DK3027618T3 - Polymorf af syk-hæmmere - Google Patents

Polymorf af syk-hæmmere Download PDF

Info

Publication number
DK3027618T3
DK3027618T3 DK14750289.2T DK14750289T DK3027618T3 DK 3027618 T3 DK3027618 T3 DK 3027618T3 DK 14750289 T DK14750289 T DK 14750289T DK 3027618 T3 DK3027618 T3 DK 3027618T3
Authority
DK
Denmark
Prior art keywords
polymorphy
sick
inhibitors
sick inhibitors
Prior art date
Application number
DK14750289.2T
Other languages
English (en)
Inventor
Peter Chee-Chu Fung
Dimitrios Stefanidis
Dragos Vizitiu
Tim G Elford
Michael Laird Hurrey
Original Assignee
Kronos Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51301367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3027618(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kronos Bio Inc filed Critical Kronos Bio Inc
Application granted granted Critical
Publication of DK3027618T3 publication Critical patent/DK3027618T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
DK14750289.2T 2013-07-30 2014-07-29 Polymorf af syk-hæmmere DK3027618T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361860197P 2013-07-30 2013-07-30
PCT/US2014/048733 WO2015017460A1 (en) 2013-07-30 2014-07-29 Polymorph of syk inhibitors

Publications (1)

Publication Number Publication Date
DK3027618T3 true DK3027618T3 (da) 2020-10-12

Family

ID=51301367

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14750289.2T DK3027618T3 (da) 2013-07-30 2014-07-29 Polymorf af syk-hæmmere

Country Status (32)

Country Link
US (4) US20160168155A1 (da)
EP (1) EP3027618B1 (da)
JP (1) JP6230709B2 (da)
KR (1) KR101810798B1 (da)
CN (1) CN105452252A (da)
AP (1) AP2016009008A0 (da)
AR (1) AR097158A1 (da)
AU (2) AU2014296308C1 (da)
CA (1) CA2919661C (da)
CL (1) CL2016000238A1 (da)
CR (1) CR20160098A (da)
DK (1) DK3027618T3 (da)
EA (2) EA201791873A1 (da)
ES (1) ES2822285T3 (da)
HK (1) HK1222390A1 (da)
HR (1) HRP20201582T1 (da)
HU (1) HUE052090T2 (da)
IL (1) IL243579A0 (da)
MD (1) MD4659B1 (da)
MX (1) MX2016001304A (da)
MY (1) MY176803A (da)
NZ (1) NZ715776A (da)
PE (1) PE20160862A1 (da)
PH (1) PH12016500169A1 (da)
PL (1) PL3027618T3 (da)
PT (1) PT3027618T (da)
SG (1) SG11201600385TA (da)
SI (1) SI3027618T1 (da)
SV (1) SV2016005149A (da)
TW (1) TW201602108A (da)
UY (1) UY35683A (da)
WO (1) WO2015017460A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201707798SA (en) 2008-12-08 2017-10-30 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
WO2011112995A1 (en) 2010-03-11 2011-09-15 Gilead Sciences, Inc. Imidazopyridines syk inhibitors
TW201602108A (zh) 2013-07-30 2016-01-16 吉李德康乃狄克公司 脾酪胺酸激酶（Ｓｙｋ）抑制劑之多晶型
MD4684B1 (ro) 2013-07-30 2020-03-31 Gilead Connecticut INc. Formulări pe bază de imidazopirazine în calitate de inhibitori SYK
ES2835549T3 (es) 2013-12-04 2021-06-22 Kronos Bio Inc Métodos de tratamiento de cánceres
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
CA2955180A1 (en) 2014-07-14 2016-01-21 Gilead Sciences, Inc. Combinations comprising entospletinib and a vinca-alkaloid for treating cancers
TW201639573A (zh) 2015-02-03 2016-11-16 吉李德科學股份有限公司 有關治療癌症之合併治療
JP2018513173A (ja) 2015-04-21 2018-05-24 ギリアード サイエンシーズ， インコーポレイテッド Ｓｙｋ阻害剤を用いた慢性移植片対宿主病の処置
US20170173034A1 (en) 2015-12-17 2017-06-22 Gilead Sciences, Inc. Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders
WO2017144010A1 (zh) * 2016-02-26 2017-08-31 苏州晶云药物科技有限公司 (6-(1H-吲唑-6-基)-N-[4-(4-吗啉基)苯基]咪唑并[1，2-a]吡嗪-8-胺)甲磺酸盐的新晶型
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
AU2017325844A1 (en) 2016-09-14 2019-03-07 Gilead Sciences, Inc. SYK inhibitors
JOP20180040A1 (ar) 2017-04-20 2019-01-30 Gilead Sciences Inc مثبطات pd-1/pd-l1
WO2018195471A1 (en) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Syk inhibitors in combination with hypomethylating agents
KR102399996B1 (ko) * 2017-08-25 2022-05-20 길리애드 사이언시즈, 인코포레이티드 Syk 억제제의 다형체
EP4227302A1 (en) 2018-02-13 2023-08-16 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
JP6899975B2 (ja) 2018-05-14 2021-07-07 ギリアード サイエンシーズ， インコーポレイテッド Ｍｃｌ−１阻害剤
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
WO2020172431A1 (en) 2019-02-22 2020-08-27 Gilead Sciences, Inc. Solid forms of condensed pyrazines as syk inhibitors
CN113402506B (zh) * 2021-06-17 2023-06-16 四川大学 中间体和制备方法及其在合成长春布宁上的应用

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607813B1 (fr) 1986-12-05 1989-03-31 Montpellier I Universite Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique
US5137876A (en) 1990-10-12 1992-08-11 Merck & Co., Inc. Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same
DE4327027A1 (de) 1993-02-15 1994-08-18 Bayer Ag Imidazoazine
DE4337609A1 (de) 1993-11-04 1995-05-11 Boehringer Ingelheim Kg Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE4337611A1 (de) 1993-11-04 1995-05-11 Boehringer Ingelheim Kg Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln
FR2711993B1 (fr) 1993-11-05 1995-12-01 Rhone Poulenc Rorer Sa Médicaments contenant des dérivés de 7H-imidazol[1,2-a]pyrazine-8-one, les nouveaux composés et leur préparation.
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ATE372966T1 (de) 1994-03-25 2007-09-15 Isotechnika Inc Verbesserung der effektivität von arzneimitteln duren deuterierung
FR2723373B1 (fr) 1994-08-02 1996-09-13 Rhone Poulenc Rorer Sa Forme purifiee de streptogramines, sa preparation et les compositions pharmaceutiques qui la contiennent
WO1996034866A1 (en) 1995-05-01 1996-11-07 Fujisawa Pharmaceutical Co., Ltd. Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors
US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
DE19948434A1 (de) 1999-10-08 2001-06-07 Gruenenthal Gmbh Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
JP2001302667A (ja) 2000-04-28 2001-10-31 Bayer Ag イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
GB0018473D0 (en) 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
DE10050663A1 (de) 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
US20040102455A1 (en) 2001-01-30 2004-05-27 Burns Christopher John Method of inhibiting kinases
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
WO2002076985A1 (en) 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
CA2476681A1 (en) 2002-02-19 2003-08-28 Bruce N. Rogers Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
WO2003089434A2 (en) 2002-04-19 2003-10-30 Cellular Genomics, Inc. IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES METHOD OF MAKING AND METHOD OF USE THEREOF
DE60326341D1 (de) 2002-05-14 2009-04-09 Xenova Ltd Verfahren zur herstellung von anthranilsäurederivat-hydrat
WO2004022562A1 (en) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
NZ538566A (en) 2002-09-19 2008-02-29 Schering Corp Imidazopyridines as cyclin dependent kinase inhibitors
KR20060010709A (ko) 2002-09-23 2006-02-02 쉐링 코포레이션 사이클린 의존성 키나제 억제제로서의 신규한 이미다조피라진
ES2293015T3 (es) 2002-09-23 2008-03-16 Schering Corporation Imidazopirazinas como inhibidores de cinasas dependientes de ciclinas.
US7189723B2 (en) 2003-02-10 2007-03-13 Cgi Pharmaceuticals, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
US7157460B2 (en) 2003-02-20 2007-01-02 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US7186832B2 (en) 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US20060183746A1 (en) 2003-06-04 2006-08-17 Currie Kevin S Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
WO2005047290A2 (en) 2003-11-11 2005-05-26 Cellular Genomics Inc. Imidazo[1,2-a] pyrazin-8-ylamines as kinase inhibitors
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
WO2005085252A1 (en) 2004-03-04 2005-09-15 Biofocus Discovery Limited Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP1812442A2 (en) 2004-11-10 2007-08-01 CGI Pharmaceuticals, Inc. Imidazo[1,2-a]pyrazin-8-ylamines useful as modulators of kinase activity
EP2757099B1 (en) 2005-05-12 2017-08-23 AbbVie Bahamas Limited Apoptosis promoters
JP5031760B2 (ja) 2005-11-10 2012-09-26 シェーリング コーポレイション プロテインキナーゼインヒビターとしてのイミダゾピラジン
EP2057158B8 (en) 2006-08-30 2015-09-30 Cellzome Limited Triazole derivatives as kinase inhibitors
AR063706A1 (es) 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
CL2008002793A1 (es) 2007-09-20 2009-09-04 Cgi Pharmaceuticals Inc Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras
JP5563472B2 (ja) 2007-11-28 2014-07-30 アイ アール エックス セーラピューティクス， インコーポレイテッド 免疫学的効果を増大させる方法
WO2009077334A1 (en) 2007-12-14 2009-06-25 F. Hoffmann-La Roche Ag Novel imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives
AU2009215191A1 (en) 2008-02-13 2009-08-20 Gilead Connecticut, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
US20110002989A1 (en) 2008-03-07 2011-01-06 Pfizer Inc. Methods, dosage forms and kits for administering ziprasidone without food
CA2728016C (en) 2008-06-24 2017-02-28 F. Hoffmann-La Roche Ag Novel substituted pyridin-2-ones and pyridazin-3-ones
JP5490789B2 (ja) 2008-07-02 2014-05-14 エフ．ホフマン−ラ ロシュ アーゲー キナーゼ阻害剤としての新規なフェニルピラジノン
ES2552681T3 (es) 2008-07-15 2015-12-01 F. Hoffmann-La Roche Ag Nuevas fenil-imidazopiridinas y piridazinas
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
PE20120058A1 (es) * 2008-12-08 2012-02-02 Gilead Connecticut Inc Derivados de imidazopirazina como inhibidores de syk
SG10201707798SA (en) 2008-12-08 2017-10-30 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
US8362013B2 (en) 2009-04-30 2013-01-29 Abbvie Inc. Salt of ABT-263 and solid-state forms thereof
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
ES2453477T3 (es) 2009-12-18 2014-04-07 Frieslandcampina Nederland Holding B.V. Composición de excipiente coprocesada para un comprimido, su preparación y uso
WO2011112995A1 (en) 2010-03-11 2011-09-15 Gilead Sciences, Inc. Imidazopyridines syk inhibitors
CN107266435A (zh) 2010-11-23 2017-10-20 Abbvie 公司 细胞凋亡诱导剂的盐和晶形
JPWO2012147832A1 (ja) * 2011-04-27 2014-07-28 第一三共株式会社 フェニルピロール誘導体の結晶
WO2013188856A1 (en) 2012-06-14 2013-12-19 Gilead Connecticut, Inc. Imidazopyrazine syk inhibitors
US20140051696A1 (en) 2012-08-14 2014-02-20 Gilead Calistoga Llc Therapies for treating cancer
US20140148430A1 (en) 2012-11-26 2014-05-29 Gilead Connecticut, Inc. Imidazopyridines syk inhibitors
TW201602108A (zh) 2013-07-30 2016-01-16 吉李德康乃狄克公司 脾酪胺酸激酶（Ｓｙｋ）抑制劑之多晶型
MD4684B1 (ro) 2013-07-30 2020-03-31 Gilead Connecticut INc. Formulări pe bază de imidazopirazine în calitate de inhibitori SYK
WO2015017610A1 (en) 2013-07-31 2015-02-05 Gilead Sciences, Inc. Syk inhibitors
ES2835549T3 (es) 2013-12-04 2021-06-22 Kronos Bio Inc Métodos de tratamiento de cánceres
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
CN116813596A (zh) 2013-12-23 2023-09-29 吉利德科学公司 大环hcv ns3抑制三肽的合成
TW201617074A (zh) 2014-07-14 2016-05-16 吉李德科學股份有限公司 Ｓｙｋ（脾酪胺酸激酶）抑制劑
CA2955180A1 (en) 2014-07-14 2016-01-21 Gilead Sciences, Inc. Combinations comprising entospletinib and a vinca-alkaloid for treating cancers
TW201639573A (zh) 2015-02-03 2016-11-16 吉李德科學股份有限公司 有關治療癌症之合併治療
JP2018513173A (ja) 2015-04-21 2018-05-24 ギリアード サイエンシーズ， インコーポレイテッド Ｓｙｋ阻害剤を用いた慢性移植片対宿主病の処置

Also Published As

Publication number Publication date
TW201602108A (zh) 2016-01-16
SV2016005149A (es) 2017-04-03
UY35683A (es) 2015-02-27
KR101810798B1 (ko) 2017-12-19
EA201791873A1 (ru) 2018-09-28
JP2016527268A (ja) 2016-09-08
HUE052090T2 (hu) 2021-04-28
MY176803A (en) 2020-08-21
AU2014296308C1 (en) 2018-09-13
PE20160862A1 (es) 2016-09-24
EP3027618B1 (en) 2020-07-08
CN105452252A (zh) 2016-03-30
US20160168155A1 (en) 2016-06-16
CA2919661C (en) 2020-08-18
HK1222390A1 (zh) 2017-06-30
ES2822285T3 (es) 2021-04-30
US20150038505A1 (en) 2015-02-05
US9657023B2 (en) 2017-05-23
CR20160098A (es) 2016-07-11
MD4659B1 (ro) 2019-11-30
EA201690172A1 (ru) 2016-07-29
AU2017225136A1 (en) 2017-10-05
MD20160017A2 (ro) 2016-08-31
HRP20201582T1 (hr) 2021-02-19
WO2015017460A1 (en) 2015-02-05
IL243579A0 (en) 2016-02-29
KR20160038007A (ko) 2016-04-06
US20170217967A1 (en) 2017-08-03
US20180099971A1 (en) 2018-04-12
MX2016001304A (es) 2016-04-07
EA029281B1 (ru) 2018-03-30
AR097158A1 (es) 2016-02-24
EP3027618A1 (en) 2016-06-08
SG11201600385TA (en) 2016-02-26
CL2016000238A1 (es) 2016-07-22
CA2919661A1 (en) 2015-02-05
AU2014296308B2 (en) 2017-06-08
JP6230709B2 (ja) 2017-11-15
SI3027618T1 (sl) 2021-01-29
PL3027618T3 (pl) 2021-04-19
PH12016500169A1 (en) 2016-04-25
NZ715776A (en) 2017-04-28
AU2014296308A1 (en) 2016-02-04
AP2016009008A0 (en) 2016-01-31
PT3027618T (pt) 2020-10-12
US10266539B2 (en) 2019-04-23

Similar Documents

Publication Publication Date Title
DK3027618T3 (da) Polymorf af syk-hæmmere
DK3080100T3 (da) Hæmmere af lysinspecifik demethylase-1
DK3102576T3 (da) Dihydropyrrolopyridininhibitorer af ror-gamma
DK2968208T3 (da) Behandling af kataplexi
DK3068776T3 (da) Inhibitorer af replikation af influenzavira
AR095266A1 (es) Inhibidores de bromodominios tetraciclicos
DK2961388T3 (da) Kombinationer af lægemidler
DK3395814T3 (da) Hæmmere af fibroblastvækstfaktorreceptoren
DK3030323T3 (da) Kdm1a-inhibitorer til behandlingen af sygdom
DK3119772T3 (da) Heteroaryl syk-hæmmere
DK3057586T3 (da) Bromodomæneinhibitorer
DK3087183T3 (da) Modulation af angiopoietin-3-lignende ekspression
DK3160956T3 (da) Inhibitorer af lysin-specifik demethylase-1
DK3164380T3 (da) Hæmmere af lysinspecifik demethylase-1
DK2845905T3 (da) Fremstilling af oligosaccharider
DK2970954T3 (da) Modifikation af polypeptider
DK2981255T3 (da) Terapeutiske anvendelser af empagliflozin
DK3008039T3 (da) Krystallinsk form af en mdm2-inhibitor
DK2961766T3 (da) Kvantificering af vaccinesammensætninger
DK3021838T3 (da) Behandling af fedme
DK3068854T4 (da) Fjernelse af uønskede propanolbestanddele
DK3068359T3 (da) Indikator for hældningen af sengen
DK3626270T3 (da) Behandling af kardiovaskulære sygdomme
DK3106150T3 (da) Forbedrede farmaceutiske sammensætninger af pimobendan
DK2833884T3 (da) Anvendelse af ccr3-inhibitorer