctgcttt ctctttcaag 77280
tgtcctgatt tgggtgatag taaatgccac tctacttata agggatctac ctcagaatgc 77340
taattgggac atttttgtag cactctactg ttggcagcag gtgatgctca caacagcccg 77400
tgagggtgga tgacgtccgc ttcacagatg acaaaggagc ctcatgctca gaccgtgggc 77460
tgccagagca ggtccatggc tgcagcccca catggaccat atttccccct tgtcactctt 77520
tccaccaagc tcccttggaa cttcagttat taagctctct tgggtggaat ccaagttaga 77580
atcacaacat gtgcctcata tggattgtgc cagtgaaaaa tgacattcta tttagaggca 77640
gggcagcctg gcttagagtc agtttaaaat atgtattatg ctgcaacaaa tgtaccatga 77700
tcctgtaaga tgttcacaac aagggaactg gatgtggggt atactgtctg tactaacttc 77760
acaagttttc tgtaaatcta aaactgttcc aaaataacaa gttcgtttaa aattaactcc 77820
aggagaccag gtacggtagc taatgcctat aatcccagca cttcggaagg ctgaggcagg 77880
tggattgctt gagcccagga gtttgagaca agcctgggca acatggtgaa atcctgtctc 77940
taaaaaaaat cacaaaaatt agccaggtgt ggtggcgcat tcctgtagtc ccagctactt 78000
gcggggctga ggtgggagaa tcatctgagc ccaggagttt gaggctgcag tgagctgtga 78060
ttgtaccact gcactccaac ctgggcaaca gagcaagacc ctgtctcaaa aaacaaaaat 78120
gaaataaagt ccaggaaaga agtaggtttt accactctta ttttctgaag agaaaactaa 78180
atttaatgtg taaagtgagg acaagttcac caagttagtg tttgagttgc ctaaaatatg 78240
tttgctaaaa ctattcaaag ctttcacata aaacatgatc agaagttcta tgccaaaaca 78300
tatgtgtgtg tatatatata tgcactatat atactgtata taaaaatgca aaatctaaat 78360
tgccaacctt ttagaaattg ctctgaaagg aaagcatttc aagataattt gcttacccaa 78420
agaatatact ttccaagaaa gcaagtaata cttaaggtgt tcataatcct catcaaatta 78480
attcttgcta ctgaaagctt acaaggagct gttttgatgt cgggtgtgac aggtttgact 78540
tggcagaagg tgtcacttta ctaacaacat tttaaataag tgacagaaga caagaaacta 78600
cacgttaaat gccagaacaa agagtgtcta agtggatgct aagagttgaa atatggctgg 78660
atacctgccc aagagagctg aaaagtagat gaaagttggt tacctataaa ctagtgcacc 78720
ctaatgaatt aaaaggtgtt gatgagttaa cttgttatgc cttccagata agacatgcaa 78780
atggggcttc ttcctccttc actacttcca agggatttaa caaggagacc aatgcaaatg 78840
ataaggactg tagggctcaa gctggggaca gattggggaa agggggacca tcatgcccat 78900
atagatgtcc ctgtgccctg gcagtcaagg ctgctgaaaa ataacaaaac ccagaagtct 78960
gcgtgatgct gcctctccat ttgtccaaag ccttcttgcg gcagtttgca ggcttttgca 79020
aaagctccag gaccaaggag ctatgttcat gctggaagct tgttcaggat tagctgttct 79080
ttgtgggatg ggtgcagcca gggccaggtg tccagggaca gtgttttaac aaagggcatg 79140
aggtgtctga tctcacagtg gaactccact tgcctttttt tcatcttctc attctgcttc 79200
atgcacagaa ccagccccat cctgaaactg actctaaatt actcccgccc caggtggagt 79260
gcctttctcg gagttcaaca gagccttcct gtcgcccaag ggacaactcc actgaatgcc 79320
caagccacac ccaaaaccta acaagtaaaa accaaattct gtgctccccc atcctgggcc 79380
attcctggtt tctctactgc tgttggtgat accaccatca gcttgtccat catgaccctg 79440
gccagttcct cccacaaccc tccacagcac ccagggacct cacctccatt ccatccgaca 79500
cagatctcct caccacaaac cttggttttg caacagcagc catgagacct ttacaccctc 79560
cgcccttcat cctgtccccc actgaggccc cagagccatt ccttaaagca gcgcgccaca 79620
aactataacc cacaagccaa ttctggtacc cagcctgttt tgcacagcca gtgaactgac 79680
aatgatcttt tcatacagcc agaaaaacaa aacaaaacaa aaaacaacaa aaaaaaaccc 79740
caccattctg agcatgtgac ttccatgttc aagatgtctc atgttcagaa aggcccctgg 79800
aaaaggagga aggggagctg ggcacaaagg gagaccctct cagctgagct cctcccatcc 79860
agacattttc ctggacttcc tatccaatga cttcccttag cttcttatca gccacccctg 79920
tctgcccagg aggctggaag atgtggcctt ttaactgggc acagctctgt cctctatcat 79980
atcagggctc tgttcccaag gagggtagag agaatggaca ccaggtggac cctcagcagt 80040
ctgtgccaca gagggagtgt ttgcaatttc cagactaaaa gtccccatgt gcttgacggg 80100
gtatgtgact acaacgtgat gcttgacttt tcctcatatg accagagcca ctttgtccat 80160
ctggtacaat gtcagctatc tgctaggggc cctccaggat tcccagtcaa ttccatatct 80220
gcatcaccac cattggcact aaataaaata aaatactcaa gttcctgctg gtgagcatga 80280
gcagtgctac actgggccct tcaaccaagg tgacatgata atgactgaaa ataatcactg 80340
ccacttattg gggacgtctc atctgccagg catggtacaa agtgctttaa ataagcattc 80400
aacaatttca tgctgacaga agccctgtga gccagtggag ctactactat gcccattata 80460
caggggagaa aactgaggca gagagaggtt aggtaattcg ctcagcctca cacaaccaat 80520
aggtggtgga gccaggattt gggccccatc tgcctgactc tctagaggct ctatcttcca 80580
gtcttccaga gttgagtcta agccatgaat aggacaatta gacagcagag gaaacccatt 80640
cagccaccat gtgcatgaag agtaaggaat ttctgtcata cagaggggag tgaattcact 80700
gagctgagag ctgaggaacc attgatctga tggctgagac accactggga agactggaga 80760
ggcttttctg ggcatgcagt gccaggcaca ggaggagctg agggaagatg actaagaggt 80820
actggcaaag aattcagaaa ttctgatgga agctttacat gttaccatca catccatcca 80880
tctatccacc catccatcca cccatatctt cctccctcca cccaatcatg catacatcca 80940
gtcatctata caccacccac ccacccatcc atccatccat ccatcccttc atccatccca 81000
tcatccatcc aattatacat acatccaatc atatatctgt acataatcca ttcttccctc 81060
ggttcatcca tccatccatt catccatcca tccacccatc ccttccttca tccttcctat 81120
catccatcca atcatatatc tgtacataat ccattcttcc ctcggttcat ccatccatcc 81180
attcatccat ccatccaccc atcccttcct tcatccttcc tatcatccat ccaatcatac 81240
atatatccaa tcatacatct gcacatcacc agctcatcca tctatccatt tatccatcca 81300
tccttccttc catccatcat tcatccatca tacatacatc taaccataca tctctacatc 81360
attcattctt ccatcgattc atccaattat ccatcattcc ttcctccatc catcccatta 81420
tccatttgat catacatata tcatctatac atcatccatt catccatcca tccatccatc 81480
cacccatatc ttcatccaat caatcataca tacatcgaat catctacaca tcacccatcc 81540
atccatccat ccattcatct atccacccat ccatccatcc atccatccat tcatctatcc 81600
acccatccat ccatccatcc atccatccat ccatgtaacc atccagtcat atatccaatt 81660
acacatccat ccagttatac attcatacat gcatctaatc attcaattat acatacacac 81720
atccatataa ttctacatcc aattatacct ccatccaatt acacattcat acacccacct 81780
aataaattat taattcatat atccatccat ataattatac atcaattata catccatcta 81840
atcattcagt aattcaccca ccatccagtc atctatccaa taatacattc atccaatcat 81900
ccatccatcc atccacccat tcatccatcc atccgtccgt ccacccatca tggtatgagc 81960
catgatttac cacgatggtc ccctgtggac agcccaggtg gggcagaact gaagggaagc 82020
ccagggctgc ccccataaac atttgcctcc tttacatgga tgagaactag atccacatgt 82080
ataaatcctc atgatttgaa ggtgctttta ccaacattca ctcatgggat tctcccagga 82140
gctctaggag gaggcaggta gagttgaggt catctcacgc attttacaga tgaggaaacg 82200
gaggccctga gaggcaggtc caaggccacc tgaccagaaa gaagtggaac tgggacttga 82260
acccagccat cttgcccctt ggtcccatgc tctctagcct gtaactcctg cttcctggtg 82320
gggcatctcc aggaggaccc tatcggctgg ccatgggcct gccctggagt cttttgctct 82380
gtgtggccat ccttcctccc tcaggagagt gtgtgctccc agagcacagg ctgtatcttc 82440
tgagcatttt gtcccttccc agtacctagc actcagctct gtatacattg ggctctcaag 82500
aattctcaac cttccagagt gtaaggcctt gacctgctca gccctggata ctgcatgatg 82560
cattgataag cccataaaat aaccagggca gattgactcc cagtggccaa agtgccacag 82620
ggaagggaca attcagccct tctaggagga ggaggaggta gttttctcat ttctattaag 82680
gcaacaaaag ctgccttact aaggacattc ttggtggagg gcgtgactgt caaccactgt 82740
gatcatttgg gcctctcttg cccaggcttc ccattctgaa aggacagttt tattgtaggt 82800
acacatggct gccatttcaa atgtaactca cagcttgtcc atcagtcctt ggaggtcttt 82860
ctatgaaagg agcttggtgg cgtccaaaca ccacccaatg tccacttaga agtaagcacc 82920
gtgtctgccc tgagctgact ccttttccaa ggaaggggtt ggatcgctga gtgtttttcc 82980
aggtgtctac ttgttgttaa ttaatagcaa tgacaaagca gaaggttcat gcgtagctcg 83040
gctttctggt atttgctgcc cgttgaccaa tggaagataa acctttgcct caggtggcac 83100
cactagctgg ttaagaggca ctttgtcctt tcacccagga gcaaacgcac atcacctgtg 83160
tcctcatctg atggccctgg tgtggggcac agtcgtgttg gcagggaggg aggtggggtt 83220
ggtccccttt gtgggtttgt tgcgaggccg tgttccagct gtttccacag ggagcgattt 83280
tcagctccac aggacactgc tccccagttc ctcctgagaa caaaaggggg cgctggggag 83340
aggccaccgt tctgagggct cactgtatgt gttccagaat ctcccctgca gacccccact 83400
gaggacggat ctgaggaacc gggctctgaa acctctgatg ctaagagcac tccaacagcg 83460
gaaggtgggc cccccttcag acgccccctc catgcctcca gcctgtgctt agccgtgctt 83520
tgagcctccc tcctggctgc atctgctgct ccccctggct gagagatgtg ctcactcctt 83580
cggtgctttg caggacagcg tggtgggagc tgagccttgc gtcgatgcct tgcttgctgg 83640
tgctgagtgt gggcaccttc atcccgtgtg tgctctggag gcagccaccc ttggacagtc 83700
ccgcgcacag ctccacaaag ccccgctcca tacgattgtc ctcccacacc cccttcaaaa 83760
gccccctcct ctctctttct tcaggggcca gtaggtccca gagcagccat ttggctgagg 83820
gaaggggcag gtcagtggac atctgatctt ggtttagtat ccttcatttt gggggctctg 83880
ggtgtggcct gggcctctgg actttggcca cggtgtttgt tccagccctt ctcctaacct 83940
gtcctttcca gacactcggc atctaggtta ttagcacctc gcatactttc tgacatgctc 84000
ctcagtcctg attttgacca tcttctcttg cttcccatct gtgtcagtca agactgcatt 84060
tggctgtaag aaacagaaac cccaactaac tgtggcattt acatgaagag gtttactttt 84120
ctcacataat cagatgtcta gacttggcca gcacctcaag ggtcattgat gctctcctgt 84180
ctttattttc tgtcatcttt agtggttgga ttgttgcctc atggttacaa agtggctgct 84240
gcacttccag gcatcacatc tgcctttgaa gcaggaacaa gttgcaaagt aaagtggcca 84300
aaagggccct gaaactaaat gtgtcccctt aggaaagcag gagttttctt gcaagtggca 84360
atcttctgct tatgtctcat tggccagagc tgggtcttac ggccacccct tgctgcgagc 84420
aaggctggga cattgagcat tttgccgtcc aacctcttta gcagaataaa ccaaggggga 84480
agaacgttaa tagtggcttt tgagtcacta gttggcagta tctgcccctc tatctttcca 84540
tcctccccat ggagtttcaa ggttcctttc tcagtacttc ttcaggctct gcacgttcat 84600
ttggatcttg tgtcttgggg tgaaaaactg gcccaagtgt ctccccaagc atccaccttt 84660
ggattaattt ggaaaatggc tgtcaagtgc ccgcctcttg cttggtataa tgctacagct 84720
ttagaggacg cagcaggcat gggccttgcc gctgaggttc ttagcctcat gagaatatcc 84780
agatcagatt ctcttggctc cttcttagag ccagtgatgc aagacacttc ctgctcatct 84840
tgtcgggacg gttttacaag ttgcctgcca tcctgagaaa gtctacaaaa cgatgccaga 84900
cctcatgcca gcttcccaag ccttgactct cagtgctccc tcaacaggat tctggaagaa 84960
tctcccaaac aagtcgcaat gccctctgga ccctgtgcag gcatgagact caagagcatt 85020
ggctcccacc cctggtggag ggaacactgc tggggctggg atcttgcctg gttgctccgc 85080
ctgcacccaa gacaaccata attaaaatgt ccttcattga acttggaaag ccttcaaagc 85140
tgacaactcc ttatgtgtac ccggaaaggc ctgggagtgt gccagggcat tgctcgggag 85200
ggacgctgat ttggaagcat ttacctgatg agagactgac agcagctcct ggtagccgag 85260
ctttccctcc tgcctctgct gtgaaggtgg acccatccaa cagtcaaatg cctgactctg 85320
gacaggagcg gacctattta ttgccatgca agggactctg cacttttgaa ttgtgggtca 85380
tgggcttgga tttaggggtt agagctggga gaagtcttgg aagtcaccta gagatgacac 85440
tgccattttg cagatgagga aaccgtccaa tcaaaatgga ccaaggactt gcccaaagcc 85500
tcacagcaaa accataggcc cccgcactaa ccccagagtc cctgtgctgt cttaaggatc 85560
atatagttgt aagcaatcat ctggttttca gtatttcttc ttttaaaatg cctggggcca 85620
tgcccagcag tctgtttcac tgcagcgttt acacagggct gccgggcttt cctggtggat 85680
gagctgggcg gttcatgagc cagaaccact cagcagcatg tcagtgtgct tcctggggag 85740
ctggtagcag gggctccggg ccctacttca gggctgcttt ctggcatatg gctgatcccc 85800
tcctcactcc tcctccctgc attgctcctg cgcaagaagc aaaggtgagg ggctgggtat 85860
ggctcgtcct ggcccctcta aggtggatct cggtggtttc tagatgtgac agcaccctta 85920
gtggatgagg gagctcccgg caagcaggct gccgcgcagc cccacacgga gatcccagaa 85980
ggaaccacag gtgagggtaa gccccagaga cccccaggca gtcaaggccc tgctgggtgc 86040
cccagctgac ctgtgacaga agtgagggag ctttgcgtgt ttatcctcct gtggggcagg 86100
aacatgggtg gattctggct cctgggaatc ttgggttgtg agtagctcga tgccttggtg 86160
ctcagttacc tccctggctg cctgccagcc tctcagagca tttagggcct tctggacttc 86220
tagatgctcc tcatcttgcc tcagtcagcg cgtcagttcc agagacttct ctgcagggtt 86280
ttctggggca ggtggtggca gacccgtgcc ttcttgacac ctgaggtcag tccaccctcc 86340
tgctcagact gcccagcaca gggtcacctc ccaaggggtg gaccccaaga tcacctgagc 86400
gcacagaggg tgcagatgac tggaccacac cttttggtga tcttaatgag gtggtcccag 86460
aggagctcag acatgcaatc tagcatccag ttctgggact ctgtctcctt ttcaaacgta 86520
ttcatgtaga acaggcatga cgagaatgcc ttgtcaacat gggtgatggg gaatcaatca 86580
gacagggcgc cgggctcaag gctgcagtca cccaagagtg gctcagccca ccaggcccta 86640
ggaaacgcct gcacagcctg gagctcctgg agtcatttcc ttcatgtctt cttcactgca 86700
cttacgtaaa gatgccagcc attggtttgg tgatttggag ggtgcccagt tgcccaacaa 86760
gaaatgcaga agaggcctag ccaggatttc accagcagtg gagagtagag aagatgtggc 86820
cagaaaagag tttcctttcc ctcctaaaga tggtactccc tgcagctact ggggaagcct 86880
gcagcattct ctagggctct gtgtgttgag agcagcccca ccctggcccc ttctgagtgc 86940
atttctgctt tgtgacttga tccgtgaagt cccctgagat gggcagaggg gatgtcctcg 87000
aagctggggc agagcctcat ccttgaacgt gaaggacgtt tgaagactgt ggcatgatca 87060
caggatgaga tcacagggaa cttgagtttc tctcctcctc tcccttcaca gttatttcac 87120
tgagggaaat ccctcccctg cccagaatga aaactctagc caactcttga cttttccatc 87180
actccaaagt agttgaaagt acattagtct ccacagtggc aaaacagtgt gcaaaagcta 87240
aataattaga acagccagtc ccatgtgaca gtcaaagctt ctaactccat tcaaagttgc 87300
agccattccc ctcgagggct ggcagggagg ggaggggtaa gagaaacagg aaggttctta 87360
ctgagttggt cctggtgtga gctgcgtcac actccctgca gaggtttcaa ggagactctc 87420
tctctctctg tctccatggg gaccttattt gaattcttct actcttaccc cagcctgcca 87480
tctccagcta tcctcccctg aagagccctt ctgctgcgct ggattctggt ggccatgtca 87540
tctcctcggc cccgtgggag tctgaagatc tggctgcagc ctcacctctg aggtcctgct 87600
agttgccacc tcttaaacat gatctgaggc tcccatgcac tctgacctgt gcccacatgg 87660
ggcccacggg aaacacgctg gcaagcaaac tgtgggtgtg cagacggttc tcagggctgc 87720
agcacctgtc ctttgctctg cccccaaagc aaggccagcc catcttccat cctctagtgt 87780
tccttggtgg ggccctgacc acagtccacc aggtccctaa ccagagggga cacacaccag 87840
gtgtcctcaa tgtattgcct tgaaacagtt gtgctgggac tgtgatgggg ggtggccatg 87900
tagccacccc caccaccccc aagccactct ctccaaggaa atcctcctaa agatcccttt 87960
acatcctcca tgtggtgggg aggttctaga gttgggtgca tgtgtcttca gctactgaca 88020
atgcagacct tagttggcac ctcgctctgg cctatcctgt ttgctgttct tggcgctcca 88080
gtgaaactcc ccatgggcca tccagttggg gtgcagtgtg gccaccccct tgcaggttcc 88140
tgccttgctg gagagcacag ggccctcctg gctcttgtaa aacactcccc atggtacaga 88200
gaggccagca gtgatgtgag gcccaacctc cctccatggt gttcccaagc agctcccttt 88260
ctggggtcaa ggggtggcaa agacagtgca gcgtccaatt tctgactcaa gccgggcctg 88320
gctatcgcag ctctgcactg tgtgtgacag caaggcaact cacccagtgc cgtggcagtg 88380
accgtgtccg aggaagcctc ctcacaccct ctgtctcaag gactctggca tttagctgga 88440
cttgctgtag ctctgagcct ttctgccatt gccatcacct tgtcagaaac tcaggccgaa 88500
tctgcactca gagttgtgcc caggcagttg agccaacact tgctcagcga tattgtcaca 88560
tgacaaggca ctgtcaccac tgggcatcgt gggtagcgca gtgtcggctg gatggacccg 88620
gagggtgtct gtgtcatgct agtgctagtg atgggagccc cgtgagccca ttgcccgccc 88680
tcccatgccc tcagcagctg cctggggaca gccaatggcc tgggtgtttc tgaggctacc 88740
acatggcttc caggaaactc gagaaccttt ctctcccttg cctacactct tcacacaggc 88800
ctgtgctggc cagcggtggg gatccggcat tcctatctta ggtgcagaga gtgactgact 88860
cattgcaggc ctgggagata agactgatgg cccagccagc aagatgtatg gatttctcag 88920
aggcagtggc ctctgtcatt gtcctcagga aatgctggtg attctggtgg cctgaggtca 88980
atgcatgtca acgtggccaa cttgccttat aaactttttt tctggacaat tgcgtgcact 89040
gtcctgtaac agtgtcctgt tgtttatgat gcagaaatag gtgtttttaa agcctattga 89100
ttttggtact attaatgtgg tcaggaactt tctcagtctt tcttgtttgg ggtgagctgt 89160
ggcttcctaa acaggaaccc aagacacccc caaaagctgc tcaccagcac tgccagcctc 89220
cctcttacca agtagcaccc gttcaggaca ttctgcgaaa ggcatttgcc cagaagttgg 89280
gaggaaggaa atgtaacatt ttggggcacc taccatatgc caggcaccag gctaaacgtg 89340
ttcacacaaa ttctcttact aaccctcacc atccttctac aagacaaact agtatcttca 89400
tcttggggtt caagatgagg aaatggaggc tcagagaggt tgaatgaatg ccggtgcctg 89460
gatatgaacc ccatctgcct gactccgcaa cccaggcaaa gtctttcctt gaacttccca 89520
gcagccactg cttagacaca gcctccacaa ccatggctca gcagcaaatt gcttctctga 89580
cctcactcag cctgtgtgtc cttgttgagt gaggcattca ggaccctggt cccaaagtgg 89640
agaaagtctt tcctactagg tcatagctac acctgcatgt gggtgctgtg ccttttgttt 89700
agtgaacttt tatcaccagc atcctcagca atgacatttg cagagaagcc agagctgagg 89760
caccttggta ttcttgggat gtgactttcc tgaatgttta agggaaaatg cccgaaggta 89820
cagagagctt ggtttctagt aaacaataac tgtcttgctt ttacccccct tcatttgctg 89880
acacatacac cagctgaaga agcaggcatt ggagacaccc ccagcctgga agacgaagct 89940
gctggtcacg tgacccaagg tcagtgaact ggaattgcct gccatgactt gggggttggg 90000
gggagggaca tggggtgggc tctgccctga aaagatcatt tggacctgag ctctaattca 90060
caagtccagg agattttagg gagttggttc ttatcaaagg ttggctactc agatatagaa 90120
agagccctag tggttttttt ctaataccat ttctgggtaa ttcctaaggc atttagtgtt 90180
ctgaaagatg ctagccttgt ccagcctggg agttgagaat gaatgtctaa cagaaactct 90240
aggccgggcc tggtggctca cgcctctaat cccagcacta tgggagaccc aggtgggcag 90300
atcacctgag gtcaggagtt tgagaccagc ctggccaaca tgtgaaatcc tgtctcacta 90360
caaataaaaa aattagccgg gtgtggtggt aggtgcctat aatcccagct actcaggagg 90420
ctgaggcagg acaatcgctc gaacccagga ggtggacgtt gcagtgagcc gagatcgcat 90480
cattgcactc cagcctgggc aacaaaagca aaactccgtc tcaaaaaaaa aaaagaaact 90540
caaatatgtg tgacaggcga ttctcactgc aggctgccct gtggctgatc caggagcaag 90600
gccttaacca tgtcatcccc aagcgattgc ttgtaaactt tcttctgtgc agccttcaac 90660
ccttattatg attttcttct caggaaccaa actgctgtat tcaagaaagg cagctttgtg 90720
taatcattta tcataaatat cttaagaaaa atcctagaga ttcctaattt taggaaatgg 90780
gagacctatg gtactgatat aatgtgggct gggcttgttt tctgtcattt gctagataaa 90840
tgaacttgag agcctactgt aaaatgtgga agcttctaga ttgcagaagg gctggaaaga 90900
cactgttctt ttctcccgag tgatgggatc tgtccagtat ttagagctgc ctctgaggcc 90960
atctgattct aggagactct gcctcgttga ggatattttg aggcctaact acacattcct 91020
gcccccagag aggtcacagc ctatagcagg ctgatgtttc tcatgtcaca tggcacagaa 91080
aggcacattt tcgttctcag gctaacaaag agcttcaaaa actattagaa gggacagtgg 91140
ctataagaga agaacctcag tcaatgtgtg aaattaacta ggaacctggc tcctgtttct 91200
tttaggtcat gtttttcagc ttaggtaaaa ctagaggctt tgataaagca tgacctctag 91260
aaatcattgc ttttcataaa tggaagtggg tttgagtttt ttctactgat tgttagtgca 91320
ggtgatgtct acatgccccc agaacatatt ccatgcaaca aaaaaagccc aggtcaccgt 91380
ctttgctggg aacttgactt ttgtgctcac tgaattttaa gctttctgac agcagcctgg 91440
aatcatggag ggataaagta cctattagta agatggaaaa aggtgtttca ggttggagct 91500
gcagtctgtt gagagtaagc tatgggaagg cctgtatacg aggggtggac ttttcttctg 91560
taagtgtcca gagaccaggc ctcctgaaga gggcatgggg gcttaactta cctggactac 91620
tgtgtttaca atactcattt atcttgaact cctcctaacc cctgagaatt gctacattta 91680
gtatttgctg agtacttcct agcatcctag ggaatcaata gaacattctc ccaaccaggc 91740
tgggtgcggt ggctcatgtc tgtaatccca gcactttggg aggccaaggt aggcagatcc 91800
cttgaggcca ggagtgcaag actagcctgg ctgacatggt gaaaccccgt ctttactaaa 91860
aatacaaaag ttagccaggc atggtggtac acacctgtaa tcccagctac atgggaggag 91920
taggaggcag gagaattgct tgaacctggg aggtggaggt tgctgtgagc cgagatcatg 91980
ccactgcact ccagcctggg cgacagagtg agtgagactc tgtttaaaaa aaaaaaaaaa 92040
aagaacattc tcctaacctg gcttcttcct ccaggggtgt aattaatcat gtcagtttcc 92100
tcattgatac acacacacac acactacaat cctgtatcca ttacttttca aggtacattt 92160
actatttacg tttggggtcc ttgtctcttt tttaatagtg tttcttaaag tcttgtatta 92220
tatcagagta cagtaacatc ccagtcaaga gcactctagt aagctctagg aggaaagcga 92280
cttccggaag gcagtggaga cctgtcctgt tggggcagca taggggcagc ccctgcctct 92340
ggtcagttct ggcgctcagg ctcagggttg cctctgggct gttcttccca gagactgaca 92400
aagggctccc ataaggcacc tgcagagcct gtgagaagct gaagtcaatg ttttcctgac 92460
accagttgat ctgtgcagga tccattgatt taaccacctg ctgtgtggca tgcactgtgg 92520
tcgatgccag gaacaggaat tggaggggcc catgagcatg gccagtatca caggctggag 92580
gtgctgctgc gctctgaccg ggcctcttgg ggatgagccc atgtcaacca ccttgcctcc 92640
gatggggtcg ggcccacagg ttacctttgt gtgtccatga ccacaccttc ctccccgacc 92700
tcatccaaat ctctttcttt tccaagcccc tgaatccttc agggctgcag gttttgttta 92760
aagcagagct ggtgagttgc ataggttgtt gcattgggac tagatggggt gttcaaagag 92820
ttgggagtta aaaaacataa agggtattta ttaggagaac caaggagtgt aattctcctg 92880
ttcttaatat gcggccaggt taatgaatgt cacgtgaatg aaccagaaaa aaatgaagtg 92940
tgcccttgat cagctgggtt ggtgtgcagc aagctgtgtg accaggggac agcagtggtc 93000
ctgagggccg tcactgtctg ccgtgcagag cccttcctcc cacgggggcc tacctcacct 93060
gtgccaaggg cttgtctgtg gtcagtgacc tggatagatc tgaatggggc ttctttttcg 93120
aggagtctta tggcaggtct ctcagtaaag actccattct tgatgatcac acattttgga 93180
ttttccaaat ctgtcagaga atgggcttga ggcggggttt gtgggcacta gtttcactgg 93240
tttcatttac caaaaagggg agcagaagtc aagtatggtg gctcatccct gtaatcccag 93300
aggcaagaga attgcttgag cccaggagtt cgagaccagc ctgagcaaca taaggagacc 93360
ccgtctccac aaaaatgaaa aataacattt tagtcagacg tggtggcatg catctgtggt 93420
cccagctgct tgggagggtg agatgggagg gttgtttgag ccctggagtt aaagttgcaa 93480
tgagctgtga ttgcaccact gcactctagc ctgggtgaca gaacgagacc ctgtctcaaa 93540
aaaaaaaaaa aagaaagaaa gaaaggaaaa aaaaaactca tgcctgtaat cccagcactt 93600
tggggaccgg ggtgggcaga tcacgaggtc aggagatcaa gactatcctg gccaacatgg 93660
tgaaaccccg tttctactaa aaatacaaaa attagccagg tgtggtggca cgtgcctgta 93720
atcccagtta ctcgggaggc tgaggcagga gaatcgcttg aaccagggag tcagaggttg 93780
cagtgagctg agatcgtgcc actgtactcc agcctgggcg acagagtgag actctgtctc 93840
aaaccaaaaa aaaggggtgg ggggcggggg caggagaaca gtgagaggta gggagaggaa 93900
aggggattct cgctacaccc aaaccagata ccatctagag gctagaatct ttgggaggct 93960
caaattccct agaaagcagg agaagcttct gtagccctcc cgctttccca gtagattaag 94020
cccagggcgg ctccagatgt gtgacatgct ctgtgcccaa ccagagccca tcataggcag 94080
aggaataaca cccacaccag aagggccctc ggaggtcacc acgtccaaga accctcttta 94140
cagatgagga aactgaggcc cagagagggg agagccacct agcgagctgg tggcggctag 94200
accaggagag ctgtcattcc aagcaagcaa aggcaacgag acgagcccag agctgtgctc 94260
ccatctcttt gttagggggc ctgggatgcc ctctcagtgt cattttgtcc aggatgatgc 94320
tccctctctt aagcgattaa tgcgcccttg ctaacctttt gctatcgctg cctcttcaaa 94380
ccagaggagt tgagagttcc gggccggcag aggaaggcgc ctgaaaggcc cctggccaat 94440
gagattagcg cccacgtcca gcctggaccc tgcggagagg cctctggggt ctctgggccg 94500
tgcctcgggg agaaagagcc agaagctccc gtcccgctga ccgcgagcct tcctcagcac 94560
cgtcccgttt gcccagcgcc tcctccaaca ggaggccctc aggagccctc cctggagtgg 94620
ggacaaaaag gcggggactg ggccgagaag ggtccggcct ttccgaagcc cgccaccact 94680
gcgtatctcc acacagagcc tgaaagtggt aaggtggtcc aggaaggctt cctccgagag 94740
ccaggccccc caggtctgag ccaccagctc atgtccggca tgcctggggc tcccctcctg 94800
cctgagggcc ccagagaggc cacacgccaa ccttcgggga caggacctga ggacacagag 94860
ggcggccgcc acgcccctga gctgctcaag caccagcttc taggagacct gcaccaggag 94920
gggccgccgc tgaagggggc agggggcaaa gagaggccgg ggagcaagga ggaggtggat 94980
gaagaccgcg acgtcgatga gtcctccccc caagactccc ctccctccaa ggcctcccca 95040
gcccaagatg ggcggcctcc ccagacagcc gccagagaag ccaccagcat cccaggcttc 95100
ccagcggagg gtgccatccc cctccctgtg gatttcctct ccaaagtttc cacagagatc 95160
ccagcctcag agcccgacgg gcccagtgta gggcgggcca aagggcagga tgcccccctg 95220
gagttcacgt ttcacgtgga aatcacaccc aacgtgcaga aggagcaggc gcactcggag 95280
gagcatttgg gaagggctgc atttccaggg gcccctggag aggggccaga ggcccggggc 95340
ccctctttgg gagaggacac aaaagaggct gaccttccag agccctctga aaagcagcct 95400
gctgctgctc cgcgggggaa gcccgtcagc cgggtccctc aactcaaagg tctgtgtctt 95460
gagcttcttc gctccttccc tggggacctc ccaggcctcc caggctgcgg gcactgccac 95520
tgagcttcca ggcctcccga ctcctgctgc ttctgacgtt cctaggacgc cactaaatcg 95580
acacctgggt gcagctgctc cactccctcg gcctcctccc gtgctcaggc tgtggccgca 95640
cgcgcccctc acgcttgccc gccactctgc atgtcaccag cacccccgct ccgtgctacc 95700
caccttgttt gactctctgg ccacttgatt tgtccacaac ggcccatcag cccacaggag 95760
gtttggtggg tgccttccac cgacaggatg acgggtgccc tcatggtgtc tagaactctc 95820
caaccctccc atgtaggcat aagcagcccc actttgcaga tgaggaaacg gaggctcaga 95880
gaagtacagt aacttgccga aggccaatga gtagtaagtg acagagccag gtttgggatc 95940
caggtaggtt gtctctgaaa gacacgcctg tcctgcatcc cacaacgcct cccaggaggt 96000
gctggagtgt ggacgcctaa cacagagatg tgcagggcac acacagcagg tgacacacac 96060
agcatccaga ggtggcccag agctcatgct gtgcctttgg cccagtgccc tgcccccacc 96120
cactctgcct tgtggcagga agacaaggag cagacacaag atctccctgg tccacatgcc 96180
accacctccc tctgcagagg acaaggggat cctcatgctg gcattggagg gggttgagca 96240
gggcccacct tgagccctca ggagcacgac cacagcagcc ctgcagggag ggattggtgg 96300
gaggagagtc ccaagtatca gggagaggag agttggtgtc ccacaggaga cctcagagcc 96360
acaaggcgag cttgttcata aatttgggac ccttagcatt tcacagttat ttgcagagcc 96420
cagaaatgga tgttactgaa gctcacagtt gcaagcatct gttaaatttt tattagattt 96480
tacttttagg gaaaactttg aaatgctata aagaagcctg tgtttaaaag ttaagacaga 96540
ggctgggggc gatggctcac gcctgtaatc tcagcacttt gggaggccaa ggcaggtgga 96600
tcatttgagg ttaggagttc gagaccagcc tggccaacat ggtgagaccc tgtctctact 96660
aaaattacaa aaaattagct gggcgtggtg gcgggcacct gtagtcccag ctactgggga 96720
ggctgaagca ggataagtgc ttgaacccag gaggcagagg ttacagtgag ccaagatcac 96780
accactgtac cctaagcctg ggcgacagag tgagactctg tctcaaaaaa taaaataaaa 96840
taaagttaag agagaaaaaa atatatccta tatcctttgt taaattccaa aacagtaggg 96900
gacaaataac tgacttgaca ggttactaca atatttcctg aaatgatgtt ttcttgaata 96960
ctggcctact agaggttcat aggtgtgttt ggattaaaaa agagttccat ggcccagtga 97020
ctgggggaaa aaaataaaag actaaagtaa gttaaacagg cttttctgct gcaggacttg 97080
tcagagcctt taatgtacta atggccattg tgaccctctg agaaggtcac agagtgggtt 97140
tcccaaactt acttgattct acctgctaac atttcctgga ggaagtttgg gaaatgccga 97200
tttagcagat tcttttgttg tgccgtggat ggtgctggtt gatgtgggca aaacaaagaa 97260
cacgtgagtc agatccgcct ggggctctta ctaaagtgca ggttcccagg tgccacttta 97320
ggcttacaga cccagttgtg gggtaagcct gggagtcttt tagcaggtga ttctgccaca 97380
tagtatagtt ggaaaacctc tgggcatact cattgctggt ccctctagaa atccaggtga 97440
caatagccaa tgagaagctc caagagaccc agttgtccat ggggtagagg gaatgtgata 97500
ttgaaaccaa agaagaaaat ctatgatcag ttttcagcag tgactgtcaa gagaaggaga 97560
agggtgagtt agcgctgatg ctggctgaca ggtcagcggg ttggtttcac caaggagtgt 97620
gatgaaggct gatgttgtct gtgggaatgt atgatggtaa ctggtttgta gctaatttgg 97680
ggaagcagtg agaattcgtg ccctttgaag accagtaagt ggcaagaaac ccaccaggcc 97740
tggctcaggg ctgggctggg cttggctcgt ctcagagcag ctggggctgg tggccaaagc 97800
caccattagt gaggggcagg ccctgggggt acaaccagca actaggggac aaagacaacc 97860
ctgccagcct ctcctattct ggaggcgtgt gaccagaaat ggagatgggt tggtcagcat 97920
aagatggcca ggaaggtgga aatcaggact gctggcaatc tagccacatg ggcaggggag 97980
ccgggtggtt ccaggcagtt tccaaggcca agagggtgag caggcacctc acagggaatc 98040
agggccaagc ctggctgcag tgtggagaca atgcacccac ccccatcctt ggatcttgca 98100
ggaggctggg tcctcactga gctaccaaca tccatggccc tgaggctttt aaaacaccca 98160
tccatggagt ggggctggtc ccagtggggt gaggctgacc ctggcagaaa cagggcagga 98220
gcctgtgggt tagggagact gcaccttcct tagatagcct ccatgccatc atgtccccgt 98280
gacagtttct gctgcgtccc ctctgcatgg tcccaccctc ggccagcctg ctgccccctc 98340
ttgccaggtt gcgctaatca gtgaccccag tgtgctgtgt tgatactaac aatgcgaggc 98400
ctagcagatt caagggaaaa gagaaccaac tgggtttcca ccagacccaa ctaaacaaac 98460
atggacctat cccagagaaa tccagcttca ccacagctgg ctttctgtga acagtgaaaa 98520
tggagtgtga caagcattct tattttatat tttatcagct cgcatggtca gtaaaagcaa 98580
agacgggact ggaagcgatg acaaaaaagc caaggtaagc tgacgatgcc acggagctct 98640
gcagctggtc aagtttacag agaagctgtg ctttatgtct gattcattct catatataat 98700
gtggggagta tttgtcacta aagtacagct gtcatttaaa gtgctttgta ttttggggca 98760
ggcttttaaa aagtccagca tttattagtt ttgatactta ccccagggaa gagcagttgg 98820
caggttcatg aagtcatgct cctaattcca gctttcttag tgtactttca gtgagaccct 98880
gacagtaaat gaaggtgtgt ttgaaaacca aacccaggac agtaaatgaa ggtgtgtttg 98940
aaaaccagcc ctaggacagt aaatgaagcc atcttctcac tgcataaact gcacccagat 99000
cttcgcccat ccttctcagt atttcacttc acccattgtt tactgtctca atgactgggg 99060
aaatgtctgg ggaaatgctc ccgtaattgc acagtggcgt ttttcctgga aaatcccacc 99120
atggctctag ataagaccta tttttcttaa aggtatctaa aatttccagc ataaattctg 99180
tctgaaacac ctgaatttta atcagtactg gagcccggag ggcatctcca gttgccacat 99240
agctctgagc attcagtggt gtgttgaggg ctgctcccgg aagtgcctgc agagtcaggg 99300
ctccccagcc tcatctagtg aggcagtgga agggcctgtg gggatttgga gagctggcct 99360
gggtctctga agtgatagtg acagctgctt gtcaatcacg gtgcacattt agtgctgggg 99420
gcagggggca gggaatacca gcctcatgca tgcatgcatt catttgttcc ttccttcatt 99480
cattcattca gtacacatgg gtacaacatc cctgccctgg agttgcccag agtctaggga 99540
ggggaaagat ctattaccct gggcctcggc cagctgggga gtgctgctgg tggagagggg 99600
ccgtgtgcag cgagggaagg aggagtcgtc aataccccca ccccagcttt gctttcttgt 99660
catcagcccc agggccccag cctgtgtccc tcctctccca ttgctacttc atctcctggg 99720
tcctccttac caagcctgac cacacagagg gccttggccg cttccatggg gaattggaaa 99780
gcaataagat agcatcccct agaagcccag tgaagtctgg gacaggaccc ttctctgagc 99840
tctgacttgc tcttggaaac acttcgaggc ttagcctccc cactttgttt cccgagagtg 99900
tgacctgttc ccctccaaac acccccttct cctccagggc catgcccacc cgtcaaaatc 99960
ccccacgggc aggacgaact gtgggtgtca gtcaccatct atcctgcatc ctggttccag 100020
ggcccccccc agccccgcct ccatagggac aggcgtgcag acacccgtcc ctggctgctt 100080
cctcttgtgg aatgggttca aaagtaagca gtgttgttta cactgacaaa ctgaaaaaaa 100140
aagaaaaaga gataacattg gaggcttggc acagtggctc atgcctgtaa tcccagcact 100200
ttgggaggct aaggtgggag gatgtcccca gcccaagagt tctagaccag cctgggcaac 100260
atagcaagac cccatctcaa aaaaaaaatt taattggcca ggcagaggtg ggaggatcac 100320
ttgaacccaa agggtggagg ctgcagtgag ccgtgatggc accactgcac tccagccagg 100380
gcaacagagg gagaccctgt ctctaaaaca aacaaacaaa caaacaaaca aaagagttaa 100440
cattggccag attaggattc accagatagt gttaatatta gtttgatttg agactttaat 100500
cagaaagcac atgtgtggtg ggggtgggtg taacctaagt caggtagaat ctttccaact 100560
tggggggggc acactcctga ttgtagccat atgagtctgt cagtgtggtg gaagaggcca 100620
tgggttaatg ggcaggtaaa aaagcacctt gcctggaatt gagtagaaag taaggccctt 100680
cagaccccgt gacacacttg gggacatttt cttgagtaac atcctaagat tcatgtacct 100740
tgatgatctc catcaactta ctcatgtgaa gcacctttaa accagtcgtc tccaaattca 100800
ggggcacagt aacatccaac aggctggaga aagaacgtac tagaacttcc attccttttt 100860
catgtcctct tctaaaagct ttgtcagggc caggcgcggt ggctcacgcc tgtaatccca 100920
gcactttggg aggccgagac gggtggatca cgaggtcagg agatcgagac catcctggct 100980
aacacagtga aaccccatct ctactaaaaa tacaaaaaaa cgagccgggc gtggtggtgg 101040
gcgcctgtag tcccagctac tcgggaggct gaggcaggag aatggcgtga acccaggagg 101100
cagagcttgc agtgagccga gattgcacca ctgcagtcca gcctgggcga cagagcgaga 101160
ctccgtctca aaaaagaaaa agaaaaagaa aaagaactgt gattggggag gacggtcact 101220
ttcctgttct tactgatcag aagggatatt aagggtacct gattcaaaca gcctggagat 101280
cactgctttc aaccattacc tgccttattt atttttagtt actgtccttt tttcagtttg 101340
tttccctcct ccatgtgctg acttttattt tgattttatt tatgtttatg tttaagacat 101400
ccacacgttc ctctgctaaa accttgaaaa ataggccttg ccttagcccc aaacacccca 101460
ctcctggtag ctcagaccct ctgatccaac cctccagccc tgctgtgtgc ccagagccac 101520
cttcctctcc taaatacgtc tcttctgtca cttcccgaac tggcagttct ggagcaaagg 101580
agatgaaact caaggtaagg aaaccacctt tgaaaagaac caggctgctc tgctgtggtt 101640
tgcaaatgtg gggtttgttt atttgttttt tagcctcaaa gacctttctt caaatgagtt 101700
ctggcataga agcaccgtgt aaaatagtta gaattctggg caaaggggaa aagagagctg 101760
ggggccatcc ctctcagcac cccacaggct ctcatagcag cagctcctaa gacacctggt 101820
gggaccttgg tttcgaaatc gctactctaa ggctgggcac ggtggctcac acctgtaatc 101880
ccagctcttt aggaggccga ggagggtgga tcacctgaga tcaggagttc gagaccagcc 101940
tggctaacat ggcaaaaccc tgtctctact aaaaatacaa aaattagccg ggcgtggtgg 102000
tatgcgtggt ggtaatcgca gctactcggg aggctgaggc acaaggattg cttgaacccc 102060
agaggcagag gttgtagtta gctccagctt gggcgacaga gcaagaccct gtcgcaaaaa 102120
ttgtttaaaa aacaaaccca aaattgctac tctcattggg ttcctttgcc cattcctgat 102180
tttggcaaga gaaatgcttc cagattgccc tgatctgggt aggacagcat cacgccatag 102240
caacactgcc ccgtgagctc actgccccct caactagctt gtggtccttg gttaatgtca 102300
gtttcttttt tgagtttgtg ttatgtctaa gggtcatctg ctgggtaacg gaacccaggg 102360
actgccctag tccctagact gtgccatgcc cgactctgcc agctttgtca gtgatgctgg 102420
tgctcgcctc ctcgggtgct cgcctggtct gagcacaccc aaggagttct tgaggcctta 102480
gggttgtttg cgagagaatg aaagaacacg acctagctct ctttagcatc cttggtcagg 102540
ttcaacactg cccccagggg cctctggtgg agccaaccac catcagccaa ataaatccat 102600
aattagagtc agaaaatgga tgtctgcata tgtgtagtgc actaatgtcc tgccgatgat 102660
tgacatggag tggagagtga cctgatcatt gctgtgagct ctgctggcct tggcacaact 102720
catgctgata actaatgcac acagttcctc tgggaggaaa tgtcctcagg gaacttggag 102780
tttgggtggg gatgtgggtt tgtgtgccca gcaagccctt gtggttgtag cagacactag 102840
tggcatctag gaggcaaagg gtcaccccag tcttagccac gttttgagtc aaggtggcgg 102900
agtggggctg gtgttgactc ttggtggcag taacttttcc caatggtgaa aaacccctct 102960
atcatgtttc atttacaggg ggctgatggt aaaacgaaga tcgccacacc gcggggagca 103020
gcccctccag gccagaaggg ccaggccaac gccaccagga ttccagcaaa aaccccgccc 103080
gctccaaaga caccacccag ctctggtaag aagaacgttc tcttgaatct tagaggaagc 103140
tgaagctctc agaggtacag ccttcatttt aggaggcctt aggccactga gaatgaataa 103200
cccctggcag ctggtcagca gcttgcagtt tactaagcac tggagtcttc attgccttct 103260
cagtcctttt gatttctgag gcaaatgttg aatccctacc tttttttttt tttttctttt 103320
gagacagagt ttcgcttttg ttatccaggc cggagtgcag tggtgtgatc tcagctcact 103380
gcatcctcca cctcccaggt tcaagcgatt ctcctacctc agcctcccta gtagctggga 103440
ttacaggcac ctgccactat gcccggctaa ttttttgtat ttttagtaga gacagggttt 103500
caccatgttg gccaggctgg tctcgaacgc ctgacctcag gtgatccacc tgcctcggcc 103560
tcccaaagtg ctgggattac aggcatgagc caccactccc agcctgaatc ctcacttttt 103620
atcaatgaag aaattgaggc tgattctgca gcatgataaa aaaaaataca gaaaaaggaa 103680
aaaaaagaaa gaaatcgagc ctctgagagt ttgcttgact gagtctaacc agctcatttt 103740
aaacccgagg aaaatgcagt cacatgacta ctaagtggca gctctcggag cctctctggc 103800
cccaagtcca gggttccata gaggcagccc cagcatggca tgttttcagt ccccaaatga 103860
gactctggag acaaatgtct ctggagacag agcagcagcc tggataagtc acaatgggtg 103920
acgtcactca gggctcaacc cctgggcagc ttaacttgct agggacgtta ggagtctgct 103980
gcaaaacctg agggtcttag ctgagcagtc acaggctggg cccgttgccc tgggctcctg 104040
tgagtaaaac ccagtcaatt ttgagtaccc agtaaggcat ccattgagtt attttgcagc 104100
caggagtgct attaagaaca gtcgcggctg ggcgtggtgg ctcatgcctg taatcccagc 104160
actttgggag gccaaggtgg gcggatcacc tgaggtcagg agttcgagac cagcttggcc 104220
aacatggcaa aaccccgtct ctaataaaaa tacaaaataa ttagctgggc gtggtggcgg 104280
gcgcctgtaa tcccagcttc tcaggagggt gaggaaggag aatcacttga acccaggagg 104340
cagaggttgc agtgagctga gatcgcacca ttgcactcca gcctggatga caaaagtgag 104400
attccttctc aaaaaaaaaa aaaaaaaaac agtcgtcctc tttggggatt agggacagcc 104460
tgcctgcctg cccgagcact tctctcttcc attgccccag tgaagtattc caggcccctg 104520
ggtttagact ctgcaccatg taggggtgtc tgacctgcac ttgctccttg gtggcacggg 104580
cagcctatgg cacttgctgc gggctgtgac caaagcctgg cctggatctt ggatcttggt 104640
gactctgctt ctccctggcc tgagggagct gcccagagcc tgcccaccac ctgctgcgtg 104700
tctttgcggt ggcatttctc gcacacatgc cgtgcagtgg cacccccaag gatggccatt 104760
cactaaggcc cattgttttt gtcttttcgc ttcgtgtttt ctggcctggt gtttttctca 104820
tatacatgtg atccagggat aattcccaga attttgacag gattttaagt agcgtttgga 104880
tcctgctgtt tttttttcac ttaacatcgg gccagttgac tcacactctg ttttttgttg 104940
ttgttttttt gagacggagt ctcactgtgt cacccaggct gaagtgcagt ggcacaatct 105000
tggcatactg caacctctgc ttcccaaatt caagcagttt tcctgcctca gcctcctgag 105060
tagctgggac tacaggcaca ggccaccacg ccctgctaat ttttgtattt ttagtaaaga 105120
cagggtttca ccattttggc cagcctagtc tcgaactcct gacctcaagt gatccgccca 105180
cctcggcctc ccaaagtgct gggattacag gggactcaca ctttgtaaca acctgaaaca 105240
acgtgatgca tttccctttg ggtcttacct gctcttcggt ggctgcctgc aggtggagag 105300
accctccccc ttgggcccct cgaccttgtt tcagaatggg gcccctgctg ggccagctgt 105360
gggtgcctgc cacgtgaagg actcattaag gccctgttta agcctgatga taataaggct 105420
ttcgtggatt tttctcttta agcgactaag caagtccaga gaagaccacc ccctgcaggg 105480
cccagatctg agagaggtac tcgggagcct acttcgctgg gagcagcctc cctttgcgtg 105540
tgtggccatt cactggcttg tgtttctaga gccgggagga cccttttctg caatgcaggg 105600
ttcacacagg gttcgcagcc tgaagatgga gcagtccgaa ttctcttccc tgtgcagttt 105660
gcgcagctgt gtttgtctga tgggctttct aatcctgtgt gctctccttg acttcaggga 105720
caatggcatt acaggcatga gccaccatgc ctggctgtct ccctatgttt cagatgaaga 105780
cataggctta aggaggtcag gtgacttgcc cacgaccact ctgtaaataa gaggcatgaa 105840
aagtatttgg agccaccacc accaagccca ctggtcaccc tgggtctctg aagtcaggga 105900
ggcaggagga tgggaggtct gaggaggcag agaggctgag cctggaggcc ctggaggccg 105960
aggccccatc tgttgtttcc ttatgtggaa aataagaggc ttcgtttgtc ctattgccac 106020
agagcgtact acttcaggaa catccaagac atggaaatcc gcagggcacg gtggctcacg 106080
tctataatcc cggcactttg ggaggttgag gtgggagaat cgcttgaggc cagaagttca 106140
agaccagcct gagcaacata gtcagacccc gtctctataa aaaacattat ttttaaaaaa 106200
gacatggaag tcaaattcta aaaactggtg ctggctgggt gcggtggctc atgcctataa 106260
tcccagcact ttgggaggcc gaggcgggtg gatcacctga ggtcaggagt tcaagaccag 106320
cctggccaac atggtaaaac ctctactaaa gaaatcttta ctgaaaatac aaaaatccag 106380
tctctactaa aataagtctc tactaaaaat acaaaaatta gccaggcgtg gtgctgcaca 106440
cctgtaatat cagctactcg ggaggctgag gcaggagact cgcttgatcc catgcagcgg 106500
aggttgcagt gagccgagat cacgccattg cactccagcc tgggcatcag aataagactc 106560
cgtctcaaaa aaaaaaccac aaaaaaacaa aacaacaaca aaagaaaact agtgcttatt 106620
cgtcactggc caagctgccc attggctaca tgggtgcttc aaagagctgc ccttctccag 106680
gtctggccag caggtatgtg ttacagcaaa tgcctggggc agcggcaggg gcattgctgc 106740
gggaagcttc tggacttgca ggaaagctaa gttctcagac tgcaggggag ctaagcacac 106800
ctcggcacag ggtgaggcct gcggttctca gacttcagtc tttgtggagc ttgagaaaaa 106860
tgaggctttg caggtcccac ccctagagat tctgctctat ccactcttga aggggatcga 106920
gaaatttgca ttttgcaact cccactttcc tccttgaaag ctccggagat tctgacgcag 106980
ggttccgtgg gccacacttt ggaaaataca gacccatgag atagaatacc agactgttga 107040
agtgtaacgg gggcctggga agtgcagtaa cagaagcaag tttgagggta aaggacaccc 107100
agaggaggga gggacagcat ctgcatggag aggagaagag accccccagc agcttccagg 107160
gtgttggaag ggtgcgctag taactgctat gcatggcagg tggggaactg tacgtcaggg 107220
cacagcagca tgaagcggta tggctcgtgt ggacagctag ggacaggcag gcgtggagca 107280
ggcatcctgt tctgaaggcc aaatcccaca gaggagccag ggtgctggca ggagccctga 107340
actagccgaa cagctgaaca gctgaacatt caccctgtgg ggaaagggtc agaagcgtcc 107400
aggcttgagg gcacagctgg gtctcgtcac tgcatcaccc ttatttagga taaaggccct 107460
gaagaattgt attagaggtt ggcaaagcat atctaccacc tcctggagcc acgctggccg 107520
cagggattat aattatttcc attttcaaat taaggcctct gagctcagag aggggaagtt 107580
acttgtctga ggccacacag cttgttggag cccatctctt gacccaaaga ctgtggagcc 107640
gagttggcca cctctctggg agcgggtatt ggatggtggt tgatggtttt ccattgcttt 107700
cctgggaaag gggtgtctct gtccctaagc aaaaaggcag ggaggaagag atgcttcccc 107760
agggcagccg tctgctgtag ctgcgcttcc aacctggctt ccacctgcct aacccagtgg 107820
tgagcctggg aatggaccca cgggacaggc agcccccagg gccttttctg accccaccca 107880
ctcgagtcct ggcttcactc ccttccttcc ttcccaggtg aacctccaaa atcaggggat 107940
cgcagcggct acagcagccc cggctcccca ggcactcccg gcagccgctc ccgcaccccg 108000
tcccttccaa ccccacccac ccgggagccc aagaaggtgg cagtggtccg tactccaccc 108060
aagtcgccgt cttccgccaa gagccgcctg cagacagccc ccgtgcccat gccagacctg 108120
aagaatgtca agtccaagat cggctccact gagaacctga agcaccagcc gggaggcggg 108180
aaggtgagag tggctggctg cgcgtggagg tgtggggggc tgcgcctgga ggggtagggc 108240
tgtgcctgga agggtagggc tgcgcctgga ggtgcgcggt tgagcgtgga gtcgtgggac 108300
tgtgcatgga ggtgtggggc tccccgcacc tgagcacccc cgcataacac cccagtcccc 108360
tctggaccct cttcaaggaa gttcagttct ttattgggct ctccactaca ctgtgagtgc 108420
cctcctcagg cgagagaacg ttctggctct tctcttgccc cttcagcccc tgttaatcgg 108480
acagagatgg cagggctgtg tctccacggc cggaggctct catagtcagg gcacccacag 108540
cggttcccca cctgccttct gggcagaata cactgccacc cataggtcag catctccact 108600
cgtgggccat ctgcttaggt tgggttcctc tggattctgg ggagattggg ggttctgttt 108660
tgatcagctg attcttctgg gagcaagtgg gtgctcgcga gctctccagc ttcctaaagg 108720
tggagaagca cagacttcgg gggcctggcc tggatccctt tccccattcc tgtccctgtg 108780
cccctcgtct gggtgcgtta gggctgacat acaaagcacc acagtgaaag aacagcagta 108840
tgcctcctca ctagccaggt gtgggcgggt gggtttcttc caaggcctct ctgtggccgt 108900
gggtagccac ctctgtcctg caccgctgca gtcttccctc tgtgtgtgct cctggtagct 108960
ctgcgcatgc tcatcttctt ataagaacac catggcagct gggcgtagtg gctcacgcct 109020
ataatcccag cactttggga ggctgaggca ggcagatcac gaggtcagga gttcgagacc 109080
aacctgacca acagggtgaa acctcgtctc tactaaaaat acaaaaatac ctgggcgtgg 109140
tggtggtgcg cgcctataat cccagctact caggaggctg aggcaggaga atcgcttgaa 109200
cccaggaggc agaggttgca gtgagccgag atagtgccac tgcactccag tttgagcaac 109260
agagcgagac tctgtctcaa aacaaaataa aacaaaccaa aaaaacccac catggcttag 109320
ggcccagcct gatgacctca tttttcactt agtcacctct ctaaaggccc tgtctccaaa 109380
tagagtcaca ttctaaggta cgggggtgtt ggggaggggg gttagggctt caacatgtga 109440
atttgcgggg accacaattc agcccaggac cccgctcccg ccacccagca ctggggagct 109500
ggggaagggt gaagaggagg ctgggggtga gaaggaccac agctcactct gaggctgcag 109560
atgtgctggg ccttctgggc actgggcctc ggggagctag ggggctttct ggaaccctgg 109620
gcctgcgtgt cagcttgcct cccccacgca ggcgctctcc acaccattga agttcttatc 109680
acttgggtct gagcctgggg catttggacg gagggtggcc accagtgcac atgggcacct 109740
tgcctcaaac cctgccacct ccccccaccc aggatccccc ctgcccccga acaagcttgt 109800
gagtgcagtg tcacatccca tcgggatgga aatggacggt cgggttaaaa gggacgcatg 109860
tgtagaccct gcctctgtgc atcaggcctc ttttgagagt ccctgcgtgc caggcggtgc 109920
acagaggtgg agaagactcg gctgtgcccc agagcacctc ctctcatcga ggaaaggaca 109980
gacagtggct cccctgtggc tgtggggaca agggcagagc tccctggaac acaggaggga 110040
gggaaggaag agaacatctc agaatctccc tcctgatggc aaacgatccg ggttaaatta 110100
aggtccggcc ttttcctgct caggcatgtg gagcttgtag tggaagaggc tctctggacc 110160
ctcatccacc acagtggcct ggttagagac cttggggaaa taactcacag gtgacccagg 110220
gcctctgtcc tgtaccgcag ctgagggaaa ctgtcctgcg cttccactgg ggacaatgcg 110280
ctccctcgtc tccagacttt ccagtcctca ttcggttctc gaaagtcgcc tccagaagcc 110340
ccatcttggg accaccgtga ctttcattct ccagggtgcc tggccttggt gctgcccaag 110400
accccagagg ggccctcact ggcctttcct gccttttctc ccattgccca cccatgcacc 110460
cccatcctgc tccagcaccc agactgccat ccaggatctc ctcaagtcac ataacaagca 110520
gcacccacaa ggtgctccct tccccctagc ctgaatctgc tgctccccgt ctggggttcc 110580
ccgcccatgc acctctgggg gcccctgggt tctgccatac cctgccctgt gtcccatggt 110640
ggggaatgtc cttctctcct tatctcttcc cttcccttaa atccaagttc agttgccatc 110700
tcctccagga agtcttcctg gattcccctc tctcttctta aagcccctgt aaactctgac 110760
cacactgagc atgtgtctgc tgctccctag tctgggccat gagtgagggt ggaggccaag 110820
tctcatgcat ttttgcagcc cccacaagac tgtgcaggtg gccggccctc attgaatgcg 110880
gggttaattt aactcagcct ctgtgtgagt ggatgattca ggttgccaga gacagaaccc 110940
tcagcttagc atgggaagta gcttccctgt tgaccctgag ttcatctgag gttggcttgg 111000
aaggtgtggg caccatttgg cccagttctt acagctctga agagagcagc aggaatgggg 111060
ctgagcaggg aagacaactt tccattgaag gcccctttca gggccagaac tgtccctccc 111120
accctgcagc tgccctgcct ctgcccatga ggggtgagag tcaggcgacc tcatgccaag 111180
tgtagaaagg ggcagatggg agccccaggt tatgacgtca ccatgctggg tggaggcagc 111240
acgtccaaat ctactaaagg gttaaaggag aaagggtgac ttgacttttc ttgagatatt 111300
ttgggggacg aagtgtggaa aagtggcaga ggacacagtc acagcctccc ttaaatgcca 111360
ggaaagccta gaaaaattgt ctgaaactaa acctcagcca taacaaagac caacacatga 111420
atctccagga aaaaagaaaa agaaaaatgt catacagggt ccatgcacaa gagcctttaa 111480
aatgacccgc tgaagggtgt caggcctcct cctcctggac tggcctgaag gctccacgag 111540
cttttgctga gacctttggg tccctgtggc ctcatgtagt acccagtatg cagtaagtgc 111600
tcaataaatg tttggctaca aaagaggcaa agctggcgga gtctgaagaa tccctcaacc 111660
gtgccggaac agatgctaac accaaaggga aaagagcagg agccaagtca cgtttgggaa 111720
cctgcagagg ctgaaaactg ccgcagattg ctgcaaatca ttgggggaaa aacggaaaac 111780
gtctgttttc ccctttgtgc ttttctctgt tttcttcttt gtgcttttct ctgttttcag 111840
gatttgctac agtgaacata gattgctttg gggccccaaa tggaattatt ttgaaaggaa 111900
aatgcagata atcaggtggc cgcactggag caccagctgg gtaggggtag agattgcagg 111960
caaggaggag gagctgggtg gggtgccagg caggaagagc ccgtaggccc cgccgatctt 112020
gtgggagtcg tgggtggcag tgttccctcc agactgtaaa agggagcacc tggcgggaag 112080
agggaattct tttaaacatc attccagtgc ccgagcctcc tggacctgtt gtcatcttga 112140
ggtgggcctc ccctgggtga ctctagtgtg cagcctggct gagactcagt ggccctgggt 112200
tcttactgct gacacctacc ctcaacctca accactgcgg cctcctgtgc accctgatcc 112260
agtggctcat tttccacttt cagtcccagc tctatcccta tttgcagttt ccaagtgcct 112320
ggtcctcagt cagctcagac ccagccaggc cagcccctgg ttcccacatc ccctttgcca 112380
agctcatccc cgccctgttt ggcctgcggg agtgggagtg tgtccagaca cagagacaaa 112440
ggaccagctt ttaaaacatt ttgttggggc caggtgtggt ggctcacacc taatcccaac 112500
acctggggag gccaaggcag aaggatcact tgagtccagg agttcaagac cagcctgggc 112560
aacataggga gaccctgtct ctacaatttt ttttttaatt agctgggcct gttggcactc 112620
tcctgtagtt ccagctactc tagaggctga ggtgggagga ctgcttgagc ctgggaggtc 112680
agggctgcaa tgagccatgt tcacaccact gaacgccagc ctgggcgaga ccctgtatca 112740
aaaaagtaaa gtaaaatgaa tcctgtacgt tatattaagg tgccccaaat tgtacttaga 112800
aggatttcat agttttaaat acttttgtta tttaaaaaat taaatgactg cagcatataa 112860
attaggttct taatggaggg gaaaaagagt acaagaaaag aaataagaat ctagaaacaa 112920
agataagagc agaaataaac cagaaaacac aaccttgcac tcctaactta aaaaaaaaaa 112980
tgaagaaaac acaaccagta aaacaacata taacagcatt aagagctggc tcctggctgg 113040
gcgcggtggc gcatgcctgt aatcccaaca ctttgggagg ccgatgctgg aggatcactt 113100
gagaccagga gttcaaggtt gcagtgagct atgatcatac cactacaccc tagcctgggc 113160
aacacagtga gactgagact ctattaaaaa aaaaatgctg gttccttcct tatttcattc 113220
ctttattcat tcattcagac aacatttatg gggcacttct gagcaccagg ctctgtgcta 113280
agagcttttg cccccagggt ccaggccagg ggacaggggc aggtgagcag agaaacaggg 113340
ccagtcacag cagcaggagg aatgtaggat ggagagcttg gccaggcaag gacatgcagg 113400
gggagcagcc tgcacaagtc agcaagccag agaagacagg cagacccttg tttgggacct 113460
gttcagtggc ctttgaaagg acagccccca cccggagtgc tgggtgcagg agctgaagga 113520
ggatagtgga acactgcaac gtggagctct tcagagcaaa agcaaaataa acaactggag 113580
gcagctgggg cagcagaggg tgtgtgttca gcactaaggg gtgtgaagct tgagcgctag 113640
gagagttcac actggcagaa gagaggttgg ggcagctgca agcctctgga catcgcccga 113700
caggacagag ggtggtggac ggtggccctg aagagaggct cagttcagct ggcagtggcc 113760
gtgggagtgc tgaagcaggc aggctgtcgg catctgctgg ggacggttaa gcaggggtga 113820
gggcccagcc tcagcagccc ttcttggggg gtcgctggga aacatagagg agaactgaag 113880
aagcagggag tcccagggtc catgcagggc gagagagaag ttgctcatgt ggggcccagg 113940
ctgcaggatc aggagaactg gggaccctgt gactgccagc ggggagaagg gggtgtgcag 114000
gatcatgccc agggaagggc ccaggggccc aagcatgggg gggcctggtt ggctctgaga 114060
agatggagct aaagtcactt tctcggagga tgtccaggcc aatagttggg atgtgaagac 114120
gtgaagcagc acagagcctg gaagcccagg atggacagaa acctacctga gcagtggggc 114180
tttgaaagcc ttggggcggg gggtgcaata ttcaagatgg ccacaagatg gcaatagaat 114240
gctgtaactt tcttggttct gggccgcagc ctgggtggct gcttccttcc ctgtgtgtat 114300
tgatttgttt ctcttttttg agacagagtc ttgctgggtt gcccaggctg gagtgcagtg 114360
gtgcgatcat agctcactgc agccttgaag tcctgagctc aagagatcct tccacctcag 114420
cctcctgagt agttgggacc acaggcttgc accacagtgc ccaactaatt tcttatattt 114480
tttgtagaga tggggtttca ctgtgtcgcc caggatggtc ttgaactcct gggctcaagt 114540
gatcctcctg cctcagcctc gcaaattgct gggattacag gtgtgagcca ccatgcccga 114600
ccttctcttt ttaagggcgt gtgtgtgtgt gtgtgtgtgt gggcgcactc tcgtcttcac 114660
cttcccccag ccttgctctg tctctaccca gtcacctctg cccatctctc cgatctgttt 114720
ctctctcctt ttacccctct ttcctccctc ctcatacacc actgaccatt atagagaact 114780
gagtattcta aaaatacatt ttatttattt attttgagac agagtctcac tctgtcaccc 114840
aggctggagt gcagtggtgc aatctcggct cactgcaacc tccgcctccc aggttgaagc 114900
aactctcctg cctcagcctc cctagtagct gggattacaa gcacacacca ccatgcctag 114960
caaattttta tatttttagt agaggagggg tgtcaccatg tttgccaagc tggtctcaaa 115020
ctcctggcct caggtgatct gcctaccttg gtctcccaaa gtgctgggat tacaggtgtg 115080
agccaccacg cctgccctta aaaatacatt atatttaata gcaaagcccc agttgtcact 115140
ttaaaaagca tctatgtaga acatttatgt ggaataaata cagtgaattt gtacgtggaa 115200
tcgtttgcct ctcctcaatc agggccaggg atgcaggtga gcttgggctg agatgtcaga 115260
ccccacagta agtggggggc agagccaggc tgggaccctc ctctaggaca gctctgtaac 115320
tctgagaccc tccaggcatc ttttcctgta cctcagtgct tctgaaaaat ctgtgtgaat 115380
caaatcattt taaaggagct tgggttcatc actgtttaaa ggacagtgta aataattctg 115440
aaggtgactc taccctgtta tttgatctct tctttggcca gctgacttaa caggacatag 115500
acaggttttc ctgtgtcagt tcctaagctg atcaccttgg acttgaagag gaggcttgtg 115560
tgggcatcca gtgcccaccc cgggttaaac tcccagcaga gtattgcact gggcttgctg 115620
agcctggtga ggcaaagcac agcacagcga gcaccaggca gtgctggaga caggccaagt 115680
ctgggccagc ctgggagcca actgtgaggc acggacgggg ctgtggggct gtggggctgc 115740
aggcttgggg ccagggaggg agggctgggc tctttggaac agccttgaga gaactgaacc 115800
caaacaaaac cagatcaagg tctagtgaga gcttagggct gctttgggtg ctccaggaaa 115860
ttgattaaac caagtggaca cacaccccca gccccacctc accacagcct ctccttcagg 115920
gtcaaactct gaccacagac atttctcccc tgactaggag ttccctggat caaaattggg 115980
agcttgcaac acatcgttct ctcccttgat ggtttttgtc agtgtctatc cagagctgaa 116040
gtgtaatata tatgttactg tagctgagaa attaaatttc aggattctga tttcataatg 116100
acaaccattc ctcttttctc tcccttctgt aaatctaaga ttctataaac ggtgttgact 116160
taatgtgaca attggcagta gttcaggtct gctttgtaaa tacccttgtg tctattgtaa 116220
aatctcacaa aggcttgttg ccttttttgt ggggttagaa caagaaaaag ccacatggaa 116280
aaaaaatttc ttttttgttt ttttgtttgc ttgttttttt gagacagagt ttcactctgt 116340
cgcccaggct ggagtgcagt ggtgcgatct ccgcccactg caagctccac ctcccgggtt 116400
catgctattc tcctgtctca gcctcccaag tagctgggac tgcaggtgcc cgccaccaca 116460
cctggctaat ttttttgtat ttttagtaga gacggggttt caccgtgtta gccaggatgg 116520
tctcaatctc ctgacctcgt catctgcctg cctcggcctc ccaaagtgct gagattacag 116580
gcgtgagcca ccgtgcccgg ccagaaaaaa acatttctaa gtatgtggca gatactgaat 116640
tattgcttaa tgtcctttga ttcatttgtt taatttcttt aatggattag tacagaaaac 116700
aaagttctct tccttgaaaa actggtaagt tttctttgtc agataaggag agttaaataa 116760
cccatgacat ttcccttttt gcctcggctt ccaggaagct caaagttaaa tgtaatgatc 116820
actcttgtaa ttatcagtgt tgatgccctt cccttcttct aatgttactc tttacatttt 116880
cctgctttat tattgtgtgt gttttctaat tctaagctgt tcccactcct ttctgaaagc 116940
aggcaaatct tctaagcctt atccactgaa aagttatgaa taaaaaatga tcgtcaagcc 117000
tacaggtgct gaggctactc cagaggctga ggccagagga ccacttgagc ccaggaattt 117060
gagacctggg ctgggcagca tagcaagact ctatctccat taaaactatt tttttttatt 117120
taaaaaataa tccgcaaaga aggagtttat gtgggattcc ttaaaatcgg agggtggcat 117180
gaattgattc aaagacttgt gcagagggcg acagtgactc cttgagaagc agtgtgagaa 117240
agcctgtccc acctccttcc gcagctccag cctgggctga ggcactgtca cagtgtctcc 117300
ttgctggcag gagagaattt caacattcac caaaaagtag tattgttttt attaggttta 117360
tgaggctgta gccttgagga cagcccagga caactttgtt gtcacataga tagcctgtgg 117420
ctacaaactc tgagatctag attcttctgt ggctgcttct gacctgagaa agttgcggaa 117480
cctcagcgag cctcacatgg cctccttgtc cttaacgtgg ggacggtggg caagaaaggt 117540
gatgtggcac tagagattta tccatctcta aaggaggagt ggattgtaca ttgaaacacc 117600
agagaaggaa ttacaaagga agaatttgag tatctaaaaa tgtaggtcag gcgctcctgt 117660
gttgattgca gggctattca caatagccaa gatttggaag caacccaagt gtccatcaac 117720
agacaaatgg ataaagaaaa tgtggtgcat atacacaatg gaatactatt cagccatgaa 117780
aaagaatgag aatctgtcat ttgaaacaac atggatggaa ctggaggaca ttatgttaag 117840
tgaaataagc cagacagaag gacagacttc acatgttctc acacatttgt gggagctaaa 117900
aattaaactc atggagatag agagtagaag gatggttacc agaggctgag gagggtggag 117960
gggagcaggg agaaagtagg gatggttaat gggtacaaaa acgtagttag catgcataga 118020
tctagtattg gatagcacag cagggtgacg acagccaaca gtaatttata gtacatttaa 118080
aaacaactaa aagagtgtaa ttggactggc taacatggtg aaaccccgtc tctactaaaa 118140
atacaaaaat tagctgggca tggtggctca cgcctgtaat cccagcactt tgggaggccg 118200
aggcgggccg atcacgaggt caggagatcg agaccatcct agctaacatg gtgaaacccc 118260
gtctctacta caaatacaaa aaaaagaaaa aattagccgg gcatggtggt gggcgcctgt 118320
agtcccagct actcgggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt 118380
gcagtgagcc gagatcgcgc cactgcactc cagcctgggc gacaaggcaa gattctatct 118440
caaaaaaata aaaataaaat aaaataaaat aataaaataa aataaaataa aataaaataa 118500
ataaaataaa ataaaatgta taattggaat gtttataaca caagaaatga taaatgcttg 118560
aggtgataga taccccattc accgtgatgt gattattgca caatgtatgt ctgtatctaa 118620
atatctcatg taccccacaa gtatatacac ctactatgta cccatataaa tttaaaatta 118680
aaaaattata aaacaaaaat aaataagtaa attaaaatgt aggctggaca ccgtggttca 118740
cgcctgtaat cccagtgctt tgtgaggctg aggtgagaga atcacttgag cccaggagtt 118800
tgagaccggc ctgggtgaca tagcgagacc ccatcatcac aaagaatttt taaaaattag 118860
ctgggcgtgg tagcacatac cggtagttcc agctacttgg gagaccgagg caggaggatt 118920
gcttgagccc aggagtttaa ggctgcagtg agctacgatg gcgccactgc attccagcct 118980
gggtgacaga gtgagagctt gtctctattt taaaaataat aaaaagaata aataaaaata 119040
aattaaaatg taaatatgtg catgttagaa aaaatacacc catcagcaaa aagggggtaa 119100
aggagcgatt tcagtcataa ttggagagat gcagaataag ccagcaatgc agtttctttt 119160
attttggtca aaaaaaataa gcaaaacaat gttgtaaaca cccagtgctg gcagcaatgt 119220
ggtgaggctg gctctctcac cagggctcac agggaaaact catgcaaccc ttttagaaag 119280
ccatgtggag agttgtaccg agaggtttta gaatatttat aactttgacc cagaaattct 119340
attctaggac tctgtgttat gaaaataacc catcatatgg aaaaagctcc tttcagaaag 119400
aggttcatgg gaggctgttt gtattttttt tttctttgca tcaaatccag ctcctgcagg 119460
actgtttgta ttattgaagt acaaagtgga atcaatacaa atgttggata gcaggggaac 119520
aatattcaca aaatggaatg ggacatagta ttaaacatag tgcttctgat gaccgtagac 119580
catagacaat gcttaggata tgatatcact tcttttgttg ttttttgtat tttgagacga 119640
agtctcattc tgtcacccag gctggagttc agtggcgcca tctcagctca ctgcaacctc 119700
catctcccgg gttcaagcta ttctccttcc tcaacctccc gagtagctgg gttgcgcacc 119760
accatgcctg gctaactttt gtatttttag tacagacggg gtttcaccac gttggccagg 119820
ctgctcttga actcctgacg tcaggtgatc caccagcctt gacctcccaa agtgctagga 119880
ttacaggagc cactgtaccc agcctaggat atgatatcac ttcttagagc aagatacaaa 119940
attgcatgtg cacaataatt ctaccaagta taggtataca ggggtagtta tatataaatg 120000
agacttcaag gaaatacaac aaaatgcaat cgtgattgtg ttagggtggt aagaaaacgg 120060
tttttgcttt gatgagctct gttttttaaa atcgttatat tttctaataa aaatacatag 120120
tcttttgaag gaacataaaa gattatgaag aaatgagtta gatattgatt cctattgaag 120180
attcagacaa gtaaaattaa ggggaaaaaa aacgggatga accagaagtc aggctggagt 120240
tccaacccca gatccgacag cccaggctga tggggcctcc agggcagtgg tttccaccca 120300
gcattctcaa aagagccact gaggtctcag tgccattttc aagatttcgg aagcggcctg 120360
ggcacggctg gtccttcact gggatcacca cttggcaatt atttacacct gagacgaata 120420
aaaaccagag tgctgagatt acaggcatgg tggcttacgc ttgtaatcgg ctttgggaag 120480
ccgaggtggg ctgattgctt gagcccagga gtttcaaact atcctggaca acatagcatg 120540
acctcgtctc tacaaaaaat acaaaaaatt tgccaggtgt ggtggcatgt gcctgtggtc 120600
ccagctactt gggaggctga agtaggagaa tcccctgagc cctgggaagt cgaggctgca 120660
ctgagccgtg atggtgtcac tgcactccag cctgggtgac aaagtgagac cctatctcac 120720
aaagaaaaaa aacaaaacaa aaaacccaaa gcacactgtt tccactgttt ccagagttcc 120780
tgagaggaaa ggtcaccggg tgaggaagac gttctcactg atctggcaga gaaaatgtcc 120840
agtttttcca actccctaaa ccatggtttt ctatttcata gttcttaggc aaattggtaa 120900
aaatcatttc tcatcaaaac gctgatattt tcacacctcc ctggtgtctg cagaaagaac 120960
cttccagaaa tgcagtcgtg ggagacccat ccaggccacc cctgcttatg gaagagctga 121020
gaaaaagccc cacgggagca tttgctcagc ttccgttacg cacctagtgg cattgtgggt 121080
gggagagggc tggtgggtgg atggaaggag aaggcacagc ccccccttgc agggacagag 121140
ccctcgtaca gaagggacac cccacatttg tcttccccac aaagcggcct gtgtcctgcc 121200
tacggggtca gggcttctca aacctggctg tgtgtcagaa tcaccagggg aacttttcaa 121260
aactagagag actgaagcca gactcctaga ttctaattct aggtcagggc taggggctga 121320
gattgtaaaa atccacaggt gattctgatg cccggcaggc ttgagaacag ccgcagggag 121380
ttctctggga atgtgccggt gggtctagcc aggtgtgagt ggagatgccg gggaacttcc 121440
tattactcac tcgtcagtgt ggccgaacac atttttcact tgacctcagg ctggtgaacg 121500
ctcccctctg gggttcaggc ctcacgatgc catccttttg tgaagtgagg acctgcaatc 121560
ccagcttcgt aaagcccgct ggaaatcact cacacttctg ggatgccttc agagcagccc 121620
tctatccctt cagctcccct gggatgtgac tcaacctccc gtcactcccc agactgcctc 121680
tgccaagtcc gaaagtggag gcatccttgc gagcaagtag gcgggtccag ggtggcgcat 121740
gtcactcatc gaaagtggag gcgtccttgc gagcaagcag gcgggtccag ggtggcgtgt 121800
cactcatcct tttttctggc taccaaaggt gcagataatt aataagaagc tggatcttag 121860
caacgtccag tccaagtgtg gctcaaagga taatatcaaa cacgtcccgg gaggcggcag 121920
tgtgagtacc ttcacacgtc ccatgcgccg tgctgtggct tgaattatta ggaagtggtg 121980
tgagtgcgta cacttgcgag acactgcata gaataaatcc ttcttgggct ctcaggatct 122040
ggctgcgacc tctgggtgaa tgtagcccgg ctccccacat tcccccacac ggtccactgt 122100
tcccagaagc cccttcctca tattctagga gggggtgtcc cagcatttct gggtccccca 122160
gcctgcgcag gctgtgtgga cagaataggg cagatgacgg accctctctc cggaccctgc 122220
ctgggaagct gagaataccc atcaaagtct ccttccactc atgcccagcc ctgtccccag 122280
gagccccata gcccattgga agttgggctg aaggtggtgg cacctgagac tgggctgccg 122340
cctcctcccc cgacacctgg gcaggttgac gttgagtggc tccactgtgg acaggtgacc 122400
cgtttgttct gatgagcgga caccaaggtc ttactgtcct gctcagctgc tgctcctaca 122460
cgttcaaggc aggagccgat tcctaagcct ccagcttatg cttagcctgc gccaccctct 122520
ggcagagact ccagatgcaa agagccaaac caaagtgcga caggtccctc tgcccagcgt 122580
tgaggtgtgg cagagaaatg ctgcttttgg cccttttaga tttggctgcc tcttgccagg 122640
agtggtggct cgtgcctgta attccagcac tttgggagac taaggcggga ggttcgcttg 122700
agcccaggag ttcaagacca gcctgggcaa caatgagacc cctgtgtcta caaaaagaat 122760
taaaattagc caggtgtggt ggcacgcacc tgtagtccca gctacttggg aggctgaggt 122820
gggaggattg cctgagtccg ggaggcggaa gttgcaagga gccatgatcg cgccactgca 122880
cttcaaccta ggcaacagag tgagactttg tctcaaaaaa caatcatata ataattttaa 122940
aataaataga tttggcttcc tctaaatgtc cccggggact ccgtgcatct tctgtggagt 123000
gtctccgtga gattcgggac tcagatcctc aagtgcaact gacccacccg ataagctgag 123060
gcttcatcat cccctggccg gtctatgtcg actgggcacc cgaggctcct ctcccaccag 123120
ctctcttggt cagctgaaag caaactgtta acaccctggg gagctggacg tatgagaccc 123180
ttggggtggg aggcgttgat ttttgagagc aatcacctgg ccctggctgg cagtaccggg 123240
acactgctgt ggctccgggg tgggctgtct ccagaaaatg cctggcctga ggcagccacc 123300
cgcatccagc ccagagggtt tattcttgca atgtgctgct gcttcctgcc ctgagcacct 123360
ggatcccggc ttctgccctg aggccccttg agtcccacag gtagcaagcg cttgccctgc 123420
ggctgctgca tggggctaac taacgcttcc tcaccagtgt ctgctaagtg tctcctctgt 123480
ctcccacgcc ctgctctcct gtccccccag tttgtctgct gtgaggggac agaagaggtg 123540
tgtgccgccc ccacccctgc ccgggccctt gttcctggga ttgctgtttt cagctgtttg 123600
agctttgatc ctggttctct ggcttcctca aagtgagctc ggccagagga ggaaggccat 123660
gtgctttctg gttgaagtca agtctggtgc cctggtggag gctgtgctgc tgaggcggag 123720
ctggggagag agtgcacacg ggctgcgtgg ccaacccctc tgggtagctg atgcccaaag 123780
acgctgcagt gcccaggaca tctgggacct ccctggggcc cgcccgtgtg tcccgcgctg 123840
tgttcatctg cgggctagcc tgtgacccgc gctgtgctcg tctgcgggct agcctgtgtc 123900
ccgcgctctg cttgtctgcg gtctagcctg tgacctggca gagagccacc agatgtcccg 123960
ggctgagcac tgccctctga gcaccttcac aggaagccct tctcctggtg agaagagatg 124020
ccagcccctg gcatctgggg gcactggatc cctggcctga gccctagcct ctccccagcc 124080
tgggggcccc ttcccagcag gctggccctg ctccttctct acctgggacc cttctgcctc 124140
ctggctggac cctggaagct ctgcagggcc tgctgtcccc ctccctgccc tccaggtatc 124200
ctgaccaccg gccctggctc ccactgccat ccactcctct cctttctggc cgttccctgg 124260
tccctgtccc agcccccctc cccctctcac gagttacctc acccaggcca gagggaagag 124320
ggaaggaggc cctggtcata ccagcacgtc ctcccacctc cctcggccct ggtccacccc 124380
ctcagtgctg gcctcagagc acagctctct ccaagccagg ccgcgcgcca tccatcctcc 124440
ctgtccccca acgtccttgc cacagatcat gtccgccctg acacacatgg gtctcagcca 124500
tctctgcccc agttaactcc ccatccataa agagcacatg ccagctgaca ccaaaataat 124560
tcgggatggt tccagtttag acctaagtgg aaggagaaac caccacctgc cctgcacctt 124620
gttttttggt gaccttgata aaccatcttc agccatgaag ccagctgtct cccaggaagc 124680
tccagggcgg tgcttcctcg ggagctgact gataggtggg aggtggctgc ccccttgcac 124740
cctcaggtga ccccacacaa ggccactgct ggaggccctg gggactccag gaatgtcaat 124800
cagtgacctg ccccccaggc cccacacagc catggctgca tagaggcctg cctccaaggg 124860
acctgtctgt ctgccactgt ggagtcccta cagcgtgccc cccacagggg agctggttct 124920
ttgactgaga tcagctggca gctcagggtc atcattccca gagggagcgg tgccctggag 124980
gccacaggcc tcctcatgtg tgtctgcgtc cgctcgagct tactgagaca ctaaatctgt 125040
tggtttctgc tgtgccacct acccaccctg ttggtgttgc tttgttccta ttgctaaaga 125100
caggaatgtc caggacactg agtgtgcagg tgcctgctgg ttctcacgtc cgagctgctg 125160
aactccgctg ggtcctgctt actgatggtc tttgctctag tgctttccag ggtccgtgga 125220
agcttttcct ggaataaagc ccacgcatcg accctcacag cgcctcccct ctttgaggcc 125280
cagcagatac cccactcctg cctttccagc aagatttttc agatgctgtg catactcatc 125340
atattgatca cttttttctt catgcctgat tgtgatctgt caatttcatg tcaggaaagg 125400
gagtgacatt tttacactta agcgtttgct gagcaaatgt ctgggtcttg cacaatgaca 125460
atgggtccct gtttttccca gaggctcttt tgttctgcag ggattgaaga cactccagtc 125520
ccacagtccc cagctcccct ggggcagggt tggcagaatt tcgacaacac atttttccac 125580
cctgactagg atgtgctcct catggcagct gggaaccact gtccaataag ggcctgggct 125640
tacacagctg cttctcattg agttacaccc ttaataaaat aatcccattt tatccttttt 125700
gtctctctgt cttcctctct ctctgccttt cctcttctct ctcctcctct ctcatctcca 125760
ggtgcaaata gtctacaaac cagttgacct gagcaaggtg acctccaagt gtggctcatt 125820
aggcaacatc catcataaac caggtagccc tgtggaaggt gagggttggg acgggagggt 125880
gcagggggtg gaggagtcct ggtgaggctg gaactgctcc agacttcaga aggggctgga 125940
aaggatattt taggtagacc tacatcaagg aaagtgttga gtgtgaaact tgcgggagcc 126000
caggaggcgt ggtggctcca gctcgctcct gcccaggcca tgctgcccaa gacaaggtga 126060
ggcgggagtg aagtgaaata aggcaggcac agaaagaaag cacatattct cggccgggcg 126120
ctgtggctca cgcctgtaat tccagcactt tgggaggcca aggtgggtgg atcatgaggt 126180
caggagattg agaccatcct ggctaacaca gtgaaacccc gtctctacta aaaatacaaa 126240
aaattagccg ggcgtggtgg tgggcgcctg tagtcccagc tactccggag gctgaggcag 126300
gaaaatggcg tgaacccgga aggcggagct tgcagtgagc ggagtgagca gagatcgcgc 126360
cactgcactc cagcctgggc gacagagcga gactccgtct caaaaaaaaa aagcacatgt 126420
tctcgcttct ttgtgggatc caggagatag agaatagaag gatggttacc agaggctggg 126480
aagggtagtg aggggatggt ggggggatgg tcaatgggta caaaaaaaat agaataagac 126540
ctagtatttg atagtgcaac agggtgacta tagtcaataa taatttaatt gtacatttaa 126600
aaataactaa aagatagccg ggtgcagtgg cttacgtctg taatcccagt actttgggag 126660
gctgaggtgg gcgtttgaga ccagcctggc caacatggtg aaaccccatc tctactaaaa 126720
atacaaaaat tagccaggca tggtggcggg cgcctgtaat cccagctact cgggaggctg 126780
aggcaggaga atcacttgaa cctgggaggc agaggttgca gtgagccgag atcttgccac 126840
tgcactccag cctgggtgac agtgaaactc cgtctcaaaa ataaaaataa aaatacagct 126900
gggcacggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg agcggatcac 126960
aaggtcagga gatatagacc atcctggcta acacggtgaa acccggtctc tactaaaaat 127020
acaaaaaatt agccaggcgt ggtggcaggt gcctatagtc ccagctactc acaaggctga 127080
ggcaggagaa tggcatgaac ctgggaggcg gagcttgcag tgagccgaga ttgtgccact 127140
gcactccagc ctgggcgaga gagtgagact ccgtctcaaa acaaaaacaa aaacaaaaac 127200
aaaaacaaac acacaacaaa aacctaaaag aatataaatg gattgtttgt aacacaaagg 127260
acaaatgttt gaggggatgg ataccccatt ttccatgatg tgattattat acattgtgtg 127320
tctgtatcaa aacatctcat gagccccata aatatataca cctaactatg tacccacaaa 127380
aattaaaaaa atatattttt taaggtgaag agggaggcga gatgctggcc ttaaccccta 127440
acccgttgtt ctccctgcaa gctgtccaca gggcctctca gactcgaggt tcagctatat 127500
ggatgcatga gcttggtccc cagccaacat gggagacact tcaccatcgg cagcagctac 127560
agcacaggaa ccctgggtca ctgccatgtc ccctctgtga ctttgtttaa acagaaaatg 127620
atgctctggg ccggctgtgg tggcccacac ctataatccc agcaccttgg gaggcggggg 127680
tgggcagatt gcctgaggtc aggagttgga gatcagcctg gccgacatgg cgaaacccca 127740
tgtctactaa aaatacaaaa actagccagg catggtggca catgcctgta atcccagcta 127800
cttgggaggc tgaagcagga gaatcacttg aacccaggag gcagaggctg agtgagccaa 127860
gatcgtgcca atgcactcca gcttgggtga gggagtgaga ctccgtctca aaaaaaaaaa 127920
aaaagaaaga aaaagaaaag aaagtgatcc tactggaacc atgcttactc ccctccccac 127980
ctcacactgt gtagaaatta gtgctgtcgg ccaggcgcgg tggctcatgc ctgtaatcgc 128040
agcactttgg gaggccaagg caggcggatc acgaggtcag gagatcaaga ccatcctggc 128100
taacacagtg aaaccctgtc tctactaaaa atacaaaaaa ttagccgggc atggtggcag 128160
gcacctgtag tcccaactac ttgggaggct gaggcaggag aatggcatga acctgggagg 128220
cggagcttgc agtgagccaa gatcgcgcca ctgcatacca gcctaggtga cagagtgaga 128280
ctcagcaaaa aaagaaagaa agaaagaaag aaatcagtgc tgtctatact tctttctgca 128340
gtgatggaaa tattctgtat ctgtgctgtc cagtatagta gccactagct acatgtggca 128400
cttgaaacat ggctggtaca gttgaggaag agtggctgcc atatcggacg acacagctat 128460
agattctgtc accccacccc gagagtccag agcggggact tctgccttag gccctattca 128520
gggctgattt ttacttgaac ccttactgtg ggaagagaag gccatgagaa gttcagtcta 128580
gaatgtgact ccttattttc tggctccctt ggacactttg tgggatttag tctccctgtg 128640
gaaagtattc cacaagtggt gccaccaccc cagctgtgag agcagctggg agctgctttt 128700
gtcatctttc cctggaaagt cctgtgggct gtctcttcct catgccttgt cccatgcttg 128760
ggcatggtgt caagcgtcag gagggagaaa gggtccttat ttatttattt agagagggac 128820
ccttcttctg ttcccaggct ggagtgcagt ggtgcgatct cggctcactg caacctccgc 128880
ctcctgggtt caagtgattc tcctgcctca gcctcctgag tagctgagat tacaggcaca 128940
tgccaacatg cctggctaat tttttttttt tttttttttt tttttttttg agatggagtt 129000
gtactctcat tgcccaggct ggaatgtaat ggcacaatct cggctcactg caacctccac 129060
ctcctggatt caagcaattc tcctgtctca gcttcccaag tagctgggat tacaggtgcc 129120
cgccaccatg ctcaactaat ttttgtattt tttttttagt agagacgagg tttcaccatg 129180
ttggtcagac tggtctcaaa ctcctgacct caggtgatcc acctgcctcg gcctcccaaa 129240
gtgctaggat tacaggcatg agccaccacg cccggcctga aagggttctt atttagtgtg 129300
cattttgaca ttcaatttaa ttccaaggtc ttgtggggtc atggtttaca ggatgttgat 129360
atagaaaaga cttcacttaa tgggccgggc gcagtggctc atgcctgtaa tcccagcact 129420
ttgggaggcc gaggcaggca gatcaggagg tcaggagatt gagaccatcc tggctaacac 129480
agtgaaaccc catctctact gaaaatacaa aaaattagct gggcgtggtg gcaggcacct 129540
gtagtcccag ccactcggtt ggctgaggca ggagaatggc atgaacccgg gaggcggagc 129600
ttgcagtgag cagagaccat gccactgcac tccagcctgg gcgacagagc aagactctgt 129660
ctcaagaaaa aaaaaaaaaa aacagacttt acttactgga agccaaccaa tgtatattta 129720
gagtaatttt tcctgggctg agctgtcatt tacttttgca gtatctcaag aagaagagtt 129780
tacagtgtaa atatttgatg cacactttga ttatatagat gaagcaaact attttcaaga 129840
gctttgcaag gacttacttg tatccaaaca ccattctaaa ggagtcttac ctacttctaa 129900
aggctggtct ctacttggaa ccacttgctt ggccctggtt caagtcctgc tgcaaacctg 129960
gaagtcctgt cattgtcttc ttccctccag agcagtggca cccaatctaa tttttgctgt 130020
gccccagcag cccctggcac tttgccctgt agactgcaga cctcatgtaa tgtatgttaa 130080
gtccacagaa ccacagaaga tgatggcaag atgctcttgt gtgtgttgtg ttctaggagg 130140
tggccaggtg gaagtaaaat ctgagaagct tgacttcaag gacagagtcc agtcgaagat 130200
tgggtccctg gacaatatca cccacgtccc tggcggagga aataaaaagg taaagggggt 130260
agggtgggtt ggatgctgcc cttgggtata tgggcattaa tcaagttgag tggacaaagg 130320
ctggtccagt tcccagagga ggaaaacaga ggcttctgtg ttgactggct ggatgtgggc 130380
cctcagcagc atccagtggg tctccactgc ctgtctcaat cacctggagc tttagcacgt 130440
ttcacacctg ggccccaacc tggagaggct gaccaatggg tctcaggggc agctcggttg 130500
ctggagtttt tgtttttatt tatttttatg tatttaaggc agggtctctg tattagtcca 130560
ttctcacact gctaataaag acatacccaa gactgggtaa tttataaagg aaagaggttt 130620
aatggactca cagttccaca tggctgggga ggcctcaaaa tcatggcgga aggcaaagga 130680
gaagcaaagg catttcttac atggcgacag gcaagagagc gtgtgcaggg gaactcccat 130740
ttataaaacc atcagacctc atgagattta ttcactatca tgagaacagc atgggaaaga 130800
cccgccccca tgattcagtt acctcccact gggtccctcc catgacacat ggaattatgg 130860
gagctacaat tcaagatgag atttgggtgg ggacacagcc aaaccatatc agtctccctc 130920
tgtcatccag gctggagtgc actggcatga tctcggctca ctgcagcctc tacctccctg 130980
ggtcaggtga tcttcccacc tcagcctccc aggtagctgg aactacaggt acctgccact 131040
atgcctggct aaatattttg tatttcctgt ggagacgagg ttttgccacg ttgcccaggc 131100
tggtcttgaa ctcctgaggt caagcaatat gcccacctcg gcctcccaag gtgctgggat 131160
tacaggtgtg agccacagtg ctcggcctaa gtcactgcag tttttaaagc tcccaggtga 131220
ttcttcagtg cagtcaaaag tgagaactgg ctgggtgcgg tggctcatgc ctgtaatccc 131280
agcaccttgg gaggcgaagg tgggcagatg gcttgaggtc aggagttcaa gaccagcctg 131340
gccaacatgg taaaacccca tctctactaa aaatacaaaa gttagctggg tgtggtggtg 131400
cgtgcctgta atcccagcta cttgggaggc tgaggcatga gaattgcttg aacccagggg 131460
acagaggttg tagtgagccg agatcgtgcc actgcactcc agcctgggca acagagtgag 131520
attccatctc acaaaaaaaa aaaaaaaagc gagaaccact gtcctaggcc ctgatgtttg 131580
caggcaacta aaaaaggaag tggacatccc cagtcagctg tggcgcacca agaacaagtc 131640
atgggaacat aacctaattt tctaaatggg ttactaggca cttagagcaa aacaatgatg 131700
ccgaaatcct gatttcagca aagcctctgc ctgcctgtct tggaagtatc cacatgaggc 131760
tgctggggcc ttggtgtccc cagcagtttc tagtctctag gtcttgctgt gggtgtctgt 131820
gcagtgaggg tgtgtgtggc gctgggtgag ctctgtctag gcctggcaca ggatgcggtc 131880
tggtagctgc tgcttctctt ctgcagaagc gcagccaagc accctctggg gtttcaggcc 131940
cacacccagc ctgaagttct gggagtggct cactttccaa ccttcagggt ctcccagcag 132000
ctgactgggg agtggtggag ggaaaaggga ttgtattagt ccgttttcac gccgctgatg 132060
aagacatacc cgatactggg cagtctaaaa gatagaggtc tgatggactc acagttccac 132120
gtgactgggg aggcctgaca atcatggtgg aaggtgaaag gcttgtctca cacggtggca 132180
gacaagagaa aagagcttgt gcaggggaac tcccctttat aaaaccatca gatctcggga 132240
gacttattca ctatcatgag aacagcacgg gaaagaccct cctctatgat tcaattacct 132300
cccaccaggt ccctcccaca acatgtagga attgtgggaa ctacaattca agatgacatt 132360
tgggtgggga cacagccaaa ccatatcagg gcgtcccaga aagggtatag ggtctgagac 132420
ccaagtcagc atgagaaagt atgcttctca tggtggccca gttgggtgga agtggcagcc 132480
gggccgtctt tccaccaggc cactcaagta gcagctgaga gacccctgcc ctggccagtc 132540
cccgccctcc cctcttgcca ctgcctctgg ttctgaacag atgggcaccc tcatcttgta 132600
tttgtgatta atgtctaaca atgtagtttt gtgagaaggg tttgctgata cagccttgct 132660
gcagatgctg cgaactgtgg cctggggcag accttacctc cagacacgcc ctgaggcagg 132720
ggagggcact ggcccgtagc tggccgagag ctctcgggtt gcgcgacagg gatacttttc 132780
agcggctggg tcgctatcca aagtgagaaa acgaggaggg accaggaggc tgtccgcctc 132840
aagagatgtg ggggccaggt ccagttatct ggggaagcag taagcttctc tgctgtttct 132900
aaccccaggc ctcccctggt ctaaggcagg gcctcccagc ctcggggcac tttaaagata 132960
tctgggcctg gccccatccc cacagtctga ctgagtgggt ctggataggg cctgagcatt 133020
ggtgatttcc tgggtgaaag gaggcccctc acagtctctg gaagcttctc tgtgttagga 133080
aaagctctgg gcttgactct gctttgaaag tcaagatccg caaatcctct cagcctcagt 133140
ttctccttca gcaagatgaa atggaaatgc tgtacctacg tcccggggtg gttgtgagac 133200
ccaaaaaaga caatgttctg gaaggttcct ggtgcgttgc agtcctctaa gaacctgagt 133260
tagagccacg ctgagtctca gcttcttggc tccttctgtt tcaaactcgt ccatgtgata 133320
gctcaggaag ggtaggcagg gccctgcccc ctactcagaa aacaccatcc tggtcctggg 133380
gatccccgca gcattagtcc cctgttttcc cagtgtattg agaaaaattg ctaacaagca 133440
gtggggcaca ccaccagcct cctgggttcc tttcagtttg gggatttttg gacattccca 133500
ggaatgtctt aaaaaacact tcaaaaaaca ttaacataaa tatttttatc aaagcctgta 133560
ttaaatggtc tttcaagaaa atacagtaac aggtcaggca tggtggctca tgcctgtaac 133620
cccagcactt tgggaggcca aggcaggcag atcacctgaa atcaggagtt caagaccaac 133680
ctggccaaca cagccaaatc ccatctctac aaaaaataca aaaattagct gggtgtggtg 133740
gcacacacct gtagtcccag ctacttggga ggccgaggca ggagaattgc ttgatcccgg 133800
aggcggaggt tgcagtgagc tgagatcgtg ccactgcact ccagcgtggg tgacaaggtg 133860
aatctttgtc tcaaaaaaaa aaaaaaaaaa aagataaaat acagtataca gtaatagaga 133920
acaatccttt tttcaaagta gtgaccccaa atgaacaaaa tatgcatcta gcttaaatgc 133980
gaacctggtt ttctctacgc ccattcaagc ccctgcaata ggggcccttc accccgcatc 134040
catggactcc taaaattata tggaaaatgg ctgtgtgtga gtgtggatgg acatgtgcac 134100
acatattttt ggctttacca gatgctcaaa gagcctagga cccaaaaagg gctgagaatg 134160
accgtgtcgg ccacttcagg gtcatcagga attgctgtgc actgctcact tctccagtga 134220
acactttctg cttctgtgtt tcctggtatc ctttgggact cctggctagg tcatgtgttt 134280
ctctactttc aaaagggctt cagccaggca cgatggcatg agcctgtagt cccagttgct 134340
ctggaggtta aggtgggaag attgcttgag cccaggaatt tgaggccagc ctgggcaagt 134400
agataggtag atgattgata gatagataga tagataaata gatggataga taagtcgcta 134460
gacagtcatc catccaccca tccacacata aaaaggcctt tgtcatgtca tgttttgtgg 134520
cccacctgcc agtgttgccc acagttgctg cccctccaaa ctcatcagtc actggcaaac 134580
aggaggaatg tgtggctcat gtctgggcat cagtggctgt gggagacatc cttgatcttc 134640
tccagcttct ccttccacat tttcctttgc aatctggcaa tatctattaa aataaaatgt 134700
gcatgccttt tgacctaaga gcttcacttc taggacccac ttacacgtgt gtgacatgat 134760
gttcatacgg gtttatttat ctgaggttgt tcatacacac cattgcctgt aatcactaaa 134820
ggcgggagca gcctacacat ccatccacag aggagtagat gccttttggt acatccgtgg 134880
cgacggaata ctaagcagcc tgtgtatcta tacactcaca cgtgtttgtt tatgtgtgga 134940
atatctctgg agggtacaca agaaacttaa aatgatcact gtctctgggg agggtacctg 135000
ggtgcctggg aggcaggtca gggaaggagt gggcacaggt attaccaatt ggaagacaat 135060
aaaaacaaca gctcctggcc aggcgcagtg gctcacgcct gtaatggcag cactctgaga 135120
ggctgaggcg ggcagattgc ttgcgtccag gagttcaaga ccagcctggg caacatagca 135180
aaaccccgtt tctattaaaa atacaaaaaa ttagccaggt gtggtggcat gcacctgtaa 135240
tcccagctac tcgggaggct gaggtgggag aatcacctga gcctgggagg tcaaggctgc 135300
agtgaggtga gattgtgcca ccgcactcta gcctgggcga tagagcaaga ccctgtctca 135360
aaaacaaaca aaaaacagtc cctggcactc tgggccaggc ctggcagggc agttggcagg 135420
gctggtcttt ctctggcact tcatctcacc ctccctccct tcctcttctt gcagattgaa 135480
acccacaagc tgaccttccg cgagaacgcc aaagccaaga cagaccacgg ggcggagatc 135540
gtgtacaagt cgccagtggt gtctggggac acgtctccac ggcatctcag caatgtctcc 135600
tccaccggca gcatcgacat ggtagactcg ccccagctcg ccacgctagc tgacgaggtg 135660
tctgcctccc tggccaagca gggtttgtga tcaggcccct ggggcggtca ataattgtgg 135720
agaggagaga atgagagagt gtggaaaaaa aaagaataat gacccggccc ccgccctctg 135780
cccccagctg ctcctcgcag ttcggttaat tggttaatca cttaacctgc ttttgtcact 135840
cggctttggc tcgggacttc aaaatcagtg atgggagtaa gagcaaattt catctttcca 135900
aattgatggg tgggctagta ataaaatatt taaaaaaaaa cattcaaaaa catggccaca 135960
tccaacattt cctcaggcaa ttccttttga ttcttttttc ttccccctcc atgtagaaga 136020
gggagaagga gaggctctga aagctgcttc tgggggattt caagggactg ggggtgccaa 136080
ccacctctgg ccctgttgtg ggggtgtcac agaggcagtg gcagcaacaa aggatttgaa 136140
acttggtgtg ttcgtggagc cacaggcaga cgatgtcaac cttgtgtgag tgtgacgggg 136200
gttggggtgg ggcgggaggc cacgggggag gccgaggcag gggctgggca gaggggagag 136260
gaagcacaag aagtgggagt gggagaggaa gccacgtgct ggagagtaga catccccctc 136320
cttgccgctg ggagagccaa ggcctatgcc acctgcagcg tctgagcggc cgcctgtcct 136380
tggtggccgg gggtgggggc ctgctgtggg tcagtgtgcc accctctgca gggcagcctg 136440
tgggagaagg gacagcgggt aaaaagagaa ggcaagctgg caggagggtg gcacttcgtg 136500
gatgacctcc ttagaaaaga ctgaccttga tgtcttgaga gcgctggcct cttcctccct 136560
ccctgcaggg tagggggcct gagttgaggg gcttccctct gctccacaga aaccctgttt 136620
tattgagttc tgaaggttgg aactgctgcc atgattttgg ccactttgca gacctgggac 136680
tttagggcta accagttctc tttgtaagga cttgtgcctc ttgggagacg tccacccgtt 136740
tccaagcctg ggccactggc atctctggag tgtgtggggg tctgggaggc aggtcccgag 136800
ccccctgtcc ttcccacggc cactgcagtc accccgtctg cgccgctgtg ctgttgtctg 136860
ccgtgagagc ccaatcactg cctatacccc tcatcacacg tcacaatgtc ccgaattccc 136920
agcctcacca ccccttctca gtaatgaccc tggttggttg caggaggtac ctactccata 136980
ctgagggtga aattaaggga aggcaaagtc caggcacaag agtgggaccc cagcctctca 137040
ctctcagttc cactcatcca actgggaccc tcaccacgaa tctcatgatc tgattcggtt 137100
ccctgtctcc tcctcccgtc acagatgtga gccagggcac tgctcagctg tgaccctagg 137160
tgtttctgcc ttgttgacat ggagagagcc ctttcccctg agaaggcctg gccccttcct 137220
gtgctgagcc cacagcagca ggctgggtgt cttggttgtc agtggtggca ccaggatgga 137280
agggcaaggc acccagggca ggcccacagt cccgctgtcc cccacttgca ccctagcttg 137340
tagctgccaa cctcccagac agcccagccc gctgctcagc tccacatgca tagtatcagc 137400
cctccacacc cgacaaaggg gaacacaccc ccttggaaat ggttcttttc ccccagtccc 137460
agctggaagc catgctgtct gttctgctgg agcagctgaa catatacata gatgttgccc 137520
tgccctcccc atctgcaccc tgttgagttg tagttggatt tgtctgttta tgcttggatt 137580
caccagagtg actatgatag tgaaaagaaa aaaaaaaaaa aaaaaggacg catgtatctt 137640
gaaatgcttg taaagaggtt tctaacccac cctcacgagg tgtctctcac ccccacactg 137700
ggactcgtgt ggcctgtgtg gtgccaccct gctggggcct cccaagtttt gaaaggcttt 137760
cctcagcacc tgggacccaa cagagaccag cttctagcag ctaaggaggc cgttcagctg 137820
tgacgaaggc ctgaagcaca ggattaggac tgaagcgatg atgtcccctt ccctacttcc 137880
ccttggggct ccctgtgtca gggcacagac taggtcttgt ggctggtctg gcttgcggcg 137940
cgaggatggt tctctctggt catagcccga agtctcatgg cagtcccaaa ggaggcttac 138000
aactcctgca tcacaagaaa aaggaagcca ctgccagctg gggggatctg cagctcccag 138060
aagctccgtg agcctcagcc acccctcaga ctgggttcct ctccaagctc gccctctgga 138120
ggggcagcgc agcctcccac caagggccct gcgaccacag cagggattgg gatgaattgc 138180
ctgtcctgga tctgctctag aggcccaagc tgcctgcctg aggaaggatg acttgacaag 138240
tcaggagaca ctgttcccaa agccttgacc agagcacctc agcccgctga ccttgcacaa 138300
actccatctg ctgccatgag aaaagggaag ccgcctttgc aaaacattgc tgcctaaaga 138360
aactcagcag cctcaggccc aattctgcca cttctggttt gggtacagtt aaaggcaacc 138420
ctgagggact tggcagtaga aatccagggc ctcccctggg gctggcagct tcgtgtgcag 138480
ctagagcttt acctgaaagg aagtctctgg gcccagaact ctccaccaag agcctccctg 138540
ccgttcgctg agtcccagca attctcctaa gttgaaggga tctgagaagg agaaggaaat 138600
gtggggtaga tttggtggtg gttagagata tgcccccctc attactgcca acagtttcgg 138660
ctgcatttct tcacgcacct cggttcctct tcctgaagtt cttgtgccct gctcttcagc 138720
accatgggcc ttcttatacg gaaggctctg ggatctcccc cttgtggggc aggctcttgg 138780
ggccagccta agatcatggt ttagggtgat cagtgctggc agataaattg aaaaggcacg 138840
ctggcttgtg atcttaaatg aggacaatcc ccccagggct gggcactcct cccctcccct 138900
cacttctccc acctgcagag ccagtgtcct tgggtgggct agataggata tactgtatgc 138960
cggctccttc aagctgctga ctcactttat caatagttcc atttaaattg acttcagtgg 139020
tgagactgta tcctgtttgc tattgcttgt tgtgctatgg ggggaggggg gaggaatgtg 139080
taagatagtt aacatgggca aagggagatc ttggggtgca gcacttaaac tgcctcgtaa 139140
cccttttcat gatttcaacc acatttgcta gagggaggga gcagccacgg agttagaggc 139200
ccttggggtt tctcttttcc actgacaggc tttcccaggc agctggctag ttcattccct 139260
ccccagccag gtgcaggcgt aggaatatgg acatctggtt gctttggcct gctgccctct 139320
ttcaggggtc ctaagcccac aatcatgcct ccctaagacc ttggcatcct tccctctaag 139380
ccgttggcac ctctgtgcca cctctcacac tggctccaga cacacagcct gtgcttttgg 139440
agctgagatc actcgcttca ccctcctcat ctttgttctc caagtaaagc cacgaggtcg 139500
gggcgagggc agaggtgatc acctgcgtgt cccatctaca gacctgcagc ttcataaaac 139560
ttctgatttc tcttcagctt tgaaaagggt taccctgggc actggcctag agcctcacct 139620
cctaatagac ttagccccat gagtttgcca tgttgagcag gactatttct ggcacttgca 139680
agtcccatga tttcttcggt aattctgagg gtggggggag ggacatgaaa tcatcttagc 139740
ttagctttct gtctgtgaat gtctatatag tgtattgtgt gttttaacaa atgatttaca 139800
ctgactgttg ctgtaaaagt gaatttggaa ataaagttat tactctgatt aaataaggtc 139860
tccattcatg gattccaagg acaagaaagt catatagaat gtctattttt taagttcttt 139920
cccacgcacc cttagataat ttagctcaga acaggaaatg atagtattaa taaaagctgg 139980
acatcaggat taacagctct ctctggggcc ctgaaggtga gagttctcag acttgctcat 140040
ttgcagttgc ttctttgtga tgctggcaaa ccatcctagt cccattcaaa gggcaataca 140100
aagccttgtg gctgacctca cgatgcagca ctcagtttgc aagaccggca ccagtgtatg 140160
caaacctgag aaggttgggg atgaggatat gggatctttc atccctggaa atttagtcca 140220
gaggcctggg gctggagcag aacaccaagc caatcagctt aatgaatggc ttagattcct 140280
gctaggtttg cagagctgcc ttctttcctt tggtacctta ttatagattg aggagtattt 140340
ctgctaaacc aagataggga taaccagata gcatcttcat agcaatgcca caaaggaaaa 140400
caaaaacaaa acagtaatcc atcatattat tccttagtaa ctatgccaag gtcatgatac 140460
tgaatcctta gattgtttca aaatactact tttctttgct cttcctgatg tgtttgccac 140520
cgcaggcaga tgtttaagta aaacagattt taactgcagc tacaaaagca gcaacaggcc 140580
agcaaaagag aagtgctatc tcagagagca tggctttcag agccacaaga gacagcctca 140640
ctggctgttt cagcttgact gccatgcaaa gaagagagca gagggagaac cagccccacc 140700
cacttattca tcttgtacaa aaaaaaagca cctaccagcc taggctacat agtgagacac 140760
tatctccaca aaaaacccac gaaaactagc tgggtatggt ggcacatgcc tacagtccca 140820
gctactggta aggctgtggt gggaggatct cttgaggcca ggaaggagat ccaggctgca 140880
gtgagccaag attgcaccac tgcactccag tctggacaat cgagcaagat cccatctcaa 140940
acaataaaaa aaaaaagcgt gtaacctcct cagaagaaag atgttataat ctcaggcagc 141000
a 141001
<210> 2
<211> 6816
<212> DNA
<213> Homo sapiens
<220>
<221> CDS
<222> (323)..(2653)
<400> 2
ggacggccga gcggcagggc gctcgcgcgc gcccactagt ggccggagga gaaggctccc 60
gcggaggccg cgctgcccgc cccctcccct ggggaggctc gcgttcccgc tgctcgcgcc 120
tgcgccgccc gccggcctca ggaacgcgcc ctcttcgccg gcgcgcgccc tcgcagtcac 180
cgccacccac cagctccggc accaacagca gcgccgctgc caccgcccac cttctgccgc 240
cgccaccaca gccaccttct cctcctccgc tgtcctctcc cgtcctcgcc tctgtcgact 300
atcaggtgaa ctttgaacca gg atg gct gag ccc cgc cag gag ttc gaa gtg 352
Met Ala Glu Pro Arg Gln Glu Phe Glu Val
1 5 10
atg gaa gat cac gct ggg acg tac ggg ttg ggg gac agg aaa gat cag 400
Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln
15 20 25
ggg ggc tac acc atg cac caa gac caa gag ggt gac acg gac gct ggc 448
Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly
30 35 40
ctg aaa gaa tct ccc ctg cag acc ccc act gag gac gga tct gag gaa 496
Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu
45 50 55
ccg ggc tct gaa acc tct gat gct aag agc act cca aca gcg gaa gat 544
Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp
60 65 70
gtg aca gca ccc tta gtg gat gag gga gct ccc ggc aag cag gct gcc 592
Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala
75 80 85 90
gcg cag ccc cac acg gag atc cca gaa gga acc aca gct gaa gaa gca 640
Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala
95 100 105
ggc att gga gac acc ccc agc ctg gaa gac gaa gct gct ggt cac gtg 688
Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val
110 115 120
acc caa gag cct gaa agt ggt aag gtg gtc cag gaa ggc ttc ctc cga 736
Thr Gln Glu Pro Glu Ser Gly Lys Val Val Gln Glu Gly Phe Leu Arg
125 130 135
gag cca ggc ccc cca ggt ctg agc cac cag ctc atg tcc ggc atg cct 784
Glu Pro Gly Pro Pro Gly Leu Ser His Gln Leu Met Ser Gly Met Pro
140 145 150
ggg gct ccc ctc ctg cct gag ggc ccc aga gag gcc aca cgc caa cct 832
Gly Ala Pro Leu Leu Pro Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro
155 160 165 170
tcg ggg aca gga cct gag gac aca gag ggc ggc cgc cac gcc cct gag 880
Ser Gly Thr Gly Pro Glu Asp Thr Glu Gly Gly Arg His Ala Pro Glu
175 180 185
ctg ctc aag cac cag ctt cta gga gac ctg cac cag gag ggg ccg ccg 928
Leu Leu Lys His Gln Leu Leu Gly Asp Leu His Gln Glu Gly Pro Pro
190 195 200
ctg aag ggg gca ggg ggc aaa gag agg ccg ggg agc aag gag gag gtg 976
Leu Lys Gly Ala Gly Gly Lys Glu Arg Pro Gly Ser Lys Glu Glu Val
205 210 215
gat gaa gac cgc gac gtc gat gag tcc tcc ccc caa gac tcc cct ccc 1024
Asp Glu Asp Arg Asp Val Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro
220 225 230
tcc aag gcc tcc cca gcc caa gat ggg cgg cct ccc cag aca gcc gcc 1072
Ser Lys Ala Ser Pro Ala Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala
235 240 245 250
aga gaa gcc acc agc atc cca ggc ttc cca gcg gag ggt gcc atc ccc 1120
Arg Glu Ala Thr Ser Ile Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro
255 260 265
ctc cct gtg gat ttc ctc tcc aaa gtt tcc aca gag atc cca gcc tca 1168
Leu Pro Val Asp Phe Leu Ser Lys Val Ser Thr Glu Ile Pro Ala Ser
270 275 280
gag ccc gac ggg ccc agt gta ggg cgg gcc aaa ggg cag gat gcc ccc 1216
Glu Pro Asp Gly Pro Ser Val Gly Arg Ala Lys Gly Gln Asp Ala Pro
285 290 295
ctg gag ttc acg ttt cac gtg gaa atc aca ccc aac gtg cag aag gag 1264
Leu Glu Phe Thr Phe His Val Glu Ile Thr Pro Asn Val Gln Lys Glu
300 305 310
cag gcg cac tcg gag gag cat ttg gga agg gct gca ttt cca ggg gcc 1312
Gln Ala His Ser Glu Glu His Leu Gly Arg Ala Ala Phe Pro Gly Ala
315 320 325 330
cct gga gag ggg cca gag gcc cgg ggc ccc tct ttg gga gag gac aca 1360
Pro Gly Glu Gly Pro Glu Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr
335 340 345
aaa gag gct gac ctt cca gag ccc tct gaa aag cag cct gct gct gct 1408
Lys Glu Ala Asp Leu Pro Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala
350 355 360
ccg cgg ggg aag ccc gtc agc cgg gtc cct caa ctc aaa gct cgc atg 1456
Pro Arg Gly Lys Pro Val Ser Arg Val Pro Gln Leu Lys Ala Arg Met
365 370 375
gtc agt aaa agc aaa gac ggg act gga agc gat gac aaa aaa gcc aag 1504
Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys
380 385 390
aca tcc aca cgt tcc tct gct aaa acc ttg aaa aat agg cct tgc ctt 1552
Thr Ser Thr Arg Ser Ser Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu
395 400 405 410
agc ccc aaa cac ccc act cct ggt agc tca gac cct ctg atc caa ccc 1600
Ser Pro Lys His Pro Thr Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro
415 420 425
tcc agc cct gct gtg tgc cca gag cca cct tcc tct cct aaa tac gtc 1648
Ser Ser Pro Ala Val Cys Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val
430 435 440
tct tct gtc act tcc cga act ggc agt tct gga gca aag gag atg aaa 1696
Ser Ser Val Thr Ser Arg Thr Gly Ser Ser Gly Ala Lys Glu Met Lys
445 450 455
ctc aag ggg gct gat ggt aaa acg aag atc gcc aca ccg cgg gga gca 1744
Leu Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala
460 465 470
gcc cct cca ggc cag aag ggc cag gcc aac gcc acc agg att cca gca 1792
Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala
475 480 485 490
aaa acc ccg ccc gct cca aag aca cca ccc agc tct gcg act aag caa 1840
Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Ala Thr Lys Gln
495 500 505
gtc cag aga aga cca ccc cct gca ggg ccc aga tct gag aga ggt gaa 1888
Val Gln Arg Arg Pro Pro Pro Ala Gly Pro Arg Ser Glu Arg Gly Glu
510 515 520
cct cca aaa tca ggg gat cgc agc ggc tac agc agc ccc ggc tcc cca 1936
Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro
525 530 535
ggc act ccc ggc agc cgc tcc cgc acc ccg tcc ctt cca acc cca ccc 1984
Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro
540 545 550
acc cgg gag ccc aag aag gtg gca gtg gtc cgt act cca ccc aag tcg 2032
Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser
555 560 565 570
ccg tct tcc gcc aag agc cgc ctg cag aca gcc ccc gtg ccc atg cca 2080
Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro
575 580 585
gac ctg aag aat gtc aag tcc aag atc ggc tcc act gag aac ctg aag 2128
Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys
590 595 600
cac cag ccg gga ggc ggg aag gtg cag ata att aat aag aag ctg gat 2176
His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp
605 610 615
ctt agc aac gtc cag tcc aag tgt ggc tca aag gat aat atc aaa cac 2224
Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His
620 625 630
gtc ccg gga ggc ggc agt gtg caa ata gtc tac aaa cca gtt gac ctg 2272
Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu
635 640 645 650
agc aag gtg acc tcc aag tgt ggc tca tta ggc aac atc cat cat aaa 2320
Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys
655 660 665
cca gga ggt ggc cag gtg gaa gta aaa tct gag aag ctt gac ttc aag 2368
Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys
670 675 680
gac aga gtc cag tcg aag att ggg tcc ctg gac aat atc acc cac gtc 2416
Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val
685 690 695
cct ggc gga gga aat aaa aag att gaa acc cac aag ctg acc ttc cgc 2464
Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg
700 705 710
gag aac gcc aaa gcc aag aca gac cac ggg gcg gag atc gtg tac aag 2512
Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys
715 720 725 730
tcg cca gtg gtg tct ggg gac acg tct cca cgg cat ctc agc aat gtc 2560
Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val
735 740 745
tcc tcc acc ggc agc atc gac atg gta gac tcg ccc cag ctc gcc acg 2608
Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr
750 755 760
cta gct gac gag gtg tct gcc tcc ctg gcc aag cag ggt ttg tga 2653
Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu
765 770 775
tcaggcccct ggggcggtca ataattgtgg agaggagaga atgagagagt gtggaaaaaa 2713
aaagaataat gacccggccc ccgccctctg cccccagctg ctcctcgcag ttcggttaat 2773
tggttaatca cttaacctgc ttttgtcact cggctttggc tcgggacttc aaaatcagtg 2833
atgggagtaa gagcaaattt catctttcca aattgatggg tgggctagta ataaaatatt 2893
taaaaaaaaa cattcaaaaa catggccaca tccaacattt cctcaggcaa ttccttttga 2953
ttcttttttc ttccccctcc atgtagaaga gggagaagga gaggctctga aagctgcttc 3013
tgggggattt caagggactg ggggtgccaa ccacctctgg ccctgttgtg ggggtgtcac 3073
agaggcagtg gcagcaacaa aggatttgaa acttggtgtg ttcgtggagc cacaggcaga 3133
cgatgtcaac cttgtgtgag tgtgacgggg gttggggtgg ggcgggaggc cacgggggag 3193
gccgaggcag gggctgggca gaggggagag gaagcacaag aagtgggagt gggagaggaa 3253
gccacgtgct ggagagtaga catccccctc cttgccgctg ggagagccaa ggcctatgcc 3313
acctgcagcg tctgagcggc cgcctgtcct tggtggccgg gggtgggggc ctgctgtggg 3373
tcagtgtgcc accctctgca gggcagcctg tgggagaagg gacagcgggt aaaaagagaa 3433
ggcaagctgg caggagggtg gcacttcgtg gatgacctcc ttagaaaaga ctgaccttga 3493
tgtcttgaga gcgctggcct cttcctccct ccctgcaggg tagggggcct gagttgaggg 3553
gcttccctct gctccacaga aaccctgttt tattgagttc tgaaggttgg aactgctgcc 3613
atgattttgg ccactttgca gacctgggac tttagggcta accagttctc tttgtaagga 3673
cttgtgcctc ttgggagacg tccacccgtt tccaagcctg ggccactggc atctctggag 3733
tgtgtggggg tctgggaggc aggtcccgag ccccctgtcc ttcccacggc cactgcagtc 3793
accccgtctg cgccgctgtg ctgttgtctg ccgtgagagc ccaatcactg cctatacccc 3853
tcatcacacg tcacaatgtc ccgaattccc agcctcacca ccccttctca gtaatgaccc 3913
tggttggttg caggaggtac ctactccata ctgagggtga aattaaggga aggcaaagtc 3973
caggcacaag agtgggaccc cagcctctca ctctcagttc cactcatcca actgggaccc 4033
tcaccacgaa tctcatgatc tgattcggtt ccctgtctcc tcctcccgtc acagatgtga 4093
gccagggcac tgctcagctg tgaccctagg tgtttctgcc ttgttgacat ggagagagcc 4153
ctttcccctg agaaggcctg gccccttcct gtgctgagcc cacagcagca ggctgggtgt 4213
cttggttgtc agtggtggca ccaggatgga agggcaaggc acccagggca ggcccacagt 4273
cccgctgtcc cccacttgca ccctagcttg tagctgccaa cctcccagac agcccagccc 4333
gctgctcagc tccacatgca tagtatcagc cctccacacc cgacaaaggg gaacacaccc 4393
ccttggaaat ggttcttttc ccccagtccc agctggaagc catgctgtct gttctgctgg 4453
agcagctgaa catatacata gatgttgccc tgccctcccc atctgcaccc tgttgagttg 4513
tagttggatt tgtctgttta tgcttggatt caccagagtg actatgatag tgaaaagaaa 4573
aaaaaaaaaa aaaaaggacg catgtatctt gaaatgcttg taaagaggtt tctaacccac 4633
cctcacgagg tgtctctcac ccccacactg ggactcgtgt ggcctgtgtg gtgccaccct 4693
gctggggcct cccaagtttt gaaaggcttt cctcagcacc tgggacccaa cagagaccag 4753
cttctagcag ctaaggaggc cgttcagctg tgacgaaggc ctgaagcaca ggattaggac 4813
tgaagcgatg atgtcccctt ccctacttcc ccttggggct ccctgtgtca gggcacagac 4873
taggtcttgt ggctggtctg gcttgcggcg cgaggatggt tctctctggt catagcccga 4933
agtctcatgg cagtcccaaa ggaggcttac aactcctgca tcacaagaaa aaggaagcca 4993
ctgccagctg gggggatctg cagctcccag aagctccgtg agcctcagcc acccctcaga 5053
ctgggttcct ctccaagctc gccctctgga ggggcagcgc agcctcccac caagggccct 5113
gcgaccacag cagggattgg gatgaattgc ctgtcctgga tctgctctag aggcccaagc 5173
tgcctgcctg aggaaggatg acttgacaag tcaggagaca ctgttcccaa agccttgacc 5233
agagcacctc agcccgctga ccttgcacaa actccatctg ctgccatgag aaaagggaag 5293
ccgcctttgc aaaacattgc tgcctaaaga aactcagcag cctcaggccc aattctgcca 5353
cttctggttt gggtacagtt aaaggcaacc ctgagggact tggcagtaga aatccagggc 5413
ctcccctggg gctggcagct tcgtgtgcag ctagagcttt acctgaaagg aagtctctgg 5473
gcccagaact ctccaccaag agcctccctg ccgttcgctg agtcccagca attctcctaa 5533
gttgaaggga tctgagaagg agaaggaaat gtggggtaga tttggtggtg gttagagata 5593
tgcccccctc attactgcca acagtttcgg ctgcatttct tcacgcacct cggttcctct 5653
tcctgaagtt cttgtgccct gctcttcagc accatgggcc ttcttatacg gaaggctctg 5713
ggatctcccc cttgtggggc aggctcttgg ggccagccta agatcatggt ttagggtgat 5773
cagtgctggc agataaattg aaaaggcacg ctggcttgtg atcttaaatg aggacaatcc 5833
ccccagggct gggcactcct cccctcccct cacttctccc acctgcagag ccagtgtcct 5893
tgggtgggct agataggata tactgtatgc cggctccttc aagctgctga ctcactttat 5953
caatagttcc atttaaattg acttcagtgg tgagactgta tcctgtttgc tattgcttgt 6013
tgtgctatgg ggggaggggg gaggaatgtg taagatagtt aacatgggca aagggagatc 6073
ttggggtgca gcacttaaac tgcctcgtaa cccttttcat gatttcaacc acatttgcta 6133
gagggaggga gcagccacgg agttagaggc ccttggggtt tctcttttcc actgacaggc 6193
tttcccaggc agctggctag ttcattccct ccccagccag gtgcaggcgt aggaatatgg 6253
acatctggtt gctttggcct gctgccctct ttcaggggtc ctaagcccac aatcatgcct 6313
ccctaagacc ttggcatcct tccctctaag ccgttggcac ctctgtgcca cctctcacac 6373
tggctccaga cacacagcct gtgcttttgg agctgagatc actcgcttca ccctcctcat 6433
ctttgttctc caagtaaagc cacgaggtcg gggcgagggc agaggtgatc acctgcgtgt 6493
cccatctaca gacctgcagc ttcataaaac ttctgatttc tcttcagctt tgaaaagggt 6553
taccctgggc actggcctag agcctcacct cctaatagac ttagccccat gagtttgcca 6613
tgttgagcag gactatttct ggcacttgca agtcccatga tttcttcggt aattctgagg 6673
gtggggggag ggacatgaaa tcatcttagc ttagctttct gtctgtgaat gtctatatag 6733
tgtattgtgt gttttaacaa atgatttaca ctgactgttg ctgtaaaagt gaatttggaa 6793
ataaagttat tactctgatt aaa 6816
<210> 3
<211> 5544
<212> DNA
<213> Homo sapiens
<220>
<221> CDS
<222> (323)..(1381)
<400> 3
ggacggccga gcggcagggc gctcgcgcgc gcccactagt ggccggagga gaaggctccc 60
gcggaggccg cgctgcccgc cccctcccct ggggaggctc gcgttcccgc tgctcgcgcc 120
tgcgccgccc gccggcctca ggaacgcgcc ctcttcgccg gcgcgcgccc tcgcagtcac 180
cgccacccac cagctccggc accaacagca gcgccgctgc caccgcccac cttctgccgc 240
cgccaccaca gccaccttct cctcctccgc tgtcctctcc cgtcctcgcc tctgtcgact 300
atcaggtgaa ctttgaacca gg atg gct gag ccc cgc cag gag ttc gaa gtg 352
Met Ala Glu Pro Arg Gln Glu Phe Glu Val
1 5 10
atg gaa gat cac gct ggg acg tac ggg ttg ggg gac agg aaa gat cag 400
Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln
15 20 25
ggg ggc tac acc atg cac caa gac caa gag ggt gac acg gac gct ggc 448
Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly
30 35 40
ctg aaa gct gaa gaa gca ggc att gga gac acc ccc agc ctg gaa gac 496
Leu Lys Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp
45 50 55
gaa gct gct ggt cac gtg acc caa gct cgc atg gtc agt aaa agc aaa 544
Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys
60 65 70
gac ggg act gga agc gat gac aaa aaa gcc aag ggg gct gat ggt aaa 592
Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys
75 80 85 90
acg aag atc gcc aca ccg cgg gga gca gcc cct cca ggc cag aag ggc 640
Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly
95 100 105
cag gcc aac gcc acc agg att cca gca aaa acc ccg ccc gct cca aag 688
Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys
110 115 120
aca cca ccc agc tct ggt gaa cct cca aaa tca ggg gat cgc agc ggc 736
Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly
125 130 135
tac agc agc ccc ggc tcc cca ggc act ccc ggc agc cgc tcc cgc acc 784
Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr
140 145 150
ccg tcc ctt cca acc cca ccc acc cgg gag ccc aag aag gtg gca gtg 832
Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val
155 160 165 170
gtc cgt act cca ccc aag tcg ccg tct tcc gcc aag agc cgc ctg cag 880
Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln
175 180 185
aca gcc ccc gtg ccc atg cca gac ctg aag aat gtc aag tcc aag atc 928
Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile
190 195 200
ggc tcc act gag aac ctg aag cac cag ccg gga ggc ggg aag gtg caa 976
Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln
205 210 215
ata gtc tac aaa cca gtt gac ctg agc aag gtg acc tcc aag tgt ggc 1024
Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly
220 225 230
tca tta ggc aac atc cat cat aaa cca gga ggt ggc cag gtg gaa gta 1072
Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val
235 240 245 250
aaa tct gag aag ctt gac ttc aag gac aga gtc cag tcg aag att ggg 1120
Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly
255 260 265
tcc ctg gac aat atc acc cac gtc cct ggc gga gga aat aaa aag att 1168
Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile
270 275 280
gaa acc cac aag ctg acc ttc cgc gag aac gcc aaa gcc aag aca gac 1216
Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp
285 290 295
cac ggg gcg gag atc gtg tac aag tcg cca gtg gtg tct ggg gac acg 1264
His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr
300 305 310
tct cca cgg cat ctc agc aat gtc tcc tcc acc ggc agc atc gac atg 1312
Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met
315 320 325 330
gta gac tcg ccc cag ctc gcc acg cta gct gac gag gtg tct gcc tcc 1360
Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser
335 340 345
ctg gcc aag cag ggt ttg tga tcaggcccct ggggcggtca ataattgtgg 1411
Leu Ala Lys Gln Gly Leu
350
agaggagaga atgagagagt gtggaaaaaa aaagaataat gacccggccc ccgccctctg 1471
cccccagctg ctcctcgcag ttcggttaat tggttaatca cttaacctgc ttttgtcact 1531
cggctttggc tcgggacttc aaaatcagtg atgggagtaa gagcaaattt catctttcca 1591
aattgatggg tgggctagta ataaaatatt taaaaaaaaa cattcaaaaa catggccaca 1651
tccaacattt cctcaggcaa ttccttttga ttcttttttc ttccccctcc atgtagaaga 1711
gggagaagga gaggctctga aagctgcttc tgggggattt caagggactg ggggtgccaa 1771
ccacctctgg ccctgttgtg ggggtgtcac agaggcagtg gcagcaacaa aggatttgaa 1831
acttggtgtg ttcgtggagc cacaggcaga cgatgtcaac cttgtgtgag tgtgacgggg 1891
gttggggtgg ggcgggaggc cacgggggag gccgaggcag gggctgggca gaggggagag 1951
gaagcacaag aagtgggagt gggagaggaa gccacgtgct ggagagtaga catccccctc 2011
cttgccgctg ggagagccaa ggcctatgcc acctgcagcg tctgagcggc cgcctgtcct 2071
tggtggccgg gggtgggggc ctgctgtggg tcagtgtgcc accctctgca gggcagcctg 2131
tgggagaagg gacagcgggt aaaaagagaa ggcaagctgg caggagggtg gcacttcgtg 2191
gatgacctcc ttagaaaaga ctgaccttga tgtcttgaga gcgctggcct cttcctccct 2251
ccctgcaggg tagggggcct gagttgaggg gcttccctct gctccacaga aaccctgttt 2311
tattgagttc tgaaggttgg aactgctgcc atgattttgg ccactttgca gacctgggac 2371
tttagggcta accagttctc tttgtaagga cttgtgcctc ttgggagacg tccacccgtt 2431
tccaagcctg ggccactggc atctctggag tgtgtggggg tctgggaggc aggtcccgag 2491
ccccctgtcc ttcccacggc cactgcagtc accccgtctg cgccgctgtg ctgttgtctg 2551
ccgtgagagc ccaatcactg cctatacccc tcatcacacg tcacaatgtc ccgaattccc 2611
agcctcacca ccccttctca gtaatgaccc tggttggttg caggaggtac ctactccata 2671
ctgagggtga aattaaggga aggcaaagtc caggcacaag agtgggaccc cagcctctca 2731
ctctcagttc cactcatcca actgggaccc tcaccacgaa tctcatgatc tgattcggtt 2791
ccctgtctcc tcctcccgtc acagatgtga gccagggcac tgctcagctg tgaccctagg 2851
tgtttctgcc ttgttgacat ggagagagcc ctttcccctg agaaggcctg gccccttcct 2911
gtgctgagcc cacagcagca ggctgggtgt cttggttgtc agtggtggca ccaggatgga 2971
agggcaaggc acccagggca ggcccacagt cccgctgtcc cccacttgca ccctagcttg 3031
tagctgccaa cctcccagac agcccagccc gctgctcagc tccacatgca tagtatcagc 3091
cctccacacc cgacaaaggg gaacacaccc ccttggaaat ggttcttttc ccccagtccc 3151
agctggaagc catgctgtct gttctgctgg agcagctgaa catatacata gatgttgccc 3211
tgccctcccc atctgcaccc tgttgagttg tagttggatt tgtctgttta tgcttggatt 3271
caccagagtg actatgatag tgaaaagaaa aaaaaaaaaa aaaaaggacg catgtatctt 3331
gaaatgcttg taaagaggtt tctaacccac cctcacgagg tgtctctcac ccccacactg 3391
ggactcgtgt ggcctgtgtg gtgccaccct gctggggcct cccaagtttt gaaaggcttt 3451
cctcagcacc tgggacccaa cagagaccag cttctagcag ctaaggaggc cgttcagctg 3511
tgacgaaggc ctgaagcaca ggattaggac tgaagcgatg atgtcccctt ccctacttcc 3571
ccttggggct ccctgtgtca gggcacagac taggtcttgt ggctggtctg gcttgcggcg 3631
cgaggatggt tctctctggt catagcccga agtctcatgg cagtcccaaa ggaggcttac 3691
aactcctgca tcacaagaaa aaggaagcca ctgccagctg gggggatctg cagctcccag 3751
aagctccgtg agcctcagcc acccctcaga ctgggttcct ctccaagctc gccctctgga 3811
ggggcagcgc agcctcccac caagggccct gcgaccacag cagggattgg gatgaattgc 3871
ctgtcctgga tctgctctag aggcccaagc tgcctgcctg aggaaggatg acttgacaag 3931
tcaggagaca ctgttcccaa agccttgacc agagcacctc agcccgctga ccttgcacaa 3991
actccatctg ctgccatgag aaaagggaag ccgcctttgc aaaacattgc tgcctaaaga 4051
aactcagcag cctcaggccc aattctgcca cttctggttt gggtacagtt aaaggcaacc 4111
ctgagggact tggcagtaga aatccagggc ctcccctggg gctggcagct tcgtgtgcag 4171
ctagagcttt acctgaaagg aagtctctgg gcccagaact ctccaccaag agcctccctg 4231
ccgttcgctg agtcccagca attctcctaa gttgaaggga tctgagaagg agaaggaaat 4291
gtggggtaga tttggtggtg gttagagata tgcccccctc attactgcca acagtttcgg 4351
ctgcatttct tcacgcacct cggttcctct tcctgaagtt cttgtgccct gctcttcagc 4411
accatgggcc ttcttatacg gaaggctctg ggatctcccc cttgtggggc aggctcttgg 4471
ggccagccta agatcatggt ttagggtgat cagtgctggc agataaattg aaaaggcacg 4531
ctggcttgtg atcttaaatg aggacaatcc ccccagggct gggcactcct cccctcccct 4591
cacttctccc acctgcagag ccagtgtcct tgggtgggct agataggata tactgtatgc 4651
cggctccttc aagctgctga ctcactttat caatagttcc atttaaattg acttcagtgg 4711
tgagactgta tcctgtttgc tattgcttgt tgtgctatgg ggggaggggg gaggaatgtg 4771
taagatagtt aacatgggca aagggagatc ttggggtgca gcacttaaac tgcctcgtaa 4831
cccttttcat gatttcaacc acatttgcta gagggaggga gcagccacgg agttagaggc 4891
ccttggggtt tctcttttcc actgacaggc tttcccaggc agctggctag ttcattccct 4951
ccccagccag gtgcaggcgt aggaatatgg acatctggtt gctttggcct gctgccctct 5011
ttcaggggtc ctaagcccac aatcatgcct ccctaagacc ttggcatcct tccctctaag 5071
ccgttggcac ctctgtgcca cctctcacac tggctccaga cacacagcct gtgcttttgg 5131
agctgagatc actcgcttca ccctcctcat ctttgttctc caagtaaagc cacgaggtcg 5191
gggcgagggc agaggtgatc acctgcgtgt cccatctaca gacctgcagc ttcataaaac 5251
ttctgatttc tcttcagctt tgaaaagggt taccctgggc actggcctag agcctcacct 5311
cctaatagac ttagccccat gagtttgcca tgttgagcag gactatttct ggcacttgca 5371
agtcccatga tttcttcggt aattctgagg gtggggggag ggacatgaaa tcatcttagc 5431
ttagctttct gtctgtgaat gtctatatag tgtattgtgt gttttaacaa atgatttaca 5491
ctgactgttg ctgtaaaagt gaatttggaa ataaagttat tactctgatt aaa 5544
<210> 4
<211> 137001
<212> DNA
<213> Homo sapiens
<400> 4
caaaaattag ccgggagtgg tggcatatgc ctgtaatccc agtagctggg aggctgagac 60
aggaaaatcg cttgaacccg ggaaacaggt tgcagtgagc cgagatcgtg ccactgcact 120
ccagcctggg caacagagcg agactccatc tcaaaaaaac aaaacaaaca cacacaaaaa 180
accaaaaata aataaataaa atgatcactt ctgaatactg atctaactag gggttgcagg 240
gtgggctgat atagggagaa actggagagc aaggagatca ctaaggtccc tacatgtcca 300
gaaccaagat agaggtcttg aactaggatg gtggcagtta gaacaacaac aacaaaaagt 360
caattccagg ctgagtgcag tggctcatgc ttgtaatccc aacgctttgg gaggctgagg 420
tgggagttag aaagcagcct gggcaacact gcaagacctc ctctctaaaa aaaaaaaaaa 480
aaaaaagtta gccaggtgtg gtggtgccca cctgtagtcc cagcaactca gaaggctgag 540
gtgggaagat tgcttgagcc ccaggagttc aagcttgccg tgagctacga ttgtgccact 600
gcactccagc ctgagcaaga ccttgtctcc aaaaaaaggt caattccact gacttttcta 660
aggtgtacac catcaagggg cagctccatc tccaggccat tggctcatga gacattctgt 720
agtcagaagg ctagggcaga ttgctttgag caagccccca tggtggttct cactcctact 780
tctttgggta tatgcccctc tgtttaaaaa taaagttaat atgcatttaa aaaaaaaaag 840
gagaaaaagg tcagttccag aaactgtgtg aataaagcat tttacttgct ttttctatta 900
atctataaca tatgttgatt ttttaaaaag aatataagag ctatgcaaat tggagcttca 960
agacaacttc ccatctccct aggaggagat ggctgcccta aaccccccta catagaaatc 1020
atcccactgc ttgggcttaa acttgatgtt ggggaaatga aaaatccaag ctaaggccga 1080
agcctggggc ctgggcgacc agcagaatga ggaccactgg tcagtttcag gctgaggtgc 1140
gtcttccagg ggacaatctc tagctggccc ttaaacattc agacttcaag ctctatttac 1200
agcataaagg tgtttcaaaa gacgtgatac aaataactgc aaatgctctg cgatgtgtta 1260
agcactgttt gaaattcgtc taatttaaga tttttttttc tgacgtaacg gttagattca 1320
cgtttctttt tttttaagta cagttctact gtattgtaac tgagttagct tgctttaagc 1380
cgatttgtta aggaaaggat tcaccttggt cagtaacaaa aaaggtggga aaaaagcaag 1440
gagaaaggaa gcagcctggg ggaaagagac cttagccagg ggggcggttt cgggactacg 1500
aagggtcggg gcggacggac tcgagggccg gccacgtgga aggccgctca ggacttctgt 1560
aggagaggac accgccccag gctgactgaa agtaaagggc agcggaccca gcggcggagc 1620
cactggcctt gccccgaccc cgcatggccc gaaggaggac acccaccccc acaacgacac 1680
aaagactcca actacaggag gtggagaaag cgcgtgcgcc acggaacgcg cgtgcgcgct 1740
gcggtcagcg ccgcggcctg aggcgtagcg ggagggggac cgcgaaaggg cagcgccgag 1800
aggaacgagc cgggagacgc cggacggccg agcggcaggg cgctcgcgcg cgcccactag 1860
tggccggagg agaaggctcc cgcggaggcc gcgctgcccg ccccctcccc tggggaggct 1920
cgcgttcccg ctgctcgcgc ctgcgccgcc cgccggcctc aggaacgcgc cctcttcgcc 1980
ggcgcgcgcc ctcgcagtca ccgccaccca ccagctccgg caccaacagc agcgccgctg 2040
ccaccgccca ccttctgccg ccgccaccac agccaccttc tcctcctccg ctgtcctctc 2100
ccgtcctcgc ctctgtcgac tatcaggtaa gcgccgcggc tccgaaatct gcctcgccgt 2160
ccgcctctgt gcacccctgc gccgccgccc ctcgccctcc ctctccgcag actggggctt 2220
cgtgcgccgg gcatcggtcg gggccaccgc agggcccctc cctgcctccc ctgctcgggg 2280
gctggggcca gggcggcctg gaaagggacc tgagcaaggg atgcacgcac gcgtgagtgc 2340
gcgcgtgtgt gtgtgctgga gggtcttcac caccagattc gcgcagaccc caggtggagg 2400
ctgtgccggc agggtggggc gcggcggcgg tgacttgggg gagggggctg cccttcactc 2460
tcgactgcag ccttttgccg caatgggcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 2520
gtgtgtgtgt gtggaggggt ccgataacga cccccgaaac cgaatctgaa atccgctgtc 2580
cctgccgctg ttcgccatca gctctaagaa agacgtggat cgggttctag aaaagatgac 2640
tccctgcacg cccctccctg cacctcccga gcagtgattc cgacagggcc ttcactgccc 2700
ctgattttag gcgggggccg gccccctccc cttttcctcc ttcagaaacc cgtaggggac 2760
atttgggggc tgggagaaat cgaggagatg gggaggggtc cacgcgctgt cactttagtt 2820
gcccttcccc ctgcgcacgc ctggcacaga gacgcgagca gcgccgtgcc tgagaacagt 2880
gcgcggatcc cactgtgcac gctcgcaaag gcagggttca cctggcctgg cgatgtggac 2940
ggactcggcg gccgctggtc cccgttcgcg ggcacgcaca gccgcagcca cgcacggatg 3000
ggcgcggggc tgcaggtgca tctcggggcg gatttctttc tcagcgctcg gagcgcaggg 3060
cgcccggcgt gtgcgctccc tgccggaggc gcggggctgg cgcgcagggc tcgcccctca 3120
ctgcggcagt gggtgtggac cctggtgggc gaggaagggg gaggataggc tgtgcctcct 3180
cccactcccg cccccagccc cccttttttt ccccctcgga acgcgaggtg ccatcttttt 3240
tcggcgtgtc acgtctttac ggtgccatgc caaaccgggt ggccgggctt cataggacag 3300
ggcggggcct ggcattaaag ggagggggac aatcagcgct gaaatcttgg cgttttgctg 3360
ctgcgggcgt gagcactggg ggcgttcgcc cagcaccttc ttcgggggct ctttgctttg 3420
tctgtagagg ttacgtgatc tgcgctccca gccctggttt ctggctttta ttctgagggt 3480
gttcagtcaa cctcccccct acgcccatgc gcctctcttt cctttttcgc tcctcatttc 3540
cgagcccatt gttggatctc gaggcttgct gggttcgatg aactcgagtc aaccccccga 3600
cccccggcac gcatggaacg ggcgtgaccg cgcgcagcct cgtctcggag tctgccggcg 3660
ccgggaagct tctgaaggga tgggattcga gtctccgtgc gcgctgcggg cggcggcaga 3720
gggatctcgc ccctccctac accccaagtg tcctgagggc cacgccacac caggttgccc 3780
agcgagggac gctggctacc catccgggga tgggtgggga gccctggcgg ggcctctccg 3840
gctttacgcc ctgttgcttc gcctggccgg agaatgtgag gaaggggcat aaggttactg 3900
gtgcttcggc cacacccatc tttctgagcc cactggactg ggcgcagagg ggggattgcc 3960
atggaaacca caggtgtccg gagaggggat cttggggctg gcctcacccc ttccctgcgg 4020
agattgggga ccctggggta gggggagccg cgcccagtcg gcctcctgga ggacacggga 4080
ggaagccccg aacccccgcg cctgaggctg tttctgattg gcccctggag gccgcagaca 4140
cgcagatagg cggccctggg tgtattttta ttaatattat gtccgtactg attaatatta 4200
tttatcttaa ataaatttca cccgtgtcca agttcaccgc gcccccaaaa ccgagtctgg 4260
ggcggcaggg ggaactcctg gccaacgaat ccatgcctcg ccctcctgtg atgaacctgg 4320
tacgcacggt tttctggtta attctatcgc tgaaaactgg tgcggggggc gcacttctga 4380
gacggaagag catctaggag ctgaatcctc cacgcgggtc gcccaggttg atctgaattt 4440
ctggggaatg gcttggctgc ccgcccggga ccaggccgac cctccttgac ggtggcgtag 4500
agggctggag cctgggtact gcgaggctcc tcgcatggct gggcccgccg cgaggggttg 4560
cagagcggct cagggatcga ttcaagcatc gtctctcctc cctcgccccc agacagagct 4620
gggcgcgggg ttccccttcc agatggagcg agggtctcgg ggtggccccg gaaaagggga 4680
gcccgcggcc acggctacgt attgccatct cgcgagcaga gatgtcacct cctgcctttg 4740
gaggaaaggg agcccggtgg ggatgagcgc atttagccca atgctgggaa caaagcgcac 4800
tccgcgcttc tgcgatttcg ctccattttg aaatgtgttg gcgctttggt ggggccgctg 4860
cggtgggcaa ggccgggggc gctgttaatg gaggaacctc agggggacgg tccttcgtag 4920
gaaactctat cctggctctg cgcgcgcttt aaggaaatgg cttccctcca ggacctcgag 4980
ggatgcagct tttgcgcgga tgacggtggg gtgctgaacc agccggtgcg cctctggaaa 5040
tgtctgggca cggatcctgg ggccatcgac gactcctccc cattcccagc aggcgggagc 5100
tcttacattc cgagcgagtg acccctctca ccctctggcg ctcacacacc tgtaactcca 5160
aacctccgtc tcagaatggt ccaggctgga agggatgatg ggggctccga cagcgactgc 5220
ctagctcacc cctctgcgtg ctcaggctcc aggctcagca ggaccaattt gagttctatc 5280
tgatccccct cggcccctta actgacccat cctacaggag acagggaaat gtctttccta 5340
ccgcggttga ttctggggtg tcattttgtg ttttgtgatg gctgcttata tttactgtat 5400
aagcattgta tttactgtat aagcattgta ttataattac tgtataagct gcttatattt 5460
actgtataag catctccaaa tcctccctct acgtaaacaa attaatggat aaacagataa 5520
gtgtatcccc tgcccccacc cctgctacgc aggtccggag tgactcttga agctcataca 5580
ttccttggcc aagtttgctt ctctaacaga tgtttatata gcaataacct ggcttggctc 5640
ttgggttcac ctttggacga tttggggaag gggcttgttg gctttgctgg gttttggatg 5700
agtgacagtc catgactgtt cctgctggaa gggcgtgact tttaagtggt ttctaatatc 5760
aggcattgct cctccgacag gaacaaaaga aatggatact gcccataaat tgttagaaaa 5820
cttagaatcg ctttgattga ggaaaggtta gatttattcc ggttggaaaa agtggccttt 5880
ctattaaacg tgccctttga ccctcatgcc cttggaggtc ggtgccagcc tggagatggg 5940
ataagattgt ggttttcctt ctgccttttt aacatctgtt gttacagtcc atttgttgaa 6000
aatttaaaga aactgtttta ttccactttc cctcagcatt tatgtgtgtg gtttcagtag 6060
ctctgtggct atatgtacga acacgtgtta tttttccaat tggacatgtg ataattttcc 6120
aactggacct tgccttctat tgatgtattt atttagcatc ttccttactc cctccttgaa 6180
aaagaatcac tcaaaaacaa ataaaaacag ccgtaggggc ctaatacagt gctagacata 6240
caagaggtat tcggtccata ccaaatggat tttatccatg aaggataaat ggggaaatac 6300
agtgggaagc aggtgggaaa ctgcgtttga ctctgctctt tcctccacca ccactttcct 6360
catcaccgtg ttcagagacc cccaaagccc cctcacactc ccagaaacac ccccctggcc 6420
actcctaact tgccatgccc aggagttagg tgcttccact agtgacatgg agctggcgtt 6480
tggggggcac ctcagcaggt gacgggaaga gaagacccca gcctcaccag ctgggctgca 6540
gcagggagag gagtcctcat gttccagcag ggactctcag ctgttttcct gtaaaaccat 6600
ggttctcaac tgggggccac tgagatgtct agagagatgt ttttgttttc acaactcggg 6660
gagggtgcta ctgacatctt gtgggtagag gccaggaatg ctgttaaaca tcctacaagg 6720
aaggcacagg acagtctcct acatcaaaat atgacccagt cccaatgtca ccactgctgg 6780
ggttgacact ggcactgcta tcttaattac attcattgag tgtcttttag gaggccctat 6840
tctaagtgct tgctaagatt atctcattta atcctcacaa cacttccgct atgtagcagg 6900
tgctgttatt atctccgtga tggggaaact gaagcacaga gagggttagt aacttgctaa 6960
aggtcacaga gccagtgggt ggtggagctg gttgcctgac actagttccc tcccctctca 7020
gccacatgtg ggtttacttg gccattgtgg actagtctgg gaacccagat atgatctata 7080
acattgaccc agtagaatat tgattccaaa accactgtct cacaaatgaa tttttacaag 7140
agtctgtaat cggagcatga cccagaataa ggttagggag atgtggagtt aaagctctca 7200
atttcttatc tggccccgac acagagagca aggcatttca ctctacattg gtgctctgtt 7260
tataaaacaa agagcaaata tctcttccta aggtccttaa acctcttccc ccaatccagg 7320
gtttctggac tgctctgcca tatgacgggg cagctggttt gattgaccca gggaaggctg 7380
gaaatcaaga ctgggggatc aagacgtaga ttcagtgtgg ccaaggtcaa gtctctgagg 7440
tttagggaca tcagatcccc agcttaggtt ctgtacctcg gcaaggtgaa agcgttggcg 7500
cccactgatg aggcctgctc tgagattgtg ggtgtgggtt gagttgggtg ggcataggca 7560
agtcctcttg taagaatctt ttggcaaaga tgggcctggg aggcttttct cacttcctgg 7620
ggcccaggct ttgcaataag tattccatta tactgtggta ccttggggct acctgagaat 7680
cctctgtctc gcccctgttg ccttgccaaa gagtttgctg tccaagaatt cctttcctgt 7740
ctccaggtgc catgctcctg ccacctctgc caggttccct gcctgcccag atggctccca 7800
actgagtgtg aggaggaatt tgagacaggt tttgagcttt ctgggttctc cagttaggaa 7860
actttctgta agcatgcaga tagaatgggc ttcagcaaaa tacaaactcg aacaacttcc 7920
atgtatagtc ccttaatttt ctttgctttt ttcatatttc atcaggctcc atgctgagcc 7980
caatcaggga cccgatagaa atccaaacac catgtcagcg agtccccaag aaatgcattt 8040
tgtgccaagg ctattcaagg aaggtttggg agcagctcaa gggcagacac tgttaccctc 8100
ccccaggtcc ccagtgcagg gcagtgttct gcatgtggag gcagtttggc ctaatggtta 8160
aggaggtagg ctctgatcgg gcctcctggg cacaaatccc agctccctgc tcactgtgag 8220
acctaagcca tattgtttag ctgcttggag agttttttgt catccacaac ttggagtatg 8280
atggtacctg tctcacgggt tgccatgggg ttcacacaag ctaacccggt actcactagg 8340
gccaagcaca tagtaactgc tcagtaaatg gcatcatcgg cggtgtcctg tggatgagtg 8400
cttgtgattg gctgaatgac cagaggggtc taaagatcct ggtgatggaa tcagttgtac 8460
agataaattg ttacactgag tagggatcaa gataggaaaa gtcggcaact acccagctcc 8520
cctgcaccaa actgggcaga agtggatcct ctgaaaattg cacacaccca tgtttaaatg 8580
tacacacaga actcttgcca caggcaagcg gagatttgtc atctgctgtc cctgcctcat 8640
cttcttcctg aaatccactc catgccagga ataaactgca tgctctccac cagcccaaac 8700
tgacctgcct tcccgccagc catcccgggc agggtgacct ggcttagtac atcgggttca 8760
gagatctttc cagtttactc gttgaataaa aagtgagggc tgatcgagaa agtaatggca 8820
gtcagggaag gcgaaggagg taaagaagag attttacaaa tgaagtaatt caacagagtg 8880
ctgacattgg taaactggca aacagatttc agggtggttg gttgagagta gagtagaaaa 8940
ggattaaata aagcaaactt gtggtgtact gaatcttagg aattccatgt atccaataag 9000
tatagtcatt tatgaattaa taaattcggc ctaagaagcc ttcttatcgc ttaaatcaag 9060
actaagtaac aatatatcag ttttaaaaag tcattatatc agaaaatcat ttaaatgata 9120
cacatagatt tccaagattt tactttaacc gaaactatat aaatgtgaat ttgttcaccc 9180
atcttttgac acagggctca ggtcttctct tggtgtctgg atcagccagt tgaaatttct 9240
tgtctgtttt gcctatgcca cattaataat gcactgtctg ggtcctccga tttcagtttg 9300
gattttgggt ttacattgtg gagtcatctg aatgcagaat ccttcaggga ttttactttt 9360
tttttttttt ttcatggtct ttaccatccc atttgatagt aaatattact cacctttatg 9420
aagtctttcc aaaacattca actaaatttt cttaaaatca ttgaatgatt tgaagagctt 9480
attcctcagc acttttactc catcagcttg caccttattt tttaatcttt ttttgagacg 9540
gagtctcgct ctatcgccca ggcttaagtg caatggcgcg atcttggctc actgcgacct 9600
ccacctcctg ggttcaagca attccgcctc agcctccgcc gtagccggga ctacaggtac 9660
acaccataat gctcggctga tttttgtatt tttgtaggga tggggtatcg ccatgttggc 9720
caggctggtc ccgaacttct gacccaagtg atccacccac ctcggcctcc caaagtgctg 9780
ggattacagg tgtgagccac cgcgcccggc cagcttgcac cttatttagg atatgtgatt 9840
attatagcaa gtctggtgta catacaagat tttgaatggg cacagatgac ctttagtaag 9900
tgcttggctg tgataagagg cagtcctgac tgcagatcag gctgtgtgga ccccagcctt 9960
gcatgtttac agaccttcat gtcttattct tacagggtat cagaagaaca cctactgggg 10020
aaacttataa attagtaaaa ggtgggcatt ctccccgccc atcttctgtc tgtctgccag 10080
gactagcaca gcactttgaa gtcattcaca tagaatccca acttaagagg gtaaaatcct 10140
cctcaacaga ctgaaaataa gtttaaattc cctttgctat attaactccc ctgaggaaag 10200
agtcttagat caatgtccaa cactaaaaac agttttaaat cagcaagtga gaattaaatc 10260
tgaagcaatt gataataatg tttcattcat tcctctcctt tggccccgtc caccctactg 10320
ctaaatccag gcatcaaaga gaagagggac ataattatct ctagtcccag ctgctggttt 10380
tccttccagc ctatggccca gttttctgtt ttactgagaa ggctggtgat gttatcttgg 10440
gatctaagtc tgcagtttca ccacaaaaag tccagggatg cactttcatg cttgtgtcct 10500
cctccctggg atagcaagga tattagaaga cccctggctc tgtaattgct tgtcatgtgc 10560
tctacagacg ccacagaatg ccaagaacga agtgctggga aggacaaatt catggaaccg 10620
tgggacggtg ctcctccccc agcgtaaagg acagctcctc ctcctgaatt ggagccagcg 10680
ttctaaatca tgtgtcaaca gagttgtcct ggatcggatc cagttctgcc attgatttgc 10740
aggtcatttc agtggtacct gtttccagtt gttcttaatt gaacagtggc accaaactat 10800
tgtcttgcct catccccctc ccatggcctg tcccccaaaa agagacttct tgggtaatta 10860
atcagggcaa catcaggcag tctgggcgcg gtggctcacg cctgtaatcc cagcactttg 10920
ggaggccgag gcgggcagat catgaggtta ggagattgag accatcctgg ctttgtgaaa 10980
ccccgtctct actaaaaata caaaaaatta gccgggcgtg gtggcgggcg cctgtagtcc 11040
cagctactcg agaggctgag gcaggggaat ggcgtgaacc cgggaggtgg aggttgcagt 11100
gagccgagat cgcaccactg cactctagcc tgggcgacag agctagactt cttctcaaaa 11160
aaaaaaaaaa aaaggaatct ctttggtttt atatattttt ttttatatat ataatatata 11220
ttaaaatata atatatatat ttatataata taatatataa atatattata tattatatat 11280
ttttatatat tatatattat atatattata tattatatat ttatatattt atatattata 11340
tatatttata tattatatat ttatatatat tatatattta tatataatat atattatata 11400
ttatatatta tatattatat attatatatt tatatatatt atatattata tatattatat 11460
attatatatt tatatattat atatttatat atattatata ttatatatta tatatttata 11520
tattatatat ttatatatta tatatattta tatatattat atattatata ttatatatgt 11580
atatattata tatgttatat attatatata tttatatata taatatattg tatatattat 11640
atatctaata tattatatat attatatata ttatatatta taatatatat tatatattat 11700
atatattttt atatatataa tatgtataat atataatata tataaaaaca tatataatat 11760
atattatata ttatatatat attatatata ttatatatat taaatatatt ttatatatat 11820
tatatatatt atatatatta aatatatttt atatatatta tatatatata cacatatata 11880
tatataaatg aggccaggct cggtggctca cacttgtaat cccagcactg tgggaggatc 11940
acttgaagcc aggagtctga gactagcctg ggcaacaaaa caagatcctg tctctacaaa 12000
aggaaactgt aaaaattagc tgggcatgat ggcatgtgtc tgtagcccta gctacttggg 12060
aggccgaagc aggaggatcg cttgagccca ggagttcaag gctacagtga gctatgattg 12120
tcccatagca ctccagcctg ggtaacacag caaggccctg tctctaaact tttttttttt 12180
aattctattt atatttacat gtatttaaat gtgaatattc actacctatt tgttgcatgc 12240
ctgcattttt tatactgggc ttgccaaaaa cccgaacagc tttctacttt gacaatgtat 12300
cagaatttaa atcagcaata tgttaataag ccaagcaaag gttatatatg caaataaaac 12360
tgttgtctat aacctcctgt tacactgggg cacagcaaaa gtcatggtgt agtcgcatgt 12420
gaacctgtcc ctttcatagc tgctcattgc caggaaacat caggaatagc catttggaag 12480
agtcatcagc cctcccacca tccgttttct gtcttgtctt ttccctatga gcaggggaaa 12540
ttccacgctg gccccaatcc ccagtgcagc ggctcagcct ctgcctctgc tgctggtccc 12600
catgaggcca gcttagaaac ggaggatttt gcagaacatc cctaaatccg cttgaataat 12660
gaagtgatca ttcataaact cacctgaacc ttattaaaac ctatttaata tttttcctgg 12720
ataatcctat agggataact tgcctcctgg gcttctctcc accgggttca gttcttcctt 12780
tagtggtgaa gttcctccct tcttagcatc tcaactgtgc ctgagaaaag gccagtggcg 12840
gctgcactct gttccctgtg gagtgttaat aaagactgaa taaattgaaa taaatccctt 12900
tcaatgtcat taagtgctat aaataatcat gaaccaatgt tcgatggctg atgagaaatg 12960
caagaaaaaa tttttaatca gtaggattca taagttgaca atctgggcca agttaaaaaa 13020
aataaaaata aaaagacttt taaaaagatc ttatcgtttg ttaccagtaa gactgaattc 13080
cagaagcaag ctactccctc atttgtgggc ccctgttatc actggctgct tagggttgcc 13140
aagccctgaa ttcatttgtc aactaagaga tttttggcca agattaagat ttcccatgcc 13200
tccatatttc catctgagaa atggagatta tactgtcttc cccctcagaa tggatgataa 13260
tgtggtctct cttctgttcg catagtcata gaactgaaat aaaacaactt aagagaattc 13320
ctttgagctt ctcagaagtg ctgcagggct gggggatgcc tcccaggagc cgcagtcagg 13380
tgctgatctg aagtctttgg tgggctgact ttagcctgac ctgaaatagt atagctgctg 13440
ccacctggct cccttagcgt cagtcagacg gtgcagctgg ttcctagggg tgagggctga 13500
gccagcaggg tccgtgccca ggagggatgc atgggtggcc acagcccagc ctgcactgat 13560
cttgtctgtc cccttctttg gaaggaagga gccccaaacc agggtgcaag acagtgggtg 13620
ggggtgcctt gagcatgacc tcaagtgatt tccagcccct gccagtgctg acttctctgg 13680
ggaagggctg ggacttcctt ctgggctcaa gtcacgaccc ttggatggaa tttcctggga 13740
gcttttctgt tttttctgga gttttcagtt ttttcctaac cagacaggga cttggtacag 13800
aatctcatat tctaattatg cctaggagca gcctctcccc accactcaca gtgtttagca 13860
tgtgacagga atcgattaag gcatgagtga ttaaattaaa gccaggcatt gacttggatg 13920
gtgtaatatt ctgacatctg tttggtgtca aaggcacggg gcaggcgcgt taattgaact 13980
gcttgcacct ggcatttgaa ttgagccaga gcggggctaa agtcagtttg ccttcaccct 14040
gtaaatggag ggtttctccg gagcgtggat ggtgggaggt atttcagggt gtatgcataa 14100
cccccaccct gacaatggcc catctcttct ccagcgtggc caggtttgag tgccagtcct 14160
gggtgtccag tggccccata gccttgcgtt ttagtaaaat gctgccccca ttaccacctg 14220
gtctgtgcac ttcggtcact ggaatttgcc atcttccagt cccgaatgtg gcaagccatg 14280
gagccttaag ctcttctccc tccacatcct ggaacagacc cgccagtttc ttccaggcat 14340
tgcctcagtt tgcccctctg tttccagtca cactctcacc agcgataaaa tgattttaga 14400
ccttatcatc tcaccctcgg atccttatgg aaacaataat gagttgttcc ctgtttcaat 14460
tccaaaattc atatccaatc cgttttgcat gccattgcca aattcctccc agagcaaccc 14520
cgtcacctgc cctggccctc tccaagtgtg gtcctgccat gggcatcgcc tgctaagcca 14580
agctggcctc gagctgcctg cccgggtccc cacaccttgg ctcacctccc tgcccagtcc 14640
cgcctcctgc cagcctgccc tgtggctcct tcatagatgc cgtgctcttt ctgccccttg 14700
ctcacccatg gcagccttgc ccctctctcc ctgccccacc ccctatttaa attgacctga 14760
ccttcctcag tgtccatctt ccccgaagct ttccccagcc ttggcactca aggtccagag 14820
gctacgcgtt tcctctcacc tgtggcagcg ccgtgctccc cagtgcctca cagtttcctt 14880
cttgcccccg cttcctgtgt aggactcatc tgcccacagg ttgcacgtcc tgtgagggca 14940
aggactgtgt cttatgtgac tttccttctc cagtcacaga gctgggcaca tagatagctc 15000
aaaaccctct ttattaacac agttggatgt tgagaaatca aacaggccaa tgtcaaatga 15060
gctctcctta tttaaatcaa gtcagttctc cacctcctag cactcagttc cagtactcta 15120
tatacatgga aataataaaa aacacatttc ctttgaaaca ttctataatc gttcctttgc 15180
cctacttcag accaacttaa cgcactcccc attggtccaa atgagttttg ctatacgaag 15240
atgctgataa taatagcagc agtggattat tctgctaaaa ccattgcctc gttaatcctc 15300
agtcccgagg tggggattat tatcctcatt ttgcagagaa gcaaactgag actcagagat 15360
ttcacagctg gggagggagc cagctcatcc ctctgtccag gcccaagctc tctcccgctt 15420
gccttcctgc ctctgcaacc tcagagcatc ccccatctgg ttctactgcc tgtgctagtc 15480
gtgcaggagc caaaagacac gtctttagtg ctaaggactg gagaagccat gccctccagc 15540
ctctgtgaat gggtcatatg taacatgagc ctggagaaat tatttgaaac caaaggcaag 15600
cctctaaacc aggctgctgc ttcatggcgc cggtgacggc agaaccaaat ttagtgctgt 15660
gggcaggtcc acacttatca aatagagaag ctcatttttc ttccggctca catcaagcat 15720
gaaaaatgtt cacacatacc ccccacacac acatgctttc cggaggggtc catgtggcta 15780
gaggctggaa gatgtggatg agaggagcct ggcaggtaag cccagggaag atgacattca 15840
gcttcccaga cagcatctac agggagaaat ttaattaaaa gtggggcggt ttccctgagc 15900
aaggcagaca aagtcagccc tctactgtta agaaaaaggg tcacagtgag aggggaggtg 15960
aggagactga gtctgtattt tctagtctgt tgggctacac tacctgatcc cccttcctca 16020
aaaatccact ttactttccc catgtctaca ccaatgtggt tcacactctg ggaccaggaa 16080
aagggggagt gatggggaac agagaaggga ggagctcaca cagctgaggc tggggttatg 16140
catatcgaat tacttagaat ttgcaacctc acagggtact ttcatggcgt tgaaatacac 16200
ttcccacagc caccctccct ctaactaaaa gcaagagtca tttctcagtt ctggtcttgc 16260
ctcccacgtt ctcctccaca tttaagaaaa tccaccagct acaaagtgaa gataccatat 16320
gtgatatccc accctagttt ctgttttatc agggtttgga gcaggtggag caggcagagg 16380
gatcatttca gcctataaat tgtattaagg gtgagtactg agtcattctt caagaaaagt 16440
tttagaagca tccaaaactg aagggtggag ccacctggag acagtatcat cagtcctggc 16500
cccgagcatg gcctgcatag gcccccatgg atcccagcgg gagctgcaga gtgcgggcac 16560
cttggcacac agccctgagt gcaaaattag gagctgggca gagggcatct ctctgtcgcc 16620
attgggcagc ccagggcaca ctggtcatag ccttagacca cgaacaccct gtgcccgggg 16680
gacagatgca accagtgtgc cctgggctgc ccaatggcaa cagagagatc gacacctgga 16740
ccccatgtca cggggactcc actactaagg ctcctaagac tgccaccttc cagtgggata 16800
agccctgcct cctactgggc ccacaatgtg cagagaacac ttgggactac ctggctttct 16860
ggatacacaa atattgatcc aatctggact aattagaagg tcagtcccaa taacaaatcg 16920
aagtcagctg ggcgtgatgg ctcactccta taatcccagc actttgggag gctgaggtgg 16980
gcagatcatt tgaagccaga agttcaagac cagcctgggc aacatagcaa aaccctgtct 17040
ctactaaaaa tacaaataat taggctgggt gtggtggctc atgcctgtaa tcccaacagt 17100
ttgggaggct gaggcaggtg gtcacctgag gtcaggagtt tgagaccagc ctggccaaca 17160
gggtgaaacc ccgtgtctac taaaaacata aaaattagcc aagcatgatg gcatgtgcct 17220
ataatcctgg ctactaggga ggctgagaca ggagagaatc gcttgaatcc aggaggtggt 17280
tgcagtgagc tgagatggtg ccactgcact ccagcctggt tgacagagca agactctgtc 17340
tcaaaaaaaa aaaaaaaaaa aaaaaaagcc atgcctggtg gagcactacg tgtaatctca 17400
gctatttggg aggctgaggc acgagaatca cttgaacctg ggaggcagtg gttgcagtga 17460
gctgagatcg cgccactgca ctccagcctg ggcgacagag tgagtgagac tccatttcaa 17520
aaaaataata aatctgagtc actttaatat tgttatttgg atgtcaacct ctaggtgttt 17580
gagacaggag agtgatatgg gggcactgga aacacacagg cacggggtgt cctcacactt 17640
gggtagccca cacgatgtga tttcagggtg ctgggaggtc cccccactcc ccaaattact 17700
aacaagtgga tagtacttta cagtttatat gatctcattt gattcttaac atgagcctgt 17760
gagtgaaaaa ttccttcccc tcttctacag attaggacgt tgagattcag ggaggttcag 17820
agggattcag ggaagtcaag tggcacctgg agtcccgtgg ctaatttgag gccggtaggg 17880
gattcgaacc caggatttgt gcttcttatg cctgggcttc tgctccctgg ggcatggtct 17940
tccccctagc tttcccattc actgctttag cctaggggtc ctacccttta ttaaactgcc 18000
agtgcctcac tgcttttctc ccccaaagac aaaaaaaaag tgtttttgct tttgttttgt 18060
ttttcatggg cagagacctg gaatttcagc ttgagaattt gtgccatatg ataaataaat 18120
caacagatgg ctttttcctt aaaaaaaaaa aaaaaaaaaa ctaagatgta tttgcagtga 18180
ggcataattt gtaccaaaaa gtgctcacca cactgtagtc atgggggcag gaggcagccg 18240
cgggtgaagg gagaaatctt ggagtccagg cagccccctt ctgggctgaa ctggggagct 18300
gggggtgctg ccagccctgc caggttctcc taggaggcgg cagctcatat ggctgtggga 18360
ggaggcagag ggagcctcat atgcacccac atttccaggg atctagaaga cagaaggagg 18420
aaaaccacca tcatgttaaa gcagacagtt aggtaacaca tcctgtaata caagttattt 18480
tttccacatc taaaggctaa aaatagttgt tagaatttaa agataattgg taaatgagtt 18540
tctatccttc tagtttcaca tcaaatggaa tcatgctgcc ttcacatcac tagtgcccgt 18600
tatttgtgtt taatttccac aatgttgtct aattccactc tttgggcttc cccagggatc 18660
cagcctccct cactcgccca tcgcagggag atgctttatt catctttgtg tcttctgtgc 18720
cgggcatagc gcatggcaca gaataagcac tcagtaattg attcacgagt gaataaatgg 18780
atgagtgggt gagttcaata ttgactacaa aaaccctaag gccacactgg tgagtggctg 18840
cgcctgtagt cccagctgct ggggaatctg aggcaggagg atctcttgag cccaggagtt 18900
tgaaactagc ctgggcgata tagcgagaac ctgtctcaaa tgacaaaaac agggccaggt 18960
gcagtggctc acgcctggaa tcccagcact ttaggaggcc aagatgggag gatcacttga 19020
ggccaggagt ccgagaccag cctgggcaac atagggagac cctgtctcta caaaaaattt 19080
tttaaaaatt agctgggcat ggcggtgtgc gcttgtagtc ccagctactc aggaggctga 19140
ggcaggagga tcacttgagc ccaggaaatt gaggctgcag cgagccatga tggcaccact 19200
gcactgcagc ctgggcgtca gaacgagacc tgctctcaaa aaaacaaaca aacaacaaaa 19260
aaaaaggctt tcttaaagag acttgagaac agaaagggga acagatacat aacttatata 19320
tttatttgtt catctttcca ccttcctgga gggtggaggg gaacaggtct gtatttggag 19380
ttttgaatgc taaaagtggg aatacatgta ctgtttgcca tgatctgttc aaaagttaag 19440
ccaaatgcct tagattctcc tgaaaactgg aatgccactg taaactataa gccccacttc 19500
aaagataaaa gatcttgatg aacagggctg ggtctgtgga ctgggcctct ccccaccaca 19560
caaggaaggg tggtgccagt tgaaggaaaa tcacttaaat ccttgctgtc tcctaataag 19620
gtgtggtccc aggtagggct gtcagaatta gcaaattaaa acacagggca tctgtgaaaa 19680
ttagaatttc agataacaac aaataattgg cataggctgc ataatgtccc tcaaagatat 19740
caggtcctaa tctccagaac ctgtaaatgt gatcttattt ggaaaagggg tctttgtaga 19800
tgtggttaaa ttaaggattt tgagatgggg ggattatcct gtattatcta ggtaggtcct 19860
aaatgcagtc acactcatcc ttgtaagagg aaggaagaga gagatggaaa acacagaaga 19920
gaagacaatg tggtgatgga ggcagagatt ggagtgaggt ggccacaagc caaggactgc 19980
tggcagctac cagcagccag aaaagtccag gaaccaattc tctcttggag ctccagaggg 20040
agtgtggccc tgctgacacc ttagcttcaa cctagtgatc ctgattttgg actttggcct 20100
tcagaagtgt gagggaatga atatctgttg ttttaagcca ccaagtttat ggtcatttcc 20160
tacagcagcc acaggaatca aaaacagtaa gtatgtccca tgcaatgttt gtgacacaca 20220
ccaaaaatat tacttgttgt tcacctgaaa ttcaaattta actgggtctc ctgtatttta 20280
tttggccaac ctagttccca ggcccaaaga aagaggcttt tgaaatttgc aagaaagctg 20340
gttggagctg tcagaaagtg gactttgtaa acacagtacc accgaaccaa tttgaactgt 20400
actacctcta gacaaaagag agggcagtca gacagttgtt cgtgatttct tctttcaaca 20460
gtcatttgag cacttactac aaaacagaag ctatgtgtaa gggtggaggc gttagctgtt 20520
aatcaggacc tccaggctaa gtttctgtat tagtccgttt tcacgctgct gataaagaca 20580
tacccgagac tggggaattt acaaaagaaa gaggtttaat tggacttaca gttccaagtg 20640
gctggggaag cctcacaatc atggcagaag gcaaggagga gcaagccaca tcttacatgg 20700
atggcagcag acagacaggg agagagagct tgtgcagggg aactcctctt tttaaaacca 20760
tcagatctcg ttagacttat tcactatcaa gagaacagca cagaaaagac ctgcccccat 20820
gattcagtta cttcccacca gatccctccc acaacatgtg ggaattcaag atgagatttg 20880
ttaccatatc agttaccaac ccttccagat aaatcacgtg aaatatcgcc attaacagag 20940
tgagctcagg tggttcttca gtgcatttct gatacctgaa ccttccctgg gaatttcaca 21000
gaccatcagg ctctccaccc tttgatagca ggatagcagg gcccaggttc tgcaggagga 21060
gatgttacca caggcctgaa agggagggag gggcagatgc tacaggaaga tgctggctct 21120
ggattcgctg gaggagcttt caagggaagt agatacacac tgtctccatc atttcatgtc 21180
catcacactc taaaatgctt tggacaagaa gcaaatgtta aagacaaatg tggcccattt 21240
tcctgtacaa agagggctgc tcccatgcca ggctattggc actggtgggc atgaggcttc 21300
tctgctgccc tggccggggg gttctctcac tcaccattgg ctctctgaca cctggagaga 21360
ccaccaccct tgggctttca tgatgctcac agaatccaca ctgttggagc tttaaggagc 21420
ctggatcaac tggaacaggc agggagtact aggacagccc agcattgccc caaaatatcc 21480
aggcctgata aaagagaaaa acaggtagct cacaggaaaa ggataaaaaa aggaggaggg 21540
atttaacatg aaaaggtgct tgatctccct cataataaaa agactgctga ttccatccag 21600
gcaagtgaca gaaaaaaaaa atttaattta aaaagactgc tgataaaacc acagcgagac 21660
actgctgctc agggatctga gggtgtgggc agccaggctg ccacgcatca tgggtcggag 21720
aggaagacca cacccctgga gcagagggcg gctgatctgt cagatgccct ttgacagcac 21780
ctcagcttcc aagaattaac cctttctatg tgagcagagg catccatggg gggacacact 21840
ggtgaatcat ctgttatgta gaagtctgga aaacatcagg atggaactgg tgaaataagt 21900
gtggcctctg acggaatgga gcggtccgtc tgcactgctg cgggtgcccc tcagatcctg 21960
tgggtcagtg agaaaagcag tgaggaacaa ggcaggtact gtgtactgtc ctctgcgtgc 22020
aaggaaggcc agcgcatgca acagagtcca cacagacata gcctaactct ggaaggaaga 22080
atgagaatgc agtttcagtg gtggcctctg gtggggagaa actgggtgaa gggagatgtc 22140
atttccattt ctctactatt aattttgtat taccatgctt aaatgttact ttttaccttt 22200
tttttttttt ttgagacagg gtctctctct gttgcccagg caggagtgca gtggtacaat 22260
catggttcac tgcagcctga acctcccagg ctcaagcaat cctcccacct cagcctcctg 22320
agtagctggg actataggca cgcataccac cgtgcccagc tatttttttt aatcaagatg 22380
gagtttttct atgttgccca ggctggtctc aagctcctgg actcaagcaa tcctcctgcc 22440
tcagcctccc aaagggctga gattaaaacg tgagtcaccc tgcccagcca attgcttttt 22500
aaaaaagatt aaatgcatgt atacgctcag gcatcagcac acttggaaag gatgaaaata 22560
tccggaagaa gggttctttt aaaaggctcc tcaagtgatg ctggcaggca tgacgaatgt 22620
ccctggtcac aaaagctctg atctggccta accctgtcat gttagagact ggagtgcgtg 22680
tgtgtgcgcg caaagtgtgg ggggatgggg gtgagtgtgt gtggtgtgta agcatgagtg 22740
tgtatgtgtg tggtgtgggg gtgtgtgctg tgtgagcgtg tgtgagtctg tgtgtgtagt 22800
gtgtgtgtga agtatgtggt gtgtatgtgt gacgtgaggt gtgtgtggtg tgtgagttgt 22860
gtatggtgtg tgcatgagca tgtgtgtggg catgtgatgt gtgtgtggtg tgtaagcatg 22920
tgtgagtgtg tatgtttgag catgtgtggt gtgttgtgat atgtgtgtgg tgtgtgagca 22980
tgtgtgtgtg atgtgtctgt gtgtggtgtg tgtgagcatg tgtgttgtgt gtgtggtgca 23040
tgtgtgtggc gtgtgagcgt gtgtgtgcat tgtgtctgtg agcatgtgtg agtgtgtgtg 23100
tgttcagcat atataaggca tgtaactgaa cacagcactt tagagggctc tcctggagtc 23160
agagggggtg ggtaggagga gaagggaggt gggctagtgt gctgaagtat ctactccttg 23220
tcatagtctg tgacaaccca gactagccca tgagccaccc tgttccctgc atttccaatg 23280
agacctcggt ggacatgttc cctgaggtga ggctgactga tgtcatttga cgatcttgat 23340
gccaaatcct tttatatcaa aaacaaccag aacactctct tttctcttag tgctttcacc 23400
cagatgacca catttcatcc tcccagccac tctgggccag gtggcactgc tggtttgaaa 23460
gggaggtctc ccctggagta acttccgtgg gcggattcac accctgccca cagtcctgtc 23520
ccagtcagcc caccatggtg gtctccggtt cctccagaat tcccgctttt cagctcatcc 23580
ccacattccc ggagggactg agagcgcagc cccagggccc tgctctttgg gggccgtctc 23640
tacacccaga gaagcagcaa ggcattccta ggtttctctt tcagatgcag aacttcagtg 23700
ttcagagatg ttcccactgg tcctgagagg gctcagttca gctttaatga ctgcgctgtt 23760
gcgtgtgctc tgcagagggc gggtggccca gcgtggctga ctgcagtttt cctgacgtgg 23820
agcccgagcc tgccccgctg tttattaatt aaggatcact ctgcttgcag aaccctgaac 23880
tccccagaac tgtgaggtgg gagaaccccg agaggccacc tggccccact tcccacctgc 23940
tgcccaaacc ccctctctgc cttcctgaca gtcaccccaa ctcccagtga tccccatcaa 24000
ccatctgaca aggggactga gagggaagag aaaggagggg cccaaagagg aaggtaaaac 24060
tgtcgggaac agcccccaaa tgtgtgacag ccttcagtgg agttgcccac tttccctttt 24120
ctcctccctg caggacctcc cttctcccca gtcctcccca acttctgagg ttacattgag 24180
aaaagtctgc agagaggtgc cagcatcaca aggtgttaag gaccacgagt ttggcatttt 24240
aacagatgcc agagccactt gagaaatgtg gtaactaagc ccagagaggt acagttaacc 24300
tccccagagt cacacagcag gttcatggca aagctggact agcacaggtg tccttcccct 24360
gcagatcccc ttctgtgccc cacatcacct ccctccagtg tctgggccac ctggagatgg 24420
gccctcagac tcacccggcc agaggtgcca tctcatggga gaggtctggc caggaagcat 24480
cgatatttga gatcccaaga aatgaagact tggcctgtca gatgacagac ttcggtcatg 24540
ggaacacgtg atctgtttta cacatgcgtc ccctcagcag cagctttcca gaacattccc 24600
actttcttct gtagtgagaa gaactctttc cctgcagcct cctgcccaac tcctccttca 24660
gtgtctttgc ttcagtgtct ttgataaacc attctgcttt gcagagtgcg agctctgcct 24720
tgcagggttc gcatctgcct gtgctgagta accaacgcta aggtcgagtg gtcggtcacc 24780
tctcataaga gctagggttg tctcatgctg atgactagga cttgccctca aggagaaaaa 24840
taaatcaaaa caaaagcaaa aacagcaaac atgcatctct taaagaaggc tctgagtcca 24900
ggtaaatttc cttccactga agcagccagg ctgaattcga attatctttg cccctgctta 24960
aaaactaatg caaattttcc tagagaatat ccactaattc ctggaggggg catgggcatt 25020
cctgatgccc atgagaggac catttgctct tccctcagta tgctaaataa cagaagcgac 25080
atttgttgct ggaaagtatc agtgaagtta ataaggtttt tcttgcccag ggtgagggaa 25140
cagttcccaa tgacaaatgc tgtatgggaa ggggctgtag aactgccagc ccctttggtc 25200
catccgtaaa gtgaactctg tggatcctgg aggattccag cgtctttttt tttttttctt 25260
tttttttaag acagagcctt gctgtcaccc aggctggagt gcagtggcac gatctcagtt 25320
cactgcaacc tccgcctccc gggttcaagc gattctcatg tctcggcctc ccgagcagca 25380
agactacagg tgcgcaccac catgcccgac taatttttgt attattagta gagacggggg 25440
tttcactctg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acccgcctca 25500
gcctcccaaa gtgctgggat tacaggcatg agccaccatg cccagccagc atctttcatt 25560
tttctgtctg ctttggccct ttcctctctc actgtcttcc ttttccattt ccaaagtcag 25620
tccatctcac tattagcaca aaaactgcta gagcgcttgt cattggtcat ctctccctgc 25680
acctggctgg tctgttcttg gccactgaag cgtttccccc agctgttgct ttaatcattt 25740
tattgttatt atgccttact taagaaatgg atatgagatg catttacctg tctcttcctg 25800
ccactctgca gagccagtaa gatgtggtgg aaagggccca ggctttggag gagggctggc 25860
tggggttgga tcttggctgc cccctactag ctgtgtgacc ttgggtaagt agctggacct 25920
ctctgagcct ggttcggaat catagcacct ctctttcagg gctgctgtaa ggaatagcag 25980
tggtgtgtat aaagcagagc gcacagccag caactggccc ctagccacac tgctgagcac 26040
ctactgtgat aagctgccat tgtggtgtgt gaagcaaagg ggaaacatgc ctgctgtagt 26100
gagcttcctg tagggcaggt tgtagaacca gaggtgggtt ccaaggttac aaagggactc 26160
ttagtgtatt agtctgttct cacattacta taaagaccta cctgagactg gatcatttat 26220
aaagaaaaga ggtttaattg gctcacattg gctgggtgcg gtggctcacg cctgtaatcc 26280
cagcattttg ggaggccaag gccggcggat cacttgaggt caggaatttg agaccagcct 26340
ggccaacatg gtgaaaccct gtctcttcta aaataaaata caaaaattag ctggccatgg 26400
tggtgtgcgc ctggaatccc agctactcag gaggctgagg tggaagaatt gcttgagccc 26460
gggaggtgga ggttgcagtg agccaagatc gccccactgc actctagcct gggcagcaga 26520
ctgagactct gtctcaataa aaaaaaaaaa aaagaaaaga aaaagaattg caagaaataa 26580
attattgttt atgagctata tggtctgtgg taccttgttg tgggactggg agtcttggcg 26640
tctccctgac cctgcctgtt gctgcagcac cgctcagccc tgcctgctcc ctacctgcct 26700
cccctcggcc tctcctgcct ccaccgggcc cctggtgcct cctctagaga cagtcctcct 26760
gggaccgatt gtgttctcac ttacacgagg catccaggac tacagataac cagaggaagg 26820
ggcgcccccc ccgcctgccc tcctccctgg catcctcacg ctgcagaggt cagagcctca 26880
tcccagcccc ttacctgccc ctactctgtg gagaaccgtg gtcagttcgc caggccggat 26940
ccacgaacgg ccttgtggaa gatggtgagc tcacacccag agctggctcc gatgaccctg 27000
tctcctttac atgtttctac cttcccctcc ctaccttccc ccactgctgg gcgcagagtg 27060
gaggcagatg aggtttaaag ctcagaaggg cttaaacggg ttggggcgca gtggctcatg 27120
cctgtaatcc cggcactttg ggaggccaag gcagaggatc acttgagccc aggagttcga 27180
gaccaacctg agcaacatag tgagaccgcg tctctacaaa aaataaaata aataaaatta 27240
gctttgcagg gtggcatgca cctgcagtcc ctgctactca gaaggctgag gtgggaggat 27300
cgcttgtgcc caggagtttg aggctgcagt gagctatgct ggcaccacag cactccagcc 27360
tgagtaacag aatgagatcc tgtctcaaaa caaacaaaca aacaaacaaa agaaggctta 27420
aagggggctc caggtgggct tggcagcaca aagctatgaa gttctatctt agacacaagt 27480
tctgttactg ggcctttgca ggctggcctg ggtacctggc tgccatagac agggaacctt 27540
ccagatgagc tgcaggcgtg gagcacagga gccagggtgc tcttcctggg ctctgtccac 27600
aggcagaacg tacacagtct ttgtacacgt ccggcggctc tggtgcctat ttttgtttgt 27660
gtttttcttt tgtttggggg gatggatttg gtttcccccg agccctctgt cctcctgtca 27720
cctggctggt gctcggcaat gttgaccagc tgcctggctg gagttggcag tggctaaggc 27780
tgtgacagct aacatgttcc tgagtcctct catttcttca ccataatgcc ctgttgagtt 27840
tgcagatact gtctctgttt ttatctcccg gggaaactga ggctcagagt ggctaggcca 27900
ccttcccatg gtccctcagc tcatgagggc cacacagggc attgcggtgg ccttctcctc 27960
agccttgacc ctccggcccc agcattgctg cctcaagggg tctcctctgc tgagccgtgc 28020
accttctgcc tggcagctcc aactctgtgg ctgtgttcag tggctcagca ctgccccttg 28080
accctccctg gccttctgcg gatgccagac tggagcactc tgacaaggtc tggggtggtt 28140
gtatgggtcc tgtgacctct atacacctcc cagtgcctgg gaatcctgca gatacaccct 28200
ccttagccgt ccctaaccat agaggacatt tctgaggtcc ccgagagagt ggggcacccc 28260
tgcaggatcc aactgctggg cccaggaagg atagcagcag catgaggggt tccattagcc 28320
acaaactcac ggcatggaac cttcacccac ctcgcccctc atctgctgtt tagcacctgg 28380
cacgccgtgt atacttactg attattacat tttaatggca aattatagtg gcaaacgtat 28440
gcatctttgc acaattgttg tacagcatga tgaacaagtc attaatagta aagaataaat 28500
gtgaaagtga gaaaaatctg actgccaaag tttttactcc ttccttccct ccccagactt 28560
ttaaatgaaa gtttagggat aatcccttag ttgtcctgct agtaggactt gcaattaaaa 28620
gaattgggcc aagaacactt ctacgcttct ccttttaggt ttgggtgtaa attcggggta 28680
tttctcactg atgaaagcct ggtgcagggc agaccgtggg aagctttcat ttccggaatg 28740
gaccatcaac atcccttgga gaagaattct cttctccaga cccagacctg gtgtcctggc 28800
acccattggg caagtgggtc ctagaagaca aacctggtca gagcctggag gctgcttagc 28860
attccccacg cacattagca gctcggagag ctcaggaagc cgcagcccct ccttgcctca 28920
ccagcctgga tcaggacagc atcccctgga agacacacag ggcctggcct ctgattaccc 28980
agcctggagg gaaagctcaa tcgagcatca tgtcacccgg tgcccccatg cagggtggca 29040
ctggtgagac ccccaagcca atgataccac ctcacaggag tgcaggccca ttgtggccag 29100
atcatcttga cttttcaaga taaatcagaa atcgtatttc catgagatat ccctatttgc 29160
aagtgatggt gactaaatta gaagtttttg aatattgtaa catgttcgta ggctgtttgt 29220
ctggtttaaa ctctatctgg aggaattcaa gctagacttc aggaataact tcttgaggca 29280
aggattttga gaccttaggg aaagaaggac gtcttggggg tattctgact gttgtcctcc 29340
tggaagggaa gaacagagaa ctagaagact gcccttagcg aagttcaaag cacctaagcc 29400
cgggaccctc agcaagtgtt cttgagtcac agattctccc tgaggcgcct ctttctggct 29460
ccatagaatg gctgattctg taactcggtg agtttgcttt ttttttttcc tccatcaccc 29520
aggctggagt gcagtgaagc tggagtgccg tggagcgatc actgcaacct ctgtctccca 29580
ggttcaagca attctccttc ctcagcctcc caagtagctg ggattacaag catgcagcac 29640
cacacctggc taatttttgt gtttttaata gagacggccc gaagtgctag gattacaggc 29700
atgagccacc gcggccagcc ataactctgt gactcttgtt acaaaggcct tatattttgc 29760
tctttgaggg tggttttggt ttgatgcctg ttggttgcca tcttttaact agggatgttt 29820
tatcaaaatg cccagccaaa gtgtccaaac aaattatacc ttaaagtttg aaaatgtctg 29880
gcacttctaa ttcaatgcct gttgtgccag gcactgggct gctgaggaac tgagtcccgt 29940
ccctgcaggc tagctagaga acacacacac acacacacac acacacacac acagagtggt 30000
cttacaagtc agttttatat tctacctata tgcaataaag gtattattat gttgaggtgc 30060
cttgatataa aaatttttct taaaggagag gatgcctaaa acaggcatta cctgaaacct 30120
cctctctcca gcattggttg tcttctgtca tgactcaggg ttttcactga gaatgggatg 30180
gaaatgtggt ctaaagatag ggccaatgtt gggactggat cccctctggg aagtcagacc 30240
aggctagggc aggtccttga agccatcagg aaaagcctct ggagccagaa acaaaacaaa 30300
aaaaaaatgg tgttaactaa actcagtctc aaatcctgaa taggactcaa gtcaagcaaa 30360
ataattaaag gagttagcaa agggcaagtc agagagaccg agcaacacca atgtcttccg 30420
ggagccctgt ggcgagtgac agagcctgga ctctggagta gaactcatct tgtgtcttct 30480
tctgccactc gttagctggg tgaccttgag ccaagcccct taacctcttg gaccctatgt 30540
tcttatctct aagtaggggc tggtaatatc ttcccctttg aggaatgccc tctaaggggt 30600
gttgtgaaga ttcggtaagg tggcaggggt aggactcctg gccagaaaca ggcacataat 30660
aaatgctaag tctctccttc tctccacctg ctggatgctg tagatactaa ggatttcgat 30720
gtgaatgaga caaaacccct gccttccagg agcctttgag aatcagagaa ctagacccat 30780
ttccagaaca aggggatgca gggtctggat aaagttttgg ggatcaatag agcagagggc 30840
tcccagagga tcccataggg ttgactccta actcaagggc atgagacaac ccccaggaag 30900
ggcaccctgg aaggggtccg gctgtccctg atttacttgt gggcactggg ggaatgcccg 30960
gagccatcca gccctcaggg ctctgtgtga ttctgggttc ctcccataaa agataatcag 31020
attctttcac gttaatgtct ttctccacct cattgcacat catgcagcta ttcattgact 31080
cagcaagtat cagctttgca tgcgaccttg gcctacccac tttagctttt agtaatagct 31140
cccttcttga ataatacaac cagtggggaa acagaaccta actcttacct ctgggaggct 31200
tatttgcttt gagaacatat gtcctgcagt tttgttcata tggcagtgaa gtttcgtgca 31260
cacactctag agccaggcag cctgggttca aagcgcagct ctgccaggtc ctaactgcat 31320
gaatttgggc aagtcgctca acctctccat gcctgagttt cctcatctgt aagattggag 31380
caatggtaat acctgctttt tagggttgag aagagaatta aatgaattaa gatgggtaaa 31440
gtgcttagag tggagctttg caagtagtaa gtgctatgta agtgttcgat ttaaaatgaa 31500
agacccttaa atacattctt tgttcatttc acaagccctt catttcacaa ccttacattt 31560
cacaaccaag ctctgtctcc cctggaatcc agccataact ctgctcacaa gtgtgagaca 31620
ggccccagca gagctgcacg aagaggagag aaggcagccc cccagactcc caaccccctg 31680
tccaagatgg caaaaccaga acacagcctc tgtaccaccc cagcaggtat tcagaatctg 31740
caatctccaa agcccacttc aattgtaaat gtagagccac gtgcgcttta agtcacctgt 31800
cactctggag gctcttttgc tcagttcctc accattagca gggatgacag ggagtgcagg 31860
agtgcggtcg actcccagat attggagagc gctgggctag ctgcccattc tcccggcctc 31920
cactcctctt tgctgtccag ccatcacttg ctctttgaag gcaaacaaaa cagaaaacag 31980
tgccaaaagt atgggaagaa agccagcttc tcccctgggg tgcctgtgat gccatgccca 32040
ccctccctga ccacgcagcc cctgtggacc ctcagggccc caagccccca tttccatcac 32100
atgcgtacac ccatgtgtgt ccatagccgc ccatctcagt caataaggct gctcctgccc 32160
acttggaata gtggtgacaa ccaggagtgg cttatgggaa ctatcccaat ggcctgacag 32220
catgtccgct gcaaaccgct gaggtaggac actgccctca tgtctagctg atcagcaaga 32280
ggcgcagttg ctttcttagg taacattgct gctgtgtcct ggccattgct ggggggtggc 32340
acttaatcta caccagattt ttccctcctg tatcttccaa gctgcttgga tcttggtgct 32400
gaattaggtt ggactttgtc ttgtggggaa gggaggacta tagaccctca acgtaagcaa 32460
tggtcagact attctaagaa aactcgccga attaaagcat gaggtaaatt tagttctgac 32520
ttctgtccac cccactgcca ctgtcccctt ttatcccatg atcccttgct tttcttttcc 32580
tcctctctcc ctatctcttg tgtttgacgc atgataggaa ttcagaaata tatgtttgtg 32640
gatttgttta ttcacgtagc aaaccatttc ttgagtgcct accatgggcc aggtagaatg 32700
ggcggccccg ggctgcagtg gtttcttcag cccctctcca gggtttacac tgtgcaagac 32760
ggtttgtgat gggtcctccc atcgaggacc acactcttct ttctctgtgc cccttggtcc 32820
tcagtctctg accccacttc aaaggcagca ttcactcagg gaagctccca tacaatgcta 32880
gtcagagtaa aagtttggac aaattgccag gaagcagctt gtcagtatgc ataaacagcc 32940
tttaaaatat tactactctt tgacccagaa tttcacttct aggaatctgt cctaaggaag 33000
tagtcacatg caaaagattt atgtaccaag atgttcatca aagtgttgtt ttataacagg 33060
aagtctcaga agctggataa atatccaacc tctggaaatg gttagataga atagtatgta 33120
gccattagaa aattatgtct atggggttta aaatgtcatg ggaaaacact tctgacataa 33180
aagagcatga gaactgtata tttagcataa tcttaactat gttttagaat gcacaggaaa 33240
aaaatgtaca aacatattca tagtgatgtc tctggtggta ggattatgat cagtaagtac 33300
ttctgtctct tcatattttc ctgtatttga taatacatgc atatgttgtt tttaaaataa 33360
gaaaaatttt aagtttaaaa ttggagctga aaagtgtttt taggtcaggc gaggtggctc 33420
acacctgtaa tagcaccact ttgggaggct gaggcagtca gatcacttga gcccaggagt 33480
tcgagaccag cctggccaac atggtgaaac cccatctcta ctaaaaataa aaaaattagc 33540
catgtgtggt ggcacacatc tgtaatccca gctacttggg aggctgaggc atgagaattg 33600
cttgaaccca ggaggtggag gttgcagtga gccaagatcg tgccactgca ctctagtctg 33660
ggcaacagag taagactcta tgtcaaagaa aaaaaaaaaa gaaaagcctt tttaaacagt 33720
agcagacata actatataat ccttactaag ctgtcggtca aatttttatt tatatattta 33780
ttttattcat ttattatttt tagacagggt ctcactctgt tgcccaggct ggagtacagt 33840
ggcgtgatca tggctctctt caaacttgac ctcccgggct caagtgatcc tcccatctta 33900
gcctcccaag tagatgggac cacaggtgca taccaccaca cctggctaat tttttttatt 33960
ttttattttt agagatggtg tttactatgt tgcccaggct agtctcaaac tcctgggctc 34020
aagctatcct cccacctcgg cctcccgaag tgctggggtt accagcatga gccactgtac 34080
ccagccctca aatttttaaa aatctataag agacattatt ggacaattag agaaattcac 34140
atatggactt ataatagtat cagagtgtgt ggtgtgatgg ttctggaggg aatggacttt 34200
ttctttggag acaggctttt ctatgcccac ccttttatct tgctaactta tcatcatcca 34260
ggttccagca gaaacattac ttcccccagg aaatttctta agggtgcagt atcatgatgt 34320
ctgcagcaaa ttctcaaata gctcaggaaa aaagtacgtg tgtggtatga gtgtgtgtat 34380
gtatgtgtgt atatatatac acatatatac acatatatat acatatatgt gtatatatat 34440
acatatatgt gtatatatat acacacacat acacatatat atacacacac acatacatac 34500
atgtattttt atataattat atatgcagag agtgcaaatg ttgccaagtt aaagattggt 34560
gagtctaggt gaagggaata tggtatttat tgtattattt gtgcaacttt tcttaagttt 34620
gaaaattttc aaaacaaaaa attggaggaa gaaggcatgc cagtctaccc caagccctcc 34680
attggaatgc tgaaaatcta aacaatgtga tttggcaatt tcatttcttt tctgttgtgg 34740
gccagtagtc cttagatgtt ggggaagggg gtagtcgctg aggtgtggtt gacttaggat 34800
ggaagaagca gaagtcaaga ctcccagggt caaagtggtt tgctctgctg acccaagtgt 34860
gggaggccca gagtcagcgt ttcaggtgtg ctaattcagc atggttctat tcacggccaa 34920
agtccaccct gggcacctct ctggcagcaa tcttgggtga ctctactaag gccaggcctc 34980
catgacccta tgtctggatc ccatatctcc acctctccca ctgtctcagg aacggtgctt 35040
agctttttct tttccctctc ctgtcttctt tgccagcatg tagaaagttt aaataattcc 35100
cctctttaca acaaaacaaa acataccccc ttcagtcaac caccctagct ctcttctcct 35160
tttcccagcc agattttttt aaaagcatcc taggccaggc gcggtgactc acgcctgtaa 35220
ttccagcact ttgggaggcc aaggtgggtg gatcacaagg tcaggagatc gagaccatcc 35280
tggctaacat ggtgaaaccc catctctact aaaaatacaa aaaagtagcc gggagtggtg 35340
gcaggtgcct gtagtcccag ctactcggga ggctgaggca ggagaatggc gtgaacctgg 35400
taggcggagg ttgcagtgag ccgagatggc gccactgcac tccagcctgg gtgacagagt 35460
gagactccgt ctcaggaaaa aaaaaaaaaa aaaaaaaaaa agcatcctca gcactttggc 35520
aactccatct cctcccaaca tgtccctgtt actggaatcc agccaggact cagccccgat 35580
ctttctactc taaccagttg tctcagttaa caaggacagg tttatgctgc agtgacaaac 35640
aagatcccaa attcttgtgg cttcacacat ctggcaccac ctcatcttcc agccttagga 35700
gtcatctttt agttccttga aaactcttta cagttttctg ttggggcctt gtcatatact 35760
attcccctgg aatgttcttt cctatcccct ccctttcacc ttgctaactt gtgcccatcc 35820
ttcaggtctc agcagaaaca tcacttcctt ggggaagttt tctccaacac ccacactaca 35880
caggtgtccc atctacactc ctatgacttt gtggtacttg tctcacttca ttttccactg 35940
ccttccccac aaggcacctg cacaagggca aggaccgtac cactgtacct atgtcactca 36000
ttgctgtggt cacctgcact ctggctgcct accttaacta cacattagaa tcacctgagg 36060
agcttttaaa gccacaatgc aagactccac cctaggccaa ttggatccaa atccctgggg 36120
tagggccaga catcagtgga gttatatata catatatata ttttgtttgt ttgtttgttt 36180
gttttttgag acagagtttt gctctgtcac ccaggctgga gtgcagtggc gcgatcttgg 36240
ctcactgcaa gctccgcctc tcgggttcac accattctcc tgcctcagcc tcctgagtgg 36300
ctggaactac aagtgctcgc caccacgccc agctaatttt tttgtgtttt tagtagagat 36360
ggggtttcac cgtgttagcc aggatggtct cgatctcctg acctcatgat ctgcctgcct 36420
catcagcctc ccagagtgct gggattacag gcatgagcca ctgcacccgg ccatcagtgg 36480
atatattttt aaagcactgc agagaattct gttgcatcag cttgagaacc actgatctgc 36540
cttgtgcttc acatttaaaa ctttttttta atgaataaat aaaccccaaa aaattaatct 36600
ccctaagcct ccctagaaga taggatggta aggatatttt cctaggtaaa aatatgttaa 36660
tttcatattt catgaaattt catgtttcat ttcaatcaag ctctgtcata caccttacat 36720
ggggcaagcc cagtgcctgg gcagggtgta attatactca ttacacaggc aaggaaaagt 36780
cacattaggt gatggagcac aaataggcag ttaatggttt cagggctagt taggatatgt 36840
ttgtctttca attgcaagta atagaagccc aaagaaattg gttatttata taatataatt 36900
gattggttcc caaatttgaa aaattcagga atagacccag cttaggtaca gctggatcca 36960
gtcactcaaa caatgtcaca aagaaccctt tgacaggaat gtatcctgtg ttgactctac 37020
tttgctctga gtagtctttc cccaggtgat gataaaaatg gtcatcatcg ccaggcttgt 37080
gtcctgttta gtaggaatat acaagaagag ctcagtaaat gctggcccca ccactaagca 37140
aaaacaaaac ttttgttgtt gttattgttg ttttaaataa cagcttagac ctttcttctt 37200
tccttgttat tctctttcat ctgtaatcca gttttctact tctgaagtat agaatgttct 37260
gatgatttat tcttcattac ccacaacttg cacatgttta tttaaaaatg ccaggattgc 37320
ctggccgttg tgtgctgtta acctttgttt gctgttagtg gatccctgaa gttcaggctc 37380
ccaggggagc agataatggg tatccagttc ctgcaatatc caccctctgg caagccaagt 37440
tccttcctgg gtaaggtttt gcctacctgc attcctaggg aagtttctgg gcctgaccac 37500
caagccagct ctgagaaggg gtgcataagc cccaccatgc tttggctctg tccctataga 37560
atattttatg ttgttactga aaactaaagg aagatgggtg cggtggctca tgcctgtaat 37620
cccagcactt tgggaggcca agacagattg atcactcgat gccaggagtt caagaccagc 37680
ctggccaaca tggtgaaacc ttgtctctac aaaaacaaaa caaaacaaaa attagccggg 37740
tatggtggca tgcacctgtg gtaccagcta ctcaagaggc tgaggcacaa gaatctcttg 37800
aacctgggag gtagaggttg cagtgagccg agatcgcact actgcattcc agcctgggtg 37860
acagagcaag attctgtctc caaaaaaaaa aaaaaaaaga aaaggaaagc taaaggagag 37920
agactaaaat gatatcaggt tcctggagaa caaacagaca tgattttgct tcatggcagg 37980
acagccggaa gaagtgggat tatatcctca cattacaaat aagaaaactg agactcagaa 38040
tggttaagtc acttgtccca ggccacacag ccagtaaatt acagaaacag aatttgaacc 38100
caaatcttcc agctccaaag cttgtgttct tttcactacc tcctgcttaa ttttttaatt 38160
tctaagatta gacccttcat ctatccatga cacctgcctg tcatcccctg aaaaaaggtg 38220
aacgccgttc agaaattttt ctagcctgag ctcactccca gttcacttat ttttgctttg 38280
tcatggctgc ccagtcccca cttgtagacc aggaataggt catggctgcg gggactacac 38340
gctgtcgctg ctgcaagggc cggcctctgt ttccggggct gagtgggggc cagacctgcc 38400
aggagcacca tcttctgtgg gtcctgcctg gatgtcacat cccggcccca agaagtcact 38460
gcaaaccttc gtattattga gcttcacatc ctagaatttg ctgtcactgt ggctgctgca 38520
tgaagttgtc ctgagagaaa cgggcattgt cattaacagg gaaattgatg gtctggggga 38580
aaagtcatcc tcattctctt gcagatctat gggtgattga gactggctga tgttgaaggg 38640
gtttctcagc catcgtgtgc catgttatgg aacagtggtg tagccagcca tttgacaccc 38700
agcgctgacc tttgtttaac aacctcacct atatatgaca aaatgattgt cagaaataat 38760
cgtgtaatga aatgactgta ataatggcca gaaaagaaac gcagatagta aaatgtttct 38820
cttgttgaac tctgtacata taattgcacc aggatttttt tcaaataaaa agtaaatatt 38880
atactacaaa aaagggaaaa agcacaagca tttattaaat agctttctat atctttctga 38940
gttttgatcc tttgattgca gactgatgta atattttatg taaatcattg cttggttact 39000
aagtgaactt taagaaaagt gagacgtctg cagaagttgc ccataattta gcagctactg 39060
tattgtacca ttgatgtacg gctttatttt cttgattaat tatttaaaca atataattca 39120
caattttaaa ataataaatt tccacttaaa atggtattta aactcagcaa aatatatcat 39180
ctatgagtaa aatttgtatt taccaagcaa aaatattaca gtttgtggtt cacatgctgt 39240
ctcactgttt taaattttaa atacaaaaac tccaagtagg ctgggtgtgg tggctcacac 39300
ctgtaatccc agtactttgg gaggctgagg caggcatatc gcttgagttc aggagttcaa 39360
gatttgcctg ggcaacatag tgagatcctg tctctactga aaacaattag ctgggtgtgg 39420
tggcacatgc ctgcggtccc agctactcag gaggctgaga taggaggatc acttgaaccc 39480
tgggggacag aggttgcagt gaggcaagat tgcaccactg cactccagcc tgggtgacag 39540
attgagaccc tgtctcaaaa aaagaaaaaa aaaaaagaaa cacaaaaact ccaggtggtc 39600
gcacagaatg acaggactga agtaacttag ctccaatttc tgtcttcata atcactgtcc 39660
taccattgtc tgtgcttaga atctacttgc ttaatgcagg aacatgtgtt ctcacagaga 39720
tggaaaatgc aaatggcgcc agaagcaagc tggaaattct gaaccattaa gaatttactc 39780
tctgccaggc acggtggctc acgcctgtaa tcccaggact ttgggaggct gaggcaggca 39840
gatcatctga ggtcaggagt tcaagaccag cctggccaac atggtgaaac ttcatctcta 39900
caaaaataca aaaattagcc aggcatgatg gtgggtgcct gtaatcccag ctactcggga 39960
ggctgaggca ggagaatcgc ttgcacctga gaggtggagg ttgcagtgag ccgagatcta 40020
tctgcaccat tgcacttcag cctgggagac agagtaagac tccatctcaa aaaaaaaaaa 40080
aaaaaaaaag aacttactct caaaataaat acgtgtggct gactccacat atggtagggc 40140
caactgtata actagaagtt ctccaaataa cttctgtgga gaaaaaaaag tttattaaag 40200
gttaactttt ttaaagtgct aactagaacc ttactaacac tgagatcgca ccaattgttt 40260
ataacttaga cagggccggg tgcagtggct catgcctata atcccaacac tttgggaggc 40320
cgaggcaggt ggatcacttg atgtcaggag ttcgagacca gcctaaccaa catgatgaaa 40380
ccccatctct actaaaaata caaaaattag ccaggcacgg tggtacacgc ctgtaatccc 40440
agctactggg gagggtgagg caggagaatc tcttgaaccc aggaggcgga gattgcagtg 40500
ggccaagatc gcaccattgc actctagccc cagcaacaag agtgaaactc tgtttcaaac 40560
aaacaaacaa aaaaaaaaac ctcttggacc aggaaaatat tttttaaggg aggagtattt 40620
tatcactggc attgtttagg attgcaggca catgatgcta atgaaaagca gactaactat 40680
tagttggttt tattactgtt tttgaactct ctctctccct tttttttttt tttgagacag 40740
agtctctctc tctgtcaccc aggctggaat gcagtgactg cagtctcagc tcactacatc 40800
ctctgcctcc tcagttcaag tgattctcgt gcctcagcct cccgagtagc tgggattaca 40860
gggcaccaca ccaggctaag tttttgtatt tttagtagag gcagggtttc accatgttgc 40920
ccaggctggt ctcaaactcc tggcctcaag cgatctgccc atcttgacct cccaaagtgt 40980
tgggattaca ggcgtgagcc accgtgccta gccctgtttt tgaactctct agagacagtc 41040
cagcccctta ttacttgtcc tgaggcagct gctcccttca cctggccccc cgcattgtgt 41100
tccggaccct tgtcctggtg gtgctaaaga atatctctgt cgatcctttg gggactgggg 41160
aaactgaggc ccagtgccac gcgatgccat ttgttcaggg aagattaggt catctgctag 41220
gtccccagtc acttgacctt cttcccagac aggaagaagc tgctctgggt ctctcagtgc 41280
tccacgtgtc tttgcacatt gaaatgtttt ctgatttttt tttttttttt tttgctgtta 41340
catttacttt taaaaaataa caagcaataa aatgttacat ttgagaaggt tgaaatgaga 41400
attgatttga gttaaattct agcagatttt tcttagaaga atgatatcat catctccagc 41460
tacctgcaat tgatctactc tgaattaaga aagagacttc catttgttgt ttatattttg 41520
cactcttgat gtgtttcttt aaattatggt catgggccag gtgtaggagc tcacacctgt 41580
aatcccagca ccttgggact ctgaggaggg aggatcactg gaggccagga gttcaagacc 41640
tcgtctgtac agtaaatttt aaaaattagc caggcatggt agcattcacc tgtagtctta 41700
gctacttggg aggctgagat gggaggattg cttgagccag aactttgagg ctacagtgag 41760
ttattttcac gccactgccc tctagcctgg ctgacagagc aagacctgcc tcaaaaaaat 41820
aagtaaaaaa taaattaaat ttcaatcatt agcagtcatt aggatattta aatacagtat 41880
gttgaatcaa agttacgcat gtgtgtattt ttttttccag agagttgttt atcatgtggg 41940
ttttaattta actttaaaaa aatgttggct ggacagttgc ccaaatggta tcatcagcca 42000
tttggttgag aacgtatgtc ctgcgggctc ctctgtcact ggagttttgc tagctgacag 42060
ccactggcta gttagagact gcagtcagca cagatgcagg cgtggacttg cgcacgtaac 42120
catgtcaatg caaagccatc acttcttaaa aattctgaac cctgctgtct gagatggtgg 42180
tgcagcggat agaactctgc tctaagaggc agtagctaat tccatgtctt ctttgccctt 42240
gactagctga gtgactttgc acatggggct tgcctctctg ttgccttgtc tgcaaagtgg 42300
aatcatcttt tccttgctag acagaaggtg gaccctggac ctatggcctt tttgagtttc 42360
ccccccgctt cttagaagga cctctgatcc tactgagttt aatacccacg ggttaataat 42420
tgggaaaagc aaaggaagcg cttctgttta ggtaattata tgcatgtttt tgtctttttc 42480
tggctggaaa gatatccaag ccactgggaa ggtccgtggc tacccagggt agccctctct 42540
ggggagggct gctatatcca agagcccctc atgagaattt gaaaatcgac catggtaggg 42600
cctgctgact tttgacagct aatggtgtgc tgagaattgt ccctccaaag atgcctttcc 42660
attccctcgg gagagtctgg gcagccccta ctgggggctg ggatgctggc tcttccctca 42720
gcctccaccc caactgctct cttccctcct cccctcccca gccccctaat ttctctcaca 42780
aggctttgtt ctgcagcaac ctttcctaat gcagtcctgg cctcttcgca gcttcattac 42840
ataaccttcc gtggactcct ggtccaagga tcaccccaga aagccagtca gaggtaggca 42900
cgcagctggg gtccatttac ttaccttccc caccccctcg gaactcagag gtggtgcagg 42960
aatttggact ccaagaatta acagctccac caccatcacc agagccaaaa ctcaggatgc 43020
atgtgcttca tctgctgctt atttccagct gagagccagt ggtgccatgg ttccttaggg 43080
agccggtccc ctgatgccgg ctcctggccc caaatctctc tgatccgggc tcttccagaa 43140
tgtcttgtct ccaccatcgc ctttgaccaa tggtgtccct ttgcctggta atgtcccctt 43200
tgcctgatga tggccctgtc actcctctct ttagcacaga ggaggctgtt tcatcccttc 43260
aagcctgccc tcccttcaag tcttagctca agttcacctt ctccgcagag ccttctccaa 43320
tcttcttgac tacgtctcct ctcagctcca gcaacctctg tctctggcac tgattcctta 43380
cttagctaag agaatcacag acacttgggg ctcaggacaa tctgctttct ctcttcttac 43440
ccatggcctt ggactgtgtg tacctctttg tctccactcc caaacccaac ccccagaggg 43500
cagagagcat gttgtctgtc cctttgctca gcatgaagcc atgcgtgtgg tagatcggca 43560
gagttccata acttgtgttg accgaggggt cactttgctc tgaaattacc cctgtgtcct 43620
tcagtatttg cacagatagc ttcctggcca gaccgaatat atccaagggc atggcccacc 43680
tctgctcctg tttccaggtc cctggtgggg gttagttcat gccttcctca taatctgccc 43740
actggcctgg tcctcaaggt cttcccaact gctcagccag agttgagaaa atgggtcgct 43800
ccatcctgtt tgtgtcgttc tctccttcct ggcccactct cctgcccaca ggtatccagg 43860
ggctgcctgt agcattagag gacatacatg cacatgcgtg ggcatgggac actcacgtag 43920
cctccaagca cagcatcaat aatgcattct gtgctttata gcatggaaag ctgctctaaa 43980
ctttattaca cagtggacat gtctgaagca gctcccaaat ccacccctga gtgtgttgga 44040
attggcaagc ctatcacttg ggagtctagt ttttttgttc gttaataata gatgcttcct 44100
gtggccccag cttggcaatt ttgatttaaa gtgatcttaa ctgaagagac taatggacgg 44160
gtctgaattt gtgcctttta agcacaaagt attgctctta attaactgga ttctatcctt 44220
tgagcaggca gaggccttcc cccaagggcg tcattaacga tccacatctg gacatcttcc 44280
aaagccttct tctgtttcag gccaaccgca ggtgtgttcc tgaacaccca ggaggctatg 44340
agagccacat atgcctccca aatacacaca gtgtgcatgc ccagggacat agagcagtgt 44400
gcaaagtccc attccatctc tctccacctg ggagaggatg gctcttctgt ctgattcatg 44460
gctcaaagtg gtaaaggagc tccccactcc ccgtcccacg cctactcaga gtctgcaaat 44520
atgtatgcga tatgagagct cgtcagttag ctgtcttcag tgtggcgcac atttgaggag 44580
tctgactccc ctccagcaca ggccaatgtg cactgctctc ctatctttgt acccccactg 44640
ttgcactgtg cagaggttgg agccatagaa gtaccagagc tgtgaaagga gaggccccct 44700
ctcacctctg ccctggtctc catccccact ttctctagga agctagtagg tgctgacagg 44760
ggagagaagg gaggggaggg gtccagaaac agtggctcat gcctgcaatc ctagcacttt 44820
gggaggctga ggcaggagga tcatttgagg tcaggagttt gagaccagcc tgggcaatgt 44880
agcaagaccc tatctctaca aaaagaaaaa atgtaattag ctgggtgtgg tggtgggcac 44940
ctgtagtcct agctacttgg gaggatgagg tgggaggatt gcttgagccc aagagtttga 45000
ggttacagta agctgtgatt gcaccactgc actccagcct gggcaacaga gctgagaccc 45060
tatctcaaaa aaagaaaaaa aaaaagaaag gagagagaga gaaagaaaag aaaagaaaaa 45120
aaaaaaagaa gggaagggaa agcccagaag agtgtgggga gaggaggcgg ccgtcattct 45180
ggggccctca gtgtgcacaa ccagataaca catgctctgt gggcttttgt accattttgc 45240
ttgagcataa agaaaggaag gctgccccta aatagaaagc actctggagg caaacaaatc 45300
tgactccaat cctggccctg ccactttccc agctgaggac ttagacaagc accctagcct 45360
cttggacatt ctcagagcca tctgctgcaa gtgggtgctg ccatacccac cttactgggc 45420
aggcttgggg gaccaagggt ggtaaatggc tcagtctttc atgatgcggc cacacagcag 45480
gtgcgccatc caggtccatt tctttccttc ctttccccca aatcaagttg tcattaaagt 45540
actagtccac attaatgaaa tcaactgtat taattttcta tttgctgcta taataaatca 45600
tcagaaattt agtggcttaa accaacacaa atgtattacc ttacagttct ggaggccaga 45660
agccctccat aggtgtcact gggctgaaat caaggttttg gcaaggttgc ggtcctttct 45720
ggagggtcca ggggagaatc cattttcttc ctttttccag cttctaaagg tttcatgcat 45780
tccttggctc atgatcttct atagctatag tcagaaaaat tttccatcaa tcatcttcaa 45840
agccagcaat ggcaggatga gtcctcacat caccttgctc tgacaccagt tctctgcctc 45900
cctcttccac atgtcaggac cctcatgatt actttgggct cactctgata atctgggatg 45960
atctctctat tttagagtca gctgactggg aaccttaatt ccatctacaa ccccaattcc 46020
tctttgccat gtacagtgac atattcacag gttctgggga ttaggacgag cctgtctctg 46080
aaaggctact ttacatgaaa attcattttt ttaattaaga tttttttttc ctcttgagac 46140
aaggtctcac tctatggttc aggctggagt gcagtggtat gatcacagct cactgcagcc 46200
tcgacgtctc tgggctcagg tgatcctccc acctcagctt ccctagtagc tggaactaca 46260
ggggtgagcc cccatgccca gctaattttt tttttttttt ttttttgaga cagagtctca 46320
ctcagtcacc caggctggtg tgcagtggtg caatctcagc tcacagcaac ctccgcctcc 46380
tgggttcaag tgattcttgt gcctcagcct cccaaggagc tgggactaca ggtgtgcacc 46440
accacgcccg actaattttt gtatttttag taaagatggg gtttcaccat gttggccagg 46500
ctggtctcaa actcctgatc tcaagtgatc caccaacctc agcctctcaa agtgctggga 46560
ttacaggtgt aagccaacat gcccggcccc agctaatttt taaatatttt ttttgtagag 46620
atggggtttt accattttgt ctaggctggt cttgaactcc tgggctcaag caaacctccc 46680
accttggtct cccaaagtgc tgggattaca gcatgagcca ctgcactcgg ccttaagaga 46740
agatttaata attaatactt tacaacaaga tctggaagag gtgggatgag taactaaatg 46800
aggatacaag taacccgggt catatttgct aatacccttg gtcacattga acttgatatc 46860
ttatcagatt ttcctaatca gctcctttag cagcagtgtt gcagcatctt atctcatttt 46920
gttttttgtt tttttgccta gcacatgcct gtaaatcact ggattgaggt gtttagatgt 46980
ttgttgtcct ttggatgctt cttataaatc catatttcat ggctccctgg aaagtgctat 47040
gcaaatgata agctgcaagg atggaaagga aattgcagtg ctcctgaatt gtaaatgggc 47100
ttttacgagg aggtttctaa ttactcgctc tttctcttga actgaggagt tgaagtgtag 47160
gtggcagatc cataacagat aatcatgtgt gtgatgtgac ttcagcctga gcgtcgagga 47220
ccaagtcaca gagcaggaac agccactctc cagtgtcctt ggggctacgt ctgaggagaa 47280
cctgggattt catatatgac ctgcactggc tggggggctc tcttgacgta acgtgttccc 47340
tctgagcatg ttacagattc tgacattctt atgttccttc tgtggagaga catgtactta 47400
gtgacctaac tcactttagc atatttttgc tcatcgtttg tgtagcttaa aggaatcaga 47460
taattacccc ctccccacta ctttcggaag cacaaatgca atgccctaga attgtactgg 47520
ggactcaaaa agaaaagaga gtagtaaaat ctattaaagg ggacaaagac agcctatata 47580
ctacaagctt tctattttta tggcagagaa tgccattttc taagtaaaca gagaactgca 47640
tttgacctgc aatatcaaat gcatggattt gatgctttgg aaagcaactg ttttctgcgt 47700
taatctgggt gtcttccgtg aaatgtcctc ctgcctttgg cttaaacact agctttgtct 47760
acagccattc catcctgaac ctgcccaatc ttgtctgaat cctggtttca ccactgacaa 47820
gctgtgtgtc cttgggcaag ttacttcacc tgtctgtgct tcagagtcct catctgtgag 47880
ttggggaatc tggacagaat ctaccccata gggcgtagtg aggatgtgtt gaattatccc 47940
aagtggctac acagagtaag cactcaaatg atgtcatcgt tgtcatgatt gctgttacca 48000
gagcctagag ttcattctga tactcgagtc tgtggcccat ccagcccagg taaggaatag 48060
ttggaggagt tgggcatgtt cagcttgaag aggagacgac aggggatatg ggatagttga 48120
atctgtgaag ggccccctgg gatgaagaac tggcatgttc tgtgtggctc cagggcactg 48180
agcaggaccc atttgccaaa gtctcaggga cacagtttct agctatagac agaaaaattt 48240
tctgtcactc agaggatgaa aatagaatga gcccccttaa gaggtaatga gctccctgtc 48300
attggaagga ttccagaaga gctaggtaac cactttaggt gctatcaagg ggcttttttc 48360
tttaaagtcc tttccaaaag cttctgagat tgcataaaca ataggaagcc atcttggtgc 48420
tttaacacaa actctcccca gtgatgaggg ttgagccaaa gccagattgg caagcagaga 48480
ggagacttgt gtacaaggag ttcctcgagt caattgcttt ttccttgttc tagccagcca 48540
gagggctcct gttggaaaac aggagaccgg agaggctgag gcctgaccaa accagcttct 48600
gcaggccagc tgggaggcca caactcctac ctacgggaaa actgaagggc atctctattt 48660
ttagattagc aaaagaaaat aaatttaagt ttgagtctcc tttgcaactt ttaaaagaca 48720
tctttattga gatgatcatt cacattctat aaaattcccc cactttgagt tacaattcag 48780
tggttttagt cttccttgat gattttgatg gtcttttctt aaggctcttg gaagacccag 48840
aagcctctca gacacaggtg ggtgtggagg gcgtagcaca gaggcagact tctcatttcc 48900
tgggtctccc ctttaatgac tctcagagac ccctccttcc ccctgcccct ggcttctacc 48960
ccaggggtgt agagttttgc cattttccaa gcagaacttc atttcctctt ctgtgtctac 49020
actctttgtg cttctttctt gccagctttt tctcctttgc ccgcccttcc ttccttcctt 49080
ccctccctcc ctccttccct ccttccctct ttccctcctt ccccccttcc acccttcccc 49140
ccttcccccc ttccctcctt ccttccttcc ctccttcctt ccttccttcc tgccttcctt 49200
ccttcctgcc ttccttcctt cctgccttcc ttccttcctt ccttccttcc ttccttcctt 49260
cctggtatgt gactaatttc tgtttcagga cataaatgtt gtccaggctg ttctttggtc 49320
tttctgttgg ataatggaca tttggcattg agagaggctg ctttttctga aatcatgttc 49380
ttggggccca gaacctaggt gtgtgcttct gactttgttt tcttcctgat ccaaattctg 49440
atatgtccat ttaaattgat ctagacccac agggcactgt gggacagatc ctcagtggaa 49500
catgactctg taacgagagc attttgtttt gtcaaaatga gaacatatta ttgcctttca 49560
tctgattgta aacataatac atgtttataa aacagtataa tgagacaaaa atgtagacac 49620
taataaggga aaatctccct aattgtattt ctcttcacag agaaagcccc tgttgggcat 49680
atatactcta gtttgtttat ttgtttgact acacatatat gtattctttt cttatgtata 49740
aaaattctga acatgcacat ttctgcaact actgttttca cttgatgatg catggacctc 49800
tctagagtgt acgtttcttc ttccttacaa agcagttggc ttcgcccagg gtacaccagg 49860
acacggtttt ggctctgtcc ccagggtgtc acgggaccag gggatgatct cacagggtct 49920
gccatctgcc ctgcctggcc ggaggctgca tcgagagggc caaggggcac cacgtgtcgt 49980
gggtactgtc aaacaagagc cttcagagcc ttccacagtc tttcttttgc ttcccagcat 50040
tgcttccccg ctggtggact ctgaatctag aactagctcc aggcgcctct ccaaattcag 50100
acgggagctg gggcactatt ataatgcaaa tctaggcaaa gccctcccaa taccaggatc 50160
cagaatgggg tggggccctt tgccctgaaa agctgtttag tttgaaaata caaacaggag 50220
acagaaaagt ttggctaaat taatggataa agttttaacg atggtaacca tagtagggtt 50280
catcgacagc cagcgatggt tctgaacact tgacatgtat taactcacct aatccccaca 50340
ttttacagac aatgcaaagg aggctctggg aggttgagtg acttgcccca aagtcgcaca 50400
gctcctaagt gaaggattcg gagtggactc caggcagcct ggtctgactc cctgcactgc 50460
gctgtgctta tctctggccc caatgccgcc atgcagaagt gtctgggggc actttgtctc 50520
tgtcagacag aattcggaga tgtgtatgct tgccctggta tggcacttct ctttttttga 50580
gacagaatct cactctgtca ccctggctgg agtgcagtgg catgatctca gctcactgca 50640
acctccgcct cccaggttca agcaattctt gtgcctcagc ctcccaagta gctgggatta 50700
tagatgtgca ccatcgtgcc tagctaaatt tttgtacttt tagtaaagat gttgttttgc 50760
tgtgttggcc aagctgatct cgaacttttg gcctcaagtg atctgcctac ctcagcctcc 50820
caaagtgctg ggattacagg catgagccac catgcctggc agtgtggcac ttcttacgtg 50880
tgttcagcgg acactgttta tcttctgtcc ctccaagacg gtgctgagct caggtcgttc 50940
attactggca gacaactgct gatttccaac agaattgcca tcctcttctc ccctgcgact 51000
ttcagagtgt gacctcagac tcaaaaatta gaagtgaaaa catcttaaaa actatcacct 51060
tttcttccta atcctcctct cccctccctg tcttccttgt tgtccccatc taatgaacta 51120
tcatggcaaa aagagcccat ttctggtcat tttctgtggc ctttcaaact cccacctacc 51180
ccactgctcc tgggtgcatt acccgaaagc tgagacttca gtgcagaaag tgccaggccc 51240
tctgtccccc cagatcgcct tccttgtctt ccctgtgctt gcctgtcaca ttgtgtgggt 51300
tccagcgctg gaaggaatga ggaacagatt ctctggttct ccttttgaag tttaccttcg 51360
ctccaccact tctgagacct tcccggaagt tgccccttgt ttctctcctc tccagggctg 51420
ccccagagct gcctctcacc tcttcctgct gtcaccccac caccatcagg gcagaagttg 51480
ggacaaagcc tctcctactg gctcctgctt ttctccctta ggtccagcct cctcttctcc 51540
atcttcagga gtctccttct ccactcacac gtcatgactt cagcacctcg catcagtcca 51600
gaatatgact gcttgttcaa gtgccacctt tctcatgcat ttttttctag tgacaatcac 51660
agccaccctg tggggcagga gtgtcatcat ccccatgttt caaatgaaga attgcagttc 51720
agagagggca agtgactggc ccagcctcaa cagctagcca gtggacccca ccagggcttc 51780
tgactccagt ccgggttccc tttccaccca aatccatgga gggagctgag ccgagaacag 51840
gtgtccttca ggaagacgtg aagccaaagc ctccacctcc aaactcaggg gcccagggag 51900
tccaggcacc catccactca caaggctgga tatggtgcat tccaggagag gggttggggg 51960
cgagtggcct ctctgtgtac ccgtggggat agatgcgcaa gtggcatcgc cacatcgtga 52020
gtcctggctt catgggtgag ctccaggtcc aacgagaagc caagcagggg gcccttcaag 52080
ctcagctttg ggcccgggtc ggggtacagg gtagagcggg cctccccagc ccctgccatg 52140
aggccaaggc agtgcatcgt tcgcagcgta cattcagaaa ccaaagccta ggagctggtt 52200
atcattccgg tttacagctg atggaagagc aggtgcttcc gagaacccac agtgctcttt 52260
ggccagtgac ccaagggtgc ctctgagagg cctcgcagca cccggaggtg ctgctgaggc 52320
aacgccctga ctgtaagaag gaccattcat cctcagagag tggccgtgat gctgctgcga 52380
cagtcccacc atccctcccg actctcactc ccaacagact tcccactgta aagctgaact 52440
ctccagcaaa tcacctctcg ccagactctc tcctcactct ctctgggtcc actagaggtt 52500
cctcagcctc tctttgcctt ggttttccca gctgtaaaat ggagcaaaga gggcctatgt 52560
acccacaaag gtgtggttgg agcgactcct cctacattag ggcctcgagt ggggcttcat 52620
gattggttgg tggaggtctc caaacccacc cagtgccacc gaaggctgag actgcagatg 52680
caatgccaca ggtgtccttc ctcagcctgg gcagctgaac atcatgtgta aaacggggat 52740
aataagataa taacagcccc ttgcacctat gtggctgtga ggattaaaca agataaatgt 52800
gtaacagtgc ctggctatag aaatatttac tcttgttatt aagggaagaa tatgtgtggc 52860
taaaaaggga tcgaagatgt aaaagccaat ccctccccct ctagcatatt taagggtaat 52920
gttgagttgg tttgtggacc atttgctgcc tgttagagct ggaaggtagg gaccccctct 52980
caacagcgat gctacaaatt atacccattg gaggtcaacc aaaagacaaa gcttattggc 53040
tggacatggt ggctcacacc tgtaatccta gcactttggg aggccaaggc aggcggatca 53100
cttgagatca ggagttcgag accagcctgg ccaacatggt gaaaccccat ccctactaaa 53160
aatacaaaaa ttagctgggc gtggtggtgc acacctgtaa tcccagctac tcaggaggct 53220
gaggcaggag aatcactaga acccaggagg tgaaggttgc agtgagccga gatcgcacca 53280
ctgtactcaa accgaggcaa cagagggaga cgcaatctca aaaaaaagaa aaaaagacaa 53340
agcttgttaa taccagcata ttgttaaggg aataaagtag gctgcagaac aactggtgta 53400
atatggtgcc atgtagggaa aattacatgt gtgcatagga gaggggtctg caaggttgtg 53460
ccctaagatg ttagagtggt tcctttgctt ttctctttta taattttgta tttgactttt 53520
aaataaggac cataaatcac ttttataaaa tacattctct ccagccccta ctactccttt 53580
aaagaataag agtggtttgc ccaagaaaga cagttttttt tgctctggtt ttcttgattc 53640
tgacatcaga ggaaactcct tctcatccac ttggggctct gggttcaggg gattcatttc 53700
aggcagatta aagtggtgac caggggcatt cgtggacaca gggagggaca ggagcaccat 53760
cagtttgtct cacacaacca ctgtcatcct cactgaaggc tgttgcctga tcaaaaacag 53820
tattgggcca ggcacggtgg ctcacacctg taataccacc actttgggag gctgaggtga 53880
gtggatcact tgaggtcagg agttcgagat caacctggcc aacatggtga aaccttgtct 53940
ctactaaaag ttcaaaaatt agccaggcgt ggtgggtgcc tgtagtccca gctacttggg 54000
aggctgaggc aggagaattg cttgaacccg agaggtagag gttgcagtga gccgagatgg 54060
caccaccaca ctccagcctg ggcgaccgag ggggactctg tcttaaaaaa aaaaaaaaaa 54120
aaaaaaaata tatatatata tatatgtcaa aaatggggta gtttttagat ctatagtagt 54180
tctaaaaaca aaggccatcc aagcatgaca gatttacaag cactattggc tattccagta 54240
gttacaatgg aggagagaag cttttagtta aaacaaacaa acaacacaac aaacccagaa 54300
accttaggtc aaaaccaaaa ttgtcctctc agacacaatc tgggaatttt ctcatgacag 54360
tgggcattag ccaactgaca tcagcagcaa ccatccgtgt gcacacagtg gcaccacctc 54420
ctcccaaaaa gcagccttca tctatgccct catacaatcg ttgattattc tctttggatt 54480
gaggcccgga attatttaag tttcttcttg ccagcatgag tctttccttt ctgtatgctc 54540
cttatcttct ctctttaatt tggcagttct gcttgaaatc tgggtctttc attagtagta 54600
gttcaatttg gttccagaac attctgtggt gtgatgcaat gtgaccagag ctcacacttc 54660
agagctcttc aagggccagt cttactgagc acctcccagt ggctgcctgt gtgctgggcg 54720
ccacttgtgg tgggcaggag agaggagggg acacaaaagg agacacagct ccttcttaga 54780
agctcaaagt tggggaccag ctgccacaga agagtatgtt tagcatctga gacaccaaga 54840
tccagcgtca caagggtgtt tattaagcct cctcatctct ttctttttct tttttttttt 54900
ttttttcctc aggcagtctt actctgtcac ccaggctgga gtgcagtggc atgatctcgg 54960
ctcactgcat gcaaccacca cctcccgggt ttaagcaatt ctcctgcctc agcctcccca 55020
gtagctggga ttacaggtgc ccaccaccac acccagctaa tttttgtgtt tttagtagag 55080
acagggtttc accatgttgg tcaggctggt ctcgaactcc tgacctcaga tgattcaccc 55140
acctcggcct cccagtgtgc tgggattaca ggtgtgagcc accgcgcctg gccttgctgt 55200
tgattcatct atagtatgtt tgacttgatg acctccagtt accttagaca gaggttctca 55260
tctaagctcc aactttccat ttcctttgtc ctcgtctttc cccttaaccc ctccacattt 55320
ctctcaaaat caccccactt ctaaaaaata ctgtttattt ttcttttaaa tttcaaatta 55380
tctatactca ttgaaataaa tcaaaatagc atggaataag cgaaaaaaat ggatcccacc 55440
cttccccact cccattccct agggctaacc atagttaacc atttaatgac taggtttttt 55500
tgttgttgtt attttttatt tatttatttt gagacagagt cttactctgt cacccaggct 55560
ggagtgcagt ggtgtgatct cggctcactg caacctctgc ctcccaggtt caagcattct 55620
cctgcctctg cctcctgagt agctgggatt acaggtgcct gccaccacac ctggctaatt 55680
tttgtacttt tggtagagac agggtttctc aatgttagcc aggctggtct cgaactcctg 55740
gcctcaagtg atctgcccac cttggccttc caaaatactg ggattaaggt atgagccacc 55800
gcacccagcc ctcctgggct cttttccttt agttgcactc gctccccgct cctggagtag 55860
agggatttcc gagagactgt gggctccagc cttcacctag gcccaggact aggatgcctg 55920
ccctaacatt tatctttata ccttaaagca aaacagctgg accataagca ttcaagaaca 55980
aactgtgaat aaggagaaag ttctcccagg aaacaagagc tttagttatg ttgggccagc 56040
ccttatattc cttagctgtt accagtcact gcttgattta atctcggcta tcacttggcc 56100
tgacaggtct gctgctggtg ccaggatgtc tgggttttga agcctggctc cattacatac 56160
ttcctgtgtg accttgggca acttactcaa cctgtctgtt cctcagtttc cccagctgta 56220
ttatgtcagc ataatagttt gttgtgtgaa ttaaatgagg taataactgg aaatgcttca 56280
aacatggttc ctatcatgag aaatcctgct ttccgcctaa atgtgctgga aaattcctgg 56340
tggtgcagaa caggagacca gagcaaagga aagacagggt gcagaagcca aaaattacct 56400
tggagaacaa agcgcatgtt aaggttattt ttggattcta ggtttatctc tgcttggtct 56460
tcagttacct acaagagatc catttagggg atttttgttt gtttttaacg atagctttat 56520
tgagatataa ttcatatgcc ataaaagtca ctcttttaaa atgtttccgg tatattcaca 56580
aggctgtgca gccttccctg tccttgattc cagtctgagt ttttaactga agggataagg 56640
aggaccacgc tttccccaga ccagaaccgc gggccagggg gcgattccgc tgagtcaccg 56700
cgggcgcctg gtgcgcggcg gcggagcccg ggaccttcct tggctgcccc ctagcgaggg 56760
ccgcagcgca gcctgagaca cccgccgggg ccgctccacg gccgtcggat ttagactgga 56820
agctcggtcc aggtccccag cttgatgcgc ccgcggtgta ggagaccagc ccgactcgag 56880
cttcccctga gcccctggac tcttgactcc agcagggcct gggtaatgaa cgtcagctcc 56940
cctttcccaa aggggttgct ctgttgggaa ggcacccgtt tgatacagta gcatagagat 57000
gggttttagc atcaaaatat cagaattcaa gccttgctct ctgcttacta gctgtgtgac 57060
cctaaaaagg tttctgaacg tctctgagct tcagtttcct catcattcct tctcacgggg 57120
tggttgtgag cattacagag atcctctctg tgaagcccct gtgagtggct catcctgagg 57180
gctgaaataa acatgttatt aataatccaa aactggcaag ggatgttgac tggtccccct 57240
cccttgccca aggagctttc tagaacctga gttatcatta ccaaactgta ctgccttgag 57300
taagaaagtt agaaggaatg ggaaggatgg tggcaggtgg aggaaggcgg attggtcatc 57360
acctccttgc agcaagaaac agccccagat cgtgggaaac ctacagacct gctagacaga 57420
ctaggagcaa aagctggggc tttaagaatc cccagggagg ttctcctgag agagtagcca 57480
gttggatttt gtaagcagag atttgtttgg ggaggaggtg acaacgtagg gagcagaggg 57540
gcaaagctgt cgggaatcct gccttgaggg cagggatgtg tgttgggggg agttgggtca 57600
ctggggctcg gtggccttgg gcaagtttct acctctcagg tcctttaccc acctagggtc 57660
gccatcctgc ccacctcaca ggttacagtg agcctggatg cactgtcatg ggcaggtgcc 57720
caggaaaatg gcagacatgt tccaaacagc acgcagcatt ccccagtgat gcccagggtc 57780
accttggagg tgggcgagat gcctggggtt tctcgtccac cccacaacac ctcaggggac 57840
agccaaagct gtcccttcag gtaagctgca cagaagatgt gaactctgct gcaaagactc 57900
tattctttgg gagcaaaagg gacccagggt ctcacctgca catccctgtc cctgagggcc 57960
taggggttct tggaggcccc agccttggca aaatgaggaa gaaggtgaag gttgtctggg 58020
cccctgccag gctccttcct cggccacgca ctccccttcc tgcacacaca cccttctccc 58080
tccaccccat ctccattgtt gtcagaaaag tcacaataaa aaggtccata ttgtctagtt 58140
cccatacttt taatttttaa aattttattt atttatttat ttatgtattt tttgagacag 58200
agtcttaacc caggctggag ttcagtggca tgatctaggc tcactgcaac ctctccctcc 58260
tgggttcaag tgattctcat gcctcagcct cccgagtagc tgagattaca gatatgtgcc 58320
actatgccca gctaattttt gtatttttag tagagacggg gtttcaccat gttggccagg 58380
ctggtctcga actcctggcc tcaagtgatc tgcctgcctg agcctccgga agtgctggga 58440
tttcaggtgt gagccaccgc actcggctcc acacttttca cttattaaaa gactgtggtg 58500
tccatcaatg gatgaatgaa taaaccaatg tggactatcc ctcccattac ccaaggaatg 58560
aagcacggag ccgtgccaag atctggattc acagtgaaag aagccagtca ccaaaagcca 58620
cgtgctgtgt gacttccctt atacgaaata tccagaagag atacatccat ggtgacagaa 58680
agtagatgag cagctgggga ctggcgaagg ggagaagggg gagcagctgt ctatgaggtc 58740
cagcctttct tctgggtttg gtgagaatgt tttggaacta gatagaggtg atagttgtac 58800
aacattgtga atgtactaaa tgccactgaa tcattcattt taaatcgttc tttacgttgc 58860
atgaatttta agtcaatcaa aaacagttgt ttgaaaagag aaaagcctat gggtagcggc 58920
agcagtgatt ggatttatga ttcgattcca tggctcatcc ctcccctgcc tcaccccctc 58980
gccctccgac gtcttcttct tttactctga actgttatct ttgttctcat ctctctctct 59040
ctctctcaac cctgcagaca cttttccctt tctttgtctg cccccaccct ccagatttcc 59100
gtgtctccag tgtctcccta cgaggcatga attgagactg ggagggtgtg attctgaaga 59160
aggcaccaac agtgactcag ctagcccctt cccccacccc gccccccggg cctcaattta 59220
gctaaaaaac cacagggacg gactcaggag gcaatacctt tccaagggtc cctaaaaaat 59280
gtcccatttt agtgtccagg tttcactcaa ctttagtgcc tcccctaaaa tgtgttcctt 59340
acctcccacc ccactgcatc taagtcactg cctgagaaaa caggattgag gaaaggagaa 59400
aggaagagag agagagagga ggagagagag agagagggag gaaggctgat ggatttagaa 59460
aagaagaaaa caagtggtct gaggaaaaca gccttggtgt gtttattttc ctgtctgtgt 59520
atcgcttctc ggccttttgg ctaagatcaa gtgtattttc ctgtctgtgt gtctcgctta 59580
gattacaggg atctgtgggt gatgacacgt ctggtccagg ctgcgtagtc acctcaaggg 59640
catgcttatt gatgtgtttt tcaattcact atctttgcat gggagtccca ggccaagagg 59700
cacagctgcg ccatttgtct gttggtttag atatccttta tccagttctt ccagagaaat 59760
catcctgccc ttctggagga ggtgggcagc aggggtcaga gatgggaggg aaaggaagga 59820
gccaggtcct tggctaggat gccagggtcc cctgcctctc acctggcctg ggctggaggc 59880
ctcctgctgt cctgtcactg atcactaccc cgccccagcc tcctgagtta gaagacacag 59940
gctaaagtag agtatttctt cattgaaaaa cccatacaaa ataaaggttc ataaaaaata 60000
aaaatttaga ctgggtgctg tggctcacac ctgtgatccc agcactttgg gaggccaagg 60060
caggtggatc gcttgagccc tggggttcat gaccagcctg ggcaacatag tgaaacccca 60120
tctctacaaa aaatacaaaa aattagccag gcatggtggt gcatacctgt ggtcccagct 60180
tctcagccta tggacccaca tagaatacaa tgtcagcata agaagggagc cctggggtca 60240
ccaaatggtt tgggcggcaa agaacctgaa ggttgagaga agtggcttgg ttacccagct 60300
gttggatgtg agacctggcc actgcttctt ccatacccta gacctgcacc ctgacatctc 60360
aagtaaaaag ttgggggatg ttttatggtc caggatgaag gaagggcagt gaggggcagc 60420
ggagcatcac tttgcatttc tgtctgcctc ttactggctg tgtgacctgg ggcaggtaac 60480
ttcccagact cctgggaatc ataacaccta tgatgatgat gatgatgatg atgatgatga 60540
tgatgacacc tacctcaagg attgccctga agggtcacag agatgcctgc aaggcacctg 60600
catggagcaa gcgccccttc tctggcaggt gctgggtgag cactacctgc tgccaggccc 60660
tggggctatg gcactgcgtg accctgcaag tcctacctgg cgaagctgtc gttcttgtgc 60720
tcagtcagtg ttggttgtaa gactgagaag agtcacttca ttttgctctc cagggacatc 60780
tttctgggtc ctattttctg cctatgtcaa gtagcgcctc aaggatgctc ctgaaaatgg 60840
gcttgtcttt cttaacatgg caggtaggtc ccaaagcatt agcatggggc agctgaccta 60900
gcccagccaa tgcagtgcag tgactcttgc aaccgagtct aatcagaagg tccatgaacc 60960
tacgagcatt tcctgtccca ggatcagggt ggaggctgag cctccctgct tagagattct 61020
tcccatgcat tccacttttt tccccaaaag aaaatattga cccttgagag gcacacagtt 61080
tatttatttt gcatagtaaa tagtagcctg tattttaagg atgagttgat ttctgcatca 61140
gcccctgtag gtcatcagcc ttctattggt gcatctgact ctctctagcc ctgcagggat 61200
ggtggagggg gaggggaagg agggatcttt attggaaacc aggacagtga gactcattgc 61260
cctgtcatct gctctgtggt gctgaatgag gcagcccaac agagaaatac cctgagcgag 61320
catccccagc ctccaaaaca gtggcgcatt gccctgagtc ctgggaatga cctttgattc 61380
tcctgctcct gacttggaac ccatggaaac ctctagaagc agctgaggaa aacccaacat 61440
gaaaagcaga actccacact gagaatatag gaggtgatcg gaacatacaa tgattcttgc 61500
taagaccgat tcacagtttt tctttttttt cgatcgaaga aatactggag aagcctaaag 61560
aaggagtcta aaaactctgg cacgtgggcc aaaactgtcc ttgagctaag aatgattttc 61620
acatttttaa gtggttgaaa aatgaaataa aataagatga tgttttgtga cacatgaaag 61680
ctatgggaaa ttcaaattct aatatctata aatagtgttt tatcagaaca cagtcatgct 61740
catttattta tgctcgatgg ctgctttccc gctacaatta cgttgagcag ttacaacaga 61800
gaccacgtgg cccacaaagc cttacaatat ttactatctg gccctttcca gaaaaaaatg 61860
tgccgactct tgaccttaac ctcagcaatt tgggaggccg aggcaggcgg atcgcttgag 61920
ctctggagtt catgaccagc ctgggcaaca tagtaagact ccatctctac aaaaaataca 61980
aaacattagc caggcatggt ggtgcacacc tgtggtccta gccactcggg agactgaggt 62040
gggaggatcg cctgagccca ggaagtcgag gctgcagtga gctgtgatgg caccactgca 62100
cctcagcctg ggcgacagag caagaccttg tctccaaata aataaataat gcaaagtaaa 62160
ataaataaaa ccatataaaa aggaatcaat ttaaaattat aatgaaagct ggccgggcat 62220
ggtggctcac gcctgtaatc ccagcacttt gggaggctga ggtgggtgga tcacgaggcc 62280
aggagatcga gaccatcttg gctaacacgg tgaaaccccg tctctactaa aaatacaaaa 62340
aaaaaattag ccgggcacag tggcgggcgc ctgtagtccc agctactcgg gaggctgagg 62400
caggagaatg tcttgaaccc gggaggtgga gcttgcagtg agccgagatc gtgccacttg 62460
cagtccagcc tgggcgaaag agcgagactc cgtctcaaaa acaaaaacaa aaacaaaaac 62520
aaaaaaaaat tataatgaaa gccaaggggc atagtagaac aaattttcta gagctcatta 62580
agtcaaatga gtcaccagtt agtaaaacgc agtcacgggg aagagagggc aggattcttt 62640
gaagcagcgg ctctcctaaa aacaacccac ccttgtccag ctgccttccc tcctgagggt 62700
gttccctttg actgtgtgac ccccatcccc tatttcccaa ccgtccaagc ccacctctag 62760
cataatacga gcttttaatc cctctccctg accccaaccc gattttgaag cccagtctag 62820
tattttctca aatacacttc ttggctccat tccttccttt ccatcacctc tgccttttca 62880
ctgcatgctt ggaccactgc agtcagctcc ctatgaacag ttgctctcta cccatccaat 62940
cggccccgcc tgctgctgcc aaattcaccg agggcacctc tgtggtgctg cctgtggaca 63000
aagtccaagc cagccacctc acccacctac aggtgagtgg ggagcagcca gcgtgtccag 63060
tggtttaccc catcgccaca gacttggtga tgtgtcgatg tgcagagaag gggtgttggc 63120
agccacaaca caagcaaccc cgccccatgt gagatctaag atgggcgtgc tgggagccac 63180
ctctgagaat ccaacagaag gcagagggga gaacggctca cacggcacaa acactccttc 63240
cttttttttt tttctttttc ctttttgaaa ggagtctcac tctattgccc aggcaggagt 63300
gcagtggtgc aatctcagct cactgcaacc tccgcctcct aggttcaagc gattctccag 63360
cctcagcttc ccaagtagct gggattacag gtacactcca ccatgcccgg ctaatttttg 63420
tgtttttagt agagacgggg tttccctatg ttggccaggc tggtcttgag ctcctgacct 63480
caggtgatct gcctgccttg gcctcccaaa gtgctgggat tacaggtgtg agccatgggg 63540
cctagcctcc ttccatttaa atgtatgcct aatttgccca ttgagaacgg ctgagacgca 63600
ttttaagtgg ccagggtcta cttagagtta gtgctcatga ccaggcccag gtcaagcctg 63660
gctggccaga tggtgccttt gacctgctct gtctctgtgc aaaggaatga gctgaaggat 63720
gggggtgcag tgtgtgggca gtgggctggg gctggcagga ctcagtgact aagggaagag 63780
aactttcctc actaccagcc tgtcttttca gggcaccgcg gggggctttg ggacttggtg 63840
atgaacacag cacagagagc tgtccagcat gcgggtccct ggcttctcac acttcccagg 63900
ctccttcaga ggctctctcc aaagggagct gctctctcta gaacccatga atttggaata 63960
taggcaacca ctgcattggg gaccactgac ctcaaacata gagaccagag caaatggggc 64020
tcatcacgtg aaactcatct ggaactctag caggttcttt tatatatata tatatatata 64080
tatatttttt attattatac tttaagttct agggtacatg tgcacaacat gcaggtttgt 64140
tacatatgta tacatgtgcc atgttggtgt gctgcaccca ttaattcatc atttacatta 64200
ggtatatctc ctaatgctat ccctccccac tccccccacc ccacaacagg ccccagtgtg 64260
tgatgttccc cttcctgtgt ccaagtgttc tcattgttca attcccacct acgagtgaga 64320
acatgctgtg tttggttttt ttgtccttgc gatagtttgc tgagaatgat ggtttccagc 64380
ttcatccatg tccctacaaa ggacatgaac tcatcatttt ttatggctgc atagtattcc 64440
atggtgtata tgtgccacat tttcttaatc cagtctatca ttgttggaca tttgggttgg 64500
ttccaagtct ttgctattgt gaatagtgcc gcaataaaca tacgtgtgca tgtgtcttta 64560
taacagcatg atttatattc ctttggttat atacccagta atgagatggc tgggtcaaat 64620
ggtatttcta gttctagatc cctgaggaat cgccacactg tcttccacaa tggttgaact 64680
agtttacagt cctaccaaca gtgtaaaagt gttcctattt ctccacatcc tctccagcag 64740
ctgttgtttc ctgacttttt aatgatcgcc attctaactg gtgtgagatg ttatctcatg 64800
gtggttttga tttgcatttc tctgatggcc agtgatgatg agcatttttt cacatgtctg 64860
ttggcgaact ctagcagctt cttttcacaa gttcatggag agaggtttcc cactgaggga 64920
atcacatctg tctgatcaaa agaggcttgg gaaatggctc tcctgttcat tccctgaaaa 64980
cctctgatgg aaccactgcc actgtggcag ccccagcact ggcaccccag ccatgattgg 65040
tgccccagcc acatctctgc tgtgagcccc agagccctgg ttaattaatc atccacgtgt 65100
tgatggggag aggcccattc acaaaagcga cataaagccc agggagacgt ggccgtggca 65160
agaagggtgt gggactacat tccgccccca actgagagat tcagaaacca gaaaaaaatg 65220
gaaaaacata ctgtgctctt gggtgggaaa actaaatatc atgaagggag caatttttat 65280
agttttggcc tataatacaa ttccagccga aatcccagtg gaactttgag aatttgcagg 65340
aaaaaaaaaa atgtctaaag tacatctgga agacaaactt acaagaaggt caaataattt 65400
tgaaaaagaa aatgatatct aagcccacct agagaataag acttgagatc caaagctaaa 65460
tcaggaggct ctagcaaaat tgacagataa gcaggacaga gtgcatggtg cattcacctg 65520
gggaagaggg cagattggtc tacaaatagg cctgggtcca ctgactttag ctgttatatt 65580
tggggagaaa cttttcaacc tcactccatc ttaaacctaa aaatattcca gatgaattaa 65640
taaatataaa aaattagacc actaaaaatg tagaagaaaa tggatgatct ttctatacca 65700
tagagcaatg gaataaatca caaaggaaaa cagatttgac tatataaaac ttaaaccctg 65760
cccatcaaaa accatcagaa accaaaataa aaggcaacca actggagaag atagttgcca 65820
caaatatgat caagggttaa tgttattcat aaattaagag cccacacaag tcattagaat 65880
aagcactgag acctgaacag acaagcaaaa agaatgagag tgggtcggcg cggcggctca 65940
tgcctgtaat cccagcactt tggaaggctg aagcaggcgg atcacttgat cccaggagtt 66000
ccaacaccag cctgagcaac atggtgaaac cctgcctcta caaaagtcat aaatattagc 66060
cgggtgtgat ggcacacgcc tgtagtccca gctactcagg aggctgaggt gggtggatca 66120
cttgagcccg ggaggtagag tctgcagtga gccaagatca caccgctgca ctccagctgg 66180
agcaacagag tgagaccctg acttaaaaga aaaaaaaaaa aaaagaggag aaaaatgctg 66240
atctcactag taattaaaac atcaggccag gcgcagtggc tcacaccttt aatcccagca 66300
ctctgggagg ctgaggcagg cagatcactt gagatcagga gttctagacc agcttggcca 66360
acatggtgaa atcccgtctc tacaaaaaat acaaaaattc gccaagcgtg gtggcacatg 66420
cctgtgatcc cagctactcg ggaggctgag acaggagaat tgcttgaaca cgggaggcag 66480
aggttgcagt aagctgagat cgtaccattc cagtccagcc tgggctacag agcgagactc 66540
tgtcccagaa aaaattaaaa catcacatat ttaaacaact ctaggatatc atttaaaaaa 66600
acattaatag actgtttttt agagcacttt taggttcaca gtgaaactga gtggaaggta 66660
cagagacttc ccgtatgttc cctgccctcc acgtacagcc tcccccactg ccaacgtcct 66720
gcaccagagt ggtacacttg ttacaaccaa tgaatcctca ttaacatatc attatcaccc 66780
aagttcatag tttacattag taaaacatca tctttcatct ataagcacaa aaattttttg 66840
gcatttattt aggtgtatga ttaactcagt gttgacaaga ctcacacttc atacccactt 66900
gcactgcatc tgagaagcaa ttggtgtcta cagccgctac accctcaaca agcccgatct 66960
tgtttgaaaa gcaattggtg atgcttctca aaattctatg gacaaagtca gccgggcatg 67020
gtggctcatg cctgtaatcc ctaaactttg ggaggccgag gcaggcagat cacctgaggt 67080
ctggtgaaac cctgtctcta ctaaaaatgc aaaaattacc caggcatggt ggctggggcc 67140
tgtaatccca gctactcggg aggctgaggc aggagaatcg cttgaagcaa ggaggcggag 67200
gtttcagtga gccaagattg caccactgca ctccagcctg ggtgacaaga gtgaaactcc 67260
atctaaaaaa aaaaaattat ggacaaagtt tttcaaaaag atatttaatg caactttatt 67320
tgtaatattg gaacatctga ggccatttca gtgctaacta ttaggggatg gttaggaaaa 67380
tatggtacat atgtggaaag gaacatttgg tagttagtgc ccctgatgtt tacaaaggct 67440
tttagtgacc aacaaatgct catgctataa tcttatgtga aaaaagcaag tagcataatt 67500
gcaactatat ttttaatgca tagaataaaa ggctagaagg aaatatcaca gatccttgac 67560
atacattccc aaacctttgt aaatccgcgg attcatgaaa acagacacat ttgcacaagt 67620
gcctgatctt ttctgttata cattcattag aagtcaagcc ctggtgccac aaagtatctg 67680
ccttttcaaa tgtgatcaga atgttctctt ttgcttcaag gccatttttc acgaagcagt 67740
ggcatttttg cctcttcatc agagtcaccg tgtgccctgg aggactgaga acagcagagc 67800
cgttttagga tgggacaggg cagccaggag gattgggctc actccctact gagtgcctca 67860
ctcccgtaca gcccccatag aggaagaggg gttcaaattt attcctcagc cagatggcat 67920
gtgccgcctg tcctggaatt tcacatcact tatgatggac caaaattcca aaagctgaat 67980
ccatgattgt caaagtctgg tatggcagga tgtcaacagt aatcgtttct gggcagaggg 68040
atgattttct cttcccatct tgctttgtat aaatacattt tctataataa ggttgtatta 68100
cttttctcat caagaaatag caaagtactg ttttactcaa aatatgaata gagccaggca 68160
tggtggcagc ttatgcctgt aatcccaaca ctttgagagg cggatatggg aggatcactt 68220
tagcccagga gtttgagacc agcctgggca acatagtgag acccccgtcc ccactccccc 68280
aaagaaaacc cacaaagcat ttatcctgga ttattcacag gggccaaaaa aaaaaaaaaa 68340
ttcaggcctc ctatagccat gagctacgaa tatgaaaata tgcaaatgtg taagaaaagc 68400
cagcacatcc gatttttact tttactttca cacctctgtc caccatgttc caagagaaga 68460
aacttggtca ttgaaaggaa tagatcaaat ccaaagaaca aaaccactgt gctcattaaa 68520
cttcttagtg ttcacaaagc tttagctgca ggttgaatgg ggcaacccga attggctggc 68580
tcacctgggc tgcagggagc agagatcgcg acactgcact ccagcctggg caacaaagcg 68640
agactctatc tcaaaaaaaa aaaagttcat aaattcaaag ttatgaatta tttttaaaat 68700
aataataatt tacaataaag atgaggacaa agtgtgagta aatggtggtt tctatccagc 68760
tctgttgagc tgaagtggca tctccctgct ggggcttttg gggaagaagg gtgtgtgttg 68820
ctcttcagat cccaagcctc atgcccctac tgggccctgt ggggtgcttc tcagcccacc 68880
aggagagcca ccgttggaac acacacgtgg gggacctggt gggtgccggt gtggtgaatg 68940
ggggccacag cctgactcca ggaagccagc aaactcggag ctggaggagt caggacaccc 69000
ccgatgagtc aagagttggt tttgctgcca gttgacatct gattgaacca tctcttcact 69060
tctccgtgcc tcactttcct taccagacag gctctgctga tgctgtccct ctcctgttca 69120
gtcgtgccct caccgttaaa gagaaagagc aaactgctgg gcagcagcat tgattttttt 69180
aatgaagtgg aaagagagct gggaataaca agtcgggccc acctcacctg cctcacctgg 69240
tgggtttatt tgttttgttt tttttttttt gttttgagac agagtttcac cctgtcaccc 69300
aggctggagt gcagtggtgt aatctcagct cactgcaacc tccacctgcc aggttcaatt 69360
gattctcctg cctcagcctc cccagtagct gggattacag gcacctgcca catgcctggc 69420
taattattgt atttttagta gagatggggt tttaccatgt tggccaggct ggtctcgatc 69480
tcctgacctc aggtgatcca cccacctcgg cctcccaaag tgctgagatc acaggcgtga 69540
gccaccatgc ctggccgtca cctggtggtg ttgaatatga actgctgcgg tgttggtaaa 69600
ttaagcaagc agatagatgt aaataacgct tgggcaggaa tatggagcac gggatgagga 69660
tgggcggcca actgttagag agggtagcag ggaggctgag atctgcctgc catgaactgg 69720
gaggagaggc tcctctctct cttcaccccc actctgcccc ccaacactcc tcagaactta 69780
tcctctcctc ttctttcccc aggtgaactt tgaaccagga tggctgagcc ccgccaggag 69840
ttcgaagtga tggaagatca cgctgggacg tacgggttgg gggacaggaa agatcagggg 69900
ggctacacca tgcaccaaga ccaagagggt gacacggacg ctggcctgaa aggttagtgg 69960
acagccatgc acagcaggcc cagatcactg caagccaagg ggtggcggga acagtttgca 70020
tccagaattg caaagaaatt ttaaatacat tattgtctta gactgtcagt aaagtaaagc 70080
ctcattaatt tgagtgggcc aagataactc aagcagtgag ataatggcca gacacggtgg 70140
ctcacgcctg taatcccagc actttggaag gcccaggcag gaggatccct tgaggccagg 70200
aatttgagac cggcctgggc aacatagcaa gaccccgtct ctaaaataat ttaaaaatta 70260
gccaggtgtt gtggtgcatg tctatagtcc tagctactca ggatgctgag gcagaaggat 70320
cacttgagcc caggagttca aggttgcagt aagctgtgat tataaaactg cactccagcc 70380
tgagcaacag agcaagaccc tgtcaaaaaa aaaagaaaag aaaaaagaaa gaaagaaatt 70440
taccttgagt tacccacatg agtgaatgta gggacagaga ttttagggcc ttaacaatct 70500
ctcaaataca gggtactttt tgaggcatta gccacacctg ttagcttata aatcagtggt 70560
attgattagc atgtaaaata tgtgacttta aacattgctt tttatctctt acttagatca 70620
ggcctgagtg gcctctcttt agcaagagtt ggttagccct gggattctta ctgtagccac 70680
attaataaac aacatcgact tctaaacatt ctataatacc atcttttggc caaattgact 70740
tcgcctcttc ctctctcttt ccaaatgaaa tgtgtttcat ttcactgtca gaccacatgg 70800
ttggggaccc cacagagcac acagccctcc ctctgccttc ccatgctggc ccttcaccca 70860
ctgctggagt gccaggttgg tccaagggtt ggaccaagtt gtctgaggtt gtctcaaggt 70920
tggtcgaggc tgtctccgcg ctgggttgtg ctacaaggag cccttctttc catgggtgtg 70980
gctggcagtg agtgctcaca gcaacagccc acagtgcagc ccgagggcag gatggactca 71040
gtccctgcct ccatacccat ttctaaggag gcaaaatggc aaacactcta cttttctctt 71100
ttaatgctaa aaataagaaa acaccttgca gcccagggta tgggtagtgc atggaagccg 71160
tggagttgtg aggtgggaag tgacctctgc tggatatgtc tattcaggaa gattgctgga 71220
gtgggtgggg tctctgggag gtcccctgag tgtgggaagc tgggaccacc agctttctcg 71280
cacagggagt ggccatccca gcttggagag gttccaggac tggttgggag gcacgtttca 71340
gatttctatc tgttgaatca gcgaagatat tggattatga ggaatttggg aattaggaaa 71400
gtgggtgcag gtgggttggg ggtaggtgaa ggaagacatg ggcgtattgg gggagcaggg 71460
gctgctcaga ggtgttccag aagctctggg tgaggaggtg agagggaccg gggaatgcag 71520
ctcggcccag cctccctgcc tgaggtcagc catcacgtgg tgatggcaag atggaaatgt 71580
gctttctgac tgctccagcc agtgctgcca gattcagctc cccagggagg gcacctgaga 71640
ggctccaagc caggagatct gttttctcct ttgttttgtt tttttttgtt ttgttttgtt 71700
ttattatact ttaagttcta gggtacatgt gcacaacgtg caggtttgtt acatatgtat 71760
acatgtgcca tgttggtgtg ctgcacccat caacttgtca tttacattag gtatatctcc 71820
taatgctatc cctcccccct ccccccaccc cctgttttct cctttgaatc cttcttagag 71880
gccgggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggctgcg gcaggaggat 71940
tgcttgagcc caggagttcc agaccagcct gggcaacata gtgagacctc gtctctacag 72000
ataataattt taaaaattat ccgggcatag tggcatgcac ctatagtccc agctactcaa 72060
gaggcagagg caggaggatc acttgagccc aggaggcgga ggttgccgtg agccaagatc 72120
ccaccactgc actccagcct gggcgacaga gacccccatg tcaaataata ataataataa 72180
ataaatcctt ctcagtccct tcctcactgt gtccccctcc actgaatttt tccacctcct 72240
ctcccacttc ccccactccc gctttccctc tccttctctc cccactccat ctttttcttt 72300
ctctgctgtt tctcgtccct ccctcctctc catcccacaa cactgcctac cctgtccctg 72360
ccccaccctg gtgctcagga tgtgtgaagt gaggggtggt agcccccaag acctcaaccc 72420
cgaaggttag cctgttgaaa ccactttctc ccagctgccc ccctggcagt tggtgctgct 72480
gggggaaact gggattgggg gccagatttt gcctcttttc ctgacaaaga gagatgaaga 72540
gttctctcac caggtgcctg ggactggggt gtgggtgtcc cagcctatcc cagcgcatct 72600
gttctgcatc atgattaata gtgctgcttt cagccgggcg cggtggctca cacctgtaat 72660
cccagcactt tgggaggcta aggtgggcag atcacaaggt caggagttcg agaccagcct 72720
ggccaacatg gtgaaacctc gtctctacta aaaatacaaa aattaaccag gtgtggtggt 72780
gggtgcctgt agtcccagct acttgggagg ctgaggcagg agaatcactt gaatctggga 72840
agcagaggtt gcagtgagcc aagatcgtgc cactgcactc cagcctgggt gacagagcga 72900
gactccgtcc taaaaaaaaa ggagttttgc tctgtcgccc aggctggagt gtagtggcgc 72960
catctcggct caccgcaacc tgcgcctccc gggtgcaagc gattctcctg cctcagcctc 73020
ccaagtagct aggattacag gcgcctacca ccacgcccgg ccagttcttg tatttttaga 73080
agagacgggg tttcaccctg ttggccaggc tcgtctggga ctcctgacct caggtaatcc 73140
gcccacctca gcctcccaaa gtgctgggat tgcaggcatg agccaccgtg cccagtcaac 73200
tccttctcaa aaaaaaaaaa atagtgctgc tttctctttc aagtgtcctg atttgggtga 73260
tagtaaatgc cactctactt ataagggatc tacctcagaa tgctaattgg gacatttttg 73320
tagcactcta ctgttggcag caggtgatgc tcacaacagc ccgtgagggt ggatgacgtc 73380
cgcttcacag atgacaaagg agcctcatgc tcagaccgtg ggctgccaga gcaggtccat 73440
ggctgcagcc ccacatggac catatttccc ccttgtcact ctttccacca agctcccttg 73500
gaacttcagt tattaagctc tcttgggtgg aatccaagtt agaatcacaa catgtgcctc 73560
atatggattg tgccagtgaa aaatgacatt ctatttagag gcagggcagc ctggcttaga 73620
gtcagtttaa aatatgtatt atgctgcaac aaatgtacca tgatcctgta agatgttcac 73680
aacaagggaa ctggatgtgg ggtatactgt ctgtactaac ttcacaagtt ttctgtaaat 73740
ctaaaactgt tccaaaataa caagttcgtt taaaattaac tccaggagac caggtacggt 73800
agctaatgcc tataatccca gcacttcgga aggctgaggc aggtggattg cttgagccca 73860
ggagtttgag acaagcctgg gcaacatggt gaaatcctgt ctctaaaaaa aatcacaaaa 73920
attagccagg tgtggtggcg cattcctgta gtcccagcta cttgcggggc tgaggtggga 73980
gaatcatctg agcccaggag tttgaggctg cagtgagctg tgattgtacc actgcactcc 74040
aacctgggca acagagcaag accctgtctc aaaaaacaaa aatgaaataa agtccaggaa 74100
agaagtaggt tttaccactc ttattttctg aagagaaaac taaatttaat gtgtaaagtg 74160
aggacaagtt caccaagtta gtgtttgagt tgcctaaaat atgtttgcta aaactattca 74220
aagctttcac ataaaacatg atcagaagtt ctatgccaaa acatatgtgt gtgtatatat 74280
atatgcacta tatatactgt atataaaaat gcaaaatcta aattgccaac cttttagaaa 74340
ttgctctgaa aggaaagcat ttcaagataa tttgcttacc caaagaatat actttccaag 74400
aaagcaagta atacttaagg tgttcataat cctcatcaaa ttaattcttg ctactgaaag 74460
cttacaagga gctgttttga tgtcgggtgt gacaggtttg acttggcaga aggtgtcact 74520
ttactaacaa cattttaaat aagtgacaga agacaagaaa ctacacgtta aatgccagaa 74580
caaagagtgt ctaagtggat gctaagagtt gaaatatggc tggatacctg cccaagagag 74640
ctgaaaagta gatgaaagtt ggttacctat aaactagtgc accctaatga attaaaaggt 74700
gttgatgagt taacttgtta tgccttccag ataagacatg caaatggggc ttcttcctcc 74760
ttcactactt ccaagggatt taacaaggag accaatgcaa atgataagga ctgtagggct 74820
caagctgggg acagattggg gaaaggggga ccatcatgcc catatagatg tccctgtgcc 74880
ctggcagtca aggctgctga aaaataacaa aacccagaag tctgcgtgat gctgcctctc 74940
catttgtcca aagccttctt gcggcagttt gcaggctttt gcaaaagctc caggaccaag 75000
gagctatgtt catgctggaa gcttgttcag gattagctgt tctttgtggg atgggtgcag 75060
ccagggccag gtgtccaggg acagtgtttt aacaaagggc atgaggtgtc tgatctcaca 75120
gtggaactcc acttgccttt ttttcatctt ctcattctgc ttcatgcaca gaaccagccc 75180
catcctgaaa ctgactctaa attactcccg ccccaggtgg agtgcctttc tcggagttca 75240
acagagcctt cctgtcgccc aagggacaac tccactgaat gcccaagcca cacccaaaac 75300
ctaacaagta aaaaccaaat tctgtgctcc cccatcctgg gccattcctg gtttctctac 75360
tgctgttggt gataccacca tcagcttgtc catcatgacc ctggccagtt cctcccacaa 75420
ccctccacag cacccaggga cctcacctcc attccatccg acacagatct cctcaccaca 75480
aaccttggtt ttgcaacagc agccatgaga cctttacacc ctccgccctt catcctgtcc 75540
cccactgagg ccccagagcc attccttaaa gcagcgcgcc acaaactata acccacaagc 75600
caattctggt acccagcctg ttttgcacag ccagtgaact gacaatgatc ttttcataca 75660
gccagaaaaa caaaacaaaa caaaaaacaa caaaaaaaaa ccccaccatt ctgagcatgt 75720
gacttccatg ttcaagatgt ctcatgttca gaaaggcccc tggaaaagga ggaaggggag 75780
ctgggcacaa agggagaccc tctcagctga gctcctccca tccagacatt ttcctggact 75840
tcctatccaa tgacttccct tagcttctta tcagccaccc ctgtctgccc aggaggctgg 75900
aagatgtggc cttttaactg ggcacagctc tgtcctctat catatcaggg ctctgttccc 75960
aaggagggta gagagaatgg acaccaggtg gaccctcagc agtctgtgcc acagagggag 76020
tgtttgcaat ttccagacta aaagtcccca tgtgcttgac ggggtatgtg actacaacgt 76080
gatgcttgac ttttcctcat atgaccagag ccactttgtc catctggtac aatgtcagct 76140
atctgctagg ggccctccag gattcccagt caattccata tctgcatcac caccattggc 76200
actaaataaa ataaaatact caagttcctg ctggtgagca tgagcagtgc tacactgggc 76260
ccttcaacca aggtgacatg ataatgactg aaaataatca ctgccactta ttggggacgt 76320
ctcatctgcc aggcatggta caaagtgctt taaataagca ttcaacaatt tcatgctgac 76380
agaagccctg tgagccagtg gagctactac tatgcccatt atacagggga gaaaactgag 76440
gcagagagag gttaggtaat tcgctcagcc tcacacaacc aataggtggt ggagccagga 76500
tttgggcccc atctgcctga ctctctagag gctctatctt ccagtcttcc agagttgagt 76560
ctaagccatg aataggacaa ttagacagca gaggaaaccc attcagccac catgtgcatg 76620
aagagtaagg aatttctgtc atacagaggg gagtgaattc actgagctga gagctgagga 76680
accattgatc tgatggctga gacaccactg ggaagactgg agaggctttt ctgggcatgc 76740
agtgccaggc acaggaggag ctgagggaag atgactaaga ggtactggca aagaattcag 76800
aaattctgat ggaagcttta catgttacca tcacatccat ccatctatcc acccatccat 76860
ccacccatat cttcctccct ccacccaatc atgcatacat ccagtcatct atacaccacc 76920
cacccaccca tccatccatc catccatccc ttcatccatc ccatcatcca tccaattata 76980
catacatcca atcatatatc tgtacataat ccattcttcc ctcggttcat ccatccatcc 77040
attcatccat ccatccaccc atcccttcct tcatccttcc tatcatccat ccaatcatat 77100
atctgtacat aatccattct tccctcggtt catccatcca tccattcatc catccatcca 77160
cccatccctt ccttcatcct tcctatcatc catccaatca tacatatatc caatcataca 77220
tctgcacatc accagctcat ccatctatcc atttatccat ccatccttcc ttccatccat 77280
cattcatcca tcatacatac atctaaccat acatctctac atcattcatt cttccatcga 77340
ttcatccaat tatccatcat tccttcctcc atccatccca ttatccattt gatcatacat 77400
atatcatcta tacatcatcc attcatccat ccatccatcc atccacccat atcttcatcc 77460
aatcaatcat acatacatcg aatcatctac acatcaccca tccatccatc catccattca 77520
tctatccacc catccatcca tccatccatc cattcatcta tccacccatc catccatcca 77580
tccatccatc catccatgta accatccagt catatatcca attacacatc catccagtta 77640
tacattcata catgcatcta atcattcaat tatacataca cacatccata taattctaca 77700
tccaattata cctccatcca attacacatt catacaccca cctaataaat tattaattca 77760
tatatccatc catataatta tacatcaatt atacatccat ctaatcattc agtaattcac 77820
ccaccatcca gtcatctatc caataataca ttcatccaat catccatcca tccatccacc 77880
cattcatcca tccatccgtc cgtccaccca tcatggtatg agccatgatt taccacgatg 77940
gtcccctgtg gacagcccag gtggggcaga actgaaggga agcccagggc tgcccccata 78000
aacatttgcc tcctttacat ggatgagaac tagatccaca tgtataaatc ctcatgattt 78060
gaaggtgctt ttaccaacat tcactcatgg gattctccca ggagctctag gaggaggcag 78120
gtagagttga ggtcatctca cgcattttac agatgaggaa acggaggccc tgagaggcag 78180
gtccaaggcc acctgaccag aaagaagtgg aactgggact tgaacccagc catcttgccc 78240
cttggtccca tgctctctag cctgtaactc ctgcttcctg gtggggcatc tccaggagga 78300
ccctatcggc tggccatggg cctgccctgg agtcttttgc tctgtgtggc catccttcct 78360
ccctcaggag agtgtgtgct cccagagcac aggctgtatc ttctgagcat tttgtccctt 78420
cccagtacct agcactcagc tctgtataca ttgggctctc aagaattctc aaccttccag 78480
agtgtaaggc cttgacctgc tcagccctgg atactgcatg atgcattgat aagcccataa 78540
aataaccagg gcagattgac tcccagtggc caaagtgcca cagggaaggg acaattcagc 78600
ccttctagga ggaggaggag gtagttttct catttctatt aaggcaacaa aagctgcctt 78660
actaaggaca ttcttggtgg agggcgtgac tgtcaaccac tgtgatcatt tgggcctctc 78720
ttgcccaggc ttcccattct gaaaggacag ttttattgta ggtacacatg gctgccattt 78780
caaatgtaac tcacagcttg tccatcagtc cttggaggtc tttctatgaa aggagcttgg 78840
tggcgtccaa acaccaccca atgtccactt agaagtaagc accgtgtctg ccctgagctg 78900
actccttttc caaggaaggg gttggatcgc tgagtgtttt tccaggtgtc tacttgttgt 78960
taattaatag caatgacaaa gcagaaggtt catgcgtagc tcggctttct ggtatttgct 79020
gcccgttgac caatggaaga taaacctttg cctcaggtgg caccactagc tggttaagag 79080
gcactttgtc ctttcaccca ggagcaaacg cacatcacct gtgtcctcat ctgatggccc 79140
tggtgtgggg cacagtcgtg ttggcaggga gggaggtggg gttggtcccc tttgtgggtt 79200
tgttgcgagg ccgtgttcca gctgtttcca cagggagcga ttttcagctc cacaggacac 79260
tgctccccag ttcctcctga gaacaaaagg gggcgctggg gagaggccac cgttctgagg 79320
gctcactgta tgtgttccag aatctcccct gcagaccccc actgaggacg gatctgagga 79380
accgggctct gaaacctctg atgctaagag cactccaaca gcggaaggtg ggcccccctt 79440
cagacgcccc ctccatgcct ccagcctgtg cttagccgtg ctttgagcct ccctcctggc 79500
tgcatctgct gctccccctg gctgagagat gtgctcactc cttcggtgct ttgcaggaca 79560
gcgtggtggg agctgagcct tgcgtcgatg ccttgcttgc tggtgctgag tgtgggcacc 79620
ttcatcccgt gtgtgctctg gaggcagcca cccttggaca gtcccgcgca cagctccaca 79680
aagccccgct ccatacgatt gtcctcccac acccccttca aaagccccct cctctctctt 79740
tcttcagggg ccagtaggtc ccagagcagc catttggctg agggaagggg caggtcagtg 79800
gacatctgat cttggtttag tatccttcat tttgggggct ctgggtgtgg cctgggcctc 79860
tggactttgg ccacggtgtt tgttccagcc cttctcctaa cctgtccttt ccagacactc 79920
ggcatctagg ttattagcac ctcgcatact ttctgacatg ctcctcagtc ctgattttga 79980
ccatcttctc ttgcttccca tctgtgtcag tcaagactgc atttggctgt aagaaacaga 80040
aaccccaact aactgtggca tttacatgaa gaggtttact tttctcacat aatcagatgt 80100
ctagacttgg ccagcacctc aagggtcatt gatgctctcc tgtctttatt ttctgtcatc 80160
tttagtggtt ggattgttgc ctcatggtta caaagtggct gctgcacttc caggcatcac 80220
atctgccttt gaagcaggaa caagttgcaa agtaaagtgg ccaaaagggc cctgaaacta 80280
aatgtgtccc cttaggaaag caggagtttt cttgcaagtg gcaatcttct gcttatgtct 80340
cattggccag agctgggtct tacggccacc ccttgctgcg agcaaggctg ggacattgag 80400
cattttgccg tccaacctct ttagcagaat aaaccaaggg ggaagaacgt taatagtggc 80460
ttttgagtca ctagttggca gtatctgccc ctctatcttt ccatcctccc catggagttt 80520
caaggttcct ttctcagtac ttcttcaggc tctgcacgtt catttggatc ttgtgtcttg 80580
gggtgaaaaa ctggcccaag tgtctcccca agcatccacc tttggattaa tttggaaaat 80640
ggctgtcaag tgcccgcctc ttgcttggta taatgctaca gctttagagg acgcagcagg 80700
catgggcctt gccgctgagg ttcttagcct catgagaata tccagatcag attctcttgg 80760
ctccttctta gagccagtga tgcaagacac ttcctgctca tcttgtcggg acggttttac 80820
aagttgcctg ccatcctgag aaagtctaca aaacgatgcc agacctcatg ccagcttccc 80880
aagccttgac tctcagtgct ccctcaacag gattctggaa gaatctccca aacaagtcgc 80940
aatcccctct ggaccctgtg caggcatgag actcaagagc attggctccc acccctggtg 81000
gagggaacac tgctggggct gggatcttgc ctggttgctc cgcctgcacc caagacaacc 81060
ataattaaaa tgtccttcat tgaacttgga aagccttcaa agctgacaac tccttatgtg 81120
tacccggaaa ggcctgggag tgtgccaggg cattgctcgg gagggacgct gatttggaag 81180
catttacctg atgagagact gacagcagct cctggtagcc gagctttccc tcctgcctct 81240
gctgtgaagg tggacccatc caacagtcaa atgcctgact ctggacagga gcggacctat 81300
ttattgccat gcaagggact ctgcactttt gaattgtggg tcatgggctt ggatttaggg 81360
gttagagctg ggagaagtct tggaagtcac ctagagatga cactgccatt ttgcagatga 81420
ggaaaccgtc caatcaaaat ggaccaagga cttgcccaaa gcctcacagc aaaaccatag 81480
gcccccgcac taaccccaga gtccctgtgc tgtcttaaga atcaaatagt tgtaagcaat 81540
catctggttt tcagtatttc ttcttttaaa atgcctgggg ccatgcccag cagtctgttt 81600
cactgcagcg tttacacagg gctgccgggc tttcctggtg gatgagctgg gcggttcatg 81660
agccagaacc actcagcagc atgtcagtgt gcttcctggg gagctggtag caggggctcc 81720
gggccctact tcagggctgc tttctggcat atggctgatc ccctcctcac tcctcctccc 81780
tgcattgctc ctgcgcaaga agcaaaggtg aggggctggg tatggctcgt cctggcccct 81840
ctaaggtgga tctcggtggt ttctagatgt gacagcaccc ttagtggatg agggagctcc 81900
cggcaagcag gctgccgcgc agccccacac ggagatccca gaaggaacca caggtgaggg 81960
taagccccag agacccccag gcagtcaagg ccctgctggg tgccccagct gacctgtgac 82020
agaagtgagg gagctttgcg tgtttatcct cctgtggggc aggaacatgg gtggattctg 82080
gctcctggga atcttgggtt gtgagtagct cgatgccttg gtgctcagtt acctccctgg 82140
ctgcctgcca gcctctcaga gcatttaggg ccttctggac ttctagatgc tcctcatctt 82200
gcctcagtca gcgcgtcagt tccagagact tctctgcagg gttttctggg gcaggtggtg 82260
gcagacccgt gccttcttga cacctgaggt cagtccaccc tcctgctcag actgcccagc 82320
acagggtcac ctcccaaggg gtggacccca agatcacctg agcgcacaga gggtgcagat 82380
gactggacca caccttttgg tgatcttaat gaggtggtcc cagaggagct cagacatgca 82440
atctagcatc cagttctggg actctgtctc cttttcaaac gtattcatgt agaacaggca 82500
tgacgagaat gccttgtcaa catgggtgat ggggaatcaa tcagacaggg cgccgggctc 82560
aaggctgcag tcacccaaga gtggctcagc ccaccaggcc ctaggaaacg cctgcacagc 82620
ctggagctcc tggagtcatt tccttcatgt cttcttcact gcacttacgt aaagatgcca 82680
gccattggtt tggtgatttg gagggtgccc agttgcccaa caagaaatgc agaagaggcc 82740
tagccaggat ttcaccagca gtggagagta gagaagatgt ggccagaaaa gagtttcctt 82800
tccctcctaa agatggtact ccctgcagct actggggaag cctgcagcat tctctagggc 82860
tctgtgtgtt gagagcagcc ccaccctggc cccttctgag tgcatttctg ctttgtgact 82920
tgatccgtga agtcccctga gatgggcaga ggggatgtcc tcgaagctgg ggcagagcct 82980
catccttgaa cgtgaaggac gtttgaagac tgtggcatga tcacaggatg agatcacagg 83040
gaacttgagt ttctctcctc ctctcccttc acagttattt cactgaggga aatccctccc 83100
ctgcccagaa tgaaaactct agccaactct tgacttttcc atcactccaa agtagttgaa 83160
agtacattag tctccacagt ggcaaaacag tgtgcaaaag ctaaataatt agaacagcca 83220
gtcccatgtg acagtcaaag cttctaactc cattcaaagt tgcagccatt cccctcgagg 83280
gctggcaggg aggggagggg taagagaaac aggaaggttc ttactgagtt ggtcctggtg 83340
tgagctgcgt cacactccct gcagaggttt caaggagact ctctctctct ctgtctccat 83400
ggggacctta tttgaattct tctactctta ccccagcctg ccatctccag ctatcctccc 83460
ctgaagagcc cttctgctgc gctggattct ggtggccatg tcatctcctc ggccccgtgg 83520
gagtctgaag atctggctgc agcctcacct ctgaggtcct gctagttgcc acctcttaaa 83580
catgatctga ggctcccatg cactctgacc tgtgcccaca tggggcccac gggaaacacg 83640
ctggcaagca aactgtgggt gtgcagacgg ttctcagggc tgcagcacct gtcctttgct 83700
ctgcccccaa agcaaggcca gcccatcttc catcctctag tgttccttgg tggggccctg 83760
accacagtcc accaggtccc taaccagagg ggacacacac caggtgtcct caatgtattg 83820
ccttgaaaca gttgtgctgg gactgtgatg gggggtggcc atgtagccac ccccaccacc 83880
cccaagccac tctctccaag gaaatcctcc taaagatccc tttacatcct ccatgtggtg 83940
gggaggttct agagttgggt gcatgtgtct tcagctactg acaatgcaga ccttagttgg 84000
cacctcgctc tggcctatcc tgtttgctgt tcttggcgct ccagtgaaac tccccatggg 84060
ccatccagtt ggggtgcagt gtggccaccc ccttgcaggt tcctgccttg ctggagagca 84120
cagggccctc ctggctcttg taaaacactc cccatggtac agagaggcca gcagtgatgt 84180
gaggcccaac ctccctccat ggtgttccca agcagctccc tttctggggt caaggggtgg 84240
caaagacagt gcagcgtcca atttctgact caagccgggc ctggctatcg cagctctgca 84300
ctgtgtgtga cagcaaggca actcacccag tgccgtggca gtgaccgtgt ccgaggaagc 84360
ctcctcacac cctctgtctc aaggactctg gcatttagct ggacttgctg tagctctgag 84420
cctttctgcc attgccatca ccttgtcaga aactcaggcc gaatctgcac tcagagttgt 84480
gcccaggcag ttgagccaac acttgctcag cgatattgtc acatgacaag gcactgtcac 84540
cactgggcgt cgtgggtagc gcagtgtcgg ctggatggac ccggagggtg tctgtgtcat 84600
gctagtgcta gtgatgggag ccccgtgagc ccattgcccg ccctcccatg ccctcagcag 84660
ctgcctgggg acagccaatg gcctgggtgt ttctgaggct accacatggc ttccaggaaa 84720
ctcgagaacc tttctctccc ttgcctacac tcttcacaca ggcctgtgct ggccagcggt 84780
ggggatccgg cattcctatc ttaggtgcag aaagtgactg actcattgca ggcctgggag 84840
ataagactga tggcccagcc agcaagatgt atggatttct cagaggcagt ggcctctgtc 84900
attgtcctca ggaaatgctg gtgattctgg tggcctgagg tcaatgcatg tcaacgtggc 84960
caacttgcct tataaacttt ttttctggac aattgcgtgc actgtcctgt aacagtgtcc 85020
tgttgtttat gatgcagaaa taggtgtttt taaagcctat tgattttggt actattaatg 85080
tggtcaggaa ctttctcagt ctttcttgtt tggggtgagc tgtggcttcc taaacaggaa 85140
cccaagacac ccccaaaagc tgctcaccag cactgccagc ctccctctta ccaagtagca 85200
cccgttcagg acattctgcg aaaggcattt gcccagaagt tgggaggaag gaaatgtaac 85260
attttggggc acctaccata tgccaggcac caggctaaac gtgttcacac aaattctctt 85320
actaaccctc accatccttc tacaagacaa actagtatct tcatcttggg gttcaagatg 85380
aggaaatgga ggctcagaga ggttgaatga atgccggtgc ctggatatga accccatctg 85440
cctgactccg caacccaggc aaagtctttc cttgaacttc ccagcagcca ctgcttagac 85500
acagcctcca caaccatggc tcagcagcaa attgcttctc tgacctcact cagcctgtgt 85560
gtccttgttg agtgaggcat tcaggaccct ggtcccaaag tggagaaagt ctttcctact 85620
aggtcatagc tacacctgca tgtgggtgct gtgccttttg tttagtgaac ttttatcacc 85680
agcatcctca gcaatgacat ttgcagagaa gccagagctg aggcaccttg gtattcttgg 85740
gatgtgactt tcctgaatgt ttaagggaaa atgcccgaag gtacagagag cttggtttct 85800
agtaaacaat aactgtcttg cttttacccc ccttcatttg ctgacacata caccagctga 85860
agaagcaggc attggagaca cccccagcct ggaagacgaa gctgctggtc acgtgaccca 85920
aggtcagtga actggaattg cctgccatga cttgggggtt ggggggaggg acatggggtg 85980
ggctctgccc tgaaaagatc atttggacct gagctctaat tcacaagtcc aggagatttt 86040
agggagttgg ttcttatcaa aggttggcta ctcagatata gaaagagccc tagtggtttt 86100
tttctaatac catttctggg taattcctaa ggcatttagt gttctgaaag atgctagcct 86160
tgtccagcct gggagttgag aatgaatgtc taacagaaac tctaggccgg gcgtggtggc 86220
tcacgcctct aatcccagca ctatgggaga cccaggtggg cagatcacct gaggtcagga 86280
gtttgagacc agcctggcca acatgtgaaa tcctgtctca ctacaaataa aaaaattagc 86340
cgggtgtggt ggtaggtgcc tataatccca gctactcagg aggctgaggc aggacaatcg 86400
ctcgaaccca ggaggtggac gttgcagtga gccgagatcg catcattgca ctccagcctg 86460
ggcaacaaaa gcaaaactcc gtctcaaaaa aaaaaaagaa actcaaatat gtgtgacagg 86520
cgattctcac tgcaggctgc cctgtggctg atccaggagc aaggccttaa ccatgtcatc 86580
cccaagcgat tgcttgtaaa ctttcttctg tgcagccttc aacccttatt atgattttct 86640
tctcaggaac caaactgctg tattcaagaa aggcagcttt gtgtaatcat ttatcataaa 86700
tatcttaaga aaaatcctag agattcctaa ttttaggaaa tgggagacct atggtactga 86760
tataatgtgg gctgggcttg ttttctgtca tttgctagat aaatgaactt gagagcctac 86820
tgtaaaatgt ggaagcttct agattgcaga agggctggaa agacactgtt cttttctccc 86880
gagtgatggg atctgtccag tatttagagc tgcctctgag gccatctgat tctaggagac 86940
tctgcctcgt tgaggatatt ttgaggccta actacacatt cctgccccca gagaggtcac 87000
agcctatagc aggctgatgt ttctcatgtc acatggcaca gaaaggcaca ttttcgttct 87060
caggctaaca aagagcttca aaaactatta gaagggacag tggctataag agaagaacct 87120
cagtcaatgt gtgaaattaa ctaggaacct ggctcctgtt tcttttaggt catgtttttc 87180
agcttaggta aaactagagg ctttgataaa gcatgacctc tagaaatcat tgcttttcat 87240
aaatggaagt gggtttgagt tttttctact gattgttagt gcaggtgatg tctacatgcc 87300
cccagaacat attccatgca acaaaaaaag cccaggtcac cgtctttgct gggaacttga 87360
cttttgtgct cactgaattt taagctttct gacagcagcc tggaatcatg gagggataaa 87420
gtacctatta gtaagatgga aaaaggtgtt tcaggttgga gctgcagtct gttgagagta 87480
agctatggga aggcctgtat acgaggggtg gacttttctt ctgtaagtgt ccagagacca 87540
ggcctcctga agagggcatg ggggcttaac ttacctggac tactgtgttt acaatactca 87600
tttatcttga actcctccta acccctgaga attgctacat ttagtatttg ctgagtactt 87660
cctagcatcc tagggaatca atagaacatt ctcccaacca ggctgggtgc ggtggctcat 87720
gtctgtaatc ccagcacttt gggaggccaa ggtaggcaga tcccttgagg ccaggagtgc 87780
aagactagcc tggctgacat ggtgaaaccc cgtctttact aaaaatacaa aagttagcca 87840
ggcatggtgg tacacacctg taatcccagc tacatgggag gagtaggagg caggagaatt 87900
gcttgaacct gggaggtgga ggttgctgtg agccgagatc atgccactgc actccagcct 87960
gggcgacaga gtgagtgaga ctctgtttaa aaaaaaaaaa aaaaaagaac attctcctaa 88020
cctggcttct tcctccaggg gtgtaattaa tcatgtcagt ttcctcattg atacacacac 88080
acacacacta caatcctgta tccattactt ttcaaggtac atttactatt tacgtttggg 88140
gtccttgtct cttttttaat agtgtttctt aaagtcttgt attatatcag agtacagtaa 88200
catcccagtc aagagcactc tagtaagctc taggaggaaa gcgacttccg gaaggcagtg 88260
gagacctgtc ctgttggggc agcatagggg cagcccctgc ctctggtcag ttctggcgct 88320
caggctcagg gttgcctctg ggctgttctt cccagagact gacaaagggc tcccataagg 88380
cacctgcaga gcctgtgaga agctgaagtc aatgttttcc tgacaccagt tgatctgtgc 88440
aggatccatt gatttaacca cctgctgtgt ggcatgcact gtggtcgatg ccaggaacag 88500
gaattggagg ggcccatgag catggccagt atcacaggct ggaggtgctg ctgcgctctg 88560
accgggcctc ttggggatga gcccatgtca accaccttgc ctccgatggg gtcgggccca 88620
caggttacct ttgtgtgtcc atgaccacac cttcctcccc gacctcatcc aaatctcttt 88680
cttttccaag cccctgaatc cttcagggct gcaggttttg tttaaagcag agctggtgag 88740
ttgcataggt tgttgcgttg ggactagatg gggtgttcaa agagttggga gttaaaaaac 88800
ataaagggta tttattagga gaaccaagga gtgtaattct cctgttctta atatgcggcc 88860
aggttaatga atgtcacgtg aatgaaccag aaaaaaatga agtgtgccct tgatcagctg 88920
ggttggtgtg cagcaagctg tgtgaccagg ggacagcagt ggtcctgagg gccgtcactg 88980
tctgccgtgc agagcccttc ctcccacggg ggcctacctc acctgtgcca agggcttgtc 89040
tgtggtcagt gacctggata gatctgaatg gggcttcttt ttcgaggagt cttatggcag 89100
gtctctcagt aaagactcca ttcttgatga tcacacattt tggattttcc aaatctgtca 89160
gagaatgggc ttgaggcggg gtttgtgggc actagtttca ctggtttcat ttaccaaaaa 89220
ggggagcaga agtcaagtat ggtggctcat ccctgtaatc ccagaggcaa gagaattgct 89280
tgagcccagg agttcgagac cagcctgagc aacataagga gaccccgtct ccacaaaaat 89340
gaaaaataac attttagtca gacgtggtgg catgcatctg tggtcccagc tgcttgggag 89400
ggtgagatgg gagggttgtt tgagccctgg agttaaagtt gcaatgagct gtgattgcac 89460
cactgcactc tagcctgggt gacagaacga gaccctgtct caaaaaaaaa aaaaaagaaa 89520
gaaaaaaagg aaaaaaaaaa ctcatgcctg taatcccagc actttgggga ccggggtggg 89580
cagatcacga ggtcaggaga tcaagactat cctagccaac atggtgaaac cccgtttcta 89640
ctaaaaatac aaaaattagc caggtgtggt ggcacgtgcc tgtaatccca gttactcggg 89700
aggctgaggc aggagaatcg cttgaaccag ggagtcagag gttgcagtga gctgagatcg 89760
tgccactgta ctccagcctg ggcgacagag tgagactctg tctcaaacca aaaaaaaggg 89820
gtggggggcg ggggcaggag aacagtgaga ggtagggaga ggaaagggga ttctcgctac 89880
acccaaacca gataccatct agaggctaga atctttggga ggctcaaatt ccctagaaag 89940
caggagaagc ttctgtagcc ctcccgcttt cccagtagat taagcccagg gcggctccag 90000
atgtgtgaca tgctctgtgc ccaaccagag cccatcatag gcagaggaat aacacccaca 90060
ccagaagggc cctcggaggt caccacgtcc aagaaccctc tttacagatg aggaaactga 90120
ggcccagaga ggggagagcc acctagcgag ctggtggcgg ctagaccagg agagctgtca 90180
ttccaagcaa gcaaaggcaa cgagacgagc ccagagctgt gctcccatct ctttgttagg 90240
gggcctggga tgccctctca gtgtcatttt gtccaggatg atgctccctc tcttaagcga 90300
ttaatgcgcc cttgctaacc ttttgctatc gctgcctctt caaaccagag gagttgagag 90360
ttccgggccg gcagaggaag gcgcctgaaa ggcccctggc caatgagatt agcgcccacg 90420
tccagcctgg accctgcgga gaggcctctg gggtctctgg gccgtgcctc ggggagaaag 90480
agccagaagc tcccgtcccg ctgaccgcga gccttcctca gcaccgtccc gtttgcccag 90540
cgcctcctcc aacaggaggc cctcaggagc cctccctgga gtggggacaa aaaggcgggg 90600
actgggccga gaagggtccg gcctttccga agcccgccac cactgcgtat ctccacacag 90660
agcctgaaag tggtaaggtg gtccaggaag gcttcctccg agagccaggc cccccaggtc 90720
tgagccacca gctcatgtcc ggcatgcctg gggctcccct cctgcctgag ggccccagag 90780
aggccacacg ccaaccttcg gggacaggac ctgaggacac agagggcggc cgccacgccc 90840
ctgagctgct caagcaccag cttctaggag acctgcacca ggaggggccg ccgctgaagg 90900
gggcaggggg caaagagagg ccggggagca aggaggaggt ggatgaagac cgcgacgtcg 90960
atgagtcctc cccccaagac tcccctccct ccaaggcctc cccagcccaa gatgggcggc 91020
ctccccagac agccgccaga gaagccacca gcatcccagg cttcccagcg gagggtgcca 91080
tccccctccc tgtggatttc ctctccaaag tttccacaga gatcccagcc tcagagcccg 91140
acgggcccag tgtagggcgg gccaaagggc aggatgcccc cctggagttc acgtttcacg 91200
tggaaatcac acccaacgtg cagaaggagc aggcgcactc ggaggagcat ttgggaaggg 91260
ctgcatttcc aggggcccct ggagaggggc cagaggcccg gggcccctct ttgggagagg 91320
acacaaaaga ggctgacctt ccagagccct ctgaaaagca gcctgctgct gctccgcggg 91380
ggaagcccgt cagccgggtc cctcaactca aaggtctgtg tcttgagctt cttcgctcct 91440
tccctgggga cctcccaggc ctcccaggct gcgggcactg ccactgagct tccaggcctc 91500
ccgactcctg ctgcttctga cgttcctagg acgccactaa atcgacacct gggtgcagct 91560
gctccactcc ctcggcctcc tcccgtgctc aggctgtggc cgcacgcgcc cctcacgctt 91620
gcccgccact ctgcatgtca ccagcacccc cgctccgtgc tccccacctt gtttgactct 91680
ctggccactt gatttgtcca caacggccca tcagcccaca ggaggtttgg tgggtgcctt 91740
ccaccgacag gatgacgggt gccctcatgg tgtctagaac tctccaaccc tcccatgtag 91800
gcataagcag ccccactttg cagatgagga aacggaggct cagagaagta cagtaacttg 91860
ccgaaggcca atgagtagta agtgacagag ccaggtttgg gatccaggta ggttgtctct 91920
gaaagacacg cctgtcctgc atcccacaac gcctcccagg aggtgctgga gtgtggacgc 91980
ctaacacaga gatgtgcagg gcacacacag caggtgacac acacagcatc cagaggtggc 92040
ccagagctca tgctgtgcct ttggcccagt gccctgcccc cacccactct gccttgtggc 92100
aggaagacaa ggagcagaca caagatctcc ctggtccaca tgccaccacc tccctctgca 92160
gaggacaagg ggatcctcat gctggcattg gagggggttg agcagggccc accttgagcc 92220
ctcaggagca cgaccacagc agccctgcag ggagggattg gtgggaggag agtcccaagt 92280
atcagggaga ggagagttgg tgtcccacag gagacctcag agccacaagg cgagcttgtt 92340
cataaatttg ggacccttag catttcacag ttatttgcag agcccagaaa tggatgttac 92400
tgaagctcac agttgcaagc atctgttaaa tttttattag attttacttt tagggaaaac 92460
tttgaaatgc tataaagaag cctgtgttta aaagttaaga cagaggctgg gggcgatggc 92520
tcacgcctgt aatctcagca ctttgggagg ccaaggcagg tggatcattt gaggttagga 92580
gttcgagacc agcctggcca acatggtgag accctgtctc tactaaaatt acaaaaaatt 92640
agctgggcgt ggtggcgggc acctgtagtc ccagctactg gggaggctga agcaggataa 92700
gtgcttgaac ccaggaggcg gaggttacag tgagccaaga tcacaccact gtaccctaag 92760
cctgggcgac agagtgagac tctgtctcaa aaaataaaat aaaataaagt taagagagaa 92820
aaaaatatat cctatatcct ttgttaaatt ccaaaacagt aggggacaaa taactgactt 92880
gacaggttac tacaatattt cctgaaatga tgttttcttg aatactggcc tactagaggt 92940
tcataggtgt gtttggatta aaaaagagtt ccatggccca gtgactgggg gaaaaaaata 93000
aaagactaaa gtaagttaaa caggcttttc tgctgcagga cttgtcagag cctttaatgt 93060
actaatggcc attgtgaccc tctgagaagg tcacagagtg ggtttcccaa acttacttga 93120
ttctacctgc taacatttcc tggaggaagt ttgggaaatg ccgatttagc agattctttt 93180
gttgtgccgt ggatggtgct ggttgatgtg ggcaaaacaa agaacacgtg agtcagatcc 93240
gcctggggct cttactaaag tgcaggttcc caggtgccac tttaggctta cagacccagt 93300
tgtggggtaa gcctgggagt cttttagcag gtgattctgc cacatagtat agttggaaaa 93360
cctctgggca tactcattgc tggtccctct agaaatccag gtgacaatag ccaatgagaa 93420
gctccaagag acccagttgt ccatggggta gagggaatgt gatattgaaa ccaaagaaga 93480
aaatctatga tcagttttca gcagtgactg tcaagagaag gagaagggtg agttagcgct 93540
gatgctggct gacaggtcag cgggttggtt tcaccaagga gtgtgatgaa ggctgatgtt 93600
gtctgtggga atgtatgatg gtaactggtt tgtagctaat ttggggaagc agtgagaatt 93660
cgtgcccttt gaagaccagt aagtggcaag aaacccacca ggcctggctc agggctgggc 93720
tgggcttggc tcgtctcaga gcagctgggg ctggtggcca aagccaccat tagtgagggg 93780
caggccctgg gggtacaacc agcaactagg ggacaaagac aaccctgcca gcctctccta 93840
ttctggaggc gtgtgaccag aaatggagat gggttggtca gcataagatg gccaggaagg 93900
tggaaatcag gactgctggc aatctagcca catgggcagg ggagccgggt ggttccaggc 93960
agtttccaag gccaagaggg tgagcaggca cctcacaggg aatcagggcc aagcctggct 94020
gcagtgtgga gacaatgcac ccacccccat ccttggatct tgcaggaggc tgggtcctca 94080
ctgagctacc aacatccatg gccctgaggc ttttaaaaca cccatccatg gagtggggct 94140
ggtcccagtg gggtgaggct gaccctggca gaaacagggc aggagcctgt gggttaggga 94200
gactgcacct tccttagata gcctccatgc catcatgtcc ccgtgacagt ttctgctgcg 94260
tcccctctgc atggtcccac cctcggccag cctgctgccc cctcttgcca ggttgcgcta 94320
atcagtgacc ccagtgtgct gtgttgatac taacaatgcg aggcctagca gattcaaggg 94380
aaaagagaac caactgggtt tccaccagac ccaactaaac aaacatggac ctatcccaga 94440
gaaatccagc ttcaccacag ctggctttct gtgaacagtg aaaatggagt gtgacaagca 94500
ttcttatttt atattttatc agctcgcatg gtcagtaaaa gcaaagacgg gactggaagc 94560
gatgacaaaa aagccaaggt aagctgacga tgccacggag ctctgcagct ggtcaagttt 94620
acagagaagc tgtgctttat gtctgattca ttctcatata taatgtgggg agtatttgtc 94680
actaaagtac agctgtcatt taaagtgctt tgtattttgg ggcaggcttt taaaaagtcc 94740
agcatttatt agttttgata cttaccccag ggaagagcag ttggcaggtt catgaagtca 94800
tgctcctaat tccagctttc ttagtgtact ttcagtgaga ccctgacagt aaatgaaggt 94860
gtgtttgaaa accaaaccca ggacagtaaa tgaaggtgtg tttgaaaacc agccctagga 94920
cagtaaatga agccatcttc tcactgcata aactgcaccc agatctttgc ccatccttct 94980
cagtatttca cttcacccat tgtttactgt ctcaatgact ggggaaatgt ctggggaaat 95040
gctcccgtaa ttgcacagtg gcgtttttcc tggaaaatcc caccatggct ctagataaga 95100
cctatttttc ttaaaggtat ctaaaatttc cagcataaat tctgtctgaa acacctgaat 95160
tttaatcagt actggagccc ggagggcatc tccagttgcc acatagctct gagcattcag 95220
tggtgtgttg agggctgctc ccggaagtgc ctgcagagtc agggctcccc agcctcatct 95280
agtgaggcag tggaagggcc tgtggggatt tggagagctg gcctgggtct ctgaagtgat 95340
agtgacagct gcttgtcaat cacggtgcac atttagtgcc gggggcaggg ggcagggaat 95400
accagcctca tgcatgcatg cattcatttg ttccttcctt cattcattca ttcagtacac 95460
atgggtacaa catccctgcc ctggagttgc ccagagtcta gggaggggaa agatctatta 95520
ccctgggcct cggccagctg gggagtgctg ctggtggaga ggggccgtgt gcagcgaggg 95580
aaggaggagt cgtcaatacc cccaccccag ctttgctttc ttgtcatcag ccccagggcc 95640
ccagcctgtg tccctcctct cccattgcta cttcatctcc tgggtcctcc ttaccaagcc 95700
tgaccacaca gagggccttg gccgcttcca tggggaattg gaaagcaata agatagcatc 95760
ccctagaagc ccagtgaagt ctgggacagg acccttctct gagctctgac ttgctcttgg 95820
aaacacttcg aggcttagcc tccccacttt gtttcccaag agtgtgacct gttcccctcc 95880
aaacaccccc ttctcctcca gggccatgcc cacccgtcaa aatcccccac gggcaggacg 95940
aactgtgggt gtcagtcacc atctatcctg catcctggtt ccagggcccc ccccagcccc 96000
gcctccatag ggacaggcgt gcagacaccc gtccctggct gcttcctctt gtggaatggg 96060
ttcaaaagta agcagtgttg tttacactga caaactgaaa aaaaaagaaa aagagataac 96120
attggaggct tggcacagtg gctcatgcct gtaatcccag cactttggga ggctaaggtg 96180
ggaggatgtc cccagcccaa gagttctaga ccagcctggg caacatagca agaccccatc 96240
tcaaaaaaaa aatttaattg gccaggcaga ggtgggagga tcacttgaac ccaaagggtg 96300
gaggctgcag tgagccgtga tggcaccact gcactccagc cagggcaaca gagggagacc 96360
ctgtctctaa aacaaacaaa caaacaaaca aacaaaagag ttaacattgg ccagattagg 96420
attcaccaga tagtgttaat attagtttga tttgagactt taatcagaaa gcacatgtgt 96480
ggtgggggtg ggtgtaacct aagtcaggta gaatctttcc aacttggggg gggcacactc 96540
ctgattgtag ccatatgagt ctgtcagtgt ggtggaagag accatgggtt aatgggcagg 96600
taaaaaagca ccttgcctgg aattgagtag aaagtaaggc ccttcagacc ccgtgacaca 96660
cttggggaca ttttcttgag taacatccta agattcatgt accttgatga tctccatcaa 96720
cttactcatg tgaagcacct ttaaaccagt cgtctccaaa ttcaggggca cagtaacatc 96780
caacaggctg gagaaagaac gtactagaac ttccattcct ttttcatgtc ctcttctaaa 96840
agctttgtca gggccaggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg 96900
agacgggtgg atcacgaggt caggagatcg agaccatcct ggctaacaca gtgaaacccc 96960
atctctacta aaaatacaaa aaaacgagcc gggcgtggtg gtgggcgcct gtagtcccag 97020
ctactcggga ggctgaggca ggagaatggc gtgaacccag gaggcagagc ttgcagtgag 97080
ccgagattgc accactgcag tccagcctgg gcgacagagc gagactccgt ctcaaaaaag 97140
aaaaagaaaa agaaaaagaa ctgtgattgg ggaggacggt cactttcctg ttcttactga 97200
tcagaaggga tattaagggt acctgattca aacagcctgg agatcactgc tttcaaccat 97260
tacctgcctt atttattttt agttactgtc cttttttcag tttgtttccc tcctccatgt 97320
gctgactttt attttgattt tatttatgtt tatgtttaag acatccacac gttcctctgc 97380
taaaaccttg aaaaataggc cttgccttag ccccaaacac cccactcctg gtagctcaga 97440
ccctctgatc caaccctcca gccctgctgt gtgcccagag ccaccttcct ctcctaaaca 97500
cgtctcttct gtcacttccc gaactggcag ttctggagca aaggagatga aactcaaggt 97560
aaggaaacca cctttgaaaa gaaccaggct gctctgctgt ggtttgcaaa tgtggggttt 97620
gtttatttgt tttttagcct caaagacctt tcttcaaatg agttctggca tagaagcacc 97680
gtgtaaaata gttagaattc tgggcaaagg ggaaaagaga gctgggggcc atccctctca 97740
gcaccccaca ggctctcata gcagcagctc ctaagacacc tggtgggacc ttggtttcga 97800
aatcgctact ctaaggctgg gcacggtggc tcacacctgt aatcccagct ctttaggagg 97860
ccgaggaggg tggatcacct gagatcagga gttcgagacc agcctggcta acatggcaaa 97920
accctgtctc tactaaaaat acaaaaatta gccgggcgtg gtgttatgcg tggtggtaat 97980
cgcagctact cgggaggctg aggcacaagg attgcttgaa ccccagaggc agaggttgta 98040
gttagctcca gcttgggcga cagagcaaga ccctgtcgca aaaattgttt aaaaaacaaa 98100
cccaaaattg ctactctcat tgggttcctt tgcccattcc tgattttggc aagagaaatg 98160
cttccagatt gccctgatct gggtaggaca gcatcacgcc atagcaacac tgccccgtga 98220
gctcactgcc ccctcaacta gcttgtggtc cttggttaat gtcagtttct tttttgagtt 98280
tgtgttatgt ctaagggtca tctgctgggt aacggaaccc agggactgcc ctagtcccta 98340
gactgtgcca tgcccgactc tgccagcttt gtcagtgatg ctggtgctcg cctcctcggg 98400
tgctcgcctg gtctgagcac acccaaggag ttcttgaggc cttagggttg tttgcgagag 98460
aatgaaagaa cacgacctag ctctctttag catccttggt caggttcaac actgccccca 98520
ggggcctctg gtggagccaa ccaccatcag ccaaataaat ccataattag agtcagaaaa 98580
tggatgtctg catatgtgta gtgcactaat gtcctgccga tgattgacat ggagtggaga 98640
gtgacctgat cattgctgtg agctctgctg gccttggcac aactcatgct gataactaat 98700
gcacacagtt cctctgggag gaaatgtcct cagggaactt ggagtttggg tggggatgtg 98760
ggtttgtgtg cccagcaagc ccttgtggtt gtagcagaca ctagtggcat ctaggaggca 98820
aagggtcacc ccagtcttag ccacgttttg agtcaaggtg gcggagtggg gctggtgttg 98880
actcttggtg gcagtaactt ttcccaatgg tgaaaaaccc ctctatcatg tttcatttac 98940
agggggctga tggtaaaacg aagatcgcca caccgcgggg agcagcccct ccaggccaga 99000
agggccaggc caacgccacc aggattccag caaaaacccc gcccgctcca aagacaccac 99060
ccagctctgg taagaagaac gttctcttga atcttagagg aagctgaagc tctcagaggt 99120
acagccttca ttttaggagg ccttaggcca ctgagaatga ataacccctg gcagctggtc 99180
agcagcttgc agtttactaa gcactggagt cttcattgcc ttctcagtcc ttttgatttc 99240
tgaggcaaat gttgaatccc tacctttttt tttttttttc ttttgagaca gagtttcgct 99300
tttgttatcc aggccggagt gcagtggtgt gatctcagct cactgcatcc tccacctccc 99360
aggttcaagc gattctccta cctcagcctc cctagtagct gggattacag gcacctgcca 99420
ctatgcccgg ctaatttttt gtatttttag tagagacagg gtttcaccat gttggccagg 99480
ctggtctcga acgcctgacc tcaggtgatc cacctgcctc ggcctcccaa agtgctggga 99540
ttacaggcat gagccaccac tcccagcctg aatcctcact ttttatcaat gaagaaattg 99600
aggctgattc tgcagcatga taaaaaaaaa tacagaaaaa ggaaaaaaaa gaaagaaatc 99660
gagcctctga gagtttgctt gactgagtct aaccagctca ttttaaaccc gaggaaaatg 99720
cagtcacatg actactaagt ggcagctctc ggagcctctc tggccccaag tccagggttc 99780
catagaggca gccccagcat ggcatgtttt cagtccccaa atgagactct ggagacaaat 99840
gtctctggag acagagcagc agcctggata agtcacaatg ggtgacgtca ctcagggctc 99900
aacccctggg cagcttaact tgctagggac gttaggagtc tgctgcaaaa cctgagggtc 99960
ttagctgagc agtcacaggc tgggcccgtt gccctgggct cctgtgagta aaacccagtc 100020
aattttgagt acccagtaag gcatccattg agttattttg cagccaggag tgctattaag 100080
aacagtcgcg gctgggcgtg gtggctcatg cctgtaatcc cagcactttg ggaggccaag 100140
gtgggcggat cacctgaggt caggagttcg agaccagctt ggccaacatg gcaaaacccc 100200
gtctctaata aaaatacaaa ataattagct gggcgtggtg gcgggcgcct gtaatcccag 100260
cttctcagga gggtgaggaa ggagaatcac ttgaacccag gaggcagagg ttgcagtgag 100320
ctgagatcgc accattgcac tccagcctgg atgacaaaag tgagattcct tctcaaaaaa 100380
aaaaaaaaaa aaacagtcgt cctctttggg gattagggac agcctgcctg cctgcccgag 100440
cacttctctc ttccattgcc ccagtgaagt attccaggcc cctgggttta gactctgcac 100500
catgtagggg tgtctgacct gcacttgctc cttggtggca cgggcagcct atggcacttg 100560
ctgcgggctg tgaccaaagc ctggcctgga tcttggatct tggtgactct gcttctccct 100620
ggcctgaggg agctgcccag agcctgccca ccacctgctg cgtgtctttg cggtggcatt 100680
tctcgcacac atgccgtgcg gtggcacccc caaggatggc cattcactaa ggcccattgt 100740
ttttgtcttt tcgcttcgtg ttttctggcc tggtgttttt ctcatataca tgtgatccag 100800
ggataattcc cagaattttg acaggatttt aagtagcgtt tggatcctgc tgtttttttt 100860
tcacttaaca tcgggccagt tgactcacac tctgtttttt gttgttgttt ttttgagacg 100920
gagtctcact gtgtcaccca ggctgaagtg cagtggcaca atcttggcat actgcaacct 100980
ctgcttccca aattcaagca gttttcctgc ctcagcctcc tgagtagctg ggactacagg 101040
cacaggccac cacgccctgc taatttttgt atttttagta aagacagggt ttcaccattt 101100
tggccagcct agtctcgaac tcctgacctc aagtgatccg cccacctcgg cctcccaaag 101160
tgctgggatt acaggggact cacactttgt aacaacctga aacaacgtga tgcatttccc 101220
tttgggtctt acctgctctt cggtggctgc ctgcaggtgg agagaccctc ccccttgggc 101280
ccctcgacct tgtttcagaa tggggcccct gctgggccag ctgtgggtgc ctgccacgtg 101340
aaggactcat taaggccctg tttaagcctg atgataataa ggctttcgtg gatttttctc 101400
tttaagcgac taagcaagtc cagagaagac caccccctgc agggcccaga tctgagagag 101460
gtactcggga gcctacttcg ctgggagcag cctccctttg cgtgtgtggc cattcactgg 101520
cttgtgtttc tagagccggg aggacccttt tctgcaatgc agggttcaca cagggttcgc 101580
agcctgaaga tggagcagtc cgaattctct tccctgtgca gtttgcgcag ctgtgtttgt 101640
ctgatgggct ttctaatcct gtgtgctctc cttgacttca gggacaatgg cattacaggc 101700
atgagccacc atgcctggct gtctccctat gtttcagatg aagacatagg cttaaggagg 101760
tcaggtgact tgcccacgac cactctgtaa ataagaggca tgaaaagtat ttggagccac 101820
caccaccaag cccactggtc accctgggtc tctgaagtca gggaggcagg aggatgggag 101880
gtctgaggag gcagagaggc tgagcctgga ggccctggag gccgaggccc catctgttgt 101940
ttccttatgt ggaaaataag aggcttcatt tgtcctattg ccacagagcg tactacttca 102000
ggaacatcca agacatggaa atccgcaggg cacggtggct cacgtctata atcccggcac 102060
tttgggaggt tgaggtggga gaatcgcttg aggccagaag ttcaagacca gcctgagcaa 102120
catagtcaga ccccgtctct ataaaaaaca ttatttttaa aaaagacatg gaagtcaaat 102180
tctaaaaact ggtgctggct gggtgcggtg gctcatgcct ataatcccag cactttggga 102240
ggccgaggcg ggtggatcac ctgaggtcag gagttcaaga ccagcctggc caacatggta 102300
aaacctctac taaagaaatc tttactgaaa atacaaaaat ccagtctcta ctaaaataag 102360
tctctactaa aaatacaaaa attagccagg cgtggtgctg cacacctgta atatcagcta 102420
ctcgggaggc tgaggcagga gactcgcttg atcccatgca gcggaggttg cagtgagccg 102480
agatcacgcc attgcactcc agcctgggca tcagaataag actccgtctc aaaaaaaaaa 102540
ccacaaaaaa acaaaacaac aacaaaagaa aactagtgct tattcgtcac tggccaagct 102600
gcccattggc tacatgggtg cttcaaagag ctgcccttct ccaggtctgg ccagcaggta 102660
tgtgttacag caaatgcctg gggcagcggc aggggcattg ctgcgggaag cttctggact 102720
tgcaggaaag ctaagttctc agactgcagg ggagctaagc acacctcggc acagggtgag 102780
gcctgcggtt ctcagacttc agtctttgtg gagcttgaga aaaatgaggc tttgcaggtc 102840
ccacccctag agattctgct ctatccactc ttgaagggga tcgagaaatt tgcattttgc 102900
aactcccact ttcctccttg aaagctccgg agattctgac gcagggttcc gtgggccaca 102960
ctttggaaaa tacagaccca tgagatagaa taccagactg ttgaagtgta acgggggcct 103020
gggaagtgca gtaacagaag caagtttgag ggtaaaggac acccagagga gggagggaca 103080
gcatctgcat ggagaggaga agagaccccc cagcagcttc cagggtgttg gaagggtgcg 103140
ctagtaactg ctatgcatgg caggtgggga actgtacgtc agggcacagc agcatgaagc 103200
ggtatggctc gtgtggacag ctagggacag gcaggcgtgg agcaggcatc ctgttctgaa 103260
ggccaaatcc cacagaggag ccagggtgct ggcaggagcc ctgaactagc cgaacagctg 103320
aacagctgaa cattcaccct gtggggaaag ggtcagaagc gtccaggctt gagggcacag 103380
ctgggtctcg tcactgcatc acccttattt aggataaagg ccctgaagaa ttgtattaga 103440
ggttggcaaa gcatatctac cacctcctgg agccacgctg gccgcaggga ttataattat 103500
ttccattttc aaattaaggc ctctgagctc agagagggga agttacttgt ctgaggccac 103560
acagcttgtt ggagcccatc tcttgaccca aagactgtgg agccgagttg gccacctctc 103620
tgggagcggg tattggatgg tggttgatgg ttttccattg ctttcctggg aaaggggtgt 103680
ctctgtccct aagcaaaaag gcagggagga agagatgctt ccccagggca gccgtctgct 103740
gtagctgcgc ttccaacctg gcttccacct gcctaaccca gtggtgagcc tgggaatgga 103800
cccacgggac aggcagcccc cagggccttt tctgacccca cccactcgag tcctggcttc 103860
actcccttcc ttccttccca ggtgaacctc caaaatcagg ggatcgcagc ggctacagca 103920
gccccggctc cccaggcact cccggcagcc gctcccgcac cccgtccctt ccaaccccac 103980
ccacccggga gcccaagaag gtggcagtgg tccgtactcc acccaagtcg ccgtcttccg 104040
ccaagagccg cctgcagaca gcccccgtgc ccatgccaga cctgaagaat gtcaagtcca 104100
agatcggctc cactgagaac ctgaagcacc agccgggagg cgggaaggtg agagtggctg 104160
gctgcgcgtg gaggtgtggg gggctgcgcc tggaggggta gggctgtgcc tggaagggta 104220
gggctgcgcc tggaggtgcg cggttgagcg tggagtcgtg ggactgtgca tggaggtgtg 104280
gggctccccg cacctgagca cccccgcata acaccccagt cccctctgga ccctcttcaa 104340
ggaagttcag ttctttattg ggctctccac tacactgtga gtgccctcct caggcgagag 104400
aacgttctgg ctcttctctt gccccttcag cccctgttaa tcggacagag atggcagggc 104460
tgtgtctcca cggccggagg ctctcatagt cagggcaccc acagcggttc cccacctgcc 104520
ttctgggcag aatacactgc cacccatagg tcagcatctc cactcgtggg ccatctgctt 104580
aggttgggtt cctctggatt ctggggagat tgggggttct gttttgatca gctgattctt 104640
ctgggagcaa gtgggtgctc gcgagctctc cagcttccta aaggtggaga agcacagact 104700
tcgggggcct ggcctggatc cctttcccca ttcctgtccc tgtgcccctc gtctgggtgc 104760
gttagggctg acatacaaag caccacagtg aaagaacagc agtatgcctc ctcactagcc 104820
aggtgtgggc gggtgggttt cttccaaggc ctctctgtgg ccgtgggtag ccacctctgt 104880
cctgcaccgc tgcagtcttc cctctgtgtg tgctcctggt agctctgcgc atgctcatct 104940
tcttataaga acaccatggc agctgggcgt agtggctcac gcctataatc ccagcacttt 105000
gggaggctga ggcaggcaga tcacgaggtc aggagttcga gaccaacctg accaacaggg 105060
tgaaacctcg tctctactaa aaatacaaaa atacctgggc gtggtggtgg tgcgcgccta 105120
taatcccagc tactcaggag gctgaggcag gagaatcgct tgaacccagg aggcagaggt 105180
tgcagtgagc cgagatagtg ccactgcact ccagtttgag caacagagcg agactctgtc 105240
tcaaaacaaa ataaaacaaa ccaaaaaaac ccaccatggc ttagggccca gcctgatgac 105300
ctcatttttc acttagtcac ctctctaaag gccctgtctc caaatagagt cacattctaa 105360
ggtacggggg tgttggggag gggggttagg gcttcaacat gtgaatttgc ggggaccaca 105420
attcagccca ggaccccgct cccgccaccc agcactgggg agctggggaa gggtgaagag 105480
gaggctgggg gtgagaagga ccacagctca ctctgaggct gcagatgtgc tgggccttct 105540
gggcactggg cctcggggag ctagggggct ttctggaacc ctgggcctgc gtgtcagctt 105600
gcctccccca cgcaggcgct ctccacacca ttgaagttct tatcacttgg gtctgagcct 105660
ggggcatttg gacggagggt ggccaccagt gcacatgggc accttgcctc aaaccctgcc 105720
acctcccccc acccaggatc ccccctgccc ccgaacaagc ttgtgagtgc agtgtcacat 105780
cccatcggga tggaaatgga cggtcgggtt aaaagggacg catgtgtaga ccctgcctct 105840
gtgcatcagg cctcttttga gagtccctgc gtgccaggcg gtgcacagag gtggagaaga 105900
ctcggctgtg ccccagagca cctcctctca tcgaggaaag gacagacagt ggctcccctg 105960
tggctgtggg gacaagggca gagctccctg gaacacagga gggagggaag gaagagaaca 106020
tctcagaatc tccctcctga tggcaaacga tccgggttaa attaaggtcc ggccttttcc 106080
tgctcaggca tgtggagctt gtagtggaag aggctctctg gaccctcatc caccacagtg 106140
gcctggttag agaccttggg gaaataactc acaggtgacc cagggcctct gtcctgtacc 106200
gcagctgagg gaaactgtcc tgcgcttcca ctggggacaa tgcgctccct cgtctccaga 106260
ctttccagtc ctcattcggt tctcgaaagt cgcctccaga agccccatct tgggaccacc 106320
gtgactttca ttctccaggg tgcctggcct tggtgctgcc caagacccca gaggggccct 106380
cactggcctt tcctgccttt tctcccattg cccacccatg cacccccatc ctgctccagc 106440
acccagactg ccatccagga tctcctcaag tcacataaca agcagcaccc acaaggtgct 106500
cccttccccc tagcctgaat ctgctgctcc ccgtctgggg ttccccgccc atgcacctct 106560
gggggcccct gggttctgcc ataccctgcc ctgtgtccca tggtggggaa tgtccttctc 106620
tccttatctc ttcccttccc ttaaatccaa gttcagttgc catctcctcc aggaagtctt 106680
cctggattcc cctctctctt cttaaagccc ctgtaaactc tgaccacact gagcatgtgt 106740
ctgctgctcc ctagtctggg ccatgagtga gggtggaggc caagtctcat gcatttttgc 106800
agcccccaca agactgtgca ggtggccggc cctcattgaa tgcggggtta atttaactca 106860
gcctctgtgt gagtggatga ttcaggttgc cagagacaga accctcagct tagcatggga 106920
agtagcttcc ctgttgaccc tgagttcatc tgaggttggc ttggaaggtg tgggcaccat 106980
ttggcccagt tcttacagct ctgaagagag cagcaggaat ggggctgagc agggaagaca 107040
actttccatt gaaggcccct ttcagggcca gaactgtccc tcccaccctg cagctgccct 107100
gcctctgccc atgaggggtg agagtcaggc gacctcatgc caagtgtaga aaggggcaga 107160
cgggagcccc aggttatgac gtcaccatgc tgggtggagg cagcacgtcc aaatctacta 107220
aagggttaaa ggagaaaggg tgacttgact tttcttgaga tattttgggg gacgaagtgt 107280
ggaaaagtgg cagaggacac agtcacagcc tcccttaaat gccaggaaag cctagaaaaa 107340
ttgtctgaaa ctaaacctca gccataacaa agaccaacac atgaatctcc aggaaaaaag 107400
aaaaagaaaa atgtcataca gggtccatgc acaagagcct ttaaaatgac ccgctgaagg 107460
gtgtcaggcc tcctcctcct ggactggcct gaaggctcca cgagcttttg ctgagacctt 107520
tgggtccctg tggcctcatg tagtacccag tatgcagtaa gtgctcaata aatgtttggc 107580
tacaaaagag gcaaagctgg cggagtctga agaatccctc aaccgtgccg gaacagatgc 107640
taacaccaaa gggaaaagag caggagccaa gtcacgtttg ggaacctgca gaggctgaaa 107700
actgccgcag attgctgcaa atcattgggg gaaaaacgga aaacgtctgt tttccccttt 107760
gtgcttttct ctgttttctt ctttgtgctt ttctctgttt tcaggatttg ctacagtgaa 107820
catagattgc tttggggccc caaatggaat tattttgaaa ggaaaatgca gataatcagg 107880
tggccgcact ggagcaccag ctgggtaggg gtagagattg caggcaagga ggaggagctg 107940
ggtggggtgc caggcaggaa gagcccgtag gccccgccga tcttgtggga gtcgtgggtg 108000
gcagtgttcc ctccagactg taaaagggag cacctggcgg gaagagggaa ttcttttaaa 108060
catcattcca gtgcccgagc ctcctggacc tgttgtcatc ttgaggtggg cctcccctgg 108120
gtgactctag tgtgcagcct ggctgagact cagtggccct gggttcttac tgctgacacc 108180
taccctcaac ctcaaccact gcggcctcct gtgcaccctg atccagtggc tcattttcca 108240
ctttcagtcc cagctctatc cctatttgca gtttccaagt gcctggtcct cagtcagctc 108300
agacccagcc aggccagccc ctggttccca catccccttt gccaagctca tccccgccct 108360
gtttggcctg cgggagtggg agtgtgtcca gacacagaga caaaggacca gcttttaaaa 108420
cattttgttg gggccaggtg tggtggctca cacctaatcc caacacctgg ggaggccaag 108480
gcagaaggat cacttgagtc caggagttca agaccagcct gggcaacata gggagaccct 108540
gtctctacaa tttttttttt aattagctgg gcctgttggc actctcctgt agttccagct 108600
actctagagg ctgaggtggg aggactgctt gagcctggga ggtcagggct gcaatgagcc 108660
atgttcacac cactgaacgc cagcctgggc gagaccctgt atcaaaaaag taaagtaaaa 108720
tgaatcctgt acgttatatt aaggtgcccc aaattgtact tagaaggatt tcatagtttt 108780
aaatactttt gttatttaaa aaattaaatg actgcagcat ataaattagg ttcttaatgg 108840
aggggaaaaa gagtacaaga aaagaaataa gaatctagaa acaaagataa gagcagaaat 108900
aaaccagaaa acacaacctt gcactcctaa cttaaaaaaa aaaatgaaga aaacacaacc 108960
agtaaaacaa catataacag cattaagagc tggctcctgg ctgggcgcgg tggcgcatgc 109020
ctgtaatccc aacactttgg gaggccgatg ctggaggatc acttgagacc aggagttcaa 109080
ggttgcagtg agctatgatc ataccactac accctagcct gggcaacaca gtgagactga 109140
gactctatta aaaaaaaaat gctggttcct tccttatttc attcctttat tcattcattc 109200
agacaacatt tatggggcac ttctgagcac caggctctgt gctaagagct tttgccccca 109260
gggtccaggc caggggacag gggcaggtga gcagagaaac agggccagtc acagcagcag 109320
gaggaatgta ggatggagag cttggccagg caaggacatg cagggggagc agcctgcaca 109380
agtcagcaag ccagagaaga caggcagacc cttgtttggg acctgttcag tggcctttga 109440
aaggacagcc cccacccgga gtgctgggtg caggagctga aggaggatag tggaacactg 109500
caacgtggag ctcttcagag caaaagcaaa ataaacaact ggaggcagct ggggcagcag 109560
agggtgtgtg ttcagcacta aggggtgtga agcttgagcg ctaggagagt tcacactggc 109620
agaagagagg ttggggcagc tgcaagcctc tggacatcgc ccgacaggac agagggtggt 109680
ggacggtggc cctgaagaga ggctcagttc agctggcagt ggccgtggga gtgctgaagc 109740
aggcaggctg tcggcatctg ctggggacgg ttaagcaggg gtgagggccc agcctcagca 109800
gcccttcttg gggggtcgct gggaaacata gaggagaact gaagaagcag ggagtcccag 109860
ggtccatgca gggcgagaga gaagttgctc atgtggggcc caggctgcag gatcaggaga 109920
actggggacc ctgtgactgc cagcggggag aagggggtgt gcaggatcat gcccagggaa 109980
gggcccaggg gcccaagcat gggggggcct ggttggctct gagaagatgg agctaaagtc 110040
actttctcgg aggatgtcca ggccaatagt tgggatgtga agacgtgaag cagcacagag 110100
cctggaagcc caggatggac agaaacctac ctgagcagtg gggctttgaa agccttgggg 110160
cggggggtgc aatattcaag atggccacaa gatggcaata gaatgctgta actttcttgg 110220
ttctgggccg cagcctgggt ggctgcttcc ttccctgtgt gtattgattt gtttctcttt 110280
tttgagacag agtcttgctg ggttgcccag gctggagtgc agtggtgcga tcatagctca 110340
ctgcagcctt gaagtcctga gctcaagaga tccttccacc tcagcctcct gagtagttgg 110400
gaccacaggc ttgcaccaca gtgcccaact aatttcttat attttttgta gagatggggt 110460
ttcactgtgt cgcccaggat ggtcttgaac tcctgggctc aagtgatcct cctgcctcag 110520
cctcgcaaat tgctgggatt acaggtgtga gccaccatgc ccgaccttct ctttttaagg 110580
gcgtgtgtgt gtgtgtgtgt gtgtgggcgc actctcgtct tcaccttccc ccagccttgc 110640
tctgtctcta cccagtcacc tctgcccatc tctccgatct gtttctctct ccttttaccc 110700
ctctttcctc cctcctcata caccactgac cattatagag aactgagtat tctaaaaata 110760
cattttattt atttattttg agacagagtc tcactctgtc acccaggctg gagtgcagtg 110820
gtgcaatctc ggctcactgc aacctccgcc tcccaggttg aagcaactct cctgcctcag 110880
cctccctagt agctgggatt acaagcacac accaccatgc ctagcaaatt tttatatttt 110940
tagtagagga ggagtgtcac catgtttgcc aagctggtct caaactcctg gcctcaggtg 111000
atctgcctac cttggtctcc caaagtgctg ggattacagg tgtgagccac cacgcctgcc 111060
cttaaaaata cattatattt aatagcaaag ccccagttgt cactttaaaa agcatctatg 111120
tagaacattt atgtggaata aatacagtga atttgtacgt ggaatcgttt gcctctcctc 111180
aatcagggcc agggatgcag gtgagcttgg gctgagatgt cagaccccac agtaagtggg 111240
gggcagagcc aggctgggac cctcctctag gacagctctg taactctgag accctccagg 111300
catcttttcc tgtacctcag tgcttctgaa aaatctgtgt gaatcaaatc attttaaagg 111360
agcttgggtt catcactgtt taaaggacag tgtaaataat tctgaaggtg actctaccct 111420
gttatttgat ctcttctttg gccagctgac ttaacaggac atagacaggt tttcctgtgt 111480
cagttcctaa gctgatcacc ttggacttga agaggaggct tgtgtgggca tccagtgccc 111540
accccgggtt aaactcccag cagagtattg cactgggctt gctgagcctg gtgaggcaaa 111600
gcacagcaca gcgagcacca ggcagtgctg gagacaggcc aagtctgggc cagcctggga 111660
gccaactgtg aggcacggac ggggctgtgg ggctgtgggg ctgcaggctt ggggccaggg 111720
agggagggct gggctctttg gaacagcctt gagagaactg aacccaaaca aaaccagatc 111780
aaggtctagt gagagcttag ggctgctttg ggtgctccag gaaattgatt aaaccaagtg 111840
gacacacacc cccagcccca cctcaccaca gcctctcctt cagggtcaaa ctctgaccac 111900
agacatttct cccctgacta ggagttccct ggatcaaaat tgggagcttg caacacatcg 111960
ttctctccct tgatggtttt tgtcagtgtc tatccagagc tgaagtgtaa tatatatgtt 112020
actgtagctg agaaattaaa tttcaggatt ctgatttcat aatgacaacc attcctcttt 112080
tctctccctt ctgtaaatct aagattctat aaacggtgtt gacttaatgt gacaattggc 112140
agtagttcag gtctgctttg taaataccct tgtgtctatt gtaaaatctc acaaaggctt 112200
gttgcctttt ttgtggggtt agaacaagaa aaagccacat ggaaaaaaaa tttctttttt 112260
gtttttttgt ttgcttgttt ttttgagaca gagtttcact ctgtcgccca ggctggagtg 112320
cagtggtgcg atctccgccc actgcaagct ccacctcccg ggttcatgct attctcctgt 112380
ctcagcctcc caagtagctg ggactgcagg tgcccgccac cacacctggc taattttttt 112440
gtatttttag tagagacggg gtttcaccgt gttagccagg atggtctcaa tctcctgacc 112500
tcgtcatctg cctgcctcgg cctcccaaag tgctgagatt acaggcgtga gccaccgtgc 112560
ccggccagaa aaaaacattt ctaagtatgt ggcagatact gaattattgc ttaatgtcct 112620
ttgattcatt tgtttaattt ctttaatgga ttagtacaga aaacaaagtt ctcttccttg 112680
aaaaactggt aagttttctt tgtcagataa ggagagttaa ataacccatg acatttccct 112740
ttttgcctcg gcttccagga agctcaaagt taaatgtaat gatcactctt gtaattatca 112800
gtgttgatgc ccttcccttc ttctaatgtt actctttaca ttttcctgct ttattattgt 112860
gtgtgttttc taattctaag ctgttcccac tcctttctga aagcaggcaa atcttctaag 112920
ccttatccac tgaaaagtta tgaataaaaa atgatcgtca agcctacagg tgctgaggct 112980
actccagagg ctgaggccag aggaccactt gagcccagga atttgagacc tgggctgggc 113040
agcatagcaa gactctatct ccattaaaac tatttttttt tatttaaaaa ataatccgca 113100
aagaaggagt ttatgtggga ttccttaaaa tcggagggtg gcatgaattg attcaaagac 113160
ttgtgcagag ggcgacagtg actccttgag aagcagtgtg agaaagcctg tcccacctcc 113220
ttccgcagct ccagcctggg ctgaggcact gtcacagtgt ctccttgctg gcaggagaga 113280
atttcaacat tcaccaaaaa gtagtattgt ttttattagg tttatgaggc tgtagccttg 113340
aggacagccc aggacaactt tgttgtcaca tagatagcct gtggctacaa actctgagat 113400
ctagattctt ctgcggctgc ttctgacctg agaaagttgc ggaacctcag cgagcctcac 113460
atggcctcct tgtccttaac gtggggacgg tgggcaagaa aggtgatgtg gcactagaga 113520
tttatccatc tctaaaggag gagtggattg tacattgaaa caccagagaa ggaattacaa 113580
aggaagaatt tgagtatcta aaaatgtagg tcaggcgctc ctgtgttgat tgcagggcta 113640
ttcacaatag ccaagatttg gaagcaaccc aagtgtccat caacagacaa atggataaag 113700
aaaatgtggt gcatatacac aatggaatac tattcagcca tgaaaaagaa tgagaatctg 113760
tcatttgaaa caacatggat ggaactggag gacattatgt taagtgaaat aagccagaca 113820
gaaggacaga cttcacatgt tctcacacat ttgtgggagc taaaaattaa actcatggag 113880
atagagagta gaaggatggt taccagaggc tgaggagggt ggaggggagc agggagaaag 113940
tagggatggt taatgggtac aaaaacgtag ttagcatgca tagatctagt attggatagc 114000
acagcagggt gacgacagcc aacagtaatt tatagtacat ttaaaaacaa ctaaaagagt 114060
gtaactggac tggctaacat ggtgaaaccc cgtctctact aaaaatacaa aaattagctg 114120
ggcacggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg gccgatcacg 114180
aggtcaggag atcgagacca tcctagctaa catggtgaaa ccccgtctct actacaaata 114240
caaaaaaaag aaaaaattag ccgggcatgg tggtgggcgc ctgtagtccc agctactcgg 114300
gaggctgagg caggagaatg gcgtgaaccc gggaggcgga gcttgcagtg agccgagatc 114360
gcgccactgc actccagcct gggcgacaag gcaagattct atctcaaaaa aataaaaata 114420
aaataaaata aaataataaa ataaaataaa ataaaataaa ataaaataaa taaaataaaa 114480
tgtataattg gaatgtttat aacacaagaa atgataaatg cttgaggtga tagatacccc 114540
attcaccgtg atgtgattat tgcacaatgt atgtctgtat ctaaatatct catgtacccc 114600
acaagtatat acacctacta tgtacccata taaatttaaa attaaaaaat tataaaacaa 114660
aaataaataa gtaaattaaa atgtaggctg gacaccgtgg ttcacgcctg taatcccagt 114720
gctttgtgag gctgaggtga gagaatcact tgagcccagg agtttgagac cggcctgggt 114780
gacatagcga gaccccatca tcacaaagaa tttttaaaaa ttagctgggc gtggtagcac 114840
ataccggtag ttccagctac ttgggagacc gaggcaggag gattgcttga gcccaggagt 114900
ttaaggctgc agtgagctac gatggcgcca ctgcattcca gcctgggtga cagagtgaga 114960
gcttgtctct attttaaaaa taataaaaag aataaataaa aataaattaa aatgtaaata 115020
tgtgcatgtt agaaaaaata cacccatcag caaaaagggg gtaaaggagc gatttcagtc 115080
ataattggag agatgcagaa taagccagca atgcagtttc ttttattttg gtcaaaaaaa 115140
ataagcaaaa caatgttgta aacacccagt gctggcagca atgtggtgag gctggctctc 115200
tcaccagggc tcacagggaa aactcatgca acccttttag aaagccatgt ggagagttgt 115260
accgagaggt tttagaatat ttataacttt gacccagaaa ttctattcta ggactctgtg 115320
ttatgaaaat aacccatcat atggaaaaag ctcctttcag aaagaggttc atgggaggct 115380
gtttgtattt tttttttctt tgcatcaaat ccagctcctg caggactgtt tgtattattg 115440
aagtacaaag tggaatcaat acaaatgttg gatagcaggg gaacaatatt cacaaaatgg 115500
aatgggacat agtattaaac atagtgcttc tgatgaccgt agaccataga caatgcttag 115560
gatatgatat cacttctttt gttgtttttt gtattttgag acgaagtctc attctgtcac 115620
ccaggctgga gttcagtggc gccatctcag ctcactgcaa cctccatctc ccgggttcaa 115680
gctattctcc ttcctcaacc tcccgagtag ctgggttgcg caccaccatg cctggctaac 115740
ttttgtattt ttagtacaga cggggtttca ccacgttggc caggctgctc ttgaactcct 115800
gacgtcaggt gatccaccag ccttgacctc ccaaagtgct aggattacag gagccactgt 115860
acccagccta ggatatgata tcacttctta gagcaagata caaaattgca tgtgcacaat 115920
aattctacca agtataggta tacaggggta gttatatata aatgagactt caaggaaata 115980
caacaaaatg caatcgtgat tgtgttaggg tggtaagaaa acggtttttg ctttgatgag 116040
ctctgttttt taaaatcgtt atattttcta ataaaaatac atagtctttt gaaggaacat 116100
aaaagattat gaagaaatga gttagatatt gattcctatt gaagattcag acaagtaaaa 116160
ttaaggggaa aaaaaacggg atgaaccaga agtcaggctg gagttccaac cccagatccg 116220
acagcccagg ctgatggggc ctccagggca gtggtttcca cccagcattc tcaaaagagc 116280
cactgaggtc tcagtgccat tttcaagatt tcggaagcgg cctgggcacg gctggtcctt 116340
cactgggatc accacttggc aattatttac acctgagacg aatgaaaacc agagtgctga 116400
gattacaggc atggtggctt acgcttgtaa tcggctttgg gaagccgagg tgggctgatt 116460
gcttgagccc aggagtttca aactatcctg gacaacatag catgacctcg tctctacaaa 116520
aaatacaaaa aatttgccag gtgtggtggc atgtgcctgt ggtcccagct acttgggagg 116580
ctgaagtagg agaatcccct gagccctggg aagtcgaggc tgcactgagc cgtgatggtg 116640
tcactgcact ccagcctggg tgacaaagtg agaccctatc tcacaaagaa aaaaaacaaa 116700
acaaaaaacc caaagcacac tgtttccact gtttccagag ttcctgagag gaaaggtcac 116760
cgggtgagga agacgttctc actgatctgg cagagaaaat gtccagtttt tccaactccc 116820
taaaccatgg ttttctattt catagttctt aggcaaattg gtaaaaatca tttctcatca 116880
aaacgctgat attttcacac ctccctggtg tctgcagaaa gaaccttcca gaaatgcagt 116940
cgtgggagac ccatccaggc cacccctgct tatggaagag ctgagaaaaa gccccacggg 117000
agcatttgct cagcttccgt tacgcaccta gtggcattgt gggtgggaga gggctggtgg 117060
gtggatggaa ggagaaggca cagccccccc ttgcagggac agagccctcg tacagaaggg 117120
acaccccaca tttgtcttcc ccacaaagcg gcctgtgtcc tgcctacggg gtcagggctt 117180
ctcaaacctg gctgtgtgtc agaatcacca ggggaacttt tcaaaactag agagactgaa 117240
gccagactcc tagattctaa ttctaggtca gggctagggg ctgagattgt aaaaatccac 117300
aggtgattct gatgcccggc aggcttgaga acagccgcag ggagttctct gggaatgtgc 117360
cggtgggtct agccaggtgt gagtggagat gccggggaac ttcctattac tcactcgtca 117420
gtgtggccga acacattttt cacttgacct caggctggtg aacgctcccc tctggggttc 117480
aggcctcacg atgccatcct tttgtgaagt gaggacctgc aatcccagct tcgtaaagcc 117540
cgctggaaat cactcacact tctgggatgc cttcagagca gccctctatc ccttcagctc 117600
ccctgggatg tgactcgacc tcccgtcact ccccagactg cctctgccaa gtccgaaagt 117660
ggaggcatcc ttgcgagcaa gtaggcgggt ccagggtggc gcatgtcact catcgaaagt 117720
ggaggcgtcc ttgcgagcaa gcaggcgggt ccagggtggc gtgtcactca tccttttttc 117780
tggctaccaa aggtgcagat aattaataag aagctggatc ttagcaacgt ccagtccaag 117840
tgtggctcaa aggataatat caaacacgtc ccgggaggcg gcagtgtgag taccttcaca 117900
cgtcccatgc gccgtgctgt ggcttgaatt attaggaagt ggtgtgagtg cgtacacttg 117960
cgagacactg catagaataa atccttcttg ggctctcagg atctggctgc gacctctggg 118020
tgaatgtagc ccggctcccc acattccccc acacggtcca ctgttcccag aagccccttc 118080
ctcatattct aggagggggt gtcccagcat ttctgggtcc cccagcctgc gcaggctgtg 118140
tggacagaat agggcagatg acggaccctc tctccggacc ctgcctggga agctgagaat 118200
acccatcaaa gtctccttcc actcatgccc agccctgtcc ccaggagccc catagcccat 118260
tggaagttgg gctgaaggtg gtggcacctg agactgggct gccgcctcct cccccgacac 118320
ctgggcaggt tgacgttgag tggctccact gtggacaggt gacccgtttg ttctgatgag 118380
cggacaccaa ggtcttactg tcctgctcag ctgctgctcc tacacgttca aggcaggagc 118440
cgattcctaa gcctccagct tatgcttagc ctgcgccacc ctctggcaga gactccagat 118500
gcaaagagcc aaaccaaagt gcgacaggtc cctctgccca gcgttgaggt gtggcagaga 118560
aatgctgctt ttggcccttt tagatttggc tgcctcttgc caggagtggt ggctcgtgcc 118620
tgtaattcca gcactttggg agactaaggc gggaggttcg cttgagccca ggagttcaag 118680
accagcctgg gcaacaatga gacccctgtg tctacaaaaa gaattaaaat tagccaggtg 118740
tggtggcacg cacctgtagt cccagctact tgggaggctg aggtgggagg attgcctgag 118800
tccgggaggc ggaagttgca aggagccatg atcgcgccac tgcacttcaa cctaggcaac 118860
agagtgagac tttgtctcaa aaaacaatca tataataatt ttaaaataaa tagatttggc 118920
ttcctctaaa tgtccccggg gactccgtgc atcttctgtg gagtgtctcc gtgagattcg 118980
ggactcagat cctcaagtgc aactgaccca cccgataagc tgaggcttca tcatcccctg 119040
gccggtctat gtcgactggg cacccgaggc tcctctccca ccagctctct tggtcagctg 119100
aaagcaaact gttaacaccc tggggagctg gacgtatgag acccttgggg tgggaggcgt 119160
tgatttttga gagcaatcac ctggccctgg ctggcagtac cgggacactg ctgtggctcc 119220
ggggtgggct gtctccagaa aatgcctggc ctgaggcagc cacccgcatc cagcccagag 119280
ggtttattct tgcaatgtgc tgctgcttcc tgccctgagc acctggatcc cggcttctgc 119340
cctgaggccc cttgagtccc acaggtagca agcgcttgcc ctgcggctgc tgcatggggc 119400
taactaacgc ttcctcacca gtgtctgcta agtgtctcct ctgtctccca cgccctgctc 119460
tcctgtcccc ccagtttgtc tgctgtgagg ggacagaaga ggtgtgtgcc gcccccaccc 119520
ctgcccgggc ccttgttcct gggattgctg ttttcagctg tttgagcttt gatcctggtt 119580
ctctggcttc ctcaaagtga gctcggccag aggaggaagg ccatgtgctt tctggttgaa 119640
gtcaagtctg gtgccctggt ggaggctgtg ctgctgaggc ggagctgggg agagagtgca 119700
cacgggctgc gtggccaacc cctctgggta gctgatgccc aaagacgctg cagtgcccag 119760
gacatctggg acctccctgg ggcccgcccg tgtgtcccgc gctgtgttca tctgcgggct 119820
agcctgtgac ccgcgctgtg ctcgtctgcg ggctagcctg tgtcccgcgc tctgcttgtc 119880
tgcggtctag cctgtgacct ggcagagagc caccagatgt cccgggctga gcactgccct 119940
ctgagcacct tcacaggaag cccttctcct ggtgagaaga gatgccagcc cctggcatct 120000
gggggcactg gatccctggc ctgagcccta gcctctcccc agcctggggg ccccttccca 120060
gcaggctggc cctgctcctt ctctacctgg gacccttctg cctcctggct ggaccctgga 120120
agctctgcag ggcctgctgt ccccctccct gccctccagg tatcctgacc accggccctg 120180
gctcccactg ccatccactc ctctcctttc tggccgttcc ctggtccctg tcccagcccc 120240
cctccccctc tcacgagtta cctcacccag gccagaggga agagggaagg aggccctggt 120300
cataccagca cgtcctccca cctccctcgg ccctggtcca ccccctcagt gctggcctca 120360
gagcacagct ctctccaagc caggccgcgc gccatccatc ctccctgtcc cccaacgtcc 120420
ttgccacaga tcatgtccgc cctgacacac atgggtctca gccatctctg ccccagttaa 120480
ctccccatcc ataaagagca catgccagcc gacaccaaaa taattcggga tggttccagt 120540
ttagacctaa gtggaaggag aaaccaccac ctgccctgca ccttgttttt tggtgacctt 120600
gataaaccat cttcagccat gaagccagct gtctcccagg aagctccagg gcggtgcttc 120660
ctcgggagct gactgatagg tgggaggtgg ctgccccctt gcaccctcag gtgaccccac 120720
acaaggccac tgctggaggc cctggggact ccaggaatgt caatcagtga cctgcccccc 120780
aggccccaca cagccatggc tgcatagagg cctgcctcca agggacctgt ctgtctgcca 120840
ctgtggagtc cctacagcgt gccccccaca ggggagctgg ttctttgact gagatcagct 120900
ggcagctcag ggtcatcatt cccagaggga gcggtgccct ggaggccaca ggcctcctca 120960
tgtgtgtctg cgtccgctcg agcttactga gacactaaat ctgttggttt ctgctgtgcc 121020
acctacccac cctgttggtg ttgctttgtt cctattgcta aagacaggaa tgtccaggac 121080
actgagtgtg caggtgcctg ctggttctca cgtccgagct gctgaactcc gctgggtcct 121140
gcttactgat ggtctttgct ctagtgcttt ccagggtccg tggaagcttt tcctggaata 121200
aagcccacgc atcgaccctc acagcgcctc ccctctttga ggcccagcag ataccccact 121260
cctgcctttc cagcaagatt tttcagatgc tgtgcatact catcatattg atcacttttt 121320
tcttcatgcc tgattgtgat ctgtcaattt catgtcagga aagggagtga catttttaca 121380
cttaagcgtt tgctgagcaa atgtctgggt cttgcacaat gacaatgggt ccctgttttt 121440
cccagaggct cttttgttct gcagggattg aagacactcc agtcccacag tccccagctc 121500
ccctggggca gggttggcag aatttcgaca acacattttt ccaccctgac taggatgtgc 121560
tcctcatggc agctgggaac cactgtccaa taagggcctg ggcttacaca gctgcttctc 121620
attgagttac acccttaata aaataatccc attttatcct ttttgtctct ctgtcttcct 121680
ctctctctgc ctttcctctt ctctctcctc ctctctcatc tccaggtgca aatagtctac 121740
aaaccagttg acctgagcaa ggtgacctcc aagtgtggct cattaggcaa catccatcat 121800
aaaccaggta gccctgtgga aggtgagggt tgggacggga gggtgcaggg ggtggaggag 121860
tcctggtgag gctggaactg ctccagactt cagaaggggc tggaaaggat attttaggta 121920
gacctacatc aaggaaagtg ttgagtgtga aacttgcggg agcccaggag gcgtggtggc 121980
tccagctcgc tcctgcccag gccatgctgc ccaagacaag gtgaggcggg agtgaagtga 122040
aataaggcag gcacagaaag aaagcacata ttctcggccg ggcgctgtgg ctcacgcctg 122100
taattccagc actttgggag gccaaggtgg gtggatcatg aggtcaggag attgagacca 122160
tcctggctaa cacagtgaaa ccccgtctct actaaaaata caaaaaatta gccgggcgtg 122220
gtggtgggcg cctgtagtcc cagctactcc ggaggctgag gcaggaaaat ggcgtgaacc 122280
cggaaggcgg agcttgcagt gagcggagtg agcagagatc gcgccactgc actccagcct 122340
gggcgacaga gcgagactcc gtctcaaaaa aaaaaagcac atgttctcgc ttctttgtgg 122400
gatccaggag atagagaata gaaggatggt taccagaggc tgggaagggt agtgagggga 122460
tggtgggggg atggtcaatg ggtacaaaaa aaatagaata agacctagta tttgatagtg 122520
caacagggtg actatagtca ataataattt aattgtacat ttaaaaataa ctaaaagata 122580
gccgggtgca gtggcttacg tctgtaatcc cagtactttg ggaggctgag gtgggcgttt 122640
gagaccagcc tggccaacat ggtgaaaccc catctctact aaaaatacaa aaattagcca 122700
ggcatggtgg cgggcgcctg taatcccagc tactcgggag gctgaggcag gagaatcact 122760
tgaacctggg aggcagaggt tgcagtgagc cgagatcttg ccactgcact ccagcctggg 122820
tgacagtgaa actccgtctc aaaaataaaa ataaaaatac agctgggcac ggtggctcac 122880
gcctgtaatc ccagcacttt gggaggccga ggcgagcgga tcacaaggtc aggagatata 122940
gaccatcctg gctaacacgg tgaaacccgg tctctactaa aaatacaaaa aattagccag 123000
gcgtggtggc aggtgcctat agtcccagct actcacaagg ctgaggcagg agaatggcat 123060
gaacctggga ggcggagctt gcagtgagcc gagattgtgc cactgcactc cagcctgggc 123120
gagagagtga gactccgtct caaaacaaaa acaaaaacaa aaacaaaaac aaacacacaa 123180
caaaaaccta aaagaatata aatggattgt ttgtaacaca aaggacaaat gtttgagggg 123240
atggataccc cattttccat gatgtgatta ttatacattg tgtgtctgta tcaaaacatc 123300
tcatgagccc cataaatata tacacctaac tatgtaccca caaaaattaa aaaaatatat 123360
tttttaaggt gaagagggag gcgagatgct ggccttaacc cctaacccgt tgttctccct 123420
gcaagctgtc cacagggcct ctcagactcg aggttcagct atatggatgc atgagcttgg 123480
tccccagcca acatgggaga cacttcacca tcggcagcag ctacagcaca ggaaccctgg 123540
gtcactgcca tgtcccctct gtgactttgt ttaaacagaa aatgatgctc tgggccggct 123600
gtggtggccc acacctataa tcccagcacc ttgggaggcg ggggtgggca gattgcctga 123660
ggtcaggagt tggagatcag cctggccgac atggcgaaac cccatgtcta ctaaaaatac 123720
aaaaactagc caggcatggt ggcacatgcc tgtaatccca gctacttggg aggctgaagc 123780
aggagaatca cttgaaccca ggaggcagag gctgagtgag ccaagatcgt gccaatgcac 123840
tccagcttgg gtgagggagt gagactccgt ctcaaaaaaa aaaaaaaaga aagaaaaaga 123900
aaagaaagtg atcctactgg aaccatgctt actcccctcc ccacctcaca ctgtgtagaa 123960
attagtgctg tcggccaggc gcggtggctc atgcctgtaa tcgcagcact ttgggaggcc 124020
aaggcaggcg gatcacgagg tcaggagatc aagaccatcc tggctaacac agtgaaaccc 124080
tgtctctact aaaaatacaa aaaattagcc gggcatggtg gcaggcacct gtagtcccaa 124140
ctacttggga ggctgaggca ggagaatggc atgaacctgg gaggcggagc ttgcagtgag 124200
ccaagatcgc gccactgcat accagcctag gtgacagagt gagactcagc aaaaaaagaa 124260
agaaagaaag aaagaaatca gtgctgtcta tacttctttc tgcagtgatg gaaatattct 124320
gtatctgtgc tgtccagtat agtagccact agctacatgt ggcacttgaa acatggctgg 124380
tacagttgag gaagagtggc tgccatatcg gacgacacag ctatagattc tgtcacccca 124440
ccccgagagt ccagagcggg gacttctgcc ttaggcccta ttcagggctg atttttactt 124500
gaacccttac tgtgggaaga gaaggccatg agaagttcag tctagaatgt gactccttat 124560
tttctggctc ccttggacac tttgtgggat ttagtctccc tgtggaaagt attccacaag 124620
tggtgccact accccagctg tgagagcagc tgggagctgc ttttgtcatc tttccctgga 124680
aagtcctgtg ggctgtctct tcctcatgcc ttgtcccatg cttgggcatg gtgtcaagcg 124740
tcaggaggga gaaagggtcc ttatttattt atttagagag ggacccttct tctgttccca 124800
ggctggagtg cagtggtgcg atctcggctc actgcaacct ccgcctcctg ggttcaagtg 124860
attctcctgc ctcagcctcc tgagtagctg agattacagg cacatgccaa catgcccggc 124920
taattttttt tttttttttt tttttttttt tttttttttt tttgagatgg agttgtactc 124980
tcattgccca ggctggaatg taatggcaca atctcggctc actgcaacct ccacctcctg 125040
gattcaagca attctcctgt ctcagcttcc caagtagctg ggattacagg tgcccgccac 125100
catgctcaac taatttttgt attttttttt tagtagagac gaggtttcac catgttggtc 125160
agactggtct caaactcctg acctcaggtg atccacctgc ctcggcctcc caaagtgcta 125220
ggattacagg catgagccac cacgcccggc ctgaaagggt tcttatttag tgtgcatttt 125280
gacattcaat ttaattccaa ggtcttgtgg ggtcatggtt tacaggatgt tgatatagaa 125340
aagacttcac ttaatgggcc gggcgcagtg gctcatgcct gtaatcccag cactttggga 125400
ggccgaggca ggcagatcag gaggtcagga gattgagacc atcctggcta acacagtgaa 125460
accccatctc tactgaaaat acaaaaaatt agctgggcgt ggtggcaggc acctgtagtc 125520
ccagccactc ggttggctga ggcaggagaa tggcatgaac ccgggaggcg gagcttgcag 125580
tgagcagaga ccatgccact gcactccagc ctgggcgaca gagcaagact ctgtctcaag 125640
aaaaaaaaaa aaaaacagac tttacttact ggaagccaac caatgtatat ttagagtaat 125700
ttttcctggg ctgagctgtc atttactttt gcagtatctc aagaagaaga gtttacagtg 125760
taaatatttg atgcacactt tgattatata gatgaagcaa actattttca agagctttgc 125820
aaggacttac ttgtatccaa acaccattct aaaaggagtc ttacctactt ctaaaggctg 125880
gtctctactt ggaaccactt gcttggccct ggttcaagtc ctgctgcaaa cctggaagtc 125940
ctgtcattgt cttcttccct ccagagcagt ggcacccaat ctaatttttg ctgtgcccca 126000
gcagcccctg gcactttgcc ctgtagactg cagacctcat gtaatgtatg ttaagtccac 126060
agaaccacag aagatgatgg caagatgctc ttgtgtgtgt tgtgttctag gaggtggcca 126120
ggtggaagta aaatctgaga agcttgactt caaggacaga gtccagtcga agattgggtc 126180
cctggacaat atcacccacg tccctggcgg aggaaataaa aaggtaaagg gggtagggtg 126240
ggttggatgc tgcccttggg tatatgggca ttaatcaagt tgagtggaca aaggctggtc 126300
cagttcccag aggaggaaaa cagaggcttc tgtgttgact ggctggatgt gggccctcag 126360
cagcatccag tgggtctcca ctgcctgtct caatcacctg gagctttagc acgtttcaca 126420
cctgggcccc aacctggaga ggctgaccaa tgggtctcag gggcagctcg gttgctggag 126480
tttttgtttt tatttatttt tatgtattta aggcagggtc tctgtattag tccattctca 126540
cactgctaat aaagacatac ccaagactgg gtaatttata aaggaaagag gtttaatgga 126600
ctcacagttc cacatggctg gggaggcctc aaaatcatgg cggaaggcaa aggagaagca 126660
aaggcatttc ttacatggcg acaggcaaga gagcgtgtgc aggggaactc ccatttataa 126720
aaccatcaga cctcatgaga tttattcact atcatgagaa cagcatggga aagacccgcc 126780
cccatgattc agttacctcc cactgggtcc ctcccatgac acatggaatt atgggagcta 126840
caattcaaga tgagatttgg gtggggacac agccaaacca tatcagtctc cctctgtcat 126900
ccaggctgga gtgcactggc atgatctcgg ctcactgcag cctctacctc cctgggtcag 126960
gtgatcttcc cacctcagcc tcccaggtag ctggaactac aggtacctgc cactatgcct 127020
ggctaaatat tttgtatttc ctgtggagac gaggttttgc cacgttgccc aggctggtct 127080
tgaactcctg aggtcaagca atatgcccac ctcggcctcc caaggtgctg ggattacagg 127140
tgtgagccac agtgctcggc ctaagtcact gcagttttta aagctcccag gtgattcttc 127200
agtgcagtca aaagtgagaa ctggctgggt gcggtggctc atgcctgtaa tcccagcacc 127260
ttgggaggcg aaggtgggca gatggcttga ggtcaggagt tcaagaccag cctggccaac 127320
atggtaaaac cccatctcta ctaaaaatac aaaagttagc tgggtgtggt ggtgcgtgcc 127380
tgtaatccca gctacttggg aggctgaggc atgagaattg cttgaaccca ggggacagag 127440
gttgtagtga gccgagatcg tgccactgca ctccagcctg ggcaacagag tgagattcca 127500
tctcacaaaa aaaaaaaaaa gcgagaacca ctgtcctagg ccctgatgtt tgcaggcaac 127560
taaaaaagga agtggacatc cccagtcagc tgtggcgcac caagaacaag tcatgggaac 127620
ataacctaat tttctaaatg ggttactagg cacttagagc aaaacaatga tgccgaaatc 127680
ctgatttcag caaagcctct gcctgcctgt cttggaagta tccacatgag gctgctgggg 127740
ccttggtgtc cccagcagtt tctagtctct aggtcttgct gtgggtgtct gtgcagtgag 127800
ggtgtgtgtg gcgctgggtg agctctgtct aggcctggca caggatgcgg tctggtagct 127860
gctgcttctc ttctgcagaa gcgcagccaa gcaccctctg gggtttcagg cccacaccca 127920
gcctgaagtt ctgggagtgg ctcactttcc aaccttcagg gtctcccagc agctgactgg 127980
ggagtggtgg agggaaaagg gattgtatta gtccgttttc acgccgctga tgaagacata 128040
cccgatactg ggcagtctaa aagatagagg tctgatggac tcacagttcc acgtgactgg 128100
ggaggcctga caatcatggt ggaaggtgaa aggcttgtct cacacggtgg cagacaagag 128160
aaaagagctt gtgcagggga actccccttt ataaaaccat cagatctcgg gagacttatt 128220
cactatcatg agaacagcac gggaaagacc ctcctctatg attcaattac ctcccaccag 128280
gtccctccca caacatgtag gaattgtggg aactacaatt caagatgaca tttgggtggg 128340
gacacagcca aaccatatca gggcgtccca gaaagggtat agggtctgag acccaagtca 128400
gcatgagaaa gtatgcttct catggtggcc cagttgggtg gaagtggcag ccgggccgtc 128460
tttccaccag gccactcaag tagcagctga gagacccctg ccctggccag tccccgccct 128520
cccctcttgc cactgcctct ggttctgaac agatgggcac cctcatcttg tatttgtgat 128580
taatgtctaa caatgtagtt ttgtgagaag ggtttgctga tacagccttg ctgcagatgc 128640
tgcgaactgt ggcctggggc agaccttacc tccagacacg ccctgaggca ggggagggca 128700
ctggcccgta gctggccgag agctctcggg ttgcgcgaca gggatacttt tcagcggctg 128760
ggtcgctatc caaagtgaga aaacgaggag ggaccaggag gctgtccgcc tcaagagatg 128820
tgggggccag gtccagttat ctggggaagc agtaagcttc tctgctgttt ctaaccccag 128880
gcctcccctg gtctaaggca gggcctccca gcctcggggc actttaaaga tatctgggcc 128940
tggccccatc cccacagtct gactgagtgg gtctggatag ggcctgagca ttggtgattt 129000
cctgggtgaa aggaggcccc tcacagtctc tggaagcttc tctgtgttag gaaaagctct 129060
gggcttgact ctgctttgaa agtcaagatc cgcaaatcct ctcagcctca gtttctcctt 129120
cagcaagatg aaatggaaat gctgtaccta cgtcccgggg tggttgtgag acccaaaaaa 129180
gacaatgttc tggaaggttc ctggtgcgtt gcagtcctct aagaacctga gttagagcca 129240
cgctgagtct cagcttcttg gctccttctg tttcaaactc gtccatgtga tagctcagga 129300
agggtaggca gggccctgcc ccctactcag aaaacaccat cctggtcctg gggatccccg 129360
cagcattagt cccctgtttt cccagtgtat tgagaaaaat tgctaacaag cagtggggca 129420
caccaccagc ctcctgggtt cctttcagtt tggggatttt tggacattcc caggaatgtc 129480
ttaaaaaaca cttcaaaaaa cattaacata aatattttta tcaaagcctg tattaaatgg 129540
tctttcaaga aaatacagta acaggtcagg catggtggct catgcctgta accccagcac 129600
tttgggaggc caaggcaggc agatcacctg aaatcaggag ttcaagacca acctggccaa 129660
cacagccaaa tcccatctct acaaaaaata caaaaattag ctgggtgtgg tggcacacac 129720
ctgtagtccc agctacttgg gaggccgagg caggagaatt gcttgatccc ggaggcggag 129780
gttgcagtga gccgagatcg tgccactgca ctccagcgtg ggtgacaagg tgaatctttg 129840
tctcaaaaaa aaaaaaaaaa aaaagataaa atacagtata cagtaataga gaacaatcct 129900
tttttcaaag tagtgacccc aaatgaacaa aatatgcatc tagcttaaat gcgaacctgg 129960
ttttctctac gcccattcaa gcccctgcaa taggggccct tcaccccgca tccatggact 130020
cctaaaatta tatggaaaat ggctgtgtgt gagtgtggat ggacatgtgc acacatattt 130080
ttggctttac cagatgctca aagagcctag gacccaaaaa gggctgagaa tgaccgtgtc 130140
ggccacttca gggtcatcag gaattgctgt gcactgctca cttctccagt gaacactttc 130200
tgcttctgtg tttcctggta tcctttggga ctcctggcta ggtcatgtgt ttctctactt 130260
tcaaaagggc ttcagccagg cacgatggca tgagcctgta gtcccagttg ctctggaggt 130320
taaggtggga agattgcttg agcccaggaa tttgaggcca gcctgggcaa gtagataggt 130380
agatgattga tagatagata gatagataaa tagatggata gataagtcgc tagacagtca 130440
tccatccacc catccacaca taaaaaggcc tttgtcatgt catgttttgt ggcccacctg 130500
ccagtgttgc ccacagttgc tgcccctcca aactcatcag tcactggcaa acaggaggaa 130560
tgtgtggctc atgtctgggc atcagtggct gtgggagaca tccttgatct tctccagctt 130620
ctccttccac attttccttt gcaatctggc aatatctatt aaaataaaat gtgcatgcct 130680
tttgacctaa gagcttcact tctaggaccc acttacacgt gtgtgacatg atgttcatac 130740
gggtttattt atctgaggtt gttcatacac accattgcct gtaatcacta aaggcgggag 130800
cagcctacac atccatccac agaggagtag atgccttttg gtacatccgt ggcgacggaa 130860
tactaagcag cctgtgtatc tatacactca cacgtgtttg tttatgtgtg gaatatctct 130920
ggagggtaca caagaaactt aaaatgatca ctgtctctgg ggagggtacc tgggtgcctg 130980
ggaggcaggt cagggaagga gtgggcacag gtattaccaa ttggaagaca ataaaaacaa 131040
cagctcctgg ccaggcgcag tggctcacgc ctgtaatggc agcactctga gaggctgagg 131100
cgggcagatt gcttgcgtcc aggagttcaa gaccagcctg ggcaacatag caaaaccccg 131160
tttctattaa aaatacaaaa aattagccag gtgtggtggc atgcacctgt aatcccagct 131220
actcgggagg ctgaggtggg agaatcacct gagcctggga ggtcaaggct gcagtgaggt 131280
gagattgtgc caccgcactc tagcctgggc gatagagcaa gaccctgtct caaaaacaaa 131340
caaaaaacag tccctggcac tctgggccag gcctggcagg gcagttggca gggctggtct 131400
ttctctggca cttcatctca ccctccctcc cttcctcttc ttgcagattg aaacccacaa 131460
gctgaccttc cgcgagaacg ccaaagccaa gacagaccac ggggcggaga tcgtgtacaa 131520
gtcgccagtg gtgtctgggg acacgtctcc acggcatctc agcaatgtct cctccaccgg 131580
cagcatcgac atggtagact cgccccagct cgccacgcta gctgacgagg tgtctgcctc 131640
cctggccaag cagggtttgt gatcaggccc ctggggcggt caataattgt ggagaggaga 131700
gaatgagaga gtgtggaaaa aaaaagaata atgacccggc ccccgccctc tgcccccagc 131760
tgctcctcgc agttcggtta attggttaat cacttaacct gcttttgtca ctcggctttg 131820
gctcgggact tcaaaatcag tgatgggagt aagagcaaat ttcatctttc caaattgatg 131880
ggtgggctag taataaaata tttaaaaaaa aacattcaaa aacatggcca catccaacat 131940
ttcctcaggc aattcctttt gattcttttt tcttccccct ccatgtagaa gagggagaag 132000
gagaggctct gaaagctgct tctgggggat ttcaagggac tgggggtgcc aaccacctct 132060
ggccctgttg tgggggtgtc acagaggcag tggcagcaac aaaggatttg aaacttggtg 132120
tgttcgtgga gccacaggca gacgatgtca accttgtgtg agtgtgacgg gggttggggt 132180
ggggcgggag gccacggggg aggccgaggc aggggctggg cagaggggag aggaagcaca 132240
agaagtggga gtgggagagg aagccacgtg ctggagagta gacatccccc tccttgccgc 132300
tgggagagcc aaggcctatg ccacctgcag cgtctgagcg gccgcctgtc cttggtggcc 132360
gggggtgggg gcctgctgtg ggtcagtgtg ccaccctctg cagggcagcc tgtgggagaa 132420
gggacagcgg gtaaaaagag aaggcaagct ggcaggaggg tggcacttcg tggatgacct 132480
ccttagaaaa gactgacctt gatgtcttga gagcgctggc ctcttcctcc ctccctgcag 132540
ggtagggggc ctgagttgag gggcttccct ctgctccaca gaaaccctgt tttattgagt 132600
tctgaaggtt ggaactgctg ccatgatttt ggccactttg cagacctggg actttagggc 132660
taaccagttc tctttgtaag gacttgtgcc tcttgggaga cgtccacccg tttccaagcc 132720
tgggccactg gcatctctgg agtgtgtggg ggtctgggag gcaggtcccg agccccctgt 132780
ccttcccacg gccactgcag tcacccctgt ctgcgccgct gtgctgttgt ctgccgtgag 132840
agcccaatca ctgcctatac ccctcatcac acgtcacaat gtcccgaatt cccagcctca 132900
ccaccccttc tcagtaatga ccctggttgg ttgcaggagg tacctactcc atactgaggg 132960
tgaaattaag ggaaggcaaa gtccaggcac aagagtggga ccccagcctc tcactctcag 133020
ttccactcat ccaactggga ccctcaccac gaatctcatg atctgattcg gttccctgtc 133080
tcctcctccc gtcacagatg tgagccaggg cactgctcag ctgtgaccct aggtgtttct 133140
gccttgttga catggagaga gccctttccc ctgagaaggc ctggcccctt cctgtgctga 133200
gcccacagca gcaggctggg tgtcttggtt gtcagtggtg gcaccaggat ggaagggcaa 133260
ggcacccagg gcaggcccac agtcccgctg tcccccactt gcaccctagc ttgtagctgc 133320
caacctccca gacagcccag cccgctgctc agctccacat gcatagtatc agccctccac 133380
acccgacaaa ggggaacaca cccccttgga aatggttctt ttcccccagt cccagctgga 133440
agccatgctg tctgttctgc tggagcagct gaacatatac atagatgttg ccctgccctc 133500
cccatctgca ccctgttgag ttgtagttgg atttgtctgt ttatgcttgg attcaccaga 133560
gtgactatga tagtgaaaag aaaaaaaaaa aaaaaaaagg acgcatgtat cttgaaatgc 133620
ttgtaaagag gtttctaacc caccctcacg aggtgtctct cacccccaca ctgggactcg 133680
tgtggcctgt gtggtgccac cctgctgggg cctcccaagt tttgaaaggc tttcctcagc 133740
acctgggacc caacagagac cagcttctag cagctaagga ggccgttcag ctgtgacgaa 133800
ggcctgaagc acaggattag gactgaagcg atgatgtccc cttccctact tccccttggg 133860
gctccctgtg tcagggcaca gactaggtct tgtggctggt ctggcttgcg gcgcgaggat 133920
ggttctctct ggtcatagcc cgaagtctca tggcagtccc aaaggaggct tacaactcct 133980
gcatcacaag aaaaaggaag ccactgccag ctggggggat ctgcagctcc cagaagctcc 134040
gtgagcctca gccacccctc agactgggtt cctctccaag ctcgccctct ggaggggcag 134100
cgcagcctcc caccaagggc cctgcgacca cagcagggat tgggatgaat tgcctgtcct 134160
ggatctgctc tagaggccca agctgcctgc ctgaggaagg atgacttgac aagtcaggag 134220
acactgttcc caaagccttg accagagcac ctcagcccgc tgaccttgca caaactccat 134280
ctgctgccat gagaaaaggg aagccgcctt tgcaaaacat tgctgcctaa agaaactcag 134340
cagcctcagg cccaattctg ccacttctgg tttgggtaca gttaaaggca accctgaggg 134400
acttggcagt agaaatccag ggcctcccct ggggctggca gcttcgtgtg cagctagagc 134460
tttacctgaa aggaagtctc tgggcccaga actctccacc aagagcctcc ctgccgttcg 134520
ctgagtccca gcaattctcc taagttgaag ggatctgaga aggagaagga aatgtggggt 134580
agatttggtg gtggttagag atatgccccc ctcattactg ccaacagttt cggctgcatt 134640
tcttcacgca cctcggttcc tcttcctgaa gttcttgtgc cctgctcttc agcaccatgg 134700
gccttcttat acggaaggct ctgggatctc ccccttgtgg gggcaggctc ttggggccag 134760
cctaagatca tggtttaggg tgatcagtgc tggcagataa attgaaaagg cacgctggct 134820
tgtgatctta aatgaggaca atccccccag ggctgggcac tcctcccctc ccctcacttc 134880
tcccacctgc agagccagtg tccttgggtg ggctagatag gatatactgt atgccggctc 134940
cttcaagctg ctgactcact ttatcaatag ttccatttaa attgacttca gtggtgagac 135000
tgtatcctgt ttgctattgc ttgttgtgct atggggggag gggggaggaa tgtgtaagat 135060
agttaacatg ggcaaaggga gatcttgggg tgcagcactt aaactgcctc gtaacccttt 135120
tcatgatttc aaccacattt gctagaggga gggagcagcc acggagttag aggcccttgg 135180
ggtttctctt ttccactgac aggctttccc aggcagctgg ctagttcatt ccctccccag 135240
ccaggtgcag gcgtaggaat atggacatct ggttgctttg gcctgctgcc ctctttcagg 135300
ggtcctaagc ccacaatcat gcctccctaa gaccttggca tccttccctc taagccgttg 135360
gcacctctgt gccacctctc acactggctc cagacacaca gcctgtgctt ttggagctga 135420
gatcactcgc ttcaccctcc tcatctttgt tctccaagta aagccacgag gtcggggcga 135480
gggcagaggt gatcacctgc gtgtcccatc tacagacctg cggcttcata aaacttctga 135540
tttctcttca gctttgaaaa gggttaccct gggcactggc ctagagcctc acctcctaat 135600
agacttagcc ccatgagttt gccatgttga gcaggactat ttctggcact tgcaagtccc 135660
atgatttctt cggtaattct gagggtgggg ggagggacat gaaatcatct tagcttagct 135720
ttctgtctgt gaatgtctat atagtgtatt gtgtgtttta acaaatgatt tacactgact 135780
gttgctgtaa aagtgaattt ggaaataaag ttattactct gattaaataa ggtctccatt 135840
catggattcc aaggacaaga aagtcatata gaatgtctat tttttaagtt ctttcccacg 135900
cacccttaga taatttagct cagaacagga aatgatagta ttaataaaag ctggacatca 135960
ggattaacag ctctctctgg ggccctgaag gtgagagttc tcagacttgc tcatttgcag 136020
ttgcttcttt gtgatgctgg caaaccatcc tagtcccatt caaagggcaa tacaaagcct 136080
tgtggctgac ctcacgatgc agcactcagt ttgcaagacc ggcaccagtg tatgcaaacc 136140
tgagaaggtt ggggatgagg atatgggatc tttcatccct ggaaatttag tccagaggcc 136200
tggggctgga gcagaacacc aagccaatca gcttaatgaa tggcttagat tcctgctagg 136260
tttgcagagc tgccttcttt cctttggtac cttattatag attgaggagt atttctgcta 136320
aaccaagata gggataacca gatagcatct tcatagcaat gccacaaagg aaaacaaaaa 136380
caaaacagta atccatcata ttattcctta gtaactatgc caaggtcatg atactgaatc 136440
cttagattgt ttcaaaatac tacttttctt tgctcttcct gatgtgtttg ccaccgcagg 136500
cagatgttta agtaaaacag attttaactg cagctacaaa agcagcaaca ggccagcaaa 136560
agagaagtgc tatctcagag agcatggctt tcagagccac aagagacagc ctcactggct 136620
gtttcagctt gactgccatg caaagaagag agcagaggga gaaccagccc cacccactta 136680
ttcatcttgt acaaaaaaaa agcacctacc agcctaggct acatagtgag acactatctc 136740
cacaaaaaac ccacgaaaac tagctgggta tggtggcaca tgcctacagt cccagctact 136800
ggtaaggctg tggtgggagg atctcttgag gccaggaagg agatccaggc tgcagtgagc 136860
caagattgca ccactgcact ccagtctgga caatcgagca agatcccatc tcaaacaata 136920
aaaaaaaaaa gcgtgtaacc tcctcagaag aaagatgtta taatctcagg cagcaggcaa 136980
gaaccaatcc aggctctaag c 137001
<210> 5
<211> 594
<212> DNA
<213> Homo sapiens
<220>
<221> CDS
<222> (375)..(377)
<400> 5
cacgaaggga ccgcgaaggg cagcgccgag aggaaacgag ccgggagacg ccggacggcc 60
gagcggcagg gcgctcgcgc gcgcccacta gtggccggag gagaaggctc ccgcggaggc 120
cgcgctgccc gccccctccc ctggggaggc tcgcgttccc gctgctcgcg cctgcgccgc 180
ccgccggcct caggaacgcg ccctcttcgc cggcgcgcgc cctcgcagtc accgccaccc 240
accagctccg gcaccaacag cagcgccgct gccaccgccc accttctgcc gccgccacca 300
cagccacctt ctcctcctcc gctgtcctct cccgtcctcg cctctgtcga ctatcaggtg 360
aactttgaac cagg atg gctgagcccc gccaggagtt cgaagtgatg gaagatcacg 417
Met
1
ctgggacgta cgggtttggg ggacaggaaa gatcaagggg gctacaccat gcaccaagac 477
caagagggtg acacggacgc tggcctgaaa gctgaagaag caggcattgg agacaccccc 537
agcctggaag acgaagctgc tggtcacgtg acccaagctc gcatggtcag taaaagc 594
<210> 6
<211> 5631
<212> DNA
<213> Homo sapiens
<220>
<221> CDS
<222> (323)..(1468)
<400> 6
ggacggccga gcggcagggc gctcgcgcgc gcccactagt ggccggagga gaaggctccc 60
gcggaggccg cgctgcccgc cccctcccct ggggaggctc gcgttcccgc tgctcgcgcc 120
tgcgccgccc gccggcctca ggaacgcgcc ctcttcgccg gcgcgcgccc tcgcagtcac 180
cgccacccac cagctccggc accaacagca gcgccgctgc caccgcccac cttctgccgc 240
cgccaccaca gccaccttct cctcctccgc tgtcctctcc cgtcctcgcc tctgtcgact 300
atcaggtgaa ctttgaacca gg atg gct gag ccc cgc cag gag ttc gaa gtg 352
Met Ala Glu Pro Arg Gln Glu Phe Glu Val
1 5 10
atg gaa gat cac gct ggg acg tac ggg ttg ggg gac agg aaa gat cag 400
Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln
15 20 25
ggg ggc tac acc atg cac caa gac caa gag ggt gac acg gac gct ggc 448
Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly
30 35 40
ctg aaa gaa tct ccc ctg cag acc ccc act gag gac gga tct gag gaa 496
Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu
45 50 55
ccg ggc tct gaa acc tct gat gct aag agc act cca aca gcg gaa gct 544
Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala
60 65 70
gaa gaa gca ggc att gga gac acc ccc agc ctg gaa gac gaa gct gct 592
Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala
75 80 85 90
ggt cac gtg acc caa gct cgc atg gtc agt aaa agc aaa gac ggg act 640
Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr
95 100 105
gga agc gat gac aaa aaa gcc aag ggg gct gat ggt aaa acg aag atc 688
Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile
110 115 120
gcc aca ccg cgg gga gca gcc cct cca ggc cag aag ggc cag gcc aac 736
Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn
125 130 135
gcc acc agg att cca gca aaa acc ccg ccc gct cca aag aca cca ccc 784
Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro
140 145 150
agc tct ggt gaa cct cca aaa tca ggg gat cgc agc ggc tac agc agc 832
Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser
155 160 165 170
ccc ggc tcc cca ggc act ccc ggc agc cgc tcc cgc acc ccg tcc ctt 880
Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu
175 180 185
cca acc cca ccc acc cgg gag ccc aag aag gtg gca gtg gtc cgt act 928
Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr
190 195 200
cca ccc aag tcg ccg tct tcc gcc aag agc cgc ctg cag aca gcc ccc 976
Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro
205 210 215
gtg ccc atg cca gac ctg aag aat gtc aag tcc aag atc ggc tcc act 1024
Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr
220 225 230
gag aac ctg aag cac cag ccg gga ggc ggg aag gtg caa ata gtc tac 1072
Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr
235 240 245 250
aaa cca gtt gac ctg agc aag gtg acc tcc aag tgt ggc tca tta ggc 1120
Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly
255 260 265
aac atc cat cat aaa cca gga ggt ggc cag gtg gaa gta aaa tct gag 1168
Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu
270 275 280
aag ctt gac ttc aag gac aga gtc cag tcg aag att ggg tcc ctg gac 1216
Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp
285 290 295
aat atc acc cac gtc cct ggc gga gga aat aaa aag att gaa acc cac 1264
Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His
300 305 310
aag ctg acc ttc cgc gag aac gcc aaa gcc aag aca gac cac ggg gcg 1312
Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala
315 320 325 330
gag atc gtg tac aag tcg cca gtg gtg tct ggg gac acg tct cca cgg 1360
Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg
335 340 345
cat ctc agc aat gtc tcc tcc acc ggc agc atc gac atg gta gac tcg 1408
His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser
350 355 360
ccc cag ctc gcc acg cta gct gac gag gtg tct gcc tcc ctg gcc aag 1456
Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys
365 370 375
cag ggt ttg tga tcaggcccct ggggcggtca ataattgtgg agaggagaga 1508
Gln Gly Leu
380
atgagagagt gtggaaaaaa aaagaataat gacccggccc ccgccctctg cccccagctg 1568
ctcctcgcag ttcggttaat tggttaatca cttaacctgc ttttgtcact cggctttggc 1628
tcgggacttc aaaatcagtg atgggagtaa gagcaaattt catctttcca aattgatggg 1688
tgggctagta ataaaatatt taaaaaaaaa cattcaaaaa catggccaca tccaacattt 1748
cctcaggcaa ttccttttga ttcttttttc ttccccctcc atgtagaaga gggagaagga 1808
gaggctctga aagctgcttc tgggggattt caagggactg ggggtgccaa ccacctctgg 1868
ccctgttgtg ggggtgtcac agaggcagtg gcagcaacaa aggatttgaa acttggtgtg 1928
ttcgtggagc cacaggcaga cgatgtcaac cttgtgtgag tgtgacgggg gttggggtgg 1988
ggcgggaggc cacgggggag gccgaggcag gggctgggca gaggggagag gaagcacaag 2048
aagtgggagt gggagaggaa gccacgtgct ggagagtaga catccccctc cttgccgctg 2108
ggagagccaa ggcctatgcc acctgcagcg tctgagcggc cgcctgtcct tggtggccgg 2168
gggtgggggc ctgctgtggg tcagtgtgcc accctctgca gggcagcctg tgggagaagg 2228
gacagcgggt aaaaagagaa ggcaagctgg caggagggtg gcacttcgtg gatgacctcc 2288
ttagaaaaga ctgaccttga tgtcttgaga gcgctggcct cttcctccct ccctgcaggg 2348
tagggggcct gagttgaggg gcttccctct gctccacaga aaccctgttt tattgagttc 2408
tgaaggttgg aactgctgcc atgattttgg ccactttgca gacctgggac tttagggcta 2468
accagttctc tttgtaagga cttgtgcctc ttgggagacg tccacccgtt tccaagcctg 2528
ggccactggc atctctggag tgtgtggggg tctgggaggc aggtcccgag ccccctgtcc 2588
ttcccacggc cactgcagtc accccgtctg cgccgctgtg ctgttgtctg ccgtgagagc 2648
ccaatcactg cctatacccc tcatcacacg tcacaatgtc ccgaattccc agcctcacca 2708
ccccttctca gtaatgaccc tggttggttg caggaggtac ctactccata ctgagggtga 2768
aattaaggga aggcaaagtc caggcacaag agtgggaccc cagcctctca ctctcagttc 2828
cactcatcca actgggaccc tcaccacgaa tctcatgatc tgattcggtt ccctgtctcc 2888
tcctcccgtc acagatgtga gccagggcac tgctcagctg tgaccctagg tgtttctgcc 2948
ttgttgacat ggagagagcc ctttcccctg agaaggcctg gccccttcct gtgctgagcc 3008
cacagcagca ggctgggtgt cttggttgtc agtggtggca ccaggatgga agggcaaggc 3068
acccagggca ggcccacagt cccgctgtcc cccacttgca ccctagcttg tagctgccaa 3128
cctcccagac agcccagccc gctgctcagc tccacatgca tagtatcagc cctccacacc 3188
cgacaaaggg gaacacaccc ccttggaaat ggttcttttc ccccagtccc agctggaagc 3248
catgctgtct gttctgctgg agcagctgaa catatacata gatgttgccc tgccctcccc 3308
atctgcaccc tgttgagttg tagttggatt tgtctgttta tgcttggatt caccagagtg 3368
actatgatag tgaaaagaaa aaaaaaaaaa aaaaaggacg catgtatctt gaaatgcttg 3428
taaagaggtt tctaacccac cctcacgagg tgtctctcac ccccacactg ggactcgtgt 3488
ggcctgtgtg gtgccaccct gctggggcct cccaagtttt gaaaggcttt cctcagcacc 3548
tgggacccaa cagagaccag cttctagcag ctaaggaggc cgttcagctg tgacgaaggc 3608
ctgaagcaca ggattaggac tgaagcgatg atgtcccctt ccctacttcc ccttggggct 3668
ccctgtgtca gggcacagac taggtcttgt ggctggtctg gcttgcggcg cgaggatggt 3728
tctctctggt catagcccga agtctcatgg cagtcccaaa ggaggcttac aactcctgca 3788
tcacaagaaa aaggaagcca ctgccagctg gggggatctg cagctcccag aagctccgtg 3848
agcctcagcc acccctcaga ctgggttcct ctccaagctc gccctctgga ggggcagcgc 3908
agcctcccac caagggccct gcgaccacag cagggattgg gatgaattgc ctgtcctgga 3968
tctgctctag aggcccaagc tgcctgcctg aggaaggatg acttgacaag tcaggagaca 4028
ctgttcccaa agccttgacc agagcacctc agcccgctga ccttgcacaa actccatctg 4088
ctgccatgag aaaagggaag ccgcctttgc aaaacattgc tgcctaaaga aactcagcag 4148
cctcaggccc aattctgcca cttctggttt gggtacagtt aaaggcaacc ctgagggact 4208
tggcagtaga aatccagggc ctcccctggg gctggcagct tcgtgtgcag ctagagcttt 4268
acctgaaagg aagtctctgg gcccagaact ctccaccaag agcctccctg ccgttcgctg 4328
agtcccagca attctcctaa gttgaaggga tctgagaagg agaaggaaat gtggggtaga 4388
tttggtggtg gttagagata tgcccccctc attactgcca acagtttcgg ctgcatttct 4448
tcacgcacct cggttcctct tcctgaagtt cttgtgccct gctcttcagc accatgggcc 4508
ttcttatacg gaaggctctg ggatctcccc cttgtggggc aggctcttgg ggccagccta 4568
agatcatggt ttagggtgat cagtgctggc agataaattg aaaaggcacg ctggcttgtg 4628
atcttaaatg aggacaatcc ccccagggct gggcactcct cccctcccct cacttctccc 4688
acctgcagag ccagtgtcct tgggtgggct agataggata tactgtatgc cggctccttc 4748
aagctgctga ctcactttat caatagttcc atttaaattg acttcagtgg tgagactgta 4808
tcctgtttgc tattgcttgt tgtgctatgg ggggaggggg gaggaatgtg taagatagtt 4868
aacatgggca aagggagatc ttggggtgca gcacttaaac tgcctcgtaa cccttttcat 4928
gatttcaacc acatttgcta gagggaggga gcagccacgg agttagaggc ccttggggtt 4988
tctcttttcc actgacaggc tttcccaggc agctggctag ttcattccct ccccagccag 5048
gtgcaggcgt aggaatatgg acatctggtt gctttggcct gctgccctct ttcaggggtc 5108
ctaagcccac aatcatgcct ccctaagacc ttggcatcct tccctctaag ccgttggcac 5168
ctctgtgcca cctctcacac tggctccaga cacacagcct gtgcttttgg agctgagatc 5228
actcgcttca ccctcctcat ctttgttctc caagtaaagc cacgaggtcg gggcgagggc 5288
agaggtgatc acctgcgtgt cccatctaca gacctgcagc ttcataaaac ttctgatttc 5348
tcttcagctt tgaaaagggt taccctgggc actggcctag agcctcacct cctaatagac 5408
ttagccccat gagtttgcca tgttgagcag gactatttct ggcacttgca agtcccatga 5468
tttcttcggt aattctgagg gtggggggag ggacatgaaa tcatcttagc ttagctttct 5528
gtctgtgaat gtctatatag tgtattgtgt gttttaacaa atgatttaca ctgactgttg 5588
ctgtaaaagt gaatttggaa ataaagttat tactctgatt aaa 5631
<210> 7
<211> 6762
<212> DNA
<213> Homo sapiens
<220>
<221> CDS
<222> (323)..(2599)
<400> 7
ggacggccga gcggcagggc gctcgcgcgc gcccactagt ggccggagga gaaggctccc 60
gcggaggccg cgctgcccgc cccctcccct ggggaggctc gcgttcccgc tgctcgcgcc 120
tgcgccgccc gccggcctca ggaacgcgcc ctcttcgccg gcgcgcgccc tcgcagtcac 180
cgccacccac cagctccggc accaacagca gcgccgctgc caccgcccac cttctgccgc 240
cgccaccaca gccaccttct cctcctccgc tgtcctctcc cgtcctcgcc tctgtcgact 300
atcaggtgaa ctttgaacca gg atg gct gag ccc cgc cag gag ttc gaa gtg 352
Met Ala Glu Pro Arg Gln Glu Phe Glu Val
1 5 10
atg gaa gat cac gct ggg acg tac ggg ttg ggg gac agg aaa gat cag 400
Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln
15 20 25
ggg ggc tac acc atg cac caa gac caa gag ggt gac acg gac gct ggc 448
Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly
30 35 40
ctg aaa gaa tct ccc ctg cag acc ccc act gag gac gga tct gag gaa 496
Leu Lys Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu
45 50 55
ccg ggc tct gaa acc tct gat gct aag agc act cca aca gcg gaa gat 544
Pro Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp
60 65 70
gtg aca gca ccc tta gtg gat gag gga gct ccc ggc aag cag gct gcc 592
Val Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala
75 80 85 90
gcg cag ccc cac acg gag atc cca gaa gga acc aca gct gaa gaa gca 640
Ala Gln Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala
95 100 105
ggc att gga gac acc ccc agc ctg gaa gac gaa gct gct ggt cac gtg 688
Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val
110 115 120
acc caa gag cct gaa agt ggt aag gtg gtc cag gaa ggc ttc ctc cga 736
Thr Gln Glu Pro Glu Ser Gly Lys Val Val Gln Glu Gly Phe Leu Arg
125 130 135
gag cca ggc ccc cca ggt ctg agc cac cag ctc atg tcc ggc atg cct 784
Glu Pro Gly Pro Pro Gly Leu Ser His Gln Leu Met Ser Gly Met Pro
140 145 150
ggg gct ccc ctc ctg cct gag ggc ccc aga gag gcc aca cgc caa cct 832
Gly Ala Pro Leu Leu Pro Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro
155 160 165 170
tcg ggg aca gga cct gag gac aca gag ggc ggc cgc cac gcc cct gag 880
Ser Gly Thr Gly Pro Glu Asp Thr Glu Gly Gly Arg His Ala Pro Glu
175 180 185
ctg ctc aag cac cag ctt cta gga gac ctg cac cag gag ggg ccg ccg 928
Leu Leu Lys His Gln Leu Leu Gly Asp Leu His Gln Glu Gly Pro Pro
190 195 200
ctg aag ggg gca ggg ggc aaa gag agg ccg ggg agc aag gag gag gtg 976
Leu Lys Gly Ala Gly Gly Lys Glu Arg Pro Gly Ser Lys Glu Glu Val
205 210 215
gat gaa gac cgc gac gtc gat gag tcc tcc ccc caa gac tcc cct ccc 1024
Asp Glu Asp Arg Asp Val Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro
220 225 230
tcc aag gcc tcc cca gcc caa gat ggg cgg cct ccc cag aca gcc gcc 1072
Ser Lys Ala Ser Pro Ala Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala
235 240 245 250
aga gaa gcc acc agc atc cca ggc ttc cca gcg gag ggt gcc atc ccc 1120
Arg Glu Ala Thr Ser Ile Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro
255 260 265
ctc cct gtg gat ttc ctc tcc aaa gtt tcc aca gag atc cca gcc tca 1168
Leu Pro Val Asp Phe Leu Ser Lys Val Ser Thr Glu Ile Pro Ala Ser
270 275 280
gag ccc gac ggg ccc agt gta ggg cgg gcc aaa ggg cag gat gcc ccc 1216
Glu Pro Asp Gly Pro Ser Val Gly Arg Ala Lys Gly Gln Asp Ala Pro
285 290 295
ctg gag ttc acg ttt cac gtg gaa atc aca ccc aac gtg cag aag gag 1264
Leu Glu Phe Thr Phe His Val Glu Ile Thr Pro Asn Val Gln Lys Glu
300 305 310
cag gcg cac tcg gag gag cat ttg gga agg gct gca ttt cca ggg gcc 1312
Gln Ala His Ser Glu Glu His Leu Gly Arg Ala Ala Phe Pro Gly Ala
315 320 325 330
cct gga gag ggg cca gag gcc cgg ggc ccc tct ttg gga gag gac aca 1360
Pro Gly Glu Gly Pro Glu Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr
335 340 345
aaa gag gct gac ctt cca gag ccc tct gaa aag cag cct gct gct gct 1408
Lys Glu Ala Asp Leu Pro Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala
350 355 360
ccg cgg ggg aag ccc gtc agc cgg gtc cct caa ctc aaa gct cgc atg 1456
Pro Arg Gly Lys Pro Val Ser Arg Val Pro Gln Leu Lys Ala Arg Met
365 370 375
gtc agt aaa agc aaa gac ggg act gga agc gat gac aaa aaa gcc aag 1504
Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys
380 385 390
aca tcc aca cgt tcc tct gct aaa acc ttg aaa aat agg cct tgc ctt 1552
Thr Ser Thr Arg Ser Ser Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu
395 400 405 410
agc ccc aaa cac ccc act cct ggt agc tca gac cct ctg atc caa ccc 1600
Ser Pro Lys His Pro Thr Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro
415 420 425
tcc agc cct gct gtg tgc cca gag cca cct tcc tct cct aaa tac gtc 1648
Ser Ser Pro Ala Val Cys Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val
430 435 440
tct tct gtc act tcc cga act ggc agt tct gga gca aag gag atg aaa 1696
Ser Ser Val Thr Ser Arg Thr Gly Ser Ser Gly Ala Lys Glu Met Lys
445 450 455
ctc aag ggg gct gat ggt aaa acg aag atc gcc aca ccg cgg gga gca 1744
Leu Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala
460 465 470
gcc cct cca ggc cag aag ggc cag gcc aac gcc acc agg att cca gca 1792
Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala
475 480 485 490
aaa acc ccg ccc gct cca aag aca cca ccc agc tct ggt gaa cct cca 1840
Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro
495 500 505
aaa tca ggg gat cgc agc ggc tac agc agc ccc ggc tcc cca ggc act 1888
Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr
510 515 520
ccc ggc agc cgc tcc cgc acc ccg tcc ctt cca acc cca ccc acc cgg 1936
Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg
525 530 535
gag ccc aag aag gtg gca gtg gtc cgt act cca ccc aag tcg ccg tct 1984
Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser
540 545 550
tcc gcc aag agc cgc ctg cag aca gcc ccc gtg ccc atg cca gac ctg 2032
Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu
555 560 565 570
aag aat gtc aag tcc aag atc ggc tcc act gag aac ctg aag cac cag 2080
Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln
575 580 585
ccg gga ggc ggg aag gtg cag ata att aat aag aag ctg gat ctt agc 2128
Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser
590 595 600
aac gtc cag tcc aag tgt ggc tca aag gat aat atc aaa cac gtc ccg 2176
Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro
605 610 615
gga ggc ggc agt gtg caa ata gtc tac aaa cca gtt gac ctg agc aag 2224
Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys
620 625 630
gtg acc tcc aag tgt ggc tca tta ggc aac atc cat cat aaa cca gga 2272
Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly
635 640 645 650
ggt ggc cag gtg gaa gta aaa tct gag aag ctt gac ttc aag gac aga 2320
Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg
655 660 665
gtc cag tcg aag att ggg tcc ctg gac aat atc acc cac gtc cct ggc 2368
Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly
670 675 680
gga gga aat aaa aag att gaa acc cac aag ctg acc ttc cgc gag aac 2416
Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn
685 690 695
gcc aaa gcc aag aca gac cac ggg gcg gag atc gtg tac aag tcg cca 2464
Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro
700 705 710
gtg gtg tct ggg gac acg tct cca cgg cat ctc agc aat gtc tcc tcc 2512
Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser
715 720 725 730
acc ggc agc atc gac atg gta gac tcg ccc cag ctc gcc acg cta gct 2560
Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala
735 740 745
gac gag gtg tct gcc tcc ctg gcc aag cag ggt ttg tga tcaggcccct 2609
Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu
750 755
ggggcggtca ataattgtgg agaggagaga atgagagagt gtggaaaaaa aaagaataat 2669
gacccggccc ccgccctctg cccccagctg ctcctcgcag ttcggttaat tggttaatca 2729
cttaacctgc ttttgtcact cggctttggc tcgggacttc aaaatcagtg atgggagtaa 2789
gagcaaattt catctttcca aattgatggg tgggctagta ataaaatatt taaaaaaaaa 2849
cattcaaaaa catggccaca tccaacattt cctcaggcaa ttccttttga ttcttttttc 2909
ttccccctcc atgtagaaga gggagaagga gaggctctga aagctgcttc tgggggattt 2969
caagggactg ggggtgccaa ccacctctgg ccctgttgtg ggggtgtcac agaggcagtg 3029
gcagcaacaa aggatttgaa acttggtgtg ttcgtggagc cacaggcaga cgatgtcaac 3089
cttgtgtgag tgtgacgggg gttggggtgg ggcgggaggc cacgggggag gccgaggcag 3149
gggctgggca gaggggagag gaagcacaag aagtgggagt gggagaggaa gccacgtgct 3209
ggagagtaga catccccctc cttgccgctg ggagagccaa ggcctatgcc acctgcagcg 3269
tctgagcggc cgcctgtcct tggtggccgg gggtgggggc ctgctgtggg tcagtgtgcc 3329
accctctgca gggcagcctg tgggagaagg gacagcgggt aaaaagagaa ggcaagctgg 3389
caggagggtg gcacttcgtg gatgacctcc ttagaaaaga ctgaccttga tgtcttgaga 3449
gcgctggcct cttcctccct ccctgcaggg tagggggcct gagttgaggg gcttccctct 3509
gctccacaga aaccctgttt tattgagttc tgaaggttgg aactgctgcc atgattttgg 3569
ccactttgca gacctgggac tttagggcta accagttctc tttgtaagga cttgtgcctc 3629
ttgggagacg tccacccgtt tccaagcctg ggccactggc atctctggag tgtgtggggg 3689
tctgggaggc aggtcccgag ccccctgtcc ttcccacggc cactgcagtc accccgtctg 3749
cgccgctgtg ctgttgtctg ccgtgagagc ccaatcactg cctatacccc tcatcacacg 3809
tcacaatgtc ccgaattccc agcctcacca ccccttctca gtaatgaccc tggttggttg 3869
caggaggtac ctactccata ctgagggtga aattaaggga aggcaaagtc caggcacaag 3929
agtgggaccc cagcctctca ctctcagttc cactcatcca actgggaccc tcaccacgaa 3989
tctcatgatc tgattcggtt ccctgtctcc tcctcccgtc acagatgtga gccagggcac 4049
tgctcagctg tgaccctagg tgtttctgcc ttgttgacat ggagagagcc ctttcccctg 4109
agaaggcctg gccccttcct gtgctgagcc cacagcagca ggctgggtgt cttggttgtc 4169
agtggtggca ccaggatgga agggcaaggc acccagggca ggcccacagt cccgctgtcc 4229
cccacttgca ccctagcttg tagctgccaa cctcccagac agcccagccc gctgctcagc 4289
tccacatgca tagtatcagc cctccacacc cgacaaaggg gaacacaccc ccttggaaat 4349
ggttcttttc ccccagtccc agctggaagc catgctgtct gttctgctgg agcagctgaa 4409
catatacata gatgttgccc tgccctcccc atctgcaccc tgttgagttg tagttggatt 4469
tgtctgttta tgcttggatt caccagagtg actatgatag tgaaaagaaa aaaaaaaaaa 4529
aaaaaggacg catgtatctt gaaatgcttg taaagaggtt tctaacccac cctcacgagg 4589
tgtctctcac ccccacactg ggactcgtgt ggcctgtgtg gtgccaccct gctggggcct 4649
cccaagtttt gaaaggcttt cctcagcacc tgggacccaa cagagaccag cttctagcag 4709
ctaaggaggc cgttcagctg tgacgaaggc ctgaagcaca ggattaggac tgaagcgatg 4769
atgtcccctt ccctacttcc ccttggggct ccctgtgtca gggcacagac taggtcttgt 4829
ggctggtctg gcttgcggcg cgaggatggt tctctctggt catagcccga agtctcatgg 4889
cagtcccaaa ggaggcttac aactcctgca tcacaagaaa aaggaagcca ctgccagctg 4949
gggggatctg cagctcccag aagctccgtg agcctcagcc acccctcaga ctgggttcct 5009
ctccaagctc gccctctgga ggggcagcgc agcctcccac caagggccct gcgaccacag 5069
cagggattgg gatgaattgc ctgtcctgga tctgctctag aggcccaagc tgcctgcctg 5129
aggaaggatg acttgacaag tcaggagaca ctgttcccaa agccttgacc agagcacctc 5189
agcccgctga ccttgcacaa actccatctg ctgccatgag aaaagggaag ccgcctttgc 5249
aaaacattgc tgcctaaaga aactcagcag cctcaggccc aattctgcca cttctggttt 5309
gggtacagtt aaaggcaacc ctgagggact tggcagtaga aatccagggc ctcccctggg 5369
gctggcagct tcgtgtgcag ctagagcttt acctgaaagg aagtctctgg gcccagaact 5429
ctccaccaag agcctccctg ccgttcgctg agtcccagca attctcctaa gttgaaggga 5489
tctgagaagg agaaggaaat gtggggtaga tttggtggtg gttagagata tgcccccctc 5549
attactgcca acagtttcgg ctgcatttct tcacgcacct cggttcctct tcctgaagtt 5609
cttgtgccct gctcttcagc accatgggcc ttcttatacg gaaggctctg ggatctcccc 5669
cttgtggggc aggctcttgg ggccagccta agatcatggt ttagggtgat cagtgctggc 5729
agataaattg aaaaggcacg ctggcttgtg atcttaaatg aggacaatcc ccccagggct 5789
gggcactcct cccctcccct cacttctccc acctgcagag ccagtgtcct tgggtgggct 5849
agataggata tactgtatgc cggctccttc aagctgctga ctcactttat caatagttcc 5909
atttaaattg acttcagtgg tgagactgta tcctgtttgc tattgcttgt tgtgctatgg 5969
ggggaggggg gaggaatgtg taagatagtt aacatgggca aagggagatc ttggggtgca 6029
gcacttaaac tgcctcgtaa cccttttcat gatttcaacc acatttgcta gagggaggga 6089
gcagccacgg agttagaggc ccttggggtt tctcttttcc actgacaggc tttcccaggc 6149
agctggctag ttcattccct ccccagccag gtgcaggcgt aggaatatgg acatctggtt 6209
gctttggcct gctgccctct ttcaggggtc ctaagcccac aatcatgcct ccctaagacc 6269
ttggcatcct tccctctaag ccgttggcac ctctgtgcca cctctcacac tggctccaga 6329
cacacagcct gtgcttttgg agctgagatc actcgcttca ccctcctcat ctttgttctc 6389
caagtaaagc cacgaggtcg gggcgagggc agaggtgatc acctgcgtgt cccatctaca 6449
gacctgcagc ttcataaaac ttctgatttc tcttcagctt tgaaaagggt taccctgggc 6509
actggcctag agcctcacct cctaatagac ttagccccat gagtttgcca tgttgagcag 6569
gactatttct ggcacttgca agtcccatga tttcttcggt aattctgagg gtggggggag 6629
ggacatgaaa tcatcttagc ttagctttct gtctgtgaat gtctatatag tgtattgtgt 6689
gttttaacaa atgatttaca ctgactgttg ctgtaaaagt gaatttggaa ataaagttat 6749
tactctgatt aaa 6762
<210> 8
<400> 8
000
<210> 9
<400> 9
000
<210> 10
<211> 21
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 10
aagattgggt ccctggacaa t 21
<210> 11
<211> 26
<212> DNA
<213> Artificial sequence
<220>
<223> Primer
<400> 11
agcttgtggg tttcaatctt tttatt 26
<210> 12
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Probe
<400> 12
cacccacgtc cctggcgga 19
<210> 13
<400> 13
000
<210> 14
<400> 14
000
<210> 15
<400> 15
000
<210> 16
<400> 16
000
<210> 17
<400> 17
000
<210> 18
<400> 18
000
<210> 19
<400> 19
000
<210> 20
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 20
ttgtagacta tttgcacact 20
<210> 21
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 21
cacaggcaga tgcgaaccct 20
<210> 22
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 22
tggtggagac aagacattct 20
<210> 23
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 23
ccatccccta atagttagca 20
<210> 24
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 24
catgaggctt gggatctgaa 20
<210> 25
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 25
gtgatcttcc atcacttcga 20
<210> 26
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 26
gtccactaac ctttcaggcc 20
<210> 27
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 27
agcatcagag gtttcagagc 20
<210> 28
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 28
gttggagtgc tcttagcatc 20
<210> 29
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 29
ggcagcctgc ttgccgggag 20
<210> 30
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 30
gaggatttcc ttggagagag 20
<210> 31
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 31
gttcactgac cttgggtcac 20
<210> 32
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 32
atgatttcta gaggtcatgc 20
<210> 33
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 33
agaggaaatc cacagggagg 20
<210> 34
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 34
ttcagagggc tctggaaggt 20
<210> 35
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 35
acaccatgag ggcacccgtc 20
<210> 36
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 36
accatgcgag ctgataaaat 20
<210> 37
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 37
aaggttttag cagaggaacg 20
<210> 38
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 38
aggaaggtgg ctctgggcac 20
<210> 39
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 39
ccagagctgg gtggtgtctt 20
<210> 40
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 40
ggtggagtac ggaccactgc 20
<210> 41
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 41
aagacggcga cttgggtgga 20
<210> 42
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 42
tggtgcttca ggttctcagt 20
<210> 43
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 43
ttatctgcac ctttggtagc 20
<210> 44
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 44
tcttattaat tatctgcacc 20
<210> 45
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 45
agatccagct tcttattaat 20
<210> 46
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 46
cgttgctaag atccagcttc 20
<210> 47
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 47
gagccacact tggactggac 20
<210> 48
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 48
ggtggcgcag gctaagcata 20
<210> 49
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 49
gagccacact tggaggtcac 20
<210> 50
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 50
acagggctac ctggtttatg 20
<210> 51
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 51
attttacttc cacctggcca 20
<210> 52
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 52
ggacccaatc ttcgactgga 20
<210> 53
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 53
gtgggtttca atctgcaaga 20
<210> 54
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 54
gtcagcttgt gggtttcaat 20
<210> 55
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 55
gatcacaaac cctgcttggc 20
<210> 56
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 56
tgattttgaa gtcccgagcc 20
<210> 57
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 57
atcactgatt ttgaagtccc 20
<210> 58
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 58
cagaagcagc tttcagagcc 20
<210> 59
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 59
aaatcctttg ttgctgccac 20
<210> 60
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 60
cccacaggct gccctgcaga 20
<210> 61
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 61
ggaggtcatc cacgaagtgc 20
<210> 62
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 62
ggaagcccct caactcaggc 20
<210> 63
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 63
ggtctgcaaa gtggccaaaa 20
<210> 64
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 64
tggttagccc taaagtccca 20
<210> 65
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 65
acaaagagaa ctggttagcc 20
<210> 66
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 66
aagaggcaca agtccttaca 20
<210> 67
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 67
cagagatgcc agtggcccag 20
<210> 68
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 68
ggaaccgaat cagatcatga 20
<210> 69
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 69
tggagggctg atactatgca 20
<210> 70
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 70
aaaagaacca tttccaaggg 20
<210> 71
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 71
atccaactac aactcaacag 20
<210> 72
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 72
atcatagtca ctctggtgaa 20
<210> 73
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 73
gccacacgag tcccagtgtg 20
<210> 74
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 74
aaaacttggg aggccccagc 20
<210> 75
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 75
gatccaggac aggcaattca 20
<210> 76
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 76
tcctcaggca ggcagcttgg 20
<210> 77
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 77
ttctcatggc agcagatgga 20
<210> 78
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 78
ttaggcagca atgttttgca 20
<210> 79
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 79
agagttctgg gcccagagac 20
<210> 80
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 80
aggaagagga accgaggtgc 20
<210> 81
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 81
tcttaggctg gccccaagag 20
<210> 82
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 82
tcaatttatc tgccagcact 20
<210> 83
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 83
tcctcattta agatcacaag 20
<210> 84
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 84
atggaactat tgataaagtg 20
<210> 85
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 85
caccactgaa gtcaatttaa 20
<210> 86
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 86
agtttaagtg ctgcacccca 20
<210> 87
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 87
gaaatcatga aaagggttac 20
<210> 88
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 88
ctctagcaaa tgtggttgaa 20
<210> 89
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 89
agccagctgc ctgggaaagc 20
<210> 90
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 90
tagagggaag gatgccaagg 20
<210> 91
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 91
gtgtgtctgg agccagtgtg 20
<210> 92
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 92
gaaatcatgg gacttgcaag 20
<210> 93
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 93
aaagctaagc taagatgatt 20
<210> 94
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 94
ttacagcaac agtcagtgta 20
<210> 95
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 95
ttgtagacta tttgcacctt 20
<210> 96
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 96
tcttcagctt tcaggccagc 20
<210> 97
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 97
agaagtttta tgaagccgca 20
<210> 98
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 98
cacttcgaac tcctggcggg 20
<210> 99
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 99
atcacttcga actcctggcg 20
<210> 100
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 100
ccatcacttc gaactcctgg 20
<210> 101
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 101
ttccatcact tcgaactcct 20
<210> 102
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 102
tcttccatca cttcgaactc 20
<210> 103
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 103
gatcttccat cacttcgaac 20
<210> 104
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 104
cctgtccccc aacccgtacg 20
<210> 105
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 105
ttcctgtccc ccaacccgta 20
<210> 106
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 106
ctttcctgtc ccccaacccg 20
<210> 107
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 107
atctttcctg tcccccaacc 20
<210> 108
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 108
tgatctttcc tgtcccccaa 20
<210> 109
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 109
cctgatcttt cctgtccccc 20
<210> 110
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 110
cccctgatct ttcctgtccc 20
<210> 111
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 111
cccccctgat ctttcctgtc 20
<210> 112
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 112
agcccccctg atctttcctg 20
<210> 113
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 113
gtagcccccc tgatctttcc 20
<210> 114
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 114
gtgtagcccc cctgatcttt 20
<210> 115
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 115
tggtgtagcc cccctgatct 20
<210> 116
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 116
catggtgtag cccccctgat 20
<210> 117
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 117
tgcatggtgt agcccccctg 20
<210> 118
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 118
ggtgcatggt gtagcccccc 20
<210> 119
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 119
ttggtgcatg gtgtagcccc 20
<210> 120
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 120
tcttggtgca tggtgtagcc 20
<210> 121
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 121
ggtcttggtg catggtgtag 20
<210> 122
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 122
ctcttggtct tggtgcatgg 20
<210> 123
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 123
cgtccgtgtc accctcttgg 20
<210> 124
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 124
gcttttactg accatgcgag 20
<210> 125
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 125
ttgcttttac tgaccatgcg 20
<210> 126
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 126
ctttgctttt actgaccatg 20
<210> 127
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 127
gtctttgctt ttactgacca 20
<210> 128
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 128
ccgtctttgc ttttactgac 20
<210> 129
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 129
tcccgtcttt gcttttactg 20
<210> 130
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 130
agtcccgtct ttgcttttac 20
<210> 131
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 131
ccagtcccgt ctttgctttt 20
<210> 132
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 132
gcttccagtc ccgtctttgc 20
<210> 133
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 133
tcgcttccag tcccgtcttt 20
<210> 134
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 134
catcgcttcc agtcccgtct 20
<210> 135
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 135
gtcatcgctt ccagtcccgt 20
<210> 136
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 136
ttgtcatcgc ttccagtccc 20
<210> 137
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 137
ttttgtcatc gcttccagtc 20
<210> 138
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 138
ggcccttctg gcctggaggg 20
<210> 139
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 139
ctggcccttc tggcctggag 20
<210> 140
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 140
gcctggccct tctggcctgg 20
<210> 141
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 141
tggcctggcc cttctggcct 20
<210> 142
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 142
gttggcctgg cccttctggc 20
<210> 143
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 143
ttttgctgga atcctggtgg 20
<210> 144
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 144
gtttttgctg gaatcctggt 20
<210> 145
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 145
gggtttttgc tggaatcctg 20
<210> 146
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 146
ggtgtctttg gagcgggcgg 20
<210> 147
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 147
gtggtgtctt tggagcgggc 20
<210> 148
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 148
gggtggtgtc tttggagcgg 20
<210> 149
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 149
ctgggtggtg tctttggagc 20
<210> 150
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 150
agctgggtgg tgtctttgga 20
<210> 151
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 151
agagctgggt ggtgtctttg 20
<210> 152
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 152
atcccctgat tttggaggtt 20
<210> 153
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 153
cgatcccctg attttggagg 20
<210> 154
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 154
tgcgatcccc tgattttgga 20
<210> 155
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 155
gctgcgatcc cctgattttg 20
<210> 156
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 156
ccgctgcgat cccctgattt 20
<210> 157
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 157
agccgctgcg atcccctgat 20
<210> 158
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 158
gtagccgctg cgatcccctg 20
<210> 159
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 159
cggctgccgg gagtgcctgg 20
<210> 160
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 160
agcggctgcc gggagtgcct 20
<210> 161
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 161
ggagcggctg ccgggagtgc 20
<210> 162
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 162
cgacttgggt ggagtacgga 20
<210> 163
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 163
ggcgacttgg gtggagtacg 20
<210> 164
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 164
acggcgactt gggtggagta 20
<210> 165
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 165
agacggcgac ttgggtggag 20
<210> 166
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 166
gaagacggcg acttgggtgg 20
<210> 167
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 167
cggaagacgg cgacttgggt 20
<210> 168
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 168
ggcggaagac ggcgacttgg 20
<210> 169
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 169
ttggcggaag acggcgactt 20
<210> 170
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 170
tcttggcgga agacggcgac 20
<210> 171
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 171
gctcttggcg gaagacggcg 20
<210> 172
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 172
cggctcttgg cggaagacgg 20
<210> 173
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 173
ggcggctctt ggcggaagac 20
<210> 174
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 174
gggagattct ttcaggccag 20
<210> 175
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 175
gagctttgag ttgagggacc 20
<210> 176
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 176
gaccatgcga gctttgagtt 20
<210> 177
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 177
tactgaccat gcgagctttg 20
<210> 178
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 178
atagtcgaca gaggcgagga 20
<210> 179
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 179
catcctggtt caaagttcac 20
<210> 180
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 180
ctcagccatc ctggttcaaa 20
<210> 181
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 181
gctcagccat cctggttcaa 20
<210> 182
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 182
ggttcctcag atccgtcctc 20
<210> 183
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 183
tgttggagtg ctcttagcat 20
<210> 184
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 184
tgcgcggcag cctgcttgcc 20
<210> 185
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 185
accaccttac cactttcagg 20
<210> 186
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 186
gggagcccca ggcatgccgg 20
<210> 187
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 187
ttggagagga aatccacagg 20
<210> 188
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 188
gaaactttgg agaggaaatc 20
<210> 189
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 189
ttttactgac catgcgagct 20
<210> 190
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 190
aaggcaaggc ctatttttca 20
<210> 191
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 191
tggatcagag ggtctgagct 20
<210> 192
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 192
gtggctctgg gcacacagca 20
<210> 193
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 193
ggagtacgga ccactgccac 20
<210> 194
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 194
caggcggctc ttggcggaag 20
<210> 195
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 195
tgcaggcggc tcttggcgga 20
<210> 196
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 196
tctgcaggcg gctcttggcg 20
<210> 197
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 197
tggagccgat cttggacttg 20
<210> 198
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 198
agtggagccg atcttggact 20
<210> 199
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 199
ctcagtggag ccgatcttgg 20
<210> 200
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 200
ttctcagtgg agccgatctt 20
<210> 201
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 201
tcccggctgg tgcttcaggt 20
<210> 202
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 202
tttcggactt ggcagaggca 20
<210> 203
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 203
gagtgacatg cgccaccctg 20
<210> 204
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 204
ctttcgatga gtgacatgcg 20
<210> 205
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 205
aaaaggatga gtgacacgcc 20
<210> 206
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 206
gtgaaggtac tcacactgcc 20
<210> 207
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 207
tgtgaaggta ctcacactgc 20
<210> 208
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 208
ctatgcagtg tctcgcaagt 20
<210> 209
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 209
ggatttattc tatgcagtgt 20
<210> 210
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 210
aggatttatt ctatgcagtg 20
<210> 211
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 211
tgagagccca agaaggattt 20
<210> 212
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 212
cagatcctga gagcccaaga 20
<210> 213
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 213
agccagatcc tgagagccca 20
<210> 214
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 214
ggacccagaa atgctgggac 20
<210> 215
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 215
aaatgtgttg tcgaaattct 20
<210> 216
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 216
agtcagggtg gaaaaatgtg 20
<210> 217
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 217
agcacatcct agtcagggtg 20
<210> 218
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 218
gccatgagga gcacatccta 20
<210> 219
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 219
gtggttccca gctgccatga 20
<210> 220
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 220
acagtggttc ccagctgcca 20
<210> 221
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 221
cccaggccct tattggacag 20
<210> 222
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 222
cttgctcagg tcaactggtt 20
<210> 223
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 223
ggatgttgcc taatgagcca 20
<210> 224
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 224
gtccagggac ccaatcttcg 20
<210> 225
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 225
ttgtccaggg acccaatctt 20
<210> 226
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 226
aaggtcagct tgtgggtttc 20
<210> 227
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 227
ctccgccccg tggtctgtct 20
<210> 228
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 228
atctccgccc cgtggtctgt 20
<210> 229
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 229
cgatctccgc cccgtggtct 20
<210> 230
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 230
cacgatctcc gccccgtggt 20
<210> 231
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 231
tacacgatct ccgccccgtg 20
<210> 232
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 232
tgtacacgat ctccgccccg 20
<210> 233
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 233
cttgtacacg atctccgccc 20
<210> 234
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 234
gacttgtaca cgatctccgc 20
<210> 235
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 235
gcgacttgta cacgatctcc 20
<210> 236
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 236
tggcgacttg tacacgatct 20
<210> 237
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 237
actggcgact tgtacacgat 20
<210> 238
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 238
ccactggcga cttgtacacg 20
<210> 239
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 239
cagacaccac tggcgacttg 20
<210> 240
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 240
gctgccggtg gaggagacat 20
<210> 241
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 241
tgctgccggt ggaggagaca 20
<210> 242
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 242
tgtcgatgct gccggtggag 20
<210> 243
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 243
atgtcgatgc tgccggtgga 20
<210> 244
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 244
gagtctacca tgtcgatgct 20
<210> 245
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 245
ccagggaggc agacacctcg 20
<210> 246
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 246
ctgcttggcc agggaggcag 20
<210> 247
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 247
tgatcacaaa ccctgcttgg 20
<210> 248
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 248
ccgaactgcg aggagcagct 20
<210> 249
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 249
tgcttacaca ccacacacac 20
<210> 250
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 250
atgcttacac accacacaca 20
<210> 251
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 251
catgcttaca caccacacac 20
<210> 252
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 252
tacagatata tgattggatg 20
<210> 253
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 253
gtacagatat atgattggat 20
<210> 254
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 254
tgtacagata tatgattgga 20
<210> 255
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 255
atgtacagat atatgattgg 20
<210> 256
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 256
tatgtacaga tatatgattg 20
<210> 257
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 257
ttatgtacag atatatgatt 20
<210> 258
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 258
attatgtaca gatatatgat 20
<210> 259
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 259
gattatgtac agatatatga 20
<210> 260
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 260
ggattatgta cagatatatg 20
<210> 261
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 261
tggattatgt acagatatat 20
<210> 262
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 262
atggattatg tacagatata 20
<210> 263
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 263
aatggattat gtacagatat 20
<210> 264
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 264
gaatggatta tgtacagata 20
<210> 265
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 265
agaatggatt atgtacagat 20
<210> 266
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 266
aagaatggat tatgtacaga 20
<210> 267
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 267
gaagaatgga ttatgtacag 20
<210> 268
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 268
ggaagaatgg attatgtaca 20
<210> 269
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 269
gggaagaatg gattatgtac 20
<210> 270
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 270
agggaagaat ggattatgta 20
<210> 271
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 271
gagggaagaa tggattatgt 20
<210> 272
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 272
cgagggaaga atggattatg 20
<210> 273
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 273
ccgagggaag aatggattat 20
<210> 274
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 274
accgagggaa gaatggatta 20
<210> 275
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 275
aaccgaggga agaatggatt 20
<210> 276
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 276
gaaccgaggg aagaatggat 20
<210> 277
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 277
tgaaccgagg gaagaatgga 20
<210> 278
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 278
atgaaccgag ggaagaatgg 20
<210> 279
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 279
gatgaaccga gggaagaatg 20
<210> 280
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 280
ggatgaaccg agggaagaat 20
<210> 281
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 281
tggatgaacc gagggaagaa 20
<210> 282
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 282
atggatgaac cgagggaaga 20
<210> 283
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 283
gatggatgaa ccgagggaag 20
<210> 284
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 284
ggatggatga accgagggaa 20
<210> 285
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 285
tggatggatg aaccgaggga 20
<210> 286
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 286
atggatggat gaaccgaggg 20
<210> 287
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 287
gatggatgga tgaaccgagg 20
<210> 288
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 288
ggatggatgg atgaaccgag 20
<210> 289
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 289
aaggatgaag gaagggatgg 20
<210> 290
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 290
gaaggatgaa ggaagggatg 20
<210> 291
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 291
ggaaggatga aggaagggat 20
<210> 292
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 292
taggaaggat gaaggaaggg 20
<210> 293
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 293
ataggaagga tgaaggaagg 20
<210> 294
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 294
gataggaagg atgaaggaag 20
<210> 295
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 295
tgataggaag gatgaaggaa 20
<210> 296
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 296
atgataggaa ggatgaagga 20
<210> 297
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 297
gatgatagga aggatgaagg 20
<210> 298
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 298
ggatgatagg aaggatgaag 20
<210> 299
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 299
tggatgatag gaaggatgaa 20
<210> 300
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 300
atggatgata ggaaggatga 20
<210> 301
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 301
gatggatgat aggaaggatg 20
<210> 302
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 302
ggatggatga taggaaggat 20
<210> 303
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 303
tggatggatg ataggaagga 20
<210> 304
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 304
ttggatggat gataggaagg 20
<210> 305
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 305
attggatgga tgataggaag 20
<210> 306
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 306
gattggatgg atgataggaa 20
<210> 307
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 307
tgattggatg gatgatagga 20
<210> 308
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 308
atgattggat ggatgatagg 20
<210> 309
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 309
tatgattgga tggatgatag 20
<210> 310
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 310
agatatgggt ggatggatgg 20
<210> 311
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 311
aagatatggg tggatggatg 20
<210> 312
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 312
gaagatatgg gtggatggat 20
<210> 313
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 313
acacaccttc atttactgtc 20
<210> 314
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 314
aacacacctt catttactgt 20
<210> 315
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 315
aaacacacct tcatttactg 20
<210> 316
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 316
caaacacacc ttcatttact 20
<210> 317
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 317
tcaaacacac cttcatttac 20
<210> 318
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 318
tttcaaacac accttcattt 20
<210> 319
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 319
ttttcaaaca caccttcatt 20
<210> 320
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 320
gttttcaaac acaccttcat 20
<210> 321
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 321
ggttttcaaa cacaccttca 20
<210> 322
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 322
tggttttcaa acacaccttc 20
<210> 323
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 323
gaaaacagag aaaagcacaa 20
<210> 324
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 324
agaagtgata tcatatccta 20
<210> 325
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 325
aagaagtgat atcatatcct 20
<210> 326
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 326
cttcagcttt caggccagcg 20
<210> 327
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 327
ccatgcgagc ttgggtcacg 20
<210> 328
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 328
cagccccctt ggcttttttg 20
<210> 329
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 329
ttgcaccttc ccgcctcccg 20
<210> 330
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 330
tgccgctcgg ccgtccggcg 20
<210> 331
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 331
gcccggcgca cgaagcccca 20
<210> 332
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 332
agaaagaaat ccgccccgag 20
<210> 333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 333
ataatggaat acttattgca 20
<210> 334
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 334
gcaggagcat ggcacctgga 20
<210> 335
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 335
actcgctgac atggtgtttg 20
<210> 336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 336
gatgactcca caatgtaaac 20
<210> 337
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 337
cctataggat tatccaggaa 20
<210> 338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 338
catttctcat cagccatcga 20
<210> 339
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 339
accaaagact tcagatcagc 20
<210> 340
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 340
agcttctggg agctgcagat 20
<210> 341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 341
agaggaaccc agtctgaggg 20
<210> 342
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 342
aggctgcgct gcccctccag 20
<210> 343
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 343
aatccctgct gtggtcgcag 20
<210> 344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 344
tctagagcag atccaggaca 20
<210> 345
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 345
aagtcatcct tcctcaggca 20
<210> 346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 346
caaggctttg ggaacagtgt 20
<210> 347
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 347
gtcaaggctt tgggaacagt 20
<210> 348
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 348
ttgtgcaagg tcagcgggct 20
<210> 349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 349
cggcttccct tttctcatgg 20
<210> 350
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 350
tgagtttctt taggcagcaa 20
<210> 351
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 351
aaccagaagt ggcagaattg 20
<210> 352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 352
caagtccctc agggttgcct 20
<210> 353
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 353
cgaagctgcc agccccaggg 20
<210> 354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 354
agacttcctt tcaggtaaag 20
<210> 355
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 355
agggaggctc ttggtggaga 20
<210> 356
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 356
acttaggaga attgctggga 20
<210> 357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 357
cccacatttc cttctccttc 20
<210> 358
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 358
actgttggca gtaatgaggg 20
<210> 359
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 359
ggaagaggaa ccgaggtgcg 20
<210> 360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 360
catggtgctg aagagcaggg 20
<210> 361
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 361
gggagatccc agagccttcc 20
<210> 362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 362
cttaggctgg ccccaagagc 20
<210> 363
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 363
tatctgccag cactgatcac 20
<210> 364
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 364
tttaagatca caagccagcg 20
<210> 365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 365
gaggagtgcc cagccctggg 20
<210> 366
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 366
ctggctctgc aggtgggaga 20
<210> 367
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 367
tacagtatat cctatctagc 20
<210> 368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 368
ataaagtgag tcagcagctt 20
<210> 369
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 369
tcaccactga agtcaattta 20
<210> 370
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 370
agcacaacaa gcaatagcaa 20
<210> 371
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 371
actatcttac acattcctcc 20
<210> 372
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 372
gctgcacccc aagatctccc 20
<210> 373
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 373
aaatcatgaa aagggttacg 20
<210> 374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 374
gtggctgctc cctccctcta 20
<210> 375
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 375
cccaagggcc tctaactccg 20
<210> 376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 376
tggaaaagag aaaccccaag 20
<210> 377
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 377
tgaactagcc agctgcctgg 20
<210> 378
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 378
tattcctacg cctgcacctg 20
<210> 379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 379
agagggcagc aggccaaagc 20
<210> 380
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 380
ttagggaggc atgattgtgg 20
<210> 381
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 381
ccaacggctt agagggaagg 20
<210> 382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 382
tgccaacggc ttagagggaa 20
<210> 383
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 383
tgtctggagc cagtgtgaga 20
<210> 384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 384
cgagtgatct cagctccaaa 20
<210> 385
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 385
tgatcacctc tgccctcgcc 20
<210> 386
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 386
tgaagctgca ggtctgtaga 20
<210> 387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 387
cttttcaaag ctgaagagaa 20
<210> 388
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 388
aggtgaggct ctaggccagt 20
<210> 389
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 389
caacatggca aactcatggg 20
<210> 390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 390
atgggacttg caagtgccag 20
<210> 391
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 391
cctcccccca ccctcagaat 20
<210> 392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 392
agacagaaag ctaagctaag 20
<210> 393
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 393
ttaaaacaca caatacacta 20
<210> 394
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 394
acttttacag caacagtcag 20
<210> 395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 395
tttaatcaga gtaataactt 20
<210> 396
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 396
tgcccttcgc ggtcccttcg 20
<210> 397
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 397
ctgtccccca aacccgtacg 20
<210> 398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 398
gcttccgctg ttggagtgct 20
<210> 399
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 399
gccctgccgc tcggccgtcc 20
<210> 400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 400
ttctcctccg gccactagtg 20
<210> 401
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 401
gaacgcgagc ctccccaggg 20
<210> 402
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 402
gaggccggcg ggcggcgcag 20
<210> 403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 403
gagggcgcgc gccggcgaag 20
<210> 404
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 404
ttggtgccgg agctggtggg 20
<210> 405
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 405
ggcagaaggt gggcggtggc 20
<210> 406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 406
tgatagtcga cagaggcgag 20
<210> 407
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 407
gtcttggtgc atggtgtagc 20
<210> 408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 408
cctcagatcc gtcctcagtg 20
<210> 409
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 409
tgctcttagc atcagaggtt 20
<210> 410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 410
ctaagggtgc tgtcacatct 20
<210> 411
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 411
cggcagcctg cttgccggga 20
<210> 412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 412
tggttccttc tgggatctcc 20
<210> 413
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 413
ctcggaggaa gccttcctgg 20
<210> 414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 414
tgagctggtg gctcagacct 20
<210> 415
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 415
cctgtccccg aaggttggcg 20
<210> 416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 416
ggtgcttgag cagctcaggg 20
<210> 417
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 417
gcggcccctc ctggtgcagg 20
<210> 418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 418
ccggcctctc tttgccccct 20
<210> 419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 419
cgtcgcggtc ttcatccacc 20
<210> 420
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 420
ggccgcccat cttgggctgg 20
<210> 421
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 421
atgctggtgg cttctctggc 20
<210> 422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 422
atggcaccct ccgctgggaa 20
<210> 423
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 423
gctctgaggc tgggatctct 20
<210> 424
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 424
gccctttggc ccgccctaca 20
<210> 425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 425
cgttgggtgt gatttccacg 20
<210> 426
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 426
aatgctcctc cgagtgcgcc 20
<210> 427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 427
cctctggccc ctctccaggg 20
<210> 428
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 428
cttttgtgtc ctctcccaaa 20
<210> 429
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 429
gctgcttttc agagggctct 20
<210> 430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 430
ggctgacggg cttcccccgc 20
<210> 431
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 431
tttgagttga gggacccggc 20
<210> 432
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 432
tctgagctac caggagtggg 20
<210> 433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 433
gcacacagca gggctggagg 20
<210> 434
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 434
gggaagtgac agaagagacg 20
<210> 435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 435
gtttcatctc ctttgctcca 20
<210> 436
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 436
ccgcggtgtg gcgatcttcg 20
<210> 437
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 437
ggcctggccc ttctggcctg 20
<210> 438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 438
cttctctgga cttgcttagt 20
<210> 439
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 439
ctctcagatc tgggccctgc 20
<210> 440
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 440
cctctctcag atctgggccc 20
<210> 441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 441
tagccgctgc gatcccctga 20
<210> 442
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 442
ccaccttctt gggctcccgg 20
<210> 443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 443
caggtctggc atgggcacgg 20
<210> 444
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 444
caccttcccg cctcccggct 20
<210> 445
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 445
gttgctaaga tccagcttct 20
<210> 446
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 446
gatattatcc tttgagccac 20
<210> 447
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 447
ggtcaccttg ctcaggtcaa 20
<210> 448
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 448
atgatggatg ttgcctaatg 20
<210> 449
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 449
gagattcttt caggccagcg 20
<210> 450
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 450
tttcaggctc ttgggtcacg 20
<210> 451
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 451
gctttgagtt gagggacccg 20
<210> 452
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 452
tatttgcaca ctgccgcctc 20
<210> 453
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 453
agattttact tccacctggc 20
<210> 454
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 454
cgactggact ctgtccttga 20
<210> 455
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 455
tatttcctcc gccagggacg 20
<210> 456
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 456
cgcggaaggt cagcttgtgg 20
<210> 457
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 457
ccgccccgtg gtctgtcttg 20
<210> 458
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 458
ccccagacac cactggcgac 20
<210> 459
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 459
gccggtggag gagacattgc 20
<210> 460
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 460
aattattgac cgccccaggg 20
<210> 461
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 461
tttttccaca ctctctcatt 20
<210> 462
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 462
aactgcgagg agcagctggg 20
<210> 463
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 463
caaaagcagg ttaagtgatt 20
<210> 464
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 464
ctgattttga agtcccgagc 20
<210> 465
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 465
atttgctctt actcccatca 20
<210> 466
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 466
ttggaaagat gaaatttgct 20
<210> 467
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 467
tgttggatgt ggccatgttt 20
<210> 468
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 468
gtcccttgaa atcccccaga 20
<210> 469
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 469
ccacaacagg gccagaggtg 20
<210> 470
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 470
tcctttgttg ctgccactgc 20
<210> 471
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 471
gcctgtggct ccacgaacac 20
<210> 472
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 472
ccccgtcaca ctcacacaag 20
<210> 473
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 473
ggcctccccc gtggcctccc 20
<210> 474
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 474
tgcttcctct cccctctgcc 20
<210> 475
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 475
gatgtctact ctccagcacg 20
<210> 476
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 476
ataggccttg gctctcccag 20
<210> 477
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 477
aggacaggcg gccgctcaga 20
<210> 478
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 478
tgacccacag caggccccca 20
<210> 479
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 479
ctcccacagg ctgccctgca 20
<210> 480
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 480
cagcttgcct tctcttttta 20
<210> 481
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 481
aaggaggtca tccacgaagt 20
<210> 482
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 482
gacatcaagg tcagtctttt 20
<210> 483
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 483
agggaggaag aggccagcgc 20
<210> 484
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 484
agcccctcaa ctcaggcccc 20
<210> 485
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 485
tcaataaaac agggtttctg 20
<210> 486
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 486
caaaatcatg gcagcagttc 20
<210> 487
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 487
gttagcccta aagtcccagg 20
<210> 488
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 488
cccaagaggc acaagtcctt 20
<210> 489
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 489
cagtggccca ggcttggaaa 20
<210> 490
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 490
tgcctcccag acccccacac 20
<210> 491
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 491
agtggccgtg ggaaggacag 20
<210> 492
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 492
acaacagcac agcggcgcag 20
<210> 493
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 493
acggcagaca acagcacagc 20
<210> 494
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 494
gaattcggga cattgtgacg 20
<210> 495
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 495
cagggtcatt actgagaagg 20
<210> 496
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 496
ctcagtatgg agtaggtacc 20
<210> 497
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 497
tgtgcctgga ctttgccttc 20
<210> 498
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 498
ggaactgaga gtgagaggct 20
<210> 499
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 499
gaatcagatc atgagattcg 20
<210> 500
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 500
cacatctgtg acgggaggag 20
<210> 501
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 501
cacctagggt cacagctgag 20
<210> 502
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 502
gaaagggctc tctccatgtc 20
<210> 503
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 503
gtgggctcag cacaggaagg 20
<210> 504
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 504
acccagcctg ctgctgtggg 20
<210> 505
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 505
accactgaca accaagacac 20
<210> 506
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 506
gccctgggtg ccttgccctt 20
<210> 507
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 507
acaagctagg gtgcaagtgg 20
<210> 508
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 508
ggagctgagc agcgggctgg 20
<210> 509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 509
ccctttgtcg ggtgtggagg 20
<210> 510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 510
tggcttccag ctgggactgg 20
<210> 511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 511
atatgttcag ctgctccagc 20
<210> 512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 512
actcaacagg gtgcagatgg 20
<210> 513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 513
gaatccaagc ataaacagac 20
<210> 514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 514
tttttttctt ttcactatca 20
<210> 515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 515
agcatttcaa gatacatgcg 20
<210> 516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 516
cacacgagtc ccagtgtggg 20
<210> 517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 517
ttgggtccca ggtgctgagg 20
<210> 518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 518
acggcctcct tagctgctag 20
<210> 519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 519
taatcctgtg cttcaggcct 20
<210> 520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 520
tgacacaggg agccccaagg 20
<210> 521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 521
agccagacca gccacaagac 20
<210> 522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 522
gctatgacca gagagaacca 20
<210> 523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 523
ggactgccat gagacttcgg 20
<210> 524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 524
taagcctcct ttgggactgc 20
<210> 525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 525
agtggcttcc tttttcttgt 20
<210> 526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 526
ggcaatgcct ggaagaaact 20
<210> 527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 527
cgctggtgag agtgtgactg 20
<210> 528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 528
atccgagggt gagatgataa 20
<210> 529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 529
aataatttct ccaggctcat 20
<210> 530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 530
gctgacttcg atttgttatt 20
<210> 531
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 531
tatcatatgg cacaaattct 20
<210> 532
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 532
ctacctggga ccacacctta 20
<210> 533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 533
gggtggagag cctgatggtc 20
<210> 534
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 534
ctgtgagcat catgaaagcc 20
<210> 535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 535
ttttattatg agggagatca 20
<210> 536
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 536
aatagtagag aaatggaaat 20
<210> 537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 537
taacatgaca gggttaggcc 20
<210> 538
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 538
gcccacacac atgctcatgc 20
<210> 539
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 539
tgtgttcagt tacatgcctt 20
<210> 540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 540
gaccaccatg gtgggctgac 20
<210> 541
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 541
ggcacctctc tgcagacttt 20
<210> 542
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 542
tgcttcacac accacaatgg 20
<210> 543
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 543
aacattgccg agcaccagcc 20
<210> 544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 544
gactcaggaa catgttagct 20
<210> 545
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 545
cacggctcag cagaggagac 20
<210> 546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 546
gctgctatcc ttcctgggcc 20
<210> 547
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 547
ggaaatgaaa gcttcccacg 20
<210> 548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 548
aacagtcaga atacccccaa 20
<210> 549
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 549
tataggtaga atataaaact 20
<210> 550
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 550
tatgaacaaa actgcaggac 20
<210> 551
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 551
agcctccaga gtgacaggtg 20
<210> 552
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 552
ccataagcca ctcctggttg 20
<210> 553
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 553
cagcttggaa gatacaggag 20
<210> 554
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 554
caaacttaag aaaagttgca 20
<210> 555
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 555
tgctggcaaa gaagacagga 20
<210> 556
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 556
ccactgatgg ccgggtgcag 20
<210> 557
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 557
tgggtgtcaa atggctggct 20
<210> 558
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 558
tagaaagcta tttaataaat 20
<210> 559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 559
agccgtacat caatggtaca 20
<210> 560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 560
ggccctacca tggtcgattt 20
<210> 561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 561
atcagtgcca gagacagagg 20
<210> 562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 562
tattattaac gaacaaaaaa 20
<210> 563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 563
agagcaatac tttgtgctta 20
<210> 564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 564
agactcctca aatgtgcgcc 20
<210> 565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 565
gaatgacggc cgcctcctct 20
<210> 566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 566
tatggagggc ttctggcctc 20
<210> 567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 567
gagaaagagc gagtaattag 20
<210> 568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 568
tagctagaaa ctgtgtccct 20
<210> 569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 569
ctgtgagatc atcccctggt 20
<210> 570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 570
cagcgcagtg cagggagtca 20
<210> 571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 571
gggtacacag agaggccact 20
<210> 572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 572
gaacgatgca ctgccttggc 20
<210> 573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 573
caccatatta caccagttgt 20
<210> 574
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 574
ctgaaatgaa tcccctgaac 20
<210> 575
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 575
gtgtccacga atgcccctgg 20
<210> 576
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 576
acggatggtt gctgctgatg 20
<210> 577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 577
gtcccttttg ctcccaaaga 20
<210> 578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 578
cagtctttta ataagtgaaa 20
<210> 579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 579
ttagctaaat tgaggcccgg 20
<210> 580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 580
ggaaaggtat tgcctcctga 20
<210> 581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 581
ggtgactacg cagcctggac 20
<210> 582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 582
ttcagggcaa tccttgaggt 20
<210> 583
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 583
tgctaatgct ttgggaccta 20
<210> 584
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 584
tgggtagaga gcaactgttc 20
<210> 585
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 585
acaccccttc tctgcacatc 20
<210> 586
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 586
ctgctagagt tcgccaacag 20
<210> 587
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 587
tcttattctc taggtgggct 20
<210> 588
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 588
cagtgcaagt gggtatgaag 20
<210> 589
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 589
cagatgcagt gcaagtgggt 20
<210> 590
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 590
gaaaaacttt gtccataatt 20
<210> 591
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 591
taatgaatgt ataacagaaa 20
<210> 592
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 592
aaaaggcaga tactttgtgg 20
<210> 593
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 593
cagaggtgtg aaagtaaaag 20
<210> 594
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 594
cagctaaagc tttgtgaaca 20
<210> 595
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 595
tgcagcccag gtgagccagc 20
<210> 596
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 596
gcctctcctc ccagttcatg 20
<210> 597
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 597
gttttcttat ttttagcatt 20
<210> 598
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 598
ggagggacga gaaacagcag 20
<210> 599
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 599
agcttccagc atgaacatag 20
<210> 600
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 600
gagccctgat atgatagagg 20
<210> 601
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 601
tgtaccatgc ctggcagatg 20
<210> 602
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 602
gttagatgta tgtatgatgg 20
<210> 603
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 603
gcctcctcct agagctcctg 20
<210> 604
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 604
cggcctcgca acaaacccac 20
<210> 605
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 605
tccactgacc tgccccttcc 20
<210> 606
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 606
tttgcaactt gttcctgctt 20
<210> 607
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 607
tcttgggtgc aggcggagca 20
<210> 608
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 608
acccaagatt cccaggagcc 20
<210> 609
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 609
aggccctaaa tgctctgaga 20
<210> 610
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 610
agaagtctct ggaactgacg 20
<210> 611
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 611
tcaccaaacc aatggctggc 20
<210> 612
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 612
ggtgaaatcc tggctaggcc 20
<210> 613
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 613
tgcagattcg gcctgagttt 20
<210> 614
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 614
ccaaacaaga aagactgaga 20
<210> 615
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 615
ccatgtccct ccccccaacc 20
<210> 616
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 616
attagaaaaa aaccactagg 20
<210> 617
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 617
agcttactag agtgctcttg 20
<210> 618
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 618
atttttttct ggttcattca 20
<210> 619
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 619
cgcttaagag agggagcatc 20
<210> 620
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 620
gtggagatac gcagtggtgg 20
<210> 621
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 621
cccaaacctg gctctgtcac 20
<210> 622
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 622
atcaaccagc accatccacg 20
<210> 623
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 623
gggtctgtaa gcctaaagtg 20
<210> 624
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 624
tgggtctgta agcctaaagt 20
<210> 625
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 625
tatactatgt ggcagaatca 20
<210> 626
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 626
cacattccct ctaccccatg 20
<210> 627
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 627
tcatagattt tcttctttgg 20
<210> 628
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 628
ttcaaacaca ccttcattta 20
<210> 629
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 629
ccccagctgg ccgaggccca 20
<210> 630
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 630
gagaagggtc ctgtcccaga 20
<210> 631
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 631
agtaagttga tggagatcat 20
<210> 632
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 632
caccagcccc actccgccac 20
<210> 633
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 633
tgctctgtct ccagagacat 20
<210> 634
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 634
atccaagatc caggccaggc 20
<210> 635
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 635
agagacccag ggtgaccagt 20
<210> 636
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 636
caaatttctc gatccccttc 20
<210> 637
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 637
cctgaggagg gcactcacag 20
<210> 638
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 638
gtggctaccc acggccacag 20
<210> 639
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 639
ctaccaggag cacacacaga 20
<210> 640
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 640
ccctaagcca tggtgggttt 20
<210> 641
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 641
cccttgtccc cacagccaca 20
<210> 642
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 642
gggtcacctg tgagttattt 20
<210> 643
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 643
agctgcctcc agttgtttat 20
<210> 644
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 644
actttagctc catcttctca 20
<210> 645
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 645
ctataatggt cagtggtgta 20
<210> 646
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 646
tgaaggagag gctgtggtga 20
<210> 647
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 647
tgtgacaaca aagttgtcct 20
<210> 648
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 648
ccctgcaatc aacacaggag 20
<210> 649
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 649
tctaacatgc acatatttac 20
<210> 650
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 650
agcactgggt gtttacaaca 20
<210> 651
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 651
acccggtgac ctttcctctc 20
<210> 652
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 652
gccacagcac ggcgcatggg 20
<210> 653
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 653
gcaccgctcc ctctgggaat 20
<210> 654
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 654
aaatcttgct ggaaaggcag 20
<210> 655
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 655
gacccagaca tttgctcagc 20
<210> 656
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 656
gggctcccgc aagtttcaca 20
<210> 657
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 657
gagaggccct gtggacagct 20
<210> 658
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 658
cccactggat gctgctgagg 20
<210> 659
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 659
gtgcctagta acccatttag 20
<210> 660
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 660
cacccacagc aagacctaga 20
<210> 661
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 661
acacagagaa gcttccagag 20
<210> 662
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 662
agctatcaca tggacgagtt 20
<210> 663
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 663
catttaatac aggctttgat 20
<210> 664
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 664
agccactgat gcccagacat 20
<210> 665
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 665
gttttcaaac acaccttc 18
<210> 666
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 666
tcgccaacag acatgtga 18
<210> 667
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 667
tgaaggagcc tgggaagt 18
<210> 668
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 668
agcagagatg tggctggg 18
<210> 669
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 669
gtgaggttga aaagtttc 18
<210> 670
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 670
tggtttctga tggttttt 18
<210> 671
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 671
gttggaactc ctgggatc 18
<210> 672
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 672
tcagcatttt tctcctct 18
<210> 673
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 673
ctggaatggt acgatctc 18
<210> 674
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 674
ccactctggt gcaggacg 18
<210> 675
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 675
cagatgcagt gcaagtgg 18
<210> 676
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 676
gggtttcacc agacctca 18
<210> 677
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 677
ctttgtccat aatttttt 18
<210> 678
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 678
tatagcatga gcatttgt 18
<210> 679
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 679
taatgaatgt ataacaga 18
<210> 680
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 680
tcctcctggc tgccctgt 18
<210> 681
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 681
catcctgcca taccagac 18
<210> 682
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 682
tatccgcctc tcaaagtg 18
<210> 683
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 683
cacatttgca tattttca 18
<210> 684
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 684
tcgggttgcc ccattcaa 18
<210> 685
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 685
aaccaccatt tactcaca 18
<210> 686
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 686
accggcaccc accaggtc 18
<210> 687
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 687
agggacagca tcagcaga 18
<210> 688
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 688
aggcatgtgg caggtgcc 18
<210> 689
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 689
accaacaccg cagcagtt 18
<210> 690
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 690
gttctgagga gtgttggg 18
<210> 691
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 691
actaaccttt caggccag 18
<210> 692
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 692
taaattattt tagagacg 18
<210> 693
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 693
caaggtaaat ttctttct 18
<210> 694
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 694
tcaggcctga tctaagta 18
<210> 695
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 695
tccccaacca tgtggtct 18
<210> 696
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 696
tgccagccac acccatgg 18
<210> 697
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 697
aactccacgg cttccatg 18
<210> 698
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 698
agatagaaat ctgaaacg 18
<210> 699
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 699
gctgggccga gctgcatt 18
<210> 700
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 700
ggattcaaag gagaaaac 18
<210> 701
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 701
attattattt gacatggg 18
<210> 702
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 702
agggtaggca gtgttgtg 18
<210> 703
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 703
ctctctttgt caggaaaa 18
<210> 704
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 704
cctttttttt taggacgg 18
<210> 705
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 705
gagttgactg ggcacggt 18
<210> 706
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 706
tcatctgtga agcggacg 18
<210> 707
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 707
ggcacaatcc atatgagg 18
<210> 708
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 708
gttattttgg aacagttt 18
<210> 709
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 709
ctggacttta tttcattt 18
<210> 710
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 710
cagtatatat agtgcata 18
<210> 711
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 711
caaaacagct ccttgtaa 18
<210> 712
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 712
actttcatct acttttca 18
<210> 713
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 713
ccaatctgtc cccagctt 18
<210> 714
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 714
tccagcatga acatagct 18
<210> 715
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 715
tagagtcagt ttcaggat 18
<210> 716
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 716
ggtggtatca ccaacagc 18
<210> 717
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 717
ttaaggaatg gctctggg 18
<210> 718
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 718
gaacatgaga catcttga 18
<210> 719
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 719
agctgtgccc agttaaaa 18
<210> 720
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 720
tctggtcata tgaggaaa 18
<210> 721
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 721
agtcattatc atgtcacc 18
<210> 722
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 722
gctgagcgaa ttacctaa 18
<210> 723
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 723
cctctgtatg acagaaat 18
<210> 724
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 724
ggtaacatgt aaagcttc 18
<210> 725
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 725
tggattatgt acagatat 18
<210> 726
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 726
atggatgata ggaaggat 18
<210> 727
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 727
gatggaggaa ggaatgat 18
<210> 728
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 728
ctggatggtt acatggat 18
<210> 729
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 729
ataattgatg tataatta 18
<210> 730
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 730
gttctgcccc acctgggc 18
<210> 731
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 731
gcctctcagg gcctccgt 18
<210> 732
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 732
gaaggatggc cacacaga 18
<210> 733
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 733
atgggcttat caatgcat 18
<210> 734
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 734
gaggcccaaa tgatcaca 18
<210> 735
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 735
gctcagggca gacacggt 18
<210> 736
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 736
cttaaccagc tagtggtg 18
<210> 737
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 737
gtcctgtgga gctgaaaa 18
<210> 738
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 738
ggctggaggc atggaggg 18
<210> 739
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 739
tgcctccaga gcacacac 18
<210> 740
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 740
aggatactaa accaagat 18
<210> 741
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 741
cacagatggg aagcaaga 18
<210> 742
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 742
catgaggcaa caatccaa 18
<210> 743
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 743
gccgtaagac ccagctct 18
<210> 744
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 744
gaagaagtac tgagaaag 18
<210> 745
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 745
taagaacctc agcggcaa 18
<210> 746
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 746
tgagggagca ctgagagt 18
<210> 747
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 747
agttcaatga aggacatt 18
<210> 748
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 748
actgttggat gggtccac 18
<210> 749
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 749
ttggtccatt ttgattgg 18
<210> 750
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 750
cggcagccct gtgtaaac 18
<210> 751
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 751
cctttgcttc ttgcgcag 18
<210> 752
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 752
agggccttga ctgcctgg 18
<210> 753
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 753
aaggccctaa atgctctg 18
<210> 754
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 754
cgctcaggtg atcttggg 18
<210> 755
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 755
ctgattgatt ccccatca 18
<210> 756
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 756
ttcttgttgg gcaactgg 18
<210> 757
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 757
gaaatgcact cagaaggg 18
<210> 758
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 758
cctcagtgaa ataactgt 18
<210> 759
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 759
tggctgcaac tttgaatg 18
<210> 760
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 760
ctggagatgg caggctgg 18
<210> 761
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 761
cccgtgggcc ccatgtgg 18
<210> 762
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 762
attgaggaca cctggtgt 18
<210> 763
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 763
aaggtctgca ttgtcagt 18
<210> 764
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 764
ctgctggcct ctctgtac 18
<210> 765
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 765
tcggacacgg tcactgcc 18
<210> 766
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 766
gtgccttgtc atgtgaca 18
<210> 767
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 767
ggaagccatg tggtagcc 18
<210> 768
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 768
cagaggccac tgcctctg 18
<210> 769
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 769
ttaatagtac caaaatca 18
<210> 770
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 770
tacatttcct tcctccca 18
<210> 771
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 771
cggagtcagg cagatggg 18
<210> 772
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 772
gctatgacct agtaggaa 18
<210> 773
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 773
attgtttact agaaacca 18
<210> 774
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 774
gggcagagcc caccccat 18
<210> 775
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 775
aggctggaca aggctagc 18
<210> 776
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 776
catatttgag tttctttt 18
<210> 777
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 777
aatgattaca caaagctg 18
<210> 778
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 778
gaacagtgtc tttccagc 18
<210> 779
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 779
atgtgccttt ctgtgcca 18
<210> 780
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 780
aatgatttct agaggtca 18
<210> 781
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 781
ccatgattcc aggctgct 18
<210> 782
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 782
cagccaggct agtcttgc 18
<210> 783
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 783
aggagaatgt tctttttt 18
<210> 784
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 784
ttactgtact ctgatata 18
<210> 785
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 785
ccttatggga gccctttg 18
<210> 786
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 786
cagagcgcag cagcacct 18
<210> 787
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 787
ctcaccagct ctgcttta 18
<210> 788
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 788
cagctgatca agggcaca 18
<210> 789
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 789
agacctgcca taagactc 18
<210> 790
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 790
ctgactaaaa tgttattt 18
<210> 791
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 791
acaggcatga gttttttt 18
<210> 792
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 792
cccctttttt ttggtttg 18
<210> 793
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 793
tctggagccg ccctgggc 18
<210> 794
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 794
atgacagctc tcctggtc 18
<210> 795
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 795
actctcaact cctctggt 18
<210> 796
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 796
tcctgttgga ggaggcgc 18
<210> 797
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 797
cctttgagtt gagggacc 18
<210> 798
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 798
gcctgagcac gggaggag 18
<210> 799
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 799
gacaccatga gggcaccc 18
<210> 800
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 800
agcacctcct gggaggcg 18
<210> 801
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 801
ggtggcatgt ggaccagg 18
<210> 802
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 802
tgtggctctg aggtctcc 18
<210> 803
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 803
gcctctgtct taactttt 18
<210> 804
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 804
ttagggtaca gtggtgtg 18
<210> 805
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 805
cctctagtag gccagtat 18
<210> 806
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 806
aatcaagtaa gtttggga 18
<210> 807
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 807
caactgggtc tgtaagcc 18
<210> 808
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 808
tagattttct tctttggt 18
<210> 809
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 809
gggcacgaat tctcactg 18
<210> 810
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 810
tccagaatag gagaggct 18
<210> 811
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 811
acactgcagc caggcttg 18
<210> 812
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 812
tgcagtctcc ctaaccca 18
<210> 813
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 813
ctcttttccc ttgaatct 18
<210> 814
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 814
gtcagcttac cttggctt 18
<210> 815
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 815
caactgctct tccctggg 18
<210> 816
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 816
tctgggtgca gtttatgc 18
<210> 817
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 817
agaatttatg ctggaaat 18
<210> 818
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 818
ggccagctct ccaaatcc 18
<210> 819
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 819
ccctagactc tgggcaac 18
<210> 820
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 820
tctaagtaat tcgatatg 18
<210> 821
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 821
aaacagaaac tagggtgg 18
<210> 822
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 822
tcccgctggg atccatgg 18
<210> 823
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 823
tgttgccatt gggcagcc 18
<210> 824
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 824
gaccttctaa ttagtcca 18
<210> 825
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 825
gcgattctct cctgtctc 18
<210> 826
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 826
actcagattt attatttt 18
<210> 827
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 827
aaagtactat ccacttgt 18
<210> 828
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 828
caaatcctgg gttcgaat 18
<210> 829
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 829
aggtctctgc ccatgaaa 18
<210> 830
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 830
agatttctcc cttcaccc 18
<210> 831
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 831
ttaacatgat ggtggttt 18
<210> 832
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 832
cattgtggaa attaaaca 18
<210> 833
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 833
tgtagtcaat attgaact 18
<210> 834
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 834
ttttgagagc aggtctcg 18
<210> 835
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 835
atggcaaaca gtacatgt 18
<210> 836
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 836
aggatttaag tgattttc 18
<210> 837
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 837
tacaaagacc ccttttcc 18
<210> 838
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 838
agctgccagc agtccttg 18
<210> 839
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 839
ctgctgtagg aaatgacc 18
<210> 840
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 840
agctccaacc agctttct 18
<210> 841
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 841
gtcctgatta acagctaa 18
<210> 842
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 842
gtctgtctgc tgccatcc 18
<210> 843
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 843
gtaactgata tggtaaca 18
<210> 844
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 844
agccctcttt gtacagga 18
<210> 845
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 845
ctgttccagt tgatccag 18
<210> 846
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 846
gcagtctttt taaattaa 18
<210> 847
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 847
cctctgctca catagaaa 18
<210> 848
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 848
agtacctgcc ttgttcct 18
<210> 849
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 849
aagcatggta atacaaaa 18
<210> 850
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 850
ttgattaaaa aaaatagc 18
<210> 851
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 851
ttcatccttt ccaagtgt 18
<210> 852
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 852
catgcttaca caccacac 18
<210> 853
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 853
tgcttacaca ccacacac 18
<210> 854
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 854
atatgctgaa cacacaca 18
<210> 855
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 855
ccaccgaggt ctcattgg 18
<210> 856
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 856
gggagacctc cctttcaa 18
<210> 857
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 857
tctctgggtg tagagacg 18
<210> 858
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 858
gcaggctcgg gctccacg 18
<210> 859
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 859
ccttgtcaga tggttgat 18
<210> 860
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 860
tctgcagact tttctcaa 18
<210> 861
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 861
ctggagggag gtgatgtg 18
<210> 862
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 862
gaaagctgct gctgaggg 18
<210> 863
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 863
gggcaaagat aattcgaa 18
<210> 864
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 864
cctcaccctg ggcaagaa 18
<210> 865
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 865
ttgctgctcg ggaggccg 18
<210> 866
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 866
aaatgaaaga tgctggct 18
<210> 867
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 867
cagagaggtc cagctact 18
<210> 868
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 868
agctcactac agcaggca 18
<210> 869
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 869
tatttcttgc aattcttt 18
<210> 870
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 870
ggaggactgt ctctagag 18
<210> 871
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 871
tccggcctgg cgaactga 18
<210> 872
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 872
cctgcaaagc taatttta 18
<210> 873
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 873
gagccccctt taagcctt 18
<210> 874
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 874
gtacaaagac tgtgtacg 18
<210> 875
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 875
gactcaggaa catgttag 18
<210> 876
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 876
tgaggcagca atgctggg 18
<210> 877
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 877
cactgggagg tgtataga 18
<210> 878
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 878
gcgaggtggg tgaaggtt 18
<210> 879
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 879
aaaaactttg gcagtcag 18
<210> 880
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 880
ggtctgccct gcaccagg 18
<210> 881
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 881
ctgagctctc cgagctgc 18
<210> 882
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 882
gtgaggtggt atcattgg 18
<210> 883
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 883
ctagcttgaa ttcctcca 18
<210> 884
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 884
aatctgtgac tcaagaac 18
<210> 885
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 885
gggccgtctc tattaaaa 18
<210> 886
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 886
ggtataattt gtttggac 18
<210> 887
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 887
ctttattgca tataggta 18
<210> 888
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 888
atccagtccc aacattgg 18
<210> 889
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 889
cggtctctct gacttgcc 18
<210> 890
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 890
gagggcattc ctcaaagg 18
<210> 891
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 891
agttctctga ttctcaaa 18
<210> 892
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 892
cccccagtgc ccacaagt 18
<210> 893
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 893
ctaaaagcta aagtgggt 18
<210> 894
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 894
aggacctggc agagctgc 18
<210> 895
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 895
aaatcgaaca cttacata 18
<210> 896
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 896
ttgccatctt ggacaggg 18
<210> 897
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 897
acaccttcat ttactgtc 18
<210> 898
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 898
ttttcaaaca caccttca 18
<210> 899
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 899
ggttttcaaa cacacctt 18
<210> 900
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 900
tggttttcaa acacacct 18
<210> 901
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 901
tacctgatag tcgacaga 18
<210> 902
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 902
gtccctttcc aggccgcc 18
<210> 903
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 903
cgcccattgc ggcaaaag 18
<210> 904
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 904
cactgctcgg gaggtgca 18
<210> 905
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 905
tgttctcagg cacggcgc 18
<210> 906
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 906
gccctgcgct ccgagcgc 18
<210> 907
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 907
aaaaaagatg gcacctcg 18
<210> 908
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 908
acaaagcaaa gagccccc 18
<210> 909
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 909
tcacgcccgt tccatgcg 18
<210> 910
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 910
ccggatgggt agccagcg 18
<210> 911
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 911
ccctctccgg acacctgt 18
<210> 912
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 912
aaatacaccc agggccgc 18
<210> 913
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 913
gatagaatta accagaaa 18
<210> 914
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 914
agcctcgcag tacccagg 18
<210> 915
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 915
tcgcgagatg gcaatacg 18
<210> 916
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 916
ttcctccatt aacagcgc 18
<210> 917
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 917
cccgcctgct gggaatgg 18
<210> 918
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 918
agaactcaaa ttggtcct 18
<210> 919
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 919
tataagcagc ttatacag 18
<210> 920
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 920
ccaagccagg ttattgct 18
<210> 921
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 921
tctaacaatt tatgggca 18
<210> 922
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 922
aacaaatgga ctgtaaca 18
<210> 923
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 923
ttcaaggagg gagtaagg 18
<210> 924
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 924
aggaaagtgg tggtggag 18
<210> 925
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 925
tgcagcccag ctggtgag 18
<210> 926
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 926
tccttgtagg atgtttaa 18
<210> 927
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 927
acctgctaca tagcggaa 18
<210> 928
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 928
ttatagatca tatctggg 18
<210> 929
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 929
aaacagagca ccaatgta 18
<210> 930
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 930
acctcagaga cttgacct 18
<210> 931
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 931
cccaggaagt gagaaaag 18
<210> 932
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 932
cagttgggag ccatctgg 18
<210> 933
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 933
attgggctca gcatggag 18
<210> 934
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 934
tccttaacca ttaggcca 18
<210> 935
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 935
tggccctagt gagtaccg 18
<210> 936
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 936
gcccagtttg gtgcaggg 18
<210> 937
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 937
ggcgggaagg caggtcag 18
<210> 938
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 938
cagtttacca atgtcagc 18
<210> 939
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 939
atatattgtt acttagtc 18
<210> 940
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 940
cataggcaaa acagacaa 18
<210> 941
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 941
tagttgaatg ttttggaa 18
<210> 942
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 942
acggcggagg ctgaggcg 18
<210> 943
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 943
aggtgcaagc tggccggg 18
<210> 944
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 944
tgataccctg taagaata 18
<210> 945
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 945
aatatagcaa agggaatt 18
<210> 946
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 946
tagagataat tatgtccc 18
<210> 947
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 947
gcaattacag agccaggg 18
<210> 948
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 948
gcagaactgg atccgatc 18
<210> 949
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 949
caaagccagg atggtctc 18
<210> 950
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 950
ccaaagagat tccttttt 18
<210> 951
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 951
ggcctcattt atatatat 18
<210> 952
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 952
tatgggacaa tcatagct 18
<210> 953
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 953
aattctgata cattgtca 18
<210> 954
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 954
gatgactctt ccaaatgg 18
<210> 955
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 955
tcacttcatt attcaagc 18
<210> 956
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 956
gtgcagccgc cactggcc 18
<210> 957
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 957
cgataagatc tttttaaa 18
<210> 958
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 958
gacagtataa tctccatt 18
<210> 959
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 959
aggctaaagt cagcccac 18
<210> 960
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 960
cttgcaccct ggtttggg 18
<210> 961
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 961
tccctgtctg gttaggaa 18
<210> 962
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 962
acgcgcctgc cccgtgcc 18
<210> 963
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 963
ctcaaacctg gccacgct 18
<210> 964
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 964
gaaactggcg ggtctgtt 18
<210> 965
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 965
gggaggaatt tggcaatg 18
<210> 966
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 966
aaagagcacg gcatctat 18
<210> 967
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 967
aaactgtgag gcactggg 18
<210> 968
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 968
catttgacat tggcctgt 18
<210> 969
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 969
attattatca gcatcttc 18
<210> 970
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 970
ttgcagaggc aggaaggc 18
<210> 971
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 971
agcagcctgg tttagagg 18
<210> 972
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 972
tccacatctt ccagcctc 18
<210> 973
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 973
atacagactc agtctcct 18
<210> 974
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 974
agtcgaccgc actcctgc 18
<210> 975
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 975
gccctgaggg tccacagg 18
<210> 976
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 976
agggcagtgt cctacctc 18
<210> 977
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 977
gtcctccctt ccccacaa 18
<210> 978
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 978
ctgaattcct atcatgcg 18
<210> 979
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 979
gagaaagaag agtgtggt 18
<210> 980
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 980
cttaggacag attcctag 18
<210> 981
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 981
gtcagaagtg ttttccca 18
<210> 982
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 982
tccaatttta aacttaaa 18
<210> 983
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 983
ctactgttta aaaaggct 18
<210> 984
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 984
gtaaacacca tctctaaa 18
<210> 985
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 985
ctctgatact attataag 18
<210> 986
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 986
ctgagctatt tgagaatt 18
<210> 987
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 987
tctgcatata taattata 18
<210> 988
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 988
cacattgttt agattttc 18
<210> 989
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 989
ttagcacacc tgaaacgc 18
<210> 990
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 990
ggcaaagaag acaggaga 18
<210> 991
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 991
tgctgaggat gctttttt 18
<210> 992
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 992
gctggaagat gaggtggt 18
<210> 993
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 993
tgggtgttgg agaaaact 18
<210> 994
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 994
gctttaaaag ctcctcag 18
<210> 995
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 995
cgagcacttg tagttcca 18
<210> 996
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 996
gcagtgcttt aaaaatat 18
<210> 997
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 997
gaaatttcat gaaatatg 18
<210> 998
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 998
ttacttgcaa ttgaaaga 18
<210> 999
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 999
ggaaagacta ctcagagc 18
<210> 1000
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1000
gatgaaagag aataacaa 18
<210> 1001
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1001
acccattatc tgctcccc 18
<210> 1002
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1002
ttttcagtaa caacataa 18
<210> 1003
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1003
cctttagctt tccttttc 18
<210> 1004
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1004
caaattctgt ttctgtaa 18
<210> 1005
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1005
gcaaaaataa gtgaactg 18
<210> 1006
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1006
ttgcagtgac ttcttggg 18
<210> 1007
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1007
aaaccccttc aacatcag 18
<210> 1008
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1008
acaagagaaa cattttac 18
<210> 1009
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1009
cacttagtaa ccaagcaa 18
<210> 1010
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1010
catagatgat atattttg 18
<210> 1011
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1011
aaatcttgaa ctcctgaa 18
<210> 1012
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1012
ggagtttttg tgtttctt 18
<210> 1013
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1013
aaattcttaa tggttcag 18
<210> 1014
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1014
agatagatct cggctcac 18
<210> 1015
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1015
aacctttaat aaactttt 18
<210> 1016
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1016
gtccaagagg tttttttt 18
<210> 1017
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1017
gcagtcactg cattccag 18
<210> 1018
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1018
caaaaacagg gctaggca 18
<210> 1019
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1019
ttccctgaac aaatggca 18
<210> 1020
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1020
ctcaaatgta acatttta 18
<210> 1021
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1021
tacacctggc ccatgacc 18
<210> 1022
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1022
aagttctggc tcaagcaa 18
<210> 1023
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1023
acaactctct ggaaaaaa 18
<210> 1024
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1024
agtccacgcc tgcatctg 18
<210> 1025
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1025
caaggcaaca gagaggca 18
<210> 1026
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1026
aacatgcata taattacc 18
<210> 1027
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1027
ttggagggac aattctca 18
<210> 1028
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1028
cgaagaggcc aggactgc 18
<210> 1029
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1029
tttggctctg gtgatggt 18
<210> 1030
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1030
accaggcaaa gggacacc 18
<210> 1031
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1031
tgccagagac agaggttg 18
<210> 1032
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1032
cacacgcatg gcttcatg 18
<210> 1033
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1033
gaggaaggca tgaactaa 18
<210> 1034
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1034
tcccatgccc acgcatgt 18
<210> 1035
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1035
attattaacg aacaaaaa 18
<210> 1036
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1036
atgtccagat gtggatcg 18
<210> 1037
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1037
atcagacaga agagccat 18
<210> 1038
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1038
gcacagtgca acagtggg 18
<210> 1039
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1039
ggctttccct tcccttct 18
<210> 1040
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1040
agctgggaaa gtggcagg 18
<210> 1041
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1041
atgacaactt gatttggg 18
<210> 1042
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1042
gaccgcaacc ttgccaaa 18
<210> 1043
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1043
ctttcagaga caggctcg 18
<210> 1044
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1044
gggctcaccc ctgtagtt 18
<210> 1045
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1045
ctcttaaggc cgagtgca 18
<210> 1046
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1046
tgctaggcaa aaaaacaa 18
<210> 1047
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1047
taattagaaa cctcctcg 18
<210> 1048
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1048
caggtcatat atgaaatc 18
<210> 1049
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1049
tgtgcttccg aaagtagt 18
<210> 1050
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1050
gcatcaaatc catgcatt 18
<210> 1051
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1051
actctgaagc acagacag 18
<210> 1052
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1052
cttacctggg ctggatgg 18
<210> 1053
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1053
ttctgtctat agctagaa 18
<210> 1054
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1054
agatggcttc ctattgtt 18
<210> 1055
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1055
tggtttggtc aggcctca 18
<210> 1056
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1056
attgtaactc aaagtggg 18
<210> 1057
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1057
aaactctaca cccctggg 18
<210> 1058
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1058
cataccagga aggaagga 18
<210> 1059
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1059
tggacatatc agaatttg 18
<210> 1060
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1060
cccttattag tgtctaca 18
<210> 1061
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1061
acactctaga gaggtcca 18
<210> 1062
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1062
gacagtaccc acgacacg 18
<210> 1063
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1063
ccccattctg gatcctgg 18
<210> 1064
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1064
attgtctgta aaatgtgg 18
<210> 1065
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1065
attctgtctg acagagac 18
<210> 1066
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1066
cgatggtgca catctata 18
<210> 1067
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1067
cagtgtccgc tgaacaca 18
<210> 1068
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1068
aggaggatta ggaagaaa 18
<210> 1069
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1069
caaggaaggc gatctggg 18
<210> 1070
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1070
ggtggcactt gaacaagc 18
<210> 1071
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1071
ggtggaaagg gaacccgg 18
<210> 1072
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1072
ccccacgggt acacagag 18
<210> 1073
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1073
cgctgcgaac gatgcact 18
<210> 1074
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1074
gaatggtcct tcttacag 18
<210> 1075
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1075
ctgggaaaac caaggcaa 18
<210> 1076
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1076
cccaggctga ggaaggac 18
<210> 1077
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1077
gattggcttt tacatctt 18
<210> 1078
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1078
cggtttgagt acagtggt 18
<210> 1079
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1079
ctaacatctt agggcaca 18
<210> 1080
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1080
ttcctctgat gtcagaat 18
<210> 1081
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1081
ccccctcggt cgcccagg 18
<210> 1082
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1082
tgttttaact aaaagctt 18
<210> 1083
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1083
gtatgagggc atagatga 18
<210> 1084
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1084
atcacaccac agaatgtt 18
<210> 1085
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1085
tactcttctg tggcagct 18
<210> 1086
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1086
caacagcaag gccaggcg 18
<210> 1087
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1087
tagataattt gaaattta 18
<210> 1088
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1088
accttaatcc cagtattt 18
<210> 1089
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1089
tgcttatggt ccagctgt 18
<210> 1090
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1090
gagccaggct tcaaaacc 18
<210> 1091
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1091
tccagcacat ttaggcgg 18
<210> 1092
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1092
atctcaataa agctatcg 18
<210> 1093
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1093
cgcccgcggt gactcagc 18
<210> 1094
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1094
ggagtcaaga gtccaggg 18
<210> 1095
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1095
agaaggaatg atgaggaa 18
<210> 1096
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1096
gcagtacagt ttggtaat 18
<210> 1097
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1097
tggctactct ctcaggag 18
<210> 1098
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1098
gaccctaggt gggtaaag 18
<210> 1099
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1099
gtcccctgag gtgttgtg 18
<210> 1100
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1100
cccagacaac cttcacct 18
<210> 1101
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1101
tgggttaaga ctctgtct 18
<210> 1102
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1102
tggagccgag tgcggtgg 18
<210> 1103
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1103
tctcttctgg atatttcg 18
<210> 1104
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1104
cgatttaaaa tgaatgat 18
<210> 1105
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1105
agaacaaaga taacagtt 18
<210> 1106
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1106
gctaaattga ggcccggg 18
<210> 1107
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1107
ctttctcctt tcctcaat 18
<210> 1108
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1108
tctaagcgag acacacag 18
<210> 1109
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1109
tgatttctct ggaagaac 18
<210> 1110
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1110
gcctgtgtct tctaactc 18
<210> 1111
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1111
ggctgagaag ctgggacc 18
<210> 1112
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1112
tttttacttg agatgtca 18
<210> 1113
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1113
gtaggtgtca tcatcatc 18
<210> 1114
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1114
caacactgac tgagcaca 18
<210> 1115
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1115
gcattggctg ggctaggt 18
<210> 1116
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1116
tatttactat gcaaaata 18
<210> 1117
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1117
agcaccacag agcagatg 18
<210> 1118
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1118
ctcagtgtgg agttctgc 18
<210> 1119
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1119
catttttcaa ccacttaa 18
<210> 1120
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1120
gtaaggcttt gtgggcca 18
<210> 1121
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1121
tactttgcat tatttatt 18
<210> 1122
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1122
ttggctttca ttataatt 18
<210> 1123
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1123
ggacggttgg gaaatagg 18
<210> 1124
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1124
gagcaactgt tcataggg 18
<210> 1125
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1125
tctgcacatc gacacatc 18
<210> 1126
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1126
aggctaggcc ccatggct 18
<210> 1127
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1127
gcacccccat ccttcagc 18
<210> 1128
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1128
ccaggagatg aagtagca 18
<210> 1129
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1129
actcttggga aacaaagt 18
<210> 1130
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1130
ggaagcagcc agggacgg 18
<210> 1131
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1131
ctgcctggcc aattaaat 18
<210> 1132
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1132
caaactaata ttaacact 18
<210> 1133
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1133
tactcaattc caggcaag 18
<210> 1134
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1134
aatggaagtt ctagtacg 18
<210> 1135
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1135
caatcacagt tctttttc 18
<210> 1136
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1136
gtcttaaaca taaacata 18
<210> 1137
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1137
tgagagggat ggccccca 18
<210> 1138
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1138
cgcataacac cacgcccg 18
<210> 1139
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1139
gccaaaatca ggaatggg 18
<210> 1140
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1140
ggcagtccct gggttccg 18
<210> 1141
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1141
gttgaacctg accaagga 18
<210> 1142
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1142
agcatgagtt gtgccaag 18
<210> 1143
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1143
cccactccgc caccttga 18
<210> 1144
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1144
taccagagct gggtggtg 18
<210> 1145
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1145
acatttgcct cagaaatc 18
<210> 1146
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1146
gattcaggct gggagtgg 18
<210> 1147
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1147
ctccgagagc tgccactt 18
<210> 1148
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1148
tgcagcagac tcctaacg 18
<210> 1149
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1149
aggaatctca cttttgtc 18
<210> 1150
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1150
aggctgcccg tgccacca 18
<210> 1151
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1151
ttagtgaatg gccatcct 18
<210> 1152
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1152
aaactgcttg aatttggg 18
<210> 1153
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1153
tgtgagtccc ctgtaatc 18
<210> 1154
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1154
taaacagggc cttaatga 18
<210> 1155
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1155
tcctcccggc tctagaaa 18
<210> 1156
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1156
ggagacagcc aggcatgg 18
<210> 1157
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1157
ataatgtttt ttatagag 18
<210> 1158
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1158
gactggattt ttgtattt 18
<210> 1159
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1159
cggagtctta ttctgatg 18
<210> 1160
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1160
ccgcagcaat gcccctgc 18
<210> 1161
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1161
tctcgatccc cttcaaga 18
<210> 1162
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1162
ctgggtgtcc tttaccct 18
<210> 1163
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1163
cctgctccac gcctgcct 18
<210> 1164
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1164
tcagggcctt tatcctaa 18
<210> 1165
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1165
tcggctccac agtctttg 18
<210> 1166
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1166
caccactggg ttaggcag 18
<210> 1167
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1167
tcaccttccc gcctcccg 18
<210> 1168
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1168
ttgaagaggg tccagagg 18
<210> 1169
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1169
tgcccagaag gcaggtgg 18
<210> 1170
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1170
ggcccccgaa gtctgtgc 18
<210> 1171
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1171
cggtgcagga cagaggtg 18
<210> 1172
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1172
cgcgcaccac caccacgc 18
<210> 1173
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1173
tcaggctggg ccctaagc 18
<210> 1174
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1174
tcacccttcc ccagctcc 18
<210> 1175
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1175
tcagacccaa gtgataag 18
<210> 1176
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1176
gcagggtcta cacatgcg 18
<210> 1177
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1177
ctgagatgtt ctcttcct 18
<210> 1178
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1178
agctgcggta caggacag 18
<210> 1179
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1179
ccagtgaggg cccctctg 18
<210> 1180
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1180
gcccccagag gtgcatgg 18
<210> 1181
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1181
ggagcagcag acacatgc 18
<210> 1182
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1182
ggaagctact tcccatgc 18
<210> 1183
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1183
ggaggaggcc tgacaccc 18
<210> 1184
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1184
tttccctttg gtgttagc 18
<210> 1185
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1185
ccccaaagca atctatgt 18
<210> 1186
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1186
tctggaggga acactgcc 18
<210> 1187
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1187
ggttgaggtt gagggtag 18
<210> 1188
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1188
actcccgcag gccaaaca 18
<210> 1189
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1189
gagtgccaac aggcccag 18
<210> 1190
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1190
ttctaagtac aatttggg 18
<210> 1191
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1191
ttactggttg tgttttct 18
<210> 1192
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1192
gagtctcagt ctcactgt 18
<210> 1193
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1193
cattcctcct gctgctgt 18
<210> 1194
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1194
gctctgaaga gctccacg 18
<210> 1195
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1195
ctctcttcag ggccaccg 18
<210> 1196
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1196
ctctctcgcc ctgcatgg 18
<210> 1197
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1197
ctggacatcc tccgagaa 18
<210> 1198
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1198
cacccaggct gcggccca 18
<210> 1199
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1199
ctgtggtgca agcctgtg 18
<210> 1200
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1200
agacgagagt gcgcccac 18
<210> 1201
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1201
ccacataaat gttctaca 18
<210> 1202
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1202
ggtacaggaa aagatgcc 18
<210> 1203
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1203
atcagcttag gaactgac 18
<210> 1204
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1204
gtgcctcaca gttggctc 18
<210> 1205
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1205
gagaggctgt ggtgaggt 18
<210> 1206
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1206
gaaatcagaa tcctgaaa 18
<210> 1207
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1207
atgtggcttt ttcttgtt 18
<210> 1208
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1208
gtttttttct ggccgggc 18
<210> 1209
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1209
ttttcagtgg ataaggct 18
<210> 1210
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1210
acataaactc cttctttg 18
<210> 1211
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1211
tggtgaatgt tgaaattc 18
<210> 1212
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1212
aggacaagga ggccatgt 18
<210> 1213
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1213
tcaaatgaca gattctca 18
<210> 1214
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1214
catccctact ttctccct 18
<210> 1215
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1215
tagaatcttg ccttgtcg 18
<210> 1216
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1216
gatacagaca tacattgt 18
<210> 1217
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1217
aattctttgt gatgatgg 18
<210> 1218
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1218
gcacatattt acatttta 18
<210> 1219
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1219
ggtgagagag ccagcctc 18
<210> 1220
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1220
caaacagcct cccatgaa 18
<210> 1221
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1221
atatcctaag cattgtct 18
<210> 1222
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1222
tacagtggct cctgtaat 18
<210> 1223
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1223
gctcatcaaa gcaaaaac 18
<210> 1224
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1224
ctgggctgtc ggatctgg 18
<210> 1225
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1225
aagccaccat gcctgtaa 18
<210> 1226
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1226
acaccatcac ggctcagt 18
<210> 1227
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1227
agggagttgg aaaaactg 18
<210> 1228
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1228
caggtttgag aagccctg 18
<210> 1229
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1229
agacccaccg gcacattc 18
<210> 1230
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1230
atttccagcg ggctttac 18
<210> 1231
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1231
gcttgctcgc aaggacgc 18
<210> 1232
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1232
ccacagcacg gcgcatgg 18
<210> 1233
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1233
acaccccctc ctagaata 18
<210> 1234
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1234
accaccttca gcccaact 18
<210> 1235
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1235
taagctggag gcttagga 18
<210> 1236
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1236
gaacctcccg ccttagtc 18
<210> 1237
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1237
tatatgattg ttttttga 18
<210> 1238
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1238
aggagcctcg ggtgccca 18
<210> 1239
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1239
tcaggccagg cattttct 18
<210> 1240
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1240
cacttagcag acactggt 18
<210> 1241
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1241
tcctctggcc gagctcac 18
<210> 1242
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1242
acagcgcggg acacacgg 18
<210> 1243
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1243
gcatctcttc tcaccagg 18
<210> 1244
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1244
ggatacctgg agggcagg 18
<210> 1245
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1245
tgaggccagc actgaggg 18
<210> 1246
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1246
actggaacca tcccgaat 18
<210> 1247
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1247
gcagtggcct tgtgtggg 18
<210> 1248
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1248
accctgagct gccagctg 18
<210> 1249
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1249
ctgcacactc agtgtcct 18
<210> 1250
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1250
ctggaaaggc aggagtgg 18
<210> 1251
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1251
aagagcctct gggaaaaa 18
<210> 1252
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1252
ggtgtaactc aatgagaa 18
<210> 1253
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1253
ggctacctgg tttatgat 18
<210> 1254
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1254
ggagcgagct ggagccac 18
<210> 1255
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1255
gctcactccg ctcactgc 18
<210> 1256
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1256
ctaggtctta ttctattt 18
<210> 1257
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1257
aggtttttgt tgtgtgtt 18
<210> 1258
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1258
cctcttcacc ttaaaaaa 18
<210> 1259
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1259
aaacaaagtc acagaggg 18
<210> 1260
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1260
aggatcactt tcttttct 18
<210> 1261
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1261
ttgctgagtc tcactctg 18
<210> 1262
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1262
cagaatctat agctgtgt 18
<210> 1263
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1263
atactttcca cagggaga 18
<210> 1264
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1264
gaagaagggt ccctctct 18
<210> 1265
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1265
atgagagtac aactccat 18
<210> 1266
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1266
accctttcag gccgggcg 18
<210> 1267
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1267
taagtaaagt ctgttttt 18
<210> 1268
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1268
tagaatggtg tttggata 18
<210> 1269
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1269
gcagtctaca gggcaaag 18
<210> 1270
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1270
acctttttat ttcctccg 18
<210> 1271
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1271
agctccaggt gattgaga 18
<210> 1272
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1272
gtcgccatgt aagaaatg 18
<210> 1273
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1273
agggagactg atatggtt 18
<210> 1274
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1274
atattgcttg acctcagg 18
<210> 1275
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1275
agtggttctc gctttttt 18
<210> 1276
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1276
caagacaggc aggcagag 18
<210> 1277
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1277
gtgcttggct gcgcttct 18
<210> 1278
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1278
cagacctcta tcttttag 18
<210> 1279
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1279
aggagggtct ttcccgtg 18
<210> 1280
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1280
aactgggcca ccatgaga 18
<210> 1281
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1281
cctgccgctc ggccgtcc 18
<210> 1282
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1282
cgccctgccg ctcggccg 18
<210> 1283
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1283
gtgggcgcgc gcgagcgc 18
<210> 1284
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1284
ctagtgggcg cgcgcgag 18
<210> 1285
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1285
ccactagtgg gcgcgcgc 18
<210> 1286
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1286
cggccactag tgggcgcg 18
<210> 1287
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1287
ctccggccac tagtgggc 18
<210> 1288
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1288
ctcctccggc cactagtg 18
<210> 1289
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1289
cttctcctcc ggccacta 18
<210> 1290
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1290
agccttctcc tccggcca 18
<210> 1291
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1291
gggagccttc tcctccgg 18
<210> 1292
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1292
cgcgggagcc ttctcctc 18
<210> 1293
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1293
ctccgcggga gccttctc 18
<210> 1294
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1294
ggcctccgcg ggagcctt 18
<210> 1295
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1295
cgcggcctcc gcgggagc 18
<210> 1296
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1296
cagcgcggcc tccgcggg 18
<210> 1297
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1297
gggcagcgcg gcctccgc 18
<210> 1298
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1298
ggcgggcagc gcggcctc 18
<210> 1299
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1299
acgcgagcct ccccaggg 18
<210> 1300
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1300
ggaacgcgag cctcccca 18
<210> 1301
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1301
gcgggaacgc gagcctcc 18
<210> 1302
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1302
gcagcgggaa cgcgagcc 18
<210> 1303
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1303
cgagcagcgg gaacgcga 18
<210> 1304
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1304
gcgcgagcag cgggaacg 18
<210> 1305
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1305
caggcgcgag cagcggga 18
<210> 1306
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1306
gcgcaggcgc gagcagcg 18
<210> 1307
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1307
gcggcgcagg cgcgagca 18
<210> 1308
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1308
cgggcggcgc aggcgcga 18
<210> 1309
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1309
cggcgggcgg cgcaggcg 18
<210> 1310
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1310
ggccggcggg cggcgcag 18
<210> 1311
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1311
tgaggccggc gggcggcg 18
<210> 1312
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1312
tcctgaggcc ggcgggcg 18
<210> 1313
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1313
cgttcctgag gccggcgg 18
<210> 1314
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1314
gccggcgaag agggcgcg 18
<210> 1315
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1315
cgcgccggcg aagagggc 18
<210> 1316
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1316
gcgcgcgccg gcgaagag 18
<210> 1317
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1317
agggcgcgcg ccggcgaa 18
<210> 1318
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1318
gcgagggcgc gcgccggc 18
<210> 1319
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1319
actgcgaggg cgcgcgcc 18
<210> 1320
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1320
gtgactgcga gggcgcgc 18
<210> 1321
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1321
gcggtgactg cgagggcg 18
<210> 1322
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1322
gtggcggtga ctgcgagg 18
<210> 1323
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1323
tgggtggcgg tgactgcg 18
<210> 1324
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1324
tggtgggtgg cggtgact 18
<210> 1325
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1325
agctggtggg tggcggtg 18
<210> 1326
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1326
cggagctggt gggtggcg 18
<210> 1327
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1327
tgccggagct ggtgggtg 18
<210> 1328
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1328
tggtgccgga gctggtgg 18
<210> 1329
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1329
tgttggtgcc ggagctgg 18
<210> 1330
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1330
tgctgttggt gccggagc 18
<210> 1331
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1331
cgctgctgtt ggtgccgg 18
<210> 1332
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1332
gggcggtggc agcggcgc 18
<210> 1333
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1333
ggtgggcggt ggcagcgg 18
<210> 1334
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1334
gaaggtgggc ggtggcag 18
<210> 1335
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1335
gcagaaggtg ggcggtgg 18
<210> 1336
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1336
gcggcagaag gtgggcgg 18
<210> 1337
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1337
gcggcggcag aaggtggg 18
<210> 1338
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1338
gtggcggcgg cagaaggt 18
<210> 1339
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1339
gtggtggcgg cggcagaa 18
<210> 1340
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1340
gctgtggtgg cggcggca 18
<210> 1341
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1341
gtggctgtgg tggcggcg 18
<210> 1342
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1342
aaggtggctg tggtggcg 18
<210> 1343
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1343
aaacccttct cacaaaac 18
<210> 1344
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1344
cctcctggtc cctcctcg 18
<210> 1345
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1345
cctatccaga cccactca 18
<210> 1346
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1346
cacaaccacc ccgggacg 18
<210> 1347
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1347
ggaccaggat ggtgtttt 18
<210> 1348
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1348
ggctttgata aaaatatt 18
<210> 1349
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1349
cgcctccggg atcaagca 18
<210> 1350
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1350
ggttcgcatt taagctag 18
<210> 1351
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1351
acggtcattc tcagccct 18
<210> 1352
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1352
taacctccag agcaactg 18
<210> 1353
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1353
ggcaggtggg ccacaaaa 18
<210> 1354
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1354
tcaaaaggca tgcacatt 18
<210> 1355
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1355
tagtattccg tcgccacg 18
<210> 1356
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1356
gagctgttgt ttttattg 18
<210> 1357
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1357
gccagggact gttttttg 18
<210> 1358
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1358
tcacctgata gtcgacag 18
<210> 1359
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1359
agttcacctg atagtcga 18
<210> 1360
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1360
caaagttcac ctgatagt 18
<210> 1361
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1361
gttcaaagtt cacctgat 18
<210> 1362
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1362
gattctttca ggccagcg 18
<210> 1363
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1363
ggagattctt tcaggcca 18
<210> 1364
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1364
atcttccgct gttggagt 18
<210> 1365
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1365
cacatcttcc gctgttgg 18
<210> 1366
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1366
tgtcacatct tccgctgt 18
<210> 1367
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1367
tgctgtcaca tcttccgc 18
<210> 1368
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1368
agggtgctgt cacatctt 18
<210> 1369
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1369
gagaaggtgg ctgtggtg 18
<210> 1370
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1370
gaggagaagg tggctgtg 18
<210> 1371
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1371
gcggaggagg agaaggtg 18
<210> 1372
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1372
acagcggagg aggagaag 18
<210> 1373
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1373
aggacagcgg aggaggag 18
<210> 1374
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1374
gagaggacag cggaggag 18
<210> 1375
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1375
cgggagagga cagcggag 18
<210> 1376
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1376
ggacgggaga ggacagcg 18
<210> 1377
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1377
cgaggacggg agaggaca 18
<210> 1378
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1378
aggcgaggac gggagagg 18
<210> 1379
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1379
cagaggcgag gacgggag 18
<210> 1380
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1380
cgacagaggc gaggacgg 18
<210> 1381
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1381
agtcgacaga ggcgagga 18
<210> 1382
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1382
gatagtcgac agaggcga 18
<210> 1383
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1383
cctgatagtc gacagagg 18
<210> 1384
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1384
ctggttcaaa gttcacct 18
<210> 1385
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1385
atcctggttc aaagttca 18
<210> 1386
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1386
gccatcctgg ttcaaagt 18
<210> 1387
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1387
tcagccatcc tggttcaa 18
<210> 1388
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1388
ggctcagcca tcctggtt 18
<210> 1389
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1389
cttcgaactc ctggcggg 18
<210> 1390
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1390
tcacttcgaa ctcctggc 18
<210> 1391
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1391
ccatcacttc gaactcct 18
<210> 1392
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1392
cttccatcac ttcgaact 18
<210> 1393
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1393
gatcttccat cacttcga 18
<210> 1394
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1394
cgtgatcttc catcactt 18
<210> 1395
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1395
tgtcccccaa cccgtacg 18
<210> 1396
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1396
tcctgtcccc caacccgt 18
<210> 1397
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1397
ctttcctgtc ccccaacc 18
<210> 1398
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1398
gatctttcct gtccccca 18
<210> 1399
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1399
cctgatcttt cctgtccc 18
<210> 1400
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1400
ccccctgatc tttcctgt 18
<210> 1401
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1401
agcccccctg atctttcc 18
<210> 1402
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1402
tgtagccccc ctgatctt 18
<210> 1403
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1403
tggtgtagcc cccctgat 18
<210> 1404
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1404
gcatggtgta gcccccct 18
<210> 1405
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1405
ggtgcatggt gtagcccc 18
<210> 1406
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1406
cttggtgcat ggtgtagc 18
<210> 1407
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1407
ggtcttggtg catggtgt 18
<210> 1408
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1408
cttggtcttg gtgcatgg 18
<210> 1409
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1409
cctcttggtc ttggtgca 18
<210> 1410
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1410
caccctcttg gtcttggt 18
<210> 1411
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1411
cgtgtcaccc tcttggtc 18
<210> 1412
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1412
gtccgtgtca ccctcttg 18
<210> 1413
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1413
agatccgtcc tcagtggg 18
<210> 1414
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1414
ctcagatccg tcctcagt 18
<210> 1415
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1415
ttcctcagat ccgtcctc 18
<210> 1416
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1416
cggttcctca gatccgtc 18
<210> 1417
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1417
gcccggttcc tcagatcc 18
<210> 1418
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1418
agagcccggt tcctcaga 18
<210> 1419
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1419
ttcagagccc ggttcctc 18
<210> 1420
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1420
ggtttcagag cccggttc 18
<210> 1421
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1421
agaggtttca gagcccgg 18
<210> 1422
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1422
atcagaggtt tcagagcc 18
<210> 1423
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1423
agcatcagag gtttcaga 18
<210> 1424
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1424
cttagcatca gaggtttc 18
<210> 1425
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1425
gctcttagca tcagaggt 18
<210> 1426
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1426
agtgctctta gcatcaga 18
<210> 1427
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1427
tggagtgctc ttagcatc 18
<210> 1428
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1428
tgttggagtg ctcttagc 18
<210> 1429
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1429
cgctgttgga gtgctctt 18
<210> 1430
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1430
ttccgctgtt ggagtgct 18
<210> 1431
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1431
ctaagggtgc tgtcacat 18
<210> 1432
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1432
ccactaaggg tgctgtca 18
<210> 1433
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1433
catccactaa gggtgctg 18
<210> 1434
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1434
cctcatccac taagggtg 18
<210> 1435
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1435
gctgtggttc cttctggg 18
<210> 1436
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1436
tcaggctctt gggtcacg 18
<210> 1437
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1437
ctttcaggct cttgggtc 18
<210> 1438
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1438
ccactttcag gctcttgg 18
<210> 1439
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1439
ctccctcatc cactaagg 18
<210> 1440
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1440
gagctccctc atccacta 18
<210> 1441
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1441
cgggagctcc ctcatcca 18
<210> 1442
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1442
tgccgggagc tccctcat 18
<210> 1443
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1443
gcttgccggg agctccct 18
<210> 1444
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1444
cctgcttgcc gggagctc 18
<210> 1445
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1445
cagcctgctt gccgggag 18
<210> 1446
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1446
cggcagcctg cttgccgg 18
<210> 1447
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1447
gcgcggcagc ctgcttgc 18
<210> 1448
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1448
gctgcgcggc agcctgct 18
<210> 1449
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1449
tctgggatct ccgtgtgg 18
<210> 1450
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1450
ccttctggga tctccgtg 18
<210> 1451
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1451
gttccttctg ggatctcc 18
<210> 1452
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1452
gtggttcctt ctgggatc 18
<210> 1453
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1453
caatgcctgc ttcttcag 18
<210> 1454
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1454
gtctccaatg cctgcttc 18
<210> 1455
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1455
ggtgtctcca atgcctgc 18
<210> 1456
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1456
ttaccacttt caggctct 18
<210> 1457
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1457
ccaccttacc actttcag 18
<210> 1458
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1458
ggaccacctt accacttt 18
<210> 1459
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1459
cctggaccac cttaccac 18
<210> 1460
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1460
cttcctggac caccttac 18
<210> 1461
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1461
agccttcctg gaccacct 18
<210> 1462
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1462
ggaagccttc ctggacca 18
<210> 1463
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1463
ggaggaagcc ttcctgga 18
<210> 1464
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1464
ctcggaggaa gccttcct 18
<210> 1465
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1465
gctctcggag gaagcctt 18
<210> 1466
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1466
ctggctctcg gaggaagc 18
<210> 1467
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1467
ggcctggctc tcggagga 18
<210> 1468
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1468
tggtggctca gacctggg 18
<210> 1469
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1469
agctggtggc tcagacct 18
<210> 1470
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1470
atgagctggt ggctcaga 18
<210> 1471
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1471
gacatgagct ggtggctc 18
<210> 1472
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1472
ccggacatga gctggtgg 18
<210> 1473
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1473
atgccggaca tgagctgg 18
<210> 1474
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1474
ggcatgccgg acatgagc 18
<210> 1475
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1475
ccaggcatgc cggacatg 18
<210> 1476
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1476
gccccaggca tgccggac 18
<210> 1477
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1477
ggagccccag gcatgccg 18
<210> 1478
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1478
ggccctcagg caggaggg 18
<210> 1479
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1479
tgtccccgaa ggttggcg 18
<210> 1480
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1480
tcctgtcccc gaaggttg 18
<210> 1481
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1481
aggtcctgtc cccgaagg 18
<210> 1482
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1482
ctcaggtcct gtccccga 18
<210> 1483
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1483
gtcctcaggt cctgtccc 18
<210> 1484
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1484
tgtgtcctca ggtcctgt 18
<210> 1485
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1485
ctctgtgtcc tcaggtcc 18
<210> 1486
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1486
gccctctgtg tcctcagg 18
<210> 1487
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1487
gccgccctct gtgtcctc 18
<210> 1488
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1488
gcggccgccc tctgtgtc 18
<210> 1489
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1489
gtggcggccg ccctctgt 18
<210> 1490
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1490
tgcttgagca gctcaggg 18
<210> 1491
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1491
tggtgcttga gcagctca 18
<210> 1492
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1492
aagctggtgc ttgagcag 18
<210> 1493
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1493
tagaagctgg tgcttgag 18
<210> 1494
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1494
tcctagaagc tggtgctt 18
<210> 1495
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1495
gtctcctaga agctggtg 18
<210> 1496
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1496
caggtctcct agaagctg 18
<210> 1497
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1497
gtgcaggtct cctagaag 18
<210> 1498
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1498
ctggtgcagg tctcctag 18
<210> 1499
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1499
ctcctggtgc aggtctcc 18
<210> 1500
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1500
cccctcctgg tgcaggtc 18
<210> 1501
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1501
cggcccctcc tggtgcag 18
<210> 1502
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1502
cggcggcccc tcctggtg 18
<210> 1503
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1503
cagcggcggc ccctcctg 18
<210> 1504
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1504
cttcagcggc ggcccctc 18
<210> 1505
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1505
ccccttcagc ggcggccc 18
<210> 1506
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1506
tgcccccttc agcggcgg 18
<210> 1507
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1507
ccctgccccc ttcagcgg 18
<210> 1508
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1508
gccccctgcc cccttcag 18
<210> 1509
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1509
tttgccccct gccccctt 18
<210> 1510
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1510
ctctttgccc cctgcccc 18
<210> 1511
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1511
cctctctttg ccccctgc 18
<210> 1512
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1512
cggcctctct ttgccccc 18
<210> 1513
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1513
ccccggcctc tctttgcc 18
<210> 1514
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1514
gctccccggc ctctcttt 18
<210> 1515
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1515
cttgctcccc ggcctctc 18
<210> 1516
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1516
ctccttgctc cccggcct 18
<210> 1517
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1517
ctcctccttg ctccccgg 18
<210> 1518
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1518
cacctcctcc ttgctccc 18
<210> 1519
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1519
atccacctcc tccttgct 18
<210> 1520
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1520
cttcatccac ctcctcct 18
<210> 1521
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1521
ggtcttcatc cacctcct 18
<210> 1522
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1522
cgcggtcttc atccacct 18
<210> 1523
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1523
cgtcgcggtc ttcatcca 18
<210> 1524
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1524
ccgcccatct tgggctgg 18
<210> 1525
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1525
aggccgccca tcttgggc 18
<210> 1526
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1526
gggaggccgc ccatcttg 18
<210> 1527
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1527
ctctggcggc tgtctggg 18
<210> 1528
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1528
cttctctggc ggctgtct 18
<210> 1529
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1529
tggcttctct ggcggctg 18
<210> 1530
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1530
tggtggcttc tctggcgg 18
<210> 1531
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1531
tgctggtggc ttctctgg 18
<210> 1532
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1532
ggatgctggt ggcttctc 18
<210> 1533
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1533
ctgggatgct ggtggctt 18
<210> 1534
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1534
agcctgggat gctggtgg 18
<210> 1535
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1535
ggaagcctgg gatgctgg 18
<210> 1536
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1536
ctccgctggg aagcctgg 18
<210> 1537
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1537
accctccgct gggaagcc 18
<210> 1538
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1538
ggcaccctcc gctgggaa 18
<210> 1539
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1539
gatggcaccc tccgctgg 18
<210> 1540
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1540
aggaaatcca cagggagg 18
<210> 1541
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1541
gagaggaaat ccacaggg 18
<210> 1542
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1542
ttggagagga aatccaca 18
<210> 1543
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1543
actttggaga ggaaatcc 18
<210> 1544
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1544
ggaaactttg gagaggaa 18
<210> 1545
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1545
tgtggaaact ttggagag 18
<210> 1546
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1546
ctctgtggaa actttgga 18
<210> 1547
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1547
gatctctgtg gaaacttt 18
<210> 1548
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1548
tgggatctct gtggaaac 18
<210> 1549
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1549
ggctgggatc tctgtgga 18
<210> 1550
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1550
tgaggctggg atctctgt 18
<210> 1551
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1551
ctctgaggct gggatctc 18
<210> 1552
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1552
gtcgggctct gaggctgg 18
<210> 1553
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1553
cccgtcgggc tctgaggc 18
<210> 1554
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1554
ctacactggg cccgtcgg 18
<210> 1555
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1555
gccctacact gggcccgt 18
<210> 1556
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1556
cccgccctac actgggcc 18
<210> 1557
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1557
tggcccgccc tacactgg 18
<210> 1558
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1558
ctttggcccg ccctacac 18
<210> 1559
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1559
gccctttggc ccgcccta 18
<210> 1560
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1560
cctgcccttt ggcccgcc 18
<210> 1561
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1561
catcctgccc tttggccc 18
<210> 1562
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1562
gggcatcctg ccctttgg 18
<210> 1563
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1563
ttgggtgtga tttccacg 18
<210> 1564
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1564
gcctgctcct tctgcacg 18
<210> 1565
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1565
tgcgcctgct ccttctgc 18
<210> 1566
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1566
gagtgcgcct gctccttc 18
<210> 1567
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1567
tccgagtgcg cctgctcc 18
<210> 1568
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1568
tcctccgagt gcgcctgc 18
<210> 1569
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1569
tgctcctccg agtgcgcc 18
<210> 1570
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1570
aaatgctcct ccgagtgc 18
<210> 1571
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1571
cccaaatgct cctccgag 18
<210> 1572
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1572
cttcccaaat gctcctcc 18
<210> 1573
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1573
gcccttccca aatgctcc 18
<210> 1574
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1574
gcagcccttc ccaaatgc 18
<210> 1575
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1575
aatgcagccc ttcccaaa 18
<210> 1576
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1576
ctggaaatgc agcccttc 18
<210> 1577
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1577
cccctggaaa tgcagccc 18
<210> 1578
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1578
gggcccctgg aaatgcag 18
<210> 1579
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1579
tctggcccct ctccaggg 18
<210> 1580
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1580
gcctctggcc cctctcca 18
<210> 1581
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1581
cgggcctctg gcccctct 18
<210> 1582
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1582
ccccgggcct ctggcccc 18
<210> 1583
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1583
gtcctctccc aaagaggg 18
<210> 1584
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1584
tgtgtcctct cccaaaga 18
<210> 1585
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1585
ttttgtgtcc tctcccaa 18
<210> 1586
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1586
ctctggaagg tcagcctc 18
<210> 1587
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1587
gggctctgga aggtcagc 18
<210> 1588
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1588
agagggctct ggaaggtc 18
<210> 1589
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1589
cctccaccca gcatggtg 18
<210> 1590
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1590
tcaagtcacc ctttctcc 18
<210> 1591
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1591
ttcagacaat ttttctag 18
<210> 1592
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1592
tcagactccg ccagcttt 18
<210> 1593
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1593
tcttttccct ttggtgtt 18
<210> 1594
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1594
tttcccccaa tgatttgc 18
<210> 1595
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1595
ccacgactcc cacaagat 18
<210> 1596
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1596
tgaggttgag ggtaggtg 18
<210> 1597
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1597
agtggttgag gttgaggg 18
<210> 1598
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1598
caggcacttg gaaactgc 18
<210> 1599
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1599
ttgtactctt tttcccct 18
<210> 1600
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1600
ttaggagtgc aaggttgt 18
<210> 1601
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1601
tcctacattc ctcctgct 18
<210> 1602
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1602
gttgcagtgt tccactat 18
<210> 1603
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1603
ccagcagatg ccgacagc 18
<210> 1604
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1604
gggccctcac ccctgctt 18
<210> 1605
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1605
ccaagaaggg ctgctgag 18
<210> 1606
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1606
aagcagccac ccaggctg 18
<210> 1607
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1607
tatgaggagg gaggaaag 18
<210> 1608
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1608
ctgacatctc agcccaag 18
<210> 1609
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1609
caaggtgatc agcttagg 18
<210> 1610
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1610
agtccaaggt gatcagct 18
<210> 1611
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1611
cccacacaag cctcctct 18
<210> 1612
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1612
tttgtttggg ttcagttc 18
<210> 1613
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1613
ccttgatctg gttttgtt 18
<210> 1614
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1614
atcaagggag agaacgat 18
<210> 1615
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1615
aaaaggcaac aagccttt 18
<210> 1616
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1616
cgaggcaaaa agggaaat 18
<210> 1617
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1617
taactttgag cttcctgg 18
<210> 1618
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1618
taaggcttag aagatttg 18
<210> 1619
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1619
gacgatcatt ttttattc 18
<210> 1620
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1620
ggcttgacga tcattttt 18
<210> 1621
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1621
agatctcaga gtttgtag 18
<210> 1622
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1622
tcgctgaggt tccgcaac 18
<210> 1623
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1623
aggaggccat gtgaggct 18
<210> 1624
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1624
tggataaatc tctagtgc 18
<210> 1625
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1625
cactcctcct ttagagat 18
<210> 1626
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1626
ttgtaattcc ttctctgg 18
<210> 1627
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1627
taaccatccc tactttct 18
<210> 1628
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1628
actgaaatcg ctccttta 18
<210> 1629
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1629
ccaattatga ctgaaatc 18
<210> 1630
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1630
ggtcaaagtt ataaatat 18
<210> 1631
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1631
ggatttgatg caaagaaa 18
<210> 1632
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1632
gcgcaaccca gctactcg 18
<210> 1633
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1633
ctgtatacct atacttgg 18
<210> 1634
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1634
ccgttttctt accaccct 18
<210> 1635
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1635
ttacttgtct gaatcttc 18
<210> 1636
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1636
ttcatcccgt tttttttc 18
<210> 1637
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1637
gacctcagtg gctctttt 18
<210> 1638
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1638
tgtccaggat agtttgaa 18
<210> 1639
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1639
gctgagcaaa tgctcccg 18
<210> 1640
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1640
ctgaccccgt aggcagga 18
<210> 1641
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1641
accagcctga ggtcaagt 18
<210> 1642
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1642
caggtcctca cttcacaa 18
<210> 1643
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1643
ccgcctgctt gctcgcaa 18
<210> 1644
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1644
agtgacacgc caccctgg 18
<210> 1645
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1645
aaaaaggatg agtgacac 18
<210> 1646
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1646
ggtagccaga aaaaagga 18
<210> 1647
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1647
cctttggtag ccagaaaa 18
<210> 1648
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1648
ctgcaccttt ggtagcca 18
<210> 1649
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1649
attatctgca cctttggt 18
<210> 1650
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1650
taattatctg cacctttg 18
<210> 1651
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1651
cactgccgcc tcccggga 18
<210> 1652
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1652
ctcacactgc cgcctccc 18
<210> 1653
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1653
tactcacact gccgcctc 18
<210> 1654
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1654
ggtactcaca ctgccgcc 18
<210> 1655
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1655
aaggtactca cactgccg 18
<210> 1656
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1656
gtgtgaaggt actcacac 18
<210> 1657
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1657
gccacagcac ggcgcatg 18
<210> 1658
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1658
aataattcaa gccacagc 18
<210> 1659
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1659
accacttcct aataattc 18
<210> 1660
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1660
acgcactcac accacttc 18
<210> 1661
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1661
tcgcaagtgt acgcactc 18
<210> 1662
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1662
atgcagtgtc tcgcaagt 18
<210> 1663
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1663
tgatgggtat tctcagct 18
<210> 1664
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1664
ccgctcggcc gtccggcg 18
<210> 1665
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1665
ctgccgctcg gccgtccg 18
<210> 1666
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1666
ccagagctgg gtggtgtc 18
<210> 1667
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1667
tgtagactat ttgcacct 18
<210> 1668
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1668
atcactgatt ttgaagtc 18
<210> 1669
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1669
cccatcactg attttgaa 18
<210> 1670
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1670
actcccatca ctgatttt 18
<210> 1671
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1671
cttactccca tcactgat 18
<210> 1672
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1672
gctcttactc ccatcact 18
<210> 1673
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1673
tttgctctta ctcccatc 18
<210> 1674
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1674
aaatttgctc ttactccc 18
<210> 1675
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1675
atgaaatttg ctcttact 18
<210> 1676
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1676
aagatgaaat ttgctctt 18
<210> 1677
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1677
ggaaagatga aatttgct 18
<210> 1678
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1678
tttggaaaga tgaaattt 18
<210> 1679
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1679
catcaatttg gaaagatg 18
<210> 1680
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1680
acccatcaat ttggaaag 18
<210> 1681
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1681
cccacccatc aatttgga 18
<210> 1682
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1682
tagcccaccc atcaattt 18
<210> 1683
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1683
tactagccca cccatcaa 18
<210> 1684
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1684
tattactagc ccacccat 18
<210> 1685
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1685
ttttattact agcccacc 18
<210> 1686
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1686
atattttatt actagccc 18
<210> 1687
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1687
taaatatttt attactag 18
<210> 1688
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1688
ttttaaatat tttattac 18
<210> 1689
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1689
atgttttttt ttaaatat 18
<210> 1690
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1690
gccatgtttt tgaatgtt 18
<210> 1691
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1691
gtggccatgt ttttgaat 18
<210> 1692
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1692
gatgtggcca tgtttttg 18
<210> 1693
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1693
ttggatgtgg ccatgttt 18
<210> 1694
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1694
atgttggatg tggccatg 18
<210> 1695
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1695
gaaatgttgg atgtggcc 18
<210> 1696
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1696
gaggaaatgt tggatgtg 18
<210> 1697
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1697
cctgaggaaa tgttggat 18
<210> 1698
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1698
ttgcctgagg aaatgttg 18
<210> 1699
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1699
ccaaattcac ttttacag 18
<210> 1700
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1700
ttccaaattc acttttac 18
<210> 1701
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1701
atttccaaat tcactttt 18
<210> 1702
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1702
ttatttccaa attcactt 18
<210> 1703
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1703
ctttatttcc aaattcac 18
<210> 1704
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1704
aactttattt ccaaattc 18
<210> 1705
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1705
ataactttat ttccaaat 18
<210> 1706
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1706
gtaataactt tatttcca 18
<210> 1707
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1707
gagtaataac tttatttc 18
<210> 1708
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1708
cagagtaata actttatt 18
<210> 1709
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1709
atcagagtaa taacttta 18
<210> 1710
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1710
taatcagagt aataactt 18
<210> 1711
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1711
tttaatcaga gtaataac 18
<210> 1712
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1712
gcttccgctg ttggagtg 18
<210> 1713
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1713
tcagcttccg ctgttgga 18
<210> 1714
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1714
tcttcagctt ccgctgtt 18
<210> 1715
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1715
gcttcttcag cttccgct 18
<210> 1716
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1716
gcccccttgg cttttttg 18
<210> 1717
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1717
tcagccccct tggctttt 18
<210> 1718
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1718
accatcagcc cccttggc 18
<210> 1719
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1719
tcaccagagc tgggtggt 18
<210> 1720
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1720
ggttcaccag agctgggt 18
<210> 1721
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1721
ggaggttcac cagagctg 18
<210> 1722
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1722
tttggaggtt caccagag 18
<210> 1723
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1723
gattttggag gttcacca 18
<210> 1724
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1724
ttgcaccttc ccgcctcc 18
<210> 1725
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1725
agactatttg caccttcc 18
<210> 1726
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1726
cccttcgcgg tcccttcg 18
<210> 1727
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1727
ctgcccttcg cggtccct 18
<210> 1728
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1728
gcgctgccct tcgcggtc 18
<210> 1729
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1729
gtcccccaaa cccgtacg 18
<210> 1730
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1730
cctgtccccc aaacccgt 18
<210> 1731
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1731
tttcctgtcc cccaaacc 18
<210> 1732
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1732
ttgatctttc ctgtcccc 18
<210> 1733
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1733
cccttgatct ttcctgtc 18
<210> 1734
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1734
gcccccttga tctttcct 18
<210> 1735
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1735
gtagccccct tgatcttt 18
<210> 1736
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1736
ggtgtagccc ccttgatc 18
<210> 1737
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1737
catggtgtag cccccttg 18
<210> 1738
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1738
atgcgagctt gggtcacg 18
<210> 1739
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1739
accatgcgag cttgggtc 18
<210> 1740
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1740
ctgaccatgc gagcttgg 18
<210> 1741
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1741
gagctttgag ttgaggga 18
<210> 1742
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1742
tgcgagcttt gagttgag 18
<210> 1743
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1743
ccatgcgagc tttgagtt 18
<210> 1744
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1744
tgaccatgcg agctttga 18
<210> 1745
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1745
tactgaccat gcgagctt 18
<210> 1746
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1746
gatgtcttgg cttttttg 18
<210> 1747
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1747
gtgtggatgt cttggctt 18
<210> 1748
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1748
ttcagagggc tctggaag 18
<210> 1749
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1749
cttttcagag ggctctgg 18
<210> 1750
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1750
ctgcttttca gagggctc 18
<210> 1751
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1751
aggctgcttt tcagaggg 18
<210> 1752
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1752
agcaggctgc ttttcaga 18
<210> 1753
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1753
agcagcaggc tgcttttc 18
<210> 1754
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1754
agcagcagca ggctgctt 18
<210> 1755
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1755
cggagcagca gcaggctg 18
<210> 1756
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1756
ccgcggagca gcagcagg 18
<210> 1757
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1757
cccccgcgga gcagcagc 18
<210> 1758
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1758
cttcccccgc ggagcagc 18
<210> 1759
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1759
gggcttcccc cgcggagc 18
<210> 1760
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1760
gacgggcttc ccccgcgg 18
<210> 1761
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1761
gctgacgggc ttcccccg 18
<210> 1762
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1762
ccggctgacg ggcttccc 18
<210> 1763
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1763
gacccggctg acgggctt 18
<210> 1764
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1764
gagggacccg gctgacgg 18
<210> 1765
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1765
gttgagggac ccggctga 18
<210> 1766
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1766
tgagttgagg gacccggc 18
<210> 1767
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1767
ctttgagttg agggaccc 18
<210> 1768
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1768
ttttactgac catgcgag 18
<210> 1769
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1769
tgcttttact gaccatgc 18
<210> 1770
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1770
ctttgctttt actgacca 18
<210> 1771
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1771
cgtctttgct tttactga 18
<210> 1772
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1772
tcccgtcttt gcttttac 18
<210> 1773
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1773
ccagtcccgt ctttgctt 18
<210> 1774
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1774
cttccagtcc cgtctttg 18
<210> 1775
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1775
tcgcttccag tcccgtct 18
<210> 1776
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1776
tcatcgcttc cagtcccg 18
<210> 1777
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1777
ttgtcatcgc ttccagtc 18
<210> 1778
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1778
tttttgtcat cgcttcca 18
<210> 1779
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1779
ggttttagca gaggaacg 18
<210> 1780
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1780
caaggtttta gcagagga 18
<210> 1781
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1781
tttcaaggtt ttagcaga 18
<210> 1782
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1782
atttttcaag gttttagc 18
<210> 1783
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1783
cctatttttc aaggtttt 18
<210> 1784
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1784
ggcaaggcct atttttca 18
<210> 1785
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1785
taaggcaagg cctatttt 18
<210> 1786
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1786
ggctaaggca aggcctat 18
<210> 1787
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1787
tgagctacca ggagtggg 18
<210> 1788
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1788
gtctgagcta ccaggagt 18
<210> 1789
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1789
agggtctgag ctaccagg 18
<210> 1790
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1790
cagagggtct gagctacc 18
<210> 1791
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1791
gatcagaggg tctgagct 18
<210> 1792
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1792
ttggatcaga gggtctga 18
<210> 1793
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1793
ggagggttgg atcagagg 18
<210> 1794
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1794
gctggagggt tggatcag 18
<210> 1795
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1795
acacagcagg gctggagg 18
<210> 1796
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1796
ggcacacagc agggctgg 18
<210> 1797
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1797
ctctgggcac acagcagg 18
<210> 1798
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1798
tggctctggg cacacagc 18
<210> 1799
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1799
aggtggctct gggcacac 18
<210> 1800
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1800
ggaaggtggc tctgggca 18
<210> 1801
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1801
agaggaaggt ggctctgg 18
<210> 1802
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1802
aggagaggaa ggtggctc 18
<210> 1803
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1803
tttaggagag gaaggtgg 18
<210> 1804
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1804
gtatttagga gaggaagg 18
<210> 1805
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1805
gaagtgacag aagagacg 18
<210> 1806
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1806
cgggaagtga cagaagag 18
<210> 1807
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1807
gttcgggaag tgacagaa 18
<210> 1808
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1808
ccagttcggg aagtgaca 18
<210> 1809
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1809
ctgccagttc gggaagtg 18
<210> 1810
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1810
gaactgccag ttcgggaa 18
<210> 1811
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1811
ccagaactgc cagttcgg 18
<210> 1812
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1812
gctccagaac tgccagtt 18
<210> 1813
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1813
tttgctccag aactgcca 18
<210> 1814
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1814
tcctttgctc cagaactg 18
<210> 1815
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1815
atctcctttg ctccagaa 18
<210> 1816
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1816
ttcatctcct ttgctcca 18
<210> 1817
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1817
agtttcatct cctttgct 18
<210> 1818
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1818
cccttgagtt tcatctcc 18
<210> 1819
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1819
gcccccttga gtttcatc 18
<210> 1820
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1820
tcagccccct tgagtttc 18
<210> 1821
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1821
ccatcagccc ccttgagt 18
<210> 1822
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1822
ttaccatcag cccccttg 18
<210> 1823
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1823
cgcagagctg ggtggtgt 18
<210> 1824
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1824
agtcgcagag ctgggtgg 18
<210> 1825
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1825
cttagtcgca gagctggg 18
<210> 1826
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1826
ttgcttagtc gcagagct 18
<210> 1827
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1827
gacttgctta gtcgcaga 18
<210> 1828
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1828
ttcacctctc tcagatct 18
<210> 1829
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1829
aggttcacct ctctcaga 18
<210> 1830
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1830
tggaggttca cctctctc 18
<210> 1831
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1831
ttttggaggt tcacctct 18
<210> 1832
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1832
ttgagtttca tctccttt 18
<210> 1833
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1833
gttttaccat cagccccc 18
<210> 1834
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1834
gcggtgtggc gatcttcg 18
<210> 1835
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1835
cccgcggtgt ggcgatct 18
<210> 1836
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1836
ctccccgcgg tgtggcga 18
<210> 1837
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1837
ctgctccccg cggtgtgg 18
<210> 1838
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1838
gggctgctcc ccgcggtg 18
<210> 1839
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1839
ggcccttctg gcctggag 18
<210> 1840
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1840
gcctggccct tctggcct 18
<210> 1841
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1841
ttggcctggc ccttctgg 18
<210> 1842
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1842
gctggaatcc tggtggcg 18
<210> 1843
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1843
tttgctggaa tcctggtg 18
<210> 1844
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1844
gtttttgctg gaatcctg 18
<210> 1845
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1845
tgtctttgga gcgggcgg 18
<210> 1846
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1846
tggtgtcttt ggagcggg 18
<210> 1847
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1847
gggtggtgtc tttggagc 18
<210> 1848
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1848
gctgggtggt gtctttgg 18
<210> 1849
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1849
agagctgggt ggtgtctt 18
<210> 1850
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1850
ctggacttgc ttagtcgc 18
<210> 1851
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1851
tctctggact tgcttagt 18
<210> 1852
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1852
tcttctctgg acttgctt 18
<210> 1853
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1853
tggtcttctc tggacttg 18
<210> 1854
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1854
gggtggtctt ctctggac 18
<210> 1855
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1855
cagatctggg ccctgcag 18
<210> 1856
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1856
tctcagatct gggccctg 18
<210> 1857
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1857
ctctctcaga tctgggcc 18
<210> 1858
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1858
tgattttgga ggttcacc 18
<210> 1859
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1859
ccctgatttt ggaggttc 18
<210> 1860
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1860
atcccctgat tttggagg 18
<210> 1861
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1861
gcgatcccct gattttgg 18
<210> 1862
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1862
gctgcgatcc cctgattt 18
<210> 1863
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1863
gccgctgcga tcccctga 18
<210> 1864
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1864
gtagccgctg cgatcccc 18
<210> 1865
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1865
gctgtagccg ctgcgatc 18
<210> 1866
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1866
gctgctgtag ccgctgcg 18
<210> 1867
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1867
gcggctgccg ggagtgcc 18
<210> 1868
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1868
ggagcggctg ccgggagt 18
<210> 1869
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1869
tgcgggagcg gctgccgg 18
<210> 1870
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1870
accttcttgg gctcccgg 18
<210> 1871
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1871
gccaccttct tgggctcc 18
<210> 1872
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1872
actgccacct tcttgggc 18
<210> 1873
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1873
accactgcca ccttcttg 18
<210> 1874
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1874
cggaccactg ccaccttc 18
<210> 1875
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1875
gtacggacca ctgccacc 18
<210> 1876
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1876
ggagtacgga ccactgcc 18
<210> 1877
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1877
ggtggagtac ggaccact 18
<210> 1878
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1878
ttgggtggag tacggacc 18
<210> 1879
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1879
cggcgacttg ggtggagt 18
<210> 1880
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1880
agacggcgac ttgggtgg 18
<210> 1881
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1881
ggaagacggc gacttggg 18
<210> 1882
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1882
ggcggaagac ggcgactt 18
<210> 1883
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1883
cttggcggaa gacggcga 18
<210> 1884
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1884
gctcttggcg gaagacgg 18
<210> 1885
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1885
gcggctcttg gcggaaga 18
<210> 1886
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1886
caggcggctc ttggcgga 18
<210> 1887
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1887
ctgcaggcgg ctcttggc 18
<210> 1888
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1888
tgtctgcagg cggctctt 18
<210> 1889
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1889
ggctgtctgc aggcggct 18
<210> 1890
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1890
ggtctggcat gggcacgg 18
<210> 1891
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1891
tctcagtgga gccgatct 18
<210> 1892
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1892
ggttctcagt ggagccga 18
<210> 1893
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1893
tcaggttctc agtggagc 18
<210> 1894
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1894
gcttcaggtt ctcagtgg 18
<210> 1895
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1895
tgcaccttcc cgcctccc 18
<210> 1896
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1896
tatctgcacc ttcccgcc 18
<210> 1897
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1897
aattatctgc accttccc 18
<210> 1898
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1898
tgcacactgc cgcctccc 18
<210> 1899
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1899
actatttgca cactgccg 18
<210> 1900
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1900
tagactattt gcacactg 18
<210> 1901
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1901
ttgtagacta tttgcaca 18
<210> 1902
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1902
ctcctggttt atgatgga 18
<210> 1903
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1903
ggccacctcc tggtttat 18
<210> 1904
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1904
cacctggcca cctcctgg 18
<210> 1905
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1905
atctttttat ttcctccg 18
<210> 1906
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1906
tttcaatctt tttatttc 18
<210> 1907
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1907
ggtgcttcag gttctcag 18
<210> 1908
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1908
ggctggtgct tcaggttc 18
<210> 1909
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1909
cccggctggt gcttcagg 18
<210> 1910
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1910
cctcccggct ggtgcttc 18
<210> 1911
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1911
ccgcctcccg gctggtgc 18
<210> 1912
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1912
ttcccgcctc ccggctgg 18
<210> 1913
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1913
accttcccgc ctcccggc 18
<210> 1914
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1914
attaattatc tgcacctt 18
<210> 1915
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1915
cttattaatt atctgcac 18
<210> 1916
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1916
gcttcttatt aattatct 18
<210> 1917
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1917
ccagcttctt attaatta 18
<210> 1918
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1918
gatccagctt cttattaa 18
<210> 1919
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1919
taagatccag cttcttat 18
<210> 1920
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1920
tgctaagatc cagcttct 18
<210> 1921
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1921
cgttgctaag atccagct 18
<210> 1922
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1922
ccacacttgg actggacg 18
<210> 1923
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1923
gagccacact tggactgg 18
<210> 1924
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1924
tttgagccac acttggac 18
<210> 1925
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1925
tcctttgagc cacacttg 18
<210> 1926
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1926
ttatcctttg agccacac 18
<210> 1927
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1927
atattatcct ttgagcca 18
<210> 1928
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1928
ttgatattat cctttgag 18
<210> 1929
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1929
tgtttgatat tatccttt 18
<210> 1930
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1930
ctgccgcctc ccgggacg 18
<210> 1931
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1931
acactgccgc ctcccggg 18
<210> 1932
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1932
ggtttgtaga ctatttgc 18
<210> 1933
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1933
actggtttgt agactatt 18
<210> 1934
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1934
tcaactggtt tgtagact 18
<210> 1935
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1935
gctcaggtca actggttt 18
<210> 1936
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1936
cttgctcagg tcaactgg 18
<210> 1937
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1937
caccttgctc aggtcaac 18
<210> 1938
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1938
ctaatgagcc acacttgg 18
<210> 1939
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1939
tgcctaatga gccacact 18
<210> 1940
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1940
tgttgcctaa tgagccac 18
<210> 1941
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1941
ggatgttgcc taatgagc 18
<210> 1942
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1942
gatggatgtt gcctaatg 18
<210> 1943
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1943
tatgatggat gttgccta 18
<210> 1944
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1944
gtttatgatg gatgttgc 18
<210> 1945
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1945
ctggtttatg atggatgt 18
<210> 1946
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1946
tttacttcca cctggcca 18
<210> 1947
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1947
gattttactt ccacctgg 18
<210> 1948
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1948
tcagatttta cttccacc 18
<210> 1949
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1949
ttctcagatt ttacttcc 18
<210> 1950
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1950
agcttctcag attttact 18
<210> 1951
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1951
tcaagcttct cagatttt 18
<210> 1952
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1952
aagtcaagct tctcagat 18
<210> 1953
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1953
ttgaagtcaa gcttctca 18
<210> 1954
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1954
tccttgaagt caagcttc 18
<210> 1955
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1955
ctgtccttga agtcaagc 18
<210> 1956
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1956
actctgtcct tgaagtca 18
<210> 1957
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1957
tggactctgt ccttgaag 18
<210> 1958
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1958
gactggactc tgtccttg 18
<210> 1959
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1959
ttcgactgga ctctgtcc 18
<210> 1960
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1960
atcttcgact ggactctg 18
<210> 1961
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1961
ccaatcttcg actggact 18
<210> 1962
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1962
gacccaatct tcgactgg 18
<210> 1963
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1963
agggacccaa tcttcgac 18
<210> 1964
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1964
tccagggacc caatcttc 18
<210> 1965
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1965
ttgtccaggg acccaatc 18
<210> 1966
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1966
atattgtcca gggaccca 18
<210> 1967
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1967
gtgatattgt ccagggac 18
<210> 1968
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1968
tgggtgatat tgtccagg 18
<210> 1969
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1969
tttcctccgc cagggacg 18
<210> 1970
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1970
ttatttcctc cgccaggg 18
<210> 1971
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1971
tttttatttc ctccgcca 18
<210> 1972
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1972
gggtttcaat ctttttat 18
<210> 1973
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1973
gtcagcttgt gggtttca 18
<210> 1974
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1974
aaggtcagct tgtgggtt 18
<210> 1975
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1975
gcggaaggtc agcttgtg 18
<210> 1976
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1976
tctcgcggaa ggtcagct 18
<210> 1977
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1977
cgttctcgcg gaaggtca 18
<210> 1978
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1978
tctgtcttgg ctttggcg 18
<210> 1979
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1979
tggtctgtct tggctttg 18
<210> 1980
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1980
ccgtggtctg tcttggct 18
<210> 1981
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1981
gccccgtggt ctgtcttg 18
<210> 1982
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1982
acacgatctc cgccccgt 18
<210> 1983
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1983
tgtacacgat ctccgccc 18
<210> 1984
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1984
acttgtacac gatctccg 18
<210> 1985
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1985
gcgacttgta cacgatct 18
<210> 1986
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1986
ctggcgactt gtacacga 18
<210> 1987
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1987
ccactggcga cttgtaca 18
<210> 1988
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1988
acaccactgg cgacttgt 18
<210> 1989
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1989
cagacaccac tggcgact 18
<210> 1990
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1990
ccccagacac cactggcg 18
<210> 1991
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1991
tgtccccaga caccactg 18
<210> 1992
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1992
tgagatgccg tggagacg 18
<210> 1993
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1993
tgctgagatg ccgtggag 18
<210> 1994
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1994
cgatgctgcc ggtggagg 18
<210> 1995
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1995
tgtcgatgct gccggtgg 18
<210> 1996
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1996
ccatgtcgat gctgccgg 18
<210> 1997
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1997
ctaccatgtc gatgctgc 18
<210> 1998
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1998
agtctaccat gtcgatgc 18
<210> 1999
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 1999
gcgagtctac catgtcga 18
<210> 2000
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2000
agggaggcag acacctcg 18
<210> 2001
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2001
gccagggagg cagacacc 18
<210> 2002
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2002
cttggccagg gaggcaga 18
<210> 2003
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2003
ctgcttggcc agggaggc 18
<210> 2004
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2004
accctgcttg gccaggga 18
<210> 2005
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2005
cctgatcaca aaccctgc 18
<210> 2006
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2006
gggcctgatc acaaaccc 18
<210> 2007
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2007
ttattgaccg ccccaggg 18
<210> 2008
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2008
caattattga ccgcccca 18
<210> 2009
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2009
ccacaattat tgaccgcc 18
<210> 2010
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2010
tctccacaat tattgacc 18
<210> 2011
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2011
tcctctccac aattattg 18
<210> 2012
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2012
ctctcctctc cacaatta 18
<210> 2013
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2013
attctctcct ctccacaa 18
<210> 2014
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2014
ctcattctct cctctcca 18
<210> 2015
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2015
tctctcattc tctcctct 18
<210> 2016
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2016
cactctctca ttctctcc 18
<210> 2017
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2017
ccacactctc tcattctc 18
<210> 2018
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2018
tttccacact ctctcatt 18
<210> 2019
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2019
ttttttccac actctctc 18
<210> 2020
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2020
cttttttttt ccacactc 18
<210> 2021
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2021
attctttttt tttccaca 18
<210> 2022
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2022
gtcattattc tttttttt 18
<210> 2023
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2023
cgggtcatta ttcttttt 18
<210> 2024
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2024
ggccgggtca ttattctt 18
<210> 2025
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2025
ctgcgaggag cagctggg 18
<210> 2026
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2026
gaactgcgag gagcagct 18
<210> 2027
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2027
accgaactgc gaggagca 18
<210> 2028
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2028
ttaaccgaac tgcgagga 18
<210> 2029
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2029
caattaaccg aactgcga 18
<210> 2030
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2030
aaccaattaa ccgaactg 18
<210> 2031
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2031
attaaccaat taaccgaa 18
<210> 2032
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2032
gtgattaacc aattaacc 18
<210> 2033
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2033
taagtgatta accaatta 18
<210> 2034
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2034
ggttaagtga ttaaccaa 18
<210> 2035
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2035
gcaggttaag tgattaac 18
<210> 2036
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2036
aaagcaggtt aagtgatt 18
<210> 2037
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2037
acaaaagcag gttaagtg 18
<210> 2038
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2038
gtgacaaaag caggttaa 18
<210> 2039
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2039
cgagtgacaa aagcaggt 18
<210> 2040
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2040
agccgagtga caaaagca 18
<210> 2041
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2041
caaagccgag tgacaaaa 18
<210> 2042
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2042
agccaaagcc gagtgaca 18
<210> 2043
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2043
ccgagccaaa gccgagtg 18
<210> 2044
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2044
gtcccgagcc aaagccga 18
<210> 2045
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2045
gaagtcccga gccaaagc 18
<210> 2046
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2046
tttgaagtcc cgagccaa 18
<210> 2047
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2047
gattttgaag tcccgagc 18
<210> 2048
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2048
actgattttg aagtcccg 18
<210> 2049
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2049
tgtttggatt tctatcgg 18
<210> 2050
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2050
tgacatggtg tttggatt 18
<210> 2051
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2051
gctgacatgg tgtttgga 18
<210> 2052
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2052
cgctgacatg gtgtttgg 18
<210> 2053
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2053
tcgctgacat ggtgtttg 18
<210> 2054
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2054
ctcgctgaca tggtgttt 18
<210> 2055
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2055
actcgctgac atggtgtt 18
<210> 2056
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2056
gactcgctga catggtgt 18
<210> 2057
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2057
ggactcgctg acatggtg 18
<210> 2058
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2058
ttatccagga aaaatatt 18
<210> 2059
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2059
ggattatcca ggaaaaat 18
<210> 2060
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2060
taggattatc caggaaaa 18
<210> 2061
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2061
ataggattat ccaggaaa 18
<210> 2062
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2062
tataggatta tccaggaa 18
<210> 2063
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2063
ctataggatt atccagga 18
<210> 2064
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2064
ccctatagga ttatccag 18
<210> 2065
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2065
tccctatagg attatcca 18
<210> 2066
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2066
tatccctata ggattatc 18
<210> 2067
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2067
agttatccct ataggatt 18
<210> 2068
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2068
aggcaagtta tccctata 18
<210> 2069
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2069
atcagcacct gactgcgg 18
<210> 2070
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2070
ttcagatcag cacctgac 18
<210> 2071
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2071
gacttcagat cagcacct 18
<210> 2072
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2072
aagacttcag atcagcac 18
<210> 2073
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2073
aaagacttca gatcagca 18
<210> 2074
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2074
caaagacttc agatcagc 18
<210> 2075
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2075
ccaaagactt cagatcag 18
<210> 2076
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2076
accaaagact tcagatca 18
<210> 2077
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2077
caccaaagac ttcagatc 18
<210> 2078
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2078
ccaccaaaga cttcagat 18
<210> 2079
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2079
gcccaccaaa gacttcag 18
<210> 2080
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2080
tcagcccacc aaagactt 18
<210> 2081
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2081
taaagtcagc ccaccaaa 18
<210> 2082
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2082
gttattggga ctgacctt 18
<210> 2083
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2083
gatttgttat tgggactg 18
<210> 2084
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2084
cagtggagcc actcaacg 18
<210> 2085
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2085
cacctgtcca cagtggag 18
<210> 2086
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2086
aacaaacggg tcacctgt 18
<210> 2087
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2087
cgtgtaggag cagcagct 18
<210> 2088
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2088
ctttggtttg gctctttg 18
<210> 2089
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2089
gctggtggga gaggagcc 18
<210> 2090
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2090
atgcgggtgg ctgcctca 18
<210> 2091
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2091
gctggatgcg ggtggctg 18
<210> 2092
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2092
gtgctcaggg caggaagc 18
<210> 2093
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2093
caaagctcaa acagctga 18
<210> 2094
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2094
agaaccagga tcaaagct 18
<210> 2095
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2095
gctccgcctc agcagcac 18
<210> 2096
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2096
gtgtgcactc tctcccca 18
<210> 2097
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2097
ggctagcccg cagacgag 18
<210> 2098
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2098
cctgtgaagg tgctcaga 18
<210> 2099
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2099
gatccagtgc ccccagat 18
<210> 2100
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2100
ggagaggcta gggctcag 18
<210> 2101
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2101
agaggagtgg atggcagt 18
<210> 2102
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2102
tggcctgggt gaggtaac 18
<210> 2103
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2103
ctctggcctg ggtgaggt 18
<210> 2104
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2104
agggcaggtg gtggtttc 18
<210> 2105
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2105
gacattcctg gagtcccc 18
<210> 2106
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2106
tggcagacag acaggtcc 18
<210> 2107
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2107
agtcaaagaa ccagctcc 18
<210> 2108
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2108
tccctctggg aatgatga 18
<210> 2109
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2109
gcctccaggg caccgctc 18
<210> 2110
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2110
gcctgtggcc tccagggc 18
<210> 2111
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2111
aggaggcctg tggcctcc 18
<210> 2112
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2112
aataggaaca aagcaaca 18
<210> 2113
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2113
ctgtctttag caatagga 18
<210> 2114
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2114
tgtcctggac attcctgt 18
<210> 2115
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2115
tggaaaggca ggagtggg 18
<210> 2116
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2116
tctgaaaaat cttgctgg 18
<210> 2117
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2117
agcatctgaa aaatcttg 18
<210> 2118
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2118
atgagtatgc acagcatc 18
<210> 2119
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2119
aaagtgatca atatgatg 18
<210> 2120
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2120
gtcactccct ttcctgac 18
<210> 2121
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2121
acgcttaagt gtaaaaat 18
<210> 2122
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2122
aaatgtgttg tcgaaatt 18
<210> 2123
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2123
cagggtggaa aaatgtgt 18
<210> 2124
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2124
ttcccagctg ccatgagg 18
<210> 2125
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2125
tggagatgag agaggagg 18
<210> 2126
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2126
gcgcttacct gatagtcg 18
<210> 2127
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2127
tccactaacc tttcaggc 18
<210> 2128
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2128
gggagattct ggaacaca 18
<210> 2129
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2129
gggcccacct tccgctgt 18
<210> 2130
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2130
ctgtcacatc tagaaacc 18
<210> 2131
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2131
taccctcacc tgtggttc 18
<210> 2132
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2132
cttcttcagc tggtgtat 18
<210> 2133
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2133
ttcactgacc ttgggtca 18
<210> 2134
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2134
tttcaggctc tgtgtgga 18
<210> 2135
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2135
gacacagacc tttgagtt 18
<210> 2136
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2136
ccatgcgagc tgataaaa 18
<210> 2137
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2137
gtggatgtct taaacata 18
<210> 2138
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2138
tttccttacc ttgagttt 18
<210> 2139
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2139
atcagccccc tgtaaatg 18
<210> 2140
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2140
tcttcttacc agagctgg 18
<210> 2141
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2141
gaggttcacc tgggaagg 18
<210> 2142
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2142
cactctcacc ttcccgcc 18
<210> 2143
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2143
cctccaggcg cagcccta 18
<210> 2144
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2144
cctgaggagg gcactcac 18
<210> 2145
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2145
ggaaccgctg tgggtgcc 18
<210> 2146
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2146
tgggtggcag tgtattct 18
<210> 2147
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2147
ggagagctcg cgagcacc 18
<210> 2148
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2148
gaggtggcta cccacggc 18
<210> 2149
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2149
ccagaaggcc cagcacat 18
<210> 2150
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2150
cgaggcccag tgcccaga 18
<210> 2151
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2151
aggcccaggg ttccagaa 18
<210> 2152
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2152
aggcaagctg acacgcag 18
<210> 2153
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2153
caggaaaagg ccggacct 18
<210> 2154
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2154
agcaggaaaa ggccggac 18
<210> 2155
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2155
ttccccaagg tctctaac 18
<210> 2156
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2156
aggaaaggcc agtgaggg 18
<210> 2157
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2157
ttgttatgtg acttgagg 18
<210> 2158
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2158
attccccacc atgggaca 18
<210> 2159
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2159
aggacattcc ccaccatg 18
<210> 2160
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2160
agataaggag agaaggac 18
<210> 2161
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2161
atgctcagtg tggtcaga 18
<210> 2162
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2162
agggccggcc acctgcac 18
<210> 2163
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2163
tctgtctctg gcaacctg 18
<210> 2164
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2164
aacagggaag ctacttcc 18
<210> 2165
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2165
gggccttcaa tggaaagt 18
<210> 2166
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2166
ggtcgcctga ctctcacc 18
<210> 2167
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2167
ccctttctac acttggca 18
<210> 2168
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2168
tatctgcacc tttggtag 18
<210> 2169
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2169
tcttattaat tatctgca 18
<210> 2170
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2170
ttcttattaa ttatctgc 18
<210> 2171
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2171
agcttcttat taattatc 18
<210> 2172
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2172
cagcttctta ttaattat 18
<210> 2173
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2173
tccagcttct tattaatt 18
<210> 2174
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2174
atccagcttc ttattaat 18
<210> 2175
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2175
agatccagct tcttatta 18
<210> 2176
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2176
aagatccagc ttcttatt 18
<210> 2177
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2177
ctaagatcca gcttctta 18
<210> 2178
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2178
gctaagatcc agcttctt 18
<210> 2179
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2179
ttgctaagat ccagcttc 18
<210> 2180
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2180
gttgctaaga tccagctt 18
<210> 2181
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2181
gccacacttg gactggac 18
<210> 2182
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2182
agccacactt ggactgga 18
<210> 2183
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2183
tgagccacac ttggactg 18
<210> 2184
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2184
ttgagccaca cttggact 18
<210> 2185
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2185
cctttgagcc acacttgg 18
<210> 2186
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2186
atcctttgag ccacactt 18
<210> 2187
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2187
tatcctttga gccacact 18
<210> 2188
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2188
attatccttt gagccaca 18
<210> 2189
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2189
tattatcctt tgagccac 18
<210> 2190
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2190
gatattatcc tttgagcc 18
<210> 2191
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2191
tgatattatc ctttgagc 18
<210> 2192
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2192
gtttgatatt atcctttg 18
<210> 2193
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2193
gtgtttgata ttatcctt 18
<210> 2194
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2194
cgtgtttgat attatcct 18
<210> 2195
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2195
actgccgcct cccgggac 18
<210> 2196
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2196
tatttgcacc tggagatg 18
<210> 2197
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2197
cagggctacc tggtttat 18
<210> 2198
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2198
ggccacctcc tagaacac 18
<210> 2199
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2199
cccctttacc tttttatt 18
<210> 2200
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2200
ggtttcaatc tgcaagaa 18
<210> 2201
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2201
ttcgatttgt tattggga 18
<210> 2202
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2202
acttcgattt gttattgg 18
<210> 2203
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2203
gacttcgatt tgttattg 18
<210> 2204
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2204
tgacttcgat ttgttatt 18
<210> 2205
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2205
ctgacttcga tttgttat 18
<210> 2206
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2206
gctgacttcg atttgtta 18
<210> 2207
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2207
agctgacttc gatttgtt 18
<210> 2208
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2208
cagctgactt cgatttgt 18
<210> 2209
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2209
cccagctgac ttcgattt 18
<210> 2210
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2210
acgcccagct gacttcga 18
<210> 2211
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2211
tgccttatat atgctgaa 18
<210> 2212
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2212
ttacatgcct tatatatg 18
<210> 2213
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2213
cagttacatg ccttatat 18
<210> 2214
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2214
ttcagttaca tgccttat 18
<210> 2215
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2215
gttcagttac atgcctta 18
<210> 2216
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2216
aaagtgctgt gttcagtt 18
<210> 2217
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2217
cctctaaagt gctgtgtt 18
<210> 2218
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2218
gacttttctc aatgtaac 18
<210> 2219
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2219
ctgcagactt ttctcaat 18
<210> 2220
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2220
acctctctgc agactttt 18
<210> 2221
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2221
cacctctctg cagacttt 18
<210> 2222
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2222
gcacctctct gcagactt 18
<210> 2223
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2223
ggcacctctc tgcagact 18
<210> 2224
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2224
tggcacctct ctgcagac 18
<210> 2225
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2225
ctggcacctc tctgcaga 18
<210> 2226
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2226
tgctggcacc tctctgca 18
<210> 2227
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2227
tgatgctggc acctctct 18
<210> 2228
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2228
ccttgtgatg ctggcacc 18
<210> 2229
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2229
tttttagcat taaaagag 18
<210> 2230
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2230
gtgttttctt atttttag 18
<210> 2231
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2231
gcaaggtgtt ttcttatt 18
<210> 2232
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2232
taggcctctt ctgcattt 18
<210> 2233
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2233
ctggctaggc ctcttctg 18
<210> 2234
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2234
atcctggcta ggcctctt 18
<210> 2235
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2235
aaatcctggc taggcctc 18
<210> 2236
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2236
gaaatcctgg ctaggcct 18
<210> 2237
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2237
tgaaatcctg gctaggcc 18
<210> 2238
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2238
gtgaaatcct ggctaggc 18
<210> 2239
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2239
ggtgaaatcc tggctagg 18
<210> 2240
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2240
tggtgaaatc ctggctag 18
<210> 2241
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2241
ctggtgaaat cctggcta 18
<210> 2242
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2242
tgctggtgaa atcctggc 18
<210> 2243
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2243
cactgctggt gaaatcct 18
<210> 2244
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2244
accctggacc cgcctact 18
<210> 2245
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2245
gcgccaccct ggacccgc 18
<210> 2246
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2246
catgcgccac cctggacc 18
<210> 2247
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2247
gacatgcgcc accctgga 18
<210> 2248
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2248
tgacatgcgc caccctgg 18
<210> 2249
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2249
gtgacatgcg ccaccctg 18
<210> 2250
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2250
agtgacatgc gccaccct 18
<210> 2251
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2251
gagtgacatg cgccaccc 18
<210> 2252
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2252
tgagtgacat gcgccacc 18
<210> 2253
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2253
atgagtgaca tgcgccac 18
<210> 2254
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2254
cgatgagtga catgcgcc 18
<210> 2255
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2255
tttcgatgag tgacatgc 18
<210> 2256
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2256
tccactttcg atgagtga 18
<210> 2257
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2257
cagcacggcg catgggac 18
<210> 2258
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2258
acagcacggc gcatggga 18
<210> 2259
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2259
cacagcacgg cgcatggg 18
<210> 2260
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2260
agccacagca cggcgcat 18
<210> 2261
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2261
aagccacagc acggcgca 18
<210> 2262
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2262
tcaagccaca gcacggcg 18
<210> 2263
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2263
aattcaagcc acagcacg 18
<210> 2264
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2264
ctaataattc aagccaca 18
<210> 2265
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2265
gacatttgct cagcaaac 18
<210> 2266
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2266
cagacatttg ctcagcaa 18
<210> 2267
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2267
ccagacattt gctcagca 18
<210> 2268
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2268
cccagacatt tgctcagc 18
<210> 2269
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2269
acccagacat ttgctcag 18
<210> 2270
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2270
gacccagaca tttgctca 18
<210> 2271
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2271
agacccagac atttgctc 18
<210> 2272
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2272
aagacccaga catttgct 18
<210> 2273
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2273
gcaagaccca gacatttg 18
<210> 2274
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2274
tgtgcaagac ccagacat 18
<210> 2275
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2275
gtcattgtgc aagaccca 18
<210> 2276
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2276
tcttccatca cttcgaac 18
<210> 2277
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2277
atcttccatc acttcgaa 18
<210> 2278
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2278
tgatcttcca tcacttcg 18
<210> 2279
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2279
gtgatcttcc atcacttc 18
<210> 2280
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2280
atggtgtagc ccccctga 18
<210> 2281
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2281
catggtgtag cccccctg 18
<210> 2282
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2282
tgcatggtgt agcccccc 18
<210> 2283
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2283
gtgcatggtg tagccccc 18
<210> 2284
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2284
ccgtgtcacc ctcttggt 18
<210> 2285
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2285
tccgtgtcac cctcttgg 18
<210> 2286
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2286
cgtccgtgtc accctctt 18
<210> 2287
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2287
tcttagcatc agaggttt 18
<210> 2288
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2288
ctcttagcat cagaggtt 18
<210> 2289
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2289
tgctcttagc atcagagg 18
<210> 2290
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2290
gtgctcttag catcagag 18
<210> 2291
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2291
ctcctccgag tgcgcctg 18
<210> 2292
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2292
gctcctccga gtgcgcct 18
<210> 2293
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2293
atgctcctcc gagtgcgc 18
<210> 2294
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2294
aatgctcctc cgagtgcg 18
<210> 2295
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2295
caaatgctcc tccgagtg 18
<210> 2296
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2296
ttactgacca tgcgagct 18
<210> 2297
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2297
tttactgacc atgcgagc 18
<210> 2298
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2298
cttttactga ccatgcga 18
<210> 2299
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2299
gcttttactg accatgcg 18
<210> 2300
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2300
ttgcttttac tgaccatg 18
<210> 2301
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2301
actgcgagga gcagctgg 18
<210> 2302
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2302
aactgcgagg agcagctg 18
<210> 2303
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2303
cgaactgcga ggagcagc 18
<210> 2304
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2304
ccgaactgcg aggagcag 18
<210> 2305
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2305
aaccgaactg cgaggagc 18
<210> 2306
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2306
tgctcttact cccatcac 18
<210> 2307
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2307
ttgctcttac tcccatca 18
<210> 2308
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2308
atttgctctt actcccat 18
<210> 2309
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2309
aatttgctct tactccca 18
<210> 2310
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2310
accttcattt actgtcag 18
<210> 2311
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2311
caccttcatt tactgtca 18
<210> 2312
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2312
cacaccttca tttactgt 18
<210> 2313
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2313
acacaccttc atttactg 18
<210> 2314
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2314
aacacacctt catttact 18
<210> 2315
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2315
aaacacacct tcatttac 18
<210> 2316
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2316
caaacacacc ttcattta 18
<210> 2317
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2317
tcaaacacac cttcattt 18
<210> 2318
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2318
ttcaaacaca ccttcatt 18
<210> 2319
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2319
tttcaaacac accttcat 18
<210> 2320
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2320
ttggttttca aacacacc 18
<210> 2321
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2321
agcattaaaa gagaaaag 18
<210> 2322
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2322
ttatttttag cattaaaa 18
<210> 2323
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2323
tcttattttt agcattaa 18
<210> 2324
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2324
ttcttatttt tagcatta 18
<210> 2325
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2325
tttcttattt ttagcatt 18
<210> 2326
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2326
ttttcttatt tttagcat 18
<210> 2327
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2327
gttttcttat ttttagca 18
<210> 2328
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2328
tgttttctta tttttagc 18
<210> 2329
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2329
aggtgttttc ttattttt 18
<210> 2330
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2330
gggctgcaag gtgttttc 18
<210> 2331
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2331
gacaaaagca ggttaagt 18
<210> 2332
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2332
tgacaaaagc aggttaagt 19
<210> 2333
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2333
gtgacaaaag caggttaagt 20
<210> 2334
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2334
tgacaaaagc aggttaag 18
<210> 2335
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2335
gtgacaaaag caggttaag 19
<210> 2336
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2336
agtgacaaaa gcaggttaag 20
<210> 2337
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2337
agtgacaaaa gcaggttaa 19
<210> 2338
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2338
gagtgacaaa agcaggttaa 20
<210> 2339
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2339
agtgacaaaa gcaggtta 18
<210> 2340
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2340
gagtgacaaa agcaggtta 19
<210> 2341
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2341
cgagtgacaa aagcaggtta 20
<210> 2342
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2342
gagtgacaaa agcaggtt 18
<210> 2343
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2343
cgagtgacaa aagcaggtt 19
<210> 2344
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2344
ccgagtgaca aaagcaggtt 20
<210> 2345
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2345
ccgagtgaca aaagcaggt 19
<210> 2346
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2346
gccgagtgac aaaagcaggt 20
<210> 2347
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2347
ccgagtgaca aaagcagg 18
<210> 2348
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2348
gccgagtgac aaaagcagg 19
<210> 2349
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2349
agccgagtga caaaagcagg 20
<210> 2350
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2350
gccgagtgac aaaagcag 18
<210> 2351
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2351
agccgagtga caaaagcag 19
<210> 2352
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2352
aagccgagtg acaaaagcag 20
<210> 2353
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2353
aagccgagtg acaaaagca 19
<210> 2354
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2354
aaagccgagt gacaaaagca 20
<210> 2355
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2355
aagccgagtg acaaaagc 18
<210> 2356
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2356
aaagccgagt gacaaaagc 19
<210> 2357
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2357
caaagccgag tgacaaaagc 20
<210> 2358
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2358
aaagccgagt gacaaaag 18
<210> 2359
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2359
caaagccgag tgacaaaag 19
<210> 2360
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2360
ccaaagccga gtgacaaaag 20
<210> 2361
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2361
ccaaagccga gtgacaaaa 19
<210> 2362
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2362
gccaaagccg agtgacaaaa 20
<210> 2363
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2363
ccaaagccga gtgacaaa 18
<210> 2364
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2364
gccaaagccg agtgacaaa 19
<210> 2365
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2365
agccaaagcc gagtgacaaa 20
<210> 2366
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2366
gccaaagccg agtgacaa 18
<210> 2367
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2367
agccaaagcc gagtgacaa 19
<210> 2368
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2368
gagccaaagc cgagtgacaa 20
<210> 2369
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2369
gagccaaagc cgagtgaca 19
<210> 2370
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2370
cactgatttt gaagtccc 18
<210> 2371
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2371
tcactgattt tgaagtccc 19
<210> 2372
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2372
tcactgattt tgaagtcc 18
<210> 2373
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2373
atcactgatt ttgaagtcc 19
<210> 2374
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2374
catcactgat tttgaagtcc 20
<210> 2375
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2375
catcactgat tttgaagtc 19
<210> 2376
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2376
ccatcactga ttttgaagtc 20
<210> 2377
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2377
catcactgat tttgaagt 18
<210> 2378
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2378
ccatcactga ttttgaagt 19
<210> 2379
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2379
cccatcactg attttgaagt 20
<210> 2380
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2380
ccatcactga ttttgaag 18
<210> 2381
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2381
cccatcactg attttgaag 19
<210> 2382
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2382
tcccatcact gattttgaag 20
<210> 2383
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2383
tcccatcact gattttgaa 19
<210> 2384
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2384
ctcccatcac tgattttgaa 20
<210> 2385
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2385
tcccatcact gattttga 18
<210> 2386
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2386
ctcccatcac tgattttga 19
<210> 2387
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2387
actcccatca ctgattttga 20
<210> 2388
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2388
ctcccatcac tgattttg 18
<210> 2389
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2389
actcccatca ctgattttg 19
<210> 2390
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2390
tactcccatc actgattttg 20
<210> 2391
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2391
tactcccatc actgatttt 19
<210> 2392
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2392
ttactcccat cactgatttt 20
<210> 2393
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2393
tactcccatc actgattt 18
<210> 2394
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2394
ttactcccat cactgattt 19
<210> 2395
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2395
cttactccca tcactgattt 20
<210> 2396
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2396
ttactcccat cactgatt 18
<210> 2397
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2397
cttactccca tcactgatt 19
<210> 2398
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2398
tcttactccc atcactgatt 20
<210> 2399
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2399
tcttactccc atcactgat 19
<210> 2400
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2400
ctcttactcc catcactgat 20
<210> 2401
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2401
tcttactccc atcactga 18
<210> 2402
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2402
ctcttactcc catcactga 19
<210> 2403
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2403
gctcttactc ccatcactga 20
<210> 2404
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2404
ctcttactcc catcactg 18
<210> 2405
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2405
gctcttactc ccatcactg 19
<210> 2406
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2406
tgctcttact cccatcactg 20
<210> 2407
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2407
tgctcttact cccatcact 19
<210> 2408
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2408
ttgctcttac tcccatcact 20
<210> 2409
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2409
ttgctcttac tcccatcac 19
<210> 2410
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2410
tttgctctta ctcccatcac 20
<210> 2411
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2411
tttgctctta ctcccatca 19
<210> 2412
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2412
atttgctctt actcccatca 20
<210> 2413
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2413
atttgctctt actcccatc 19
<210> 2414
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2414
aatttgctct tactcccatc 20
<210> 2415
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2415
aatttgctct tactcccat 19
<210> 2416
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2416
aaatttgctc ttactcccat 20
<210> 2417
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2417
aaatttgctc ttactccca 19
<210> 2418
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2418
gaaatttgct cttactccca 20
<210> 2419
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2419
cgagccaaag ccgagtgaca 20
<210> 2420
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2420
gagccaaagc cgagtgac 18
<210> 2421
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2421
cgagccaaag ccgagtgac 19
<210> 2422
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2422
ccgagccaaa gccgagtgac 20
<210> 2423
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2423
cgagccaaag ccgagtga 18
<210> 2424
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2424
ccgagccaaa gccgagtga 19
<210> 2425
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2425
cccgagccaa agccgagtga 20
<210> 2426
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2426
cccgagccaa agccgagtg 19
<210> 2427
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2427
tcccgagcca aagccgagtg 20
<210> 2428
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2428
cccgagccaa agccgagt 18
<210> 2429
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2429
tcccgagcca aagccgagt 19
<210> 2430
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2430
gtcccgagcc aaagccgagt 20
<210> 2431
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2431
tcccgagcca aagccgag 18
<210> 2432
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2432
gtcccgagcc aaagccgag 19
<210> 2433
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2433
agtcccgagc caaagccgag 20
<210> 2434
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2434
agtcccgagc caaagccga 19
<210> 2435
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2435
aagtcccgag ccaaagccga 20
<210> 2436
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2436
agtcccgagc caaagccg 18
<210> 2437
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2437
aagtcccgag ccaaagccg 19
<210> 2438
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2438
gaagtcccga gccaaagccg 20
<210> 2439
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2439
aagtcccgag ccaaagcc 18
<210> 2440
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2440
gaagtcccga gccaaagcc 19
<210> 2441
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2441
tgaagtcccg agccaaagcc 20
<210> 2442
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2442
tgaagtcccg agccaaagc 19
<210> 2443
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2443
ttgaagtccc gagccaaagc 20
<210> 2444
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2444
acatccaaat aacaatat 18
<210> 2445
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2445
tcctgtctca aacaccta 18
<210> 2446
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2446
agcttatcac agtaggtg 18
<210> 2447
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2447
cctttgcttc acacacca 18
<210> 2448
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2448
tggttctaca acctgccc 18
<210> 2449
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2449
cctttgtaac cttggaac 18
<210> 2450
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2450
agttaaaaga tggcaacc 18
<210> 2451
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2451
ctgggcattt tgataaaa 18
<210> 2452
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2452
agtgccagac attttcaa 18
<210> 2453
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2453
ctggcacaac aggcattg 18
<210> 2454
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2454
gtggtacaga ggctgtgt 18
<210> 2455
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2455
ttgcagattc tgaatacc 18
<210> 2456
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2456
tatgattccc aggagtct 18
<210> 2457
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2457
gtgacccttc agggcaat 18
<210> 2458
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2458
atgcaggtgc cttgcagg 18
<210> 2459
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2459
cctgctgcca acagtaga 18
<210> 2460
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2460
ccctcacggg ctgttgtg 18
<210> 2461
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2461
acggtctgag catgaggc 18
<210> 2462
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2462
agccatggac ctgctctg 18
<210> 2463
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2463
gacagtatac cccacatc 18
<210> 2464
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2464
aagagtggta aaacctac 18
<210> 2465
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2465
gctcaccagc aggaactt 18
<210> 2466
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2466
aagggcccag tgtagcac 18
<210> 2467
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2467
ccaataagtg gcagtgat 18
<210> 2468
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2468
accatgcctg gcagatga 18
<210> 2469
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2469
cttagtcatc ttccctca 18
<210> 2470
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2470
atttctgaat tctttgcc 18
<210> 2471
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2471
cttacactct ggaaggtt 18
<210> 2472
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2472
tatccagggc tgagcagg 18
<210> 2473
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2473
ggagtcaatc tgccctgg 18
<210> 2474
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2474
cttccctgtg gcactttg 18
<210> 2475
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2475
atgcctcact caacaagg 18
<210> 2476
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2476
ctccactttg ggaccagg 18
<210> 2477
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2477
ggcacagcac ccacatgc 18
<210> 2478
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2478
tgaagtcccg agccaaag 18
<210> 2479
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2479
ttgaagtccc gagccaaa 18
<210> 2480
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2480
ttttgaagtc ccgagcca 18
<210> 2481
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2481
attttgaagt cccgagcc 18
<210> 2482
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2482
tgattttgaa gtcccgag 18
<210> 2483
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2483
ctgattttga agtcccga 18
<210> 2484
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2484
tgatcttcca tcacttcga 19
<210> 2485
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2485
gttttcaaac acaccttca 19
<210> 2486
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2486
ttttcttacc accctaaca 19
<210> 2487
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2487
cgttttctta ccaccctaa 19
<210> 2488
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2488
aaaccgtttt cttaccacc 19
<210> 2489
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2489
aaaaaccgtt ttcttacca 19
<210> 2490
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2490
agctcatcaa agcaaaaac 19
<210> 2491
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2491
tcaaaagact atgtatttt 19
<210> 2492
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2492
tgtaaataat tgccaagtg 19
<210> 2493
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2493
taagccacca tgcctgtaa 19
<210> 2494
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2494
tggacccgcc tacttgctc 19
<210> 2495
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2495
tttcgatgag tgacatgcg 19
<210> 2496
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2496
tgcttgctcg caaggacgc 19
<210> 2497
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2497
cgcctgcttg ctcgcaagg 19
<210> 2498
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2498
cccgcctgct tgctcgcaa 19
<210> 2499
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2499
gacccgcctg cttgctcgc 19
<210> 2500
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2500
tggacccgcc tgcttgctc 19
<210> 2501
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2501
cctggacccg cctgcttgc 19
<210> 2502
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2502
accctggacc cgcctgctt 19
<210> 2503
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2503
agtgacacgc caccctgga 19
<210> 2504
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2504
cctttggtag ccagaaaaa 19
<210> 2505
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2505
tctgcacctt tggtagcca 19
<210> 2506
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2506
acagcacggc gcatgggac 19
<210> 2507
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2507
ccacagcacg gcgcatggg 19
<210> 2508
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2508
agccacagca cggcgcatg 19
<210> 2509
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2509
ggtttgtttt ttaaacaatt 20
<210> 2510
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2510
gaacccaatg agagtagcaa 20
<210> 2511
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2511
ttgccaaaat caggaatggg 20
<210> 2512
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2512
tcagggcaat ctggaagcat 20
<210> 2513
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2513
actctccact ccatgtcaat 20
<210> 2514
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2514
cagagctcac agcaatgatc 20
<210> 2515
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2515
tcagcatgag ttgtgccaag 20
<210> 2516
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2516
ccagaggaac tgtgtgcatt 20
<210> 2517
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2517
ccaagttccc tgaggacatt 20
<210> 2518
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2518
gttgtgtttt ctggtttatt 20
<210> 2519
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2519
ttttttttta agttaggagt 20
<210> 2520
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2520
ttttactggt tgtgttttct 20
<210> 2521
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2521
cagctcttaa tgctgttata 20
<210> 2522
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2522
ttcagctcct gcacccagca 20
<210> 2523
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2523
ttttgctttt gctctgaaga 20
<210> 2524
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2524
ttgctattaa atataatgta 20
<210> 2525
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2525
gctttttaaa gtgacaactg 20
<210> 2526
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2526
ttccacataa atgttctaca 20
<210> 2527
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2527
ccctgattga ggagaggcaa 20
<210> 2528
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2528
atgttttttt ctggccgggc 20
<210> 2529
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2529
ttcagtatct gccacatact 20
<210> 2530
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2530
tgaatcaaag gacattaagc 20
<210> 2531
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2531
ggtgataaaa gttcacta 18
<210> 2532
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2532
ttgaagtccc gagccaaag 19
<210> 2533
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2533
tttgaagtcc cgagccaaag 20
<210> 2534
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2534
tttgaagtcc cgagccaaa 19
<210> 2535
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2535
ttttgaagtc ccgagccaaa 20
<210> 2536
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2536
ttttgaagtc ccgagccaa 19
<210> 2537
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2537
attttgaagt cccgagccaa 20
<210> 2538
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2538
tttgaagtcc cgagccaa 18
<210> 2539
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2539
attttgaagt cccgagcca 19
<210> 2540
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2540
gattttgaag tcccgagcca 20
<210> 2541
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2541
gattttgaag tcccgagcc 19
<210> 2542
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2542
tgattttgaa gtcccgagc 19
<210> 2543
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2543
ctgattttga agtcccgag 19
<210> 2544
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2544
actgattttg aagtcccgag 20
<210> 2545
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2545
actgattttg aagtcccga 19
<210> 2546
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2546
cactgatttt gaagtcccga 20
<210> 2547
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2547
cactgatttt gaagtcccg 19
<210> 2548
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2548
tcactgattt tgaagtcccg 20
<210> 2549
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2549
actgattttg aagtcccg 18
<210> 2550
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2550
ttgaagtccc gagccaaag 19
<210> 2551
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2551
tttgaagtcc cgagccaaa 19
<210> 2552
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2552
ttttgaagtc ccgagccaa 19
<210> 2553
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2553
attttgaagt cccgagcca 19
<210> 2554
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2554
gattttgaag tcccgagcc 19
<210> 2555
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2555
tgattttgaa gtcccgagc 19
<210> 2556
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2556
ctgattttga agtcccgag 19
<210> 2557
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2557
actgattttg aagtcccga 19
<210> 2558
<211> 19
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2558
cactgatttt gaagtcccg 19
<210> 2559
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2559
tttgaagtcc cgagccaaag 20
<210> 2560
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2560
ttttgaagtc ccgagccaaa 20
<210> 2561
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2561
attttgaagt cccgagccaa 20
<210> 2562
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2562
gattttgaag tcccgagcca 20
<210> 2563
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2563
actgattttg aagtcccgag 20
<210> 2564
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2564
cactgatttt gaagtcccga 20
<210> 2565
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2565
tcactgattt tgaagtcccg 20
<210> 2566
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2566
ttcttatttt tagcattaaa 20
<210> 2567
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2567
tttcttattt ttagcattaa 20
<210> 2568
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2568
ttttcttatt tttagcatta 20
<210> 2569
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2569
tgttttctta tttttagcat 20
<210> 2570
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2570
gtgttttctt atttttagca 20
<210> 2571
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2571
ggtgttttct tatttttagc 20
<210> 2572
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2572
ttggttttca aacacacctt 20
<210> 2573
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2573
tttggttttc aaacacacct 20
<210> 2574
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2574
cctcatgggc agaggcag 18
<210> 2575
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2575
cgttttctta ccacccta 18
<210> 2576
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2576
accgttttct taccaccc 18
<210> 2577
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2577
attatccttt gagccacact 20
<210> 2578
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2578
tattatcctt tgagccacac 20
<210> 2579
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2579
atattatcct ttgagccaca 20
<210> 2580
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2580
tgatattatc ctttgagcca 20
<210> 2581
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2581
ttgatattat cctttgagcc 20
<210> 2582
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2582
tttgatatta tcctttgagc 20
<210> 2583
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2583
ggaggcctgt ggcctcca 18
<210> 2584
<211> 18
<212> DNA
<213> Artificial sequence
<220>
<223> Synthetic oligonucleotide
<400> 2584
gaggaggcct gtggcctc 18
Claims (13)
12 내지 30개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1602의 핵염기 서열 중 적어도 8개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염으로서, 화합물이 타우 발현을 감소시킬 수 있는 것인 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
제1항에 있어서, 변형된 올리고뉴클레오타이드가
(i) 20개의 연결된 뉴클레오사이드로 이루어지거나;
(ii) 19개의 연결된 뉴클레오사이드로 이루어지거나; 또는
(iii) 18개의 연결된 뉴클레오사이드로 이루어지는 것인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
(i) 20개의 연결된 뉴클레오사이드로 이루어지거나;
(ii) 19개의 연결된 뉴클레오사이드로 이루어지거나; 또는
(iii) 18개의 연결된 뉴클레오사이드로 이루어지는 것인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
제1항에 있어서, 변형된 올리고뉴클레오타이드의 핵염기 서열이
(i) 서열 번호: 1602의 핵염기 서열을 포함하거나; 또는
(ii) 서열 번호: 1602의 핵염기 서열로 이루어지는 것인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
(i) 서열 번호: 1602의 핵염기 서열을 포함하거나; 또는
(ii) 서열 번호: 1602의 핵염기 서열로 이루어지는 것인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
제1항에 있어서, 하기를 포함하는 핵염기 서열을 갖는 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염:
(i) 서열 번호: 1602의 핵염기 서열의 적어도 12개의 인접 핵염기; 또는
(ii) 서열 번호: 1602의 핵염기 서열의 적어도 16개의 인접 핵염기.
(i) 서열 번호: 1602의 핵염기 서열의 적어도 12개의 인접 핵염기; 또는
(ii) 서열 번호: 1602의 핵염기 서열의 적어도 16개의 인접 핵염기.
제1항 내지 제4항 중 어느 한 항에 있어서,
(i) 갭머; 및/또는
(ii) 단일 가닥의 변형된 올리고뉴클레오타이드인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
(i) 갭머; 및/또는
(ii) 단일 가닥의 변형된 올리고뉴클레오타이드인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
제1항 내지 제4항 중 어느 한 항에 있어서,
(i) 변형된 올리고뉴클레오타이드의 적어도 1개의 뉴클레오사이드간 연결이 변형된 뉴클레오사이드간 연결이고, 예를 들어 여기서 (a) 변형된 올리고뉴클레오타이드의 적어도 1개의 변형된 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결이거나; (b) 변형된 올리고뉴클레오타이드의 적어도 1개의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이거나;
(ii) 변형된 올리고뉴클레오타이드의 적어도 1개의 뉴클레오사이드가 변형된 핵염기를 포함하며, 임의로 여기서 변형된 핵염기는 5-메틸시토신이거나;
(iii) 변형된 올리고뉴클레오타이드의 적어도 하나의 뉴클레오사이드는 변형된 당을 포함하며, 임의로 여기서 (a) 적어도 하나의 변형된 당은 비시클릭 당이고, 예를 들어 비시클릭 당은 4'-CH2-N(R)-O-2' 화학적 가교를 포함하고, R은 독립적으로 H 및 C1-C6 알킬로부터 선택되거나, 또는 비시클릭 당은 4'-CH-(R)-O-2' 화학적 가교를 포함하고, R은 메틸, H 또는 -CH2-O-CH3이거나; 또는 (b) 적어도 하나의 변형된 당은 2'-O-메톡시에틸 기 또는 2'-O-메틸 기를 포함하거나;
(iv) 변형된 올리고뉴클레오타이드의 적어도 하나의 뉴클레오사이드가 당 대용물을 포함하며, 임의로 여기서 적어도 하나의 당 대용물은 모폴리노 또는 펩타이드 핵산이거나; 또는
(v) 이들의 조합인 것인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
(i) 변형된 올리고뉴클레오타이드의 적어도 1개의 뉴클레오사이드간 연결이 변형된 뉴클레오사이드간 연결이고, 예를 들어 여기서 (a) 변형된 올리고뉴클레오타이드의 적어도 1개의 변형된 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결이거나; (b) 변형된 올리고뉴클레오타이드의 적어도 1개의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이거나;
(ii) 변형된 올리고뉴클레오타이드의 적어도 1개의 뉴클레오사이드가 변형된 핵염기를 포함하며, 임의로 여기서 변형된 핵염기는 5-메틸시토신이거나;
(iii) 변형된 올리고뉴클레오타이드의 적어도 하나의 뉴클레오사이드는 변형된 당을 포함하며, 임의로 여기서 (a) 적어도 하나의 변형된 당은 비시클릭 당이고, 예를 들어 비시클릭 당은 4'-CH2-N(R)-O-2' 화학적 가교를 포함하고, R은 독립적으로 H 및 C1-C6 알킬로부터 선택되거나, 또는 비시클릭 당은 4'-CH-(R)-O-2' 화학적 가교를 포함하고, R은 메틸, H 또는 -CH2-O-CH3이거나; 또는 (b) 적어도 하나의 변형된 당은 2'-O-메톡시에틸 기 또는 2'-O-메틸 기를 포함하거나;
(iv) 변형된 올리고뉴클레오타이드의 적어도 하나의 뉴클레오사이드가 당 대용물을 포함하며, 임의로 여기서 적어도 하나의 당 대용물은 모폴리노 또는 펩타이드 핵산이거나; 또는
(v) 이들의 조합인 것인
변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
제1항 내지 제4항 중 어느 한 항에 있어서,
a) 10개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
b) 9개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
c) 7개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
d) 8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
e) 8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
4개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나; 또는
f) 8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
6개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
4개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
a) 10개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
b) 9개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
c) 7개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
d) 8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나;
e) 8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
4개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
6개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하거나; 또는
f) 8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
6개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
4개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 변형된 당을 포함하는 것인 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
18개의 연결된 뉴클레오사이드로 이루어지고, 서열 번호: 1602의 핵염기 서열 중 적어도 12개의 인접 핵염기를 포함하는 핵염기 서열을 갖는 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염이며, 여기서 변형된 올리고뉴클레오타이드는
8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 2'-O-메톡시에틸 당을 포함하고, 적어도 1개의 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결이고, 적어도 1개의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이고, 각각의 시토신은 5-메틸시토신인, 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
8개의 연결된 데옥시뉴클레오사이드로 이루어진 갭 분절;
5개의 연결된 뉴클레오사이드로 이루어진 5' 윙 분절; 및
5개의 연결된 뉴클레오사이드로 이루어진 3' 윙 분절을 포함하고;
여기서 상기 갭 분절은 상기 5' 윙 분절과 상기 3' 윙 분절 사이에 위치하고, 각 윙 분절의 각각의 뉴클레오사이드는 2'-O-메톡시에틸 당을 포함하고, 적어도 1개의 뉴클레오사이드간 연결은 포스포로티오에이트 뉴클레오사이드간 연결이고, 적어도 1개의 뉴클레오사이드간 연결은 포스포디에스테르 뉴클레오사이드간 연결이고, 각각의 시토신은 5-메틸시토신인, 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염.
제1항 내지 제4항 중 어느 한 항의 변형된 올리고뉴클레오타이드, 또는 제8항의 단일 가닥 변형된 올리고뉴클레오타이드의 약제학적으로 허용가능한 염으로서, 나트륨 염인 약제학적으로 허용가능한 염.
제1항 내지 제4항 중 어느 한 항의 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염, 또는 제8항의 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염을 포함하는 공액된(conjugated) 안티센스 화합물.
(i) 제1항 내지 제4항 중 어느 한 항의 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염, 또는
(ii) 제8항의 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염, 또는
(iii) 제1항 내지 제4항 중 어느 한 항의 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염, 또는 제8항의 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염을 포함하는 공액된 안티센스 화합물,
및 약제학적으로 허용가능한 담체 또는 희석제 중 적어도 하나를 포함하며, 임의로, 여기서 약제학적으로 허용가능한 희석제는 포스페이트-완충 식염수(PBS)인 것인, 신경퇴행성 질환, 장애 또는 병태를 치료하는데 사용하기 위한 조성물.
(ii) 제8항의 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염, 또는
(iii) 제1항 내지 제4항 중 어느 한 항의 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염, 또는 제8항의 단일 가닥 변형된 올리고뉴클레오타이드 또는 그의 약제학적으로 허용가능한 염을 포함하는 공액된 안티센스 화합물,
및 약제학적으로 허용가능한 담체 또는 희석제 중 적어도 하나를 포함하며, 임의로, 여기서 약제학적으로 허용가능한 희석제는 포스페이트-완충 식염수(PBS)인 것인, 신경퇴행성 질환, 장애 또는 병태를 치료하는데 사용하기 위한 조성물.
제11항에 있어서, 신경퇴행성 질환, 장애 또는 병태는
a) 타우병증
b) 알츠하이머 질환, 전두측두엽 치매, FTDP-17, 진행성 핵상안근 마비, 만성 외상성 뇌증, 뇌피질 기저 신경절 퇴행증, 간질 또는 드라벳 증후군;
c) 알츠하이머 질환;
d) 전두측두엽 치매; 또는
e) 진행성 핵상안근 마비
인 조성물.
a) 타우병증
b) 알츠하이머 질환, 전두측두엽 치매, FTDP-17, 진행성 핵상안근 마비, 만성 외상성 뇌증, 뇌피질 기저 신경절 퇴행증, 간질 또는 드라벳 증후군;
c) 알츠하이머 질환;
d) 전두측두엽 치매; 또는
e) 진행성 핵상안근 마비
인 조성물.
제11항에 있어서, 척추강내 투여되는 것인 조성물.
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| AR109750A1 (es) | 2016-09-29 | 2019-01-23 | Ionis Pharmaceuticals Inc | Compuestos y métodos para reducir la expresión de tau |
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