JP2013516489A5 - - Google Patents
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- JP2013516489A5 JP2013516489A5 JP2012548193A JP2012548193A JP2013516489A5 JP 2013516489 A5 JP2013516489 A5 JP 2013516489A5 JP 2012548193 A JP2012548193 A JP 2012548193A JP 2012548193 A JP2012548193 A JP 2012548193A JP 2013516489 A5 JP2013516489 A5 JP 2013516489A5
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- Prior art keywords
- pharmaceutical composition
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- modified oligonucleotide
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 108091034117 Oligonucleotide Proteins 0.000 claims 13
- 239000002777 nucleoside Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 241001465754 Metazoa Species 0.000 claims 6
- 125000003835 nucleoside group Chemical group 0.000 claims 6
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 5
- 102100025668 Angiopoietin-related protein 3 Human genes 0.000 claims 4
- 101000693085 Homo sapiens Angiopoietin-related protein 3 Proteins 0.000 claims 4
- 230000002503 metabolic effect Effects 0.000 claims 3
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 208000016097 disease of metabolism Diseases 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29360410P | 2010-01-08 | 2010-01-08 | |
| US61/293,604 | 2010-01-08 | ||
| PCT/US2011/020606 WO2011085271A2 (en) | 2010-01-08 | 2011-01-07 | Modulation of angiopoietin-like 3 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015156939A Division JP6440592B2 (ja) | 2010-01-08 | 2015-08-07 | アンジオポエチン様３発現の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516489A JP2013516489A (ja) | 2013-05-13 |
| JP2013516489A5 true JP2013516489A5 (enExample) | 2013-08-08 |
| JP5822845B2 JP5822845B2 (ja) | 2015-11-25 |
Family
ID=44306180
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548193A Expired - Fee Related JP5822845B2 (ja) | 2010-01-08 | 2011-01-07 | アンジオポエチン様３発現の調節 |
| JP2015156939A Expired - Fee Related JP6440592B2 (ja) | 2010-01-08 | 2015-08-07 | アンジオポエチン様３発現の調節 |
| JP2017098842A Pending JP2017165765A (ja) | 2010-01-08 | 2017-05-18 | アンジオポエチン様３発現の調節 |
| JP2020032712A Pending JP2020100654A (ja) | 2010-01-08 | 2020-02-28 | アンジオポエチン様３発現の調節 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015156939A Expired - Fee Related JP6440592B2 (ja) | 2010-01-08 | 2015-08-07 | アンジオポエチン様３発現の調節 |
| JP2017098842A Pending JP2017165765A (ja) | 2010-01-08 | 2017-05-18 | アンジオポエチン様３発現の調節 |
| JP2020032712A Pending JP2020100654A (ja) | 2010-01-08 | 2020-02-28 | アンジオポエチン様３発現の調節 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US8653047B2 (enExample) |
| EP (2) | EP2521556B1 (enExample) |
| JP (4) | JP5822845B2 (enExample) |
| CN (3) | CN111700901A (enExample) |
| AU (1) | AU2011203986C1 (enExample) |
| CA (1) | CA2786071C (enExample) |
| DK (1) | DK2521556T3 (enExample) |
| ES (1) | ES2677969T3 (enExample) |
| WO (1) | WO2011085271A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010064146A2 (en) | 2008-12-02 | 2010-06-10 | Chiralgen, Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| CA2786071C (en) | 2010-01-08 | 2021-01-12 | Isis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| CN107287202B (zh) | 2011-06-21 | 2021-03-16 | 阿尔尼拉姆医药品有限公司 | 血管生成素样3(ANGPTL3)iRNA组合物及其使用方法 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| US10023861B2 (en) | 2011-08-29 | 2018-07-17 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| HRP20191883T1 (hr) * | 2011-11-07 | 2019-12-27 | Ionis Pharmaceuticals, Inc. | Modulacija ekspresije tmprss6 |
| ES2923787T5 (en) * | 2011-11-18 | 2025-12-01 | Alnylam Pharmaceuticals Inc | Modified rnai agents |
| CA2879066C (en) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | キラル制御 |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| WO2014076196A1 (en) | 2012-11-15 | 2014-05-22 | Santaris Pharma A/S | Anti apob antisense conjugate compounds |
| CA2893801A1 (en) | 2013-01-30 | 2014-08-07 | F. Hoffmann-La Roche Ag | Lna oligonucleotide carbohydrate conjugates |
| RU2670614C9 (ru) | 2013-05-01 | 2018-11-23 | Ионис Фармасьютикалз, Инк. | Композиции и способы модулирования экспрессии hbv и ttr |
| TWI657819B (zh) | 2013-07-19 | 2019-05-01 | 美商Ionis製藥公司 | 用於調節τ蛋白表現之組合物 |
| NZ720286A (en) | 2013-12-24 | 2022-12-23 | Ionis Pharmaceuticals Inc | Modulation of angiopoietin-like 3 expression |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| KR20230152178A (ko) | 2014-01-16 | 2023-11-02 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| US9382540B2 (en) * | 2014-05-01 | 2016-07-05 | Isis Pharmaceuticals, Inc | Compositions and methods for modulating angiopoietin-like 3 expression |
| WO2015179693A1 (en) | 2014-05-22 | 2015-11-26 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| US20180245077A1 (en) * | 2015-03-20 | 2018-08-30 | Protiva Biotherapeutics, Inc. | Compositions and methods for treating hypertriglyceridemia |
| RU2017137410A (ru) | 2015-04-03 | 2019-05-06 | Ионис Фармасьютикалз, Инк. | Соединения и способы модулирования экспрессии tmprss6 |
| EA201792263A1 (ru) | 2015-04-13 | 2018-08-31 | Элнилэм Фармасьютикалз, Инк. | КОМПОЗИЦИИ НА ОСНОВЕ iRNA ПРОТИВ АНГИОПОЭТИН-ПОДОБНОГО БЕЛКА 3 (ANGPTL3) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| ES2989704T3 (es) | 2015-11-06 | 2024-11-27 | Ionis Pharmaceuticals Inc | Compuestos antisentido conjugados para uso terapéutico |
| CN113952353A (zh) | 2015-11-06 | 2022-01-21 | Ionis制药公司 | 调节载脂蛋白(a)表达 |
| KR20180073665A (ko) * | 2015-11-06 | 2018-07-02 | 젬파이어 세러퓨틱스 인코포레이티드 | 심혈관 질환의 치료를 위한 젬카빈 조합 |
| MA44234B1 (fr) * | 2016-02-17 | 2023-10-31 | Regeneron Pharma | Procédés de traitement ou de prévention de l'athérosclérose par administration d'un inhibiteur d'angptl3 |
| EA201891979A1 (ru) | 2016-03-03 | 2019-01-31 | Ридженерон Фармасьютикалз, Инк. | Способы лечения пациентов с гиперлипидемией введением ингибитора pcsk9 в комбинации с ингибитором angptl3 |
| AU2017234678A1 (en) * | 2016-03-16 | 2018-08-16 | Ionis Pharmaceuticals, Inc. | Methods of modulating KEAP1 |
| IL262591B (en) * | 2016-04-28 | 2022-07-01 | Regeneron Pharma | Treatment methods for patients with hereditary high blood cholesterol |
| SG10201913477UA (en) | 2016-04-29 | 2020-02-27 | Univ Nanyang Tech | G-quadruplex-containing antisense oligonucleotides |
| JP7074345B2 (ja) | 2016-06-22 | 2022-05-24 | プロキューアール セラピューティクス ツー ベスローテン フェンノートシャップ | 一本鎖ｒｎａ編集オリゴヌクレオチド |
| CA3035293A1 (en) * | 2016-09-01 | 2018-03-08 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| JP2019535839A (ja) | 2016-11-29 | 2019-12-12 | ピュアテック ヘルス エルエルシー | 治療剤の送達のためのエクソソーム |
| CN113652431A (zh) * | 2016-12-21 | 2021-11-16 | 苏州瑞博生物技术股份有限公司 | 一种小干扰核酸和药物组合物及其用途 |
| US11274300B2 (en) | 2017-01-19 | 2022-03-15 | Proqr Therapeutics Ii B.V. | Oligonucleotide complexes for use in RNA editing |
| EP3678273A4 (en) | 2017-08-30 | 2021-01-06 | Kyocera Corporation | POWER SUPPLY MANAGEMENT PROCESS AND POWER SUPPLY MANAGEMENT DEVICE |
| EP3681513A4 (en) | 2017-09-14 | 2021-09-22 | Arrowhead Pharmaceuticals, Inc. | RNAI AGENTS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF ANGIOPOIETIN-LIKE 3 (ANGPTL3) AND METHOD OF USE |
| WO2019105419A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| KR102756073B1 (ko) | 2017-12-01 | 2025-01-20 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 이중-가닥 올리고뉴클레오티드, 조성물 및 이중-가닥 올리고뉴클레오티드를 포함하는 접합체, 그의 제조 방법 및 그의 용도 |
| US12083142B2 (en) | 2017-12-01 | 2024-09-10 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| JP7261494B2 (ja) | 2017-12-01 | 2023-04-20 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| WO2019105435A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| HRP20250408T1 (hr) | 2017-12-29 | 2025-06-06 | Suzhou Ribo Life Science Co., Ltd. | Kojugati i njihova priprema i uporaba |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| US11918600B2 (en) | 2018-08-21 | 2024-03-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof |
| CN111655297A (zh) | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| CA3117750A1 (en) | 2018-11-13 | 2020-05-22 | Lipigon Pharmaceuticals Ab | Angptl4 oligonucleotides influencing the regulation of the fatty acid metabolism |
| CN112423795A (zh) * | 2018-12-28 | 2021-02-26 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2020146477A1 (en) * | 2019-01-08 | 2020-07-16 | Avogadro Development Corp. | Treatment of fatty liver disease |
| CN111973617A (zh) * | 2019-05-23 | 2020-11-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| EP4331608A1 (en) * | 2020-09-30 | 2024-03-06 | Nanopeptide (Qingdao) Biotechnology Ltd. | Target ligand |
| MX2023010249A (es) | 2021-03-04 | 2023-09-15 | Alnylam Pharmaceuticals Inc | Composiciones de arni de proteina similar a la angiopoyetina 3 (angptl3) y metodos para usarlas. |
| BR112023026971A2 (pt) * | 2021-06-21 | 2024-03-12 | Shanghai Junshi Biosciences Co Ltd | Sirna para inibir expressão do gene angptl3 e usos do mesmo |
| EP4453210A1 (en) | 2021-12-22 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Treatment of kidney diseases with angiopoietin like 3 (angptl3) inhibitors |
| WO2023134705A1 (zh) * | 2022-01-11 | 2023-07-20 | 上海金中锘美生物医药科技有限公司 | 抑制angptl3表达的rna干扰剂及其用途 |
| WO2024032608A1 (zh) * | 2022-08-08 | 2024-02-15 | 大睿生物医药科技(上海)有限公司 | 调控ANGPTL3基因活性的siRNA分子 |
| CN120265775A (zh) | 2022-11-10 | 2025-07-04 | 瑞泽恩制药公司 | 用血管生成素样3(angptl3)抑制剂和溶质载体家族5成员2(slc5a2)抑制剂的组合治疗肾脏疾病 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2699808A (en) | 1944-10-06 | 1955-01-18 | Mark W Lowe | Apparatus for peeling tomatoes |
| US2699508A (en) | 1951-12-21 | 1955-01-11 | Selectronics Inc | Method of mounting and construction of mounting for low frequency piezoelectric crystals |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| JPH08504559A (ja) | 1992-12-14 | 1996-05-14 | ハネウエル・インコーポレーテッド | 個別に制御される冗長巻線を有するモータシステム |
| US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5656408A (en) | 1996-04-29 | 1997-08-12 | Xerox Corporation | Coated carrier particles |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| ATE293123T1 (de) | 1997-09-12 | 2005-04-15 | Exiqon As | Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| DE69935799T2 (de) * | 1998-09-15 | 2007-12-27 | Btg International Ltd. | Therapeutische zusammenstellungen |
| CA2372085C (en) | 1999-05-04 | 2009-10-27 | Exiqon A/S | L-ribo-lna analogues |
| US6525191B1 (en) | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| WO2001005825A2 (en) * | 1999-07-16 | 2001-01-25 | Hyseq, Inc. | Nucleic acid sequences encoding putative angiopoietin proteins |
| CN1433482A (zh) | 1999-12-09 | 2003-07-30 | 三共株式会社 | 高脂血症的治疗或预防剂的检验方法 |
| IL159153A0 (en) | 2001-06-08 | 2004-06-01 | Sankyo Co | Methods for testing drugs for treating or preventing diseases such as hyperlipidemia |
| CA2452458A1 (en) * | 2001-07-03 | 2003-01-16 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| CN101905024A (zh) | 2001-11-16 | 2010-12-08 | 杰南技术公司 | 含有血管生成素-样蛋白质3angptl3的组合物及其使用方法 |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| US8604183B2 (en) | 2002-11-05 | 2013-12-10 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2′-modified nucleosides for use in gene modulation |
| US7511131B2 (en) * | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| EP2213738B1 (en) | 2002-11-14 | 2012-10-10 | Dharmacon, Inc. | siRNA molecules targeting Bcl-2 |
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| WO2004072046A2 (en) | 2003-02-12 | 2004-08-26 | Carex S.A. | Quinoline derivatives and their use for modulation of lxr activity |
| WO2004106356A1 (en) | 2003-05-27 | 2004-12-09 | Syddansk Universitet | Functionalized nucleotide derivatives |
| JPWO2005021745A1 (ja) | 2003-08-22 | 2006-10-26 | 学校法人日本大学 | 肝細胞癌に関連する遺伝子 |
| JP4731324B2 (ja) | 2003-08-28 | 2011-07-20 | 武 今西 | Ｎ−ｏ結合性架橋構造型新規人工核酸 |
| WO2005027962A1 (en) | 2003-09-18 | 2005-03-31 | Isis Pharmaceuticals, Inc. | 4’-thionucleosides and oligomeric compounds |
| US7468431B2 (en) * | 2004-01-22 | 2008-12-23 | Isis Pharmaceuticals, Inc. | Modulation of eIF4E-BP2 expression |
| TW200539867A (en) * | 2004-04-13 | 2005-12-16 | Arena Pharm Inc | Human g protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders |
| KR20070085113A (ko) | 2004-05-11 | 2007-08-27 | 가부시키가이샤 알파젠 | Rna간섭을 생기게 하는 폴리뉴클레오티드, 및 이를 이용한유전자발현억제 방법 |
| WO2006014678A2 (en) * | 2004-07-20 | 2006-02-09 | Genentech, Inc. | Compositions and methods of using angiopoietin-like 4 protein |
| CN101044164A (zh) | 2004-07-20 | 2007-09-26 | 健泰科生物技术公司 | 血管生成素样4蛋白抑制剂，组合，以及其用途 |
| WO2006034348A2 (en) | 2004-09-17 | 2006-03-30 | Isis Pharmaceuticals, Inc. | Enhanced antisense oligonucleotides |
| US20060147894A1 (en) | 2004-12-30 | 2006-07-06 | Vicam, L.P. | Jacketed vessel for holding semen for sex biasing mammals through artificial insemination and systems and methods for enhancing the probability of sex biasing using the same |
| EP1984381B1 (en) | 2006-01-27 | 2010-09-29 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
| EP2023940B1 (en) | 2006-05-05 | 2011-06-22 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of sglt2 |
| DK2066684T3 (da) | 2006-05-11 | 2012-10-22 | Isis Pharmaceuticals Inc | 5´-Modificerede bicycliske nukleinsyreanaloge |
| WO2008017081A1 (en) * | 2006-08-04 | 2008-02-07 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of jnk proteins |
| US8093222B2 (en) * | 2006-11-27 | 2012-01-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| CN101589143A (zh) * | 2006-11-27 | 2009-11-25 | Isis药物公司 | 用于治疗高胆固醇血症的方法 |
| EA019661B1 (ru) * | 2006-12-08 | 2014-05-30 | Лексикон Фармасьютикалз, Инк. | Моноклональные антитела против angptl3 |
| EP2125852B1 (en) | 2007-02-15 | 2016-04-06 | Ionis Pharmaceuticals, Inc. | 5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom |
| CN102007212B (zh) | 2008-03-07 | 2013-11-20 | 国立大学法人富山大学 | 同源重组方法和克隆方法以及试剂盒 |
| JP5207355B2 (ja) | 2008-03-12 | 2013-06-12 | 凸版印刷株式会社 | 標的ヌクレオチド配列を有する核酸の検出方法、プローブセット、及び核酸の識別方法 |
| WO2009148605A2 (en) | 2008-06-04 | 2009-12-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| AT507215B1 (de) | 2009-01-14 | 2010-03-15 | Boehler Edelstahl Gmbh & Co Kg | Verschleissbeständiger werkstoff |
| CA2786071C (en) | 2010-01-08 | 2021-01-12 | Isis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| US9984408B1 (en) | 2012-05-30 | 2018-05-29 | Amazon Technologies, Inc. | Method, medium, and system for live video cooperative shopping |
| EP2733390B1 (en) | 2012-11-15 | 2020-05-13 | Volvo Car Corporation | Dampening structure for gear shift cables |
| US10120707B2 (en) | 2015-12-08 | 2018-11-06 | Paypal, Inc. | Deployment of development environments |
| US9778708B1 (en) | 2016-07-18 | 2017-10-03 | Lenovo Enterprise Solutions (Singapore) Pte. Ltd. | Dual sided latching retainer for computer modules |
-
2011
- 2011-01-07 CA CA2786071A patent/CA2786071C/en active Active
- 2011-01-07 US US13/520,997 patent/US8653047B2/en active Active
- 2011-01-07 JP JP2012548193A patent/JP5822845B2/ja not_active Expired - Fee Related
- 2011-01-07 ES ES11732249.5T patent/ES2677969T3/es active Active
- 2011-01-07 CN CN202010636959.XA patent/CN111700901A/zh active Pending
- 2011-01-07 EP EP11732249.5A patent/EP2521556B1/en active Active
- 2011-01-07 AU AU2011203986A patent/AU2011203986C1/en not_active Ceased
- 2011-01-07 CN CN201610643333.5A patent/CN106146591B/zh not_active Expired - Fee Related
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- 2011-01-07 DK DK11732249.5T patent/DK2521556T3/en active
- 2011-01-07 EP EP18174926.8A patent/EP3421040A1/en not_active Withdrawn
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2018
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